1,408 results on '"Montalescot, G."'
Search Results
2. Clinical characteristics and outcomes of COMPASS eligible patients in France. An analysis from the REACH Registry
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Darmon, A., Elbez, Y., Bhatt, D.L., Abtan, J., Mas, J.L., Cacoub, P., Montalescot, G., Billaut-Laden, I., Ducrocq, G., and Steg, P.G.
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- 2020
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3. Routine CYP2C19 Genotyping to Adjust Thienopyridine Treatment After Primary PCI for STEMI: Results of the GIANT Study
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Chevalier, Bernard, Montalescot, Gilles, Hulot, Jean-Sébastien, Belle, Loïc, Cayla, Guillaume, Le Breton, Hervé, Teiger, Emmanuel, Dambrin, Grégoire, Khalife, K., Schmutz, L., Funck, F., Berthier, R., Piot, C., Hannebicque, G., Montalescot, G., Lognone, T., De Poli, F., Chevalier, B., Lhoest, N., Schneeberger, M., Delarche, N., Faure, A., Aelion, H., Godin, M., Gilard, M., Ritz, B., Barraud, P., Barnay, P., Saïdi, L.N., Le Dref, O., Garot, P., Range, G., Georges, J., Robin, C., Cottin, Y., Belle, L., Souteyrand, G., Lafont, A., Fournier, A., Dupouy, P., Shayne, J., Chapon, P., Boureux, C., Faure, J.P., Ben Amer, H., Furber, A., Ormezzano, O., Bayet, G., Karrillon, G., Maillard, L., Grenzinger, A., Avran, A., Koning, R., Dumant, D., Lamit, X., Dauphin, R., Drogoul, L., Cuisset, T., Wittenberg, O., Peyre, J.P., Laury, P., Robert, R., Belle, Loic, Khalife, Khalife, Funck, François, Berthier, Romain, Piot, Christophe, and Tafflet, Muriel
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- 2020
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4. Prevalence and outcomes of left atrial appendage closure procedures with indication abiding or not to current French guidelines consensus
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Srour, A., primary, Guedeney, P., additional, Zeitouni, M., additional, Procopi, N., additional, Charleux, P., additional, Chevrot, G., additional, Hammoudi, N., additional, Collet, J.-P., additional, Silvain, J., additional, and Montalescot, G., additional
- Published
- 2024
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5. Phenotyping Coronary Plaque by Computed Tomography in Premature Coronary Artery Disease
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Rahoual, G., primary, Zeitouni, M., additional, Charpentier, E., additional, Ritvo, P.-G., additional, Rouanet, S., additional, Procopi, N., additional, Boukhelifa, S., additional, Charleux, P., additional, Guedeney, P., additional, Kerneis, M., additional, Barthelemy, O., additional, Silvain, J., additional, Montalescot, G., additional, Redheuil, A., additional, and Collet, J.-P., additional
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- 2024
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6. Characteristics, risk factors and outcomes of patients managed for left-sided infective endocarditis: A prospective study in a high-volume center
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Granger, C., primary, Mertens, E., additional, Bouziri, N., additional, Elegamandji, B., additional, Mihoubi, K., additional, Guedeney, P., additional, Lebreton, G., additional, Demondion, P., additional, Bleibtreu, A., additional, Collet, J.-P., additional, Montalescot, G., additional, Hekimian, G., additional, and Hammoudi, N., additional
- Published
- 2024
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7. Incidence and prediction of periprocedural myocardial infarction in elective PCI: The ALPHEUS-MI sub-study
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Montalescot, G., primary, Georges, J.-L., additional, Bellemain-Appaix, A., additional, Hauguel-Moreau, M., additional, Le Breton, H., additional, Saint-Etienne, C., additional, Caussin, C., additional, Monségu, J., additional, Cayla, G., additional, Beygui, F., additional, Rangé, G., additional, Motovska, Z., additional, Portal, J.-J., additional, Vicaut, E., additional, and Silvain, J., additional
- Published
- 2024
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8. Appropriate ischemic criteria for type 4a myocardial infarction: Insights from the ALPHEUS trial
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Roule, V., primary, Zeitouni, M., additional, Guedeney, P., additional, Beygui, F., additional, El Kasty, M., additional, Braïk, N., additional, Rangé, G., additional, Motovska, Z., additional, Cayla, G., additional, Vicaut, E., additional, Montalescot, G., additional, and Silvain, J., additional
- Published
- 2024
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9. P2Y12 inhibitor loading time before elective PCI and the prevention of myocardial necrosis
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Roule, V., primary, Beygui, F., additional, Cayla, G., additional, Rangé, G., additional, Motovska, Z., additional, Delarche, N., additional, Jourda, F., additional, Goube, P., additional, Guedeney, P., additional, Zeitouni, M., additional, El Kasty, M., additional, Laredo, M., additional, Vicaut, E., additional, Montalescot, G., additional, and Silvain, J., additional
- Published
- 2024
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10. Ticagrelor or Clopidogrel to reduce ischemic events after Percutaneous Coronary Intervention in chronic coronary syndrome in clopidogrel naive patient: The ALPHEUS Naive sub-study
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Manzo-Silberman, S., primary, Cayla, G., additional, Rangé, G., additional, Motovska, Z., additional, Vicaut, E., additional, Collet, J.-P., additional, Guedeney, P., additional, El Kasty, M., additional, Kerneis, M., additional, Zeitouni, M., additional, Filippi, E., additional, Coste, P., additional, Montalescot, G., additional, and Silvain, J., additional
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- 2024
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11. Exercise-induced pulmonary congestion is a promising marker to diagnose early stage heart failure in patients referred to rule out myocardial ischemia
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Granger, C., primary, Wallet, T., additional, Legrand, L., additional, Allali, Y., additional, Guedeney, P., additional, Isnard, R., additional, Pousset, F., additional, Lefeuvre, C., additional, Berman, E., additional, Helft, G., additional, Collet, J.-P., additional, Montalescot, G., additional, and Hammoudi, N., additional
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- 2024
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12. Ticagrelor versus clopidogrel for complex percutaneous coronary intervention in chronic coronary syndrome: A post-hoc analysis of the ALPHEUS study
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Lattuca, B., primary, Mazeau, C., additional, Cayla, G., additional, Ducrocq, G., additional, Guedeney, P., additional, Kala, P., additional, Nejjari, M., additional, Morel, O., additional, Leclercq, F., additional, Payot, L., additional, Beygui, F., additional, Rangé, G., additional, Motovska, Z., additional, Vicaut, E., additional, Collet, J.-P., additional, Montalescot, G., additional, and Silvain, J., additional
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- 2024
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13. Prise en charge de la maladie coronaire chronique : vers de nouvelles recommandations ?: Management of chronic coronary artery disease: are new guidelines warranted?
