13 results on '"Monaldini C."'
Search Results
2. Serum IgG against Simian Virus 40 antigens are hampered by high levels of sHLA-G in patients affected by inflammatory neurological diseases, as multiple sclerosis
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Rizzo, Roberta, Pietrobon, Silvia, Mazzoni, Elisa, Bortolotti, D., Martini, Fernanda, Castellazzi, Massimiliano, Casetta, Ilaria, Fainardi, Enrico, Luca, Dario, Granieri, Enrico, Tognon, Mauro, Granieri, E., Castellazzi, M., Casetta, I., Tola, M. R., Fainardi, E., Dallocchio, F., Bellini, T., Rizzo, R., Rotola, A., Di Luca, D., Seraceni, S., Contini, C., Sabbioni, S., Negrini, M., Tognon, M., Antonelli, T., Groppo, E., Gentile, M., Baldi, E., Caniatti, M. L., Ceruti, S., Manfrinato, M. R., Trentini, A., Miotto, E., Ferracin, M., Mazzoni, E., Pietrobon, S., Masini, I., Rotondo, J. C., Martini, F., Baruzzi, A., Roberto D'Alessandro, R., Michelucci, R., Salvi, F., Stecchi, S., Scandellari, C., Terzano, G., Granella, F., Nichelli, Paolo Frigio, Sola, P., Ferraro, Diana, Vitetta, F., Simone, ANNA MARIA, Bedin, Roberta, Marcello, N., Motti, L., Montepietra, S., Guidetti, D., Immovilli, P., Montanari, E., Pesci, I., Guareschi, A., Greco, G., Santangelo, M., Mauro, A. M., Malagù, S., Rasi, F., Spadoni, M., Galeotti, M., Fiorani, L., Neri, W., Ravasio, A., Pasquinelli, M., Gutman, S., and Monaldini, C.
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0301 basic medicine ,Adult ,Male ,viruses ,HLA-G ,Socio-culturale ,Multiple sclerosis ,SV40 ,Medicine (all) ,Biochemistry, Genetics and Molecular Biology (all) ,Disease ,Human leukocyte antigen ,Simian virus 40 ,Antibodies, Viral ,General Biochemistry, Genetics and Molecular Biology ,Immunoglobulin G ,Virus ,03 medical and health sciences ,0302 clinical medicine ,Antigen ,Aged ,Antigens, Viral ,Female ,HLA-G Antigens ,Humans ,Inflammation ,Middle Aged ,Multiple Sclerosis ,Solubility ,medicine ,Medicine(all) ,biology ,business.industry ,Biochemistry, Genetics and Molecular Biology(all) ,Research ,General Medicine ,medicine.disease ,030104 developmental biology ,Immunology ,biology.protein ,business ,030217 neurology & neurosurgery - Abstract
Background Many investigators detected the simian polyomavirus SV40 footprints in human brain tumors and neurologic diseases and recently it has been indicated that SV40 seems to be associated with multiple sclerosis (MS) disease. Interestingly, SV40 interacts with human leukocyte antigen (HLA) class I molecules for cell entry. HLA class I antigens, in particular non-classical HLA-G molecules, characterized by an immune-regulatory function, are involved in MS disease, and the levels of these molecules are modified according with the disease status. Objective We investigated in serum samples, from Italian patients affected by MS, other inflammatory diseases (OIND), non-inflammatory neurological diseases (NIND) and healthy subjects (HS), SV40-antibody and soluble sHLA-G and the association between SV40-prevalence and sHLA-G levels. Methods ELISA tests were used for SV40-antibodies detection and sHLA-G quantitation in serum samples. Results The presence of SV40 antibodies was observed in 6 % of patients affected by MS (N = 4/63), 10 % of OIND (N = 8/77) and 15 % of NIND (N = 9/59), which is suggestive of a lower prevalence in respect to HS (22 %, N = 18/83). MS patients are characterized by higher sHLA-G serum levels (13.9 ± 0.9 ng/ml; mean ± St. Error) in comparison with OIND (6.7 ± 0.8 ng/ml), NIND (2.9 ± 0.4 ng/ml) and HS (2.6 ± 0.7 ng/ml) subjects. Interestingly, we observed an inverse correlation between SV40 antibody prevalence and sHLA-G serum levels in MS patients. Conclusion The data obtained showed a low prevalence of SV40 antibodies in MS patients. These results seems to be due to a generalized status of inability to counteract SV40 infection via antibody production. In particular, we hypothesize that SV40 immune-inhibitory direct effect and the presence of high levels of the immune-inhibitory HLA-G molecules could co-operate in impairing B lymphocyte activation towards SV40 specific peptides.
