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2. Ceramide present in cholangiocarcinoma-derived extracellular vesicle induces a pro-inflammatory state in monocytes

Author

Oliviero, Barbara, Dei Cas, Michele, Zulueta, Aida, Maiello, Roberta, Villa, Alessandro, Martinelli, Carla, Del Favero, Elena, Falleni, Monica, Montavoci, Linda, Varchetta, Stefania, Mele, Dalila, Donadon, Matteo, Soldani, Cristiana, Franceschini, Barbara, Maestri, Marcello, Piccolo, Gaetano, Barabino, Matteo, Bianchi, Paolo Pietro, Banales, Jesus M., Mantovani, Stefania, Mondelli, Mario U., and Caretti, Anna

Published
2023
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6. Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patients

Author

Mantovani, Stefania, Daga, Sergio, Fallerini, Chiara, Baldassarri, Margherita, Benetti, Elisa, Picchiotti, Nicola, Fava, Francesca, Gallì, Anna, Zibellini, Silvia, Bruttini, Mirella, Palmieri, Maria, Croci, Susanna, Amitrano, Sara, Alaverdian, Diana, Capitani, Katia, Furini, Simone, Mari, Francesca, Meloni, Ilaria, Frullanti, Elisa, Mondelli, Mario U., and Renieri, Alessandra

Published
2022
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7. Long‐term dynamics of natural killer cells in response to SARS‐CoV‐2 vaccination: Persistently enhanced activity postvaccination

Author

Mele, Dalila, primary, Ottolini, Sabrina, additional, Lombardi, Andrea, additional, Conteianni, Daniela, additional, Bandera, Alessandra, additional, Oliviero, Barbara, additional, Mantovani, Stefania, additional, Cassaniti, Irene, additional, Baldanti, Fausto, additional, Gori, Andrea, additional, Mondelli, Mario U., additional, and Varchetta, Stefania, additional

Published
2024
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9. Unique immunological profile in patients with COVID-19

Author

Varchetta, Stefania, Mele, Dalila, Oliviero, Barbara, Mantovani, Stefania, Ludovisi, Serena, Cerino, Antonella, Bruno, Raffaele, Castelli, Alberto, Mosconi, Mario, Vecchia, Marco, Roda, Silvia, Sachs, Michele, Klersy, Catherine, and Mondelli, Mario U.

Published
2021
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14. VDAC1 selective molecules promote patients’-derived cancer organoids death through mitochondrial-dependent metabolic interference

Author

Conti Nibali, Stefano, primary, De Siervi, Silvia, additional, Luchinat, Enrico, additional, Magrì, Andrea, additional, Brocca, Lorenza, additional, Mantovani, Stefania, additional, Oliviero, Barbara, additional, Mondelli, Mario U., additional, De Pinto, Vito, additional, Turato, Cristian, additional, Arrigoni, Cristina, additional, and Lolicato, Marco, additional

Published
2023
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19. Hepatitis C Virus and the Host: A Mutual Endurance Leaving Indelible Scars in the Host's Immunity.

Author

Mondelli, Mario U., Ottolini, Sabrina, Oliviero, Barbara, Mantovani, Stefania, Cerino, Antonella, Mele, Dalila, and Varchetta, Stefania

Subjects
*HEPATITIS C virus, *T-cell exhaustion, *IMMUNITY, *VACCINE effectiveness, *IMMUNE response
Abstract

Hepatitis C virus (HCV) has spread worldwide, and it is responsible for potentially severe chronic liver disease and primary liver cancer. Chronic infection remains for life if not spontaneously eliminated and viral persistence profoundly impairs the efficiency of the host's immunity. Attempts have been made to develop an effective vaccine, but efficacy trials have met with failure. The availability of highly efficacious direct-acting antivirals (DAA) has created hope for the progressive elimination of chronic HCV infections; however, this approach requires a monumental global effort. HCV elicits a prompt innate immune response in the host, characterized by a robust production of interferon-α (IFN-α), although interference in IFN-α signaling by HCV proteins may curb this effect. The late appearance of largely ineffective neutralizing antibodies and the progressive exhaustion of T cells, particularly CD8 T cells, result in the inability to eradicate the virus in most infected patients. Moreover, an HCV cure resulting from DAA treatment does not completely restore the normal immunologic homeostasis. Here, we discuss the main immunological features of immune responses to HCV and the epigenetic scars that chronic viral persistence leaves behind. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Hepatitis C