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Guedeney, P. and Montalescot, G.
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- 2019
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14. Exercise-induced pulmonary congestion is a promising marker to diagnose early stage heart failure in patients referred to rule out myocardial ischemia
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Granger, C, primary, Legrand, L, additional, Allali, Y, additional, Wallet, T, additional, Guedeney, P, additional, Pousset, F, additional, Berman, E, additional, Helft, G, additional, Le Feuvre, C, additional, Isnard, R, additional, Collet, J P, additional, Montalescot, G, additional, and Hammoudi, N, additional
- Published
- 2023
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15. Ticagrelor versus clopidogrel for complex percutaneous coronary intervention in chronic coronary syndrome: a post-hoc analysis of the ALPHEUS study
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Lattuca, B, primary, Mazeau, C, additional, Guedeney, P, additional, Kala, P, additional, Nejjari, M, additional, Morel, O, additional, Leclercq, F, additional, Payot, L, additional, Beygui, F, additional, Range, G, additional, Motovska, Z, additional, Vicaut, E, additional, Collet, J P, additional, Montalescot, G, additional, and Silvain, J, additional
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- 2023
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16. Incidence and determinants of non-radial vascular approach for coronary angiography among heart transplant recipients
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Procopi, N, primary, Guedeney, P, additional, Zeitouni, M, additional, Kerneis, M, additional, Barthelemy, O, additional, Le Feuvre, C, additional, Silvain, J, additional, Berman, E, additional, Coutance, G, additional, Varnous, S, additional, Leprince, P, additional, Lebreton, G, additional, Collet, J P, additional, Montalescot, G, additional, and Helft, G, additional
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- 2023
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17. Impact of transfusion on platelet aggregation and biomarkers in myocardial infarction patients with anemia: an ancillary study of the randomized REALITY trial
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Silvain, J, primary, Lattuca, B, additional, Puymirat, E, additional, Ducrocq, G, additional, Dillinger, J G, additional, Lhermusier, T, additional, Cachanado, M, additional, Drouet, E, additional, Abergel, H, additional, Danchin, N, additional, Montalescot, G, additional, Simon, T, additional, and Steg, P G, additional
- Published
- 2023
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18. Ticagrelor or Clopidogrel to reduce ischemic events after Percutaneous Coronary Intervention in chronic coronary syndrome in clopidogrel naive patient: the ALPHEUS Naive sub-study
- Author
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Manzo-Silberman, S, primary, Cayla, G, additional, Beygui, F, additional, Range, G, additional, Motovska, Z, additional, Vicaut, E, additional, Collet, J P, additional, Guedeney, P, additional, El Kasty, M, additional, Kerneis, M, additional, Zeitouni, M, additional, Filippi, E, additional, Coste, P, additional, Montalescot, G, additional, and Silvain, J, additional
- Published
- 2023
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19. Microtransesophageal echocardiographic guidance of patent foramen ovale percutaneous closure
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Bouziri, N, primary, Guedeney, P, additional, Malvy, J, additional, Zeitouni, M, additional, Mertens, E, additional, Ceccaldi, A, additional, Wallet, T, additional, Djebbar, R, additional, Silvain, J, additional, Montalescot, G, additional, and Hammoudi, N, additional
- Published
- 2023
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20. Incidence and prediction of periprocedural myocardial infarction in elective PCI: the ALPHEUS-MI sub-study
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Montalescot, G, primary, Georges, J L, additional, Bellemain-Appaix, A, additional, Hauguel-Moreau, M, additional, Le Breton, H, additional, Saint-Etienne, C, additional, Caussin, C, additional, Montsegu, J, additional, Cayla, G, additional, Beygui, F, additional, Range, G, additional, Motovska, Z, additional, Portal, J J, additional, Vicaut, E, additional, and Silvain, J, additional
- Published
- 2023
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21. Detection of cardiac arrhythmias following acute coronary syndrome using a connected continuous rhythm monitoring device
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Charleux, P, primary, Zeitouni, M, additional, Procopi, N, additional, Devos, P, additional, Barthelemy, O, additional, Guedeney, P, additional, Granger, C, additional, Ferrante, A, additional, Laredo, M, additional, Kerneis, M, additional, Silvain, J, additional, Collet, J P, additional, and Montalescot, G, additional
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- 2023
