Search

Your search keyword '"Monsel, Antoine"' showing total 405 results
Start Over Author "Monsel, Antoine"
405 results on '"Monsel, Antoine"'

1. Thrombolysis before venoarterial ECMO for high-risk pulmonary embolism: a retrospective cohort study

Author

Levy, David, Saura, Ouriel, Passarelli, Maria Teresa, Lucenteforte, Manuela, Lebreton, Guillaume, Bougle, Adrien, Monsel, Antoine, Ortuno, Sofia, Benitha, Yoël, Hammoudi, Nadjib, Assouline, Benjamin, Petit, Matthieu, Gautier, Melchior, Le Fevre, Lucie, Pineton de Chambrun, Marc, Juvin, Charles, Chommeloux, Juliette, Luyt, Charles-Edouard, Hékimian, Guillaume, Leprince, Pascal, Combes, Alain, and Schmidt, Matthieu

Published
2024
Full Text
View/download PDF

3. Treatment of COVID-19-associated ARDS with umbilical cord-derived mesenchymal stromal cells in the STROMA-CoV-2 multicenter randomized double-blind trial: long-term safety, respiratory function, and quality of life

Author

Sitbon, Alexandre, Hauw-Berlemont, Caroline, Mebarki, Miryam, Heming, Nicholas, Mayaux, Julien, Diehl, Jean-Luc, Demoule, Alexandre, Annane, Djillali, Marois, Clémence, Demeret, Sophie, Weiss, Emmanuel, Voiriot, Guillaume, Fartoukh, Muriel, Constantin, Jean‐Michel, Mégarbane, Bruno, Plantefève, Gaëtan, Boucher-Pillet, Hélène, Churlaud, Guillaume, Cras, Audrey, Maheux, Camille, Pezzana, Chloé, Diallo, Mamadou Hassimiou, Lebbah, Said, Ropers, Jacques, Salem, Joe-Elie, Straus, Christian, Menasché, Philippe, Larghero, Jérôme, and Monsel, Antoine

Published
2024
Full Text
View/download PDF

4. Impact of COVID-19 on posttraumatic stress disorder in ICU survivors: a prospective observational comparative cohort study

Author

Kalfon, Pierre, El-Hage, Wissam, Geantot, Marie-Agnès, Favier, Constance, Bodet-Contentin, Laetitia, Kuteifan, Khaldoun, Olivier, Pierre-Yves, Thévenin, Didier, Pottecher, Julien, Crozon-Clauzel, Jullien, Mauchien, Bénédicte, Galbois, Arnaud, de Varax, Roland, Valera, Sabine, Estagnasie, Philippe, Berric, Audrey, Nyunga, Martine, Revel, Nathalie, Simon, Georges, Kowalski, Benjamin, Sossou, Achille, Signouret, Thomas, Leone, Marc, Delalé, Charles, Seemann, Aurélien, Lasocki, Sigismond, Quenot, Jean-Pierre, Monsel, Antoine, Michel, Olivier, Page, Mathieu, Patrigeon, René-Gilles, Nicola, Walid, Thille, Arnaud W., Hekimian, Guillaume, Auquier, Pascal, and Baumstarck, Karine

Published
2024
Full Text
View/download PDF

8. Association between combination antibiotic therapy as opposed as monotherapy and outcomes of ICU patients with Pseudomonas aeruginosa ventilator-associated pneumonia: an ancillary study of the iDIAPASON trial

Author

Foucrier, Arnaud, Dessalle, Thomas, Tuffet, Sophie, Federici, Laura, Dahyot‑Fizelier, Claire, Barbier, François, Pottecher, Julien, Monsel, Antoine, Hissem, Tarik, Lefrant, Jean‑Yves, Demoule, Alexandre, Constantin, Jean‑Michel, Rousseau, Alexandra, Simon, Tabassome, Leone, Marc, and Bouglé, Adrien

Published
2023
Full Text
View/download PDF

11. Effect of non-invasive ventilation after extubation in critically ill patients with obesity in France: a multicentre, unblinded, pragmatic randomised clinical trial

