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2. Disruption of Astrocyte-Dependent Dopamine Control in the Developing Medial Prefrontal Cortex Leads to Excessive Grooming in Mice

Author

Petrelli, Francesco, Zehnder, Tamara, Laugeray, Anthony, Mondoloni, Sarah, Calì, Corrado, Pucci, Luca, Molinero Perez, Alicia, Bondiolotti, Bianca Maria, De Oliveira Figueiredo, Eva, Dallerac, Glenn, Déglon, Nicole, Giros, Bruno, Magrassi, Lorenzo, Mothet, Jean-Pierre, Mameli, Manuel, Simmler, Linda D., and Bezzi, Paola

Published
2023
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6. Serotonin release in the habenula during emotional contagion promotes resilience.

Author

Mondoloni, Sarah, Molina, Patricia, Lecca, Salvatore, Wu, Cheng-Hsi, Michel, Léo, Osypenko, Denys, Cachin, Fanchon, Flanigan, Meghan, Congiu, Mauro, Lalive, Arnaud L., Kash, Thomas, Deng, Fei, Li, Yulong, and Mameli, Manuel

Subjects
*EMOTIONAL contagion, *SEROTONIN, *PSYCHOLOGICAL resilience, *EMOTIONS
Abstract

Negative emotional contagion—witnessing others in distress—affects an individual’s emotional responsivity. However, whether it shapes coping strategies when facing future threats remains unknown. We found that mice that briefly observe a conspecific being harmed become resilient, withstanding behavioral despair after an adverse experience. Photometric recordings during negative emotional contagion revealed increased serotonin (5-HT) release in the lateral habenula. Whereas 5-HT and emotional contagion reduced habenular burst firing, limiting 5-HT synthesis prevented burst plasticity. Enhancing raphe-to-habenula 5-HT was sufficient to recapitulate resilience. In contrast, reducing 5-HT release in the habenula made witnessing a conspecific in distress ineffective to promote the resilient phenotype after adversity. These findings reveal that 5-HT supports vicarious emotions and leads to resilience by tuning definite patterns of habenular neuronal activity. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Individual variations in reward-seeking adaptability emerge among isogenic mice living in a micro-society and predict their response to nicotine

Author

Fayad, Sophie L, primary, Reynolds, Lauren Mackenzie, additional, Torquet, Nicolas, additional, Tolu, Stefania, additional, Mondoloni, Sarah, additional, Nguyen, Claire, additional, Justo, Robin, additional, Didienne, Steve, additional, Debray, Nicolas, additional, Viollet, Cecile, additional, Raynaud, Louis, additional, Layadi, Yasmine, additional, Hannesse, Bernadette, additional, Ana Marta, Capaz, additional, Topilko, Thomas, additional, Renier, Nicolas, additional, Mourot, Alexandre, additional, Marti, Fabio, additional, and Faure, Philippe, additional

Published
2023
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8. The interpeduncular nucleus blunts the rewarding effect of nicotine

Author

Jehl, Joachim, primary, Ciscato, Maria, additional, Vicq, Eleonore, additional, Dejean de la Batie, Gabrielle, additional, Guyon, Nicolas, additional, Mondoloni, Sarah, additional, Frangieh, Jacinthe, additional, Nguyen, Claire, additional, Hardelin, Jean-Pierre, additional, Marti, Fabio, additional, Corringer, Pierre-Jean, additional, Faure, Philippe, additional, and Mourot, Alexandre, additional

Published
2023
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9. Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice

Author

Dongelmans, Malou, Durand-de Cuttoli, Romain, Nguyen, Claire, Come, Maxime, Duranté, Etienne K., Lemoine, Damien, Brito, Raphaël, Ahmed Yahia, Tarek, Mondoloni, Sarah, Didienne, Steve, Bousseyrol, Elise, Hannesse, Bernadette, Reynolds, Lauren M., Torquet, Nicolas, Dalkara, Deniz, Marti, Fabio, Mourot, Alexandre, Naudé, Jérémie, and Faure, Philippe

Published
2021
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10. Prolonged nicotine exposure reduces aversion to the drug in mice by altering nicotinic transmission in the interpeduncular nucleus.

