1,214 results on '"Mondello, P"'
Search Results
2. Parallel coupling of gas chromatography to mass spectrometry and solid deposition Fourier transform infrared spectroscopy: an innovative approach to address challenging identifications
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Coppolino, Carmelo, Trovato, Emanuela, Salerno, Tania M. G., Cucinotta, Lorenzo, Sciarrone, Danilo, Donato, Paola, and Mondello, Luigi
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- 2024
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3. Life cycle–based assessment methods for circular economy strategies in the agri-food sector
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Mondello, Giovanni, Niero, Monia, Falcone, Giacomo, Neri, Elena, and Arcese, Gabriella
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- 2024
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4. Gromov-Hausdorff stability of tori under Ricci and integral scalar curvature bounds
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Honda, Shouhei, Ketterer, Christian, Mondello, Ilaria, Perales, Raquel, and Rigoni, Chiara
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Mathematics - Differential Geometry ,Mathematics - Metric Geometry - Abstract
We establish a nonlinear analogue of a splitting map into a Euclidean space, as a harmonic map into a flat torus. We prove that the existence of such a map implies Gromov-Hausdorff closeness to a flat torus in any dimension. Furthermore, Gromov-Hausdorff closeness to a flat torus and an integral bound {on $r_M(x)$, the smallest eigenvalue of the Ricci tensor $\text{ric}_x$ in $x$}, imply the existence of a harmonic splitting map. Combining these results with Stern's inequality, we provide a new Gromov-Hausdorff stability theorem for flat $3$-tori. The main tools we employ include the harmonic map heat flow, Ricci flow, and both Ricci limits and RCD theories., Comment: 44 pages. We corrected a mistake in Theorem 5.3, present in the previous version, and added Theorem 1.8
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- 2023
5. Silencing GNAS enhances HDAC3i efficacy in CREBBP wild type B cell lymphoma
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Mondello, Patrizia
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- 2024
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6. Assessing the environmental impacts of soilless systems: a comprehensive literature review of Life Cycle Assessment studies
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Licastro, Antonio, Salomone, Roberta, Mondello, Giovanni, and Calabrò, Grazia
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- 2024
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7. Development of dye-sensitized solar cells using pigment extracts produced by Talaromyces atroroseus GH2
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Tropea, Alessia, Spadaro, Donatella, Trocino, Stefano, Giuffrida, Daniele, Salerno, Tania Maria Grazia, Ruiz-Sanchez, Juan Pablo, Montañez, Julio, Morales-Oyervides, Lourdes, Dufossé, Laurent, Mondello, Luigi, and Calogero, Giuseppe
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- 2024
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8. Linking Symptom Inventories using Semantic Textual Similarity
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Kennedy, Eamonn, Vadlamani, Shashank, Lindsey, Hannah M, Peterson, Kelly S, OConnor, Kristen Dams, Murray, Kenton, Agarwal, Ronak, Amiri, Houshang H, Andersen, Raeda K, Babikian, Talin, Baron, David A, Bigler, Erin D, Caeyenberghs, Karen, Delano-Wood, Lisa, Disner, Seth G, Dobryakova, Ekaterina, Eapen, Blessen C, Edelstein, Rachel M, Esopenko, Carrie, Genova, Helen M, Geuze, Elbert, Goodrich-Hunsaker, Naomi J, Grafman, Jordan, Haberg, Asta K, Hodges, Cooper B, Hoskinson, Kristen R, Hovenden, Elizabeth S, Irimia, Andrei, Jahanshad, Neda, Jha, Ruchira M, Keleher, Finian, Kenney, Kimbra, Koerte, Inga K, Liebel, Spencer W, Livny, Abigail, Lovstad, Marianne, Martindale, Sarah L, Max, Jeffrey E, Mayer, Andrew R, Meier, Timothy B, Menefee, Deleene S, Mohamed, Abdalla Z, Mondello, Stefania, Monti, Martin M, Morey, Rajendra A, Newcombe, Virginia, Newsome, Mary R, Olsen, Alexander, Pastorek, Nicholas J, Pugh, Mary Jo, Razi, Adeel, Resch, Jacob E, Rowland, Jared A, Russell, Kelly, Ryan, Nicholas P, Scheibel, Randall S, Schmidt, Adam T, Spitz, Gershon, Stephens, Jaclyn A, Tal, Assaf, Talbert, Leah D, Tartaglia, Maria Carmela, Taylor, Brian A, Thomopoulos, Sophia I, Troyanskaya, Maya, Valera, Eve M, van der Horn, Harm Jan, Van Horn, John D, Verma, Ragini, Wade, Benjamin SC, Walker, Willian SC, Ware, Ashley L, Werner Jr, J Kent, Yeates, Keith Owen, Zafonte, Ross D, Zeineh, Michael M, Zielinski, Brandon, Thompson, Paul M, Hillary, Frank G, Tate, David F, Wilde, Elisabeth A, and Dennis, Emily L
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
An extensive library of symptom inventories has been developed over time to measure clinical symptoms, but this variety has led to several long standing issues. Most notably, results drawn from different settings and studies are not comparable, which limits reproducibility. Here, we present an artificial intelligence (AI) approach using semantic textual similarity (STS) to link symptoms and scores across previously incongruous symptom inventories. We tested the ability of four pre-trained STS models to screen thousands of symptom description pairs for related content - a challenging task typically requiring expert panels. Models were tasked to predict symptom severity across four different inventories for 6,607 participants drawn from 16 international data sources. The STS approach achieved 74.8% accuracy across five tasks, outperforming other models tested. This work suggests that incorporating contextual, semantic information can assist expert decision-making processes, yielding gains for both general and disease-specific clinical assessment.
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- 2023
9. Genome and Compound Analysis of Sioxanthin-Producing Marine Actinobacterium Micromonospora sp. nov. Strain SH-82 Isolated from Sponge Scopalina hapalia
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Ramesh, Chatragadda, Anwesh, Maile, Alessia, Tropea, Giuffrida, Daniele, La Tella, Roberta, Chiaia, Valentina, Mondello, Luigi, Anil, Kanakam, Le Loarer, Alexandre, Gauvin-Bialecki, Anne, Fouillaud, Mireille, and Dufossé, Laurent
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- 2024
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10. Tetraploid European paeonies (Paeonia) show a homogeneous karyotype asymmetry and structure
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Lorenzo Peruzzi, Jacopo Franzoni, Antonio Giacò, Emanuela Abidi, Emiliano Alù, Giulio Barone, Elisabetta Bianchi, Chiara Cataudella, Emanuela Di Iorio, Maria Guerrina, Fabio Mondello, Luca Paino, Mario Pentassuglia, Manuela Porrovecchio, Giovanni Rivieccio, Eugenia Siccardi, Adriano Stinca, Alessio Tei, Virginia Volanti, and Manuel Tiburtini
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Botany ,QK1-989 - Abstract
Within a practical course of cytotaxonomy organized in Pisa (Italy) on February 2024 by the Group for Floristics, Systematics and Evolution of the Italian Botanical Society, we tested whether relevant differences in karyotype asymmetry and structure occur in four tetraploid European taxa from Paeonia sect. Paeonia (P. mascula subsp. russoi, P. officinalis subsp. huthii, P. officinalis subsp. italica, and P. peregrina). Our results point towards a homogeneous karyotype asymmetry and structure among studied tetraploid species, with no statistically significant difference among taxa and high overlap in variation highlighted by PCA.
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- 2024
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11. Different observers introduce not negligible biases in comparative karyomorphological studies
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Lorenzo Peruzzi, Jacopo Franzoni, Manuel Tiburtini, Emanuela Abidi, Emiliano Alù, Giulio Barone, Elisabetta Bianchi, Chiara Cataudella, Emanuela Di Iorio, Maria Guerrina, Fabio Mondello, Luca Paino, Mario Pentassuglia, Manuela Porrovecchio, Giovanni Rivieccio, Eugenia Siccardi, Adriano Stinca, Alessio Tei, Virginia Volanti, and Antonio Giacò
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Genetics ,QH426-470 - Abstract
Within a practical course of cytotaxonomy organized in Pisa (Italy) on February 2024 by the Group for Floristics, Systematics and Evolution of the Italian Botanical Society, we tested whether using image analysis softwares possible biases are still introduced by different observers. We conclude that observer bias selectively applies in possibly overestimating the length of short arms in a karyotype. As a consequence, the parameters most sensitive to these possible errors are CVCI and CVCL, and to a less degree MCA and THL. To achieve more stable results among observers, a still lacking standardized measurement protocol could be helpful.