Author

DE JONG, AUDREY, BIGNON, ANNE, STEPHAN, FRANÇOIS, GODET, THOMAS, CONSTANTIN, JEAN-MICHEL, ASEHNOUNE, KARIM, SYLVESTRE, AUDE, SAUTILLET, JULIETTE, BLONDONNET, RAIKO, FERRANDIERE, MARTINE, SEGUIN, PHILIPPE, LASOCKI, SIGISMOND, ROLLE, AMELIE, FAYOLLE, PIERRE-MARIE, MULLER, LAURENT, PARDO, EMMANUEL, TERZI, NICOLAS, RAMIN, SEVERIN, JUNG, BORIS, ABBACK, PAER-SELIM, GUERCI, PHILIPPE, SARTON, BENJAMINE, ROZE, HADRIEN, DUPUIS, CLAIRE, COUSSON, JOEL, FAUCHER, MARION, LEMIALE, VIRGINIE, CHOLLEY, BERNARD, CHANQUES, GERALD, BELAFIA, FOUAD, HUGUET, HELENA, FUTIER, EMMANUEL, GNIADEK, CLAUDINE, VONARB, AURELIE, PRADES, ALBERT, JAILLET, CARINE, CAPDEVILA, XAVIER, CHARBIT, JONATHAN, GENTY, THIBAUT, REZAIGUIA-DELCLAUX, SAIDA, IMBERT, AUDREY, PILORGE, CATHERINE, CALYPSO, ROMAN, BOUTEAU-DURAND, ASTRID, CARLES, MICHEL, MEHDAOUI, HOSSEN, SOUWEINE, BERTRAND, CALVET, LAURE, JABAUDON, MATTHIEU, RIEU, BENJAMIN, CANDILLE, CLARA, SIGAUD, FLORIAN, RIU, BEATRICE, PAPAZIAN, LAURENT, VALERA, SABINE, MOKART, DJAMEL, CHOW CHINE, LAURENT, BISBAL, MAGALI, POULIQUEN, CAMILLE, DE GUIBERT, JEAN-MANUEL, TOURRET, MAXIME, MALLET, DAMIEN, LEONE, MARC, ZIELESKIEWICZ, LAURENT, COSSIC, JEANNE, ASSEFI, MONA, BARON, ELODIE, QUEMENEUR, CYRIL, MONSEL, ANTOINE, BIAIS, MATTHIEU, OUATTARA, ALEXANDRE, BONNARDEL, ELINE, MONZIOLS, SIMON, MAHUL, MARTIN, LEFRANT, JEAN-YVES, ROGER, CLAIRE, BARBAR, SABER, LAMBIOTTE, FABIEN, SAINT-LEGER, PIEHR, PAUGAM, CATHERINE, POTTECHER, JULIEN, LUDES, PIERRE-OLIVIER, DARRIVERE, LUCIE, GARNIER, MARC, KIPNIS, ERIC, LEBUFFE, GILLES, GAROT, MATTHIAS, FALCONE, JEREMY, CHOUSTERMAN, BENJAMIN, COLLET, MAGALI, GAYAT, ETIENNE, DELLAMONICA, JEAN, MFAM, WILLY-SERGE, OCHIN, EVELINA, NEBLI, MOHAMED, TILOUCHE, NEJLA, MADEUX, BENJAMIN, BOUGON, DAVID, AARAB, YASSIR, GARNIER, FANNY, AZOULAY, ELIE, MOLINARI, NICOLAS, JABER, SAMIR, De Jong, Audrey, Bignon, Anne, Stephan, François, Godet, Thomas, Constantin, Jean-Michel, Asehnoune, Karim, Sylvestre, Aude, Sautillet, Juliette, Blondonnet, Raiko, Ferrandière, Martine, Seguin, Philippe, Lasocki, Sigismond, Rollé, Amélie, Fayolle, Pierre-Marie, Muller, Laurent, Pardo, Emmanuel, Terzi, Nicolas, Ramin, Séverin, Jung, Boris, Abback, Paer-Selim, Guerci, Philippe, Sarton, Benjamine, Rozé, Hadrien, Dupuis, Claire, Cousson, Joel, Faucher, Marion, Lemiale, Virginie, Cholley, Bernard, Chanques, Gerald, Belafia, Fouad, Huguet, Helena, Futier, Emmanuel, Azoulay, Elie, Molinari, Nicolas, and Jaber, Samir

Published
2023
Full Text
View/download PDF

12. Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial

Author

Bouglé, Adrien, Tuffet, Sophie, Federici, Laura, Leone, Marc, Monsel, Antoine, Dessalle, Thomas, and Amour, Julien

Subjects
Bacterial pneumonia -- Care and treatment, Mortality -- France, Pneumonia -- Care and treatment, Clinical trials -- Comparative analysis, Adults -- Comparative analysis, Antibiotics -- Comparative analysis, Labels -- Comparative analysis, Pseudomonas aeruginosa -- Comparative analysis, Health care industry
Abstract

Purpose Duration of antibiotic therapy for ventilator-associated pneumonia (VAP) due to non-fermenting Gram-negative bacilli (NF-GNB), including Pseudomonas aeruginosa (PA) remains uncertain. We aimed to assess the non-inferiority of a short duration of antibiotics (8 days) vs. prolonged antibiotic therapy (15 days) in VAP due to PA (PA-VAP). Methods We conducted a nationwide, randomized, open-labeled, multicenter, non-inferiority trial to evaluate optimal duration of antibiotic treatment in PA-VAP. Eligible patients were adults with diagnosis of PA-VAP and randomly assigned in 1:1 ratio to receive a short-duration treatment (8 days) or a long-duration treatment (15 days). A pre-specified analysis was used to assess a composite endpoint combining mortality and PA-VAP recurrence rate during hospitalization in the intensive care unit (ICU) within 90 days. Results The study was stopped after 24 months due to slow inclusion rate. In intention-to-treat population (n = 186), the percentage of patients who reached the composite endpoint was 25.5% (N = 25/98) in the 15-day group versus 35.2% (N = 31/88) in the 8-day group (difference 9.7%, 90% confidence interval (CI) -1.9%-21.2%). The percentage of recurrence of PA-VAP during the ICU stay was 9.2% in the 15-day group versus 17% in the 8-day group. The two groups had similar median days of mechanical ventilation, of ICU stay, number of extra pulmonary infections and acquisition of multidrug-resistant (MDR) pathogens during ICU stay. Conclusions Our study failed to show the non-inferiority of a short duration of antibiotics in the treatment of PA-VAP, compared to a long duration. The short duration strategy may be associated to an increase of PA-VAP recurrence. However, the lack of power limits the interpretation of this study., Author(s): Adrien Bouglé [sup.1], Sophie Tuffet [sup.2], Laura Federici [sup.3], Marc Leone [sup.4], Antoine Monsel [sup.5], Thomas Dessalle [sup.1], Julien Amour [sup.1], Claire Dahyot-Fizelier [sup.6], François Barbier [sup.7], Charles-Edouard Luyt [...]

