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1. State of the Art in Sub-Phenotyping Midbrain Dopamine Neurons

Author: Valentina Basso, Máté D. Döbrössy, Lachlan H. Thompson, Deniz Kirik, Heidi R. Fuller, and Monte A. Gates
Subjects: substantia nigra pars compacta (SNpc), ventral tegmental area (VTA), dopamine (DA), midbrain dopaminergic neurons (mDA), Parkinson’s disease (PD), schizophrenia (SZ), Biology (General), QH301-705.5
Abstract: Dopaminergic neurons in the ventral tegmental area (VTA) and the substantia nigra pars compacta (SNpc) comprise around 75% of all dopaminergic neurons in the human brain. While both groups of dopaminergic neurons are in close proximity in the midbrain and partially overlap, development, function, and impairments in these two classes of neurons are highly diverse. The molecular and cellular mechanisms underlying these differences are not yet fully understood, but research over the past decade has highlighted the need to differentiate between these two classes of dopaminergic neurons during their development and in the mature brain. This differentiation is crucial not only for understanding fundamental circuitry formation in the brain but also for developing therapies targeted to specific dopaminergic neuron classes without affecting others. In this review, we summarize the state of the art in our understanding of the differences between the dopaminergic neurons of the VTA and the SNpc, such as anatomy, structure, morphology, output and input, electrophysiology, development, and disorders, and discuss the current technologies and methods available for studying these two classes of dopaminergic neurons, highlighting their advantages, limitations, and the necessary improvements required to achieve more-precise therapeutic interventions.
Published: 2024
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2. The Wide Field Monitor (WFM) of the China-Europe eXTP (enhanced X-ray Timing and Polarimetry) mission

Author: Hernanz, Margarita, Feroci, Marco, Evangelista, Yuri, Meuris, Aline, Schanne, Stéphane, Zampa, Gianluigi, Tenzer, Chris, Bayer, Jörg, Nowosielski, Witold, Michalska, Malgorzata, Kalemci, Emrah, Sungur, Müberra, Brandt, Søren, Kuvvetli, Irfan, Franco, Daniel Alvarez, Carmona, Alex, Gálvez, José-Luis, Patruno, Alessandro, Zand, Jean in' t, Zwart, Frans, Santangelo, Andrea, Bozzo, Enrico, Zhang, Shuang-Nan, Lu, Fangjun, Xu, Yupeng, Campana, Riccardo, Del Monte, Ettore, Ceraudo, Francesco, Nuti, Alessio, Della Casa, Giovanni, Argan, Andrea, Minervini, Gabriele, Antonelli, Matias, Bonvicini, Valter, Boezio, Mirko, Cirrincione, Daniela, Munini, Riccardo, Rachevski, Alexandre, Vacchi, Andrea, Zampa, Nicola, Rashevskaya, Irina, Ficorella, Francesco, Picciotto, Antonino, Zorzi, Nicola, Baudin, David, Bouyjou, Florent, Gevin, Olivier, Limousin, Olivier, Hedderman, Paul, Pliego, Samuel, Xiong, Hao, de la Rie, Rob, Laubert, Phillip, Aitink-Kroes, Gabby, Kuiper, Lucien, Orleanski, Piotr, Skup, Konrad, Tcherniak, Denis, Turhan, Onur, Bozkurt, Ayhan, and Onat, Ahmet
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract: The eXTP mission is a major project of the Chinese Academy of Sciences (CAS), with a large involvement of Europe. Its scientific payload includes four instruments: SFA, PFA, LAD and WFM. They offer an unprecedented simultaneous wide-band Xray timing and polarimetry sensitivity. A large European consortium is contributing to the eXTP study, both for the science and the instrumentation. Europe is expected to provide two of the four instruments: LAD and WFM; the LAD is led by Italy and the WFM by Spain. The WFM for eXTP is based on the design originally proposed for the LOFT ESA M3 mission, that underwent a Phase A feasibility study. It will be a wide field of view X-ray monitor instrument working in the 2-50 keV energy range, achieved with large-area Silicon Drift Detectors (SDDs), similar to the ones used for the LAD but with better spatial resolution. The WFM will consist of 3 pairs of coded mask cameras with a total combined field of view (FoV) of 90x180 degrees at zero response and a source localisation accuracy of ~1 arc min. The main goal of the WFM is to provide triggers for the target of opportunity observations of the SFA, PFA and LAD, in order to perform the core science programme, dedicated to the study of matter under extreme conditions of density, gravity and magnetism. In addition, the unprecedented combination of large field of view and imaging capability, down to 2 keV, of the WFM will allow eXTP to make important discoveries of the variable and transient X-ray sky, and provide X-ray coverage of a broad range of astrophysical objects covered under 'observatory science', such as gamma-ray bursts, fast radio bursts, gravitational wave electromagnetic counterparts. In this paper we provide an overview of the WFM instrument, explaining its design, configuration, and anticipated performance., Comment: 15 pages, 13 figures, Proceedings of SPIE 13093, Space Telescopes and Instrumentation 2024: Ultraviolet to Gamma Ray; Proceedings Volume 13093, Space Telescopes and Instrumentation 2024: Ultraviolet to Gamma Ray; 130931Y (2024); doi: 10.1117/12.3020020
Published: 2024
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3. Evidence for a shock-compressed magnetic field in the northwestern rim of Vela Jr. from X-ray polarimetry

Author: Prokhorov, Dmitry A., Yang, Yi-Jung, Ferrazzoli, Riccardo, Vink, Jacco, Slane, Patrick, Costa, Enrico, Silvestri, Stefano, Zhou, Ping, Bucciantini, Niccolò, Di Marco, Alessandro, Weisskopf, Martin C., Baldini, Luca, Doroshenko, Victor, Ehlert, Steven R., Heyl, Jeremy, Kaaret, Philip, Kim, Dawoon E., Marin, Frédéric, Mizuno, Tsunefumi, Ng, Chi-Yung, Pesce-Rollins, Melissa, Sgrò, Carmelo, Soffitta, Paolo, Swartz, Douglas A., Tamagawa, Toru, Xie, Fei, Agudo, Iván, Antonelli, Lucio A., Bachetti, Matteo, Baumgartner, Wayne H., Bellazzini, Ronaldo, Bianchi, Stefano, Bongiorno, Stephen D., Bonino, Raffaella, Brez, Alessandro, Capitanio, Fiamma, Castellano, Simone, Cavazzuti, Elisabetta, Chen, Chien-Ting, Ciprini, Stefano, De Rosa, Alessandra, Del Monte, Ettore, Di Gesu, Laura, Di Lalla, Niccolò, Donnarumma, Immacolata, Dovčiak, Michal, Enoto, Teruaki, Evangelista, Yuri, Fabiani, Sergio, García, Javier A., Gunji, Shuichi, Iwakiri, Wataru, Jorstad, Svetlana G., Karas, Vladimir, Kislat, Fabian, Kitaguchi, Takao, Kolodziejczak, Jeffery J., Krawczynski, Henric, La Monaca, Fabio, Latronico, Luca, Liodakis, Ioannis, Maldera, Simone, Manfreda, Alberto, Marinucci, Andrea, Marscher, Alan P., Marshall, Herman L., Massaro, Francesco, Matt, Giorgio, Mitsuishi, Ikuyuki, Muleri, Fabio, Negro, Michela, O'Dell, Stephen L., Omodei, Nicola, Oppedisano, Chiara, Papitto, Alessandro, Pavlov, George G., Peirson, Abel L., Perri, Matteo, Petrucci, Pierre-Olivier, Pilia, Maura, Possenti, Andrea, Poutanen, Juri, Puccetti, Simonetta, Ramsey, Brian D., Rankin, John, Ratheesh, Ajay, Roberts, Oliver J., Romani, Roger W., Spandre, Gloria, Tavecchio, Fabrizio, Taverna, Roberto, Tawara, Yuzuru, Tennant, Allyn F., Thomas, Nicholas E., Tombesi, Francesco, Trois, Alessio, Tsygankov, Sergey S., Turolla, Roberto, Wu, Kinwah, and Zane, Silvia
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Synchrotron X-ray emission has been detected from nearly a dozen young supernova remnants (SNRs). X-rays of synchrotron origin exhibit linear polarization in a regular, non-randomly oriented magnetic field. The significant polarized X-ray emission from four such SNRs has already been reported on the basis of observations with the Imaging X-ray Polarimetry Explorer (IXPE). The magnetic-field structure as derived from IXPE observations is radial for Cassiopeia A, Tycho's SNR, and SN 1006, and tangential for RX J1713.7-3946. The latter together with the recent detection of a tangential magnetic field in SNR 1E 0102.2-7219 by the Australia Telescope Compact Array in the radio band shows that tangential magnetic fields can also be present in young SNRs. Thus, the dichotomy in polarization between young and middle-aged SNRs (radial magnetic fields in young SNRs, but tangential magnetic fields in middle-aged SNRs), previously noticed in the radio band, deserves additional attention. The present analysis of IXPE observations determines, for the first time, a magnetic-field structure in the northwestern rim of Vela Jr, also known as RX J0852.0-4622, and provides a new example of a young SNR with a tangential magnetic field., Comment: Accepted for publication in Astronomy and Astrophysics
Published: 2024

4. A Two-Week $IXPE$ Monitoring Campaign on Mrk 421

Author: Maksym, W. Peter, Liodakis, Ioannis, Saade, M. Lynne, Kim, Dawoon E., Middei, Riccardo, Di Gesu, Laura, Kiehlmann, Sebastian, Matzeu, Gabriele, Agudo, Iván, Marscher, Alan P., Ehlert, Steven R., Jorstad, Svetlana G., Kaaret, Philip, Marshall, Herman L., Pacciani, Luigi, Perri, Matteo, Puccetti, Simonetta, Kouch, Pouya M., Lindfors, Elina, Aceituno, Francisco José, Bonnoli, Giacomo, Casanova, Víctor, Escudero, Juan, Agís-González, Beatriz, Husillos, César, Morcuende, Daniel, Otero-Santos, Jorge, Sota, Alfredo, Piirola, Vilppu, Imazawa, Ryo, Sasada, Mahito, Fukazawa, Yasushi, Kawabata, Koji S., Uemura, Makoto, Mizuno, Tsunefumi, Nakaoka, Tatsuya, Akitaya, Hiroshi, McCall, Callum, Jermak, Helen E., Steele, Iain A., Borman, George A., Grishina, Tatiana S., Hagen-Thorn, Vladimir A., Kopatskaya, Evgenia N., Larionova, Elena G., Morozova, Daria A., Savchenko, Sergey S., Shishkina, Ekaterina V., Troitskiy, Ivan S., Troitskaya, Yulia V., Vasilyev, Andrey A., Zhovtan, Alexey V., Myserlis, Ioannis, Gurwell, Mark, Keating, Garrett, Rao, Ramprasad, Pauley, Colt, Angelakis, Emmanouil, Kraus, Alexander, Berdyugin, Andrei V., Kagitani, Masato, Kravtsov, Vadim, Poutanen, Juri, Sakanoi, Takeshi, Kang, Sincheol, Lee, Sang-Sung, Kim, Sang-Hyun, Cheong, Whee Yeon, Jeong, Hyeon-Woo, Song, Chanwoo, Blinov, Dmitry, Shablovinskaya, Elena, Antonelli, Lucio Angelo, Bachetti, Matteo, Baldini, Luca, Baumgartner, Wayne H., Bellazzini, Ronaldo, Bianchi, Stefano, Bongiorno, Stephen D., Bonino, Raffaella, Brez, Alessandro, Bucciantini, Niccoló, Capitanio, Fiamma, Castellano, Simone, Cavazzuti, Elisabetta, Chen, Chien-Ting, Ciprini, Stefano, Costa, Enrico, De Rosa, Alessandra, Del Monte, Ettore, Di Lalla, Niccoló, Di Marco, Alessandro, Donnarumma, Immacolata, Doroshenko, Victor, Dovčiak, Michal, Enoto, Teruaki, Evangelista, Yuri, Fabiani, Sergio, Ferrazzoli, Riccardo, Garcia, Javier A., Gunji, Shuichi, Hayashida, Kiyoshi, Heyl, Jeremy, Iwakiri, Wataru, Karas, Vladimir, Kislat, Fabian, Kitaguchi, Takao, Kolodziejczak, Jeffery J., Krawczynski, Henric, La Monaca, Fabio, Latronico, Luca, Maldera, Simone, Manfreda, Alberto, Marin, Frédéric, Marinucci, Andrea, Massaro, Francesco, Matt, Giorgio, Mitsuishi, Ikuyuki, Muleri, Fabio, Negro, Michela, Ng, C. -Y., O'Dell, Stephen L., Omodei, Nicola, Oppedisano, Chiara, Papitto, Alessandro, Pavlov, George G., Peirson, Abel Lawrence, Pesce-Rollins, Melissa, Petrucci, Pierre-Olivier, Pilia, Maura, Possenti, Andrea, Ramsey, Brian D., Rankin, John, Ratheesh, Ajay, Roberts, Oliver J., Romani, Roger W., Sgró, Carmelo, Slane, Patrick, Soffitta, Paolo, Spandre, Gloria, Swartz, Douglas A., Tamagawa, Toru, Tavecchio, Fabrizio, Taverna, Roberto, Tawara, Yuzuru, Tennant, Allyn F., Thomas, Nicholas E., Tombesi, Francesco, Trois, Alessio, Tsygankov, Sergey S., Turolla, Roberto, Vink, Jacco, Weisskopf, Martin C., Wu, Kinwah, Xie, Fei, and Zane, Silvia
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: X-ray polarization is a unique new probe of the particle acceleration in astrophysical jets made possible through the Imaging X-ray Polarimetry Explorer. Here we report on the first dense X-ray polarization monitoring campaign on the blazar Mrk 421. Our observations were accompanied by an even denser radio and optical polarization campaign. We find significant short-timescale variability in both X-ray polarization degree and angle, including a $\sim90^\circ$ angle rotation about the jet axis. We attribute this to random variations of the magnetic field, consistent with the presence of turbulence but also unlikely to be explained by turbulence alone. At the same time, the degree of lower-energy polarization is significantly lower and shows no more than mild variability. Our campaign provides further evidence for a scenario in which energy-stratified shock-acceleration of relativistic electrons, combined with a turbulent magnetic field, is responsible for optical to X-ray synchrotron emission in blazar jets., Comment: 23 pages, including 8 pages of appendices. 12 figures, 3 tables. Submitted to ApJ
Published: 2024

