1. Effects of off-pump versus on-pump coronary artery bypass grafting: Apoptosis, ınflammation, and oxidative stress
- Author
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Isik Senkaya Signak, Murat Biçer, Zehra Serdar, Tunay Şentürk, Arzu Yilmaztepe Oral, Engin Ulukaya, Murat Yanar, Ahmet Tütüncü, Uludağ Üniversitesi/Tıp Fakültesi/Kalp ve Damar Cerrahisi Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı., Biçer, Murat, Şentürk, Tunay, Yanar, Murat, Tütüncü, Ahmet S., Oral, Arzu Yılmaztepe, Ulukaya, Engin, Serdar, Zehra, Şenkaya, Işık, ABC-2231-2020, C-1517-2017, AAW-1039-2020, AAH-6200-2021, K-5792-2018, and A-5841-2017
- Subjects
Serum ,Male ,Bypass grafting ,Cardiac & cardiovascular systems ,Blood sampling ,Unclassified drug ,On pump coronary surgery ,Coronary artery bypass ,Apoptosis ,medicine.disease_cause ,Procedures ,Coronary artery disease ,Epithelium cell ,law.invention ,chemistry.chemical_compound ,Plasma ,Randomized controlled trial ,law ,Coronary artery bypass graft ,Operations ,Antibody blood level ,Protein blood level ,Treatment outcome ,Middle aged ,Priority journal ,C reactive protein ,Malonaldehyde ,Neurological complication ,Off Pump Coronary Surgery ,Coronary Artery Bypass Graft ,Bypass Surgery ,Cytokeratin-18 ,Malondialdehyde ,Coronary artery surgery ,Off pump coronary surgery ,surgical procedures, operative ,medicine.anatomical_structure ,Monoclonal antibody m30 ,Anesthesia ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Artery ,Human ,Adult ,Monoclonal antibody ,medicine.medical_specialty ,Immunology ,Inflammation ,Major clinical study ,Monoclonal antibody m65 ,Article ,Internal medicine ,medicine ,Humans ,Mortality ,business.industry ,Endothelial apoptosis ,medicine.disease ,Mediastinitis ,Biological marker ,Cardiovascular system & cardiology ,chemistry ,Oxidative stress ,Cell apoptosis ,Surgery ,business ,Reactive oxygen species ,Controlled study ,Reactive oxygen metabolite ,Endothelium cell - Abstract
Background: It has been suggested that off-pump coronaryartery bypass grafting (CABG) surgery reduces myocardialischemia-reperfusion injury, postoperative systemicinflammatory response, and oxidative stress. The aim of thisstudy was to measure serum malondialdehyde (MDA), highsensitivityC-reactive protein (hs-CRP), M30, and M65 levelsand to investigate the relationship between M30 levels andoxidative stress and inflammation in patients undergoing onandoff-pump CABG surgery.Methods: Fifty patients were randomly assigned to onpumpor off-pump CABG surgery (25 patients off-pump and25 on-pump CABG surgery), and blood samples were collectedprior to surgery, and 30 minutes, 60 minutes, 6 hours,and 24 hours after CABG surgery.Results: Compared to the on-pump group, serum MDAlevels at 30 minutes, 60 minutes, 6 hours, and 24 hours afterthe CABG surgery were significantly lower in the off-pumpgroup (P = .001, P = .001, P = .001, and P = .001, respectively).Serum M30 levels were found to be elevated in both groups,returning to baseline at 24 hours. When compared to baseline,the hs-CRP level reached its peak at 24 hours at 13.28 ±5.32 mg/dL in the on-pump group, and 15.44 ± 4.02 mg/dLin the off-pump group.Conclusion: CABG surgery is associated with an increasein inflammatory markers and serum M30 levels, indicatingepithelial/endothelial apoptosis in the early period.
- Published
- 2014