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3 results on '"Montagnini D"'

1. The schistosomicidal activity of ethanolic extracts from branches, leaves, flowers and fruits of Handroanthus impetiginosus (Mart. ex DC.) Mattos (Bignoniaceae) plant and metabolic profile characterization by UPLC-ESI-QTOF analysis

Author

Montagnini, D. L., primary, Katchborian-Neto, A., additional, Tahan, M. P. M., additional, Oliveira, N. D., additional, Magalhães, L. G., additional, Januário, A. H., additional, Pauletti, P. M., additional, Cavallari, P. S. S. R., additional, Cunha, W. R, additional, Araujo, O. P., additional, Soares, M. G., additional, Ferreira, M. S., additional, Andrade, J. V., additional, Miranda, G. S., additional, Santos, M. F. C, additional, and Silva, M. L. A. e, additional

Published
2023
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3. In Vivo and in Silico Trypanocidal Activity Evaluation of (-)-Cubebin Encapsulated in PLGA Microspheres as Potential Treatment in Acute Phase.

Author

Neres NBR, Montagnini D, Ferreira DS, Parreira RLT, Orenha RP, Lima TC, Molina EF, Cunha WR, Silva MLA, and Esperandim VR

Subjects
Animals, Capsules, Injections, Intraperitoneal, Lignans administration & dosage, Lignans chemistry, Male, Mice, Mice, Inbred BALB C, Molecular Docking Simulation, Parasitic Sensitivity Tests, Trypanocidal Agents administration & dosage, Trypanocidal Agents chemistry, Lignans pharmacology, Microspheres, Trypanocidal Agents pharmacology, Trypanosoma cruzi drug effects
Abstract

In this study, the trypomastigotes of a Y strain of Trypanosoma cruzi were inoculated intraperitoneally into male BALB/c mice weighing approximately 25 g each, which were divided into groups for evaluation of the trypanocidal activity. For the treatment of experimental groups, encapsulated and unencapsulated (-)-cubebin, Benznidazole, and two groups as negative controls were used. The encapsulated (-)-cubebin showed a 68.1 % encapsulation efficiency. The parasitemia peak of substances remained around the 9 th day after the observed reduction in the number of circulating trypomastigotes. The encapsulated (-)-cubebin and (-)-cubebin unloaded showed a decrease of 61.3 % and 58.5 % in the number of parasites as compared to the negative control, respectively. Moreover, animals treated with encapsulated (-)-cubebin had a higher survival time as compared to the other groups. In conclusion, the results obtained were more promising for encapsulated (-)-cubebin as compared to unloaded particles., (© 2021 Wiley-VHCA AG, Zurich, Switzerland.)

Published
2021
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