1. Model compounds for evaluating the reactivity of amphetamine-type stimulants.
- Author
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Milanovic MM, Montagnat OD, Pearson JR, Conlan XA, and Pfeffer FM
- Subjects
- Spectroscopy, Fourier Transform Infrared, Humans, Ephedrine chemistry, Colorimetry, Phenylpropanolamine chemistry, Pseudoephedrine chemistry, Models, Chemical, Amphetamines chemistry, Magnetic Resonance Spectroscopy, Central Nervous System Stimulants chemistry
- Abstract
The use of controlled precursors for reaction optimisation is not always practical. One approach to limiting the use of controlled substances is to instead use 'model compounds'. Herein, two model compounds resembling norephedrine and ephedrine were selected based on their (i) structural similarity (i.e., presence of key functional groups) and (ii) availability from multiple suppliers without restriction. Model compounds 2-amino-1-phenylethanol and 2-(methylamino)-1-phenylethanol (halostachine), were compared to norephedrine and pseudoephedrine by firstly subjecting them to transformations known in the synthesis of amphetamines, and secondly, comparing the compounds using colourimetric spot tests, FTIR and NMR., Competing Interests: Declaration of Competing Interest none, (Crown Copyright © 2024. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
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