Author

Mondelli, Mario U., Varchetta, Stefania, Negro, Francesco, Gershwin, M. Eric, editor, Vierling, John M., editor, and Manns, Michael P., editor

Published
2014
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24. Impact of COVID-19 on the liver and on the care of patients with chronic liver disease, hepatobiliary cancer, and liver transplantation: An updated EASL position paper

Author

Marjot, Thomas, primary, Eberhardt, Christiane S., additional, Boettler, Tobias, additional, Belli, Luca S., additional, Berenguer, Marina, additional, Buti, Maria, additional, Jalan, Rajiv, additional, Mondelli, Mario U., additional, Moreau, Richard, additional, Shouval, Daniel, additional, Berg, Thomas, additional, and Cornberg, Markus, additional

Published
2022
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26. Defective DNAM-1 Dependent Cytotoxicity in Hepatocellular Carcinoma-Infiltrating NK Cells

Author

Mantovani, Stefania, primary, Varchetta, Stefania, additional, Mele, Dalila, additional, Maiello, Roberta, additional, Donadon, Matteo, additional, Soldani, Cristiana, additional, Franceschini, Barbara, additional, Torzilli, Guido, additional, Tartaglia, Giuseppe, additional, Maestri, Marcello, additional, Piccolo, Gaetano, additional, Barabino, Matteo, additional, Opocher, Enrico, additional, Bernuzzi, Stefano, additional, Mondelli, Mario U., additional, and Oliviero, Barbara, additional

Published
2022
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28. TLRs: Innate Immune Sentries against SARS-CoV-2 Infection.

Author

Mantovani, Stefania, Oliviero, Barbara, Varchetta, Stefania, Renieri, Alessandra, and Mondelli, Mario U.

Subjects
SARS-CoV-2, COVID-19, VIRUS diseases
Abstract

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been responsible for a devastating pandemic since March 2020. Toll-like receptors (TLRs), crucial components in the initiation of innate immune responses to different pathogens, trigger the downstream production of pro-inflammatory cytokines, interferons, and other mediators. It has been demonstrated that they contribute to the dysregulated immune response observed in patients with severe COVID-19. TLR2, TLR3, TLR4 and TLR7 have been associated with COVID-19 severity. Here, we review the role of TLRs in the etiology and pathogenesis of COVID-19, including TLR7 and TLR3 rare variants, the L412F polymorphism in TLR3 that negatively regulates anti-SARS-CoV-2 immune responses, the TLR3-related cellular senescence, the interaction of TLR2 and TLR4 with SARS-CoV-2 proteins and implication of TLR2 in NET formation by SARS-CoV-2. The activation of TLRs contributes to viral clearance and disease resolution. However, TLRs may represent a double-edged sword which may elicit dysregulated immune signaling, leading to the production of proinflammatory mediators, resulting in severe disease. TLR-dependent excessive inflammation and TLR-dependent antiviral response may tip the balance towards the former or the latter, altering the equilibrium that drives the severity of disease. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Carriers of ADAMTS13 Rare Variants Are at High Risk of Life-Threatening COVID-19

