205 results on '"Monaghan, MJ"'
Search Results
2. Poster session Friday 13 December - PM: 13/12/2013, 14: 00–18: 00Location: Poster area
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Tayyareci, Y, Dworakowski, R, Kogoj, P, Reiken, J, Kenny, C, Maccarthy, P, Wendler, O, and Monaghan, MJ
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- 2013
3. Sonovue improves endocardial border detection and variability in assessing wall motion score and ejection fraction during stress echocardiography
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Brown, AS, Calachanis, M, Evdoridis, C, Hancock, J, Wild, S, Prasan, A, Nihoyannopoulos, P, and Monaghan, MJ
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- 2004
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4. Poster Session: Right ventricular systolic function
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Delithanasis, I, Celutkiene, J, Kenny, C, and Monaghan, MJ
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- 2012
5. Poster session Friday 7 December - PM: Effect of systemic illnesses on the heart
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Gianstefani, S, Catibog, N, Whittaker, A, Wathen, P, Kogoj, P, Reiken, J, and Monaghan, MJ
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- 2012
6. Club 35 Poster Session Wednesday 5 DecemberRight ventricular systolic function
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Kenny, C and Monaghan, MJ
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- 2012
7. P730Can 3D dyssynchrony after CRT implant identify patients that benefit from CRT optimization?
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Adhya, S, Harries, DG, Walker, NJ, Pearson, P, Reiken, J, Batteson, J, Kamdar, RH, Murgatroyd, FD, and Monaghan, MJ
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- 2011
8. P643Is transoesophageal echocardiography under conscious sedation safe in high risk patients considered for TAVI?
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Kenny, C, Adhya, S, Dworakowski, R, Brickham, B, Maccarthy, P, and Monaghan, MJ
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- 2011
9. P474An inter-institutional evaluation of new speckle tracking algorithms to assess left ventricular dyssynchrony with 3D echocardiography
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Adhya, S, Tsang, W, Kenny, C, Kapetanakis, S, Lang, RM, and Monaghan, MJ
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- 2011
10. P338Does contrast echocardiography still have a role for diagnosing left ventricular thrombus in patients following ST elevation myocardial infarction?
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Delithanasis, I, Celutkiene, J, Kenny, C, and Monaghan, MJ
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- 2011
11. Echocardiography 1997
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NIHOYANNOPOULOS, P and MONAGHAN, MJ
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- 1997
12. Beyond Bernoulli: Improving the Accuracy and Precision of Noninvasive Estimation of Peak Pressure Drops
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Donati, F, Myerson, S, Bissell, MM, Smith, NP, Neubauer, S, Monaghan, MJ, Nordsletten, DA, and Lamata, P
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Physics::Fluid Dynamics ,Quantitative Biology::Tissues and Organs - Abstract
Background: Transvalvular peak pressure drops are routinely assessed noninvasively by echocardiography using the Bernoulli principle. However, the Bernoulli principle relies on several approximations that may not be appropriate, including that the majority of the pressure drop is because of the spatial acceleration of the blood flow, and the ejection jet is a single streamline (single peak velocity value).\ud \ud \ud \ud Methods and Results: We assessed the accuracy of the Bernoulli principle to estimate the peak pressure drop at the aortic valve using 3-dimensional cardiovascular magnetic resonance flow data in 32 subjects. Reference pressure drops were computed from the flow field, accounting for the principles of physics (ie, the Navier–Stokes equations). Analysis of the pressure components confirmed that the spatial acceleration of the blood jet through the valve is most significant (accounting for 99% of the total drop in stenotic subjects). However, the Bernoulli formulation demonstrated a consistent overestimation of the transvalvular pressure (average of 54%, range 5%–136%) resulting from the use of a single peak velocity value, which neglects the velocity distribution across the aortic valve plane. This assumption was a source of uncontrolled variability.\ud \ud \ud \ud Conclusions: The application of the Bernoulli formulation results in a clinically significant overestimation of peak pressure drops because of approximation of blood flow as a single streamline. A corrected formulation that accounts for the cross-sectional profile of the blood flow is proposed and adapted to both cardiovascular magnetic resonance and echocardiographic data.