Published
2022
Full Text
View/download PDF

13. Mesenchymal Stem Cell–Derived Extracellular Vesicles Decrease Lung Injury in Mice

Author

Hao, Qi, Gudapati, Varun, Monsel, Antoine, Park, Jeong H, Hu, Shuling, Kato, Hideya, Lee, Jae H, Zhou, Li, He, Hongli, and Lee, Jae W

Subjects
Stem Cell Research, Infectious Diseases, Stem Cell Research - Nonembryonic - Human, Lung, Underpinning research, 1.1 Normal biological development and functioning, Aetiology, 2.1 Biological and endogenous factors, Acute Lung Injury, Animals, Escherichia coli, Escherichia coli Infections, Extracellular Vesicles, Humans, Leukotriene B4, Leukotriene C4, Male, Mesenchymal Stem Cells, Mice, Multidrug Resistance-Associated Proteins, Pneumonia, Bacterial, Propionates, Quinolines, RAW 264.7 Cells, Immunology
Abstract

Human mesenchymal stem cell (MSC) extracellular vesicles (EV) can reduce the severity of bacterial pneumonia, but little is known about the mechanisms underlying their antimicrobial activity. In the current study, we found that bacterial clearance induced by MSC EV in Escherichia coli pneumonia in C57BL/6 mice was associated with high levels of leukotriene (LT) B4 in the injured alveolus. More importantly, the antimicrobial effect of MSC EV was abrogated by cotreatment with a LTB4 BLT1 antagonist. To determine the role of MSC EV on LT metabolism, we measured the effect of MSC EV on a known ATP-binding cassette transporter, multidrug resistance-associated protein 1 (MRP1), and found that MSC EV suppressed MRP1 mRNA, protein, and pump function in LPS-stimulated Raw264.7 cells in vitro. The synthesis of LTB4 and LTC4 from LTA4 are competitive, and MRP1 is the efflux pump for LTC4 Inhibition of MRP1 will increase LTB4 production. In addition, administration of a nonspecific MRP1 inhibitor (MK-571) reduced LTC4 and subsequently increased LTB4 levels in C57BL/6 mice with acute lung injury, increasing overall antimicrobial activity. We previously found that the biological effects of MSC EV were through the transfer of its content, such as mRNA, microRNA, and proteins, to target cells. In the current study, miR-145 knockdown abolished the effect of MSC EV on the inhibition of MRP1 in vitro and the antimicrobial effect in vivo. In summary, MSC EV suppressed MRP1 activity through transfer of miR-145, thereby resulting in enhanced LTB4 production and antimicrobial activity through LTB4/BLT1 signaling.

Published
2019

14. TOP-108 Evaluation of the scoring systems dedicated to liver transplantation in acute-on-chronic liver failure (ACLF) in an international multicenter cohort

Author

L'Hermite, Sébastien, primary, Bedoya, José Ursic, additional, Halter, Sébastien, additional, Ichai, Philippe, additional, Ntandja Wandji, Line Carolle, additional, Coilly, Audrey, additional, Camus, Christophe, additional, Jaber, Samir, additional, Taylor, Rhiannon, additional, Dharancy, Sébastien, additional, Thorburn, Douglas, additional, Conti, Filomena, additional, Pageaux, Georges-Philippe, additional, Saliba, Faouzi, additional, Karvellas, Constantine, additional, Monsel, Antoine, additional, Louvet, Alexandre, additional, Bernal, William, additional, and Artru, Florent, additional

Published
2024
Full Text
View/download PDF

16. Correction to: Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial

Author

Bouglé, Adrien, Tuffet, Sophie, Federici, Laura, Leone, Marc, Monsel, Antoine, Dessalle, Thomas, Amour, Julien, Dahyot-Fizelier, Claire, Barbier, François, Luyt, Charles-Edouard, Langeron, Olivier, Cholley, Bernard, Pottecher, Julien, Hissem, Tarik, Lefrant, Jean-Yves, Veber, Benoit, Legrand, Matthieu, Demoule, Alexandre, Kalfon, Pierre, Constantin, Jean-Michel, Rousseau, Alexandra, Simon, Tabassome, and Foucrier, Arnaud

Published
2022
Full Text
View/download PDF

20. Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial

Author

Monsel, Antoine, Hauw-Berlemont, Caroline, Mebarki, Miryam, Heming, Nicholas, Mayaux, Julien, Nguekap Tchoumba, Otriv, Diehl, Jean-Luc, Demoule, Alexandre, Annane, Djillali, Marois, Clémence, Demeret, Sophie, Weiss, Emmanuel, Voiriot, Guillaume, Fartoukh, Muriel, Constantin, Jean-Michel, Mégarbane, Bruno, Plantefève, Gaëtan, Malard-Castagnet, Stéphanie, Burrel, Sonia, Rosenzwajg, Michelle, Tchitchek, Nicolas, Boucher-Pillet, Hélène, Churlaud, Guillaume, Cras, Audrey, Maheux, Camille, Pezzana, Chloé, Diallo, Mamadou Hassimiou, Ropers, Jacques, Menasché, Philippe, and Larghero, Jérôme

Published
2022
Full Text
View/download PDF

22. Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study

Author

Gangneux, Jean-Pierre, Dannaoui, Eric, Fekkar, Arnaud, Luyt, Charles-Edouard, Botterel, Françoise, De Prost, Nicolas, Tadié, Jean-Marc, Reizine, Florian, Houzé, Sandrine, Timsit, Jean-François, Iriart, Xavier, Riu-Poulenc, Béatrice, Sendid, Boualem, Nseir, Saad, Persat, Florence, Wallet, Florent, Le Pape, Patrice, Canet, Emmanuel, Novara, Ana, Manai, Melek, Cateau, Estelle, Thille, Arnaud W, Brun, Sophie, Cohen, Yves, Alanio, Alexandre, Mégarbane, Bruno, Cornet, Muriel, Terzi, Nicolas, Lamhaut, Lionel, Sabourin, Estelle, Desoubeaux, Guillaume, Ehrmann, Stephan, Hennequin, Christophe, Voiriot, Guillaume, Nevez, Gilles, Aubron, Cécile, Letscher-Bru, Valérie, Meziani, Ferhat, Blaize, Marion, Mayaux, Julien, Monsel, Antoine, Boquel, Frédérique, Robert-Gangneux, Florence, Le Tulzo, Yves, Seguin, Philippe, Guegan, Hélène, Autier, Brice, Lesouhaitier, Matthieu, Pelletier, Romain, Belaz, Sorya, Bonnal, Christine, Berry, Antoine, Leroy, Jordan, François, Nadine, Richard, Jean-Christophe, Paulus, Sylvie, Argaud, Laurent, Dupont, Damien, Menotti, Jean, Morio, Florent, Soulié, Marie, Schwebel, Carole, Garnaud, Cécile, Guitard, Juliette, Le Gal, Solène, Quinio, Dorothée, Morcet, Jeff, Laviolle, Bruno, Zahar, Jean-Ralph, and Bougnoux, Marie-Elisabeth

