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Background: Pathologic examination of Acute Generalized Exanthematous Pustulosis (AGEP) and Pustular Psoriasis (PP) are similar. We encountered many patients with PP or AGEP who cannot be distinguished clinically, pathologically and based on disease course from each so we designed a comprehensive interpersonal histopathologic overview of these patients' samples. Method: Histopathological data of 16 patients over 3.5 years were analyzed. Four pathologists separately reviewed specimens based on eighteen criteria (9 Epidermal and 9 Dermal). Severity score for each criterion was considered as to be (0 to 3+). We compared the final pathologic diagnosis with primary one. Results: Neutrophilic and lymphocytic infiltration in dermis were seen in all cases of AGEP while intraepithelial pustules. Subcorneal and intraepithelial pustules, spongiosis, neutrophilic exocytosis, neutrophilic and lymphocytic infiltration in dermis were observed in all cases of PP. The most severe neutrophilic inflammation; acanthosis and neutrophilic or lymphocytic infiltration were seen in PP. The authors of this study have been reported generalized pustular clinical presentations of patients have been taken HCQ, and in the recent pandemic it is also one of the concerns that many studies have been focused (....). Conclusion: When primary histopathologic report is AGEP/PP overlap, clinical judgment is the best way to manage and it is more probable that the final diagnosis being PP. When only AGEP or PP is histopathologic diagnostic report, it is usually enough to make final diagnosis and appropriate management. Key words: hydroxychloroquine, HCQ, generalized pustular cutaneous eruption, Pustular Psoriasis (PP), Acute Generalized Exanthematous Pustulosism, AGEP, Histopathological overview, pathology, review

Background: The incidence of cutaneous malignant melanoma (CMM) has increased continuously during recent decades among many populations of the world. Cutaneous Malignant Melanoma is a malignancy with a demographic and ethnic disparity located in the skin and mucous membranous. The objective of this study is to determine Cutaneous Melanoma (CM) characteristics in Iran. Methods: This is a retrospective cross sectional study. We used data from Razi Hospital, Tehran University Melanoma Cancer Registry. The cases included in this study met the following criteria: primary CM, in situ or invasive, diagnosed in the recent past ten years. We have evaluated prognostic factors in addition to basic demographic data. Result: A total of 193 melanomas (99 males (51.3%) and 94 females (48.7%)) were included. The mean age was 58.3±15.8years. The most frequent location for melanoma was lower extremity (75 patients, 38.9%). The most frequent subtype for melanoma based on histopathology was the Acral Lentiginous Melanoma (ALM) (74 patients, 38.3%). There was statistically significant difference between histological subtypes of melanoma and Breslow thickness (p˂ 0.00 1). Conclusion: Present study showed risk factors such as age and pre-existing nevus are important factors in CMM incidence in Iran. Early detection of melanoma is a key factor in improving patients’ survival. Keywords: Cutaneous Melanoma, Malignant Melanoma, Cancer, Epidemiology, Histopathology, Immunohistochemistry, Histology, IHC, Original study, Skin cancer

Scars are among the most prevalent referral cases of dermatology clinics, including atrophic, hypertrophic, or keloidal scars. Approach to scar usually needs a holistic trend, attention to individualized characteristics, and combination therapy. Scars usually need multiple sessions of therapy and the use of combination therapeutic approaches to reach the most acceptable outcomes by safe modalities. Studies on scars are always one of the most important fields of research in medicine, especially in dermatology. For writing this review study, we searched all the databases to find the most relevant and the newest studies related to our topic, because based on expert opinion, this topic may be really practical and interesting for dermatologists and all physicians of various specialties or subspecialties who manage and treat various kinds of scars, including hypertrophic scars and keloids. Based on our results, we concluded that different procedures, which basically use needling, lasers, especially pulsed dye laser (PDL) and carbon dioxide (CO