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- 2017
13. Beyond Bernoulli: improving accuracy and precision of non-invasive peak pressure drops
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Donati, F, Myerson, S, Bissell, M, Smith, NP, Neubauer, S, Monaghan, MJ, Nordsletten, DA, and Lamata, P
- Subjects
Physics::Fluid Dynamics ,Quantitative Biology::Tissues and Organs - Abstract
Background—Transvalvular peak pressure drops are routinely assessed non-invasively by echocardiography using the Bernoulli principle. However, the Bernoulli principle relies on a number of approximations, that may not be appropriate, including that the majority of the pressure drop is due to the spatial acceleration of the blood flow, and the ejection jet is a single streamline (single peak velocity value). Methods and Results—We assessed the accuracy of Bernoulli principle to estimate the peak pressure drop at the aortic valve using three-dimensional cardiovascular magnetic resonance flow data in 32 subjects. Reference pressure drops were computed from the flow field accounting for the principles of physics (i.e. the Navier-Stokes equations). Analysis of the pressure components confirmed that the spatial acceleration of the blood jet through the valve is most significant (accounting for 99% of the total drop in stenotic subjects). However, the Bernoulli formulation demonstrated a consistent overestimation of the transvalvular pressure (average of 54%, range 5-136%) resulting from the use of a single peak velocity value, which neglects the velocity distribution across the aortic valve plane. This assumption was a source of uncontrolled variability. Conclusions—The application of the Bernoulli formulation results in a clinically significant overestimation of peak pressure drops due to approximation of blood flow as a single streamline. A corrected formulation that accounts for the cross sectional profile of the blood flow is proposed and adapted to both CMR and echocardiographic data.
- Published
- 2016
14. Rapid Fire Abstract: Coronary artery disease: the crucial role of imaging369Left ventricular longitudinal strain is superior to blood biomarkers in prediction of poor exercise capacity in patients with a first-ever STEMI370Early identification of STEMI patients treated with pPCI at risk to develop heart failure during follow-up: speckle tracking echocardiographic study371The clinical and cost effectiveness of stress echocardiography in patients with new onset chest pain and high pre-test probability372PROSPECT CMR study: PROgnostic Stratification in Patients with ST-Elevation myoCardialinfaction over Transthoracic echocardiography by CMR373Exercise induced changes in global longitudinal strain in patients with chest pain and normal troponin-t may identify and rule out coronary artery disease.
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Przewlocka-Kosmala, M., primary, Trifunovic, D., primary, Papachristidis, A., primary, Pontone, G., primary, Karlsen, S., primary, Woznicka, AK., additional, Rojek, A., additional, Mysiak, A., additional, Kosmala, W., additional, Krljanac, G., additional, Savic, L., additional, Asanin, M., additional, Lasica, R., additional, Matovic, D., additional, Stepanovic, J., additional, Stankovic, G., additional, Mrdovic, I., additional, Casar Demarco, D., additional, Roper, D., additional, Tsironis, I., additional, Papitsas, M., additional, Byrne, J., additional, Alfakih, K., additional, Monaghan, MJ., additional, Andreini, D., additional, Ferro, G., additional, Guaricci, AI., additional, Guglielmo, M., additional, Mushtaq, S., additional, Baggiano, A., additional, Carita', P., additional, Verdecchia, M., additional, Pepi, M., additional, Dahlslett, T., additional, Grenne, B., additional, Sjoli, B., additional, Smiseth, OA., additional, Edvardsen, T., additional, and Brunvand, H., additional
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- 2016
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15. Poster Session 3The imaging examination and quality assessmentP626Value of mitral and tricuspid annular displacement to assess the interventricular systolic relationship in severe aortic valve stenosis : a Pilot studyP627Follow-up echocardiography in asymptomatic valve disease: assessing the potential economic impact of the European and American guidelines in a dedicated valve clinic, compared to standard care.P628The tricuspid valve: identification of optimal view for assessing for prolapseP629Right atrial volume by two-dimensional echocardiography in healthy subjectsP630Disturbance of inter and intra atrial conduction assessed by tissue doppler imaging in