Author

Zguro, Kristina, Baldassarri, Margherita, Fava, Francesca, Beligni, Giada, Daga, Sergio, Leoncini, Roberto, Galasso, Lucrezia, Cirianni, Michele, Rusconi, Stefano, Siano, Matteo, Francisci, Daniela, Schiaroli, Elisabetta, Luchi, Sauro, Morelli, Giovanna, Martinelli, Enrico, Girardis, Massimo, Busani, Stefano, Parisi, Saverio Giuseppe, Panese, Sandro, Piscopo, Carmelo, Capasso, Mario, Tacconi, Danilo, Spertilli Raffaelli, Chiara, Giliberti, Annarita, Gori, Giulia, Katsikis, Peter D, Lorubbio, Maria, Calzoni, Paola, Ognibene, Agostino, Bocchia, Monica, Tozzi, Monica, Bucalossi, Alessandro, Marotta, Giuseppe, Furini, Simone, Gen-Covid Multicenter Study, Null, Renieri, Alessandra, Fallerini, Chiara, GEN-COVID Multicenter Study, Mari, Francesca, Bruttini, Mirella, Meloni, Ilaria, Croci, Susanna, Gabriella, Doddato, Serio, VIOLA BIANCA, Mirjam, Lista, Maffeo, Debora, Pasquinelli, Elena, Ludovica, Mercuri, Brunelli, Giulia, Rossella, Tita, Maria Antonietta Mencarelli, LO RIZZO, Caterina, Pinto, ANNA MARIA, Ariani, Francesca, Montagnani, Francesca, Tumbarello, Mario, Ilaria, Rancan, Massimiliano, Fabbiani, Bargagli, Elena, Bergantini, Laura, D'Alessandro, Miriana, Cameli, Paolo, Bennett, David, Federico, Anedda, Simona, Marcantonio, Scolletta, Sabino, Franchi, Federico, Mazzei, MARIA ANTONIETTA, Susanna, Guerrini, Edoardo, Conticini, Cantarini, Luca, Frediani, Bruno, Marco, Feri, Alice, Donati, Raffaele, Scala, Luca, Guidelli, Genni, Spargi, Marta, Corridi, Cesira, Nencioni, Leonardo, Croci, Gian Piero Caldarelli, Davide, Romani, Paolo, Piacentini, Maria, Bandini, Elena, Desanctis, Silvia, Cappelli, Anna, Canaccini, Agnese, Verzuri, Valentina, Anemoli, Manola, Pisani, Alessandro, Pancrazzi, Massimo, Vaghi, Antonella D’Arminio Monforte, Federica Gaia Miraglia, Mondelli, Mario U., Stefania, Mantovani, Raffaele, Bruno, Marco, Vecchia, Marcello, Maffezzoni, Sophie, Venturelli, Andrea, Cossarizza, Andrea, Antinori, Alessandra, Vergori, Arianna, Emiliozzi, Arianna, Gabrieli, Agostino, Riva, Andrea, Tommasi, Pier Giorgio Scotton, Francesca, Andretta, Stefano, Baratti, Renzo, Scaggiante, Francesca, Gatti, Francesco, Castelli, Eugenia, Quiros-Roldan, Melania Degli Antoni, Isabella, Zanella, Matteo della Monica, Roberta, Russo, Immacolata, Andolfo, Achille, Iolascon, Giuseppe, Fiorentino, Massimo, Carella, Marco, Castori, Giuseppe, Merla, Gabriella Maria Squeo, Filippo, Aucella, Pamela, Raggi, Rita, Perna, Matteo, Bassetti, Antonio Di Biagio, Maurizio, Sanguinetti, Luca, Masucci, Alessandra, Guarnaccia, Valente, Serafina, Alex Di Florio, Mandala', Marco, Giorli, Alessia, Salerni, Lorenzo, Patrizia, Zucchi, Pierpaolo, Parravicini, Elisabetta, Menatti, Tullio, Trotta, Ferdinando, Giannattasio, Gabriella, Coiro, Fabio, Lena, Gianluca, Lacerenza, Cristina, Mussini, Luisa, Tavecchia, Lia, Crotti, Gianfranco, Parati, Roberto, Menè, Maurizio, Sanarico, Gori, Marco, Nicola, Picchiotti, Francesco, Raimondi, Alessandra, Stella, Filippo, Biscarini, Tiziana, Bachetti, Maria Teresa La Rovere, Maurizio, Bussotti, Serena, Ludovisi, Katia, Capitani, Chiara, Gabbi, Simona, Dei, Sabrina, Ravaglia, Rosangela, Artuso, Elena, Andreucci, Angelica, Pagliazzi, Erika, Fiorentini, Antonio, Perrella, Francesco, Bianchi, Paola, Bergomi, Emanuele, Catena, Riccardo, Colombo, Paola, Petrocelli, Sarah, Iacopini, Sara, Modica, Silvia, Baroni, Giulia, Micheli, Marco, Falcone, Giusy, Tiseo, Chiara, Barbieri, Tommaso, Matucci, Davide, Grassi, Claudio, Ferri, Franco, Marinangeli, Francesco, Brancati, Antonella, Vincenti, Valentina, Borgo, Stefania, Lombardi, Mirco, Lenzi, Massimo Antonio Di Pietro, Francesca, Vichi, Benedetta, Romanin, Letizia, Attala, Cecilia, Costa, Andrea, Gabbuti, Alessio, Bellucci, Marta, Colaneri, Patrizia, Casprini, Cristoforo, Pomara, Massimiliano, Esposito, Marco Antonio Bellini, Zguro, Kristina, Baldassarri, Margherita, Fava, Francesca, Beligni, Giada, Daga, Sergio, Leoncini, Roberto, Galasso, Lucrezia, Cirianni, Michele, Rusconi, Stefano, Siano, Matteo, Francisci, Daniela, Schiaroli, Elisabetta, Luchi, Sauro, Morelli, Giovanna, Martinelli, Enrico, Girardis, Massimo, Busani, Stefano, Parisi, Saverio Giuseppe, Panese, Sandro, Piscopo, Carmelo, Capasso, Mario, Tacconi, Danilo, Spertilli Raffaelli, Chiara, Giliberti, Annarita, Gori, Giulia, Katsikis, Peter D, Lorubbio, Maria, Calzoni, Paola, Ognibene, Agostino, Bocchia, Monica, Tozzi, Monica, Bucalossi, Alessandro, Marotta, Giuseppe, Furini, Simone, Gen-Covid Multicenter Study, Null, Renieri, Alessandra, Fallerini, Chiara, Gen-Covid Multicenter Study, null, and Immunology