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- 2016
3. Investigation of a clock gene polymorphism in Cluster Headache (CH)
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MONTAGNA, PASQUALE, MOCHI, MIRELLA, PIERANGELI, GIULIA, ZANIGNI, STEFANO, CORTELLI, PIETRO, CEVOLI, SABINA, Monaldini C., Bonavina G., Torelli P., Manzoni G. C., Cevoli S., Mochi M., Pierangeli G., Zanigni S., Monaldini C., Bonavina G., Torelli P., Manzoni G.C., Cortelli P., and Montagna P.
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- 2005
4. Familial late-onset migraine with aura
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Bonavina G., Monaldini C., PIERANGELI, GIULIA, CEVOLI, SABINA, ZANIGNI, STEFANO, SANCISI, ELISA, D'ALESSANDRO, ROBERTO, CORTELLI, PIETRO, Bonavina G., Pierangeli G., Cevoli S., Monaldini C., Zanigni S., Sancisi E., D'Alessandro R., and Cortelli P.
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GENETICA ,EMICRANIA CON AURA - Published
- 2004
5. Two year follow-up results of transcatheter closure of an interatrial cardiac defect in two migraine with aura (MWA) patients
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ZANIGNI, STEFANO, PIERANGELI, GIULIA, CEVOLI, SABINA, SANCISI, ELISA, MONTAGNA, PASQUALE, CORTELLI, PIETRO, Monaldini C., Donti A., Zanigni S., Pierangeli G., Cevoli S., Monaldini C., Sancisi E., Donti A., Montagna P., and Cortelli P.
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FORAME OVALE PERVIO ,EMICRANIA CON AURA - Published
- 2004
6. Headache in Behçet’s disease: case reports and literature review
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Volpinari, S., primary, Monaldini, C., additional, Capone, J.G., additional, Lo Monaco, A., additional, La Corte, R., additional, Trotta, F., additional, and Govoni, M., additional
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- 2011
- Full Text
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7. Multiple sclerosis in the Republic of San Marino: a prevalence and incidence study
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Granieri, E., primary, Monaldini, C., additional, De Gennaro, R., additional, Guttmann, S., additional, Volpini, M., additional, Stumpo, M., additional, Fazio, P., additional, and Casetta, I., additional
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- 2008
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8. Headache in Behçet's disease: Case reports and literature review | La cefalea nella malattia di Behçet: Contributo casistico e revisione della letteratura
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Volpinari, S., Monaldini, C., Capone, J. G., Lo Monaco, A., La Corte, R., Trotta, F., and Marcello Govoni
9. The role of cardiac diseases in the comorbidity between migraine and stroke
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Elisa Sancisi, Sabina Cevoli, Giulia Pierangeli, Stefano Zanigni, Pietro Cortelli, Pasquale Montagna, C. Monaldini, M. A. Ribani, A. Donti, Pierangeli G., Cevoli S., Zanigni S., Sancisi E., Monaldini C., Donti A., Ribani MA., Montagna P., and Cortelli P.