patients with medicaly controlled hypertension and prehypertension.P631Liver stiffness by shear wave elastography, new noninvasive and quantitative tool for acute variation estimation of central venous pressure in real-time?P632Weak atrial kick contribution is associated with a risk for heart failure decompensationP633Usefulness of wave intensity analysis in predicting the response to cardiac resynchronization therapyP634Early subclinical left ventricular systolic and diastolic dysfunction in gestational hypertension and preeclampsiaP635Clinical comparison of three different echocardiographic methods for left ventricular ejection fraction and LV end diastolic volume measurementP636Assessment of right ventricular-arterial coupling parameters by 3D echocardiography in patients with pulmonary hypertension receiving specific vasodilator therapyP637Prediction of right ventricular failure after left ventricular assist device implant: assessing usefulness of standard and strain echocardiographyP638Kinematic analysis of diastolic function using the novel freely available software Echo E-waves - feasibility and reproducibilityP639Evaluation of coronary flow velocity by Doppler echocardiography in the treatment of hypertension with the ARB: correlation to the histological cardiac fibrosisP640The clinical significance of limited apical ischaemia and the prognostic value of stress echocardiography - A contemporary study from a high volume centerP641Effects of intermediate stenosis of left anterior descending coronary artery on survival in patients with chronic total occlusion of right coronary arteryP642Left ventricular remodeling after a first myocardial infarction in patients with preserved ejection fraction at dischargeP643Left atrial size and acute coronary syndromes. Let is make simple.P644Influence of STEMI reperfusion strategy on systolic and diastolic functionP645Aortic valve resistance risk-stratifies low-gradient severe aortic stenosisP646Does permanent pacemaker implantation complicate the prognosis of patients after transcatheter aortic valve implantation?P647Influence of metabolic syndrome and diabetes on progression of calcific aortic valve stenosis - The COFRASA - GENERAC StudyP648Low referral for aortic valve replacement accounts for worse long-term outcome in low versus high gradient severe aortic stenosis with preserved ejection fractionP649The impact of right ventricular function from aortic valve replacement: A randomised study comparing minimally invasive aortic valve surgery and conventional open heart surgery
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Ota, T., primary, Senaratne, DNS, primary, Preston, NK., primary, Ferrara, F., primary, Djikic, D., primary, Villemain, O., primary, Takahashi, L., primary, Niki, K., primary, Patrascu, N., primary, Benyounes, N., primary, Popa, E., primary, Diego Bellavia, DB., primary, Sundqvist, M., primary, Wei-Ting, C., primary, Papachristidis, A., primary, Djordjevic-Dikic, A., primary, Volpi, C., primary, Reis, L., primary, Nieto Tolosa, J., primary, Nishikawa, H., primary, D'angelo, M., primary, Testuz, A., primary, Mo, YJ., primary, Hashemi, N., primary, Toyota, K., additional, Nagamine, K., additional, Koide, Y., additional, Nomura, T., additional, Kurata, J., additional, Murakami, Y., additional, Kozuka, Y., additional, Ohshiro, C., additional, Thomas, K., additional, Townsend, C., additional, Wheeler, S., additional, Jacobson, I., additional, Elkington, A., additional, Balkhausen, K., additional, Bull, S., additional, Ring, L., additional, Gargani, L., additional, Carannante, L., additional, Russo, V., additional, D'alto, M., additional, Marra, AM., additional, Cittadini, A., additional, D'andrea, A., additional, Vriz, O., additional, Bossone, E., additional, Mujovic, N., additional, Dejanovic, B., additional, Peric, V., additional, Marinkovic, M., additional, Jankovic, N., additional, Orbovic, B., additional, Simic, D., additional, Sitefane, F., additional, Pernot, M., additional, Malekzadeh-Milani, G., additional, Baranger, J., additional, Bonnet, D., additional, Boudjemline, Y., additional, Uejima, T., additional, Nishikawa, H., additional, Semba, H., additional, Sawada, H., additional, Yamashita, T., additional, Sugawara, M., additional, Kayanuma, H., additional, Inoue, K., additional, Yagawa, M., additional, Takamisawa, I., additional, Umemura, J., additional, Yoshikawa, T., additional, Tomoike, H., additional, Mihalcea, DJ., additional, Mihaila, S., additional, Lungeanu, L., additional, Trasca, LF., additional, Bruja, R., additional, Neagu, MS., additional, Albu, S., additional, Cirstoiu, M., additional, Vinereanu, D., additional, Van