5. Dark Matter Search Results from 4.2 Tonne-Years of Exposure of the LUX-ZEPLIN (LZ) Experiment

Author: Aalbers, J., Akerib, D. S., Musalhi, A. K. Al, Alder, F., Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Baker, A., Balashov, S., Bang, J., Bargemann, J. W., Barillier, E. E., Bauer, D., Beattie, K., Benson, T., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Bishop, E., Blockinger, G. M., Boxer, B., Brew, C. A. J., Brás, P., Burdin, S., Buuck, M., Carmona-Benitez, M. C., Carter, M., Chawla, A., Chen, H., Cherwinka, J. J., Chin, Y. T., Chott, N. I., Converse, M. V., Coronel, R., Cottle, A., Cox, G., Curran, D., Dahl, C. E., Darlington, I., Dave, S., David, A., Delgaudio, J., Dey, S., de Viveiros, L., Di Felice, L., Ding, C., Dobson, J. E. Y., Druszkiewicz, E., Dubey, S., Eriksen, S. R., Fan, A., Fayer, S., Fearon, N. M., Fieldhouse, N., Fiorucci, S., Flaecher, H., Fraser, E. D., Fruth, T. M. A., Gaitskell, R. J., Geffre, A., Genovesi, J., Ghag, C., Ghosh, A., Gibbons, R., Gokhale, S., Green, J., van der Grinten, M. G. D., Haiston, J. J., Hall, C. R., Hall, T. J., Han, S., Hartigan-O'Connor, E., Haselschwardt, S. J., Hernandez, M. A., Hertel, S. A., Heuermann, G., Homenides, G. J., Horn, M., Huang, D. Q., Hunt, D., Jacquet, E., James, R. S., Johnson, J., Kaboth, A. C., Kamaha, A. C., K., Meghna K., Khaitan, D., Khazov, A., Khurana, I., Kim, J., Kim, Y. D., Kingston, J., Kirk, R., Kodroff, D., Korley, L., Korolkova, E. V., Kraus, H., Kravitz, S., Kreczko, L., Kudryavtsev, V. A., Lawes, C., Leonard, D. S., Lesko, K. T., Levy, C., Lin, J., Lindote, A., Lippincott, W. H., Lopes, M. I., Lorenzon, W., Lu, C., Luitz, S., Majewski, P. A., Manalaysay, A., Mannino, R. L., Maupin, C., McCarthy, M. E., McDowell, G., McKinsey, D. N., McLaughlin, J., McLaughlin, J. B., McMonigle, R., Mizrachi, E., Monte, A., Monzani, M. E., Mendoza, J. D. Morales, Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naylor, A., Nelson, H. N., Neves, F., Nguyen, A., O'Brien, C. L., Olcina, I., Oliver-Mallory, K. C., Orpwood, J., Oyulmaz, K. Y, Palladino, K. J., Palmer, J., Pannifer, N. J., Parveen, N., Patton, S. J., Penning, B., Pereira, G., Perry, E., Pershing, T., Piepke, A., Qie, Y., Reichenbacher, J., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Ritchey, E., Riyat, H. S., Rosero, R., Rushton, T., Rynders, D., Santone, D., Sazzad, A. B. M. R., Schnee, R. W., Sehr, G., Shafer, B., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Siniscalco, J., Smith, R., Solovov, V. N., Sorensen, P., Soria, J., Stancu, I., Stevens, A., Stifter, K., Suerfu, B., Sumner, T. J., Szydagis, M., Tiedt, D. R., Timalsina, M., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Usón, A., Vacheret, A., Vaitkus, A. C., Valentino, O., Velan, V., Wang, A., Wang, J. J., Wang, Y., Watson, J. R., Weeldreyer, L., Whitis, T. J., Wild, K., Williams, M., Wisniewski, W. J., Wolf, L., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Xia, Q., Xu, J., Xu, Y., Yeh, M., Yeum, D., Zha, W., and Zweig, E. A.
Subjects: High Energy Physics - Experiment
Abstract: We report results of a search for nuclear recoils induced by weakly interacting massive particle (WIMP) dark matter using the LUX-ZEPLIN (LZ) two-phase xenon time projection chamber. This analysis uses a total exposure of $4.2\pm0.1$ tonne-years from 280 live days of LZ operation, of which $3.3\pm0.1$ tonne-years and 220 live days are new. A technique to actively tag background electronic recoils from $^{214}$Pb $\beta$ decays is featured for the first time. Enhanced electron-ion recombination is observed in two-neutrino double electron capture decays of $^{124}$Xe, representing a noteworthy new background. After removal of artificial signal-like events injected into the data set to mitigate analyzer bias, we find no evidence for an excess over expected backgrounds. World-leading constraints are placed on spin-independent (SI) and spin-dependent WIMP-nucleon cross sections for masses $\geq$9 GeV/$c^2$. The strongest SI exclusion set is $2.1\times10^{-48}$ cm$^{2}$ at the 90% confidence level at a mass of 36 GeV/$c^2$, and the best SI median sensitivity achieved is $5.0\times10^{-48}$ cm$^{2}$ for a mass of 40 GeV/$c^2$., Comment: 9 pages, 7 figures. See https://www.hepdata.net/record/155182 for a data release related to this paper
Published: 2024

6. STROBE-X High Energy Modular Array (HEMA)

Author: Hutcheson, Anthony L., Feroci, Marco, Argan, Andrea, Antonelli, Matias, Barbera, Marco, Bayer, Jorg, Bellutti, Pierluigi, Bertuccio, Giuseppe, Bonvicini, Valter, Cadoux, Franck, Campana, Riccardo, Vignali, Matteo Centis, Ceraudo, Francesco, Christophersen, Marc, Cirrincione, Daniela, D'Anca, Fabio, De Angelis, Nicolas, De Rosa, Alessandra, Della Casa, Giovanni, Del Monte, Ettore, Dilillo, Giuseppe, Evangelista, Yuri, Favre, Yannick, Ficorella, Francesco, Fiorini, Mauro, Ford, Jeremy J., Grassi, Marco, Grove, J. Eric, Guzman, Alejandro, Heddermann, Paul, Kole, Merlin R., Cicero, Ugo Lo, Lombardi, Giovanni, Malcovati, Piero, Michalska, Malgorzata, Meuris, Aline, Minervini, Gabriele, Nowosielski, Witold, Nuti, Alessio, Pacciani, Luigi, Pepponi, Giancarlo, Persyn, Steven C., Picciotto, Antonino, Pliego, Samuel, Rachevski, Alexander, Rashevskaya, Irina, Ray, Paul S., Samusenko, Alina, Santangelo, Andrea, Schanne, Stephane, Schwendeman, Carl L., Sleator, Clio, Smith, Jacob R., Sveda, Libor, Svoboda, Jiri, Tenzer, Christoph, Todaro, Michela, Trois, Alessio, Vacchi, Andrea, Xiong, Hao, Wang, Xianqi, Wu, Xin, Wulf, Eric A., Zampa, Gianluigi, Zampa, Nicola, Zdziarski, Andrzej, and Zorzi, Nicola
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The High Energy Modular Array (HEMA) is one of three instruments that compose the STROBE-X mission concept. The HEMA is a large-area, high-throughput non-imaging pointed instrument based on the Large Area Detector developed as part of the LOFT mission concept. It is designed for spectral timing measurements of a broad range of sources and provides a transformative increase in sensitivity to X-rays in the energy range of 2--30 keV compared to previous instruments, with an effective area of 3.4 m$^{2}$ at 8.5 keV and an energy resolution of better than 300 eV at 6 keV in its nominal field of regard., Comment: 16 pages, 10 figures
Published: 2024
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7. STROBE-X Mission Overview

Author: Ray, Paul S., Roming, Peter W. A., Argan, Andrea, Arzoumanian, Zaven, Ballantyne, David R., Bogdanov, Slavko, Bonvicini, Valter, Brandt, Terri J., Bursa, Michal, Cackett, Edward M., Chakrabarty, Deepto, Christophersen, Marc, Coderre, Kathleen M., De Geronimo, Gianluigi, Del Monte, Ettore, DeRosa, Alessandra, Dietz, Harley R., Evangelista, Yuri, Feroci, Marco, Ford, Jeremy J., Froning, Cynthia, Fryer, Christopher L., Gendreau, Keith C., Goldstein, Adam, Gonzalez, Anthony H., Hartmann, Dieter, Hernanz, Margarita, Hutcheson, Anthony, Zand, Jean in `t, Jenke, Peter, Kennea, Jamie, Lloyd-Ronning, Nicole M., Maccarone, Thomas J., Maes, Dominic, Markwardt, Craig B., Michalska, Malgorzata, Okajima, Takashi, Patruno, Alessandro, Persyn, Steven C., Phillips, Mark L., Prescod-Weinstein, Chanda, Redfern, Jillian A., Remillard, Ronald A., Santangelo, Andrea, Schwendeman, Carl L., Sleator, Clio, Steiner, James, Strohmayer, Tod E., Svoboda, Jiri, Tenzer, Christoph, Thompson, Steven P., Warwick, Richard W., Watts, Anna L., Wilson-Hodge, Colleen A., Wu, Xin, Wulf, Eric A., and Zampa, Gianluigi
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: We give an overview of the science objectives and mission design of the Spectroscopic Time-Resolving Observatory for Broadband Energy X-rays (STROBE-X) observatory, which has been proposed as a NASA probe-class (~$1.5B) mission in response to the Astro2020 recommendation for an X-ray probe., Comment: 11 pages, 5 figures, accepted for publication in JATIS
Published: 2024

8. Tiny Robotics Dataset and Benchmark for Continual Object Detection

Author: Pasti, Francesco, De Monte, Riccardo, Pezze, Davide Dalle, Susto, Gian Antonio, and Bellotto, Nicola
Subjects: Computer Science - Robotics, Computer Science - Computer Vision and Pattern Recognition
Abstract: Detecting objects in mobile robotics is crucial for numerous applications, from autonomous navigation to inspection. However, robots are often required to perform tasks in different domains with respect to the training one and need to adapt to these changes. Tiny mobile robots, subject to size, power, and computational constraints, encounter even more difficulties in running and adapting these algorithms. Such adaptability, though, is crucial for real-world deployment, where robots must operate effectively in dynamic and unpredictable settings. In this work, we introduce a novel benchmark to evaluate the continual learning capabilities of object detection systems in tiny robotic platforms. Our contributions include: (i) Tiny Robotics Object Detection (TiROD), a comprehensive dataset collected using a small mobile robot, designed to test the adaptability of object detectors across various domains and classes; (ii) an evaluation of state-of-the-art real-time object detectors combined with different continual learning strategies on this dataset, providing detailed insights into their performance and limitations; and (iii) we publish the data and the code to replicate the results to foster continuous advancements in this field. Our benchmark results indicate key challenges that must be addressed to advance the development of robust and efficient object detection systems for tiny robotics., Comment: Paper under review
Published: 2024

9. Replay Consolidation with Label Propagation for Continual Object Detection

Author: De Monte, Riccardo, Pezze, Davide Dalle, Ceccon, Marina, Pasti, Francesco, Paissan, Francesco, Farella, Elisabetta, Susto, Gian Antonio, and Bellotto, Nicola
Subjects: Computer Science - Computer Vision and Pattern Recognition, Computer Science - Artificial Intelligence
Abstract: Object Detection is a highly relevant computer vision problem with many applications such as robotics and autonomous driving. Continual Learning~(CL) considers a setting where a model incrementally learns new information while retaining previously acquired knowledge. This is particularly challenging since Deep Learning models tend to catastrophically forget old knowledge while training on new data. In particular, Continual Learning for Object Detection~(CLOD) poses additional difficulties compared to CL for Classification. In CLOD, images from previous tasks may contain unknown classes that could reappear labeled in future tasks. These missing annotations cause task interference issues for replay-based approaches. As a result, most works in the literature have focused on distillation-based approaches. However, these approaches are effective only when there is a strong overlap of classes across tasks. To address the issues of current methodologies, we propose a novel technique to solve CLOD called Replay Consolidation with Label Propagation for Object Detection (RCLPOD). Based on the replay method, our solution avoids task interference issues by enhancing the buffer memory samples. Our method is evaluated against existing techniques in CLOD literature, demonstrating its superior performance on established benchmarks like VOC and COCO.
Published: 2024

10. Read.Inquire.Write.: A Scaffolded Progression to Support Diverse Learners' Social Studies Argument Writing in Middle School

Author: Chauncey Monte-Sano and Ryan E. Hughes
Abstract: Middle school social studies teachers are increasingly working on argument writing in their classrooms so that students can successfully write counterarguments that acknowledge competing perspectives about historical and social issues by the end of eighth grade. The authors' prior research indicates that eighth-grade students "can" grow significantly in writing arguments and counterarguments with the support of their teachers' implementation of six 3-day inquiries that focused on compelling questions with multiple plausible responses, primary sources that represent two opposing perspectives, explicit instruction and guided practice in reading, analysis, and argument writing supported by tools. Yet the authors also saw that students who read below grade level and multilingual learners (MLLs) did not improve at the same rate as their peers who were more proficient in reading and English language, even though students' growth was still significant. The authors partnered with teachers to develop Read.Inquire.Write. (RIW), a curriculum that offers a scaffolded approach to support MLLs and students who benefit from greater literacy support in progressing toward the goal of writing effective social studies counterarguments over the course of three years. One key form of scaffolding that RIW introduces is a breakdown of social studies argument writing into three increasingly complex types -- interpretation, critique, and counterargument -- and a focus on one argument type per grade level in order to build the skills and understandings needed for successful counterargument over time. The argument types progress from one-sided arguments where students make a case for their interpretation of sources in sixth grade, to critiques of others' arguments in seventh, to developing two-sided arguments with counterarguments that rebut others' claims in eighth. The authors' purpose in this article is to share one aspect of the scaffolding the authors created -- the break down into three types of argument writing and progression in using them to build the skills needed for counterargument writing over time -- and how the writing of student Naseem, an MLL who read below grade level, developed in response to such scaffolding.
Published: 2024