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medicine.medical_specialty ,Neurology ,Heart Diseases ,Migraine Disorders ,Coronary Disease ,Comorbidity ,Dermatology ,Heart Septal Defects, Atrial ,Cohort Studies ,Internal medicine ,medicine ,Humans ,Stroke ,COMORBILITÀ ,Mitral Valve Prolapse ,Vascular disease ,business.industry ,General Medicine ,CARDIOVASCOLARE ,medicine.disease ,Migraine with aura ,EMICRANIA CON AURA ,Aortic Aneurysm ,Psychiatry and Mental health ,Migraine ,Cardiology ,Patent foramen ovale ,Neurology (clinical) ,medicine.symptom ,business ,Cohort study - Abstract
Several case-control and cohort studies have suggested an association between migraine and stroke. A significantly higher risk for stroke was found in women under the age of 45 years and for the subgroup with migraine with aura, the posterior circulation being significantly more frequently involved. The link between cardiac diseases and the comorbidity migraine-stroke has been evaluated considering both possible relationships: a higher prevalence of a vascular disease involving both heart and brain in migraineurs, or a cardiac disorder, more prevalent in migraineurs, with a possible aetiological role in migraine attacks.
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- 2004
10. EEG microstate complexity for aiding early diagnosis of Alzheimer's disease.
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Tait L, Tamagnini F, Stothart G, Barvas E, Monaldini C, Frusciante R, Volpini M, Guttmann S, Coulthard E, Brown JT, Kazanina N, and Goodfellow M
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- Aged, Aged, 80 and over, Alzheimer Disease physiopathology, Early Diagnosis, Female, Humans, Male, Sensitivity and Specificity, Alzheimer Disease diagnosis, Brain physiopathology, Brain Mapping methods, Electroencephalography methods
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The dynamics of the resting brain exhibit transitions between a small number of discrete networks, each remaining stable for tens to hundreds of milliseconds. These functional microstates are thought to be the building blocks of spontaneous consciousness. The electroencephalogram (EEG) is a useful tool for imaging microstates, and EEG microstate analysis can potentially give insight into altered brain dynamics underpinning cognitive impairment in disorders such as Alzheimer's disease (AD). Since EEG is non-invasive and relatively inexpensive, EEG microstates have the potential to be useful clinical tools for aiding early diagnosis of AD. In this study, EEG was collected from two independent cohorts of probable AD and cognitively healthy control participants, and a cohort of mild cognitive impairment (MCI) patients with four-year clinical follow-up. The microstate associated with the frontoparietal working-memory/attention network was altered in AD due to parietal inactivation. Using a novel measure of complexity, we found microstate transitioning was slower and less complex in AD. When combined with a spectral EEG measure, microstate complexity could classify AD with sensitivity and specificity > 80%, which was tested on an independent cohort, and could predict progression from MCI to AD in a small preliminary test cohort of 11 participants. EEG microstates therefore have potential to be a non-invasive functional biomarker of AD.
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- 2020
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11. Multiple sclerosis in the Republic of San Marino, Italian peninsula: an incidence and prevalence study from a high-risk area.
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Caniglia-Tenaglia M, Guttmann S, Monaldini C, Manzaroli D, Volpini M, Stumpo M, Groppo E, Casetta I, Govoni V, Fonderico M, Pugliatti M, and Granieri E
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- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Incidence, Infant, Infant, Newborn, Male, Middle Aged, Prevalence, San Marino epidemiology, Sex Factors, Young Adult, Multiple Sclerosis epidemiology
- Abstract
Epidemiological studies on multiple sclerosis (MS) carried out in Southern Europe in the last years have shown a significant increase in the disease frequency. Previous surveys conducted in the Republic of San Marino, Northern Italian peninsula, identified that the population is at high risk for MS, with a prevalence of 51.6 per 100,000 population in 1982 and of 166.7 in 2005 and with a mean annual incidence of 7.9 per 100,000 for the period 1990-2005. The present work is a community-based intensive prevalence and incidence survey, by a complete enumeration approach, to update the prevalence and incidence of MS in the Republic of San Marino. The mean annual incidence for the period 2005-14 was 7.7 (95% CI 4.9-11.4) per 100,000, 3.3 (95% CI 1.1-7.6) for men and 11.9 (95% CI 7.2-18.6) for women. On 31 December 2014, 67 patients (19 men and 48 women), suffering from definite or probable MS and living in the Republic of San Marino, yielded a crude prevalence of 204.3 (95% CI 158.4-259.5) per 100,000, 117.8 (95% CI 70.9-183.7) for men and 288.2 (95% CI 212.4-383.3) for women. Our study has confirmed San Marino is an area at high risk for MS, in line with epidemiological data from continental Italy. The marked increase in MS prevalence over time in this population can be ascribable to increased survival and improved ascertainment, in the presence of a substantially stable, yet high, incidence rate.
