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265 results on '"Monarca, Silvano"'

1. Buccal micronucleus cytome assay in primary school children: A descriptive analysis of the MAPEC_LIFE multicenter cohort study

Author

Fatigoni, Cristina, Monarca, Silvano, Covolo, Loredana, Feretti, Donatella, Festa, Andrea, Viola, Gaia Claudia Viviana, Zani, Claudia, Zerbini, Ilaria, Gilli, Giorgio, Carraro, Elisabetta, Schilirò, Tiziana, Pignata, Cristina, Gea, Marta, Romanazzi, Valeria, Donzelli, Gabriele, Palomba, Giacomo, Bagordo, Francesco, De Giorgi, Mattia, Guido, Marcello, Idolo, Adele, Panico, Alessandra, Serio, Francesca, Verri, Tiziano, Furia, Camilla, Colombi, Paolo, Codenotti, Roberta, Zagni, Licia, Villarini, Milena, Levorato, Sara, Salvatori, Tania, Ceretti, Elisabetta, Bonetta, Sara, Carducci, Annalaura, Grassi, Tiziana, Vannini, Samuele, Donato, Francesco, Bonetta, Silvia, Verani, Marco, de Donno, Antonella, Bonizzoni, Silvia, Bonetti, Alberto, Moretti, Massimo, and Gelatti, Umberto

Published
2018
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6. Micronuclei and chromosome aberrations in subjects occupationally exposed to antineoplastic drugs: a multicentric approach

Author

Moretti, Massimo, Grollino, Maria Giuseppa, Pavanello, Sofia, Bonfiglioli, Roberta, Villarini, Milena, Appolloni, Massimo, Carrieri, Mariella, Sabatini, Laura, Dominici, Luca, Stronati, Laura, Mastrangelo, Giuseppe, Barbieri, Anna, Fatigoni, Cristina, Bartolucci, Giovanni Battista, Ceretti, Elisabetta, Mussi, Francesca, and Monarca, Silvano

Published
2015
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19. A study protocol for the evaluation of occupational mutagenic/carcinogenic risks in subjects exposed to antineoplastic drugs: a multicentric project

Author

Gelatti Umberto, Sabatini Laura, Dominici Luca, Appolloni Massimo, Buschini Annamaria, Carrieri Mariella, Ceretti Elisabetta, Barbieri Anna, Villarini Milena, Grollino Maria G, Mussi Francesca, Pavanello Sofia, Feretti Donatella, Bonfiglioli Roberta, Moretti Massimo, Bartolucci Giovanni B, Poli Paola, Stronati Laura, Mastrangelo Giuseppe, and Monarca Silvano

Subjects
Public aspects of medicine, RA1-1270
Abstract

Abstract Background Some industrial hygiene studies have assessed occupational exposure to antineoplastic drugs; other epidemiological investigations have detected various toxicological effects in exposure groups labeled with the job title. In no research has the same population been studied both environmentally and epidemiologically. The protocol of the epidemiological study presented here uses an integrated environmental and biological monitoring approach. The aim is to assess in hospital nurses preparing and/or administering therapy to cancer patients the current level of occupational exposure to antineoplastic drugs, DNA and chromosome damage as cancer predictive effects, and the association between the two. Methods/Design About 80 healthy non-smoking female nurses, who job it is to prepare or handle antineoplastic drugs, and a reference group of about 80 healthy non-smoking female nurses not occupationally exposed to chemicals will be examined simultaneously in a cross-sectional study. All the workers will be recruited from five hospitals in northern and central Italy after their informed consent has been obtained. Evaluation of surface contamination and dermal exposure to antineoplastic drugs will be assessed by determining cyclophosphamide on selected surfaces (wipes) and on the exposed nurses' clothes (pads). The concentration of unmetabolized cyclophosphamide as a biomarker of internal dose will be measured in end-shift urine samples from exposed nurses. Biomarkers of effect and susceptibility will be assessed in exposed and unexposed nurses: urinary concentration of 8-hydroxy-2-deoxyguanosine; DNA damage detected using the single-cell microgel electrophoresis (comet) assay in peripheral white blood cells; micronuclei and chromosome aberrations in peripheral blood lymphocytes. Genetic polymorphisms for enzymes involved in metabolic detoxification (i.e. glutathione S-transferases) will also be analysed. Using standardized questionnaires, occupational exposure will be determined in exposed nurses only, whereas potential confounders (medicine consumption, lifestyle habits, diet and other non-occupational exposures) will be assessed in both groups of hospital workers. Statistical analysis will be performed to ascertain the association between occupational exposure to antineoplastic drugs and biomarkers of DNA and chromosome damage, after taking into account the effects of individual genetic susceptibility, and the presence of confounding exposures. Discussion The findings of the study will be useful in updating prevention procedures for handling antineoplastic drugs.