Subjects
Thrombotic Thrombocytopenic, Purpura, Thrombotic Thrombocytopenic, SARS-CoV-2, COVID-19, ADAMTS13, thromboembolism, add-on therapy, ADAMTS13 Protein, ADAM Proteins, Infectious Diseases, SDG 3 - Good Health and Well-being, Virology, von Willebrand Factor, Humans, Purpura
Abstract

Thrombosis of small and large vessels is reported as a key player in COVID-19 severity. However, host genetic determinants of this susceptibility are still unclear. Congenital Thrombotic Thrombocytopenic Purpura is a severe autosomal recessive disorder characterized by uncleaved ultra-large vWF and thrombotic microangiopathy, frequently triggered by infections. Carriers are reported to be asymptomatic. Exome analysis of about 3000 SARS-CoV-2 infected subjects of different severities, belonging to the GEN-COVID cohort, revealed the specific role of vWF cleaving enzyme ADAMTS13 (A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 13). We report here that ultra-rare variants in a heterozygous state lead to a rare form of COVID-19 characterized by hyper-inflammation signs, which segregates in families as an autosomal dominant disorder conditioned by SARS-CoV-2 infection, sex, and age. This has clinical relevance due to the availability of drugs such as Caplacizumab, which inhibits vWF–platelet interaction, and Crizanlizumab, which, by inhibiting P-selectin binding to its ligands, prevents leukocyte recruitment and platelet aggregation at the site of vascular damage.

Published
2022

30. Early and Polyantigenic CD4 T Cell Responses Correlate with Mild Disease in Acute COVID-19 Donors

Author

Tarke, Alison, primary, Potesta, Marina, additional, Varchetta, Stefania, additional, Fenoglio, Daniela, additional, Iannetta, Marco, additional, Sarmati, Loredana, additional, Mele, Dalila, additional, Dentone, Chiara, additional, Bassetti, Matteo, additional, Montesano, Carla, additional, Mondelli, Mario U., additional, Filaci, Gilberto, additional, Grifoni, Alba, additional, and Sette, Alessandro, additional

Published
2022
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34. MICA/B-targeted antibody promotes NK cell–driven tumor immunity in patients with intrahepatic cholangiocarcinoma