11. Two-neutrino double electron capture of $^{124}$Xe in the first LUX-ZEPLIN exposure

Author: Aalbers, J., Akerib, D. S., Musalhi, A. K. Al, Alder, F., Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Baker, A., Balashov, S., Bang, J., Bargemann, J. W., Barillier, E. E., Beattie, K., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Bishop, E., Blockinger, G. M., Boxer, B., Brew, C. A. J., Brás, P., Burdin, S., Buuck, M., Carmona-Benitez, M. C., Carter, M., Chawla, A., Chen, H., Chin, Y. T., Chott, N. I., Converse, M. V., Coronel, R., Cottle, A., Cox, G., Curran, D., Dahl, C. E., David, A., Delgaudio, J., Dey, S., de Viveiros, L., Di Felice, L., Ding, C., Dobson, J. E. Y., Druszkiewicz, E., Dubey, S., Eriksen, S. R., Fan, A., Fearon, N. M., Fieldhouse, N., Fiorucci, S., Flaecher, H., Fraser, E. D., Fruth, T. M. A., Gaitskell, R. J., Geffre, A., Genovesi, J., Ghag, C., Gibbons, R., Gokhale, S., Green, J., van der Grinten, M. G. D., Haiston, J. J., Hall, C. R., Han, S., Hartigan-O'Connor, E., Haselschwardt, S. J., Hernandez, M. A., Hertel, S. A., Heuermann, G., Homenides, G. J., Horn, M., Huang, D. Q., Hunt, D., Jacquet, E., James, R. S., Johnson, J., Kaboth, A. C., Kamaha, A. C., Kannichankandy, M., Khaitan, D., Khazov, A., Khurana, I., Kim, J., Kim, Y. D., Kingston, J., Kirk, R., Kodroff, D., Korley, L., Korolkova, E. V., Kraus, H., Kravitz, S., Kreczko, L., Kudryavtsev, V. A., Leonard, D. S., Lesko, K. T., Levy, C., Lin, J., Lindote, A., Lippincott, W. H., Lopes, M. I., Lorenzon, W., Lu, C., Luitz, S., Majewski, P. A., Manalaysay, A., Mannino, R. L., Maupin, C., McCarthy, M. E., McDowell, G., McKinsey, D. N., McLaughlin, J., McLaughlin, J. B., McMonigle, R., Mizrachi, E., Monte, A., Monzani, M. E., Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naylor, A., Nelson, H. N., Neves, F., Nguyen, A., O'Brien, C. L., Olcina, I., Oliver-Mallory, K. C., Orpwood, J., Oyulmaz, K. Y, Palladino, K. J., Palmer, J., Pannifer, N. J., Parveen, N., Patton, S. J., Penning, B., Pereira, G., Perry, E., Pershing, T., Piepke, A., Qie, Y., Reichenbacher, J., Rhyne, C. A., Riffard, Q., Rischbieter, G. R. C., Ritchey, E., Riyat, H. S., Rosero, R., Rushton, T., Rynders, D., Santone, D., Sazzad, A. B. M. R., Schnee, R. W., Sehr, G., Shafer, B., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Siniscalco, J., Smith, R., Solovov, V. N., Sorensen, P., Soria, J., Stevens, A., Stifter, K., Suerfu, B., Sumner, T. J., Szydagis, M., Tiedt, D. R., Timalsina, M., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Vacheret, A., Vaitkus, A. C., Valentino, O., Velan, V., Wang, A., Wang, J. J., Wang, Y., Watson, J. R., Weeldreyer, L., Whitis, T. J., Wild, K., Williams, M., Wisniewski, W. J., Wolf, L., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Xia, Q., Xu, J., Xu, Y., Yeh, M., Yeum, D., Zha, W., and Zweig, E. A.
Subjects: Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract: The broad physics reach of the LUX-ZEPLIN (LZ) experiment covers rare phenomena beyond the direct detection of dark matter. We report precise measurements of the extremely rare decay of $^{124}$Xe through the process of two-neutrino double electron capture (2$\nu$2EC), utilizing a $1.39\,\mathrm{kg} \times \mathrm{yr}$ isotopic exposure from the first LZ science run. A half-life of $T_{1/2}^{2\nu2\mathrm{EC}} = (1.09 \pm 0.14_{\text{stat}} \pm 0.05_{\text{sys}}) \times 10^{22}\,\mathrm{yr}$ is observed with a statistical significance of $8.3\,\sigma$, in agreement with literature. First empirical measurements of the KK capture fraction relative to other K-shell modes were conducted, and demonstrate consistency with respect to recent signal models at the $1.4\,\sigma$ level., Comment: 15 pages, 3 figures
Published: 2024

12. Analysis of Crab X-ray Polarization using Deeper IXPE Observations

Author: Wong, Josephine, Mizuno, Tsunefumi, Bucciantini, Niccoló, Romani, Roger W., Yang, Yi-Jung, Liu, Kuan, Deng, Wei, Goya, Kazuho, Xie, Fei, Pilia, Maura, Kaaret, Philip, Weisskopf, Martin C., Silvestri, Stefano, Ng, C. -Y., Chen, Chien-Ting, Agudo, Iván, Antonelli, Lucio A., Bachetti, Matteo, Baldini, Luca, Baumgartner, Wayne H., Bellazzini, Ronaldo, Bianchi, Stefano, Bongiorno, Stephen D., Bonino, Raffaella, Brez, Alessandro, Capitanio, Fiamma, Castellano, Simone, Cavazzuti, Elisabetta, Ciprini, Stefano, Costa, Enrico, De Rosa, Alessandra, Del Monte, Ettore, Di Gesu, Laura, Di Lalla, Niccoló, Di Marco, Alessandro, Donnarumma, Immacolata, Doroshenko, Victor, Dovčiak, Michal, Ehlert, Steven R., Enoto, Teruaki, Evangelista, Yuri, Fabiani, Sergio, Ferrazzoli, Riccardo, Garcia, Javier A., Gunji, Shuichi, Heyl, Jeremy, Iwakiri, Wataru, Jorstad, Svetlana G., Karas, Vladimir, Kislat, Fabian, Kitaguchi, Takao, Kolodziejczak, Jeffery J., Krawczynski, Henric, La Monaca, Fabio, Latronico, Luca, Liodakis, Ioannis, Maldera, Simone, Manfreda, Alberto, Marin, Frédéric, Marinucci, Andrea, Marscher, Alan P., Marshall, Herman L., Massaro, Francesco, Matt, Giorgio, Mitsuishi, Ikuyuki, Muleri, Fabio, Negro, Michela, O'Dell, Stephen L., Omodei, Nicola, Oppedisano, Chiara, Papitto, Alessandro, Pavlov, George G., Peirson, Abel Lawrence, Perri, Matteo, Pesce-Rollins, Melissa, Petrucci, Pierre-Olivier, Possenti, Andrea, Poutanen, Juri, Puccetti, Simonetta, Ramsey, Brian D., Rankin, John, Ratheesh, Ajay, Roberts, Oliver J., Sgró, Carmelo, Slane, Patrick, Soffitta, Paolo, Spandre, Gloria, Swartz, Douglas A., Tamagawa, Toru, Tavecchio, Fabrizio, Taverna, Roberto, Tawara, Yuzuru, Tennant, Allyn F., Thomas, Nicholas E., Tombesi, Francesco, Trois, Alessio, Tsygankov, Sergey, Turolla, Roberto, Vink, Jacco, Wu, Kinwah, and Zane, Silvia
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present Crab X-ray polarization measurements using IXPE data with a total exposure of 300ks, three times more than the initial 2022 discovery paper. Polarization is detected in three times more pulsar phase bins, revealing an S-shaped $+40^\circ$ polarization angle sweep in the main pulse and ${>}1\sigma$ departures from the OPTIMA optical polarization in both pulses, suggesting different radiation mechanisms or sites for the polarized emission at the two wavebands. Our polarization map of the inner nebula reveals a toroidal magnetic field, as seen in prior IXPE analyses. Along the southern jet, the magnetic field orientation relative to the jet axis changes from perpendicular to parallel and the polarization degree decreases by ${\sim}6\%$. These observations may be explained by kink instabilities along the jet or a collision with a dense, jet-deflecting medium at the tip. Using spectropolarimetric analysis, we find asymmetric polarization in the four quadrants of the inner nebula, as expected for a toroidal field geometry, and a spatial correlation between polarization degree and photon index., Comment: 14 pages, 7 figures, 3 tables. Accepted by The Astrophysical Journal
Published: 2024

13. X-ray and multiwavelength polarization of Mrk 501 from 2022 to 2023

Author: Chen, Chien-Ting J., Liodakis, Ioannis, Middei, Riccardo, Kim, Dawoon E., Di Gesu, Laura, Di Marco, Alessandro, Ehlert, Steven R., Errando, Manel, Negro, Michela, Jorstad, Svetlana G., Marscher, Alan P., Wu, Kinwah, Agudo, Iván, Poutanen, Juri, Mizuno, Tsunefumi, Kouch, Pouya M., Lindfors, Elina, Borman, George A., Grishina, Tatiana S., Kopatskaya, Evgenia N., Larionova, Elena G., Morozova, Daria A., Savchenko, Sergey S., Troitsky, Ivan S., Troitskaya, Yulia V., Vasilyev, Andrey A., Zhovtan, Alexey V., Aceituno, Francisco José, Bonnoli, Giacomo, Casanova, Víctor, Escudero, Juan, Agís-González, Beatriz, Husillos, César, Santos, Jorge Otero, Sota, Alfredo, Piirola, Vilppu, Myserlis, Ioannis, Angelakis, Emmanouil, Kraus, Alexander, Gurwell, Mark, Keating, Garrett, Rao, Ramprasad, Kang, Sincheol, Lee, Sang-Sung, Kim, Sang-Hyun, Cheong, Whee Yeon, Jeong, Hyeon-Woo, Song, Chanwoo, Berdyugin, Andrei V., Kagitani, Masato, Kravtsov, Vadim, Nitindala, Anagha P., Sakanoi, Takeshi, Imazawa, Ryo, Sasada, Mahito, Fukazawa, Yasushi, Kawabata, Koji S., Uemura, Makoto, Nakaoka, Tatsuya, Akitaya, Hiroshi, Casadio, Carolina, Sievers, Albrecht, Antonelli, Lucio Angelo, Bachetti, Matteo, Baldini, Luca, Baumgartner, Wayne H., Bellazzini, Ronaldo, Bianchi, Stefano, Bongiorno, Stephen D., Bonino, Raffaella, Brez, Alessandro, Bucciantini, Niccoló, Capitanio, Fiamma, Castellano, Simone, Cavazzuti, Elisabetta, Ciprini, Stefano, Costa, Enrico, De Rosa, Alessandra, Del Monte, Ettore, Di Lalla, Niccoló, Donnarumma, Immacolata, Doroshenko, Victor, Dovčiak, Michal, Enoto, Teruaki, Evangelista, Yuri, Fabiani, Sergio, Ferrazzoli, Riccardo, Garcia, Javier A., Gunji, Shuichi, Hayashida, Kiyoshi, Heyl, Jeremy, Iwakiri, Wataru, Kaaret, Philip, Karas, Vladimir, Kislat, Fabian, Kitaguchi, Takao, Kolodziejczak, Jeffery J., Krawczynski, Henric, La Monaca, Fabio, Latronico, Luca, Maldera, Simone, Manfreda, Alberto, Marin, Frédéric, Marinucci, Andrea, Marshall, Herman L., Massaro, Francesco, Matt, Giorgio, Mitsuishi, Ikuyuki, Muleri, Fabio, Ng, C. -Y., O'Dell, Stephen L., Omodei, Nicola, Oppedisano, Chiara, Papitto, Alessandro, Pavlov, George G., Peirson, Abel Lawrence, Perri, Matteo, Pesce-Rollins, Melissa, Petrucci, Pierre-Olivier, Pilia, Maura, Possenti, Andrea, Puccetti, Simonetta, Ramsey, Brian D., Rankin, John, Ratheesh, Ajay, Roberts, Oliver J., Romani, Roger W., Sgró, Carmelo, Slane, Patrick, Soffitta, Paolo, Spandre, Gloria, Swartz, Douglas A., Tamagawa, Toru, Tavecchio, Fabrizio, Taverna, Roberto, Tawara, Yuzuru, Tennant, Allyn F., Thomas, Nicholas E., Tombesi, Francesco, Trois, Alessio, Tsygankov, Sergey S., Turolla, Roberto, Vink, Jacco, Weisskopf, Martin C., Xie, Fei, and Zane, Silvia
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies
Abstract: We present multiwavelength polarization measurements of the luminous blazar Mrk~501 over a 14-month period. The 2--8 keV X-ray polarization was measured with the Imaging X-ray Polarimetry Explorer (IXPE) with six 100-ks observations spanning from 2022 March to 2023 April. Each IXPE observation was accompanied by simultaneous X-ray data from NuSTAR, Swift/XRT, and/or XMM-Newton. Complementary optical-infrared polarization measurements were also available in the B, V, R, I, and J bands, as were radio polarization measurements from 4.85 GHz to 225.5 GHz. Among the first five IXPE observations, we did not find significant variability in the X-ray polarization degree and angle with IXPE. However, the most recent sixth observation found an elevated polarization degree at $>3\sigma$ above the average of the other five observations. The optical and radio measurements show no apparent correlations with the X-ray polarization properties. Throughout the six IXPE observations, the X-ray polarization degree remained higher than, or similar to, the R-band optical polarization degree, which remained higher than the radio value. This is consistent with the energy-stratified shock scenario proposed to explain the first two IXPE observations, in which the polarized X-ray, optical, and radio emission arises from different regions., Comment: Accepted for publication in ApJ
Published: 2024

14. The CUbesat Solar Polarimeter (CUSP) mission overview

Author: Fabiani, Sergio, Del Monte, Ettore, Baffo, Ilaria, Bonomo, Sergio, Brienza, Daniele, Campana, Riccardo, Centrone, Mauro, Contini, Gessica, Costa, Enrico, Cucinella, Giovanni, Curatolo, Andrea, De Angelis, Nicolas, De Cesare, Giovanni, Del Re, Andrea, Di Cosimo, Sergio, Di Filippo, Simone, Di Marco, Alessandro, Di Persio, Giuseppe, Donnarumma, Immacolata, Fanelli, Pierluigi, Leonetti, Paolo, Locarini, Alfredo, Loffredo, Pasqualino, Lombardi, Giovanni, Minervini, Gabriele, Modenini, Dario, Muleri, Fabio, Natalucci, Silvia, Negri, Andrea, Perelli, Massimo, Rossi, Monia, Rubini, Alda, Scalise, Emanuele, Soffitta, Paolo, Terracciano, Andrea, Tortora, Paolo, Zaccagnino, Emauele, and Zambardi, Alessandro
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Solar and Stellar Astrophysics, Physics - Space Physics
Abstract: The CUbesat Solar Polarimeter (CUSP) project is a future CubeSat mission orbiting the Earth aimed to measure the linear polarization of solar flares in the hard X-ray band, by means of a Compton scattering polarimeter. CUSP will allow us to study the magnetic reconnection and particle acceleration in the flaring magnetic structures of our star. The project is in the framework of the Italian Space Agency Alcor Program, which aims to develop new CubeSat missions. CUSP is approved for a Phase B study that will last for 12 months, starting in mid-2024. We report on the current status of the CUSP mission project as the outcome of the Phase A., Comment: Proceeding of SPIE Conference "Astronomical Telescopes+ Instrumentation", Yokohama (Japan), 16-21 June 2024. arXiv admin note: substantial text overlap with arXiv:2208.06211
Published: 2024

15. Towards imaging-spectro-polarimetry of solar flares in the X-rays

Author: Fabiani, Sergio, Rankin, John, Basso, Stefano, Costa, Enrico, Del Monte, Ettore, Desch, Klaus, Di Marco, Alessandro, Gruber, Markus, Kaminski, Jochen, Kim, Dawoon E., Imtiaz, Saba, Lefevre, Carlo, Loffredo, Pasqualino, Manikantan, Hemant, Morbidini, Alfredo, Muleri, Fabio, Pareschi, Giovanni, Plesanovs, Vladilavs, Ratheesh, Ajay, Rubini, Alda, Soffitta, Paolo, and Spiga, Daniele
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract: X-ray polarimetry of solar flares is still a not well established field of observation of our star. Past polarimeters were not able to measure with a high significance the polarization in X-rays from solar flares. Moreover, they had no imaging capabilities and measured only the polarization by integrating on all the image of the source. We propose a mission concept based on a gas photoelectric polarimeter, coupled with multilayer lobster-eye optics, to perform imaging-spectro-polarimetry of solar flares while monitoring the entire solar disc., Comment: Proceeding of SPIE Conference "Astronomical Telescopes+ Instrumentation", Yokohama (Japan), 16-21 June 2024
Published: 2024