Published
2011
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22. Italian multicenter study on infection hazards during dental practice: Control of environmental microbial contamination in public dental surgeries

Author

Monarca Silvano, Fabiani Leila, Bergomi Margherita, Pasquarella Cesira, Napoli Christian, Montagna Maria, Liguori Giorgio, Castiglia Paolo, and Petti Stefano

Subjects
Public aspects of medicine, RA1-1270
Abstract

Abstract Background The present study assessed microbial contamination in Italian dental surgeries. Methods An evaluation of water, air and surface microbial contamination in 102 dental units was carried out in eight Italian cities. Results The findings showed water microbial contamination in all the dental surgeries; the proportion of water samples with microbial levels above those recommended decreased during working. With regard to Legionella spp., the proportion of positive samples was 33.3%. During work activity, the index of microbial air contamination (IMA) increased. The level of microbial accumulation on examined surfaces did not change over time. Conclusion These findings confirm that some Italian dental surgeries show high biocontamination, as in other European Countries, which highlights the risk of occupational exposure and the need to apply effective measures to reduce microbial loads.

Published
2008
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23. Lifestyles and socio-cultural factors among children aged 6-8 years from five Italian towns: The MAPEC-LIFE study cohort

Author

Bagordo, Francesco, De Donno, Antonella, Grassi, Tiziana, Guido, Marcello, Devoti, Gabriele, Ceretti, Elisabetta, Zani, Claudia, Feretti, Donatella, Villarini, Milena, Moretti, Massimo, Salvatori, Tania, Carducci, Annalaura, Verani, Marco, Casini, Beatrice, Bonetta, Sara, Carraro, Elisabetta, Schilirò, Tiziana, Bonizzoni, Silvia, Bonetti, Alberto, Gelatti, Umberto, Serio, Francesca, De Giorgi, Mattia, Idolo, Adele, Verri, Tiziano, Covolo, Loredana, Donato, Francesco, Festa, Andrea, Limina, Rosa Maria, Zerbini, Ilaria, Fatigoni, Cristina, Levorato, Sara, Monarca, Silvano, Vannini, Samuele, Donzelli, Gabriele, Bruni, Beatrice, Palomba, Giacomo, Bonetta, Silvia, Gea, Marta, Gilli, Giorgio, Pignata, Cristina, Romanazzi, Valeria, Furia, Camilla, Codenotti, Roberta, Colombi, Paolo, Crottini, Stefano, Gaffurini, Laura, Zagni, Licia, Bagordo, Francesco, De Donno, Antonella, Grassi, Tiziana, Guido, Marcello, Devoti, Gabriele, Ceretti, Elisabetta, Zani, Claudia, Feretti, Donatella, Villarini, Milena, Moretti, Massimo, Salvatori, Tania, Carducci, Annalaura, Verani, Marco, Casini, Beatrice, Bonetta, Sara, Carraro, Elisabetta, Schilirò, Tiziana, Bonizzoni, Silvia, Bonetti, Alberto, Gelatti, Umberto, Serio, Francesca, De Giorgi, Mattia, Idolo, Adele, Verri, Tiziano, Covolo, Loredana, Donato, Francesco, Festa, Andrea, Limina, Rosa Maria, Zerbini, Ilaria, Fatigoni, Cristina, Levorato, Sara, Monarca, Silvano, Vannini, Samuele, Donzelli, Gabriele, Bruni, Beatrice, Palomba, Giacomo, Bonetta, Silvia, Gea, Marta, Gilli, Giorgio, Pignata, Cristina, Romanazzi, Valeria, Furia, Camilla, Codenotti, Roberta, Colombi, Paolo, Crottini, Stefano, Gaffurini, Licia, Zagni, Licia, Donzelli, Gabriela, Gaffurini, Laura, and Zagni, Licia.

Subjects
Male, Parents, Passive smoking, Health Status, Health Behavior, 010501 environmental sciences, medicine.disease_cause, 01 natural sciences, Air pollution, Children, Exposure, Lifestyles, MAPEC-LIFE Study, Questionnaire, Public Health, Environmental and Occupational Health, Cohort Studies, 0302 clinical medicine, Surveys and Questionnaires, Epidemiology, Medicine, 030212 general & internal medicine, Child, MAPEC_LIFE Study, Family Characteristics, Children, Lifestyles, Exposure, Air pollution, Questionnaire, MAPEC_LIFE Study, lcsh:Public aspects of medicine, Italy, Cohort, Female, Seasons, Public Health, Research Article, medicine.medical_specialty, 03 medical and health sciences, Environmental health, Humans, Cities, Life Style, 0105 earth and related environmental sciences, business.industry, Public health, Environmental and Occupational Health, lcsh:RA1-1270, Anthropometry, medicine.disease, Lifestyle, Obesity, Socioeconomic Factors, Tobacco Smoke Pollution, Residence, Biostatistics, business
Abstract