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- 2024
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12. Cord blood transfusions in extremely low gestational age neonates to reduce severe retinopathy of prematurity: results of a prespecified interim analysis of the randomized BORN trial
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Luciana Teofili, Patrizia Papacci, Carlo Dani, Francesco Cresi, Giulia Remaschi, Claudio Pellegrino, Maria Bianchi, Giulia Ansaldi, Maria Francesca Campagnoli, Barbara Vania, Domenico Lepore, Fabrizio Gaetano Saverio Franco, Marco Fabbri, Roberta Penta de Vera d’ Aragona, Anna Molisso, Enrico Beccastrini, Antonella Dragonetti, Lorenzo Orazi, Tina Pasciuto, Iolanda Mozzetta, Antonio Baldascino, Emanuela Locatelli, Caterina Giovanna Valentini, Carmen Giannantonio, Brigida Carducci, Sabrina Gabbriellini, Roberto Albiani, Elena Ciabatti, Nicola Nicolotti, Silvia Baroni, Alessandro Mazzoni, Federico Genzano Besso, Francesca Serrao, Velia Purcaro, Alessandra Coscia, Roberta Pizzolo, Genny Raffaeli, Stefania Villa, Isabella Mondello, Alfonso Trimarchi, Flavia Beccia, Stefano Ghirardello, and Giovanni Vento
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ELGAN ,ROP ,Transfusions ,HbF ,Umbilical blood ,Randomized controlled trial ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Preterm infants are at high risk for retinopathy of prematurity (ROP), with potential life-long visual impairment. Low fetal hemoglobin (HbF) levels predict ROP. It is unknown if preventing the HbF decrease also reduces ROP. Methods BORN is an ongoing multicenter double-blinded randomized controlled trial investigating whether transfusing HbF-enriched cord blood-red blood cells (CB-RBCs) instead of adult donor-RBC units (A-RBCs) reduces the incidence of severe ROP (NCT05100212). Neonates born between 24 and 27 + 6 weeks of gestation are enrolled and randomized 1:1 to receive adult donor-RBCs (A-RBCs, arm A) or allogeneic CB-RBCs (arm B) from birth to the postmenstrual age (PMA) of 31 + 6 weeks. Primary outcome is the rate of severe ROP at 40 weeks of PMA or discharge, with a sample size of 146 patients. A prespecified interim analysis was scheduled after the first 58 patients were enrolled, with the main purpose to evaluate the safety of CB-RBC transfusions. Results Results in the intention-to-treat and per-protocol analysis are reported. Twenty-eight patients were in arm A and 30 in arm B. Overall, 104 A-RBC units and 49 CB-RBC units were transfused, with a high rate of protocol deviations. A total of 336 adverse events were recorded, with similar incidence and severity in the two arms. By per-protocol analysis, patients receiving A-RBCs or both RBC types experienced more adverse events than non-transfused patients or those transfused exclusively with CB-RBCs, and suffered from more severe forms of bradycardia, pulmonary hypertension, and hemodynamically significant patent ductus arteriosus. Serum potassium, lactate, and pH were similar after CB-RBCs or A-RBCs. Fourteen patients died and 44 were evaluated for ROP. Ten of them developed severe ROP, with no differences between arms. At per-protocol analysis each A-RBC transfusion carried a relative risk for severe ROP of 1.66 (95% CI 1.06–2.20) in comparison with CB-RBCs. The area under the curve of HbF suggested that HbF decrement before 30 weeks PMA is critical for severe ROP development. Subsequent CB-RBC transfusions do not lessen the ROP risk. Conclusions The interim analysis shows that CB-RBC transfusion strategy in preterm neonates is safe and, if early adopted, might protect them from severe ROP. Trial registration Prospectively registered at ClinicalTrials.gov on October 29, 2021. Identifier number NCT05100212.
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- 2024
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13. Kato meets Bakry-\'Emery
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Carron, Gilles, Mondello, Ilaria, and Tewodrose, David
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Mathematics - Differential Geometry - Abstract
We prove that any complete Riemannian manifold with negative part of the Ricci curvature in a suitable Dynkin class is bi-Lipschitz equivalent to a finite-dimensional $\mathrm{RCD}$ space, by building upon the transformation rule of the Bakry-\'Emery condition under time change. We apply this result to show that our previous results on the limits of closed Riemannian manifolds satisfying a uniform Kato bound carry over to limits of complete manifolds. We also obtain a weak version of the Bishop-Gromov monotonicity formula for manifolds satisfying a strong Kato bound., Comment: 18 pages, comments are welcome!
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- 2023
14. On decorated representation spaces associated to spherical surfaces
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Mondello, Gabriele and Panov, Dmitri
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Mathematics - Differential Geometry ,Mathematics - Algebraic Geometry - Abstract
We analyse local features of the spaces of representations of the fundamental group of a punctured surface in $\mathrm{SU}_2$ equipped with a decoration, namely a choice of a logarithm of the representation at peripheral loops. Such decorated representations naturally arise as monodromies of spherical surfaces with conical points. Among other things, in this paper we determine the smooth locus of such absolute and relative decorated representation spaces: in particular, in the relative case (with few special exceptions) such smooth locus is dense, connected, and exactly consists of non-coaxial representations. The present study sheds some light on the local structure of the moduli space of spherical surfaces with conical points, which is locally modelled on the above-mentioned decorated representation spaces., Comment: 53 pages, one appendix by Daniil Mamaev
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- 2023
15. Cord blood transfusions in extremely low gestational age neonates to reduce severe retinopathy of prematurity: results of a prespecified interim analysis of the randomized BORN trial
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Teofili, Luciana, Papacci, Patrizia, Dani, Carlo, Cresi, Francesco, Remaschi, Giulia, Pellegrino, Claudio, Bianchi, Maria, Ansaldi, Giulia, Campagnoli, Maria Francesca, Vania, Barbara, Lepore, Domenico, Franco, Fabrizio Gaetano Saverio, Fabbri, Marco, de Vera d’ Aragona, Roberta Penta, Molisso, Anna, Beccastrini, Enrico, Dragonetti, Antonella, Orazi, Lorenzo, Pasciuto, Tina, Mozzetta, Iolanda, Baldascino, Antonio, Locatelli, Emanuela, Valentini, Caterina Giovanna, Giannantonio, Carmen, Carducci, Brigida, Gabbriellini, Sabrina, Albiani, Roberto, Ciabatti, Elena, Nicolotti, Nicola, Baroni, Silvia, Mazzoni, Alessandro, Besso, Federico Genzano, Serrao, Francesca, Purcaro, Velia, Coscia, Alessandra, Pizzolo, Roberta, Raffaeli, Genny, Villa, Stefania, Mondello, Isabella, Trimarchi, Alfonso, Beccia, Flavia, Ghirardello, Stefano, and Vento, Giovanni
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- 2024
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16. Comparison of “IN-REC-SUR-E” and LISA in preterm neonates with respiratory distress syndrome: a randomized controlled trial (IN-REC-LISA trial)
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Vento, Giovanni, Paladini, Angela, Aurilia, C., Ozdemir, S. Alkan, Carnielli, V. P., Cools, F., Costa, S., Cota, F., Dani, C., Davis, P. G., Fattore, S., Fè, C., Finer, N., Fusco, F. P., Gizzi, C., Herting, E., Jian, M., Lio, A., Lista, G., Mosca, F., Nobile, S., Perri, A., Picone, S., Pillow, J. J., Polglase, G., Pasciuto, T., Pastorino, R., Tana, M., Tingay, D., Tirone, C., van Kaam, A. H., Ventura, M. L., Aceti, A., Agosti, M., Alighieri, G., Ancora, G., Angileri, V., Ausanio, G., Aversa, S., Balestri, E., Baraldi, E., Barbini, M. C., Barone, C., Beghini, R., Bellan, C., Berardi, A., Bernardo, I., Betta, P., Binotti, M., Bizzarri, B., Borgarello, G., Borgione, S., Borrelli, A., Bottino, R., Bracaglia, G., Bresesti, I., Burattini, I., Cacace, C., Calzolari, F., Campagnoli, M. F., Capasso, L., Capozza, M., Capretti, M. G., Caravetta, J., Carbonara, C., Cardilli, V., Carta, M., Castoldi, F., Castronovo, A., Cavalleri, E., Cavigioli, F., Cecchi, S., Chierici, V., Cimino, C., Cocca, F., Cocca, C., Cogo, P., Coma, M., Comito, V., Condò, V., Consigli, C., Conti, R., Corradi, M., Corsello, G., Corvaglia, L. T., Costa, A., Coscia, A., Cresi, F., Crispino, F., D’Amico, P., De Cosmo, L., De Maio, C., Del Campo, G., Di Credico, S., Di Fabio, S., Di Nicola, P., Di Paolo, A., Di Valerio, S., Distilo, A., Duca, V., Falcone, A., Falsaperla, R., Fasolato, V. A., Fatuzzo, V., Favini, F., Ferrarello, M. P., Ferrari, S., Nastro, F. Fiori, Forcellini, C. A., Fracchiolla, A., Gabriele, A., Galdo, F., Gallini, F., Gangemi, A., Gargano, G., Gazzolo, D., Gentile, M. P., Ghirardello, S., Giardina, F., Giordano, L., Gitto, E., Giuffrè, M., Grappone, L., Grasso, F., Greco, I., Grison, A., Guglielmino, R., Guidotti, I., Guzzo, I., La Forgia, N., La Placa, S., La Torre, G., Lago, P., Lanciotti, L., Lavizzari, A., Leo, F., Leonardi, V., Lestingi, D., Li, J., Liberatore, P., Lodin, D., Lubrano, R., Lucente, M., Luciani, S., Luvarà, D., Maffei, G., Maggio, A., Maggio, L., Maiolo, K., Malaigia, L., Mangili, G., Manna, A., Maranella, E., Marciano, A., Marcozzi, P., Marletta, M., Marseglia, L., Martinelli, D., Martinelli, S., Massari, S., Massenzi, L., Matina, F., Mattia, L., Mescoli, G., Migliore, I. V., Minghetti, D., Mondello, I., Montano, S., Morandi, G., Mores, N., Morreale, S., Morselli, I., Motta, M., Napolitano, M., Nardo, D., Nicolardi, A., Nider, S., Nigro, G., Nuccio, M., Orfeo, L., Ottaviano, C., Paganin, P., Palamides, S., Palatta, S., Paolillo, P., Pappalardo, M. G., Pasta, E., Patti, L., Paviotti, G., Perniola, R., Perotti, G., Perrone, S., Petrillo, F., Piazza, M. S., Piccirillo, A., Pierro, M., Piga, E., Pingitore, G. A., Pisu, S., Pittini, C., Pontiggia, F., Pontrelli, G., Primavera, A., Proto, A., Quartulli, L., Raimondi, F., Ramenghi, L., Rapsomaniki, M., Ricotti, A., Rigotti, C., Rinaldi, M., Risso, F. M., Roma, E., Romanini, E., Romano, V., Rosati, E., Rosella, V., Rulli, I., Salvo, V., Sanfilippo, C., Sannia, A., Saporito, A., Sauna, A., Scapillati, E., Schettini, F., Scorrano, A., Mantelli, S. Semeria, Sepporta, V., Sindico, P., Solinas, A., Sorrentino, E., Spaggiari, E., Staffler, A., Stella, M., Termini, D., Terrin, G., Testa, A., Tina, G., Tirantello, M., Tomasini, B., Tormena, F., Travan, L., Trevisanuto, D., Tuling, G., Tulino, V., Valenzano, L., Vedovato, S., Vendramin, S., Villani, P. E., Viola, S., Viola, V., Vitaliti, G., Vitaliti, M., Wanker, P., Yang, Y., Zanetta, S., and Zannin, E.