Author

Oliviero, Barbara, primary, Varchetta, Stefania, additional, Mele, Dalila, additional, Pessino, Greta, additional, Maiello, Roberta, additional, Falleni, Monica, additional, Tosi, Delfina, additional, Donadon, Matteo, additional, Soldani, Cristiana, additional, Franceschini, Barbara, additional, Torzilli, Guido, additional, Piccolo, Gaetano, additional, Barabino, Matteo, additional, Opocher, Enrico, additional, Maestri, Marcello, additional, Bernuzzi, Stefano, additional, Wucherpfennig, Kai W., additional, Mondelli, Mario U., additional, and Mantovani, Stefania, additional

Published
2022
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35. High Frequencies of Functional Virus-Specific CD4+ T Cells in SARS-CoV-2 Subjects With Olfactory and Taste Disorders

Author

Mele, Dalila, primary, Calastri, Anna, additional, Maiorano, Eugenia, additional, Cerino, Antonella, additional, Sachs, Michele, additional, Oliviero, Barbara, additional, Mantovani, Stefania, additional, Baldanti, Fausto, additional, Bruno, Raffaele, additional, Benazzo, Marco, additional, Grifoni, Alba, additional, Sette, Alessandro, additional, Mondelli, Mario U., additional, and Varchetta, Stefania, additional

Published
2021
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40. A new algorithm shows superior ability to discriminate liver fibrosis stages in chronic hepatitis C

Author

Varchetta, Stefania, primary, Mele, Dalila, additional, D'Ambrosio, Roberta, additional, Perbellini, Riccardo, additional, Lombardi, Andrea, additional, Rojas, Angela, additional, Paolucci, Stefania, additional, Baldanti, Fausto, additional, Oliviero, Barbara, additional, Mantovani, Stefania, additional, Tinelli, Carmine, additional, De Silvestri, Annalisa, additional, Romero Gomez, Manuel, additional, Lampertico, Pietro, additional, and Mondelli, Mario U., additional

Published
2021
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44. PD-L1 negatively regulates [CD4.sup.+][CD25.sup.+][Foxp3.sup.+] Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV

Author

Franceschini, Debora, Paroli, Marino, Francavilla, Vittorio, Videtta, Melissa, Morrone, Stefania, Labbadia, Giancarlo, Cerino, Antonella, Mondelli, Mario U., and Barnaba, Vincenzo

Subjects
T cells -- Research, T cells -- Physiological aspects, Immune response -- Physiological aspects, Immune response -- Research, Phosphorylation -- Research, Hepatitis C virus -- Research
Abstract

[CD4.sup.+][CD25.sup.+][Foxp3.sup.+] Tregs suppress autoimmune responses. In addition, they limit T cell responses during chronic infection, thereby minimizing T cell--dependent immunopathology. We sought to investigate how Tregs are regulated in the livers of patients chronically infected with HCV, where they control the balance between an adequate protective immune response and suppression of immunopathology. We found that, despite accumulating and proliferating at sites of infection in the livers of patients chronically infected with HCV, Tregs were relatively less expanded than [CD4.sup.+][CD25.sup.+][Foxp3.sup.-] effector T cells. The relative lower expansion of intrahepatic Tregs coincided with their upregulation of programmed death-1 (PD-1). PD-1 expression inversely correlated with both Treg proliferation and clinical markers of immune suppression in vivo. Consistent with the possibility that PD-1 controls Tregs, blockade of the interaction between PD-1 and programmed death-1 ligand 1 (PD-L1) enhanced the in vitro expansion and function of Tregs isolated from the livers of patients chronically infected with HCV. Blockade of the interaction between PD-L1 and B7.1 also improved the proliferation of these cells. Interestingly, both PD-1 and phosphorylated STAT-5 were overexpressed in intrahepatic Tregs in a parallel fashion in steady disease conditions, and in an alternate-fluctuating fashion during the course of severe hepatitis reactivation. Notably, PD-L1 blockade upregulated STAT-5 phosphorylation in Tregs ex vivo. These data suggest that PD-L1 negatively regulates Tregs at sites of chronic inflammation by controlling STAT-5 phosphorylation., Introduction [CD4.sup.+][CD25.sup.+][Foxp3.sup.+] Tregs are essential in maintaining peripheral immunological self tolerance (1-11). Natural Tregs develop intrathymically in response to specific combinations of TCR and costimulatory signals and represent about 5%-15% [...]