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22. Characteristics, risk factors and outcomes of patients managed for left-sided infective endocarditis: a prospective study in a high-volume center
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Granger, C, primary, Elegamandji, B, additional, Mihoubi, K, additional, Mertens, E, additional, Bouziri, N, additional, Guedeney, P, additional, Lebreton, G, additional, Demondion, P, additional, Bleibtreu, A, additional, Collet, J P, additional, Montalescot, G, additional, Hekimian, G, additional, and Hammoudi, N, additional
- Published
- 2023
- Full Text
- View/download PDF
23. Phenotyping coronary plaque by computed tomography in premature coronary artery disease
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Rahoual, G, primary, Zeitouni, M, additional, Charpentier, E, additional, Ritvo, P G, additional, Rouanet, S, additional, Procopi, N, additional, Boukhelifa, S, additional, Charleux, P, additional, Guedeney, P, additional, Kerneis, M, additional, Barthelemy, O, additional, Silvain, J, additional, Montalescot, G, additional, and Collet, J P, additional
- Published
- 2023
- Full Text
- View/download PDF
24. P2Y12 inhibitor loading time before elective PCI and the prevention of myocardial necrosis
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Roule, V, primary, Beygui, F, additional, Cayla, G, additional, Range, G, additional, Motovska, Z, additional, Delarche, N, additional, Jourda, F, additional, Goube, P, additional, Guedeney, P, additional, Zeitouni, M, additional, El Kasty, M, additional, Laredo, M, additional, Vicaut, E, additional, Montalescot, G, additional, and Silvain, J, additional
- Published
- 2023
- Full Text
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25. Appropriate ischemic criteria for type 4a myocardial infarction: insights from the ALPHEUS trial
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Roule, V, primary, Zeitouni, M, additional, Guedeney, P, additional, Beygui, F, additional, El Kasty, M, additional, Braik, N, additional, Bertin, B, additional, Brugier, D, additional, Range, G, additional, Motovska, Z, additional, Cayla, G, additional, Vicaut, E, additional, Montalescot, G, additional, and Silvain, J, additional
- Published
- 2023
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26. In vitro comparison of platelet aggregation between zalunfiban and selatogrel in healthy donors
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Rikken, A O F, primary, Van 'T Hof, A W J, additional, Gibson, C M, additional, Granger, C B, additional, Montalescot, G, additional, Curry, B J, additional, Jennings, L K, additional, and Ten Berg, J M, additional
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- 2023
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27. Early versus delayed introduction of renin angiotensin aldosterone system inhibitors in cardiogenic shock
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Sulman, D, primary, Zeitouni, M, additional, Beaupre, F, additional, Devos, P, additional, Procopi, N, additional, Kerneis, M, additional, Guedeney, P, additional, Hammoudi, N, additional, Rouanet, S, additional, Brugier, D, additional, Combes, A, additional, Hekimian, G, additional, Collet, J P, additional, Montalescot, G, additional, and Silvain, J, additional
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- 2023
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28. Neurohormonal status is associated with long-term appropriate implantable cardioverter defibrillator therapy for life-threatening ventricular arrhythmia
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Beygui, F, primary, Roule, V, additional, Guedeney, P, additional, Werner, T, additional, Zeitouni, M, additional, Ollitraut, P, additional, Silvain, J, additional, Alexandre, J, additional, Collet, J P, additional, Milliez, P, additional, and Montalescot, G, additional
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- 2023
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29. Synergistic effect of Interleukin-1beta and cholesterol efflux capacity on outcomes in acute myocardial infarction patients
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Materne, C, primary, Silvain, J, additional, Zeitouni, M, additional, Guedeney, P, additional, Galier, S, additional, Guillas, I, additional, Lhomme, M, additional, Frisdal, E, additional, Vicaut, E, additional, Lesnik, P, additional, Collet, J P, additional, Le Goff, W, additional, Montalescot, G, additional, Kerneis, M, additional, and Guerin, M, additional
- Published
- 2023
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30. Prise en charge de l’infarctus du myocarde, nouveautés des Recommandation ESC 2017
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Braik, N., Ecollan, P., and Montalescot, G.
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- 2018
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31. Thrombose coronaire : physiopathologie et traitement à l’ère de la médecine personnalisée
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Zeitouni, M., Silvain, J., Kerneis, M., Guedeney, P., Overtchouk, P., Barthelemy, O., Hauguel-Moreau, M., Montalescot, G., and Collet, J.-P.