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- 2024
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17. Multiomic analysis identifies a high-risk signature that predicts early clinical failure in DLBCL
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Wenzl, Kerstin, Stokes, Matthew E., Novak, Joseph P., Bock, Allison M., Khan, Sana, Hopper, Melissa A., Krull, Jordan E., Dropik, Abigail R., Walker, Janek S., Sarangi, Vivekananda, Mwangi, Raphael, Ortiz, Maria, Stong, Nicholas, Huang, C. Chris, Maurer, Matthew J., Rimsza, Lisa, Link, Brian K., Slager, Susan L., Asmann, Yan, Mondello, Patrizia, Morin, Ryan, Ansell, Stephen M., Habermann, Thomas M., Witzig, Thomas E., Feldman, Andrew L., King, Rebecca L., Nowakowski, Grzegorz, Cerhan, James R., Gandhi, Anita K., and Novak, Anne J.
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- 2024
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18. The state of health in the European Union (EU-27) in 2019: a systematic analysis for the Global Burden of Disease study 2019
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Santos, João Vasco, Padron-Monedero, Alicia, Bikbov, Boris, Grad, Diana Alecsandra, Plass, Dietrich, Mechili, Enkeleint A., Gazzelloni, Federica, Fischer, Florian, Sulo, Gerhard, Ngwa, Che Henry, Noguer-Zambrano, Isabel, Peñalvo, José L., Haagsma, Juanita A., Kissimova-Skarbek, Katarzyna, Monasta, Lorenzo, Ghith, Nermin, Sarmiento-Suarez, Rodrigo, Hrzic, Rok, Haneef, Romana, O’Caoimh, Rónán, Cuschieri, Sarah, Mondello, Stefania, Kabir, Zubair, Freitas, Alberto, and Devleesschauwer, Brecht
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- 2024
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19. MicroRNAs as biomarkers of brain injury in neonatal encephalopathy: an observational cohort study
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Dakroub, Fatima, Kobeissy, Firas, Mondello, Stefania, Yang, Zhihui, Xu, Haiyan, Sura, Livia, Rossignol, Candace, Albayram, Mehmet, Rajderkar, Dhanashree, Wang, Kevin, and Weiss, Michael D.
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- 2024
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20. The Use of Biofluid Markers to Evaluate the Consequences of Sport-Related Subconcussive Head Impact Exposure: A Scoping Review
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Lember, Liivia-Mari, Ntikas, Michail, Mondello, Stefania, Wilson, Lindsay, Di Virgilio, Thomas G., Hunter, Angus M., Kobeissy, Firas, Mechref, Yehia, Donaldson, David I., and Ietswaart, Magdalena
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- 2024
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21. Current hospital policies on breastfeeding: a survey from Italy
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Davanzo, Riccardo, Travan, Laura, Giannì, Maria Lorella, Giordano, Giuseppe, Perugi, Silvia, Baldassarre, Mariella, Soldi, Antonella, Colombo, Lorenzo, Mondello, Isabella, Pandullo, Michela, Ferrara, Alessia, Scarpato, Elena, and Salvatori, Guglielmo
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- 2024
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22. Determination of mineral oil hydrocarbon contamination in Citrus essential oils by using on-line liquid-gas chromatography: critical aspects
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Arena, Alessia, Zoccali, Mariosimone, Bonaccorsi, Ivana, Mondello, Monica, Tranchida, Peter Q., and Mondello, Luigi
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- 2024
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23. Circular Economy in the Food Chain: Retrieval and Characterization of Antimicrobial Peptides from Fish Waste Hydrolysates
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Salerno, Tania Maria Grazia, Coppolino, Carmelo, Arena, Paola, Aichouni, Ahmed, Cerrato, Andrea, Capriotti, Anna Laura, Rigano, Francesca, Donnarumma, Danilo, Donato, Paola, Mondello, Alice, and Mondello, Luigi
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- 2024
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24. Serum N‑Glycan Profiling of Patients with Narcolepsy Type 1 Using LC-MS/MS
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Akeem Sanni, Md Abdul Hakim, Mona Goli, Moyinoluwa Adeniyi, Farid Talih, Bartolo Lanuzza, Firas Kobeissy, Giuseppe Plazzi, Monica Moresco, Stefania Mondello, Raffaele Ferri, and Yehia Mechref
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Chemistry ,QD1-999 - Published
- 2024
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25. Comparison of 'IN-REC-SUR-E' and LISA in preterm neonates with respiratory distress syndrome: a randomized controlled trial (IN-REC-LISA trial)
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Giovanni Vento, Angela Paladini, C. Aurilia, S. Alkan Ozdemir, V. P. Carnielli, F. Cools, S. Costa, F. Cota, C. Dani, P. G. Davis, S. Fattore, C. Fè, N. Finer, F. P. Fusco, C. Gizzi, E. Herting, M. Jian, A. Lio, G. Lista, F. Mosca, S. Nobile, A. Perri, S. Picone, J. J. Pillow, G. Polglase, T. Pasciuto, R. Pastorino, M. Tana, D. Tingay, C. Tirone, A. H. van Kaam, M. L. Ventura, A. Aceti, M. Agosti, G. Alighieri, G. Ancora, V. Angileri, G. Ausanio, S. Aversa, E. Balestri, E. Baraldi, M. C. Barbini, C. Barone, R. Beghini, C. Bellan, A. Berardi, I. Bernardo, P. Betta, M. Binotti, B. Bizzarri, G. Borgarello, S. Borgione, A. Borrelli, R. Bottino, G. Bracaglia, I. Bresesti, I. Burattini, C. Cacace, F. Calzolari, M. F. Campagnoli, L. Capasso, M. Capozza, M. G. Capretti, J. Caravetta, C. Carbonara, V. Cardilli, M. Carta, F. Castoldi, A. Castronovo, E. Cavalleri, F. Cavigioli, S. Cecchi, V. Chierici, C. Cimino, F. Cocca, C. Cocca, P. Cogo, M. Coma, V. Comito, V. Condò, C. Consigli, R. Conti, M. Corradi, G. Corsello, L. T. Corvaglia, A. Costa, A. Coscia, F. Cresi, F. Crispino, P. D’Amico, L. De Cosmo, C. De Maio, G. Del Campo, S. Di Credico, S. Di Fabio, P. Di Nicola, A. Di Paolo, S. Di Valerio, A. Distilo, V. Duca, A. Falcone, R. Falsaperla, V. A. Fasolato, V. Fatuzzo, F. Favini, M. P. Ferrarello, S. Ferrari, F. Fiori Nastro, C. A. Forcellini, A. Fracchiolla, A. Gabriele, F. Galdo, F. Gallini, A. Gangemi, G. Gargano, D. Gazzolo, M. P. Gentile, S. Ghirardello, F. Giardina, L. Giordano, E. Gitto, M. Giuffrè, L. Grappone, F. Grasso, I. Greco, A. Grison, R. Guglielmino, I. Guidotti, I. Guzzo, N. La Forgia, S. La Placa, G. La Torre, P. Lago, L. Lanciotti, A. Lavizzari, F. Leo, V. Leonardi, D. Lestingi, J. Li, P. Liberatore, D. Lodin, R. Lubrano, M. Lucente, S. Luciani, D. Luvarà, G. Maffei, A. Maggio, L. Maggio, K. Maiolo, L. Malaigia, G. Mangili, A. Manna, E. Maranella, A. Marciano, P. Marcozzi, M. Marletta, L. Marseglia, D. Martinelli, S. Martinelli, S. Massari, L. Massenzi, F. Matina, L. Mattia, G. Mescoli, I. V. Migliore, D. Minghetti, I. Mondello, S. Montano, G. Morandi, N. Mores, S. Morreale, I. Morselli, M. Motta, M. Napolitano, D. Nardo, A. Nicolardi, S. Nider, G. Nigro, M. Nuccio, L. Orfeo, C. Ottaviano, P. Paganin, S. Palamides, S. Palatta, P. Paolillo, M. G. Pappalardo, E. Pasta, L. Patti, G. Paviotti, R. Perniola, G. Perotti, S. Perrone, F. Petrillo, M. S. Piazza, A. Piccirillo, M. Pierro, E. Piga, G. A. Pingitore, S. Pisu, C. Pittini, F. Pontiggia, G. Pontrelli, A. Primavera, A. Proto, L. Quartulli, F. Raimondi, L. Ramenghi, M. Rapsomaniki, A. Ricotti, C. Rigotti, M. Rinaldi, F. M. Risso, E. Roma, E. Romanini, V. Romano, E. Rosati, V. Rosella, I. Rulli, V. Salvo, C. Sanfilippo, A. Sannia, A. Saporito, A. Sauna, E. Scapillati, F. Schettini, A. Scorrano, S. Semeria Mantelli, V. Sepporta, P. Sindico, A. Solinas, E. Sorrentino, E. Spaggiari, A. Staffler, M. Stella, D. Termini, G. Terrin, A. Testa, G. Tina, M. Tirantello, B. Tomasini, F. Tormena, L. Travan, D. Trevisanuto, G. Tuling, V. Tulino, L. Valenzano, S. Vedovato, S. Vendramin, P. E. Villani, S. Viola, V. Viola, G. Vitaliti, M. Vitaliti, P. Wanker, Y. Yang, S. Zanetta, and E. Zannin
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Preterm infants ,Lung recruitment ,HFOV ,INRECSURE ,LISA ,Surfactant ,Medicine (General) ,R5-920 - Abstract
Abstract Background Surfactant is a well-established therapy for preterm neonates affected by respiratory distress syndrome (RDS). The goals of different methods of surfactant administration are to reduce the duration of mechanical ventilation and the severity of bronchopulmonary dysplasia (BPD); however, the optimal administration method remains unknown. This study compares the effectiveness of the INtubate-RECruit-SURfactant-Extubate (IN-REC-SUR-E) technique with the less-invasive surfactant administration (LISA) technique, in increasing BPD-free survival of preterm infants. This is an international unblinded multicenter randomized controlled study in which preterm infants will be randomized into two groups to receive IN-REC-SUR-E or LISA surfactant administration. Methods In this study, 382 infants born at 24+0–27+6 weeks’ gestation, not intubated in the delivery room and failing nasal continuous positive airway pressure (nCPAP) or nasal intermittent positive pressure ventilation (NIPPV) during the first 24 h of life, will be randomized 1:1 to receive IN-REC-SUR-E or LISA surfactant administration. The primary outcome is a composite outcome of death or BPD at 36 weeks’ postmenstrual age. The secondary outcomes are BPD at 36 weeks’ postmenstrual age; death; pulse oximetry/fraction of inspired oxygen; severe intraventricular hemorrhage; pneumothorax; duration of respiratory support and oxygen therapy; pulmonary hemorrhage; patent ductus arteriosus undergoing treatment; percentage of infants receiving more doses of surfactant; periventricular leukomalacia, severe retinopathy of prematurity, necrotizing enterocolitis, sepsis; total in-hospital stay; systemic postnatal steroids; neurodevelopmental outcomes; and respiratory function testing at 24 months of age. Randomization will be centrally provided using both stratification and permuted blocks with random block sizes and block order. Stratification factors will include center and gestational age (24+0 to 25+6 weeks or 26+0 to 27+6 weeks). Analyses will be conducted in both intention-to-treat and per-protocol populations, utilizing a log-binomial regression model that corrects for stratification factors to estimate the adjusted relative risk (RR). Discussion This trial is designed to provide robust data on the best method of surfactant administration in spontaneously breathing preterm infants born at 24+0–27+6 weeks’ gestation affected by RDS and failing nCPAP or NIPPV during the first 24 h of life, comparing IN-REC-SUR-E to LISA technique, in increasing BPD-free survival at 36 weeks’ postmenstrual age of life. Trial registration ClinicalTrials.gov NCT05711966. Registered on February 3, 2023.