Published
2009

45. SARS-CoV-2 RNA contamination of inanimate surfaces and virus viability in a health care emergency unit

Author

Colaneri, Marta, Seminari, Elena, Novati, Stefano, Asperges, Erika, Biscarini, Simona, Piralla, Antonio, Percivalle, Elena, Cassaniti, Irene, Baldanti, Fausto, Bruno, Raffaele, and Mondelli, Mario U.

Subjects
Microbial Viability, environmental contamination, SARS-CoV-2, Reverse Transcriptase Polymerase Chain Reaction, COVID-19, surfaces, RNA-Dependent RNA Polymerase, Article, Betacoronavirus, Coronavirus Envelope Proteins, Intensive Care Units, Viral Proteins, Viral Envelope Proteins, Fomites, Chlorocebus aethiops, Animals, Equipment Contamination, Humans, Vero Cells
Abstract

Objectives To detect possible SARS-CoV-2 RNA contamination of inanimate surfaces in areas at high risk of aerosol formation by patients with COVID-19. Methods Sampling was performed in the emergency unit and the sub-intensive care ward. SARS-CoV-2 RNA was extracted from swabbed surfaces and objects and subjected to real-time reverse transcriptase–polymerase chain reaction (RT-PCR) targeting RNA-dependent RNA polymerase and E genes. Virus isolation from positive samples was attempted in vitro on Vero E6 cells. Results Twenty-six samples were collected and only two were positive for low-level SARS-CoV-2 RNA, both collected on the external surface of Continuous Positive Airway Pressure (CPAP) helmets. All transport media were inoculated onto susceptible cells, however, none induced a cytopathic effect on day 7 of culture. Conclusions Even though daily contact with inanimate surfaces and patient fomites in contaminated areas may be a medium of infection, our data obtained in real life conditions suggest that it might be less extensive than hitherto recognized.

Published
2020

46. SARS Cov-2 infection in a renal-transplanted patient: A case report

Author

Seminari, Elena, Colaneri, Marta, Sambo, Margherita, Gallazzi, Ilaria, Di Matteo, Angela, Roda, Silvia, Bruno, Raffaele, Mondelli, Mario U., Brunetti, Enrico, Maiocchi, Laura, Zuccaro, Valentina, Pagnucco, Layla, Mariani, Bianca, Ludovisi, Serena, Lissandrin, Raffaella, Parisi, Aldo, Sacchi, Paolo, Patruno, Savino F. A., Michelone, Giuseppe, Gulminetti, Roberto, Zanaboni, Domenico, Novati, Stefano, Maserati, Renato, Orsolini, Paolo, Vecchia, Marco, Sciarra, Marco, Asperges, Erika, Di Filippo, Alessandro, Biscarini, Simona, Lupi, Matteo, Pieri, Teresa C., Sachs, Michele, Valsecchi, Pietro, Perlini, Stefano, Alfano, Claudia, Bonzano, Marco, Briganti, Federica, Crescenzi, Giuseppe, Falchi, Anna G., Guarnone, Roberta, Guglielmana, Barbara, Maggi, Elena, Martino, Ilaria, Pettenazza, Pietro, Pioli di Marco, Serena, Quaglia, Federica, Sabena, Anna, Salinaro, Francesco, Speciale, Francesco, Zunino, Ilaria, De Lorenzo, Marzia, Secco, Gianmarco, Dimitry, Lorenzo, Cappa, Giovanni, Maisak, Igor, Chiodi, Benedetta, Sciarrini, Massimiliano, Barcella, Bruno, Resta, Flavia, Moroni, Luca, Vezzoni, Giulia, Scattaglia, Lorenzo, Boscolo, Elisa, Zattera, Caterina, Fidel, Tassi M., Vincenzo, Capozza, Vignaroli, Damiano, Bazzini, Marco, Iotti, Giorgio, Mojoli, Francesco, Belliato, Mirko, Perotti, Luciano, Mongodi, Silvia, Tavazzi, Guido, Marseglia, Gianluigi, Licari, Amelia, Brambilla, Ilaria, Daniela, Barbarini, Antonella, Bruno, Patrizia, Cambieri, Giulia, Campanini, Giuditta, Comolli, Marta, Corbella, Rossana, Daturi, Milena, Furione, Bianca, Mariani, Roberta, Maserati, Enza, Monzillo, Stefania, Paolucci, Maurizio, Parea, Elena, Percivalle, Antonio, Piralla, Francesca, Rovida, Antonella, Sarasini, Maurizio, Zavattoni, Guy, Adzasehoun, Laura, Bellotti, Ermanna, Cabano, Giuliana, Casali, Luca, Dossena, Gabriella, Frisco, Gabriella, Garbagnoli, Alessia, Girello, Viviana, Landini, Claudia, Lucchelli, Valentina, Maliardi, Simona, Pezzaia, Marta, Premoli, Alice, Bonetti, Giacomo, Caneva, Irene, Cassaniti, Alfonso, Corcione, Di Martino, Raffella, Di Napoli, Annapia, Alessandro, Ferrari, Guglielmo, Ferrari, Loretta, Fiorina, Federica, Giardina, Alessandra, Mercato, Federica, Novazzi, Giacomo, Ratano, Beatrice, Rossi, Maria, Sciabica I., Monica, Tallarita, Edoardo, Vecchio N., Cerino, Antonella, Varchetta, Stefania, Oliviero, Barbara, Mantovani, Stefania, Mele, Dalila, Calvi, Monica, Tizzonis, Michela, Nicora, Carlo, Triarico, Antonio, Petronella, Vincenzo, Marena, Carlo, Muzzi, Alba, Lago, Paolo, Comandatore, Francesco, Bissignandi, Gherard, Gaiarsa, Stefano, Rettani, Marco, and Band, Claudio

Subjects
Male, medicine.medical_specialty, ARDS, medicine.medical_treatment, infectious disease, Disease, 030230 surgery, clinical research/practice, Asymptomatic, Tacrolimus, Kidney Failure, 03 medical and health sciences, Betacoronavirus, 0302 clinical medicine, Glomerulonephritis, medicine, Extracorporeal membrane oxygenation, Immunology and Allergy, immunosuppressant – calcineurin inhibitor: tacrolimus, infection and infectious agents – viral, COVID-19, Ceftriaxone, Coronavirus Infections, Cytokines, Glomerulonephritis, IGA, Humans, Immunosuppression Therapy, Kidney Failure, Chronic, Middle Aged, Mycophenolic Acid, Pandemics, Pneumonia, Viral, SARS-CoV-2, Treatment Outcome, Kidney Transplantation, Pharmacology (medical), Viral, Chronic, Intensive care medicine, Kidney transplantation, IGA, Mechanical ventilation, Transplantation, business.industry, Immunosuppression, Pneumonia, medicine.disease, medicine.symptom, Cytokine storm, business
Abstract

The clinical manifestation of COVID-19 can vary from an asymptomatic course to ARDS requiring invasive mechanical ventilation and extracorporeal membrane oxygenation. A kidney transplanted patient infected with SARS CoV-2 infection showed a mild disease despite immune suppression. It is possible that Immunosuppression can "be protective" as the cytokine storm is an important factor in the disease story. Despite the good outcome reported in the present case report, is remains of vital importance the solid organ transplant patients use precautions in order to avoid the infection.

Published
2020

47. Hepatitis C

Author

Mondelli, Mario U., primary, Varchetta, Stefania, additional, and Negro, Francesco, additional

Published
2013
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48. Impact of COVID-19 on the care of patients with liver disease: EASL-ESCMID position paper after 6 months of the pandemic

Author

Universidad de Sevilla. Departamento de Medicina, National Institute of Health Research (NIHR) Birmingham Biomedical Research Centre (BRC), Boettler, Tobias, Marjot, Thomas, Newsome, Philip N., Mondelli, Mario U., Maticic, Mojca, Cordero Matia, María Elisa, Ryberg, Thomas, Universidad de Sevilla. Departamento de Medicina, National Institute of Health Research (NIHR) Birmingham Biomedical Research Centre (BRC), Boettler, Tobias, Marjot, Thomas, Newsome, Philip N., Mondelli, Mario U., Maticic, Mojca, Cordero Matia, María Elisa, and Ryberg, Thomas