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- 2017
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32. Exercise-induced pulmonary congestion assessed by lung ultra sound in patients with preserved left ventricular ejection fraction referred for exercise echocardiography to rule out myocardial ischemia
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Granger, C., primary, Legrand, L., additional, Allali, Y., additional, Guedeney, P., additional, Isnard, R., additional, Pousset, F., additional, Collet, J.P., additional, Montalescot, G., additional, and Hammoudi, N., additional
- Published
- 2023
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33. Microtransesophageal echocardiographic guidance of patent foramen ovale percutaneous closure
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Bouziri, N., primary, Guedeney, P., additional, Malvy, J., additional, Zeitouni, M., additional, Mertens, E., additional, Ceccaldi, A., additional, Wallet, T., additional, Silvain, J., additional, Montalescot, G., additional, and Hammoudi, N., additional
- Published
- 2023
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34. Exercise-induced ventricular arrythmia in patients with mitral valve prolapse
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Wallet, T., primary, Al Mohani, A., additional, Waintraub, X., additional, Berman, E., additional, Mertens, E., additional, Bouziri, N., additional, Allali, Y., additional, Helft, G., additional, Lefeuvre, C., additional, Isnard, R., additional, Montalescot, G., additional, and Hammoudi, N., additional
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- 2023
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35. Main air pollutants and out-of-hospital cardiac arrest: A systematic review and meta-analysis
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Mustafic, H.A., primary, Zeitouni, M., additional, Celebic, A., additional, Gandjbakhch, E., additional, Charron, P., additional, and Montalescot, G., additional
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- 2023
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36. Comparison of the safety and efficacy of antithrombotic regimens following TAVR in patients without having an indication for chronic oral anticoagulation
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Guedeney, P, primary, Roule, V, additional, Mesnier, J, additional, Chapelle, C, additional, Portal, J J, additional, Laporte, S, additional, Ollier, E, additional, Zeitouni, M, additional, Kerneis, M, additional, Barthelemy, O, additional, Sorrentino, S, additional, Silvain, J, additional, Vicaut, E, additional, Montalescot, G, additional, and Collet, J P, additional
- Published
- 2022
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37. Direct stenting versus stenting after predilatation in STEMI patients with high thrombus burden: a subanalysis from the randomized COMPARE CRUSH trial
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Vogel, R F, primary, Delewi, R, additional, Wilschut, J M, additional, Lemmert, M E, additional, Diletti, R, additional, Nuis, R J, additional, Paradies, V, additional, Alexopoulos, D, additional, Zijlstra, F, additional, Montalescot, G, additional, Angiolillo, D J, additional, Krucoff, M W, additional, Van Mieghem, N M, additional, Smits, P C, additional, and Vlachojannis, G J, additional
- Published
- 2022
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38. Supraventricular arrhythmia following patent foramen ovale percutaneous closure
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Guedeney, P, primary, Laredo, M, additional, Zeitouni, M, additional, Hauguel-Moreau, M, additional, Wallet, T, additional, Alamowitch, S, additional, Sabben, C, additional, Deltour, S, additional, Benyounes, N, additional, Obadia, M, additional, Collet, J P, additional, Rouanet, S, additional, Hammoudi, N, additional, Silvain, J, additional, and Montalescot, G, additional
- Published
- 2022
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39. Exercise-induced ventricular arrythmia in asymptomatic patients with Mitral Valve Prolapse
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Wallet, T, primary, Al Mohani, A, additional, Waintraub, X, additional, Berman, E, additional, Mertens, E, additional, Bouziri, N, additional, Allali, Y, additional, Helft, G, additional, Lefeuvre, C, additional, Isnard, R, additional, Montalescot, G, additional, and Hammoudi, N, additional
- Published
- 2022
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40. Outcomes following patent foramen ovale percutaneous closure according to the delay from last ischemic event
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Guedeney, P, primary, Mesnier, J, additional, Michel, M, additional, Hauguel-Moreau, M, additional, Silvain, J, additional, Houde, C, additional, Alperi, A, additional, Panagides, V, additional, Collet, J P, additional, Wallet, T, additional, Rouanet, S, additional, Hammoudi, N, additional, Rodes-Cabau, J, additional, and Montalescot, G, additional
- Published
- 2022
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41. Have the ESC guidelines improved the identification and prevention of individuals at risk of premature myocardial infarction?
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Zeitouni, M, primary, Sulman, D, additional, Silvain, J, additional, Kerneis, M, additional, Guedeney, P, additional, Barthelemy, O, additional, Procopi, N, additional, Collet, J P, additional, and Montalescot, G, additional
- Published
- 2022
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42. Comprehensive Assessment of Coronary Artery Disease in Sports-Related Sudden Cardiac Arrest
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Karam, Nicole, Pechmajou, Louis, Dumas, Florence, Bougouin, Wulfran, Sharifzadehgan, Ardalan, Beganton, Frankie, Bonnet, Guillaume, Jost, Daniel, Lamhaut, Lionel, Varenne, Olivier, Aubry, Pierre, Sideris, Georgios, Spaulding, Christian, Cariou, Alain, Marijon, Eloi, Jouven, Xavier, Adnet, F, Agostinucci, JM, Aissaoui-Balanant, N, Algalarrondo, V, Alla, F, Alonso, C, Amara, W, Annane, D, Antoine, C, Aubry, P, Azoulay, E, Beganton, F, Benhamou, D, Bougouin, W, Bruel, C, Brun Buisson, C, Bruneval, P, Cariou, A, Carli, P, Cerf, C, Chaib, A, Chastre, J, Cholley, B, Cohen, Y, Combes, A, Cornaglia, C, Coulaud, JM, Da Silva, D, Das, V, Deye, N, Dhonneur, G, Diehl, JL, Dinanian, S, Domanski, L, Dreyfuss, D, Duboc, D, Dubois-Rande, JL, Mansencal, N, Duchateau, FX, Duguet, A, Dumas, F, Empana, JP, Extramiana, F, Fartoukh, M, Fenioux, C, Fraisse, F, Gabbas, M, Gandjbakhch, E, Guidet, B, Halimi, F, Henry, P, Hidden Lucet, F, Jabre, P, Jacob, L, Joseph, L, Jost, D, Journois, D, Jouven, X, Karam, N, Lacotte, J, Lahlou-Laforet, K, Lamhaut, L, Lanceleur, A, Langeron, O, Lanoe, V, Lavergne, T, Lecarpentier, E, Leenhardt, A, Lellouche, N, Lemiale, V, Linval, F, Loeb, T, Ludes, B, Mansouri, N, Marijon, E, Marty, J, Maury, E, Maxime, V, Mekontso-Dessaps, A, Mira, JP, Misset, B, Monnet, X, Montalescot, G, Narayanan, K, Nicolas-Robin, A, Perier, MC, Piot, O, Plu, I, Revaux, F, Ricard, JD, Richard, C, Riou, B, Rouby, JJ, Santoli, F, Schortgen, F, Sharshar, T, Sideris, G, Similowski, T, Simon, A, Spaulding, C, Steg, G, Teboul, JL, Timsit, JF, Tourtier, JP, Tuppin, P, Ursat, C, Varenne, O, Vieillard-Baron, A, Voicu, S, Wahbi, K, Waldmann, V, and Wolff, M
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- 2018
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43. Results from the nationwide French registry ODIACOR. A call to optimize risk factors control and reach the targets in coronary diabetic patients
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Sabouret, P., primary, Dib, J.-C., additional, Sharareh, A., additional, Dievart, F., additional, Hoffman, O., additional, Huberman, J.-P., additional, Montalescot, G., additional, and Lellouche, N., additional
- Published
- 2022
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44. Prise en charge de l’infarctus du myocarde en 2012
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Cayla, G., Silvain, J., Ecollan, P., Montalescot, G., and Collet, J.-P.