Der Vynckt, C., additional, Gout, O., additional, Cohen, A., additional, Enache, R., additional, Jurcut, R., additional, Coman, IM., additional, Badea, R., additional, Platon, P., additional, Calin, A., additional, Beladan, CC., additional, Rosca, M., additional, Ginghina, C., additional, Popescu, BA., additional, Sonia Dell'oglio, SD., additional, Attilio Iacovoni, AI., additional, Calogero Falletta, CF., additional, Giuseppe Romano, GR., additional, Sergio Sciacca, SS., additional, Lissa Sugeng, LS., additional, Joseph Maalouf, JM., additional, Michele Pilato, MP., additional, Michele Senni, MS., additional, Cesare Scardulla, CS., additional, Francesco Clemenza, FC., additional, Salman, K., additional, Tornvall, P., additional, Ugander, M., additional, Chen, ZC., additional, Wang, JJ., additional, Fisch, S., additional, Liao, RL., additional, Roper, D., additional, Casar Demarco, D., additional, Papitsas, M., additional, Tsironis, I., additional, Byrne, J., additional, Alfakih, K., additional, Monaghan, MJ., additional, Boskovic, N., additional, Rakocevic, I., additional, Giga, V., additional, Tesic, M., additional, Stepanovic, J., additional, Nedeljkovic, I., additional, Aleksandric, S., additional, Kostic, J., additional, Beleslin, B., additional, Altman, M., additional, Annabi, MS., additional, Abouchakra, L., additional, Cucchini, U., additional, Muraru, D., additional, Badano, LP., additional, Ernande, L., additional, Derumeaux, G., additional, Teixeira, R., additional, Fernandes, A., additional, Almeida, I., additional, Dinis, P., additional, Madeira, M., additional, Ribeiro, J., additional, Puga, L., additional, Nascimento, J., additional, Goncalves, L., additional, Cambronero Sanchez, FJ., additional, Pinar Bermudez, E., additional, Gimeno Blanes, JR., additional, De La Morena Valenzuela, G., additional, Takahashi, L., additional, Lopez Fernandez, T., additional, Irazusta Cordoba, FJ., additional, Rosillo Rodriguez, SO., additional, Dominguez Melcon, FJ., additional, Meras Colunga, P., additional, Gemma, D., additional, Moreno Gomez, R., additional, Moreno Yanguela, M., additional, Lopez Sendon, JL., additional, Nguyen, V., additional, Mathieu, T., additional, Kerneis, C., additional, Cimadevilla, C., additional, Kubota, N., additional, Codogno, I., additional, Tubiana, S., additional, Estrellat, C., additional, Vahanian, A., additional, Messika-Zeitoun, D., additional, Ondrus, T., additional, Van Camp, G., additional, Di Gioia, G., additional, Barbato, E., additional, Bartunek, J., additional, Penicka, M., additional, Johnsson, J., additional, Gomez, A., additional, Alam, M., additional, and Winter, R., additional
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- 2016
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16. EAE/ASE recommendations for the use of echocardiography in new transcatheter interventions for valvular heart disease
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Zamorano, Jl, Badano, Lp, Bruce, C, Chan, Kl, Gonçalves, A, Hahn, Rt, Keane, Mg, LA CANNA, G, Monaghan, Mj, Nihoyannopoulos, P, Silvestry, Fe, Vanoverschelde, Jl, Gillam, Ld, DOCUMENT REVIEWERS EUROPEAN ASSOCIATION OF ECHOCARDIOGRAPHY EAE, Vahanian, A, DI BELLO, Vitantonio, Buck, T, and AMERICAN SOCIETY OF ECHOCARDIOGRAPHY ASE THE ASE GUIDELINES AND STANDARDS COMMITTEE AND THE ASE BOARD OF DIRECTORS
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- 2011
17. Transcather aortic valve implantation supported by 3D trans-esophageal echocardiography: Should it become the standard?
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Baghai, M, primary, Monaghan, MJ, additional, El-Gamel, A, additional, MacCarthy, P, additional, Bhan, A, additional, Thomas, MR, additional, Wilson, K, additional, Alcock, E, additional, Kailasam, R, additional, and Wendler, O, additional
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- 2009
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18. Should we be using 3D transesophageal echocardiography instead of 2D for the assessment of aortic annular diameter in transcatheter aortic valve implantation?
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Bhan, A, primary, Kapetanakis, S, additional, Wilson, K, additional, Pearson, P, additional, Baghai, M, additional, El-Gamel, A, additional, MacCarthy, P, additional, Thomas, MR, additional, Monaghan, MJ, additional, and Wendler, O, additional
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- 2009
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19. Real-time three-dimensional echocardiography: a novel technique to quantify global left ventricular mechanical dyssynchrony.