Abstract

During the early stages of the coronavirus disease 2019 (COVID-19) pandemic, EASL and ESCMID published a position paper to provide guidance for physicians involved in the care of patients with chronic liver disease. While some healthcare systems are returning to a more normal routine, many countries and healthcare systems have been, or still are, overwhelmed by the pandemic, which is significantly impacting on the care of these patients. In addition, many studies have been published focusing on how COVID-19 may affect the liver and how pre-existing liver diseases might influence the clinical course of COVID-19. While many aspects remain poorly understood, it has become increasingly evident that pre-existing liver diseases and liver injury during the disease course must be kept in mind when caring for patients with COVID-19. This review should serve as an update on the previous position paper, summarising the evidence for liver disease involvement during COVID-19 and providing recommendations on how to return to routine care wherever possible.

Published
2020

49. Care of patients with liver disease during the COVID-19 pandemic: EASL-ESCMID position paper

Author

Universidad de Sevilla. Departamento de Medicina, Boettler, Tobias, Newsome, Philip N., Mondelli, Mario U., Maticic, Mojca, Cordero Matia, María Elisa, Cornberg, Markus, Ryberg, Thomas, Universidad de Sevilla. Departamento de Medicina, Boettler, Tobias, Newsome, Philip N., Mondelli, Mario U., Maticic, Mojca, Cordero Matia, María Elisa, Cornberg, Markus, and Ryberg, Thomas

Abstract

The coronavirus disease 2019 (COVID-19) pandemic poses an enormous challenge to healthcare systems in affected communities. Older patients and those with pre-existing medical conditions have been identified as populations at risk of a severe disease course. It remains unclear at this point to what extent chronic liver diseases should be considered as risk factors, due to a shortage of appropriate studies. However, patients with advanced liver disease and those after liver transplantation represent vulnerable patient cohorts with an increased risk of infection and/or a severe course of COVID-19. In addition, the current pandemic requires unusual allocation of healthcare resources which may negatively impact the care of patients with chronic liver disease that continue to require medical attention. Thus, the challenge hepatologists are facing is to promote telemedicine in the outpatient setting, prioritise outpatient contacts, avoid nosocomial dissemination of the virus to patients and healthcare providers, and at the same time maintain standard care for patients who require immediate medical attention.

Published
2020

50. Impact of COVID-19 on the care of patients with liver disease: EASL-ESCMID position paper after 6 months of the pandemic

Author

National Institutes of Health (US), National Health Service (UK), Boettler, Tobias [0000-0002-1195-055X], Maticic, Mojca [0000-0003-4261-0424], Cordero, Elisa [0000-0001-7766-7266], Moreau, Richard [0000-0003-0862-403X], Boettler, Tobias, Marjot, Thomas, Newsome, Philip N., Mondelli, Mario U., Maticic, Mojca, Cordero-Matía, Elisa, Jalan, Rajiv, Moreau, Richard, Cornberg, Markus, Berg, Thomas, National Institutes of Health (US), National Health Service (UK), Boettler, Tobias [0000-0002-1195-055X], Maticic, Mojca [0000-0003-4261-0424], Cordero, Elisa [0000-0001-7766-7266], Moreau, Richard [0000-0003-0862-403X], Boettler, Tobias, Marjot, Thomas, Newsome, Philip N., Mondelli, Mario U., Maticic, Mojca, Cordero-Matía, Elisa, Jalan, Rajiv, Moreau, Richard, Cornberg, Markus, and Berg, Thomas

Abstract

During the early stages of the COVID-19 pandemic, EASL and ESCMID published a position paper to provide guidance for physicians involved in the care of patients with chronic liver disease. In the meantime, many countries and healthcare systems have been, or are still overwhelmed by the pandemic, significantly impacting on the care of this group of patients, whilst others have started to return towards their usual routine. In addition, many studies have been published focusing on how COVID-19 may affect the liver and how pre-existing liver diseases might influence the clinical course of COVID-19. While many aspects remain poorly understood, it has become increasingly evident that pre-existing liver diseases and liver injury during the course of the disease have to be kept in mind when caring for patients with COVID-19. Thus, this review should serve as an update on the previous position paper summarizing the evidence for liver disease involvement during COVID-19 and also provid

Published
2020

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