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- 2024
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26. Peach Palm Fruit (Bactris gasipaes) Peel: A Source of Provitamin A Carotenoids to Develop Emulsion-Based Delivery Systems
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Jader Martínez-Girón, Cinzia Cafarella, Francesca Rigano, Daniele Giuffrida, Luigi Mondello, Yolima Baena, Coralia Osorio, and Luis Eduardo Ordóñez-Santos
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Chemistry ,QD1-999 - Published
- 2024
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27. Multiomic analysis identifies a high-risk signature that predicts early clinical failure in DLBCL
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Kerstin Wenzl, Matthew E. Stokes, Joseph P. Novak, Allison M. Bock, Sana Khan, Melissa A. Hopper, Jordan E. Krull, Abigail R. Dropik, Janek S. Walker, Vivekananda Sarangi, Raphael Mwangi, Maria Ortiz, Nicholas Stong, C. Chris Huang, Matthew J. Maurer, Lisa Rimsza, Brian K. Link, Susan L. Slager, Yan Asmann, Patrizia Mondello, Ryan Morin, Stephen M. Ansell, Thomas M. Habermann, Thomas E. Witzig, Andrew L. Feldman, Rebecca L. King, Grzegorz Nowakowski, James R. Cerhan, Anita K. Gandhi, and Anne J. Novak
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Recent genetic and molecular classification of DLBCL has advanced our knowledge of disease biology, yet were not designed to predict early events and guide anticipatory selection of novel therapies. To address this unmet need, we used an integrative multiomic approach to identify a signature at diagnosis that will identify DLBCL at high risk of early clinical failure. Tumor biopsies from 444 newly diagnosed DLBCL were analyzed by WES and RNAseq. A combination of weighted gene correlation network analysis and differential gene expression analysis was used to identify a signature associated with high risk of early clinical failure independent of IPI and COO. Further analysis revealed the signature was associated with metabolic reprogramming and identified cases with a depleted immune microenvironment. Finally, WES data was integrated into the signature and we found that inclusion of ARID1A mutations resulted in identification of 45% of cases with an early clinical failure which was validated in external DLBCL cohorts. This novel and integrative approach is the first to identify a signature at diagnosis, in a real-world cohort of DLBCL, that identifies patients at high risk for early clinical failure and may have significant implications for design of therapeutic options.
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- 2024
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28. The state of health in the European Union (EU-27) in 2019: a systematic analysis for the Global Burden of Disease study 2019
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João Vasco Santos, Alicia Padron-Monedero, Boris Bikbov, Diana Alecsandra Grad, Dietrich Plass, Enkeleint A. Mechili, Federica Gazzelloni, Florian Fischer, Gerhard Sulo, Che Henry Ngwa, Isabel Noguer-Zambrano, José L. Peñalvo, Juanita A. Haagsma, Katarzyna Kissimova-Skarbek, Lorenzo Monasta, Nermin Ghith, Rodrigo Sarmiento-Suarez, Rok Hrzic, Romana Haneef, Rónán O’Caoimh, Sarah Cuschieri, Stefania Mondello, Zubair Kabir, GBD 2019 EU State of Health Collaborators, Alberto Freitas, and Brecht Devleesschauwer
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European Union ,Health status ,Population health ,Global Burden of Diseases ,European Burden of Disease Network ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The European Union (EU) faces many health-related challenges. Burden of diseases information and the resulting trends over time are essential for health planning. This paper reports estimates of disease burden in the EU and individual 27 EU countries in 2019, and compares them with those in 2010. Methods We used the Global Burden of Disease 2019 study estimates and 95% uncertainty intervals for the whole EU and each country to evaluate age-standardised death, years of life lost (YLLs), years lived with disability (YLDs) and disability-adjusted life years (DALYs) rates for Level 2 causes, as well as life expectancy and healthy life expectancy (HALE). Results In 2019, the age-standardised death and DALY rates in the EU were 465.8 deaths and 20,251.0 DALYs per 100,000 inhabitants, respectively. Between 2010 and 2019, there were significant decreases in age-standardised death and YLL rates across EU countries. However, YLD rates remained mainly unchanged. The largest decreases in age-standardised DALY rates were observed for “HIV/AIDS and sexually transmitted diseases” and “transport injuries” (each -19%). “Diabetes and kidney diseases” showed a significant increase for age-standardised DALY rates across the EU (3.5%). In addition, “mental disorders” showed an increasing age-standardised YLL rate (14.5%). Conclusions There was a clear trend towards improvement in the overall health status of the EU but with differences between countries. EU health policymakers need to address the burden of diseases, paying specific attention to causes such as mental disorders. There are many opportunities for mutual learning among otherwise similar countries with different patterns of disease.
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- 2024
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29. Association of early blood-based biomarkers and six-month functional outcomes in conventional severity categories of traumatic brain injury: capturing the continuous spectrum of injuryResearch in context
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Lindsay Wilson, Virginia F.J. Newcombe, Daniel P. Whitehouse, Stefania Mondello, Andrew I.R. Maas, David K. Menon, Cecilia Ackerlund, Krisztina Amrein, Nada Andelic, Lasse Andreassen, Audny Anke, Anna Antoni, Gérard Audibert, Philippe Azouvi, Maria Luisa Azzolini, Ronald Bartels, Pál Barzó, Romuald Beauvais, Ronny Beer, Bo-Michael Bellander, Antonio Belli, Habib Benali, Maurizio Berardino, Luigi Beretta, Morten Blaabjerg, Peter Bragge, Alexandra Brazinova, Vibeke Brinck, Joanne Brooker, Camilla Brorsson, Andras Buki, Monika Bullinger, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Guillermo Carbayo Lozano, Marco Carbonara, Ana M. Castaño-León, Simona Cavallo, Giorgio Chevallard, Arturo Chieregato, Giuseppe Citerio, Hans Clusmann, Mark Steven Coburn, Jonathan Coles, Jamie D. Cooper, Marta Correia, Amra Čović, Nicola Curry, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, Paul Dark, Helen Dawes, Véronique De Keyser, Vincent Degos, Francesco Della Corte, Hugo den Boogert, Bart Depreitere, Đula Đilvesi, Abhishek Dixit, Emma Donoghue, Jens Dreier, Guy-Loup Dulière, Ari Ercole, Patrick Esser, Erzsébet Ezer, Martin Fabricius, Valery L. Feigin, Kelly Foks, Shirin Frisvold, Alex Furmanov, Pablo Gagliardo, Damien Galanaud, Dashiell Gantner, Guoyi Gao, Pradeep George, Alexandre Ghuysen, Lelde Giga, Ben Glocker, Jagoš Golubović, Pedro A. Gomez, Johannes Gratz, Benjamin Gravesteijn, Francesca Grossi, Russell L. Gruen, Deepak Gupta, Juanita A. Haagsma, Iain Haitsma, Raimund Helbok, Eirik Helseth, Lindsay Horton, Jilske Huijben, Peter J. Hutchinson, Bram Jacobs, Stefan Jankowski, Mike Jarrett, Ji-yao Jiang, Faye Johnson, Kelly Jones, Mladen Karan, Angelos G. Kolias, Erwin Kompanje, Daniel Kondziella, Evgenios Kornaropoulos, Lars-Owe Koskinen, Noémi Kovács, Ana Kowark, Alfonso Lagares, Linda Lanyon, Steven Laureys, Fiona Lecky, Didier Ledoux, Rolf Lefering, Valerie Legrand, Aurelie Lejeune, Leon Levi, Roger Lightfoot, Hester Lingsma, Marc Maegele, Marek Majdan, Alex Manara, Geoffrey Manley, Hugues Maréchal, Costanza Martino, Julia Mattern, Catherine McMahon, Béla Melegh, Tomas Menovsky, Ana Mikolic, Benoit Misset, Visakh Muraleedharan, Lynnette Murray, Nandesh Nair, Ancuta Negru, David Nelson, Daan Nieboer, József Nyirádi, Matej Oresic, Fabrizio Ortolano, Olubukola Otesile, Aarno Palotie, Paul M. Parizel, Jean-François Payen, Natascha Perera, Vincent Perlbarg, Paolo Persona, Wilco Peul, Anna Piippo-Karjalainen, Matti Pirinen, Dana Pisica, Horia Ples, Suzanne Polinder, Inigo Pomposo, Jussi P. Posti, Louis Puybasset, Andreea Rădoi, Arminas Ragauskas, Rahul Raj, Malinka Rambadagalla, Isabel Retel Helmrich, Jonathan Rhodes, Sylvia Richardson, Sophie Richter, Samuli Ripatti, Saulius Rocka, Cecilie Roe, Olav Roise, Jonathan Rosand, Jeffrey Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Daniel Rueckert, Martin Rusnák, Juan Sahuquillo, Oliver Sakowitz, Renan Sanchez-Porras, Janos Sandor, Nadine Schäfer, Silke Schmidt, Herbert Schoechl, Guus Schoonman, Rico Frederik Schou, Elisabeth Schwendenwein, Ranjit D. Singh, Charlie Sewalt, Toril Skandsen, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Simon Stanworth, Robert Stevens, William Stewart, Ewout W. Steyerberg, Nino Stocchetti, Nina Sundström, Riikka Takala, Viktória Tamás, Tomas Tamosuitis, Mark Steven Taylor, Braden Te Ao, Olli Tenovuo, Alice Theadom, Matt Thomas, Aurore Thibaut, Dick Tibboel, Marjolijn Timmers, Christos Tolias, Tony Trapani, Cristina Maria Tudora, Andreas Unterberg, Peter Vajkoczy, Egils Valeinis, Shirley Vallance, Zoltán Vámos, Mathieu van der Jagt, Joukje van der Naalt, Gregory Van der Steen, Jeroen T.J.M. van Dijck, Inge A. van Erp, Thomas A. van Essen, Wim Van Hecke, Caroline van Heugten, Dominique Van Praag, Ernest van Veen, Roel P.J. van Wijk, Thijs Vande Vyvere, Alessia Vargiolu, Emmanuel Vega, Kimberley Velt, Jan Verheyden, Paul M. Vespa, Anne Vik, Rimantas Vilcinis, Victor Volovici, Nicole von Steinbüchel, Daphne Voormolen, Peter Vulekovic, Kevin K.W. Wang, Eveline Wiegers, Guy Williams, Stefan Winzeck, Stefan Wolf, Zhihui Yang, Peter Ylén, Alexander Younsi, Frederick A. Zeiler, Veronika Zelinkova, Agate Ziverte, and Tommaso Zoerle