Author

Mondoloni, Sarah, Nguyen, Claire, Vicq, Eléonore, Ciscato, Maria, Jehl, Joachim, Cuttoli, Romain Durand-de, Torquet, Nicolas, Tolu, Stefania, Pons, Stéphanie, Maskos, Uwe, Marti, Fabio, Faure, Philippe, and Mourot, Alexandre

Subjects
*NICOTINIC receptors, *NICOTINE, *NICOTINIC acetylcholine receptors, *KNOCKOUT mice, *AVERSION, *MICE
Abstract

Nicotine intake is likely to result from a balance between the rewarding and aversive properties of the drug, yet the individual differences in neural activity that control aversion to nicotine and their adaptation during the addiction process remain largely unknown. Using a two-bottle choice experiment, we observed considerable heterogeneity in nicotine-drinking profiles in isogenic adult male mice, with about half of the mice persisting in nicotine consumption even at high concentrations, whereas the other half stopped consuming. We found that nicotine intake was negatively correlated with nicotine-evoked currents in the interpeduncular nucleus (IPN), and that prolonged exposure to nicotine, by weakening this response, decreased aversion to the drug, and hence boosted consumption. Lastly, using knock-out mice and local gene re-expression, we identified ß4-containing nicotinic acetylcholine receptors of IPN neurons as molecular and cellular correlates of nicotine aversion. Collectively, our results identify the IPN as a substrate for individual variabilities and adaptations in nicotine consumption. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Prolonged nicotine exposure reduces aversion to the drug in mice by altering nicotinic transmission in the interpeduncular nucleus

Author

Mondoloni, Sarah, primary, Nguyen, Claire, additional, Vicq, Eléonore, additional, Jehl, Joachim, additional, Durand-de Cuttoli, Romain, additional, Torquet, Nicolas, additional, Tolu, Stefania, additional, Pons, Stéphanie, additional, Maskos, Uwe, additional, Marti, Fabio, additional, Faure, Philippe, additional, and Mourot, Alexandre, additional

Published
2021
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14. Nicotine inhibits the VTA-to-amygdala dopamine pathway to promote anxiety

Author

Nguyen, Claire, primary, Mondoloni, Sarah, additional, Le Borgne, Tinaïg, additional, Centeno, Ines, additional, Come, Maxime, additional, Jehl, Joachim, additional, Solié, Clément, additional, Reynolds, Lauren M., additional, Durand-de Cuttoli, Romain, additional, Tolu, Stefania, additional, Valverde, Sébastien, additional, Didienne, Steve, additional, Hannesse, Bernadette, additional, Fiancette, Jean-François, additional, Pons, Stéphanie, additional, Maskos, Uwe, additional, Deroche-Gamonet, Véronique, additional, Dalkara, Deniz, additional, Hardelin, Jean-Pierre, additional, Mourot, Alexandre, additional, Marti, Fabio, additional, and Faure, Philippe, additional

Published
2021
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15. Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in a foraging task

Author

Dongelmans, Malou, primary, Durand-de Cuttoli, Romain, additional, Nguyen, Claire, additional, Come, Maxime, additional, Duranté, Etienne K., additional, Lemoine, Damien, additional, Britto, Raphael, additional, Yahia, Tarek Ahmed, additional, Mondoloni, Sarah, additional, Didienne, Steve, additional, Bousseyrol, Elise, additional, Hannesse, Bernadette, additional, Reynolds, Lauren M., additional, Torquet, Nicolas, additional, Dalkara, Deniz, additional, Marti, Fabio, additional, Mourot, Alexandre, additional, Naudé, Jérémie, additional, and Faure, Philippe, additional

Published
2021
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20. A Human Polymorphism in CHRNA5 Is Linked to Relapse to Nicotine Seeking in Transgenic Rats

