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7 results on '"Monirizad, Mahsa"'

2. Amphotericin B-loaded natural latex dressing for treating Candida albicans wound infections using Galleria mellonella model

Author

Herculano, Rondinelli Donizetti, dos Reis, Camila Eugênia, de Souza, Silvia Maria Batista, Pegorin Brasil, Giovana Sant'Ana, Scontri, Mateus, Kawakita, Satoru, Carvalho, Bruna Gregatti, Bebber, Camila Calderan, Su, Yanjin, de Sousa Abreu, Ana Paula, Mecwan, Marvin M, Mandal, Kalpana, Fusco Almeida, Ana Marisa, Mendes Giannini, Maria José Soares, Guerra, Nayrim Brizuela, Mussagy, Cassamo Ussemane, Bosculo, Maria Rachel Melo, Gemeinder, José Lúcio Pádua, de Almeida, Breno Fernando Martins, Floriano, Juliana Ferreira, Farhadi, Neda, Monirizad, Mahsa, Khorsandi, Danial, Nguyen, Huu Tuan, Gomez, Alejandro, Tirpáková, Zuzana, Peirsman, Arne, da Silva Sasaki, Josana Carla, He, Siqi, Forster, Samuel, Burd, Betina Sayeg, Dokmeci, Mehmet Remzi, Terra-Garcia, Maíra, Junqueira, Juliana Campos, de Mendonça, Ricardo José, Cardoso, Marcos Roberto, dos Santos, Lindomar Soares, Silva, Gláucio Ribeiro, Barros, Natan Roberto, Jucaud, Vadim, and Li, Bingbing

Published
2024
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4. Drug‐Eluting Shear‐Thinning Hydrogel for the Delivery of Chemo‐ and Immunotherapeutic Agents for the Treatment of Hepatocellular Carcinoma

Author

Falcone, Natashya, primary, Ermis, Menekse, additional, Gangrade, Ankit, additional, Choroomi, Auveen, additional, Young, Patric, additional, Mathes, Tess G., additional, Monirizad, Mahsa, additional, Zehtabi, Fatemeh, additional, Mecwan, Marvin, additional, Rodriguez, Marco, additional, Zhu, Yangzhi, additional, Byun, Youngjoo, additional, Khademhosseini, Ali, additional, de Barros, Natan Roberto, additional, and Kim, Han‐Jun, additional

Published
2023
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5. Drug‐Eluting Shear‐Thinning Hydrogel for the Delivery of Chemo‐ and Immunotherapeutic Agents for the Treatment of Hepatocellular Carcinoma.

Author

Falcone, Natashya, Ermis, Menekse, Gangrade, Ankit, Choroomi, Auveen, Young, Patric, Mathes, Tess G., Monirizad, Mahsa, Zehtabi, Fatemeh, Mecwan, Marvin, Rodriguez, Marco, Zhu, Yangzhi, Byun, Youngjoo, Khademhosseini, Ali, de Barros, Natan Roberto, and Kim, Han‐Jun

Subjects
HEPATOCELLULAR carcinoma, IMMUNE checkpoint inhibitors, CHEMOEMBOLIZATION, LIVER cancer, CANCER treatment, POLYMERSOMES
Abstract

Hepatocellular carcinoma (HCC) is a malignant and deadly form of liver cancer with limited treatment options. Transcatheter arterial chemoembolization, a procedure that delivers embolic and chemotherapeutic agents through blood vessels, is a promising cancer treatment strategy. However, it still faces limitations, such as inefficient agent delivery and the inability to address tumor‐induced immunosuppression. Here, a drug‐eluting shear‐thinning hydrogel (DESTH) loaded with chemotherapeutic and immunotherapeutic agents in nanocomposite hydrogels composed of gelatin and nanoclays is presented as a therapeutic strategy for a catheter‐based endovascular anticancer approach. DESTH is manually deliverable using a conventional needle and catheter. In addition, drug release studies show a sustained and pH‐dependent co‐delivery of the chemotherapy doxorubicin (acidic pH) and the immune‐checkpoint inhibitor aPD‐1 (neutral pH). In a mouse liver tumor model, the DESTH‐based chemo/immunotherapy combination has the highest survival rate and smallest residual tumor size. Finally, immunofluorescence analysis confirms that DESTH application enhances cell death and increases intratumoral infiltration of cytotoxic T‐cells. In conclusion, the results show that DESTH, which enables efficient ischemic tumor cell death and effective co‐delivery of chemo‐ and immunotherapeutic agents, may have the potential to be an effective therapeutic modality in the treatment of HCC. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Peptide Hydrogels as Immunomaterials and Their Use in Cancer Immunotherapy Delivery

Author

Falcone, Natashya, primary, Ermis, Menekse, additional, Tamay, Dilara Goksu, additional, Mecwan, Marvin, additional, Monirizad, Mahsa, additional, Mathes, Tess Grett, additional, Jucaud, Vadim, additional, Choroomi, Auveen, additional, Barros, Natan, additional, Zhu, Yangzhi, additional, Vrana, Nihal Engin, additional, Kraatz, Heinz‐Bernhard, additional, Kim, Han‐Jun, additional, and Khademhosseini, Ali, additional

Published
2023
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