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Traumatic brain injury ,Blood biomarkers ,GFAP ,NFL ,UCH-L1 ,Outcomes ,Medicine ,Medicine (General) ,R5-920 - Abstract
Summary: Background: Traumatic brain injury is conventionally categorised as mild, moderate, or severe on the Glasgow Coma Scale (GCS). Recently developed biomarkers can provide more objective and nuanced measures of the extent of brain injury. Methods: Exposure–response relationships were investigated in 2479 patients aged ≥16 enrolled in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) prospective observational cohort study. Neurofilament protein-light (NFL), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and glial fibrillary acidic protein (GFAP) were assayed from serum sampled in the first 24 h; concentrations were divided into quintiles within GCS severity groups. Relationships with the Glasgow Outcome Scale-Extended were examined using modified Poisson regression including age, sex, major extracranial injury, time to sample, and log biomarker concentration as covariates. Findings: Within severity groups there were associations between biomarkers and outcomes after adjustment for covariates: GCS 13–15 and negative CT imaging (relative risks [RRs] from 1.28 to 3.72), GCS 13–15 and positive CT (1.21–2.81), GCS 9–12 (1.16–2.02), GCS 3–8 (1.09–1.94). RRs were associated with clinically important differences in expectations of prognosis. In patients with GCS 3 (RRs 1.51–1.80) percentages of unfavourable outcome were 37–51% in the lowest quintiles of biomarker levels and reached 90–94% in the highest quintiles. Similarly, for GCS 15 (RRs 1.83–3.79), the percentages were 2–4% and 19–28% in the lowest and highest biomarker quintiles, respectively. Interpretation: Conventional TBI severity classification is inadequate and underestimates heterogeneity of brain injury and associated outcomes. The adoption of circulating biomarkers can add to clinical assessment of injury severity. Funding: European Union 7th Framework program (EC grant 602150), Hannelore Kohl Stiftung, One Mind, Integra LifeSciences, Neuro-Trauma Sciences, NIHR Rosetrees Trust.
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- 2024
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30. Miniaturized extraction, fast and sustainable chromatographic approach for determination of oxygen heterocyclic compounds in alcoholic beverages
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Giovanna Cafeo, Tania Maria Grazia Salerno, Luigi Mondello, Paola Dugo, and Marina Russo
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Oxygen heterocyclic compounds ,Miniaturized extraction ,Sustainable extraction ,HPLC-QqQ/MS ,Green analytical methods ,Alcoholic beverages ,Analytical chemistry ,QD71-142 - Abstract
In this research a miniaturized liquid-liquid extraction was developed for the determination of oxygen heterocyclic compounds in alcoholic beverages. Eight coumarins, twenty-one furocoumarins and seven polymethoxyflavones were identified and quantified, even at trace level, employing a fast and eco-friendly liquid chromatography, tandem mass spectrometry method, recently developed by our research group. Chromatographic separation was obtained in four minutes, using water and ethanol as mobile phases. LOQ values for all the analytes were in the ppb range. The miniaturized vortex-extraction developed was attained in about 12 minutes, employing only 1 mL of sample and of extractant. Furthermore, it allowed to extract more samples simultaneously. Extraction recovery was satisfactory with values ranging between 87 % and 96%. Moreover, the greenness of the proposed methodology was calculated employing the sample preparation method of sustainability metric, which allowed to weigh only the effect of the extraction techniques. Results, expressed in scores from 1-10, gave a value of 6.00, for the newly developed method against the 3.89 rated for a classic liquid-liquid extraction. All the sample analysed contained oxygen heterocyclic compounds in various concentrations with a minimum content of 38.8 µg L−1 and a maximum concentration of 49361 µg L−1.
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- 2024
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31. MicroRNAs as biomarkers of brain injury in neonatal encephalopathy: an observational cohort study
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Fatima Dakroub, Firas Kobeissy, Stefania Mondello, Zhihui Yang, Haiyan Xu, Livia Sura, Candace Rossignol, Mehmet Albayram, Dhanashree Rajderkar, Kevin Wang, and Michael D. Weiss
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Neonatal encephalopathy ,HIE ,MicroRNA biomarkers ,Medicine ,Science - Abstract
Abstract Neonatal Encephalopathy (NE) is a major cause of lifelong disability and neurological complications in affected infants. Identifying novel diagnostic biomarkers in this population may assist in predicting MRI injury and differentiate neonates with NE from those with low-cord pH or healthy neonates and may help clinicians make real-time decisions. To compare the microRNA (miRNA) profiles between neonates with NE, healthy controls, and neonates with low cord pH. Moreover, miRNA concentrations were compared to brain injury severity in neonates with NE. This is a retrospective analysis of miRNA profiles from select samples in the biorepository and data registry at the University of Florida Health Gainesville. The Firefly miRNA assay was used to screen a total of 65 neurological miRNA targets in neonates with NE (n = 36), low cord pH (n = 18) and healthy controls (n = 37). Multivariate statistical techniques, including principal component analysis and orthogonal partial least squares discriminant analysis, and miRNA Enrichment Analysis and Annotation were used to identify miRNA markers and their pathobiological relevance. A set of 10 highly influential miRNAs were identified, which were significantly upregulated in the NE group compared to healthy controls. Of these, miR-323a-3p and mir-30e-5p displayed the highest fold change in expression levels. Moreover, miR-34c-5p, miR-491-5p, and miR-346 were significantly higher in the NE group compared to the low cord pH group. Furthermore, several miRNAs were identified that can differentiate between no/mild and moderate/severe injury in the NE group as measured by MRI. MiRNAs represent promising diagnostic and prognostic tools for improving the management of NE.
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- 2024
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32. Phytochemical Investigations, Antioxidant and Insecticidal Properties of Essential Oil and Extracts from the Aerial Parts of Pelargonium graveolens from Morocco
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Zakya M’hamdi, Federica Davì, Mohammed Elhourri, Ali Amechrouq, Fabio Mondello, Francesco Cacciola, Roberto Laganà Vinci, Luigi Mondello, Natalizia Miceli, and Maria Fernanda Taviano
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Pelargonium graveolens L’Hér. ,HPLC-PDA/ESI-MS ,antioxidant activity ,botanical insecticide ,Sitophilus oryzae L. ,phenolic compounds ,Organic chemistry ,QD241-441 - Abstract
The essential oil and the aqueous and ethanolic extracts obtained from the aerial parts of Pelargonium graveolens cultivated in Morocco were studied for their antioxidant and insecticidal activity against rice weevils (Sitophylus oryzae). The total phenolic content of the extracts was determined by a spectrophotometric method and the phenolic compounds were extensively characterized by HPLC-PDA/ESI-MS. To evaluate antioxidant potential, three in vitro assays were used. In the DPPH test, the ethanolic extract was the most active, followed by the aqueous extract and the essential oil. In the reducing power assay, excellent activity was highlighted for both extracts, while in the Fe2+ chelating activity assay, weak activity was observed for both the essential oil and the ethanolic extract and no activity for the aqueous extract. Concerning insecticide activity, the toxicity of the essential oil and the extracts was tested against rice weevils; the lethal concentrations LC50 and LC99 were determined, as well as the lethal time required for the death of 50% (LT50) and 99% (LT99) of the weevils. The essential oil had the highest activity; 100% mortality of S. oryzae was observed around 5, 9, and 8 days for the essential oil and the aqueous and ethanolic extracts, respectively.