Published
2022
Full Text
View/download PDF

23. Extracorporeal membrane oxygenation network organisation and clinical outcomes during the COVID-19 pandemic in Greater Paris, France: a multicentre cohort study

Author

JUVIN, Charles, SCHOELL, Thibault, D'Alessandro, Cosimo, MARIN, Sofica, NARDONE, Nathalie, DEMONDION, Pierre, MEYER, Horacio, BOUNADER, Karl, MOIROUX, Alexander, AKAMKAM, Ali, FADEL, Guillaume, RANDRIANALISOA, Erwan, CUSQUEL, Sébastien, LE GLOAHEC, Patrice, HIRSCHAUER, Elisabeth, MUSQUET, Fabrice, Jego, Pierre-Marie, Guedes, Hélène, Roy, Théophile, Mercereau, Lina, Corvol, Emmanuel, Laboure, Anne, Vilanove, Flore, Peperoni, Marco, Machado, Dariène, Sely, Aly, Fortanier, Marion, Gantois, Séverine, Tran, Emilie, Bosq, Elisabeth, Fontanier, Aurélie, Morin, Alice, Cousin, Jocelyne, Bovagnet, Stéphanie, Luyt, Charles Edouard, Hekimian, Guillaume, Brechot, Nicolas, Pineton de Chambrun, Marc, Desnos, Cyrielle, Chomeloux, Juliette, Arzoine, Jeremy, Guerin, Emmanuelle, Monsel, Antoine, Voiriot, Guillaume, Levy, David, Baron, Elodie, Beurton, Alexandra, Chommeloux, Juliette, Paris, Meng, Nemlaghi, Safaa, Bay, Pierre, Demoule, Alexandre, Guidet, Bertrand, Constantin, Jean Michel, Fartoukh, Muriel, Dres, Martin, Nataf, Patrick, Franchineau, Guillaume, Le Fevre, Lucie, Raffoul, Richard, Alkhoder, Soleiman, Ghodbane, Walid, Pisani, Angelo, Braham, Wael, Bessem Gara, Ali, MORDANT, Pierre, CASTIER, Yves-Hervé, de MONTMOLLIN, Etienne, BOUADMA, Lila, TIMSIT, Jean-François, Langeron, Olivier, de Roux, Quentin, Alessandri, Claire, Arminot-Frémaux, Margot, Clariot, Simon, Dessalle, Thomas, Kudela, Agathe, Ly, André, Meffert, Arnaud, Skripkina, Elena, Fiore, Antonio, Radu, Costin, Dupuy-Montbrun, Eleonora, Latremouille, Christian, Mercier, Olaf, Deleuze, Philippe, STEPHAN, François, Duranteau, Jacques, Richard, Christian, Werner, Marie, Teboul, Jean-Louis, Monnet, Xavier, Debbagh, Hassan, Chapelier, Alain, De Wolf, Julien, Glorion, Matthieu, Pricopi, Ciprian, Cassiano, Francesco, Jacquemin, Sébastien, Tachon, Guillaume, Parquin, François, Zuber, Benjamin, Carriou, Alain, Mira, Jean-Paul, Charpentier, Julien, Pene, Frederic, Nguyen, Lee, Voicu, Sébastian, Deye, Nicolas, Malissin, Isabelle, Sutterlin, Laetitia, Naim, Giulia, Pépin-Lehalleur, Adrien, Mrad, Aymen, Ekhérian, Jean-Michel, Nguyen, Philippe, Sidéris, Georgios, Vodovar, Dominique, Grant, Caroline, Arcelli, Mattéo, Copie, Alban, Errabih, Zaccaria, Gonde, Antoine, Magalhaes, Adèle, Meurisse, Edouard, Nitenberg, Kiyoko, Perault, Arthur, Perrin, Lucile, Renaux, Maxime, Marqué, Sophie, Ensenyat-Martin, Luis, Delpierre, Eric, Duprey, Matthieu, da Silva, Daniel, Verdière, Bruno, Amour, Julien, Clément, Marina, Ollivier, Yves, Morichau-Beauchant, Tristan, Daviaud, Fabrice, Le Breton, Camille, Freita-Ramos, Santiago, Amouretti, Marc, Billiet, Pierre Antoine, Dao, Myriam, Dumont, Louis Marie, Federici, Laura, Gaborieau, Baptiste, Postel-Vinay, Pierre, Vuillard, Constance, Zucman, Noémie, Dreyfuss, Didier, Ricard, Jean Damien, Roux, Damien, Lebreton, Guillaume, Schmidt, Matthieu, Ponnaiah, Maharajah, Folliguet, Thierry, Para, Marylou, Guihaire, Julien, Lansac, Emmanuel, Sage, Edouard, Cholley, Bernard, Mégarbane, Bruno, Cronier, Pierrick, Zarka, Jonathan, Da Silva, Daniel, Besset, Sebastien, Lacombat, Igor, Mongardon, Nicolas, Cerf, Charles, Saiydoun, Gabriel, Sonneville, Romain, Chiche, Jean-Daniel, Longrois, Dan, Combes, Alain, and Leprince, Pascal