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- 2012
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45. Résistance au clopidogrel, tests génétiques et tests fonctionnels
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Hulot, J.-S., Collet, J.-P., and Montalescot, G.
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- 2012
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46. Combinatorial, additive and dose-dependent drug-microbiome associations
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Forslund, SK, Chakaroun, R, Zimmermann-Kogadeeva, M, Markó, L, Aron-Wisnewsky, J, Nielsen, T, Moitinho-Silva, L, Schmidt, TSB, Falony, G, Vieira-Silva, S, Adriouch, S, Alves, RJ, Assmann, K, Bastard, J-P, Birkner, T, Caesar, R, Chilloux, J, Coelho, LP, Fezeu, L, Galleron, N, Helft, G, Isnard, R, Ji, B, Kuhn, M, Le Chatelier, E, Myridakis, A, Olsson, L, Pons, N, Prifti, E, Quinquis, B, Roume, H, Salem, J-E, Sokolovska, N, Tremaroli, V, Valles-Colomer, M, Lewinter, C, Søndertoft, NB, Pedersen, HK, Hansen, TH, Amouyal, C, Andersson Galijatovic, EA, Andreelli, F, Barthelemy, O, Batisse, J-P, Belda, E, Berland, M, Bittar, R, Blottière, H, Bosquet, F, Boubrit, R, Bourron, O, Camus, M, Cassuto, D, Ciangura, C, Collet, J-P, Dao, M-C, Djebbar, M, Doré, A, Engelbrechtsen, L, Fellahi, S, Fromentin, S, Galan, P, Gauguier, D, Giral, P, Hartemann, A, Hartmann, B, Holst, JJ, Hornbak, M, Hoyles, L, Hulot, J-S, Jaqueminet, S, Jørgensen, NR, Julienne, H, Justesen, J, Kammer, J, Krarup, N, Kerneis, M, Khemis, J, Kozlowski, R, Lejard, V, Levenez, F, Lucas-Martini, L, Massey, R, Martinez-Gili, L, Maziers, N, Medina-Stamminger, J, Montalescot, G, Moute, S, Neves, AL, Olanipekun, M, Le Pavin, LP, Poitou, C, Pousset, F, Pouzoulet, L, Rodriguez-Martinez, A, Rouault, C, Silvain, J, Svendstrup, M, Swartz, T, Vanduyvenboden, T, Vatier, C, Walther, S, Gøtze, JP, Køber, L, Vestergaard, H, Hansen, T, Zucker, J-D, Hercberg, S, Oppert, J-M, Letunic, I, Nielsen, J, Bäckhed, F, Ehrlich, SD, Dumas, M-E, Raes, J, Pedersen, O, Clément, K, Stumvoll, M, Bork, P, The MetaCardis Consortium (Hoyles, L.), European Molecular Biology Laboratory [Heidelberg] (EMBL), Max Delbrück Center for Molecular Medicine [Berlin] (MDC), Helmholtz-Gemeinschaft = Helmholtz Association, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Berlin Institute of Health (BIH), German Center for Cardiovascular Research (DZHK), Universität Leipzig, Nutrition et obésités: approches systémiques (UMR-S 1269) (Nutriomics), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of Copenhagen = Københavns Universitet (UCPH), University of New South Wales [Sydney] (UNSW), Paul Scherrer Institute (PSI), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Heidelberg University, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Henri Mondor [Créteil], Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], University of Gothenburg (GU), Imperial College London, MetaGenoPolis (MGP (US 1367)), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Paris-Saclay, Institut de cardiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Chalmers University of Technology [Gothenburg, Sweden], Unité de modélisation mathématique et informatique des systèmes complexes [Bondy] (UMMISCO), Université de Yaoundé I-Institut de la francophonie pour l'informatique-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Université Gaston Bergé (Saint-Louis, Sénégal)-Université Cadi Ayyad [Marrakech] (UCA)-Sorbonne Université (SU)-Institut de Recherche pour le Développement (IRD [France-Nord]), Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] (CIC Paris-Est), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Biobyte Solutions [Heidelberg, Germany] (BS), IT University of Copenhagen (ITU), Sahlgrenska University Hospital [Gothenburg], Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283 (EGENODIA (GI3M)), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, McGill University and Genome Quebec Innovation Centre, Helmholtz Institute Ulm (HIU), Helmholtz Zentrum München = German Research Center for Environmental Health, University of Würzburg = Universität Würzburg, Yonsei University, MetaCardis Consortium*: Chloe Amouyal, Ehm Astrid Andersson Galijatovic, Fabrizio Andreelli, Olivier Barthelemy, Jean-Paul Batisse, Eugeni Belda, Magalie Berland, Randa Bittar, Hervé Blottière, Frederic Bosquet, Rachid Boubrit, Olivier Bourron, Mickael Camus, Dominique Cassuto, Cecile Ciangura, Jean-Philippe Collet, Maria-Carlota Dao, Morad