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27 results on '"Montalto, Shana"'

1. Favorable outcome of SARS-CoV-2 infection in pediatric hematology oncology patients during the second and third pandemic waves in Italy: a multicenter analysis from the Infectious Diseases Working Group of the Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP)

Author

Zama, Daniele, Baccelli, Francesco, Colombini, Antonella, Contino, Amalia, Calore, Elisabetta, Petris, Maria Grazia, Meneghello, Linda, Mercolini, Federico, Lo Vecchio, Andrea, Montalto, Shana, Meazza, Cristina, Barone, Angelica, Compagno, Francesca, Muggeo, Paola, Soncini, Elena, Brescia, Letizia, Giraldi, Eugenia, Giurici, Nagua, Mura, Rosa Maria, Cellini, Monica, Perruccio, Katia, Petroni, Valeria, La Spina, Milena, Ziino, Ottavio, Burnelli, Roberta, De Santis, Raffaella, Mascarin, Maurizio, Barretta, Valentina, Tridello, Gloria, and Cesaro, Simone

Published
2022
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11. SARS-CoV-2 Infection in the Pediatric Oncology Population: The Definitive Comprehensive Report of the Infectious Diseases Working Group of AIEOP.

Author

Zama, Daniele, Zanaroli, Andrea, Corbelli, Agnese, Vecchio, Andrea Lo, Bene, Margherita Del, Colombini, Antonella, Compagno, Francesca, Barone, Angelica, Fontanili, Ilaria, D'Amico, Maria Rosaria, Papa, Maria Rosaria, Petris, Maria Grazia, Calore, Elisabetta, Montalto, Shana, Meneghello, Linda, Brescia, Letizia, Mura, Rosamaria, Spina, Milena La, Muggeo, Paola, and Rinieri, Simona

Subjects
PEDIATRIC oncology, COMMUNICABLE diseases, HEMATOPOIETIC stem cell transplantation, REPORTING of diseases, SARS-CoV-2
Abstract

Objective The objective of this study was to assess the clinical impact and outcome of the SARS-CoV-2 infection on children with cancer or those who received a hematopoietic stem cell transplantation. Methods AIEOP (Italian Association of Pediatric Hematology and Oncology) performed a nationwide multicenter observational cohort study, including consecutive patients between April 2020 and November 2022. Results Twenty-five Italian centers participated and 455 patients were enrolled. We reported a significant increasing trend of symptomatic cases over the years, while the number of nonmild infections remained stable. Early infection after oncologic diagnosis (<60 days) and severe neutropenia were identified as independent risk factors for developing moderate, severe, or critical infections. The percentage of patients who were asymptomatic and mildly symptomatic and who stopped chemotherapy reduced over the years of the pandemic. Nine patients died, but no death was attributed to SARS-CoV-2 infection. Conclusions SARS-CoV-2 infection presented a self-limiting benign course in the Italian pediatric oncohematology population during the pandemic, and its main consequence has been the discontinuation of cancer-directed therapies. The rate of patients who were asymptomatic and stopped chemotherapy reduced over the years, suggesting that the continuation of chemotherapy is a feasible option. [ABSTRACT FROM AUTHOR]

Published
2024
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12. The SARS-CoV-2 infection in the pediatric oncology population: the definitive comprehensive report of Infectious Diseases Working Group (IDWG) of AIEOP

Author

Zama, Daniele, primary, Zanaroli, Andrea, additional, Corbelli, Agnese, additional, Lo Vecchio, Andrea, additional, Del Bene, Margherita, additional, Colombini, Antonella, additional, Compagno, Francesca, additional, Barone, Angelica, additional, Fontanili, Ilaria, additional, D’Amico, Maria Rosaria, additional, Papa, Maria Rosaria, additional, Petris, Maria Grazia, additional, Calore, Elisabetta, additional, Montalto, Shana, additional, Meneghello, Linda, additional, Brescia, Letizia, additional, Mura, Rosamaria, additional, La Spina, Milena, additional, Muggeo, Paola, additional, Rinieri, Simona, additional, Meazza, Cristina, additional, Perruccio, Katia, additional, Cellini, Monica, additional, Spadea, Manuela, additional, Mercolini, Federico, additional, Petroni, Valeria, additional, De Santis, Raffaella, additional, Soncini, Elena, additional, Provenzi, Massimo, additional, Giurici, Nagua, additional, Ziino, Ottavio, additional, Tridello, Gloria, additional, and Cesaro, Simone, additional

