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Your search keyword '"Monika Tomczuk-Ostapczuk"' showing total 3 results
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3 results on '"Monika Tomczuk-Ostapczuk"'

1. Autoimmune sclerosing cholangitis might be triggered by SARS-CoV-2 infection in a child – a case report

Author

Katarzyna Zdanowicz, Anna Bobrus-Chociej, Anna Kopiczko, Mirosława Uścinowicz, Monika Tomczuk-Ostapczuk, Jacek Janica, Joanna Łotowska, Irena Białokoz-Kalinowska, and Dariusz Lebensztejn

Subjects
children, covid-19, autoimmune hepatitis/primary sclerosing cholangitis overlap syndrome., Medicine
Abstract

The spectrum of liver involvement during coronavirus disease 2019 (COVID-19) is broad and mainly includes elevated liver enzymes and cholestasis. Severe acute respiratory syndrome corona- virus-2 (SARS-CoV-2) infection most often leads to a transient moderate increase in liver enzymes that is not accompanied by disturbances in the synthetic function of the liver. However, there is increasing evidence that SARS-CoV-2 infection is associated with the development of autoimmune disorders. The pathogenesis of autoimmune hepatobiliary diseases is not fully understood, taking into account genetic and environmental factors such as viral infections. We present a pediatric case of autoimmune sclerosing cholangitis (ASC), which was diagnosed 2 months after SARS-CoV-2 infection. To the best of our knowledge, ASC potentially triggered by COVID-19 has not been reported in pediatric patients. Further studies are needed to describe the clinical impact of the development of autoimmune liver diseases potentially associated with SARS-CoV-2 infection in pediatric patients. Our observations indicate that children with liver injury potentially caused by COVID-19 require long-term monitoring of liver function parameters.

Published
2022
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2. Vitamin D Deficiency and Carotid Media-Intima Thickness in Childhood Cancer Survivors

Author

Eryk Latoch, Kacper Kozłowski, Katarzyna Konończuk, Beata Żelazowska-Rutkowska, Monika Tomczuk-Ostapczuk, Maryna Krawczuk-Rybak, and Katarzyna Muszyńska-Rosłan

Subjects
atherosclerosis, cancer, CCS, children, late effects, Nutrition. Foods and food supply, TX341-641
Abstract

Childhood cancer survivors (CCS) are predisposed to developing numerous late effects of anticancer treatment later in life. The existing literature suggests that vitamin D deficiency (VDD) may influence cardiovascular abnormalities and metabolic diseases. The objectives of this study were to investigate the prevalence of VDD among childhood cancer survivors and examine the association of vitamin D deficiency and carotid intima-media thickness (IMT). The study comprised 111 childhood cancer survivors (62 males, 49 females) with a median follow-up time of 6.14 years. Vitamin D status was determined by measuring serum 25(OH)D levels using the automatic immunoenzymatic method. Ultrasonography of the common carotid artery (CCA), the carotid bulb, and the proximal part of the internal carotid artery (ICA) was conducted. Vitamin D deficiency (

Published
2023
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3. Carotid intima-media thickness in young survivors of childhood cancer

Author

Anna Panasiuk, Monika Tomczuk-Ostapczuk, Elzbieta Goscik, and Maryna Krawczuk-Rybak

Subjects
Carotid Artery Diseases, Male, medicine.medical_specialty, Adolescent, 030204 cardiovascular system & hematology, Carotid Intima-Media Thickness, 03 medical and health sciences, 0302 clinical medicine, medicine.artery, Carotid artery disease, Neoplasms, medicine, Humans, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, Common carotid artery, Survivors, Child, Subclinical infection, business.industry, Cancer, medicine.disease, Blood pressure, Oncology, Intima-media thickness, 030220 oncology & carcinogenesis, Child, Preschool, cardiovascular system, Female, Radiology, Internal carotid artery, business, Body mass index, Follow-Up Studies
Abstract

Introduction Radiotherapy (RT) and some chemotherapy regimens are known risk factors predisposing to the development of premature arterial disease. Vascular ultrasound measurement of carotid intima-media thickness (IMT) is a non-invasive technique, useful to detect early subclinical symptoms of atherosclerosis that can appear in the paediatric population. We analysed the influence of chemotherapy and moderate doses of head or neck irradiation in childhood cancer survivors on the possibility of premature carotid artery disease. Methods Ultrasound measurements of the intima-media thickness (IMT) in the common carotid artery (CCA), bulb and internal carotid artery (ICA) were performed in 74 young cancer survivors and in 48 age- and sex-matched controls. Results In the whole study group, we observed higher IMT in all positions as compared with the control, except for comparable thickness in the CCA (bilaterally). We failed to find any differences in IMT between irradiated and non-irradiated females. In irradiated males, all IMT measurements on the right side were higher than in non-irradiated patients. There was no effect of body mass index, blood pressure, serum cholesterol, triglycerides, fibrinogen and thyroid hormones on IMT. In the irradiated group, a positive correlation was observed between IMT in the right bulb and the post-radiation time. Conclusions Anticancer treatment during childhood, especially including irradiation to the mediastinum, head or neck, affects the IMT, particularly in males. This suggests a possible role of irradiation in the premature development of carotid artery disease.

Published
2016

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