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Kapetanakis S, Kearney MT, Siva A, Gall N, Cooklin M, Monaghan MJ, Kapetanakis, S, Kearney, M T, Siva, A, Gall, N, Cooklin, M, and Monaghan, M J
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- 2005
20. Science, medicine and the future: microbubble contrast agents: a new era in ultrasound.
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Blomley MJK, Cooke JC, Unger EC, Monaghan MJ, and Cosgrove DO
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- 2001
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21. Evaluation of myocardial, hepatic, and renal perfusion in a variety of clinical conditions using an intravenous ultrasound contrast agent (Optison) and second harmonic imaging.
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Hancock J, Dittrich H, Jewitt DE, Monaghan MJ, Hancock, J, Dittrich, H, Jewitt, D E, and Monaghan, M J
- Abstract
Objective: To assess the potential of intravenous Optison, a second generation ultrasound contrast agent, and various ultrasound imaging modes to determine myocardial, kidney, and liver perfusion in normal subjects and patients with left ventricular dysfunction or chronic pulmonary disease together with renal or hepatic dysfunction.Methods: Five normal subjects and 20 patients underwent grey scale echocardiographic imaging of myocardium, kidney, and liver during 505 intravenous injections of Optison. Images were assessed qualitatively by two independent observers and quantitatively using video densitometry to determine the peak contrast enhancement effect.Results: Qualitative analysis showed that intermittent harmonic imaging was superior to either conventional fundamental or continuous harmonic imaging for all organs. Quantitative analysis showed that the peak change in echocardiographic intensity v baseline during continuous harmonic imaging was 11 units for myocardium (p < 0.03), 7 units for kidney (NS), and 14 units for liver (p < 0.05). During intermittent harmonic imaging the peak change was significantly greater, being 33 units for myocardium (p < 0.0001), 24 units for kidney (p < 0.0002), and 16 units for liver (p < 0.001).Conclusions: Organ tissue perfusion can be demonstrated following intravenous injection of Optison, particularly when used in combination with intermittent harmonic imaging techniques. This contrast agent is effective in a variety of clinical conditions. [ABSTRACT FROM AUTHOR]- Published
- 1999
22. A guide for performing adult TTE: the British Society of Echocardiography minimum dataset
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Robinson, S, Rana, B, Oxborough, D, Steeds, RP, Monaghan, MJ, Stout, M, Pearce, K, Harkness, A, Ring, L, Paton, M, Akhtar, W, Bedair, R, Bhattacharyya, S, Collins, K, Oxley, C, Sandoval, J, Schofield, R, Anjana, S, Parker, K, Willis, J, and Augustine, DX
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RC1200 - Abstract
Since cardiac ultrasound was introduced into medical practice around the middle twentieth century, transthoracic echocardiography has developed to become a highly sophisticated and widely performed cardiac imaging modality in the diagnosis of heart disease1. This evolution from an emerging technique with limited application, into a complex modality capable of detailed cardiac assessment has been driven by technological innovations that have both refined 'standard' two dimensional and Doppler imaging and led to the development of new diagnostic techniques. Accordingly, the adult transthoracic echocardiogram has evolved to become a comprehensive assessment of complex cardiac anatomy, function and haemodynamics. This guideline protocol from the British Society of Echocardiography aims to outline the minimum dataset required to confirm normal cardiac structure and function when performing a comprehensive standard adult echocardiogram and is structured according to the recommended sequence of acquisition. It is recommended that this structured approach to image acquisition and measurement protocol forms the basis of every standard adult transthoracic echocardiogram. However, when pathology is detected and further analysis becomes necessary, views and measurements in addition to the minimum dataset are required and should be taken with reference to the appropriate British Society of Echocardiography imaging protocol. It is anticipated that the recommendations made within this guideline will help standardise the local, regional and national practice of echocardiography, in addition to minimising the inter and intra-observer variation associated with echocardiographic measurement and interpretation.