Published
2021
Full Text
View/download PDF

25. Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study

Author

Luyt, Charles-Edouard, Hekimian, Guillaume, Brechot, Nicolas, Pineton de Chambrun, Marc, Desnos, Cyrielle, Arzoine, Jeremy, Guerin, Emmanuelle, Schoell, Thibaut, Demondion, Pierre, Juvin, Charles, Nardonne, Nathalie, Marin, Sofica, D'Alessandro, Cossimo, Nguyen, Bao-Long, Quemeneur, Cyril, James, Arthur, Assefi, Mona, Lepere, Victoria, Savary, Guillaume, Gibelin, Aude, Turpin, Matthieu, Elabbadi, Alexandre, Berti, Enora, Vezinet, Corinne, Bonvallot, Harold, Delmotte, Pierre-Romain, De Sarcus, Martin, Du Fayet De La Tour, Charlotte, Abbas, Samia, Maury, Eric, Baudel, Jean-Luc, Lavillegrand, Jean-Remi, Ait Oufella, Hafid, Abdelkrim, Abdelmalek, Urbina, Thomas, Virolle, Sara, Deleris, Robin, Bonny, Vincent, Le Marec, Julien, Mayaux, Julien, Morawiec, Elise, Schmidt, Matthieu, Hajage, David, Lebreton, Guillaume, Monsel, Antoine, Voiriot, Guillaume, Levy, David, Baron, Elodie, Beurton, Alexandra, Chommeloux, Juliette, Meng, Paris, Nemlaghi, Safaa, Bay, Pierre, Leprince, Pascal, Demoule, Alexandre, Guidet, Bertrand, Constantin, Jean Michel, Fartoukh, Muriel, Dres, Martin, and Combes, Alain

Published
2020
Full Text
View/download PDF

28. Lung Ultrasound Score on Postoperative Day 1 Is Predictive of the Occurrence of Pulmonary Complications after Major Abdominal Surgery: A Multicenter Prospective Observational Study

Author

Boussier, Jeremy, primary, Lemasle, Aymeric, additional, Hantala, Nicolas, additional, Scatton, Olivier, additional, Vaillant, Jean-Christophe, additional, Paye, François, additional, Langeron, Olivier, additional, Lescot, Thomas, additional, Quesnel, Christophe, additional, Verdonk, Franck, additional, Eyraud, Daniel, additional, Sitbon, Alexandre, additional, Delorme, Louis, additional, and Monsel, Antoine, additional

Published
2023
Full Text
View/download PDF

31. Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial

Author

Sophie, Cayot, Thomas, Godet, Renaud, Guerin, Camille, Verlac, Russel, Chabanne, Bernard, Cosserant, Raiko, Blondonnet, Alexandre, Lautrette, Nathanael, Eisenmann, Laurent, Muller, Pablo, Massanet, Caroline, Boutin, Saber, Barbar, Claire, Roger, Fouad, Belafia, Moussa, Cisse, Marion, Monnin, Matthieu, Conseil, Julie, Carr, Audrey, De Jong, Auguste, Dargent, Pascal, Andreu, Thomas, Lebouvrier, Yoann, Launey, Antoine, Roquilly, Raphael, Cinotti, Anne-Charlotte, Tellier, Mathilde, Barbaz, Benjamin, Cohen, Edouard, Lemarche, Pierre-Marie, Bertrand, Charlotte, Arberlot, Laurent, Zieleskiewicz, Emmanuelle, Hammad, Garry, Duclos, Calypso, Mathie, Herve, Dupont, Benoit, Veber, Jean-Christophe, Orban, Hervé, Quintard, Thomas, Rimmele, Julien, Crozon-Clauzel, Marinne, Le Core, Fabien, Grelon, Mona, Assefi, Frank, Petitas, Jerome, Morel, Serge, Molliex, Nanadougmar, Hadanou, Constantin, Jean-Michel, Jabaudon, Matthieu, Lefrant, Jean-Yves, Jaber, Samir, Quenot, Jean-Pierre, Langeron, Olivier, Ferrandière, Martine, Grelon, Fabien, Seguin, Philippe, Ichai, Carole, Veber, Benoit, Souweine, Bertrand, Uberti, Thomas, Lasocki, Sigismond, Legay, François, Leone, Marc, Eisenmann, Nathanael, Dahyot-Fizelier, Claire, Dupont, Hervé, Asehnoune, Karim, Sossou, Achille, Chanques, Gérald, Muller, Laurent, Bazin, Jean-Etienne, Monsel, Antoine, Borao, Lucile, Garcier, Jean-Marc, Rouby, Jean-Jacques, Pereira, Bruno, and Futier, Emmanuel

Published
2019
Full Text
View/download PDF

32. Ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: understanding nebulization of aminoglycosides and colistin

Author

Rouby, J. J., Sole-Lleonart, C., Rello, J., Monsel, Antoine, Constantin, Jean-Michel, Bouglé, Adrien, and Blot, Stijn

Subjects
Pfizer Inc., Bayer HealthCare AG, Bacterial pneumonia, Drug resistance in microorganisms, Pneumonia, Antibacterial agents, Medical colleges, Aminoglycosides, Gram-negative bacteria, Pharmaceutical industry, Health care industry
Abstract

Author(s): J. J. Rouby [sup.1], C. Sole-Lleonart [sup.2] [sup.3], J. Rello [sup.4] [sup.5] [sup.6], Antoine Monsel, Jean-Michel Constantin, Adrien Bouglé, Stijn Blot, Garyphalia Poulakou, Konstantinos Pontikis, Anna Kyriakoudi, Antonia Koutsoukou, [...]