16. Characterization of avalanche photodiodes (APDs) for the CUbesat Solar Polarimeter (CUSP) mission

Author: Cologgi, F., Alimenti, A., Fabiani, S., Torokthii, K., Silva, E., Del Monte, E., Baffo, I., Bonomo, S., Brienza, D., Campana, R., Centrone, M., Contini, G., Costa, E., Curatolo, A., Cucinella, G., DevAngelis, N., De Cesare, G., Del Re, A., Di Cosimo, S., Di Filippo, S., Di Marco, A., Di Persio, G., Donnarumma, I., Fanelli, P., Leonetti, P., Locarini, A., Loffredo, P., Lombardi, G., Minervini, G., Modenini, D., Muleri, F., Natalucci, S., Nigri, A., Perelli, M., Rossi, M., Rubini, A., Scalise, E., Soffitta, P., Terracciano, C., Tortora, P., Zaccagnino, E., and Zambardi, A.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Solar and Stellar Astrophysics, Physics - Space Physics
Abstract: The CUbesat Solar Polarimeter (CUSP) project is a CubeSat mission orbiting the Earth aimed to measure the linear polarization of solar flares in the hard X-ray band by means of a Compton scattering polarimeter. CUSP will allow the study of the magnetic reconnection and particle acceleration in the flaring magnetic structures of our star. CUSP is a project in the framework of the Alcor Program of the Italian Space Agency aimed at developing new CubeSat missions. It is approved for a Phase B study. In this work, we report on the characterization of the Avalanche Photodiodes (APDs) that will be used as readout sensors of the absorption stage of the Compton polarimeter. We assessed the APDs gain and energy resolution as a function of temperature by irradiating the sensor with a \textsuperscript{55}Fe radioactive source. Moreover, the APDs were also characterized as being coupled to a GAGG scintillator., Comment: Proceeding of SPIE Conference "Astronomical Telescopes+ Instrumentation", Yokohama (Japan), 16-21 June 2024
Published: 2024

17. The multi$-$physics analysis and design of CUSP, a two CubeSat constellation for Space Weather and Solar flares X-ray polarimetry

Author: Lombardi, Giovanni, Fabiani, Sergio, Del Monte, Ettore, Costa, Enrico, Soffitta, Paolo, Muleri, Fabio, Baffo, Ilaria, Biancolini, Marco E., Bonomo, Sergio, Brienza, Daniele, Campana, Riccardo, Centrone, Mauro, Contini, Gessica, Cucinella, Giovanni, Curatolo, Andrea, De Angelis, Nicolas, De Cesare, Giovanni, Del Re, Andrea, Di Cosimo, Sergio, Di Filippo, Simone, Di Marco, Alessandro, Di Meo, Emanuele, Di Persio, Giuseppe, Donnarumma, Immacolata, Fanelli, Pierluigi, Leonetti, Paolo, Locarini, Alfredo, Loffredo, Pasqualino, Lopez, Andrea, Minervini, Gabriele, Modenini, Dario, Natalucci, Silvia, Negri, Andrea, Perelli, Massimo, Rossi, Monia, Rubini, Alda, Scalise, Emanuele, Terracciano, Andrea, Tortora, Paolo, Zaccagnino, Emanuele, and Zambardi, Alessandro
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Solar and Stellar Astrophysics, Physics - Space Physics
Abstract: The CUbesat Solar Polarimeter (CUSP) project aims to develop a constellation of two CubeSats orbiting the Earth to measure the linear polarization of solar flares in the hard X-ray band by means of a Compton scattering polarimeter on board of each satellite. CUSP will allow to study the magnetic reconnection and particle acceleration in the flaring magnetic structures. CUSP is a project approved for a Phase B study by the Italian Space Agency in the framework of the Alcor program aimed to develop CubeSat technologies and missions. In this paper we describe the a method for a multi-physical simulation analysis while analyzing some possible design optimization of the payload design solutions adopted. In particular, we report the mechanical design for each structural component, the results of static and dynamic finite element analysis, the preliminary thermo-mechanical analysis for two specific thermal cases (hot and cold orbit) and a topological optimization of the interface between the platform and the payload., Comment: Proceeding of SPIE Conference "Astronomical Telescopes+ Instrumentation", Yokohama (Japan), 16-21 June 2024
Published: 2024

18. The evaluation of the CUSP scientific performance by a GEANT4 Monte Carlo simulation

Author: De Cesare, Giovanni, Fabiani, Sergio, Campana, Riccardo, Lombardi, Giovanni, Del Monte, Ettore, Costa, Enrico, Baffo, Ilaria, Bonomo, Sergio, Brienza, Daniele, Centrone, Mauro, Contini, Gessica, Cucinella, Giovanni, Curatolo, Andrea, De Angelis, Nicolas, Del Re, Andrea, Di Cosimo, Sergio, Di Filippo, Simone, Di Marco, Alessandro, Di Persio, Giuseppe, Donnarumma, Immacolata, Fanelli, Pierluigi, Leonetti, Paolo, Locarini, Alfredo, Loffredo, Pasqualino, Minervini, Gabriele, Modenini, Dario, Muleri, Fabio, Natalucci, Silvia, Negri, Andrea, Perelli, Massimo, Rossi, Monia, Rubini, Alda, Scalise, Emanuele, Soffitta, Paolo, Terracciano, Andrea, Tortora, Paolo, Zaccagnino, Emauele, and Zambardi, Alessandro
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Solar and Stellar Astrophysics, Physics - Space Physics
Abstract: The CUbesat Solar Polarimeter (CUSP) project is a CubeSat mission orbiting the Earth aimed to measure the linear polarization of solar flares in the hard X-ray band by means of a Compton scattering polarimeter. CUSP will allow to study the magnetic reconnection and particle acceleration in the flaring magnetic structures of our star. CUSP is a project in the framework of the Alcor Program of the Italian Space Agency aimed to develop new CubeSat missions. It is approved for a Phase B study. In this work, we report on the accurate simulation of the detector's response to evaluate the scientific performance. A GEANT4 Monte Carlo simulation is used to assess the physical interactions of the source photons with the detector and the passive materials. Using this approach, we implemented a detailed CUSP Mass Model. In this work, we report on the evaluation of the detector's effective area as a function of the beam energy., Comment: Proceeding of SPIE Conference "Astronomical Telescopes+ Instrumentation", Yokohama (Japan), 16-21 June 2024
Published: 2024

19. Linking microscopic structure to optical properties in soft plasmonic complexes

Author: Brasili, Francesco, Capocefalo, Angela, Del Monte, Giovanni, Rivas-Barbosa, Rodrigo, Pérez, Javier, Chauveau, Edouard, Bordi, Federico, Truzzolillo, Domenico, Zaccarelli, Emanuela, and Sennato, Simona
Subjects: Condensed Matter - Soft Condensed Matter, Physics - Optics
Abstract: The complexation of plasmonic nanoparticles (NPs) and thermoresponsive microgels is widely exploited for applications. Yet, a microscopic description of the mechanisms governing spatial organization of the NPs is still lacking. Combining small angle X-ray scattering, state-of-the-art numerical simulations and a simple toy model, we uncover how the volume phase transition of microgels drives NP-NP interactions, inducing NP progressive rearrangement with temperature. These results are directly compared to the extinction spectra of microgel-NPs complexes, allowing us to establish for the first time a microscopic link between plasmon coupling and NP local structure.
Published: 2024

20. An IXPE-Led X-ray Spectro-Polarimetric Campaign on the Soft State of Cygnus X-1: X-ray Polarimetric Evidence for Strong Gravitational Lensing

Author: Steiner, James F., Nathan, Edward, Hu, Kun, Krawczynski, Henric, Dovciak, Michal, Veledina, Alexandra, Muleri, Fabio, Svoboda, Jiri, Alabarta, Kevin, Parra, Maxime, Bhargava, Yash, Matt, Giorgio, Poutanen, Juri, Petrucci, Pierre-Olivier, Tennant, Allyn F., Baglio, M. Cristina, Baldini, Luca, Barnier, Samuel, Bhattacharyya, Sudip, Bianchi, Stefano, Brigitte, Maimouna, Cabezas, Mauricio, Cangemi, Floriane, Capitanio, Fiamma, Casey, Jacob, Cavero, Nicole Rodriguez, Castellano, Simone, Cavazzuti, Elisabetta, Chun, Sohee, Churazov, Eugene, Costa, Enrico, Di Lalla, Niccolo, Di Marco, Alessandro, Egron, Elise, Ewing, Melissa, Fabiani, Sergio, Garcia, Javier A., Green, David A., Grinberg, Victoria, Hadrava, Petr, Ingram, Adam, Kaaret, Philip, Kislat, Fabian, Kitaguchi, Takao, Kravtsov, Vadim, Kubatova, Brankica, La Monaca, Fabio, Latronico, Luca, Loktev, Vladislav, Malacaria, Christian, Marin, Frederic, Marinucci, Andrea, Maryeva, Olga, Mastroserio, Guglielmo, Mizuno, Tsunefumi, Negro, Michela, Omodei, Nicola, Podgorny, Jakub, Rankin, John, Ratheesh, Ajay, Rhodes, Lauren, Russell, David M., Slechta, Miroslav, Soffitta, Paolo, Spooner, Sean, Suleimanov, Valery, Tombesi, Francesco, Trushkin, Sergei A., Weisskopf, Martin C., Zane, Silvia, Zdziarski, Andrzej A., Zhang, Sixuan, Zhang, Wenda, Zhou, Menglei, Agudo, Ivan, Antonelli, Lucio A., Bachetti, Matteo, Baumgartner, Wayne H., Bellazzini, Ronaldo, Bongiorno, Stephen D., Bonino, Raffaella, Brez, Alessandro, Bucciantini, Niccolo, Chen, Chien-Ting, Ciprini, Stefano, De Rosa, Alessandra, Del Monte, Ettore, Di Gesu, Laura, Donnarumma, Immacolata, Doroshenko, Victor, Ehlert, Steven R., Enoto, Teruaki, Evangelista, Yuri, Ferrazzoli, Riccardo, Gunji, Shuichi, Hayashida, Kiyoshi, Heyl, Jeremy, Iwakiri, Wataru, Jorstad, Svetlana G., Karas, Vladimir, Kolodziejczak, Jeffery J., Liodakis, Ioannis, Maldera, Simone, Manfreda, Alberto, Marscher, Alan P., Marshall, Herman L., Massaro, Francesco, Mitsuishi, Ikuyuki, Ng, Chi-Yung, O'Dell, Stephen L., Oppedisano, Chiara, Papitto, Alessandro, Pavlov, George G., Peirson, Abel L., Perri, Matteo, Pesce-Rollins, Melissa, Pilia, Maura, Possenti, Andrea, Puccetti, Simonetta, Ramsey, Brian D., Roberts, Oliver J., Romani, Roger W., Sgro, Carmelo, Slane, Patrick, Spandre, Gloria, Swartz, Douglas A., Tamagawa, Toru, Tavecchio, Fabrizio, Taverna, Roberto, Tawara, Yuzuru, Thomas, Nicholas E., Trois, Alessio, Tsygankov, Sergey S., Turolla, Roberto, Vink, Jacco, Wu, Kinwah, and Xie, Fei
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present the first X-ray spectropolarimetric results for Cygnus X-1 in its soft state from a campaign of five IXPE observations conducted during 2023 May-June. Companion multiwavelength data during the campaign are likewise shown. The 2-8 keV X-rays exhibit a net polarization degree PD=1.99%+/-0.13% (68% confidence). The polarization signal is found to increase with energy across IXPE's 2-8 keV bandpass. The polarized X-rays exhibit an energy-independent polarization angle of PA=-25.7+/-1.8 deg. East of North (68% confidence). This is consistent with being aligned to Cyg X-1's AU-scale compact radio jet and its pc-scale radio lobes. In comparison to earlier hard-state observations, the soft state exhibits a factor of 2 lower polarization degree, but a similar trend with energy and a similar (also energy-independent) position angle. When scaling by the natural unit of the disk temperature, we find the appearance of a consistent trendline in the polarization degree between soft and hard states. Our favored polarimetric model indicates Cyg X-1's spin is likely high (a* above ~0.96). The substantial X-ray polarization in Cyg X-1's soft state is most readily explained as resulting from a large portion of X-rays emitted from the disk returning and reflecting off the disk surface, generating a high polarization degree and a polarization direction parallel to the black hole spin axis and radio jet. In IXPE's bandpass, the polarization signal is dominated by the returning reflection emission. This constitutes polarimetric evidence for strong gravitational lensing of X-rays close to the black hole., Comment: 20 pages, accepted for publication in ApJL
Published: 2024

21. Sycophancy to Subterfuge: Investigating Reward-Tampering in Large Language Models

Author: Denison, Carson, MacDiarmid, Monte, Barez, Fazl, Duvenaud, David, Kravec, Shauna, Marks, Samuel, Schiefer, Nicholas, Soklaski, Ryan, Tamkin, Alex, Kaplan, Jared, Shlegeris, Buck, Bowman, Samuel R., Perez, Ethan, and Hubinger, Evan
Subjects: Computer Science - Artificial Intelligence, Computer Science - Computation and Language
Abstract: In reinforcement learning, specification gaming occurs when AI systems learn undesired behaviors that are highly rewarded due to misspecified training goals. Specification gaming can range from simple behaviors like sycophancy to sophisticated and pernicious behaviors like reward-tampering, where a model directly modifies its own reward mechanism. However, these more pernicious behaviors may be too complex to be discovered via exploration. In this paper, we study whether Large Language Model (LLM) assistants which find easily discovered forms of specification gaming will generalize to perform rarer and more blatant forms, up to and including reward-tampering. We construct a curriculum of increasingly sophisticated gameable environments and find that training on early-curriculum environments leads to more specification gaming on remaining environments. Strikingly, a small but non-negligible proportion of the time, LLM assistants trained on the full curriculum generalize zero-shot to directly rewriting their own reward function. Retraining an LLM not to game early-curriculum environments mitigates, but does not eliminate, reward-tampering in later environments. Moreover, adding harmlessness training to our gameable environments does not prevent reward-tampering. These results demonstrate that LLMs can generalize from common forms of specification gaming to more pernicious reward tampering and that such behavior may be nontrivial to remove., Comment: Make it easier to find samples from the model, and highlight that our operational definition of reward tampering has false positives where the model attempts to complete the task honestly but edits the reward. Add paragraph to conclusion to this effect, and add sentence to figure 1 to this effect
Published: 2024