Author

Forget, Benoit, primary, Scholze, Petra, additional, Langa, Francina, additional, Morel, Carole, additional, Pons, Stephanie, additional, Mondoloni, Sarah, additional, Besson, Morgane, additional, Durand-de Cuttoli, Romain, additional, Hay, Audrey, additional, Tricoire, Ludovic, additional, Lambolez, Bertrand, additional, Mourot, Alexandre, additional, Faure, Philippe, additional, and Maskos, Uwe, additional

Published
2018
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21. Optically dissecting brain nicotinic receptor function with photo-controllable designer receptors

Author

Durand-de Cuttoli, Romain, Mondoloni, Sarah, Mourot, Alexandre, HAL-UPMC, Gestionnaire, Neurophysiologie et comportements = Neurophysiology and Behavior (NPS-06), Neuroscience Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
photopharmacologie Keywords: acetylcholine, acétylcholine, photopharmacology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], addiction, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], optogenetics, optogénétique, nicotine
Abstract

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels widely expressed in the central nervous system and the periphery. They play an important modulatory role in learning, memory and attention, and have been implicated in various diseases such as Alzheimer's disease, Parkinson's disease, epilepsy, schizophrenia and addiction. These receptors are activated by the endogenous neurotransmitter acetylcholine, or by nicotine, the alkaloid found in tobacco leaves. Both molecules open the ion channel and cause the movement of cations across the membrane, which directly affects neuronal excitability and synaptic plasticity. nAChRs are very heterogeneous in their subunit composition (α2-10 et β2-4), in their brain distribution (cortex, midbrain, striatum…) and in their sub-cellular localization (pre- vs post-synaptic, axonal, dendritic…). This heterogeneity highly contributes to the very diverse roles these receptors have in health and disease. The ability to activate or block a specific nAChR subtype, at a defined time and space within the brain, would greatly help obtaining a clearer picture of these various functions. To this aim, we are developing novel optogenetic pharmacology strategies for optically controlling endogenous nAChR isoforms within the mouse brain. The idea is to tether a chemical photoswitch on the surface of a cysteine-modified nAChR, and use light for rapidly and reversibly turning that receptor mutant on and off. Here we will discuss the history of optogenetic pharmacology, and the recent advances for the optical control of brain nicotinic receptors in vivo., Les récepteurs nicotiniques de l'acétylcholine (nAChR) sont des récepteurs canaux largement distribués dans le système nerveux central (SNC) et en périphérie. Les nAChR neuronaux jouent un rôle modulateur important dans l'apprentissage, la mémoire et l'attention, et sont impliqués dans de nombreuses pathologies aussi variées que la maladie d'Alzheimer, la maladie de Parkinson, l'épilepsie, la schizophrénie ou encore l'addiction à la nicotine. L'acétylcholine, neurotransmetteur endogène, et la nicotine, alcaloïde du tabac, entraînent l'ouverture du canal et permettent le passage de cations à travers la membrane plasmique, influençant ainsi l'excitabilité neuronale et la plasticité synaptique. La grande diversité des nAChR neuronaux en termes d'assemblage moléculaire (sous-unités α2-10 et β2-4), de localisation tissulaire (cortex, mésencéphale, striatum…) mais aussi sub-cellulaire (pré- vs post-synaptique, dendritique vs axonale…) contribue aux rôles variés qu'ont ces récepteurs. Pouvoir activer ou inhiber spécifiquement un sous-type de nAChR à un endroit et un instant voulus permettrait d'avancer considérablement dans la compréhension de ses différents rôles physiologiques et pathologiques. À cette fin sont développées des techniques innovantes de pharmacologie optogénétique qui permettent de contrôler optiquement des sous-types de nAChR endogènes. L'idée est de greffer un nano-interrupteur chimique sur un nAChR modifié génétiquement afin d'utiliser la lumière pour photo-contrôler spécifiquement et précisément ce récepteur modifié. Nous discuterons ici de l'historique de la technique, mais aussi des dernières avancées technologiques dans le contrôle optique de récepteurs endogènes et dans la mise en œuvre de ces outils in vivo.