Published
2023
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21. 1320. Incidence and Outcome of Gram Negative Blood Stream Infections in Pediatric Intensive Care Unit: a Real Life Experience in a Pediatric Hospital in Italy

Author

Labate, Laura, primary, Valentino, Maria Sole, additional, Bigatti, Carolina, additional, Medici, Chiara, additional, Palmero, Candida, additional, Losurdo, Giuseppe, additional, Cristina, Emilio, additional, Mariani, Marcello, additional, Ugolotti, Elisabetta, additional, Franceschi, Alessia, additional, Russo, Chiara, additional, Tavella, Elisa, additional, Bondi, Elisabetta, additional, Montalto, Shana, additional, Ricci, Erica, additional, Moscatelli, Andrea, additional, Castagnola, Elio, additional, and Mesini, Alessio, additional

Published
2022
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22. 144. Gram Negative Bacteria with Increased Minimal Inhibitory Concentration for Cefiderocol among Pediatric Patients in a Northern Italy Hospital.

Author

Russo, Chiara, primary, Sette, Claudia, additional, Medici, Chiara, additional, Losurdo, Giuseppe, additional, Palmero, Candida, additional, Saffioti, Carolina, additional, Mariani, Marcello, additional, Ricci, Erica, additional, Ugolotti, Elisabetta, additional, Bondi, Elisabetta, additional, Montalto, Shana, additional, Tavella, Elisa, additional, Castagnola, Elio, additional, and Mesini, Alessio, additional

Published
2022
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24. Case Report: Deficiency of Adenosine Deaminase 2 Presenting With Overlapping Features of Autoimmune Lymphoproliferative Syndrome and Bone Marrow Failure

Author

Dell’Orso, Gianluca, primary, Grossi, Alice, additional, Penco, Federica, additional, Caorsi, Roberta, additional, Palmisani, Elena, additional, Terranova, Paola, additional, Schena, Francesca, additional, Lupia, Michela, additional, Ricci, Erica, additional, Montalto, Shana, additional, Pierri, Filomena, additional, Ceccherini, Isabella, additional, Fioredda, Francesca, additional, Dufour, Carlo, additional, Gattorno, Marco, additional, and Miano, Maurizio, additional

Published
2021
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26. Case Report: Deficiency of Adenosine Deaminase 2 Presenting With Overlapping Features of Autoimmune Lymphoproliferative Syndrome and Bone Marrow Failure.

Author

Dell'Orso, Gianluca, Grossi, Alice, Penco, Federica, Caorsi, Roberta, Palmisani, Elena, Terranova, Paola, Schena, Francesca, Lupia, Michela, Ricci, Erica, Montalto, Shana, Pierri, Filomena, Ceccherini, Isabella, Fioredda, Francesca, Dufour, Carlo, Gattorno, Marco, and Miano, Maurizio

Subjects
LYMPHOPROLIFERATIVE disorders, ADENOSINE deaminase, BONE marrow, IDIOPATHIC thrombocytopenic purpura, HEMATOPOIETIC stem cell transplantation, GENETIC variation, PULMONARY embolism
Abstract

Deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive disease associated with a highly variable clinical presentation, such as vasculitis, inflammation, and hematologic manifestations. Some associations of clinical features can mimic autoimmune lymphoproliferative syndrome (ALPS). We report a case of a female patient who fulfilled the 2009 National Institute of Health revised criteria for ALPS and received a delayed diagnosis of DADA2. During her childhood, she suffered from autoimmune hemolytic anemia, immune thrombocytopenia, and chronic lymphoproliferation, which partially responded to multiple lines of treatments and were followed, at 25 years of age, by pulmonary embolism, septic shock, and bone marrow failure with myelodysplastic evolution. The patient died from the progression of pulmonary disease and multiorgan failure. Two previously unreported variants of gene ADA2/CECR1 were found through next-generation sequencing analysis, and a pathogenic role was demonstrated through a functional study. A single somatic STAT3 mutation was also found. Clinical phenotypes encompassing immune dysregulation and marrow failure should be evaluated at the early stage of diagnostic work-up with an extended molecular evaluation. A correct genetic diagnosis may lead to a precision medicine approach consisting of the use of targeted treatments or early hematopoietic stem cell transplantation. [ABSTRACT FROM AUTHOR]

Published
2021
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27. Favorable outcome of SARS-CoV-2 infection in pediatric hematology oncology patients during the second and third pandemic waves in Italy: a multicenter analysis from the Infectious Diseases Working Group of the Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP)

Author

Daniele Zama, Francesco Baccelli, Antonella Colombini, Amalia Contino, Elisabetta Calore, Maria Grazia Petris, Linda Meneghello, Federico Mercolini, Andrea Lo Vecchio, Shana Montalto, Cristina Meazza, Angelica Barone, Francesca Compagno, Paola Muggeo, Elena Soncini, Letizia Brescia, Eugenia Giraldi, Nagua Giurici, Rosa Maria Mura, Monica Cellini, Katia Perruccio, Valeria Petroni, Milena La Spina, Ottavio Ziino, Roberta Burnelli, Raffaella De Santis, Maurizio Mascarin, Valentina Barretta, Gloria Tridello, Simone Cesaro, Zama, Daniele, Baccelli, Francesco, Colombini, Antonella, Contino, Amalia, Calore, Elisabetta, Petris, Maria Grazia, Meneghello, Linda, Mercolini, Federico, Lo Vecchio, Andrea, Montalto, Shana, Meazza, Cristina, Barone, Angelica, Compagno, Francesca, Muggeo, Paola, Soncini, Elena, Brescia, Letizia, Giraldi, Eugenia, Giurici, Nagua, Mura, Rosa Maria, Cellini, Monica, Perruccio, Katia, Petroni, Valeria, La Spina, Milena, Ziino, Ottavio, Burnelli, Roberta, De Santis, Raffaella, Mascarin, Maurizio, Barretta, Valentina, Tridello, Gloria, and Cesaro, Simone

Subjects
SARS-COV- 2 infection, SARS-CoV-2, COVID-19, Pediatric oncology, General Medicine, Hematology, Communicable Diseases, Italy, Neoplasms, Humans, RNA, Viral, Child, Children, Pandemics, Outcome
Abstract

COVID-19 has a mild clinical course with low mortality rate in general pediatric population, while variable outcomes have been described in children with cancer. Infectious diseases working party of the AIEOP collected data on the clinical characteristics and outcomes of SARS-CoV-2 infections in pediatric oncology/hematology patients from April 2020 to May 2021, including the second and the third waves of the pandemic in Italy. Factors potentially associated with moderate, severe, or critical COVID-19 were analyzed. Of the 153 SARS-Cov2 infections recorded, 100 were asymptomatic and 53 symptomatic. The course of COVID-19 was mild in 41, moderate in 2, severe in 5, and critical in 5 children. A total of 40.5% of patients were hospitalized, ten requiring oxygen support and 5 admitted to the intensive care unit. Antibiotics and steroids were the most used therapies. No patient died due to SARS-CoV-2 infection. Infections occurring early ( 60 days) or during maintenance therapy. In the patients on active chemotherapy, 59% withdrew the treatment for a median of 15 days. SARS-CoV-2 presented a favorable outcome in children with cancer in Italy during the pandemic. Modification of therapy represents a major concern in this population. Our findings suggest considering regular chemotherapy continuation, particularly in patients on maintenance therapy or infected late after the diagnosis.

Published
2022

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