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- 2018
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12. [Headache in Behçet's disease: case-control study and literature review].
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Volpinari S, Monaldini C, Capone JG, Lo Monaco A, La Corte R, Trotta F, and Govoni M
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- Adult, Aged, Behcet Syndrome diagnosis, Behcet Syndrome epidemiology, Case-Control Studies, Female, Headache diagnosis, Headache epidemiology, Humans, Italy epidemiology, Male, Middle Aged, Prevalence, Risk Factors, Surveys and Questionnaires, Behcet Syndrome complications, Headache etiology
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Objective: To evaluate the prevalence of headache and its different patterns in patients with Behçet's disease (BD) with and without neurological involvement and to investigate clinical correlations., Methods: Patients fulfilling the International Study Group criteria for Behçet disease (ISGc) were studied. Patients were invited to fill a "headache questionnaire", which consisted of two sections: the first one included demographic and anamnestic data, family history for both headache and BD, disease duration and clinical manifestations of BD; the second section included items about headache, investigated accordingly to International Headache Society diagnostic criteria (IHS, 2004). Clinical history and current comorbidities-medications were collected. Each patient underwent a neurological examination to assess neurological involvement (Neuro-BD) and, if necessary, instrumental investigations. One hundred-fifty healthy subjects matched for age and gender were used as control group for comparison., Results: Of the 55 patients diagnosed as BD (ISG criteria) 41 patients adhered and were enrolled into the study. Headache occurred in 29 of BD patients (70,7%) and in 13 of Neuro-BD patients (92,8%). Migraine without aura did prove the most frequent type of headache in BD patients (with and without neurological involvement) and there were no differences in the frequency of the different pattern of headache between BD patients and controls., Conclusions: Headache is a frequent manifestation in BD and primary headache like migraine emerged as the most frequent type of headache. A careful search for headache should be included in the diagnostic work-up of BD since this manifestation may be related to the underlying disease.
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- 2009
13. Multiple sclerosis in the Republic of San Marino: a prevalence and incidence study.
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Granieri E, Monaldini C, De Gennaro R, Guttmann S, Volpini M, Stumpo M, Fazio P, and Casetta I
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- Adolescent, Adult, Age Distribution, Aged, Female, Humans, Incidence, Male, Middle Aged, Prevalence, San Marino epidemiology, Sex Distribution, Multiple Sclerosis, Chronic Progressive epidemiology, Multiple Sclerosis, Relapsing-Remitting epidemiology
- Abstract
Studies on the distribution of multiple sclerosis (MS) carried out in Southern Europe in the last years have shown a significant increase in the frequency of the disease. A previous descriptive survey in the Republic of San Marino, northern Italian peninsula, published in 1984 established that this area is at high risk for MS. We updated the frequency estimates of the disease by adopting a complete enumeration approach. On 31 December 2005, 50 MS patients (36 women and 14 men) yielded a crude prevalence rate of 166.7 per 100, 000 (95% CI 123.7-220), 235.3 (95% CI 165-327.4) for women and 95.2 (95% CI 52-160) for men. The average incidence from 1990 to 2005 was 7.9 (95% CI 5.3-11.1) per 100,000, 11.7 (95% CI 7.6-17.3) for women and 3.9 (95% CI 1.7-7.7) for men. We did not detect any significant temporal trend over the study period. These results confirm that in San Marino the disease occurs more frequently than that suggested in the past and support the data on MS frequency in continental Italy. The marked increase in MS prevalence ratio is partly due to the increasing survival of patients and the accumulation of new incidence cases owing to the reduction in diagnostic latency for better quality of neurological diagnostic procedures. However, an increased incidence of the disease could be considered.
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- 2008
- Full Text
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