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569 results on '"Mongiat-Artus P"'

1. Health-related quality of life of patients with prostate cancer initiating GnRH agonist therapy: the PRISME study

Author

François Rozet, Christophe Hennequin, Pierre Mongiat-Artus, Nathalie Pello-Leprince-Ringuet, Anne-Sophie Grandoulier, and Morgan Roupret

Subjects
Prostate cancer, quality of life, GnRH agonist, elderly, cognitive function, Medicine (General), R5-920, Physiology, QP1-981
Abstract

Objectives To compare the evolution of health-related quality of life (HRQoL) over 6 months of GnRH agonist (GnRHa) therapy among age groups for patients with prostate cancer (PCa).Patients and methods PRISME (NCT03516110) was a non-interventional, prospective study conducted in France in patients aged ≥60 years with PCa initiating GnRHa therapy within routine care. HRQoL was evaluated at baseline and after 6 months using the EORTC quality of life in ELDerly cancer patients 14 items (QLQ-ELD14) questionnaire. Cognitive status was assessed using the Mini Mental State Examination (MMSE). Analyses of covariance compared the evolution of the change from baseline of the QLQ-ELD14 scores among age groups.Results 814 patients were enrolled (245, 60–70 years; 314, 70–75 years; 252, ≥75 years). Slight or no changes were observed in each QLQ-ELD14 dimension between baseline and 6 months, overall and by age. In the primary effectiveness analysis, there was no difference among age groups in the change from baseline in QLQ-ELD14 scores. Baseline cognitive status was lower in the oldest age group, but there were no changes in all age groups. As expected, sexual function declined in all age groups.Conclusion GnRHa therapy influence on HRQoL, cognition and sexuality appeared independent of age.

Published
2024
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3. Salvage radiotherapy for patients with PSA relapse after radical prostatectomy: a single institution experience

Author

Desgrandchamps François, Maylin Claude, Ravery Vincent, Mongiat-Artus Pierre, Quero Laurent, and Hennequin Christophe

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background To assess the efficacy of salvage radiotherapy (RT) for persistent or rising PSA after radical prostatectomy and to determine prognostic factors identifying patients who may benefit from salvage RT. Methods Between 1990 and 2003, 59 patients underwent RT for PSA recurrence after radical prostatectomy. Patients received a median of 66 Gy to the prostate bed with 3D or 2D RT. The main end point was biochemical failure after salvage RT, defined as an increase of the serum PSA value >0.2 ng/ml confirmed by a second elevation. Results Median follow-up was 38 months. The 3-year and 5-year bDFS rates were 56.1% and 41.2% respectively. According to multivariate analysis, only preRT PSA ≥1 ng/ml was associated with biochemical relapse. Conclusion When delivered early, RT is an effective treatment after radical prostatectomy. Only preRT PSA ≥1 ng/ml predicted relapse.

Published
2008
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11. Fosfomycin-trometamol (FT) or fluoroquinolone (FQ) as single-dose prophylaxis for transrectal ultrasound-guided prostate biopsy (TRUS-PB): A prospective cohort study

Author

Tristan Delory, Annabelle Goujon, Alexandra Masson-Lecomte, Pauline Arias, Anthony Laurancon-Fretar, Béatrice Bercot, Pierre Mongiat-Artus, Jean-Michel Molina, and Matthieu Lafaurie

Subjects
Fosfomycin, Fluoroquinolones, Prophylaxis, Prostate Biopsy, Cohort study, Infectious and parasitic diseases, RC109-216
Abstract

Objectives: The increasing incidence of fluoroquinolones (FQ) resistance may lower its efficacy in preventing UTI following transrectal ultrasound-guided prostate biopsy (TRUS-PB). We assessed the efficacy and safety of FQ and fosfomycin-trometamol (FT) in patients undergoing TRUS-PB. Methods: A prospective observational study was conducted between April 2017 and June 2019 and enrolled men undergoing TRUS-PB and receiving a single-dose of FQ (FQ-arm) or FT (FT-arm) for UTI prophylaxis per physician’s choice. The primary efficacy endpoint was self-reported TRUS-PB UTI. We assessed baseline factors associated with UTI with logistic regression. Results: A total of 222 men were enrolled, 141/222 (64%) received FQ, and 81/222 (36%) FT. The median age was 67.6 years [IQR, 61.4–72.1] and the Charlson score was 3 [IQR, 3–5]. The overall incidence of self-reported TRUS-PB UTI was 12% (24/197, (95%CI, 8%–17%)): 15% (17/116, (95% CI, 10%–17%)) in FQ-arm, versus 9% (7/81, 95% CI (5%–13%)) in FT-arm (RR = 0.55 (95% CI, 0.22–1.40), p-value = 0.209). No baseline characteristic was significantly associated with TRUS-PB UTI. Safety was similar between the arms: the rate of the reported adverse event was 31% (36/116, (95% CI, 25%–37%) in the FQ-arm versus 36% (28/81, (95% CI, 28%–41%)) in the FT-arm (RR = 1.17 (95% CI, 0.64–2.15), p = 0.602). Conclusions: TRUS-PB UTI prophylaxis with FT and FQ has similar efficacy and safety. A randomized comparison of these two antibiotics is warranted.