Djebbar, Angélique Doré, Line Engelbrechtsen, Soraya Fellahi, Sebastien Fromentin, Pilar Galan, Dominique Gauguier, Philippe Giral, Agnes Hartemann, Bolette Hartmann, Jens Juul Holst, Malene Hornbak, Lesley Hoyles, Jean-Sebastien Hulot, Sophie Jaqueminet, Niklas Rye Jørgensen, Hanna Julienne, Johanne Justesen, Judith Kammer, Nikolaj Krarup, Mathieu Kerneis, Jean Khemis, Ruby Kozlowski, Véronique Lejard, Florence Levenez, Lea Lucas-Martini, Robin Massey, Laura Martinez-Gili, Nicolas Maziers, Jonathan Medina-Stamminger, Gilles Montalescot, Sandrine Moute, Ana Luisa Neves, Michael Olanipekun, Laetitia Pasero Le Pavin, Christine Poitou, Francoise Pousset, Laurence Pouzoulet, Andrea Rodriguez-Martinez, Christine Rouault, Johanne Silvain, Mathilde Svendstrup, Timothy Swartz, Thierry Vanduyvenboden, Camille Vatier, Stefanie Walther., ANR-16-IDEX-0004,ULNE,ULNE(2016), ANR-18-IBHU-0001,PreciDIAB,PreciDIAB Institute, the holistic approach of personal diabets care(2018), Dumas, Marc-Emmanuel, Universität Leipzig [Leipzig], Service de Nutrition [CHU Pitié-Salpétrière], Institut E3M [CHU Pitié-Salpêtrière], CHU Henri Mondor, Centre d'investigation clinique pluridisciplinaire [CHU Pitié Salpêtrière] (CIC-1901(ex CIC-1421)), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Imperial College London - National Heart and Lung Institute, and Division of Computational and Systems Medicine, Imperial College London, London, SW7 2AZ, UK
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Clostridiales ,Science & Technology ,Multidisciplinary ,ANTIBIOTIC USE ,IMPACT ,Microbiota ,[SDV]Life Sciences [q-bio] ,HUMAN GUT MICROBIOME ,Atherosclerosis ,Gastrointestinal Microbiome ,[SDV] Life Sciences [q-bio] ,Multidisciplinary Sciences ,PROTON PUMP INHIBITORS ,Cardiovascular and Metabolic Diseases ,GUIDELINE ,Metabolome ,MANAGEMENT ,Humans ,Science & Technology - Other Topics ,ALTERS - Abstract
During the transition from a healthy state to cardiometabolic disease, patients become heavily medicated, which leads to an increasingly aberrant gut microbiome and serum metabolome, and complicates biomarker discovery1-5. Here, through integrated multi-omics analyses of 2,173 European residents from the MetaCardis cohort, we show that the explanatory power of drugs for the variability in both host and gut microbiome features exceeds that of disease. We quantify inferred effects of single medications, their combinations as well as additive effects, and show that the latter shift the metabolome and microbiome towards a healthier state, exemplified in synergistic reduction in serum atherogenic lipoproteins by statins combined with aspirin, or enrichment of intestinal Roseburia by diuretic agents combined with beta-blockers. Several antibiotics exhibit a quantitative relationship between the number of courses prescribed and progression towards a microbiome state that is associated with the severity of cardiometabolic disease. We also report a relationship between cardiometabolic drug dosage, improvement in clinical markers and microbiome composition, supporting direct drug effects. Taken together, our computational framework and resulting resources enable the disentanglement of the effects of drugs and disease on host and microbiome features in multimedicated individuals. Furthermore, the robust signatures identified using our framework provide new hypotheses for drug-host-microbiome interactions in cardiometabolic disease. ispartof: NATURE vol:600 issue:7889 pages:500-+ ispartof: location:England status: published
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- 2021
47. Therapeutic Ultrasound Peripheral and Coronary Angioplasty Using the Angioson System
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Drobinski, G., Brisset, D., Philippe, F., Kremer, D., Montalescot, G., Thomas, D., and Siegel, Robert J., editor
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- 1996
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48. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial
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Bhatt, D, Steg, P, Mehta, S, Leiter, L, Simon, T, Fox, K, Held, C, Andersson, M, Himmelmann, A, Ridderstrale, W, Chen, J, Song, Y, Diaz, R, Goto, S, James, S, Ray, K, Parkhomenko, A, Kosiborod, M, Mcguire, D, Harrington, R, Santos, V, Jain, A, Lendel, I, Russo, M, Haught, W, Bouza, M, Gogia, H, Banerjee, S, Kichura, G, Kantaros, L, Padron, F, Passi, R, Stone, J, Pursley, M, D'Urso, M, Gardner, T, Bennett, J, Nour, K, Saini, S, Zhang, W, Kumbhani, D, Thomas, D, Angiolillo, D, Bertolet, B, Roman-Miranda, A, Black, R, Manshadi, R, Vaca, C, Blanco, A, Napoli, M, Brabham, D, Akyea-Djamson, A, Desai, P, Prasada, S, Khaira, A, Forgosh, L, Lieber, I, Umpierrez, G, Singal, D, Londono, J, Fraser, N, Ruiz, J, Vega, D, Rodriguez, L, Brown, C, Syed, F, Aggarwala, G, Eaves, W, Foster, M, Gupta, D, Avino, D, Asfour, W, Tonnessen, G, Zhao, X, Singh, N, Brockmyre, A, Lepor, N, Shammas, N, Blick, D, Hearne, S, Prodafikas, J, Carell, E, Izzo, M, Karim, A, Zakhary, B, Atieh, M, Leichter, S, Meadows, C, Hotchkiss, D, Abu-Fadel, M, Wiseman, A, Bander, J, Shah, M, Ganim, R, Sopko, K, Khan, M, Lloret, R, Weirick, T, Mehta, R, Thadani, U, Bhargava, A, Moya, J, Staniloae, C, Guerra, Y, Chhabra, A, Kosmicki, D, Shaheen, W, Mohammed, A, Bitters, J, Pattanayak, J, Javier, J, Srivastava, S, Phillips, R, Al-Amin, J, Lillestol, M, Simpson, P, Hazan, L, Amin, A, Shah, G, Korpas, D, Platt, B, Dickert, J, Puente, O, Hiotis, L, Doyle, T, Rajan, R, Meholick, A, Gring, C, Hage-Korban, E, Feldman, R, Colfer, H, Butman, S, Hart, T, Huling, R, Eshaghian, S, Quintana, O, Cheung, D, Handel, F, Rodriguez, M, Suh, D, Gordon, P, Pressman, G, Bauer, M, French, W, Barettella, M, Chatrathi, S, Suresh, D, Goldberg, R, Huth, M, Younis, L, Rahman, A, Mascolo, R, Welch, M, Suneja, R, Smith, S, Shurmur, S, Agaiby, J, Jingo, A, Johnston, J, Beth, M, Vlastaris, A, Kemp, S, Taheri, H, Pereira, E, Deyoung, M, Hawa, Z, Smith, R, Galski, T, Garas, S, Reddy, M, Sharma, S, Hargrove, J, Treasure, C, Emerson, R, Haddad, T, Rohr, K, Levinson, L, Gaona, R, Uretsky, B, Maheshwari, H, Lee, D, Kinnaman, S, Singal, R, Geohas, J, Gigliotti, O, Raisinghani, A, Khurana, C, Hella, B, Kelberman, M, Voyce, S, Singh, S, Lo, E, Singh, P, Goodfellow, R, Fischer, S, Lorraine, R, Turner, T, Shanes, J, Busch, R, Broker, R, Zaniewski, M, Pounds, K, Debs-Perez, G, Ong, S, Frandsen, B, Fullington, D, Jaffrani, N, Khan, A, Lee, M, Pouzar, J, Revtyak, G, Gonzalez, J, Nakhle, S, Murillo, A, Young, D, Makam, S, Syed, M, Woolf, K, Grena, P, Alfata, S, Mahal, S, Hoffman, D, Kizhakekuttu, T, Deering, J, Bhavsar, J, Mikesell, S, Wilson, W, Wilson, V, El, S, Spinale, F, Kannarkat, V, Rao, S, Hanson, L, Bertsch, J, Gonzalez-Ortiz, E, Severino, N, Willis, J, Schock, J, Bakhtari, L, Gazmuri, R, Ansari, S, Hall, J, Mehta, A, Shealy, N, Zarich, S, Singh, D, Vora, K, Andrawis, N, Molter, D, Maron, D, Cardona, J, D'Agostino, R, Arshad, T, Samaan, R, Jones, D, Presser, D, Heath, J, Green, S, Bittar, G, Henry, S, Korn, D, Schmedtje, J, Nadar, V, Graham, B, Labroo, A, Clavijo, L, Roseman, H, Ledesma, G, Rosen, R, Dor, I, Kirby, W, Sutton, J, Eder, F, Iteld, B, Gomez-Cortes, J, Buchbinder, M, Kasper, J, Terrelonge, A, Torres, G, Jagielo, T, Alvarez, J, Handelsman, Y, Guillen, M, Richwine, R, Lewy-Alterbaum, L, Corder, C, Arvind, M, Bolshoun, D, Mikhail, M, Minton, S, Alvarado, O, Abbott, J, Cauthen, B, Welter, R, Mintz, R, Cox, J, Quick, A, Weiss, M, Dy, J, Zebrack, J, Gandelman, G, Hegde, V, Silver, M, Degregorio, M, Lawson, W, Paa, C, Bortnick, A, Krolick, M, Sotolongo, R, Cheirif, J, Kumar, P, Jetty, P, Patel, A, Kruk, M, Kobielusz-Gembala, I, Rewerska, B, Madrzejewski, A, Milewski, K, Cygler, J, Petryka-Mazurkiewicz, J, Jastrzebski, W, Korecki, J, Fil, W, Prokopczuk, J, Bochenek, A, Wujkowski, M, Witek, R, Konczakowski, P, Miekus, P, Szczasny, M, Musial, W, Cymerman, K, Lampart, J, Mikosinski, J, Szynal, S, Fares, I, Opolski, G, Mazur, S, Wozakowska-Kaplon, B, Bijata-Bronisz, R, Wierucki, L, Losa, B, Drelich, G, Konieczny, M, Starczewski, P, Pawlowicz, L, Jesionowski, P, Jurowiecki, J, Gniot, J, Czyzycki, M, Stania, K, Kucharczyk-Bauman, I, Busz-Papiez, B, Karczmarczyk, A, Sudnik, W, Koszek, A, Kolodziej, P, Skwarna, B, Jaramillo, N, Jankowski, M, Czochra, W, Kinasz, L, Miklaszewicz, B, Stasinska, T, Pluta, W, Basiak, M, Rusicka, T, Niedbal-Yahfouf, I, Popenda, G, Korzeniak, R, Mirek, A, Mariankowski, R, Wojnowski, L, Korol, M, Baszak, J, Podolec, P, Piesiewicz, W, Zurakowski, A, Luengas, C, Skura, M, Pilecki, P, Majchrzak, P, Krzyzagorska, E, Drozd, M, Kaczmarek, B, Sliwinska, T, Zelazowska, K, Sztembis, R, Landa, K, Matyszczak-Toniak, L, Strojek, K, Piepiorka, M, Malinowski, R, Gorska, M, Stolarczyk-Sowa, E, Romanowski, L, Zinka, E, Reszka, Z, Skierkowska, J, Uzunow, A, Laskowska-Derlaga, E, Puntus, E, Kosmacheva, E, Koziolova, N, Pavlov, P, Supryadkina, T, Didenko, Y, Kopylov, P, Kazakov, A, Aksentiev, S, Vishneva, E, Repin, A, Smolenskaya, O, Mantserova, O, Khrustalev, O, Privalova, E, Konstantinov, V, Boldueva, S, Ezhov, A, Chernyavsky, A, Kamalov, G, Galyavich, A, Zubeeva, G, Nechaeva, G, Shustov, S, Dzhaiani, N, Treshkur, T, Osokina, N, Panov, A, Shutemova, E, Makukhin, V, Kropotina, T, Tsyba, L, Karpov, Y, Sizova, J, Ballyuzek, M, Tarasov, N, Demchenko, E, Barbarash, O, Moiseev, V, Markov, V, Kuznetsov, V, Viktorova, I, Sergienko, I, Ermoshkina, L, Khasanov, N, Khlevchuk, T, Baglikov, A, Shalaev, S, Zonova, E, Reznik, E, Haisheva, L, Morugova, T, Lomakin, N, Vishnevsky, A, Shvarts, Y, Magnitskaya, O, Mikhailusova, M, Pavlysh, E, Libov, I, Zateyschikova, A, Kostenko, V, Edin, A, Khovaeva, Y, Zakharov, K, Stryuk, R, Khirmanov, V, Kanorskiy, S, Yakushin, S, Barabashkina, A, Li, H, Zhao, Q, Zhang, J, Ma, J, He, Y, Luo, M, Zhang, A, Zhang, N, Chai, Y, Ma, G, Wang, H, Liu, Z, He, L, Song, Z, Dong, X, Tao, L, Li, Z, Su, X, Kong, X, Niu, H, Ge, J, Luo, Z, Huang, W, Peng, D, Yuan, Z, Milanova, M, Tenev, D, Gogov, A, Karageorgiev, D, Kolchev, T, Rusev, N, Georgieva, N, Kondov, R, Rusinov, V, Petrov, I, Stanchev, G, Konteva, M, Dincheva, A, Yaneva, Z, Vatova, R, Ilieva, K, Runev, N, Kolomanov, B, Iliev, N, Tisheva, S, Chompalova, B, Tokmakova, M, Raev, D, Byanov, K, Markov, D, Mihov, L, Mihov, A, Milcheva, N, Minchev, M, Mollov, M, Borisov, B, Tihchev, T, Karakolev, V, Dimov, B, Georgiev, S, Smilov, L, Koo, B, Ahn, T, Hong, S, Yoon, J, Oh, S, Jeong, M, Kim, D, Chang, K, Kim, W, Hahn, J, Cha, K, Lee, J, Choi, S, Nam, C, Chae, I, Park, Y, Tahk, S, Shin, W, Chae, J, Kim, B, Bae, J, Park, W, Rha, S, Choi, Y, Hwang, J, Park, H, Baracioli, L, Guimaraes, F, Vasconcellos, E, Saraiva, J, Pereira, A, Santos, Q, Rossi, P, Maia, L, Madeira, M, Pereira, M, Botelho, R, Reis, G, Eliaschewitz, F, Borges, J, Nascimento, C, Fortes, J, de Souza, W, Pimentel, P, Hissa, M, Franchetti, M, Precoma, D, Ortiz, C, Hernandes, M, Saporito, W, dos Santos, F, Kormann, A, Neuenschwander, F, Dutra, O, Rassi, N, Tanajura, L, Souza, J, Junior, D, Leaes, P, Forte, A, Bonansea, T, 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C., Istratoaie O., Coman I., Militaru C., Cinteza M., Sinnaeve P. R., Nicolau J. C., Kerr Saraiva J. F., Widimsky P., Kristensen S. D., Hartikainen J., Darius H., Tse H. F., Pais P., Lev E., de Luca L., Ramos Lopez G. A., Kontny F., Babilonia N. A., Zateyshchikov D. A., Ruda M., Elamin O., Kovar F., Dalby A. J., Bueno H., Chiang C. -E., Parkhomenko A., Nguyen T. Q., and Leonsson-Zachrisson M.
- Abstract
Background: Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor. Methods: The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population). Findings: Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, pinteraction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo
- Published
- 2019
49. Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial
- Author
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A., and McClanahan M. A.
- Abstract
Background: After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4–1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes. Methods: ODYSSEY OUTCOMES was a randomised, double-blind, placebo-controlled trial, done at 1315 sites in 57 countries, that compared alirocumab with placebo in patients who had been admitted to hospital with an acute coronary syndrome (myocardial infarction or unstable angina) 1–12 months before randomisation and who had raised concentrations of atherogenic lipoproteins despite use of high-intensity statins. Patients were randomly assigned (1:1) to receive alirocumab or placebo every 2 weeks; randomisation was stratified by country and was done centrally with an interactive voice-response or web-response system. Alirocumab was titrated to target LDL cholesterol concentrations of 0·65–1·30 mmol/L. In this prespecified analysis, we investigated the effect of alirocumab on cardiovascular events by glycaemic status at baseline (diabetes, prediabetes, or normoglycaemia)—defined on the basis of patient history, review of medical records, or baseline HbA1c or fasting serum glucose—and risk of new-onset diabetes among those without diabetes at baseline. The primary endpoint was a composite of death from coronary heart disease, non-fatal myocardial infarction, fatal or non-fatal ischaemic stroke, or unstable angina requiring
- Published
- 2019
50. Supplement to: Prehospital ticagrelor in ST-segment elevation myocardial infarction.
- Author
-
Montalescot, G, van ʼt Hof, A W, and Lapostolle, F
- Published
- 2014
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