23. Cardiology trainees and coronary artery surgeons.
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Bhan A, Kapetanakis S, and Monaghan MJ
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- 2008
24. Is antibiotic prophylaxis ever necessary before transoesophageal echocardiography?
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Chambers JB, Klein JL, Bennett SR, Monaghan MJ, and Roxburgh JC
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Evidence strongly suggests that antibiotic prophylaxis should not be used routinely for transoesophageal echocardiography for any indication. [ABSTRACT FROM AUTHOR]
- Published
- 2006
25. Myocardial abscess: a rare complication of valvular endocarditis demonstrated by 3D contrast echocardiography.
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Walker N, Bhan A, Desai J, and Monaghan MJ
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- 2010
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26. Images in cardiology: Left ventricular non-compaction diagnosed by real time three dimensional echocardiography.
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Gopalamurugan AB, Kapetanakis S, Monaghan MJ, Murgatroyd F, Gopalamurugan, A B, Kapetanakis, S, Monaghan, M J, and Murgatroyd, F
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- 2005
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27. Poster session Friday 13 December - PM: 13/12/2013, 14:00-18:00 * Location: Poster area
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Caiani, EG, Pellegrini, A, Carminati, MC, Lang, RM, Auricchio, A, Vaida, P, Obase, K, Sakakura, T, Komeda, M, Okura, H, Yoshida, K, Zeppellini, R, Noni, M, Rigo, T, Erente, G, Carasi, M, Costa, A, Ramondo, BA, Thorell, L, Akesson-Lindow, T, Shahgaldi, K, Germanakis, I, Fotaki, A, Peppes, S, Sifakis, S, Parthenakis, F, Makrigiannakis, A, Richter, U, Sveric, K, Forkmann, M, Wunderlich, C, Strasser, RH, Djikic, D, Potpara, T, Polovina, M, Marcetic, Z, Peric, V, Ostenfeld, E, Werther-Evaldsson, A, Engblom, H, Ingvarsson, A, Roijer, A, Meurling, C, Holm, J, Radegran, G, Carlsson, M, Tabuchi, H, Yamanaka, T, Katahira, Y, Tanaka, M, Kurokawa, T, Nakajima, H, Ohtsuki, S, Saijo, Y, Yambe, T, Dalto, M, Romeo, E, Argiento, P, Dandrea, A, Vanderpool, R, Correra, A, Sarubbi, B, Calabro, R, Russo, MG, Naeije, R, Saha, S K, Warsame, T A, Caelian, A G, Malicse, M, Kiotsekoglou, A, Omran, A S, Sharif, D, Sharif-Rasslan, A, Shahla, C, Khalil, A, Rosenschein, U, Erturk, M, Oner, E, Kalkan, AK, Pusuroglu, H, Ozyilmaz, S, Akgul, O, Aksu, HU, Akturk, F, Celik, O, Uslu, N, Bandera, F, Pellegrino, M, Generati, G, Donghi, V, Alfonzetti, E, Guazzi, M, Rangel, I, Goncalves, A, Sousa, C, Correia, AS, Martins, E, Silva-Cardoso, J, Macedo, F, Maciel, MJ, Lee, S, Kim, W, Yun, H, Jung, L, Kim, E, Ko, J, Enescu, OA, Florescu, M, Rimbas, RC, Cinteza, M, Vinereanu, D, Kosmala, W, Rojek, A, Cielecka-Prynda, M, Laczmanski, L, Mysiak, A, Przewlocka-Kosmala, M, Liu, D, Hu, K, Niemann, M, Herrmann, S, Cikes, M, Gaudron, PD, Knop, S, Ertl, G, Bijnens, B, Weidemann, F, Saravi, M, Tamadoni, AHMAD, Jalalian, ROZITA, Hojati, MOSTAF, Ramezani, SAEED, Yildiz, A, Inci, U, Bilik, MZ, Yuksel, M, Oyumlu, M, Kayan, F, Ozaydogdu, N, Aydin, M, Akil, MA, Tekbas, E, Shang, Q, Zhang, Q, Fang, F, Wang, S, Li, R, Lee, A