22. Probing the polarized emission from SMC X-1: the brightest X-ray pulsar observed by IXPE

Author: Forsblom, Sofia V., Tsygankov, Sergey S., Poutanen, Juri, Doroshenko, Victor, Mushtukov, Alexander A., Ng, Mason, Ravi, Swati, Marshall, Herman L., Di Marco, Alessandro, La Monaca, Fabio, Malacaria, Christian, Mastroserio, Guglielmo, Loktev, Vladislav, Possenti, Andrea, Suleimanov, Valery F., Taverna, Roberto, Agudo, Ivan, Antonelli, Lucio A., Bachetti, Matteo, Baldini, Luca, Baumgartner, Wayne H., Bellazzini, Ronaldo, Bianchi, Stefano, Bongiorno, Stephen D., Bonino, Raffaella, Brez, Alessandro, Bucciantini, Niccolo, Capitanio, Fiamma, Castellano, Simone, Cavazzuti, Elisabetta, Chen, Chien-Ting, Ciprini, Stefano, Costa, Enrico, De Rosa, Alessandra, Del Monte, Ettore, Di Gesu, Laura, Di Lalla, Niccolo, Donnarumma, Immacolata, Dovciak, Michal, Ehlert, Steven R., Enoto, Teruaki, Evangelista, Yuri, Fabiani, Sergio, Ferrazzoli, Riccardo, Garcia, Javier A., Gunji, Shuichi, Hayashida, Kiyoshi, Heyl, Jeremy, Iwakiri, Wataru, Jorstad, Svetlana G., Kaaret, Philip, Karas, Vladimir, Kislat, Fabian, Kitaguchi, Takao, Kolodziejczak, Jeffery J., Krawczynski, Henric, Latronico, Luca, Liodakis, Ioannis, Maldera, Simone, Manfreda, Alberto, Marin, Frederic, Marinucci, Andrea, Marscher, Alan P., Massaro, Francesco, Matt, Giorgio, Mitsuishi, Ikuyuki, Mizuno, Tsunefumi, Muleri, Fabio, Negro, Michela, Ng, Chi-Yung, O'Dell, Stephen L., Omodei, Nicola, Oppedisano, Chiara, Papitto, Alessandro, Pavlov, George G., Peirson, Abel L., Perri, Matteo, Pesce-Rollins, Melissa, Petrucci, Pierre-Olivier, Pilia, Maura, Puccetti, Simonetta, Ramsey, Brian D., Rankin, John, Ratheesh, Ajay, Roberts, Oliver J., Romani, Roger W., Sgro, Carmelo, Slane, Patrick, Soffitta, Paolo, Spandre, Gloria, Swartz, Douglas A., Tamagawa, Toru, Tavecchio, Fabrizio, Tawara, Yuzuru, Tennant, Allyn F., Thomas, Nicholas E., Tombesi, Francesco, Trois, Alessio, Turolla, Roberto, Vink, Jacco, Weisskopf, Martin C., Wu, Kinwah, Xie, Fei, and Zane, Silvia
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Recent observations of X-ray pulsars (XRPs) performed by the Imaging X-ray Polarimetry Explorer (IXPE) have made it possible to investigate the intricate details of these objects in a new way, thanks to the added value of X-ray polarimetry. Here we present the results of the IXPE observations of SMC X-1, a member of the small group of XRPs displaying super-orbital variability. SMC X-1 was observed by IXPE three separate times during the high state of its super-orbital period. The observed luminosity in the 2-8 keV energy band of $L=2\times10^{38}$ erg/s makes SMC X-1 the brightest XRP ever observed by IXPE. We detect significant polarization in all three observations, with values of the phase-averaged polarization degree (PD) and polarization angle (PA) of $3.2\pm0.8$% and $97\deg\pm8\deg$ for Observation 1, $3.0\pm0.9$% and $90\deg\pm8\deg$ for Observation 2, and $5.5\pm1.1$% and $80\deg\pm6\deg$ for Observation 3, for the spectro-polarimetric analysis. The observed PD shows an increase over time with decreasing luminosity, while the PA decreases in decrements of 10\deg. The phase-resolved spectro-polarimetric analysis reveals significant detection of polarization in three out of seven phase bins, with the PD ranging between 2% and 10%, and a corresponding range in the PA from $\sim$70\deg\ to $\sim$100\deg. The pulse-phase resolved PD displays an apparent anti-correlation with the flux. Using the rotating vector model, we obtain constraints on the pulsar's geometrical properties for the individual observations. The position angle of the pulsar displays an evolution over time supporting the idea that we observe changes related to different super-orbital phases. Scattering in the wind of the precessing accretion disk may be responsible for the behavior of the polarimetric properties observed during the high-state of SMC X-1's super-orbital period., Comment: 11 pages, 11 figures, submitted to A&A
Published: 2024

23. Probing the Scalar WIMP-Pion Coupling with the first LUX-ZEPLIN data

Author: Aalbers, J., Akerib, D. S., Musalhi, A. K. Al, Alder, F., Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Baker, A., Balashov, S., Bang, J., Barillier, E. E., Bargemann, J. W., Beattie, K., Benson, T., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Bishop, E. J., Blockinger, G. M., Boxer, B., Brew, C. A. J., Brás, P., Burdin, S., Buuck, M., Carmona-Benitez, M. C., Carter, M., Chawla, A., Chen, H., Cherwinka, J. J., Chin, Y. T., Chott, N. I., Converse, M. V., Cottle, A., Cox, G., Curran, D., Dahl, C. E., David, A., Delgaudio, J., Dey, S., deViveiros, L., DiFelice, L., Ding, C., Dobson, J. E. Y., Druszkiewicz, E., Eriksen, S. R., Fan, A., Fearon, N. M., Fiorucci, S., Flaecher, H., Fraser, E. D., Fruth, T. M. A., Gaitskell, R. J., Geffre, A., Genovesi, J., Ghag, C., Gibbons, R., Gokhale, S., Green, J., vanderGrinten, M. G. D., Haiston, J. J., Hall, C. R., Han, S., Hartigan-O'Connor, E., Haselschwardt, S. J., Hernandez, M. A., Hertel, S. A., Heuermann, G., Homenides, G. J., Horn, M., Huang, D. Q., Hunt, D., Jacquet, E., James, R. S., Johnson, J., Kaboth, A. C., Kamaha, A. C., Kannichankandy, M., Khaitan, D., Khazov, A., Khurana, I., DKim, J., Kim, J., Kingston, J., Kirk, R., Kodroff, D., Korley, L., Korolkova, E. V., Kraus, H., Kravitz, S., Kreczko, L., Kudryavtsev, V. A., Leonard, D. S., Lesko, K. T., Levy, C., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Lopes, M. I., Lorenzon, W., Lu, C., Luitz, S., Majewski, P. A., Manalaysay, A., Mannino, R. L., Maupin, C., McCarthy, M. E., McDowell, G., McKinsey, D. N., McLaughlin, J., McLaughlin, J. B., McMonigle, R., Miller, E. H., Mizrachi, E., Monte, A., Monzani, M. E., Mendoza, J. D. Morales, Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naylor, A., Nelson, H. N., Neves, F., Nguyen, A., Nikoleyczik, J. A., Olcina, I., Oliver-Mallory, K. C., Orpwood, J., Palladino, K. J., Palmer, J., Pannifer, N. J., Parveen, N., Patton, S. J., Penning, B., Pereira, G., Perry, E., Pershing, T., Piepke, A., Qie, Y., Reichenbacher, J., Rhyne, C. A., Riffard, Q., Rischbieter, G. R. C., Riyat, H. S., Rosero, R., Rushton, T., Rynders, D., Santone, D., Sazzad, A. B. M. R., Schnee, R. W., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Siniscalco, J., Smith, R., Solovov, V. N., Sorensen, P., Soria, J., Stancu, I., Stevens, A., Stifter, K., Suerfu, B., Sumner, T. J., Szydagis, M., Taylor, W. C., Tiedt, D. R., Timalsina, M., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Tronstad, D. R., Vacheret, A., Vaitkus, A. C., Valentino, O., Velan, V., Wang, A., Wang, J. J., Wang, Y., Watson, J. R., Webb, R. C., Weeldreyer, L., Whitis, T. J., Williams, M., Wisniewski, W. J., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Xia, Q., Xiang, X., Xu, J., Yeh, M., and Zweig, E. A.
Subjects: High Energy Physics - Experiment
Abstract: Weakly interacting massive particles (WIMPs) may interact with a virtual pion that is exchanged between nucleons. This interaction channel is important to consider in models where the spin-independent isoscalar channel is suppressed. Using data from the first science run of the LUX-ZEPLIN dark matter experiment, containing 60 live days of data in a 5.5~tonne fiducial mass of liquid xenon, we report the results on a search for WIMP-pion interactions. We observe no significant excess and set an upper limit of $1.5\times10^{-46}$~cm$^2$ at a 90\% confidence level for a WIMP mass of 33~GeV/c$^2$ for this interaction.
Published: 2024
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24. IXPE observation of PKS 2155-304 reveals the most highly polarized blazar

Author: Kouch, Pouya M., Liodakis, Ioannis, Middei, Riccardo, Kim, Dawoon E., Tavecchio, Fabrizio, Marscher, Alan P., Marshall, Herman L., Ehlert, Steven R., Di Gesu, Laura, Jorstad, Svetlana G., Agudo, Iván, Madejski, Grzegorz M., Romani, Roger W., Errando, Manel, Lindfors, Elina, Nilsson, Kari, Toppari, Ella, Potter, Stephen B., Imazawa, Ryo, Sasada, Mahito, Fukazawa, Yasushi, Kawabata, Koji S., Uemura, Makoto, Mizuno, Tsunefumi, Nakaoka, Tatsuya, Akitaya, Hiroshi, McCall, Callum, Jermak, Helen E., Steele, Iain A., Myserlis, Ioannis, Gurwell, Mark, Keating, Garrett K., Rao, Ramprasad, Kang, Sincheol, Lee, Sang-Sung, Kim, Sang-Hyun, Cheong, Whee Yeon, Jeong, Hyeon-Woo, Angelakis, Emmanouil, Kraus, Alexander, Aceituno, Francisco José, Bonnoli, Giacomo, Casanova, Víctor, Escudero, Juan, Agís-González, Beatriz, Husillos, César, Morcuende, Daniel, Otero-Santos, Jorge, Sota, Alfredo, Bachev, Rumen, Antonelli, Lucio Angelo, Bachetti, Matteo, Baldini, Luca, Baumgartner, Wayne H., Bellazzini, Ronaldo, Bianchi, Stefano, Bongiorno, Stephen D., Bonino, Raffaella, Brez, Alessandro, Bucciantini, Niccolò, Capitanio, Fiamma, Castellano, Simone, Cavazzuti, Elisabetta, Chen, Chien-Ting, Ciprini, Stefano, Costa, Enrico, De Rosa, Alessandra, Del Monte, Ettore, Di Lalla, Niccolò, Di Marco, Alessandro, Donnarumma, Immacolata, Doroshenko, Victor, Dovčiak, Michal, Enoto, Teruaki, Evangelista, Yuri, Fabiani, Sergio, Ferrazzoli, Riccardo, Garcia, Javier A., Gunji, Shuichi, Hayashida, Kiyoshi, Heyl, Jeremy, Iwakiri, Wataru, Kaaret, Philip, Karas, Vladimir, Kislat, Fabian, Kitaguchi, Takao, Kolodziejczak, Jeffery J., Krawczynski, Henric, La Monaca, Fabio, Latronico, Luca, Maldera, Simone, Manfreda, Alberto, Marin, Frédéric, Marinucci, Andrea, Massaro, Francesco, Matt, Giorgio, Mitsuishi, Ikuyuki, Muleri, Fabio, Negro, Michela, Ng, C. -Y., O'Dell, Stephen L., Omodei, Nicola, Oppedisano, Chiara, Papitto, Alessandro, Pavlov, George G., Peirson, Abel Lawrence, Perri, Matteo, Pesce-Rollins, Melissa, Petrucci, Pierre-Olivier, Pilia, Maura, Possenti, Andrea, Poutanen, Juri, Puccetti, Simonetta, Ramsey, Brian D., Rankin, John, Ratheesh, Ajay, Roberts, Oliver J., Sgrò, Carmelo, Slane, Patrick, Soffitta, Paolo, Spandre, Gloria, Swartz, Douglas A., Tamagawa, Toru, Taverna, Roberto, Tawara, Yuzuru, Tennant, Allyn F., Thomas, Nicholas E., Tombesi, Francesco, Trois, Alessio, Tsygankov, Sergey S., Turolla, Roberto, Vink, Jacco, Weisskopf, Martin C., Wu, Kinwah, Xie, Fei, and Zane, Silvia
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: We report the X-ray polarization properties of the high-synchrotron-peaked (HSP) blazar PKS 2155$-$304 based on observations with the Imaging X-ray Polarimetry Explorer (IXPE). We observed the source between Oct 27 and Nov 7, 2023. We also conducted an extensive contemporaneous multiwavelength (MW) campaign. We find that during the first half ($T_1$) of the IXPE pointing, the source exhibited the highest X-ray polarization degree detected for an HSP blazar thus far, (30.7$\pm$2.0)%, which dropped to (15.3$\pm$2.1)% during the second half ($T_2$). The X-ray polarization angle remained stable during the IXPE pointing at 129.4$^\circ$$\pm$1.8$^\circ$ and 125.4$^\circ$$\pm$3.9$^\circ$ during $T_1$ and $T_2$, respectively. Meanwhile, the optical polarization degree remained stable during the IXPE pointing, with average host-galaxy-corrected values of (4.3$\pm$0.7)% and (3.8$\pm$0.9)% during the $T_1$ and $T_2$, respectively. During the IXPE pointing, the optical polarization angle changed achromatically from $\sim$140$^\circ$ to $\sim$90$^\circ$ and back to $\sim$130$^\circ$. Despite several attempts, we only detected (99.7% conf.) the radio polarization once (during $T_2$, at 225.5 GHz): with degree (1.7$\pm$0.4)% and angle 112.5$^\circ$$\pm$5.5$^\circ$. The direction of the broad pc-scale jet is rather ambiguous and has been found to point to the east and south at different epochs; however, on larger scales (> 1.5 pc) the jet points toward the southeast ($\sim$135$^\circ$), similar to all of the MW polarization angles. Moreover, the X-ray to optical polarization degree ratios of $\sim$7 and $\sim$4 during $T_1$ and $T_2$, respectively, are similar to previous IXPE results for several HSP blazars. These findings, combined with the lack of correlation of temporal variability between the MW polarization properties, agree with an energy-stratified shock-acceleration scenario in HSP blazars., Comment: 17 pages, 10 figures, 4 tables, Accepted for publication in A&A
Published: 2024
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25. Probing the scalar WIMP-pion coupling with the first LUX-ZEPLIN data