Published
2017

22. Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors

Author

Durand-de Cuttoli, Romain, primary, Mondoloni, Sarah, additional, Marti, Fabio, additional, Lemoine, Damien, additional, Nguyen, Claire, additional, Naudé, Jérémie, additional, d'Izarny-Gargas, Thibaut, additional, Pons, Stéphanie, additional, Maskos, Uwe, additional, Trauner, Dirk, additional, Kramer, Richard H, additional, Faure, Philippe, additional, and Mourot, Alexandre, additional

Published
2018
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23. Author response: Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors

Author

Durand-de Cuttoli, Romain, primary, Mondoloni, Sarah, additional, Marti, Fabio, additional, Lemoine, Damien, additional, Nguyen, Claire, additional, Naudé, Jérémie, additional, d'Izarny-Gargas, Thibaut, additional, Pons, Stéphanie, additional, Maskos, Uwe, additional, Trauner, Dirk, additional, Kramer, Richard H, additional, Faure, Philippe, additional, and Mourot, Alexandre, additional

Published
2018
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24. Somatic nicotinic acetylcholine receptors control the activity of dopamine neurons and reward-related behaviors

Author

Cuttoli, Romain Durand-de, primary, Mondoloni, Sarah, additional, Marti, Fabio, additional, Lemoine, Damien, additional, Naudé, Jérémie, additional, d’Izarny-Gargas, Thibaut, additional, Pons, Stéphanie, additional, Maskos, Uwe, additional, Trauner, Dirk, additional, Kramer, Richard H., additional, Faure, Philippe, additional, and Mourot, Alexandre, additional

Published
2018
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26. Dissection optique du rôle des récepteurs nicotiniques neuronaux à l'aide de récepteurs photo-contrôlables.

Author

de Cuttoli, Romain Durand, Mondoloni, Sarah, and Mourot, Alexandre

Abstract

Copyright of Biologie Aujourd'hui is the property of EDP Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017
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27. [Optically dissecting brain nicotinic receptor function with photo-controllable designer receptors].

Author

Durand-de Cuttoli R, Mondoloni S, and Mourot A

Subjects
Animals, Brain drug effects, Designer Drugs pharmacology, Humans, Photochemistry methods, Brain metabolism, Nicotinic Agonists pharmacology, Nicotinic Antagonists pharmacology, Optogenetics methods, Photochemical Processes drug effects, Receptors, Nicotinic physiology
Abstract

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels widely expressed in the central nervous system and the periphery. They play an important modulatory role in learning, memory and attention, and have been implicated in various diseases such as Alzheimer's disease, Parkinson's disease, epilepsy, schizophrenia and addiction. These receptors are activated by the endogenous neurotransmitter acetylcholine, or by nicotine, the alkaloid found in tobacco leaves. Both molecules open the ion channel and cause the movement of cations across the membrane, which directly affects neuronal excitability and synaptic plasticity. nAChRs are very heterogeneous in their subunit composition (α2-10 et β2-4), in their brain distribution (cortex, midbrain, striatum…) and in their sub-cellular localization (pre- vs post-synaptic, axonal, dendritic…). This heterogeneity highly contributes to the very diverse roles these receptors have in health and disease. The ability to activate or block a specific nAChR subtype, at a defined time and space within the brain, would greatly help obtaining a clearer picture of these various functions. To this aim, we are developing novel optogenetic pharmacology strategies for optically controlling endogenous nAChR isoforms within the mouse brain. The idea is to tether a chemical photoswitch on the surface of a cysteine-modified nAChR, and use light for rapidly and reversibly turning that receptor mutant on and off. Here we will discuss the history of optogenetic pharmacology, and the recent advances for the optical control of brain nicotinic receptors in vivo., (© Société de Biologie, 2017.)

Published
2017
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