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Herein, we reported an effective one‐pot protocol to synthesize quinazolinone fused N‐heterocyclic scaffold, structurally similar to the natural product Luotonin and Rutaecarpine by Pd(OAc)2/Ag(OAc)‐promoted intramolecular dehydrogenative cross‐coupling (DCC). The structure of all the compounds has been confirmed unambiguously by NMR, mass, and XRD. The electronic effect of the substituents attached to the backbone of the starting material was thoroughly investigated. The outcome of the reaction is highly dependent on the substrate structure and pH of the medium. Based on the experimental observation, a probable mechanism has been proposed. To see the anti‐cancer properties, we have studied concentration‐dependent cell viability assay of one compound on SiHa cell, a human cervical cancer cell line. The observed IC50 value was 23 μM. [ABSTRACT FROM AUTHOR]

Hydrolytic behavior of 5‐acetyl‐6‐methyl‐4‐phenyl‐3,4‐dihydropyrimidin‐2(1H)‐one under alkaline condition has been explored. Mechanistic details are established by LCMS and HPLC. Evidence suggested that the deacetylative benzylidenation proceeds through the retro‐Biginelli reaction. The scope of the retro‐Biginelli reaction has been explored by the synthesis of substituted DHPs. [ABSTRACT FROM AUTHOR]

Abstract Developing multicomponent reactions in a cascade manner is a long-standing interest to chemists to access valuable organic materials more economically. Herein, we described a simple, economically viable method for synthesizing 11H-benzo[b]fluoren-11-one, a dual-state organic fluorophore, starting from ortho phthalaldehyde (OPA) in DMSO solvent. Simple and rapid product isolation, high atom economy, short reaction time, and scalability are the attractive features of the method. During the optimization of the reaction condition, we observed that DMSO, DMF, and acetone served one carbon to form the said compound besides their role as solvents. A plausible mechanism has been proposed based on the evidence obtained from LCMS analysis of the incomplete reaction mixture. [ABSTRACT FROM AUTHOR]

The total syntheses of stagonolide B and its 4-epimer were carried out to probe into how the relative stereochemistry of allylic hydroxy groups and their protecting groups influence the efficiency of the ring closing metathesis.