Author: Zweig, EA, Yeh, M, Xu, J, Xiang, X, Xia, Q, Wright, CJ, Woodward, D, Woodford, S, Wolfs, FLH, Wisniewski, WJ, Williams, M, Whitis, TJ, Weeldreyer, L, Webb, RC, Watson, JR, Wang, Y, Wang, JJ, Wang, A, Velan, V, Valentino, O, Vaitkus, AC, Vacheret, A, Tronstad, DR, Tripathi, M, Trask, M, Tranter, J, Tovey, DR, Tong, Z, Timalsina, M, Tiedt, DR, Taylor, WC, Szydagis, M, Sumner, TJ, Suerfu, B, Stifter, K, Stevens, A, Stancu, I, Soria, J, Sorensen, P, Solovov, VN, Smith, R, Siniscalco, J, Sinev, G, Silva, C, Silk, JJ, Shutt, T, Shaw, S, Schnee, RW, Sazzad, ABMR, Santone, D, Rynders, D, Rushton, T, Rosero, R, Riyat, HS, Rischbieter, GRC, Riffard, Q, Rhyne, CA, Reichenbacher, J, Qie, Y, Piepke, A, Pershing, T, Perry, E, Pereira, G, Penning, B, Patton, SJ, Parveen, N, Pannifer, NJ, Palmer, J, Palladino, KJ, Orpwood, J, Oliver-Mallory, KC, Olcina, I, Nikoleyczik, JA, Nguyen, A, Neves, F, Nelson, HN, Naylor, A, Murphy, ASJ, Murdy, M, Mount, BJ, Morrison, E, Morales Mendoza, JD, Monzani, ME, Monte, A, Mizrachi, E, Miller, EH, McMonigle, R, McLaughlin, JB, McLaughlin, J, McKinsey, DN, McDowell, G, McCarthy, ME, Maupin, C, Mannino, RL, Manalaysay, A, Majewski, PA, Luitz, S, Lu, C, Lorenzon, W, and Lopes, MI
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Engineering, Mathematical sciences, Physical sciences
Abstract: Weakly interacting massive particles (WIMPs) may interact with a virtual pion that is exchanged between nucleons. This interaction channel is important to consider in models where the spin-independent isoscalar channel is suppressed. Using data from the first science run of the LUX-ZEPLIN dark matter experiment, containing 60 live days of data in a 5.5 tonne fiducial mass of liquid xenon, we report the results on a search for WIMP-pion interactions. We observe no significant excess and set an upper limit of 1.5 × 10−46 cm2 at a 90% confidence level for a WIMP mass of 33 GeV/c2 for this interaction.
Published: 2024

26. Monodromies of Second Order $q$-difference Equations from the WKB Approximation

Author: Del Monte, Fabrizio and Longhi, Pietro
Subjects: Mathematical Physics, High Energy Physics - Theory
Abstract: This paper studies the space of monodromy data of second order $q$-difference equations through the framework of WKB analysis. We compute the connection matrices associated to the Stokes phenomenon of WKB wavefunctions and develop a general framework to parameterize monodromies of $q$-difference equations. Computations of monodromies are illustrated with explicit examples, including a $q$-Mathieu equation and its degenerations. In all examples we show that the monodromy around the origin of $\mathbb{C}^*$ admits an expansion in terms of Voros symbols, or exponentiated quantum periods, with integer coefficients. Physically these monodromies correspond to expectation values of Wilson line operators in five dimensional quantum field theories with minimal supersymmetry. In the case of the $q$-Mathieu equation, we show that the trace of the monodromy can be identified with the Hamiltonian of a corresponding $q$-Painlev\'e equation., Comment: 58 pages
Published: 2024

27. The Data Acquisition System of the LZ Dark Matter Detector: FADR

Author: Aalbers, J., Akerib, D. S., Musalhi, A. K. Al, Alder, F., Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Baker, A., Balashov, S., Bang, J., Barillier, E. E., Bargemann, J. W., Beattie, K., Benson, T., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Bishop, E., Blockinger, G. M., Boxer, B., Brew, C. A. J., Brás, P., Buckley, J. H., Burdin, S., Buuck, M., Carmona-Benitez, M. C., Carter, M., Chawla, A., Chen, H., Cherwinka, J. J., Chin, Y. T., Chott, N. I., Converse, M. V., Cottle, A., Cox, G., Curran, D., Dahl, C. E., David, A., Delgaudio, J., Dey, S., de Viveiros, L., Di Felice, L., Dimino, T., Ding, C., Dobson, J. E. Y., Druszkiewicz, E., Eriksen, S. R., Fan, A., Fearon, N. M., Fieldhouse, N., Fiorucci, S., Flaecher, H., Fraser, E. D., Fruth, T. M. A., Gaitskell, R. J., Geffre, A., Gelfand, R., Genovesi, J., Ghag, C., Gibbons, R., Gokhale, S., Green, J., van der Grinten, M. G. D., Haiston, J. J., Hall, C. R., Han, S., Hartigan-O'Connor, E., Haselschwardt, S. J., Hernandez, M. A., Hertel, S. A., Heuermann, G., Homenides, G. J., Horn, M., Huang, D. Q., Hunt, D., Jacquet, E., James, R. S., Johnson, J., Kaboth, A. C., Kamaha, A. C., Kannichankandy, M., Khaitan, D., Khazov, A., Khurana, I., Kim, J., Kim, Y. D., Kingston, J., Kirk, R., Kodroff, D., Korley, L., Korolkova, E. V., Koyuncu, M., Kraus, H., Kravitz, S., Kreczko, L., Kudryavtsev, V. A., Leonard, D. S., Lesko, K. T., Levy, C., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Loniewski, C., Lopes, M. I., Lorenzon, W., Lu, C., Luitz, S., Majewski, P. A., Manalaysay, A., Mannino, R. L., Maupin, C., McCarthy, M. E., McDowell, G., McKinsey, D. N., McLaughlin, J., Mclaughlin, J. B., McMonigle, R., Miller, E. H., Mizrachi, E., Monte, A., Monzani, M. E., Moongweluwan, M., Mendoza, J. D. Morales, Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naylor, A., Nelson, H. N., Neves, F., Nguyen, A., Nikoleyczik, J. A., Oh, H., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Orpwood, J., Palladino, K. J., Palmer, J., Pannifer, N. J., Parveen, N., Patton, S. J., Penning, B., Pereira, G., Perry, E., Pershing, T., Piepke, A., Qie, Y., Reichenbacher, J., Rhyne, C. A., Riffard, Q., Rischbieter, G. R. C., Riyat, H. S., Rosero, R., Rushton, T., Rynders, D., Santone, D., Sarkis, R., Sazzad, A. B. M. R., Schnee, R. W., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Siniscalco, J., Skulski, W., Smith, R., Solovov, V. N., Sorensen, P., Soria, J., Stancu, I., Stevens, A., Stifter, K., Suerfu, B., Sumner, T. J., Szydagis, M., Taylor, W. C., Tiedt, D. R., Timalsina, M., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Tronstad, D. R., Vacheret, A., Vaitkus, A. C., Vaitkus, J., Valentino, O., Velan, V., Wang, A., Wang, J. J., Wang, Y., Watson, J. R., Webb, R. C., Weeldreyer, L., Whitis, T. J., Williams, M., Wisniewski, W. J., Wolfs, F. L. H., Wolfs, J. D., Woodford, S., Woodward, D., Wright, C. J., Xia, Q., Xiang, X., Xu, J., Yeh, M., and Yin, J.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The Data Acquisition System (DAQ) for the LUX-ZEPLIN (LZ) dark matter detector is described. The signals from 745 PMTs, distributed across three subsystems, are sampled with 100-MHz 32-channel digitizers (DDC-32s). A basic waveform analysis is carried out on the on-board Field Programmable Gate Arrays (FPGAs) to extract information about the observed scintillation and electroluminescence signals. This information is used to determine if the digitized waveforms should be preserved for offline analysis. The system is designed around the Kintex-7 FPGA. In addition to digitizing the PMT signals and providing basic event selection in real time, the flexibility provided by the use of FPGAs allows us to monitor the performance of the detector and the DAQ in parallel to normal data acquisition. The hardware and software/firmware of this FPGA-based Architecture for Data acquisition and Realtime monitoring (FADR) are discussed and performance measurements are described., Comment: 18 pages, 24 figures
Published: 2024

28. Studying geometry of the ultraluminous X-ray pulsar Swift J0243.6+6124 using X-ray and optical polarimetry

Author: Poutanen, Juri, Tsygankov, Sergey S., Doroshenko, Victor, Forsblom, Sofia V., Jenke, Peter, Kaaret, Philip, Berdyugin, Andrei V., Blinov, Dmitry, Kravtsov, Vadim, Liodakis, Ioannis, Tzouvanou, Anastasia, Di Marco, Alessandro, Heyl, Jeremy, La Monaca, Fabio, Mushtukov, Alexander A., Pavlov, George G., Salganik, Alexander, Veledina, Alexandra, Weisskopf, Martin C., Zane, Silvia, Loktev, Vladislav, Suleimanov, Valery F., Wilson-Hodge, Colleen, Berdyugina, Svetlana V., Kagitani, Masato, Piirola, Vilppu, Sakanoi, Takeshi, Agudo, Ivan, Antonelli, Lucio A., Bachetti, Matteo, Baldini, Luca, Baumgartner, Wayne H., Bellazzini, Ronaldo, Bianchi, Stefano, Bongiorno, Stephen D., Bonino, Raffaella, Brez, Alessandro, Bucciantini, Niccolo, Capitanio, Fiamma, Castellano, Simone, Cavazzuti, Elisabetta, Chen, Chien-Ting, Ciprini, Stefano, Costa, Enrico, De Rosa, Alessandra, Del Monte, Ettore, Di Gesu, Laura, Di Lalla, Niccolo, Donnarumma, Immacolata, Dovciak, Michal, Ehlert, Steven R., Enoto, Teruaki, Evangelista, Yuri, Fabiani, Sergio, Ferrazzoli, Riccardo, Garcia, Javier A., Gunji, Shuichi, Hayashida, Kiyoshi, Iwakiri, Wataru, Jorstad, Svetlana G., Karas, Vladimir, Kislat, Fabian, Kitaguchi, Takao, Kolodziejczak, Jeffery J., Latronico, Luca, Maldera, Simone, Manfreda, Alberto, Marin, Frederic, Marinucci, Andrea, Marscher, Alan P., Marshall, Herman L., Massaro, Francesco, Matt, Giorgio, Mitsuishi, Ikuyuki, Mizuno, Tsunefumi, Muleri, Fabio, Negro, Michela, Ng, Chi-Yung, O'Dell, Stephen L., Omodei, Nicola, Oppedisano, Chiara, Papitto, Alessandro, Peirson, Abel L., Perri, Matteo, Pesce-Rollins, Melissa, Petrucci, Pierre-Olivier, Pilia, Maura, Possenti, Andrea, Puccetti, Simonetta, Ramsey, Brian D., Rankin, John, Ratheesh, Ajay, Roberts, Oliver J., Romani, Roger W., Sgro, Carmelo, Slane, Patrick, Soffitta, Paolo, Spandre, Gloria, Swartz, Douglas A., Tamagawa, Toru, Tavecchio, Fabrizio, Taverna, Roberto, Tawara, Yuzuru, Tennant, Allyn F., Thomas, Nicholas E., Tombesi, Francesco, Trois, Alessio, Turolla, Roberto, Vink, Jacco, Wu, Kinwah, and Xie, Fei
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Solar and Stellar Astrophysics
Abstract: Discovery of pulsations from a number of ULXs proved that accretion onto neutron stars can produce luminosities exceeding the Eddington limit by several orders of magnitude. The conditions necessary to achieve such high luminosities as well as the exact geometry of the accretion flow in the neutron star vicinity are, however, a matter of debate. The pulse phase-resolved polarization measurements that became possible with the launch of the Imaging X-ray Polarimetry Explorer (IXPE) can be used to determine the pulsar geometry and its orientation relative to the orbital plane. They provide an avenue to test different theoretical models of ULX pulsars. In this paper we present the results of three IXPE observations of the first Galactic ULX pulsar Swift J0243.6+6124 during its 2023 outburst. We find strong variations in the polarization characteristics with the pulsar phase. The average polarization degree increases from about 5% to 15% as the flux dropped by a factor of three in the course of the outburst. The polarization angle (PA) as a function of the pulsar phase shows two peaks in the first two observations, but changes to a characteristic sawtooth pattern in the remaining data set. This is not consistent with a simple rotating vector model. Assuming the existence of an additional constant polarized component, we were able to fit the three observations with a common rotating vector model and obtain constraints on the pulsar geometry. In particular, we find the pulsar angular momentum inclination with respect to the line of sight of 15-40 deg, the magnetic obliquity of 60-80 deg, and the pulsar spin position angle of -50 deg, which significantly differs from the constant component PA of about 10 deg. Combining these X-ray measurements with the optical PA, we find evidence for at least a 30 deg misalignment between the pulsar angular momentum and the binary orbital axis., Comment: 13 pages, 10 figures, version published in A&A
Published: 2024
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29. Discovery of a shock-compressed magnetic field in the north-western rim of the young supernova remnant RX J1713.7-3946 with X-ray polarimetry

Author: Ferrazzoli, Riccardo, Prokhorov, Dmitry, Bucciantini, Niccolò, Slane, Patrick, Vink, Jacco, Cardillo, Martina, Yang, Yi-Jung, Silvestri, Stefano, Zhou, Ping, Costa, Enrico, Omodei, Nicola, Ng, C. -Y., Soffitta, Paolo, Weisskopf, Martin C., Baldini, Luca, Di Marco, Alessandro, Doroshenko, Victor, Heyl, Jeremy, Kaaret, Philip, Kim, Dawoon E., Marin, Frédéric, Mizuno, Tsunefumi, Pesce-Rollins, Melissa, Sgrò, Carmelo, Swartz, Douglas A., Tamagawa, Toru, Xie, Fei, Agudo, Iván, Antonelli, Lucio A., Bachetti, Matteo, Baumgartner, Wayne H., Bellazzini, Ronaldo, Bianchi, Stefano, Bongiorno, Stephen D., Bonino, Raffaella, Brez, Alessandro, Capitanio, Fiamma, Castellano, Simone, Cavazzuti, Elisabetta, Chen, Chien-Ting, Ciprini, Stefano, De Rosa, Alessandra, Del Monte, Ettore, Di Gesu, Laura, Di Lalla, Niccolò, Donnarumma, Immacolata, Dovčiak, Michal, Ehlert, Steven R., Enoto, Teruaki, Evangelista, Yuri, Fabiani, Sergio, Garcia, Javier A., Gunji, Shuichi, Hayashida, Kiyoshi, Iwakiri, Wataru, Jorstad, Svetlana G., Karas, Vladimir, Kislat, Fabian, Kitaguchi, Takao, Kolodziejczak, Jeffery J., Krawczynski, Henric, La Monaca, Fabio, Latronico, Luca, Liodakis, Ioannis, Maldera, Simone, Manfreda, Alberto, Marinucci, Andrea, Marscher, Alan P., Marshall, Herman L., Massaro, Francesco, Matt, Giorgio, Mitsuishi, Ikuyuki, Muleri, Fabio, Negro, Michela, O'Dell, Stephen L., Oppedisano, Chiara, Papitto, Alessandro, Pavlov, George G., Peirson, Abel L., Perri, Matteo, Petrucci, Pierre-Olivier, Pilia, Maura, Possenti, Andrea, Poutanen, Juri, Puccetti, Simonetta, Ramsey, Brian D., Rankin, John, Ratheesh, Ajay, Roberts, Oliver J., Romani, Roger W., Spandre, Gloria, Tavecchio, Fabrizio, Taverna, Roberto, Tawara, Yuzuru, Tennant, Allyn F., Thomas, Nicholas E., Tombesi, Francesco, Trois, Alessio, Tsygankov, Sergey S., Turolla, Roberto, Wu, Kinwah, and Zane, Silvia
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies
Abstract: Supernova remnants (SNRs) provide insights into cosmic-ray acceleration and magnetic field dynamics at shock fronts. Recent X-ray polarimetric measurements by the Imaging X-ray Polarimetry Explorer (IXPE) have revealed radial magnetic fields near particle acceleration sites in young SNRs, including Cassiopeia A, Tycho, and SN 1006. We present here the spatially-resolved IXPE X-ray polarimetric observation of the northwestern rim of SNR RX J1713.7-3946. For the first time, our analysis shows that the magnetic field in particle acceleration sites of this SNR is oriented tangentially with respect to the shock front. Because of the lack of precise Faraday-rotation measurements in the radio band, this was not possible before. The average measured polarization degree (PD) of the synchtrotron emission is 12.5 {\pm} 3.3%, lower than the one measured by IXPE in SN 1006, comparable to the Tycho one, but notably higher than the one in Cassiopeia A. On sub-parsec scales, localized patches within RX J1713.7-3946 display PD up to 41.5 {\pm} 9.5%. These results are compatible with a shock-compressed magnetic field. However, in order to explain the observed PD, either the presence of a radial net magnetic field upstream of the shock, or partial reisotropization of the turbulence downstream by radial magneto-hydrodynamical instabilities, can be invoked. From comparison of PD and magnetic field distribution with {\gamma}-rays and 12 CO data, our results provide new inputs in favor of a leptonic origin of the {\gamma}-ray emission., Comment: 18 pages, 6 figures, 2 tables, published in ApJ Letters
Published: 2024
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30. The Design, Implementation, and Performance of the LZ Calibration Systems