Published
2020
Full Text
View/download PDF

33. Guidelines for Perioperative Care for Liver Transplantation: Enhanced Recovery After Surgery (ERAS) Recommendations

Author

Brustia, Raffaele, Monsel, Antoine, Skurzak, Stefano, Schiffer, Eduardo, Carrier, François Martin, Patrono, Damiano, Kaba, Abdourahamane, Detry, Olivier, Malbouisson, Luiz, Andraus, Wellington, Vandenbroucke-Menu, Franck, Biancofiore, Gianni, Kaido, Toshimi, Compagnon, Philippe, Uemoto, Shinji, Rodriguez Laiz, Gonzalo, De Boer, Marieke, Orloff, Susan, Melgar, Paola, Buis, Carlijn, Zeillemaker-Hoekstra, Miriam, Usher, Helen, Reyntjens, Koen, Baird, Emily, Demartines, Nicolas, Wigmore, Stephen, and Scatton, Olivier

Published
2022
Full Text
View/download PDF

34. Therapeutic Effects of Human Mesenchymal Stem Cell–derived Microvesicles in Severe Pneumonia in Mice

Author

Monsel, Antoine, Zhu, Ying-gang, Gennai, Stephane, Hao, Qi, Hu, Shuling, Rouby, Jean-Jacques, Rosenzwajg, Michelle, Matthay, Michael A, and Lee, Jae W

Subjects
Infectious Diseases, Lung, Stem Cell Research, Pneumonia, Pneumonia & Influenza, Stem Cell Research - Nonembryonic - Human, Regenerative Medicine, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Acute Lung Injury, Animals, Cell-Derived Microparticles, Cells, Cultured, Disease Models, Animal, Humans, Male, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells, Mice, Mice, Inbred C57BL, Pneumonia, Bacterial, acute respiratory distress syndrome, bacterial pneumonia, mesenchymal stem cells, microvesicles, Medical and Health Sciences, Respiratory System
Abstract

RationaleMicrovesicles (MVs) are anuclear fragments of cells released from the endosomal compartment or shed from surface membranes. We and other investigators demonstrated that MVs released by mesenchymal stem cells (MSCs) were as effective as the cells themselves in inflammatory injuries, such as after endotoxin-induced acute lung injury. However, the therapeutic effects of MVs in an infectious model of acute lung injury remain unknown.ObjectivesWe investigated the effects of human MSC MVs on lung inflammation, protein permeability, bacterial clearance, and survival after severe bacterial pneumonia.MethodsWe tested the effects of MVs derived from human MSCs on Escherichia coli pneumonia in mice. We also studied the interactions between MVs and human monocytes and human alveolar epithelial type 2 cells.Measurements and main resultsAdministration of MVs derived from human MSCs improved survival in part through keratinocyte growth factor secretion and decreased the influx of inflammatory cells, cytokines, protein, and bacteria in mice injured with bacterial pneumonia. In primary cultures of human monocytes or alveolar type 2 cells, the uptake of MVs was mediated by CD44 receptors, which were essential for the therapeutic effects. MVs enhanced monocyte phagocytosis of bacteria while decreasing inflammatory cytokine secretion and increased intracellular ATP levels in injured alveolar epithelial type 2 cells. Prestimulation of MSCs with a toll-like receptor 3 agonist further enhanced the therapeutic effects of the released MVs.ConclusionsMVs derived from human MSCs were as effective as the parent stem cells in severe bacterial pneumonia.

Published
2015

35. Study of Bone Marrow and Embryonic Stem Cell‐Derived Human Mesenchymal Stem Cells for Treatment of Escherichia coli Endotoxin‐Induced Acute Lung Injury in Mice

Author

Hao, Qi, Zhu, Ying-gang, Monsel, Antoine, Gennai, Stephane, Lee, Travis, Xu, Fengyun, and Lee, Jae-Woo

Subjects
Regenerative Medicine, Stem Cell Research - Embryonic - Non-Human, Lung, Acute Respiratory Distress Syndrome, Rare Diseases, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research - Nonembryonic - Human, Development of treatments and therapeutic interventions, 2.1 Biological and endogenous factors, Aetiology, 5.2 Cellular and gene therapies, Respiratory, Acute lung injury, Embryonic stem cells, Matrix metallopeptidase, Mesenchymal stem cell, Biochemistry and Cell Biology, Medical Biotechnology, Clinical Sciences
Abstract