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- 2024
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33. Torus stability under Kato bounds on the Ricci curvature
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Carron, Gilles, Mondello, Ilaria, and Tewodrose, David
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Mathematics - Differential Geometry - Abstract
We show two stability results for a closed Riemannian manifold whose Ricci curvature is small in the Kato sense and whose first Betti number is equal to the dimension. The first one is a geometric stability result stating that such a manifold is Gromov-Hausdorff close to a flat torus. The second one states that, under a stronger assumption, such a manifold is diffeomorphic to a torus: this extends a result by Colding and Cheeger-Colding obtained in the context of a lower bound on the Ricci curvature., Comment: 24 pages. Comments are welcome!
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- 2022
34. Differentiating Siegel modular forms, and the moving slope of ${\mathcal A}_g$
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Grushevsky, Samuel, Ibukiyama, Tomoyoshi, Mondello, Gabriele, and Manni, Riccardo Salvati
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Mathematics - Algebraic Geometry - Abstract
We study the cone of moving divisors on the moduli space ${\mathcal A}_g$ of principally polarized abelian varieties. Partly motivated by the generalized Rankin-Cohen bracket, we construct a non-linear holomorphic differential operator that sends Siegel modular forms to Siegel modular forms, and we apply it to produce new modular forms. Our construction recovers the known divisors of minimal moving slope on ${\mathcal A}_g$ for $g\leq 4$, and gives an explicit upper bound for the moving slope of ${\mathcal A}_5$ and a conjectural upper bound for the moving slope of ${\mathcal A}_6$.
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- 2022
35. Limits of manifolds with a Kato bound on the Ricci curvature. II
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Carron, Gilles, Mondello, Ilaria, and Tewodrose, David
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Mathematics - Differential Geometry - Abstract
We prove that metric measure spaces obtained as limits of closed Riemannian manifolds with Ricci curvature satisfying a uniform Kato bound are rectifiable. In the case of a non-collapsing assumption and a strong Kato bound, we additionally show that for any $\alpha \in (0,1)$ the regular part of the space lies in an open set with the structure of a $\mathcal{C}^\alpha$-manifold.
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- 2022
36. Phytochemical profile, antioxidant screening, and antidiabetic effect of pink pepper (Schinus terebinthifolius Raddi) leaves in diabetic mice
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Zakia Zouaoui, Abdelmounaim Laabar, Sara El Asri, Abdelhamid Ennoury, Imad Kabach, Luigi Mondello, Francesco Cacciola, Khalid Taghzouti, Mohamed Nhiri, and Naima Nhiri
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Diabetic mice ,Polyphenols ,Antioxidant enzymes ,Schinus terebinthifolius raddi ,Glycation ,Agriculture (General) ,S1-972 ,Nutrition. Foods and food supply ,TX341-641 - Abstract
This current research explores the health benefits of pink pepper (Schinus terebinthifolius Raddi) leaves linked to damage associated with diabetes in diabetic mice. An interesting increase in blood glycemia, total cholesterol, low-density lipoprotein, hepatic malondialdehyde (MDA), peroxide (H2O2), and renal advanced glycated end products (AGE) in comparison with the non-diabetic mice was observed. Additionally, a decrease in the high-density lipoprotein cholesterol level and antioxidant enzymes namely catalase, glutathione reductase, glutathione peroxidase, as well as superoxide dismutase in mice with hyperglycemia was appreciated, as well. The treatment with Schinus terebinthifolius Raddi methanolic extract (STME) from leaves (150 and 250 mg kg−1) for 21 days reduced markedly blood glucose, TC, LDL, hepatic malondialdehyde (MDA), H2O2 and AGE levels in kidneys of mice with abnormally glucose level; it elevated serum HDL degree and boosted the activity of hepatic redox-regulating enzymes in diabetic mice. These findings exhibit the capacity of the STME to mitigate diabetes-related hyperglycemia. The data proposed that the administration of Schinus terebinthifolius Raddi leaves extract can be useful in preventing alterations and dysfunction caused by glycation, oxidative stress, and hyperlipidemia in the pathology of diabetes. The overall results imply that phytochemical compounds of Schinus terebinthifolius Raddi leaves may represent a promising therapeutic opportunity in the search for new anti-diabetic treatments.
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- 2024
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37. Traumatic brain injury: progress and challenges in prevention, clinical care, and research.
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Maas, Andrew, Menon, David, Manley, Geoffrey, Abrams, Mathew, Åkerlund, Cecilia, Andelic, Nada, Aries, Marcel, Bashford, Tom, Bell, Michael, Bodien, Yelena, Brett, Benjamin, Büki, András, Chesnut, Randall, Citerio, Giuseppe, Clark, David, Clasby, Betony, Cooper, D, Czeiter, Endre, Czosnyka, Marek, Dams-OConnor, Kristen, De Keyser, Véronique, Diaz-Arrastia, Ramon, Ercole, Ari, van Essen, Thomas, Falvey, Éanna, Nelson, David, Nelson, Lindsay, Newcombe, Virginia, Okonkwo, David, Orešič, Matej, Peul, Wilco, Pisică, Dana, Polinder, Suzanne, Ponsford, Jennie, Puybasset, Louis, Raj, Rahul, Robba, Chiara, Røe, Cecilie, Rosand, Jonathan, Schueler, Peter, Sharp, David, Smielewski, Peter, Stein, Murray, von Steinbüchel, Nicole, Stewart, William, Steyerberg, Ewout, Stocchetti, Nino, Temkin, Nancy, Tenovuo, Olli, Theadom, Alice, Thomas, Ilias, Espin, Abel, Turgeon, Alexis, Unterberg, Andreas, Van Praag, Dominique, van Veen, Ernest, Verheyden, Jan, Vyvere, Thijs, Wang, Kevin, Wiegers, Eveline, Williams, W, Wilson, Lindsay, Wisniewski, Stephen, Younsi, Alexander, Figaji, Anthony, Fitzgerald, Melinda, Foreman, Brandon, Gantner, Dashiell, Gao, Guoyi, Giacino, Joseph, Gravesteijn, Benjamin, Guiza, Fabian, Gupta, Deepak, Gurnell, Mark, Haagsma, Juanita, Hammond, Flora, Hawryluk, Gregory, Hutchinson, Peter, van der Jagt, Mathieu, Jain, Sonia, Jain, Swati, Jiang, Ji-Yao, Kent, Hope, Kolias, Angelos, Kompanje, Erwin, Lecky, Fiona, Lingsma, Hester, Maegele, Marc, Majdan, Marek, Markowitz, Amy, McCrea, Michael, Meyfroidt, Geert, Mikolić, Ana, Mondello, Stefania, Yuh, Esther, Zeiler, Frederick, Zeldovich, Marina, Zemek, Roger, Ferguson, Adam, and Mukherjee, Pratik
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Humans ,Brain Injuries ,Traumatic ,Cost of Illness ,Violence ,Sports - Abstract
Traumatic brain injury (TBI) has the highest incidence of all common neurological disorders, and poses a substantial public health burden. TBI is increasingly documented not only as an acute condition but also as a chronic disease with long-term consequences, including an increased risk of late-onset neurodegeneration. The first Lancet Neurology Commission on TBI, published in 2017, called for a concerted effort to tackle the global health problem posed by TBI. Since then, funding agencies have supported research both in high-income countries (HICs) and in low-income and middle-income countries (LMICs). In November 2020, the World Health Assembly, the decision-making body of WHO, passed resolution WHA73.10 for global actions on epilepsy and other neurological disorders, and WHO launched the Decade for Action on Road Safety plan in 2021. New knowledge has been generated by large observational studies, including those conducted under the umbrella of the International Traumatic Brain Injury Research (InTBIR) initiative, established as a collaboration of funding agencies in 2011. InTBIR has also provided a huge stimulus to collaborative research in TBI and has facilitated participation of global partners. The return on investment has been high, but many needs of patients with TBI remain unaddressed. This update to the 2017 Commission presents advances and discusses persisting and new challenges in prevention, clinical care, and research. In LMICs, the occurrence of TBI is driven by road traffic incidents, often involving vulnerable road users such as motorcyclists and pedestrians. In HICs, most TBI is caused by falls, particularly in older people (aged ≥65 years), who often have comorbidities. Risk factors such as frailty and alcohol misuse provide opportunities for targeted prevention actions. Little evidence exists to inform treatment of older patients, who have been commonly excluded from past clinical trials—consequently, appropriate evidence is urgently required. Although increasing age is associated with worse outcomes from TBI, age should not dictate limitations in therapy. However, patients injured by low-energy falls (who are mostly older people) are about 50% less likely to receive critical care or emergency interventions, compared with those injured by high-energy mechanisms, such as road traffic incidents. Mild TBI, defined as a Glasgow Coma sum score of 13–15, comprises most of the TBI cases (over 90%) presenting to hospital. Around 50% of adult patients with mild TBI presenting to hospital do not recover to pre-TBI levels of health by 6 months after their injury. Fewer than 10% of patients discharged after presenting to an emergency department for TBI in Europe currently receive follow-up. Structured follow-up after mild TBI should be considered good practice, and urgent research is needed to identify which patients with mild TBI are at risk for incomplete recovery. The selection of patients for CT is an important triage decision in mild TBI since it allows early identification of lesions that can trigger hospital admission or life-saving surgery. Current decision making for deciding on CT is inefficient, with 90–95% of scanned patients showing no intracranial injury but being subjected to radiation risks. InTBIR studies have shown that measurement of blood-based biomarkers adds value to previously proposed clinical decision rules, holding the potential to improve efficiency while reducing radiation exposure. Increased concentrations of biomarkers in the blood of patients with a normal presentation CT scan suggest structural brain damage, which is seen on MR scanning in up to 30% of patients with mild TBI. Advanced MRI, including diffusion tensor imaging and volumetric analyses, can identify additional injuries not detectable by visual inspection of standard clinical MR images. Thus, the absence of