Author: Aalbers, J., Akerib, D. S., Musalhi, A. K. Al, Alder, F., Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Baker, A., Balashov, S., Bang, J., Barillier, E. E., Bargemann, J. W., Beattie, K., Benson, T., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Bishop, E., Blockinger, G. M., Boxer, B., Brew, C. A. J., Brás, P., Burdin, S., Buuck, M., Carmona-Benitez, M. C., Carter, M., Chawla, A., Chen, H., Cherwinka, J. J., Chin, Y. T., Chott, N. I., Converse, M. V., Cottle, A., Cox, G., Curran, D., Dahl, C. E., David, A., Delgaudio, J., Dey, S., de Viveiros, L., Di Felice, L., Ding, C., Dobson, J. E. Y., Druszkiewicz, E., Eriksen, S. R., Fan, A., Fearon, N. M., Fieldhouse, N., Fiorucci, S., Flaecher, H., Fraser, E. D., Fruth, T. M. A., Gaitskell, R. J., Geffre, A., Genovesi, J., Ghag, C., Gibbons, R., Gokhale, S., Green, J., van der Grinten, M. G. D., Haiston, J. J., Hall, C. R., Han, S., Hartigan-O'Connor, E., Haselschwardt, S. J., Hernandez, M. A., Hertel, S. A., Heuermann, G., Homenides, G. J., Horn, M., Huang, D. Q., Hunt, D., Jacquet, E., James, R. S., Johnson, J., Kaboth, A. C., Kamaha, A. C., Kannichankandy, M., Khaitan, D., Khazov, A., Khurana, I., Kim, J., Kim, Y. D., Kingston, J., Kirk, R., Kodroff, D., Korley, L., Korolkova, E. V., Kraus, H., Kravitz, S., Kreczko, L., Kudryavtsev, V. A., Leonard, D. S., Lesko, K. T., Levy, C., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Lopes, M. I., Lorenzon, W., Lu, C., Luitz, S., Majewski, P. A., Manalaysay, A., Mannino, R. L., Maupin, C., McCarthy, M. E., McDowell, G., McKinsey, D. N., McLaughlin, J., Mclaughlin, J. B., McMonigle, R., Miller, E. H., Mizrachi, E., Monte, A., Monzani, M. E., Mendoza, J. D. Morales, Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naylor, A., Nelson, H. N., Neves, F., Nguyen, A., Nikoleyczik, J. A., Olcina, I., Oliver-Mallory, K. C., Orpwood, J., Palladino, K. J., Palmer, J., Pannifer, N. J., Parveen, N., Patton, S. J., Penning, B., Pereira, G., Perry, E., Pershing, T., Piepke, A., Qie, Y., Reichenbacher, J., Rhyne, C. A., Riffard, Q., Rischbieter, G. R. C., Riyat, H. S., Rosero, R., Rushton, T., Rynders, D., Santone, D., Sazzad, A. B. M. R., Schnee, R. W., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Siniscalco, J., Smith, R., Solovov, V. N., Sorensen, P., Soria, J., Stancu, I., Stevens, A., Stifter, K., Suerfu, B., Sumner, T. J., Szydagis, M., Taylor, W. C., Tiedt, D. R., Timalsina, M., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Tronstad, D. R., Vacheret, A., Vaitkus, A. C., Valentino, O., Velan, V., Wang, A., Wang, J. J., Wang, Y., Watson, J. R., Webb, R. C., Weeldreyer, L., Whitis, T. J., Williams, M., Wisniewski, W. J., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Xia, Q., Xiang, X., Xu, J., and Yeh, M.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: LUX-ZEPLIN (LZ) is a tonne-scale experiment searching for direct dark matter interactions and other rare events. It is located at the Sanford Underground Research Facility (SURF) in Lead, South Dakota, USA. The core of the LZ detector is a dual-phase xenon time projection chamber (TPC), designed with the primary goal of detecting Weakly Interacting Massive Particles (WIMPs) via their induced low energy nuclear recoils. Surrounding the TPC, two veto detectors immersed in an ultra-pure water tank enable reducing background events to enhance the discovery potential. Intricate calibration systems are purposely designed to precisely understand the responses of these three detector volumes to various types of particle interactions and to demonstrate LZ's ability to discriminate between signals and backgrounds. In this paper, we present a comprehensive discussion of the key features, requirements, and performance of the LZ calibration systems, which play a crucial role in enabling LZ's WIMP-search and its broad science program. The thorough description of these calibration systems, with an emphasis on their novel aspects, is valuable for future calibration efforts in direct dark matter and other rare-event search experiments.
Published: 2024
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31. Constraints On Covariant WIMP-Nucleon Effective Field Theory Interactions from the First Science Run of the LUX-ZEPLIN Experiment

Author: Aalbers, J., Akerib, D. S., Musalhi, A. K. Al, Alder, F., Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Baker, A., Balashov, S., Bang, J., Barillier, E. E., Bargemann, J. W., Beattie, K., Benson, T., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Bishop, E. J., Blockinger, G. M., Boxer, B., Brew, C. A. J., Brás, P., Burdin, S., Buuck, M., Carmona-Benitez, M. C., Carter, M., Chawla, A., Chen, H., Cherwinka, J. J., Chin, Y. T., Chott, N. I., Converse, M. V., Cottle, A., Cox, G., Curran, D., Dahl, C. E., David, A., Delgaudio, J., Dey, S., de Viveiros, L., Di Felice, L., Ding, C., Dobson, J. E. Y., Druszkiewicz, E., Eriksen, S. R., Fan, A., Fearon, N. M., Fiorucci, S., Flaecher, H., Fraser, E. D., Fruth, T. M. A., Gaitskell, R. J., Geffre, A., Genovesi, J., Ghag, C., Gibbons, R., Gokhale, S., Green, J., van der Grinten, M. G. D., Haiston, J. H., Hall, C. R., Han, S., Hartigan-O'Connor, E., Haselschwardt, S. J., Hernandez, M. A., Hertel, S. A., Heuermann, G., Homenides, G. J., Horn, M., Huang, D. Q., Hunt, D., Ignarra, C. M., Jacquet, E., James, R. S., Johnson, J., Kaboth, A. C., Kamaha, A. C., Kannichankandy, M., Khaitan, D., Khazov, A., Khurana, I., Kim, J., Kingston, J., Kirk, R., Kodroff, D., Korley, L., Korolkova, E. V., Kraus, H., Kravitz, S., Kreczko, L., Kudryavtsev, V. A., Lee, J., Leonard, D. S., Lesko, K. T., Levy, C., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Lopes, M. I., Lorenzon, W., Lu, C., Luitz, S., Majewski, P. A., Manalaysay, A., Mannino, R. L., Maupin, C., McCarthy, M. E., McDowell, G., McKinsey, D. N., McLaughlin, J., McLaughlin, J. B., McMonigle, R., Miller, E. H., Mizrachi, E., Monte, A., Monzani, M. E., Mendoza, J. D. Morales, Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naylor, A., Nelson, H. N., Neves, F., Nguyen, A., Nikoleyczik, J. A., Olcina, I., Oliver-Mallory, K. C., Orpwood, J., Palladino, K. J., Palmer, J., Pannifer, N. J., Parveen, N., Patton, S. J., Penning, B., Pereira, G., Perry, E., Pershing, T., Piepke, A., Qie, Y., Reichenbacher, J., Rhyne, C. A., Riffard, Q., Rischbieter, G. R. C., Riyat, H. S., Rosero, R., Rushton, T., Rynders, D., Santone, D., Sazzad, A. B. M. R., Schnee, R. W., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Siniscalco, J., Smith, R., Solovov, V. N., Sorensen, P., Soria, J., Stancu, I., Stevens, A., Stifter, K., Suerfu, B., Sumner, T. J., Szydagis, M., Taylor, W. C., Tiedt, D. R., Timalsina, M., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Tronstad, D. R., Vacheret, A., Vaitkus, A. C., Valentino, O., Velan, V., Wang, A., Wang, J. J., Wang, Y., Watson, J. R., Webb, R. C., Weeldreyer, L., Whitis, T. J., Williams, M., Wisniewski, W. J., Wolfs, F. L. H., Woodford, S., Woodward, D., Wright, C. J., Xia, Q., Xiang, X., Xu, J., Yeh, M., and Zweig, E. A.
Subjects: High Energy Physics - Experiment
Abstract: The first science run of the LUX-ZEPLIN (LZ) experiment, a dual-phase xenon time project chamber operating in the Sanford Underground Research Facility in South Dakota, USA, has reported leading limits on spin-independent WIMP-nucleon interactions and interactions described from a non-relativistic effective field theory (NREFT). Using the same 5.5~t fiducial mass and 60 live days of exposure we report on the results of a relativistic extension to the NREFT. We present constraints on couplings from covariant interactions arising from the coupling of vector, axial currents, and electric dipole moments of the nucleon to the magnetic and electric dipole moments of the WIMP which cannot be described by recasting previous results described by an NREFT. Using a profile-likelihood ratio analysis, in an energy region between 0~keV$_\text{nr}$ to 270~keV$_\text{nr}$, we report 90% confidence level exclusion limits on the coupling strength of five interactions in both the isoscalar and isovector bases., Comment: 7 pages, 4 figures
Published: 2024

32. Numerical study of neutral and charged microgel suspensions: from single-particle to collective behavior

Author: Del Monte, Giovanni and Zaccarelli, Emanuela
Subjects: Condensed Matter - Soft Condensed Matter
Abstract: We perform extensive Molecular Dynamics simulations of an ensemble of realistic microgel particles in swollen conditions in a wide range of packing fractions $\zeta$. We compare neutral and charged microgels, where we consider charges distribution adherent to experimental conditions. Through a detailed analysis of single-particle behavior, we are able to identify the different regimes occurring upon increasing concentration: from shrinking to deformation and interpenetration, always connecting our findings to available experimental observations. We then link these single-particle features to the collective behavior of the suspension, finding evidence of a structural reentrance, that has no counterpart in the dynamics. Hence, while the maximum of the radial distribution function displays a non-monotonic behavior with increasing $\zeta$, the dynamics, quantified by the microgels' mean-squared displacement, always slows down. Key similarities and differences between neutral and charged microgels are identified. Importantly, at high enough $\zeta$ we also detect the fusion of the shells of charged microgels, that was previously invoked to explain key experimental findings. This highlights the fact that even for standard poly(N-isopropylacrylamide) microgels, commonly considered as a prototype of soft colloid, charge effects are relevant. Overall, our study establishes a powerful framework to uncover the physics of microgel suspensions under several different conditions. Indeed, it can be readily extended to tackle different regimes, e.g. high temperature, and systems, e.g. complex microgel topologies such as ultra-low-crosslinked ones, where experimental evidence is still limited.
Published: 2024

33. Theoretical and numerical comparison between the pseudopotential and the free energy lattice Boltzmann methods

Author: Czelusniak, L. E., Martins, I. T., Cabezas-Gómez, L., Bulgarelli, N. A. V., Verde, W. Monte, and de Castro, M. S.
Subjects: Physics - Computational Physics
Abstract: The pseudopotential and free energy models are two popular extensions of the lattice Boltzmann method for multiphase flows. Until now, they have been developed apart from each other in the literature. However, important questions about whether each method performs better needs to be solved. In this work, we perform a theoretical and numerical comparison between both methods. This comparison is only possible because we developed a novel approach for controlling the interface thickness in the pseudopotential method independently on the equation of state. In this way, it is possible to compare both methods maintaining the same equilibrium densities, interface thickness, surface tension and equation of state parameters. The well-balanced approach was selected to represent the free energy. We found that the free energy one is more practical to use, as it is not necessary to carry out previous simulations to determine simulation parameters (interface thickness, surface tension, etc). In addition, the tests proofed that the free energy model is more accurate than the pseudopotential model. Furthermore, the pseudopotential method suffers from a lack of thermodynamic consistency even when applying the corrections proposed in the literature. On the other hand, for both static and dynamic tests we verified that the pseudopotential method is more stable than the free energy one, allowing simulations with lower reduced temperatures. We hope that these results will guide authors in the use of each method., Comment: 20 pages, 9 figures
Published: 2024

34. A simple and accurate method to determine fluid-crystal phase boundaries from direct coexistence simulations

Author: Smallenburg, Frank, Del Monte, Giovanni, de Jager, Marjolein, and Filion, Laura
Subjects: Condensed Matter - Soft Condensed Matter, Condensed Matter - Statistical Mechanics
Abstract: One method for computationally determining phase boundaries is to explicitly simulate a direct coexistence between the two phases of interest. Although this approach works very well for fluid-fluid coexistences, it is often considered to be less useful for fluid-crystal transitions, as additional care must be taken to prevent the simulation boundaries from imposing unwanted strains on the crystal phase. Here, we present a simple adaptation to the direct coexistence method that nonetheless allows us to obtain highly accurate predictions of fluid-crystal coexistence conditions. We test our approach on hard spheres, the screened Coulomb potential, and a 2D patchy-particle model. In all cases, we find excellent agreement between the direct coexistence approach and (much more cumbersome) free-energy calculation methods. Moreover, the method is sufficiently accurate to resolve the (tiny) free-energy difference between the face-centered cubic and hexagonally close-packed crystal of hard spheres in the thermodynamic limit. The simplicity of this method also ensures that it can be trivially implemented in essentially any simulation method or package. Hence, this approach provides an excellent alternative to free-energy based methods for the precise determination of phase boundaries., Comment: Consists of a manuscript, SI, and sample LAMMPS script
Published: 2024