Published
2021
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25. Deep Neural Networks Outperform the CAPRA Score in Predicting Biochemical Recurrence After Prostatectomy

Author

Paul Sargos, Nicolas Leduc, Nicolas Giraud, Giorgio Gandaglia, Mathieu Roumiguié, Guillaume Ploussard, Francois Rozet, Michel Soulié, Romain Mathieu, Pierre Mongiat Artus, Tamim Niazi, Vincent Vinh-Hung, and Jean-Baptiste Beauval

Subjects
prostate cancer, machine learning, predictive, recurrence, biochemical, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

BackgroundUse of predictive models for the prediction of biochemical recurrence (BCR) is gaining attention for prostate cancer (PCa). Specifically, BCR occurs in approximately 20–40% of patients five years after radical prostatectomy (RP) and the ability to predict BCR may help clinicians to make better treatment decisions. We aim to investigate the accuracy of CAPRA score compared to others models in predicting the 3-year BCR of PCa patients.Material and MethodsA total of 5043 men who underwent RP were analyzed retrospectively. The accuracy of CAPRA score, Cox regression analysis, logistic regression, K-nearest neighbor (KNN), random forest (RF) and a densely connected feed-forward neural network (DNN) classifier were compared in terms of 3-year BCR predictive value. The area under the receiver operating characteristic curve was mainly used to assess the performance of the predictive models in predicting the 3 years BCR of PCa patients. Pre-operative data such as PSA level, Gleason grade, and T stage were included in the multivariate analysis. To measure potential improvements to the model performance due to additional data, each model was trained once more with an additional set of post-operative surgical data from definitive pathology.ResultsUsing the CAPRA score variables, DNN predictive model showed the highest AUC value of 0.7 comparing to the CAPRA score, logistic regression, KNN, RF, and cox regression with 0.63, 0.63, 0.55, 0.64, and 0.64, respectively. After including the post-operative variables to the model, the AUC values based on KNN, RF, and cox regression and DNN were improved to 0.77, 0.74, 0.75, and 0.84, respectively.ConclusionsOur results showed that the DNN has the potential to predict the 3-year BCR and outperformed the CAPRA score and other predictive models.

Published
2021
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27. Effets cardio-vasculaires des traitements anticholinergiques à visée vésicale chez la personne âgée : une revue

Author

Chesnel, C., Charlanes, A., Hentzen, C., Turmel, N., Biardeau, X., Brochard, C., Campagne, S., Capon, G., Deffieux, X., Fatton, B., Gamé, X., Haddad, R., Jeandel, C., Kerdraon, J., Manceau, P., Mares, P., Mezzadri, M., Mongiat-Artus, P., Petit, A.-C., Peyronnet, B., Soler, J.-M., Thuillier, C., Vetel, J.-M., Robain, G., and Amarenco, G.

Published
2018
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29. Urinary function and quality of life after radiotherapy for prostate cancer in patients with prior history of surgical treatment for benign prostatic hyperplasia

Author

Mélanie Guilhen, Christophe Hennequin, Idir Ouzaid, Ingrid Fumagalli, Valentine Martin, Sophie Guillerm, Pierre Mongiat-Artus, Vincent Ravery, François Desgrandchamps, and Laurent Quéro

Subjects
Radiotherapy, TURP, Prostate, Cancer, IPSS, Toxicity, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background To evaluate long-term IPSS score and urinary quality of life after radiotherapy for prostate cancer, in patients with prior history of surgical treatment for benign prostatic hyperplasia (BPH). Methods In this retrospective study, we reviewed medical records of patients treated in our department, between 2007 and 2013 with surgery for BPH followed by radiotherapy for localized prostate cancer. Patients were contacted to fill in IPSS questionnaire and they were also asked for urinary quality of life. Predictive factors known to be associated with bad urinary function were also analysed. Results Fifty-nine patients were included in our study. Median age was 70 years. Median follow-up was 4.6 years. Median radiotherapy dose was 78 Gy (5 × 2 Gy/week). Thirty patients (48.5%) received hormone therapy in combination with RT. Main surgery indications were urinary symptoms (65%) and urinary retention (20%). Five-year biochemical-disease free survival was 75% and 5-year clinical relapse free survival was 84%. At the time of the study, the IPSS after radiotherapy was as follows: 0–7: 77.6%; 8–19:20.7%; 20–35: 1.7%. Urinary quality of life was satisfactory for 74.2% of patients. After multivariate analysis, a high dose of RT and a medical history of hypertension were associated with a poorer quality of urinary life (p = 0.04). Conclusion External radiotherapy remains an appropriate treatment option without a major risk for deterioration in urinary function in patient with antecedent surgery for BPH. High dose of RT and a medical history of hypertension were associated with a poorer quality of urinary life.

Published
2018
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36. Improved decision making in intermediate-risk prostate cancer: a multicenter study on pathologic and oncologic outcomes after radical prostatectomy

Author

Beauval, Jean Baptiste, Ploussard, Guillaume, Cabarrou, Bastien, Roumiguié, Mathieu, Ouzzane, Adil, Gas, Jérome, Goujon, Annabelle, Marcq, Gautier, Mathieu, Romain, Vincendeau, Sébastien, Cathelineau, Xavier, Mongiat-Artus, Pierre, Salomon, Laurent, Soulié, Michel, Méjean, Arnaud, de La Taille, Alexandre, Rouprêt, Morgan, Rozet, François, and Committee of Cancerology of the Association of French Urology

Published
2017
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