CT abnormalities does not exclude structural damage—an observation relevant to litigation procedures, to management of mild TBI, and when CT scans are insufficient to explain the severity of the clinical condition. Although blood-based protein biomarkers have been shown to have important roles in the evaluation of TBI, most available assays are for research use only. To date, there is only one vendor of such assays with regulatory clearance in Europe and the USA with an indication to rule out the need for CT imaging for patients with suspected TBI. Regulatory clearance is provided for a combination of biomarkers, although evidence is accumulating that a single biomarker can perform as well as a combination. Additional biomarkers and more clinical-use platforms are on the horizon, but cross-platform harmonisation of results is needed. Health-care efficiency would benefit from diversity in providers. In the intensive care setting, automated analysis of blood pressure and intracranial pressure with calculation of derived parameters can help individualise management of TBI. Interest in the identification of subgroups of patients who might benefit more from some specific therapeutic approaches than others represents a welcome shift towards precision medicine. Comparative-effectiveness research to identify best practice has delivered on expectations for providing evidence in support of best practices, both in adult and paediatric patients with TBI. Progress has also been made in improving outcome assessment after TBI. Key instruments have been translated into up to 20 languages and linguistically validated, and are now internationally available for clinical and research use. TBI affects multiple domains of functioning, and outcomes are affected by personal characteristics and life-course events, consistent with a multifactorial bio-psycho-socio-ecological model of TBI, as presented in the US National Academies of Sciences, Engineering, and Medicine (NASEM) 2022 report. Multidimensional assessment is desirable and might be best based on measurement of global functional impairment. More work is required to develop and implement recommendations for multidimensional assessment. Prediction of outcome is relevant to patients and their families, and can facilitate the benchmarking of quality of care. InTBIR studies have identified new building blocks (eg, blood biomarkers and quantitative CT analysis) to refine existing prognostic models. Further improvement in prognostication could come from MRI, genetics, and the integration of dynamic changes in patient status after presentation. Neurotrauma researchers traditionally seek translation of their research findings through publications, clinical guidelines, and industry collaborations. However, to effectively impact clinical care and outcome, interactions are also needed with research funders, regulators, and policy makers, and partnership with patient organisations. Such interactions are increasingly taking place, with exemplars including interactions with the All Party Parliamentary Group on Acquired Brain Injury in the UK, the production of the NASEM report in the USA, and interactions with the US Food and Drug Administration. More interactions should be encouraged, and future discussions with regulators should include debates around consent from patients with acute mental incapacity and data sharing. Data sharing is strongly advocated by funding agencies. From January 2023, the US National Institutes of Health will require upload of research data into public repositories, but the EU requires data controllers to safeguard data security and privacy regulation. The tension between open data-sharing and adherence to privacy regulation could be resolved by cross-dataset analyses on federated platforms, with the data remaining at their original safe location. Tools already exist for conventional statistical analyses on federated platforms, however federated machine learning requires further development. Support for further development of federated platforms, and neuroinformatics more generally, should be a priority. This update to the 2017 Commission presents new insights and challenges across a range of topics around TBI: epidemiology and prevention (section 1); system of care (section 2); clinical management (section 3); characterisation of TBI (section 4); outcome assessment (section 5); prognosis (Section 6); and new directions for acquiring and implementing evidence (section 7). Table 1 summarises key messages from this Commission and proposes recommendations for the way forward to advance research and clinical management of TBI.
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- 2022
38. Accuracy of clinical diagnosis of behavioural variant frontotemporal dementia: a protocol for a systematic review and meta-analysis
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Giancarlo Logroscino, Stefania Mondello, Daniele Urso, and Stefano Giannoni-Luza
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Medicine - Abstract
Introduction Behavioural variant frontotemporal dementia (bvFTD) characterisation has evolved, but diagnosis remains challenging, relying on clinical diagnostic criteria that have undergone revisions over time. In this systematic review, our aims are to evaluate the accuracy of clinical diagnostic criteria for bvFTD by comparing them against pathological diagnoses and determine potential improvement in performance over the years.Methods and analysis This systematic review protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 guidelines and is registered on PROSPERO. We will search four databases (MEDLINE-PubMed, Web of Science, Embase and LILACS) using tailored search terms on May 1st 2024. Inclusion criteria encompass peer-reviewed articles reporting diagnostic parameters or raw data regarding bvFTD clinical diagnosis based on well-defined criteria. Screening and selection of relevant articles will be independently performed by two reviewers using the Covidence systematic review manager. Discrepancies will be resolved by a third researcher. Pathologic and genetic diagnosis will be the main gold standard, but we will also consider refined diagnoses after a follow-up period. Data will be collected on study design, baseline demographics and sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy. Study quality will be assessed with Quality Assessment of Diagnostic Accuracy Studies-2. If possible, we will conduct a meta-analysis using bivariate random-effect models. Subgroup analyses will consider study settings, gold standards, disease stages and bias.Ethics and dissemination Ethics approval will not be needed because the data used in this systematic review will be extracted from published studies. Findings will be disseminated through peer-reviewed publications and presentations at relevant scientific conferences, potentially enhancing our understanding of bvFTD clinical diagnosis reliability and guiding future criteria refinements.PROSPERO registration number CRD42023389063.
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- 2024
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39. Corrigendum: Time-Trends in Air Pollution Impact on Health in Italy, 1990–2019: An Analysis from the Global Burden of Disease Study 2019
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Sara Conti, Carla Fornari, Pietro Ferrara, Ippazio C. Antonazzo, Fabiana Madotto, Eugenio Traini, Miriam Levi, Achille Cernigliaro, Benedetta Armocida, Nicola L. Bragazzi, Ennio Cadum, Michele Carugno, Giacomo Crotti, Silvia Deandrea, Paolo A. Cortesi, Davide Guido, Ivo Iavicoli, Sergio Iavicoli, Carlo La Vecchia, Paolo Lauriola, Paola Michelozzi, Salvatore Scondotto, Massimo Stafoggia, Francesco S. Violante, Cristiana Abbafati, Luciana Albano, Francesco Barone-Adesi, Antonio Biondi, Cristina Bosetti, Danilo Buonsenso, Giulia Carreras, Giulio Castelpietra, Alberico Catapano, Maria S. Cattaruzza, Barbara Corso, Giovanni Damiani, Francesco Esposito, Silvano Gallus, Davide Golinelli, Simon I. Hay, Gaetano Isola, Caterina Ledda, Stefania Mondello, Paolo Pedersini, Umberto Pensato, Norberto Perico, Giuseppe Remuzzi, Francesco Sanmarchi, Rocco Santoro, Biagio Simonetti, Brigid Unim, Marco Vacante, Massimiliano Veroux, Jorge H. Villafañe, Lorenzo Monasta, and Lorenzo G. Mantovani
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air pollution ,particulate matter ,ozone ,global burden of disease ,air quality regulations ,Public aspects of medicine ,RA1-1270 - Published
- 2024
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40. Juniperus oxycedrus leaves and berries extracts: HPLC-PDA-ESI/MS2 phenolic characterization and in vitro anti-inflammatory effects
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Mohamed Reda Kachmar, Yassine Oulad El Majdoub, Andreia P. Oliveira, Aziz Bouymajane, Hanae Naceiri Mrabti, Toufik Bouddine, Nora Mir, Nidal Naceiri Mrabti, Hajji Lhoussain, Zoubida Haloui, Alessia Tropea, Francesco Cacciola, Luigi Mondello, Paula B. Andrade, and Said Chakir
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Juniperus oxycedrus ,Polyphenols ,Food ,Liquid chromatography ,Anti-inflammatory ,Other systems of medicine ,RZ201-999 - Abstract
Background: Inflammation is a natural response of the body to tissue injury or infection, but chronic inflammation can contribute to the development of various diseases. Therefore, finding effective ways to reduce inflammation is of great interest to researchers and healthcare providers. The aim of the study was the elucidation of the phenolic profile from J. oxycedrus leaves and berries followed by in vitro antioxidant and anti-inflammatory assays. Despite the existence of some works on this species, most of these researchers focus their attention on cade oil and only few were interested to study leaves and berries extracts. Methods: HPLC-DAD-ESI/MS2 was used for their characterization of the phenolic profile whereas spectrophotometric microassays in non-cellular and cellular systems (RAW 264.7 macrophages cell line) was assessed for their in vitro antioxidant and anti-inflammatory potentials. Results: Up to twenty-one polyphenolic compounds were positively identified in both extracts. Both leaves and berries extracts showed strong antioxidant capacity to scavenge O2●, with IC50 values of 22.86 ± 2.40 and 122.62 ± 9.42 µg/mL. Moreover, both revealed to have potential to inhibit 5-lipoxygenase in a dose-dependent way, being leaves the most effective vegetal material. Conclusion: The results suggest that J. oxycedrus leaves and berries could be considered exquisite sources of bioactive molecules for a potential further application in the food and pharmaceutical industries.