35. X-ray polarization measurement of the gold standard of radio-quiet active galactic nuclei : NGC 1068

Author: Marin, F., Marinucci, A., Laurenti, M., Kim, D. E., Barnouin, T., Di Marco, A., Ursini, F., Bianchi, S., Ravi, S., Marshall, H. L., Matt, G., Chen, C. -T., Gianolli, V. E., Ingram, A., Maksym, W. P., Panagiotou, C., Podgorny, J., Puccetti, S., Ratheesh, A., Tombesi, F., Agudo, I., Antonelli, L. A., Bachetti, M., Baldini, L., Baumgartner, W., Bellazzini, R., Bongiorno, S., Bonino, R., Brez, A., Bucciantini, N., Capitanio, F., Castellano, S., Cavazzuti, E., Ciprini, S., Costa, E., De Rosa, A., Del Monte, E., Di Gesu, L., Di Lalla, N., Donnarumma, I., Doroshenko, V., Dovciak, M., Ehlert, S., Enoto, T., Evangelista, Y., Fabiani, S., Ferrazzoli, R., Garcia, J., Gunji, S., Heyl, J., Iwakiri, W., Jorstad, S., Kaaret, P., Karas, V., Kislat, F., Kitaguchi, T., Kolodziejczak, J., Krawczynski, H., La Monaca, F., Latronico, L., Liodakis, I., Madejski, G., Maldera, S., Manfreda, A., Marscher, A., Massaro, F., Mitsuishi, I., Mizuno, T., Muleri, F., Negro, M., Ng, S., O'Dell, S., Omodei, N., Oppedisano, C., Papitto, A., Pavlov, G., Perri, M., Pesce-Rollins, M., Petrucci, P. -O., Pilia, M., Possenti, A., Poutanen, J., Ramsey, B., Rankin, J., Roberts, O., Romani, R., Sgro, C., Slane, P., Soffitta, P., Spandre, G., Swartz, D., Tamagawa, T., Tavecchio, F., Taverna, R., Tawara, Y., Tennant, A., Thomas, N., Trois, A., Tsygankov, S., Turolla, R., Vink, J., Weisskopf, M., Wu, K., Xie, F., and Zane, S.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies, J.2.3, J.2.9
Abstract: We used the Imaging X-ray Polarimetry Explorer (IXPE) satellite to measure, for the first time, the 2-8 keV polarization of NGC 1068. We pointed IXPE for a net exposure time of 1.15 Ms on the target, in addition to two ~ 10 ks each Chandra snapshots in order to account for the potential impact of several ultraluminous X-ray source (ULXs) within IXPE's field-of-view. We measured a 2 - 8 keV polarization degree of 12.4% +/- 3.6% and an electric vector polarization angle of 101{\deg} +/- 8{\deg} at 68% confidence level. If we exclude the spectral region containing the bright Fe K lines and other soft X-ray lines where depolarization occurs, the polarization fraction rises up to 21.3% +/- 6.7% in the 3.5 - 6.0 keV band, with a similar polarization angle. The observed polarization angle is found to be perpendicular to the parsec scale radio jet. Using a combined Chandra and IXPE analysis plus multi-wavelength constraints, we estimated that the circumnuclear "torus" may sustain a half-opening angle of 50{\deg} - 55{\deg} (from the vertical axis of the system). Thanks to IXPE, we have measured the X-ray polarization of NGC 1068 and found comparable results, both in terms of polarization angle orientation with respect to the radio-jet and torus half-opening angle, to the X-ray polarimetric measurement achieved for the other archetypal Compton-thick AGN : the Circinus galaxy. Probing the geometric arrangement of parsec-scale matter in extragalactic object is now feasible thanks to X-ray polarimetry., Comment: 9 pages, 5 figures, 2 tables, submited to A&A
Published: 2024
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36. CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

Author: Skoulidis, Ferdinandos, Araujo, Haniel A., Do, Minh Truong, Qian, Yu, Sun, Xin, Cobo, Ana Galan, Le, John T., Montesion, Meagan, Palmer, Rachael, Jahchan, Nadine, Juan, Joseph M., Min, Chengyin, Yu, Yi, Pan, Xuewen, Arbour, Kathryn C., Vokes, Natalie, Schmidt, Stephanie T., Molkentine, David, Owen, Dwight H., Memmott, Regan, Patil, Pradnya D., Marmarelis, Melina E., Awad, Mark M., Murray, Joseph C., Hellyer, Jessica A., Gainor, Justin F., Dimou, Anastasios, Bestvina, Christine M., Shu, Catherine A., Riess, Jonathan W., Blakely, Collin M., Pecot, Chad V., Mezquita, Laura, Tabbó, Fabrizio, Scheffler, Matthias, Digumarthy, Subba, Mooradian, Meghan J., Sacher, Adrian G., Lau, Sally C. M., Saltos, Andreas N., Rotow, Julia, Johnson, Rocio Perez, Liu, Corinne, Stewart, Tyler, Goldberg, Sarah B., Killam, Jonathan, Walther, Zenta, Schalper, Kurt, Davies, Kurtis D., Woodcock, Mark G., Anagnostou, Valsamo, Marrone, Kristen A., Forde, Patrick M., Ricciuti, Biagio, Venkatraman, Deepti, Van Allen, Eliezer M., Cummings, Amy L., Goldman, Jonathan W., Shaish, Hiram, Kier, Melanie, Katz, Sharyn, Aggarwal, Charu, Ni, Ying, Azok, Joseph T., Segal, Jeremy, Ritterhouse, Lauren, Neal, Joel W., Lacroix, Ludovic, Elamin, Yasir Y., Negrao, Marcelo V., Le, Xiuning, Lam, Vincent K., Lewis, Whitney E., Kemp, Haley N., Carter, Brett, Roth, Jack A., Swisher, Stephen, Lee, Richard, Zhou, Teng, Poteete, Alissa, Kong, Yifan, Takehara, Tomohiro, Paula, Alvaro Guimaraes, Parra Cuentas, Edwin R., Behrens, Carmen, Wistuba, Ignacio I., Zhang, Jianjun, Blumenschein, George R., Gay, Carl, Byers, Lauren A., Gibbons, Don L., Tsao, Anne, Lee, J. Jack, Bivona, Trever G., Camidge, D. Ross, Gray, Jhannelle E., Lieghl, Natasha, Levy, Benjamin, Brahmer, Julie R., Garassino, Marina C., Gandara, David R., Garon, Edward B., Rizvi, Naiyer A., Scagliotti, Giorgio Vittorio, Wolf, Jürgen, Planchard, David, Besse, Benjamin, Herbst, Roy S., Wakelee, Heather A., Pennell, Nathan A., Shaw, Alice T., Jänne, Pasi A., Carbone, David P., Hellmann, Matthew D., Rudin, Charles M., Albacker, Lee, Mann, Helen, Zhu, Zhou, Lai, Zhongwu, Stewart, Ross, Peters, Solange, Johnson, Melissa L., Wong, Kwok K., Huang, Alan, Winslow, Monte M., Rosen, Michael J., Winters, Ian P., Papadimitrakopoulou, Vassiliki A., Cascone, Tina, Jewsbury, Philip, and Heymach, John V.
Published: 2024
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37. Engaging with the Problem (and Misframing) of Teacher Wellbeing in Aotearoa New Zealand: Notes for Context-Based Social Justice Approaches

Author: Del Monte, Pablo and Kamenarac, Olivera
Published: 2024
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38. High levels of glycated haemoglobin (HbA1c) are associated with lower knee joint cartilage quality and higher knee joint symptoms in healthy individuals

Author: Monte, Andrea, Vilimek, Dominik, Uchytil, Jaroslav, Skypala, Jiri, Cipryan, Lukáš, Casula, Victor, Jandačka, Daniel, and Nieminen, Miika T.
Published: 2024
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39. Repetitive Transcranial Magnetic Stimulation with Body Weight-supported Treadmill Training Enhances Independent Walking of Individuals with Chronic Incomplete Spinal Cord Injury: A Pilot Randomized Clinical Trial

Author: Nogueira, Fernanda, Shirahige, Lívia, Brito, Rodrigo, Lima, Hamably, Victor, João, Sanchez, María Paz, Ilha, Jocemar, and Monte-Silva, Katia
Published: 2024
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40. Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis

Author: Esplin, Edward D., Hanson, Casey, Wu, Si, Horning, Aaron M., Barapour, Nasim, Nevins, Stephanie A., Jiang, Lihua, Contrepois, Kévin, Lee, Hayan, Guha, Tuhin K., Hu, Zheng, Laquindanum, Rozelle, Mills, Meredith A., Chaib, Hassan, Chiu, Roxanne, Jian, Ruiqi, Chan, Joanne, Ellenberger, Mathew, Becker, Winston R., Bahmani, Bahareh, Khan, Aziz, Michael, Basil, Weimer, Annika K., Esplin, D. Glen, Shen, Jeanne, Lancaster, Samuel, Monte, Emma, Karathanos, Thomas V., Ladabaum, Uri, Longacre, Teri A., Kundaje, Anshul, Curtis, Christina, Greenleaf, William J., Ford, James M., and Snyder, Michael P.
Published: 2024
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41. Global loss of promoter–enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis

Author: Zhu, Yizhou, Lee, Hayan, White, Shannon, Weimer, Annika K., Monte, Emma, Horning, Aaron, Nevins, Stephanie A., Esplin, Edward D., Paul, Kristina, Krieger, Gat, Shipony, Zohar, Chiu, Roxanne, Laquindanum, Rozelle, Karathanos, Thomas V., Chua, Melissa W. Y., Mills, Meredith, Ladabaum, Uri, Longacre, Teri, Shen, Jeanne, Jaimovich, Ariel, Lipson, Doron, Kundaje, Anshul, Greenleaf, William J., Curtis, Christina, Ford, James M., and Snyder, Michael P.
Published: 2024
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42. Differential Effects of Cerebellar Transcranial Direct Current Stimulation with Gait Training on Functional Mobility, Balance, and Ataxia Symptoms

Author: Brito, Rodrigo, Fabrício, João Victor, Araujo, Aurine, Sacchi, Mariana, Baltar, Adriana, Lima, Fernanda Albuquerque, Ribeiro, Ana Cecília, Sousa, Bárbara, Santos, Camilla, Tanaka, Clarice, and Monte-Silva, Kátia
Published: 2024
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43. Single-Session Cerebellar Transcranial Direct Current Stimulation Improves Postural Stability and Reduces Ataxia Symptoms in Spinocerebellar Ataxia

Author: Brito, Rodrigo, Fabrício, João Victor, Araujo, Aurine, Barreto, Gabriel, Baltar, Adriana, and Monte-Silva, Kátia
Published: 2024
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44. Anti-Acanthamoeba metallopharmaceuticals: Amoebicidal activity and synergistic effect of copper(II) coordination compound

Author: da Silveira, Jaqueline, Cardoso, Ana Paula, Fernandes, Christiane, Junior, Adolfo Horn, da Rosa Monte Machado, Gabriella, and Caumo, Karin Silva
Published: 2024
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45. Development of O/W Pickering Emulsions Stabilized with Leek Leaf Trimmings Using Batch and Continuous Modes

Author: Marques, M. P., Sanchez-Salvador, J. L., Monte, M. C., Blanco, A., Santos, R. J., Dias, M. M., Manrique, Y. A., and Brito, M. S. C. A.
Published: 2024
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46. Risk Assessment as a Tool to Improve Water Resource Management

Author: Chernysh, Yelizaveta, Stejskalová, Lada, Soldán, Přemysl, Lai, Foon Yin, Khan, Uzair Akbar, Lundborg, Cecilia Stålsby, Giambérini, Laure, Minguez, Laetitia, Monte, M. Concepción, Blanco, Angeles, Skydanenko, Maksym, and Roubík, Hynek
Published: 2024
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47. Effects of minute oscillation stretching training on muscle and tendon stiffness and walking capability in people with type 2 diabetes

Author: Magris, Riccardo, Monte, Andrea, Nardello, Francesca, Trinchi, Michele, Vigolo, Nicolò, Negri, Carlo, Moghetti, Paolo, and Zamparo, Paola
Published: 2024
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48. Alterations in pharmacogenetic genes and their implications for imatinib resistance in Chronic Myeloid Leukemia patients from an admixed population

Author: Cereja-Pantoja, Karla Beatriz Cardias, de Brito Azevedo, Tereza Cristina, Vinagre, Lui Wallacy Morikawa Souza, de Moraes, Francisco Cezar Aquino, da Costa Nunes, Giovanna Gilioli, Monte, Natasha, de Alcântara, Angélica Leite, Cohen-Paes, Amanda, Fernandes, Marianne Rodrigues, Batista dos Santos, Sidney Emanuel, de Assumpção, Paulo Pimentel, Ribeiro dos Santos, Ândrea Kely, Burbano, Rommel Mario Rodríguez, Guerrero, Raquel Cruz, Carracedo, Ángel, and Carneiro dos Santos, Ney Pereira
Published: 2024
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49. Enhancing the epidemiological surveillance of SARS-CoV-2 using Sanger sequencing to identify circulating variants and recombinants

Author: Silva, Thaís, Oliveira, Eneida, Oliveira, Alana, Menezes, André, Jeremias, Wander de Jesus, Grenfell, Rafaella FQ, Monte-Neto, Rubens Lima do, Pascoal-Xavier, Marcelo A., Campos, Marco A., Fernandes, Gabriel, and Alves, Pedro
Published: 2024
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50. Microvesicle delivery of a lysosomal transport protein to ex vivo rabbit cornea

Author: Jess G. Thoene, Monte A. DelMonte, and Jodi Mullet
Subjects: Cystinosin, Microvesicles, Cornea, Rabbit, Therapy, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract: Therapeutic use of transmembrane proteins is limited because of irreversible denaturation when away from their native lipid membrane. Mutations in lysosomal membrane transport proteins cause many lethal disorders including cystinosis which results from mutations in CTNS, which codes for the lysosomal cystine transport protein, cystinosin. Cystinosin-deficient fibroblasts, including keratocytes (corneal fibroblasts) accumulate lysosomal cystine. Cystinosis patients develop highly painful corneal cystine crystals, resulting in severe visually debilitating photophobia. The only available therapy is daily treatment with cysteamine eye drops. We have previously shown that microvesicles containing functional cystinosin are spontaneously produced by infecting Spodoptera frugiperda cells (Sf9) with baculovirus containing human wt CTNS. Infecting Sf9 cells for 3 days at a MOI of 1 yields 1011microvesicles /ml with a modal diameter of 90 nm. Addition of these vesicles to cultures of cystinotic fibroblasts produces cystine depletion over the course of 96 h, which persists for 2 weeks. In this paper we show that addition of such microvesicles containing cystinosinGFP to ex vivo rabbit ocular globes yields punctate perinuclear green fluorescence in the corneal keratocytes. These results support potential therapeutic use of these cystinosin containing microvesicles in treating cystinotic corneal keratopathy with the advantage of administering twice/month instead of daily topical administration.
Published: 2020
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