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2. EFFECT OF FOUR UNANI FORMULATIONS ON PHYTOCHEMICAL, ANTIOXIDANT AND ANTI-CANCEROUS ANALYSIS OF AQUEOUS, HYDROETHANOL AND METHANOL EXTRACTS.

Author

Ghali, Shravan Kumar, Moni, Bottu Heleena, Tabrez, Shaik, Rafeeqi, Towseef Amin, Ahmad, Tasleem, Waheed, Mohammed Abdul, Chakraborty, Alokananda, and Kazmi, Munawwar Husain

Subjects
ARAB medicine, CANCER treatment, PHYTOCHEMICALS, BREAST cancer, ANTIOXIDANTS
Abstract

Unani has a tremendous wealth of medically therapeutic ingredients, which provide an incredible potential as a stand-alone and/or adjuvant treatment like cancer for a range of conditions. Globally, with a significant proportion of breast cancer, the rate of cancer and cancer-related deaths is increasingly growing. Many existing breast cancer treatment methods are usually ineffective, but time-tested Unani drugs can be scrutinized for their new properties, including anti-cancer activity. In this attempt, we have studied the phytochemical, anti-oxidant and anti-cancer activity of human breast adenocarcinoma called MCF-7 cell line, which was obtained from NCCS Pune and performed experiments for may be the first time. MCF-7 cell line was treated with four separate Unani formulation (UF) were made into three solvents like Aqueous, Hydroethanol and Methanol extracts. Extracts of UF3 and UF4 have shown the high antioxidant efficiency of three separate tests like DPPH, ABTS and FRAP. Anticancer activity of various Unani formulation extracts at various doses has been assessed and the importance of IC50 has been determined. Hydro-ethanolic UF1, UF3 and UF5 extracts demonstrate better anti-cancer properties (IC50 < 100 μg ml-1), accompanied by aqueous UF4 extracts; other extracts have high IC50 values (i.e. > 1,000 μg ml-1). These Unani system of medicine have the ability to create new breast cancer therapies. Additional verification of the medicinal value should be conducted in so many other cell lines and eventually in preclinical models. [ABSTRACT FROM AUTHOR]

Published
2021

3. Polyunsaturated Fatty Acids Attenuate Diet Induced Obesity and Insulin Resistance, Modulating Mitochondrial Respiratory Uncoupling in Rat Skeletal Muscle

Author

Cavaliere, Gina, primary, Trinchese, Giovanna, additional, Bergamo, Paolo, additional, De Filippo, Chiara, additional, Mattace Raso, Giuseppina, additional, Gifuni, Giorgio, additional, Putti, Rosalba, additional, Moni, Bottu Heleena, additional, Canani, Roberto Berni, additional, Meli, Rosaria, additional, and Mollica, Maria Pina, additional

Published
2016
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5. Polyunsaturated Fatty Acids Attenuate Diet Induced Obesity and Insulin Resistance, Modulating Mitochondrial Respiratory Uncoupling in Rat Skeletal Muscle

Author

Giovanna Trinchese, Giorgio Gifuni, Chiara De Filippo, Gina Cavaliere, Bottu Heleena Moni, Maria Pina Mollica, Giuseppina Mattace Raso, Paolo Bergamo, Roberto Berni Canani, Rosalba Putti, Rosaria Meli, Cavaliere, Gina, Trinchese, Giovanna, Bergamo, Paolo, DE FILIPPO, Chiara, MATTACE RASO, Giuseppina, Gifuni, Giorgio, Putti, Rosalba, Moni, Bottu Heleena, BERNI CANANI, Roberto, Meli, Rosaria, and Mollica, MARIA PINA

Subjects
0301 basic medicine, Male, Bioenergetics, Physiology, Wistar, lcsh:Medicine, Mitochondrion, medicine.disease_cause, Biochemistry, Fats, Endocrinology, Medicine and Health Sciences, Respiratory system, lcsh:Science, Musculoskeletal System, Energy-Producing Organelles, chemistry.chemical_classification, Omega-3, Multidisciplinary, Muscles, Fatty Acids, Endoplasmic Reticulum Stress, Lipids, Mitochondria, medicine.anatomical_structure, Cellular Structures and Organelles, Anatomy, Research Article, Polyunsaturated fatty acid, medicine.medical_specialty, Biology, 03 medical and health sciences, Insulin resistance, Oxygen Consumption, Internal medicine, Fatty Acids, Omega-3, medicine, Animals, Animals, Dietary Fats, Endoplasmic Reticulum Stress, Fatty Acids, Omega-3, Male, Mitochondria, Obesity, Oxidative Stress, Oxygen Consumption, Rats, Wistar, Obesity, Rats, Wistar, Muscle, Skeletal, Nutrition, Endocrine Physiology, lcsh:R, Biology and Life Sciences, Skeletal muscle, Cell Biology, medicine.disease, Dietary Fats, Mitochondria, Muscle, Diet, Rats, Oxidative Stress, 030104 developmental biology, Skeletal Muscles, chemistry, lcsh:Q, Insulin Resistance, Oxidative stress
Abstract

OBJECTIVES:Omega (ω)-3 polyunsaturated fatty acids (PUFA) are dietary compounds able to attenuate insulin resistance. Anyway, the precise actions of ω-3PUFAs in skeletal muscle are overlooked. We hypothesized that PUFAs, modulating mitochondrial function and efficiency, would ameliorate pro-inflammatory and pro-oxidant signs of nutritionally induced obesity. STUDY DESIGN:To this aim, rats were fed a control diet (CD) or isocaloric high fat diets containing either ω-3 PUFA (FD) or lard (LD) for 6 weeks. RESULTS:FD rats showed lower weight, lipid gain and energy efficiency compared to LD-fed animals, showing higher energy expenditure and O2 consumption/CO2 production. Serum lipid profile and pro-inflammatory parameters in FD-fed animals were reduced compared to LD. Accordingly, FD rats exhibited a higher glucose tolerance revealed by an improved glucose and insulin tolerance tests compared to LD, accompanied by a restoration of insulin signalling in skeletal muscle. PUFAs increased lipid oxidation and reduced energy efficiency in subsarcolemmal mitochondria, and increase AMPK activation, reducing both endoplasmic reticulum and oxidative stress. Increased mitochondrial respiration was related to an increased mitochondriogenesis in FD skeletal muscle, as shown by the increase in PGC1-α and -β. CONCLUSIONS:our data strengthened the association of high dietary ω3-PUFA intake with reduced mitochondrial energy efficiency in the skeletal muscle.

Published
2016

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