Unlabelled: Mesenchymal stem cells (MSCs) can be derived from multiple tissue sources. However, the optimal source of MSCs for cell-based therapy for acute lung injury (ALI) is unclear. In the present experiments, we studied bone marrow (BM)-derived and embryonic stem cell-derived human MSC (ES-MSCs) as a therapeutic agent in Escherichia coli endotoxin-induced ALI in mice. We hypothesized that ES-MSCs would be more potent than BM-MSCs owing to its more primitive source of origin. ALI was induced by the intratracheal instillation of endotoxin at 4 mg/kg into 10-12-week-old C57BL/6 mice with or without BM-MSCs, ES-MSCs, or normal human lung fibroblasts as a cellular control. Compared with the endotoxin-injured mice at 48 hours, the administration of ES-MSCs provided results similar to those of BM-MSCs, significantly reducing the influx of white blood cells and neutrophils and decreasing the secretion of the inflammatory cytokines, macrophage inflammatory protein-2 and tumor necrosis factor-α, in the injured alveolus. BM-MSCs also reduced extravascular lung water, a measure of pulmonary edema, by 60% and the total protein levels, a measure of lung permeability, by 66%. However, surprisingly, ES-MSCs did not have these protective effects, which was partially explained by the increased secretion of matrix metallopeptidase 9 by ES-MSCs, an enzyme known to increase lung protein permeability. In conclusion, both BM-MSCs and ES-MSCs markedly decreased endotoxin-induced inflammation. However, ES-MSCs did not show any beneficial effect on reducing pulmonary edema and lung protein permeability compared with BM-MSCs, suggesting that not all MSCs behave in a similar fashion. Our results highlight the need perhaps for a disease-specific potency assay for MSCs.SignificanceTo determine the optimal source of mesenchymal stem cells (MSCs) for cell-based therapy for acute lung injury, bone marrow (BM)- and embryonic stem cell-derived human MSC (ES-MSCs) were compared as therapeutic agents for Escherichia coli endotoxin-induced lung injury in mice. ES-MSCs behaved similarly to BM-MSCs by markedly decreasing the inflammatory response induced by endotoxin. However, unlike BM-MSCs, ES-MSCs provided no protective effects against increasing lung water and protein permeability, in part because of an increase in expression of matrix metallopeptidase 9 by ES-MSCs. In patients with acute respiratory distress syndrome, impaired alveolar fluid clearance (i.e., no resolution of pulmonary edema fluid) has been associated with higher mortality rates. Although ES-MSCs might ultimately be found to have properties superior to those of BM-MSCs, such as for immunomodulation, these results highlight the need for a disease-specific potency assay for stem cell-based therapy.

Published
2015

36. Cell-based Therapy for Acute Organ Injury

Author

Monsel, Antoine, Zhu, Ying-gang, Gennai, Stephane, Hao, Qi, Liu, Jia, and Lee, Jae W

Subjects
Biotechnology, Stem Cell Research, Transplantation, Physical Injury - Accidents and Adverse Effects, Regenerative Medicine, Clinical Research, Development of treatments and therapeutic interventions, 5.2 Cellular and gene therapies, Critical Illness, Humans, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells, Multiple Organ Failure, Multiple Trauma, Clinical Sciences, Anesthesiology
Abstract

Critically ill patients often suffer from multiple organ failures involving lung, kidney, liver, or brain. Genomic, proteomic, and metabolomic approaches highlight common injury mechanisms leading to acute organ failure. This underlines the need to focus on therapeutic strategies affecting multiple injury pathways. The use of adult stem cells such as mesenchymal stem or stromal cells (MSC) may represent a promising new therapeutic approach as increasing evidence shows that MSC can exert protective effects following injury through the release of promitotic, antiapoptotic, antiinflammatory, and immunomodulatory soluble factors. Furthermore, they can mitigate metabolomic and oxidative stress imbalance. In this work, the authors review the biological capabilities of MSC and the results of clinical trials using MSC as therapy in acute organ injuries. Although preliminary results are encouraging, more studies concerning safety and efficacy of MSC therapy are needed to determine their optimal clinical use. (ANESTHESIOLOGY 2014; 121:1099-121).

Published
2014

37. Human Mesenchymal Stem Cell Microvesicles for Treatment of Escherichia coli Endotoxin‐Induced Acute Lung Injury in Mice

Author

Zhu, Ying‐gang, Feng, Xiao‐mei, Abbott, Jason, Fang, Xiao‐hui, Hao, Qi, Monsel, Antoine, Qu, Jie‐ming, Matthay, Michael A, and Lee, Jae W

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Lung, Stem Cell Research - Nonembryonic - Human, Rare Diseases, Acute Respiratory Distress Syndrome, Regenerative Medicine, Biotechnology, Stem Cell Research, Aetiology, 2.1 Biological and endogenous factors, Respiratory, Acute Lung Injury, Animals, Cell-Derived Microparticles, Endotoxins, Escherichia coli, Humans, Lipopolysaccharides, Male, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells, Mice, Mice, Inbred C57BL, Microscopy, Electron, Acute lung injury, Keratinocyte growth factor, Lipopolysaccharide, Mesenchymal stem cell, Microvesicles, Biological Sciences, Technology, Medical and Health Sciences, Immunology, Biological sciences, Biomedical and clinical sciences
Abstract

We previously found that human mesenchymal stem cells (MSC) or its conditioned medium restored lung protein permeability and reduced alveolar inflammation following Escherichia coli endotoxin-induced acute lung injury (ALI) in an ex vivo perfused human lung in part through the secretion of soluble factors such as keratinocyte growth factor (KGF). Recently, MSC were found to release microvesicles (MVs) that were biologically active because of the presence of mRNA or miRNA with reparative properties. MVs are circular fragments of membrane released from the endosomal compartment as exosomes or shed from the surface membranes. These studies were designed to determine if MVs released by human bone marrow derived MSCs would be effective in restoring lung protein permeability and reducing inflammation in E. coli endotoxin-induced ALI in C57BL/6 mice. The intratracheal instillation of MVs improved several indices of ALI at 48 hours. Compared to endotoxin-injured mice, MVs reduced extravascular lung water by 43% and reduced total protein levels in the bronchoalveolar lavage (BAL) fluid by 35%, demonstrating a reduction in pulmonary edema and lung protein permeability. MVs also reduced the influx of neutrophils and macrophage inflammatory protein-2 levels in the BAL fluid by 73% and 49%, respectively, demonstrating a reduction in inflammation. KGF siRNA-pretreatment of MSC partially eliminated the therapeutic effects of MVs released by MSCs, suggesting that KGF protein expression was important for the underlying mechanism. In summary, human MSC-derived MVs were therapeutically effective following E. coli endotoxin-induced ALI in mice in part through the expression of KGF mRNA in the injured alveolus.

