253 results on '"Monteagudo, Edith"'
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2. Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease
3. Determination of acetyl coenzyme A in human whole blood by ultra-performance liquid chromatography-mass spectrometry
4. Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington’s Disease
5. The Urine Metabolome of R6/2 and zQ175DN Huntington’s Disease Mouse Models
6. Conformational dynamics and DNA recognition by human MutSbeta
7. An efficient liquid chromatography-high resolution mass spectrometry approach for the optimization of the metabolic stability of therapeutic peptides
8. Design and evaluation of [¹⁸F]CHDI-650 as a positron emission tomography ligand to image mutant Huntingtin aggregates
9. Fatty acid acylated peptide therapeutics: discovery of omega-n oxidation of the lipid chain as a novel metabolic pathway in preclinical species
10. Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates
11. Discovery and antiviral profile of new sulfamoylbenzamide derivatives as HBV capsid assembly modulators
12. Identification and in vitro characterization of a new series of potent and highly selective G9a inhibitors as novel anti-fibroadipogenic agents
13. PEGylation of Neuromedin U yields a promising candidate for the treatment of obesity and diabetes
14. Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase
15. Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models
16. ApoA-I mimetic peptides promote pre-β HDL formation in vivo causing remodeling of HDL and triglyceride accumulation at higher dose
17. Oligomerization, albumin binding and catabolism of therapeutic peptides in the subcutaneous compartment: An investigation on lipidated GLP-1 analogs
18. A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma
19. Kynurenine Pathway Activation and Deviation in Fibrosing Chronic Graft-Versus-Host Disease
20. High-Throughput Microsomal Stability Assay for Screening New Chemical Entities in Drug Discovery
21. [11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins
22. Personalized Metabolic Profile by Synergic Use of NMR and HRMS
23. Turnover rate of coenzyme A in mouse brain and liver
24. Conformations of laulimalide in DMSO-d6
25. Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin-2 for Cardiovascular Diseases
26. Cyclic Phosphopantothenic Acid Prodrugs for Treatment of Pantothenate Kinase-Associated Neurodegeneration
27. Preclinical assessment of capsid assembly modulators (CAMs) of varying potency revealed a novel class of picomolar-acting CAMs inducing neither significant HBcAg cytoplasmic retention nor adverse interactions with HBcAg-specific adaptive immunity
28. Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand
29. Comparison of different protein precipitation and solid‐phase extraction protocols for the study of the catabolism of peptide drugs by LC‐HRMS
30. Establishment of an in Vitro Human Blood-Brain Barrier Model Derived from Induced Pluripotent Stem Cells and Comparison to a Porcine Cell-Based System
31. 5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein
32. Turbulent Flow Chromatography TFC-tandem mass spectrometry supporting in vitro/vivo studies of NCEs in high throughput fashion
33. A novel strategy for reducing phospholipids-based matrix effect in LC–ESI-MS bioanalysis by means of HybridSPE
34. Synthesis and Biological Evaluation of RGD–Cryptophycin Conjugates for Targeted Drug Delivery
35. Synthesis of enantiomerically pure 1-alkylimidazoles
36. NMR-Spectroscopic, computational and mass-spectrometric investigations on the cis/ trans analogues of 2,3,4-trihydronaphthalene-1-one
37. A novel method using nuclear magnetic resonance for plasma protein binding assessment in drug discovery programs
38. Application of an in Vitro Blood–Brain Barrier Model in the Selection of Experimental Drug Candidates for the Treatment of Huntington’s Disease
39. Doxorubicin disaccharide analogue: apoptosis-related improvement of efficacy in vivo
40. 2′- C-Methyluridine phosphoramidite: a new building block for the preparation of RNA analogues carrying the 2′-hydroxyl group
41. Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides
42. A liquid chromatography high-resolution mass spectrometry in vitro assay to assess metabolism at the injection site of subcutaneously administered therapeutic peptides
43. Fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy for pantothenate kinase-associated neurodegeneration: Mechanism of action and efficacy in nonclinical models
44. Configurational requirements of the sugar moiety for the pharmacological activity of anthracycline disaccharides
45. AS001 - Preclinical assessment of capsid assembly modulators (CAMs) of varying potency revealed a novel class of picomolar-acting CAMs inducing neither significant HBcAg cytoplasmic retention nor adverse interactions with HBcAg-specific adaptive immunity
46. Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides.
47. Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive Systems
48. Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs
49. Use of ‘dilute-and-shoot’ liquid chromatography-high resolution mass spectrometry in preclinical research: application to a DMPK study of perhexiline in mouse plasma
50. N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists
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