Background Lifestyles profoundly determine the quality of an individual’s health and life since his childhood. Many diseases in adulthood are avoidable if health-risk behaviors are identified and improved at an early stage of life. The aim of the present research was to characterize a cohort of children aged 6–8 years selected in order to perform an epidemiological molecular study (the MAPEC_LIFE study), investigate lifestyles of the children that could have effect on their health status, and assess possible association between lifestyles and socio-cultural factors. Methods A questionnaire composed of 148 questions was administered in two different seasons to parents of children attending 18 primary schools in five Italian cities (Torino, Brescia, Pisa, Perugia and Lecce) to obtain information regarding the criteria for exclusion from the study, demographic, anthropometric and health information on the children, as well as some aspects on their lifestyles and parental characteristics. The results were analyzed in order to assess the frequency of specific conditions among the different seasons and cities and the association between lifestyles and socio-economic factors. Results The final cohort was composed of 1,164 children (50.9 boys, 95.4% born in Italy). Frequency of some factors appeared different in terms of the survey season (physical activity in the open air, the ways of cooking certain foods) and among the various cities (parents’ level of education and rate of employment, sport, traffic near the home, type of heating, exposure to passive smoking, ways of cooking certain foods). Exposure to passive smoking and cooking fumes, obesity, residence in areas with heavy traffic, frequency of outdoor play and consumption of barbecued and fried foods were higher among children living in families with low educational and/or occupational level while children doing sports and consuming toasted bread were more frequent in families with high socio-economic level. Conclusions The socio-economic level seems to affect the lifestyles of children enrolled in the study including those that could cause health effects. Many factors are linked to the geographical area and may depend on environmental, cultural and social aspects of the city of residence.

Published
2017

24. Educazione sanitaria, quale ruolo per il farmacista? Risultati di uno studio trasversale in Umbria

Author

Gianfredi, Vincenza, Monarca, Silvano, Moretti, Massimo, Villarini, Milena, Gianfredi, Vincenza, Monarca, Silvano, Moretti, Massimo, and Villarini, Milena

Subjects
Educazione sanitaria, farmacia dei servizi, farmacista di comunità, promozione della salute, questionario, studio cross-sectional, questionario, studio cross-sectional, promozione della salute, Educazione sanitaria, farmacista di comunità, farmacia dei servizi
Abstract

Introduzione. Attualmente la figura del farmacista di comunità sta subendo profonde trasformazioni. Il farmacista, come operatore sanitario del Servizio Sanitario Nazionale, sta ampliando le sue competenze nell’ambito della sanità pubblica, attraverso interventi di prevenzione delle malattie e di promozione della salute. La ricerca ha avuto come obiettivo quello di valutare le conoscenze, gli atteggiamenti e i comportamenti di un campione selezionato di farmacisti titolari di farmacie private e pubbliche della provincia di Perugia e Terni, nei confronti degli interventi di educazione sanitaria e di promozione della salute effettuati. Metodi. Studio cross-sectional condotto mediante l’utilizzo di due strumenti di rilevazione: un questionario anonimo autocompilato contenente 29 domande; una scheda di valutazione ambientale composta da 21 item, compilata da studenti di Scienze farmaceutiche. Risultati. Hanno aderito al progetto il 70% dei farmacisti umbri, che nel 68,9% dei casi ritiene gli interventi di educazione sanitaria molto rilevanti; il 57% è favorevole alla gratuità di tali interventi, con un monte ore settimanale, dedicato a tale attività, di 14,5. Conclusioni. L’indagine mostra una buona sensibilità dei farmacisti nei confronti delle tematiche di educazione sanitaria. Infatti, il farmacista può e deve avere un ruolo essenziale nel coinvolgere responsabilmente tutti i cittadini nella promozione di nuovi comportamenti nei confronti della salute.

Published
2017

29. Buccal micronucleus cytome assay in primary school children: A descriptive analysis of the MAPEC_LIFE multicenter cohort study

Author

Villarini, Milena, primary, Levorato, Sara, additional, Salvatori, Tania, additional, Ceretti, Elisabetta, additional, Bonetta, Sara, additional, Carducci, Annalaura, additional, Grassi, Tiziana, additional, Vannini, Samuele, additional, Donato, Francesco, additional, Bonetta, Silvia, additional, Verani, Marco, additional, de Donno, Antonella, additional, Bonizzoni, Silvia, additional, Bonetti, Alberto, additional, Moretti, Massimo, additional, Gelatti, Umberto, additional, Fatigoni, Cristina, additional, Monarca, Silvano, additional, Covolo, Loredana, additional, Feretti, Donatella, additional, Festa, Andrea, additional, Viola, Gaia Claudia Viviana, additional, Zani, Claudia, additional, Zerbini, Ilaria, additional, Gilli, Giorgio, additional, Carraro, Elisabetta, additional, Schilirò, Tiziana, additional, Pignata, Cristina, additional, Gea, Marta, additional, Romanazzi, Valeria, additional, Donzelli, Gabriele, additional, Palomba, Giacomo, additional, Bagordo, Francesco, additional, De Giorgi, Mattia, additional, Guido, Marcello, additional, Idolo, Adele, additional, Panico, Alessandra, additional, Serio, Francesca, additional, Verri, Tiziano, additional, Furia, Camilla, additional, Colombi, Paolo, additional, Codenotti, Roberta, additional, and Zagni, Licia, additional

Published
2018
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50. Genotossicità di clorito e clorato

Author

Feretti, D, Zerbini, I, Ceretti, E, Zani, C, Donato, F, Fatigoni, Cristina, Villarini, Milena, Moretti, Massimo, and Monarca, Silvano

Published
2009

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