Published
2014

39. P10 Characterization of Metabolomic Fingerprints in Patients With Hepatic Encephalopathy and Fulminant Hepatitis or Acute Decompensation of Cirrhosis, Before and After Liver Transplantation

Author

Pinceaux, Kieran, primary, Castelli, Florence, additional, Fenaille, François, additional, Junot, Christophe, additional, Mouri, Sarah, additional, Coirier, Valentin, additional, Giguet, Baptiste, additional, Camus, Christophe, additional, Tadié, Jean-Marc, additional, Bardou-Jacquet, Édouard, additional, Houssel-Debry, Pauline, additional, Sulpice, Laurent, additional, Monsel, Antoine, additional, Sitbon, Alexandre, additional, Delmotte, Pierre-Romain, additional, Thabut, Dominique, additional, Weiss, Nicolas, additional, and Rudler, Marika, additional

Published
2023
Full Text
View/download PDF

41. Pneumonies associées aux soins de réanimation

Author

Leone, Marc, Bouadma, Lila, Bouhemad, Belaïd, Brissaud, Olivier, Dauger, Stéphane, Gibot, Sébastien, Hraiech, Sami, Jung, Boris, Kipnis, Eric, Launey, Yoann, Luyt, Charles-Edouard, Margetis, Dimitri, Michel, Fabrice, Mokart, Djamel, Montravers, Philippe, Monsel, Antoine, Nseir, Saad, Pugin, Jérôme, Roquilly, Antoine, Velly, Lionel, Zahar, Jean-Ralph, Bruyère, Rémi, and Chanques, Gérald

Published
2018
Full Text
View/download PDF

43. Hospital-acquired pneumonia in ICU

Author

Leone, Marc, Bouadma, Lila, Bouhemad, Bélaïd, Brissaud, Olivier, Dauger, Stéphane, Gibot, Sébastien, Hraiech, Sami, Jung, Boris, Kipnis, Eric, Launey, Yoann, Luyt, Charles-Edouard, Margetis, Dimitri, Michel, Fabrice, Mokart, Djamel, Montravers, Philippe, Monsel, Antoine, Nseir, Saad, Pugin, Jérôme, Roquilly, Antoine, Velly, Lionel, Zahar, Jean-Ralph, Bruyère, Rémi, and Chanques, Gérald

Published
2018
Full Text
View/download PDF

44. Lung Ultrasound in Emergency and Critically Ill Patients: Number of Supervised Exams to Reach Basic Competence

Author

Arbelot, Charlotte, Dexheimer Neto, Felippe Leopoldo, Gao, Yuzhi, Brisson, Hélène, Chunyao, Wang, Lv, Jie, Valente Barbas, Carmen Silvia, Perbet, Sébastien, Prior Caltabellotta, Fabiola, Gay, Frédérick, Deransy, Romain, Lima, Emidio J. S., Cebey, Andres, Monsel, Antoine, Neves, Julio, Zhang, Mao, Bin, Du, An, Youzhong, Malbouisson, Luis, Salluh, Jorge, Constantin, Jean-Michel, Rouby, Jean-Jacques, Biestro, Alberto, Vezinet, Corinne, Garçon, Pierre, El Hadj Kacem, Nabil, Lemesle, Denis, Lucena, Bruno, de Paula Pinto Schettino, Guilherme, Cristovao, Davi, de Tarso Roth Dalcin, Paulo, and Carmona, Maria José Carvalho

Published
2020
Full Text
View/download PDF

45. Adult stem cells for acute lung injury

Author

Zhu, Ying‐Gang, Hao, Qi, Monsel, Antoine, Feng, Xiao‐Mei, and Lee, Jae‐Woo

Subjects
Rare Diseases, Stem Cell Research, Stem Cell Research - Nonembryonic - Human, Acute Respiratory Distress Syndrome, Pneumonia, Stem Cell Research - Nonembryonic - Non-Human, Infectious Diseases, Regenerative Medicine, Lung, 2.1 Biological and endogenous factors, 5.2 Cellular and gene therapies, Development of treatments and therapeutic interventions, Aetiology, Respiratory, Inflammatory and immune system, Acute Lung Injury, Adult Stem Cells, Animals, Disease Models, Animal, Humans, Mesenchymal Stem Cell Transplantation, acute lung injury, cell-based therapy, endothelial progenitor cell, mesenchymal stem cell, paracrine soluble factor, Medical and Health Sciences, Respiratory System
Abstract

Acute lung injury (ALI) or acute respiratory distress syndrome remains a major cause of morbidity and mortality in hospitalized patients. The pathophysiology of ALI involves complex interactions between the inciting event, such as pneumonia, sepsis or aspiration, and the host immune response resulting in lung protein permeability, impaired resolution of pulmonary oedema, an intense inflammatory response in the injured alveolus and hypoxemia. In multiple preclinical studies, adult stem cells have been shown to be therapeutic due to both the ability to mitigate injury and inflammation through paracrine mechanisms and perhaps to regenerate tissue by virtue of their multi-potency. These characteristics have stimulated intensive research efforts to explore the possibility of using stem or progenitor cells for the treatment of lung injury. A variety of stem or progenitor cells have been isolated, characterized and tested experimentally in preclinical animal models of ALI. However, questions remain concerning the optimal dose, route and the adult stem or progenitor cell to use. Here, the current mechanisms underlying the therapeutic effect of stem cells in ALI as well as the questions that will arise as clinical trials for ALI are planned are reviewed.

Published
2013

50. Subcostal transversus abdominis plane block for postoperative analgesia in liver transplant recipients: a before-and-after study

Author

Assefi, Mona, primary, Trillaud, Emma, additional, Vezinet, Corinne, additional, Duceau, Baptiste, additional, Baron, Elodie, additional, Pons, Stephanie, additional, Clavieras, Noemie, additional, Quemeneur, Cyril, additional, Selves, Agathe, additional, Scatton, Olivier, additional, Monsel, Antoine, additional, and Constantin, Jean-Michel, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results