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- 2024
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41. The Use of Biofluid Markers to Evaluate the Consequences of Sport-Related Subconcussive Head Impact Exposure: A Scoping Review
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Liivia-Mari Lember, Michail Ntikas, Stefania Mondello, Lindsay Wilson, Thomas G. Di Virgilio, Angus M. Hunter, Firas Kobeissy, Yehia Mechref, David I. Donaldson, and Magdalena Ietswaart
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Traumatic brain injury ,Diagnostics ,Neurodegenerative disease ,Fluid biomarkers ,Contact sport ,Heading ,Sports medicine ,RC1200-1245 - Abstract
Abstract Background Amidst growing concern about the safety of sport-related repetitive subconcussive head impacts (RSHI), biofluid markers may provide sensitive, informative, and practical assessment of the effects of RSHI exposure. Objective This scoping review aimed to systematically examine the extent, nature, and quality of available evidence from studies investigating the effects of RSHI on biofluid markers, to identify gaps and to formulate guidelines to inform future research. Methods PRISMA extension for Scoping Reviews guidelines were adhered to. The protocol was pre-registered through publication. MEDLINE, Scopus, SPORTDiscus, CINAHL, PsycINFO, Cochrane Library, OpenGrey, and two clinical trial registries were searched (until March 30, 2022) using descriptors for subconcussive head impacts, biomarkers, and contact sports. Included studies were assessed for risk of bias and quality. Results Seventy-nine research publications were included in the review. Forty-nine studies assessed the acute effects, 23 semi-acute and 26 long-term effects of RSHI exposure. The most studied sports were American football, boxing, and soccer, and the most investigated markers were (in descending order): S100 calcium-binding protein beta (S100B), tau, neurofilament light (NfL), glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), brain-derived neurotrophic factor (BDNF), phosphorylated tau (p-tau), ubiquitin C-terminal hydrolase L1 (UCH-L1), and hormones. High or moderate bias was found in most studies, and marker-specific conclusions were subject to heterogeneous and limited evidence. Although the evidence is weak, some biofluid markers—such as NfL—appeared to show promise. More markedly, S100B was found to be problematic when evaluating the effects of RSHI in sport. Conclusion Considering the limitations of the evidence base revealed by this first review dedicated to systematically scoping the evidence of biofluid marker levels following RSHI exposure, the field is evidently still in its infancy. As a result, any recommendation and application is premature. Although some markers show promise for the assessment of brain health following RSHI exposure, future large standardized and better-controlled studies are needed to determine biofluid markers’ utility.
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- 2024
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42. Current hospital policies on breastfeeding: a survey from Italy
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Riccardo Davanzo, Laura Travan, Maria Lorella Giannì, Giuseppe Giordano, Silvia Perugi, Mariella Baldassarre, Antonella Soldi, Lorenzo Colombo, Isabella Mondello, Michela Pandullo, Alessia Ferrara, Elena Scarpato, and Guglielmo Salvatori
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Breastfeeding ,Policy ,Hospital ,Survey ,Baby-Friendly Hospital Initiative ,Pediatrics ,RJ1-570 - Abstract
Abstract Background The availability of an appropriate newborn feeding policy is an essential component of the promotion of breastfeeding in health facilities. The Italian Society of Neonatology (SIN) and the Italian Society of Paediatrics (SIP) have run an online survey among Maternity Hospitals to explore the existing breastfeeding policies and their characteristics. Methods Between February and April 2023, an online survey was carried out among 110 Italian maternity hospitals with a Neonatal Intensive Care Unit (NICU). Results Forty-nine Maternity Hospitals completed the online questionnaire. Twenty out of 49 (40.8%) reported to have a breastfeeding policy. When a policy is available, its quality appears to be suboptimal because of lack of inclusion of a family representative in the policy working group, limited options for translating breastfeeding policy into minority languages, lack of periodic assessment of their implementation. Conclusion Currently, only a limited number of Italian Maternity Hospitals have developed a breastfeeding policy. Additional efforts are needed for their improvement as well as implementation.
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- 2024
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43. Postmortem Detection of 'Clinically Undiagnosed' Diffuse Large B-Cell Lymphoma: Gross and Microscopic Findings
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Vincenzo Cianci, Daniela Sapienza, Giovanni Bartoloni, Alessio Cianci, Annalisa Cracò, Fausto Omero, Patrizia Gualniera, Alessio Asmundo, and Cristina Mondello
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forensic pathology ,forensic autopsy ,large B-cell lymphoma ,AIDS ,postmortem diagnosis ,Medicine (General) ,R5-920 - Abstract
Diffuse large B-cell lymphoma is considered the most found non-Hodgkin lymphoma in adults. Diffuse large B-cell lymphoma, which also occurs in sporadic forms, is associated with some pathological conditions, including human immunodeficiency virus infection, especially if it progresses to AIDS. The authors report the case of a 45-year-old man with AIDS in whom a postmortem diagnosis of diffuse large B-cell lymphoma was performed. The proposed images document extensive pluri-visceral involvement, already visible macroscopically, and subsequently confirmed through histological examination.
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- 2024
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44. microRNAs as New Biomolecular Markers to Estimate Time since Death: A Systematic Review
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Vincenzo Cianci, Cristina Mondello, Daniela Sapienza, Maria Cristina Guerrera, Alessio Cianci, Annalisa Cracò, Francesco Luppino, Vittorio Gioffrè, Patrizia Gualniera, Alessio Asmundo, and Antonino Germanà
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PMI estimation ,post-mortem interval estimation ,RNA degradation ,microRNA degradation ,miRNA degradation ,forensic molecular pathology ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Estimating the post-mortem interval is still one of the most complex challenges in forensics. In fact, the main tools currently used are burdened by numerous limitations, which sometimes allow the time of death to be placed only within too large time intervals. In recent years, researchers have tried to identify new tools to try to narrow down the interval within which to place the time of death; among these, the analysis of microRNAs seems to be promising. An evidence-based systematic review of the literature has been conducted to evaluate the state of the art of knowledge, focusing on the potential correlation between miRNA degradation and PMI estimation. The research has been performed using the electronic databases PubMed, Scopus, and WOS. The results allowed us to highlight the usefulness of miRNAs both as markers for PMI estimation and for normalization, especially due to their stability. In fact, some miRNAs remain particularly stable for long periods and in different tissues, while others degrade faster. Furthermore, there are numerous factors capable of influencing the behavior of these molecules, among which the type of tissue, the cause of death, and the circadian rhythm appear to be the most relevant. Despite the promising results of the few articles present in the literature, because of the numerous limitations they are burdened by, further research is still necessary to achieve more solid and shareable results.
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- 2024
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45. T-cell phenotype including CD57+ T follicular helper cells in the tumor microenvironment correlate with a poor outcome in follicular lymphoma
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Yang, Zhi-Zhang, Kim, Hyo Jin, Wu, Hongyan, Tang, Xinyi, Yu, Yue, Krull, Jordan, Larson, Daniel P., Moore, Raymond M., Maurer, Matthew J., Pavelko, Kevin D., Jalali, Shahrzad, Pritchett, Joshua C., Mudappathi, Rekha, Wang, Junwen, Villasboas, Jose C., Mondello, Patrizia, Novak, Anne J., and Ansell, Stephen M.
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- 2023
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46. Comprehensive two-dimensional liquid chromatography
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Mondello, Luigi, Dugo, Paola, Donato, Paola, Herrero, Miguel, Montero, Lidia, and Schmitz, Oliver J.
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- 2023
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47. Flowering phenophases influence the antibacterial and anti-biofilm effects of Thymus vulgaris L. essential oil
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Bakó, Csongor, Balázs, Viktória Lilla, Kerekes, Erika, Kocsis, Béla, Nagy, Dávid U., Szabó, Péter, Micalizzi, Giuseppe, Mondello, Luigi, Krisch, Judit, Pethő, Dóra, and Horváth, Györgyi
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- 2023
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48. Universally irreducible subvarieties of Siegel moduli spaces
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Mondello, Gabriele and Manni, Riccardo Salvati
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Mathematics - Algebraic Geometry ,Mathematics - Complex Variables ,14F35, 32S50, 11F46 - Abstract
A subvariety of a quasi-projective complex variety $X$ is called ``universally irreducible'' if its preimage inside the universal cover of $X$ is irreducible. In this paper we investigate sufficient conditions for universal irreducibility. We consider in detail complete intersection subvarieties of small codimension inside Siegel moduli spaces of any finite level. Moreover we show that, for $g\geq 3$, every Siegel modular form is the product of finitely many irreducible analytic functions on the Siegel upper half-space $\mathbb{H}_g$. We also discuss the special case of singular theta series of weight $\frac{1}{2}$ and of Schottky forms., Comment: 37 pages. Final version. Accepted for publication on Crelle
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- 2021
49. T-cell phenotype including CD57+ T follicular helper cells in the tumor microenvironment correlate with a poor outcome in follicular lymphoma
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Zhi-Zhang Yang, Hyo Jin Kim, Hongyan Wu, Xinyi Tang, Yue Yu, Jordan Krull, Daniel P. Larson, Raymond M. Moore, Matthew J. Maurer, Kevin D. Pavelko, Shahrzad Jalali, Joshua C. Pritchett, Rekha Mudappathi, Junwen Wang, Jose C. Villasboas, Patrizia Mondello, Anne J. Novak, and Stephen M. Ansell
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract T-lymphocytes are prevalent in the tumor microenvironment of follicular lymphoma (FL). However, the phenotype of T-cells may vary, and the prevalence of certain T-cell subsets may influence tumor biology and patient survival. We therefore analyzed a cohort of 82 FL patients using CyTOF to determine whether specific T-cell phenotypes were associated with distinct tumor microenvironments and patient outcome. We identified four immune subgroups with differing T-cell phenotypes and the prevalence of certain T-cell subsets was associated with patient survival. Patients with increased T cells with early differentiation stage tended to have a significantly better survival than patients with increased T-cells of late differentiation stage. Specifically, CD57+ TFH cells, with a late-stage differentiation phenotype, were significantly more abundant in FL patients who had early disease progression and therefore correlated with an inferior survival. Single cell analysis (CITE-seq) revealed that CD57+ TFH cells exhibited a substantially different transcriptome from CD57− TFH cells with upregulation of inflammatory pathways, evidence of immune exhaustion and susceptibility to apoptosis. Taken together, our results show that different tumor microenvironments among FL patients are associated with variable T-cell phenotypes and an increased prevalence of CD57+ TFH cells is associated with poor patient survival.
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- 2023
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50. Characterization of immune exhaustion and suppression in the tumor microenvironment of splenic marginal zone lymphoma
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Anagnostou, Theodora, Yang, Zhi-Zhang, Jalali, Shahrzad, Kim, Hyo Jin, Larson, Daniel P., Tang, Xinyi, Yu, Yue, Pritchett, Joshua C., Bisneto, Jose Villasboas, Price-Troska, Tammy L., Mondello, Patrizia, Novak, Anne J., and Ansell, Stephen M.
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- 2023
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