PW, Yu, CM, Mornos, C, Ionac, A, Cozma, D, Popescu, I, Ionescu, G, Dan, R, Petrescu, L, Sawant, AC, Srivatsa, SV, Adhikari, P, Mills, PK, Srivatsa, SS, Boshchenko, A, Vrublevsky, A, Karpov, R, Trifunovic, D, Stankovic, S, Vujisic-Tesic, B, Petrovic, M, Nedeljkovic, I, Banovic, M, Tesic, M, Petrovic, M, Dragovic, M, Ostojic, M, Zencirci, E, Esen Zencirci, A, Degirmencioglu, A, Karakus, G, Ekmekci, A, Erdem, A, Ozden, K, Erer, HB, Akyol, A, Eren, M, Zamfir, D, Tautu, O, Onciul, S, Marinescu, C, Onut, R, Comanescu, I, Oprescu, N, Iancovici, S, Dorobantu, M, Melao, F, Pereira, M, Ribeiro, V, Oliveira, S, Araujo, C, Subirana, I, Marrugat, J, Dias, P, Azevedo, A, study, EURHOBOP, Grillo, M T, Piamonti, B, Abate, E, Porto, A, Dellangela, L, Gatti, G, Poletti, A, Pappalardo, A, Sinagra, G, Pinto-Teixeira, P, Galrinho, A, Branco, L, Fiarresga, A, Sousa, L, Cacela, D, Portugal, G, Rio, P, Abreu, J, Ferreira, R, Fadel, B, Abdullah, N, Al-Admawi, M, Pergola, V, Bech-Hanssen, O, Di Salvo, G, Tigen, M K, Pala, S, Karaahmet, T, Dundar, C, Bulut, M, Izgi, A, Esen, A M, Kirma, C, Boerlage-Van Dijk, K, Yamawaki, M, Wiegerinck, EMA, Meregalli, PG, Bindraban, NR, Vis, MM, Koch, KT, Piek, JJ, Bouma, BJ, Baan, J, Mizia, M, Sikora-Puz, A, Gieszczyk-Strozik, K, Lasota, B, Chmiel, A, Chudek, J, Jasinski, M, Deja, M, Mizia-Stec, K, Silva Fazendas Adame, P R, Caldeira, D, Stuart, B, Almeida, S, Cruz, I, Ferreira, A, Lopes, L, Joao, I, Cotrim, C, Pereira, H, Unger, P, Dedobbeleer, C, Stoupel, E, Preumont, N, Argacha, JF, Berkenboom, G, Van Camp, G, Malev, E, Reeva, S, Vasina, L, Pshepiy, A, Korshunova, A, Timofeev, E, Zemtsovsky, E, Jorgensen, P G, Jensen, JS, Fritz-Hansen, T, Biering-Sorensen, T, Jons, C, Olsen, NT, Henri, C, Magne, J, Dulgheru, R, Laaraibi, S, Voilliot, D, Kou, S, Pierard, L, Lancellotti, P, Tayyareci, Y, Dworakowski, R, Kogoj, P, Reiken, J, Kenny, C, Maccarthy, P, Wendler, O, Monaghan, MJ, Song, JM, Ha, TY, Jung, YJ, Seo, MO, Choi, SA, Kim, YJ, Sun, BJ, Kim, DH, Kang, DH, Song, JK, Le Tourneau, T, Topilsky, Y, Inamo, J, Mahoney, D, Suri, R, Schaff, H, Enriquez-Sarano, M, Bonaque Gonzalez, JC, Sanchez Espino, AD, Merchan Ortega, G, Bolivar Herrera, N, Ikuta, I, Macancela Quinonez, JJ, Munoz Troyano, S, Ferrer Lopez, R, Gomez Recio, M, Dreyfus, J, Cimadevilla, C, Brochet, E, Himbert, D, Iung, B, Vahanian, A, Messika-Zeitoun, D, Izumo, M, Takeuchi, M, Seo, Y, Yamashita, E, Suzuki, K, Ishizu, T, Sato, K, Aonuma, K, Otsuji, Y, Akashi, YJ, Muraru, D, Addetia, K, Veronesi, F, Corsi, C, Mor-Avi, V, Yamat, M, Weinert, L, Lang, RM, Badano, LP, Minamisawa, M, Koyama, J, Kozuka, A, Motoki, H, Izawa, A, Tomita, T, Miyashita, Y, Ikeda, U, Florescu, C, Niemann, M, Liu, D, Hu, K, Herrmann, S, Gaudron, PD, Scholz, F, Stoerk, S, Ertl, G, Weidemann, F, Marchel, M, Serafin, A, Kochanowski, J, Piatkowski, R, Madej-Pilarczyk, A, Filipiak, KJ, Hausmanowa-Petrusewicz, I, Opolski, G, Meimoun, P, Mbarek, D, Clerc, J, Neikova, A, Elmkies, F, Tzvetkov, B, Luycx-Bore, A, Cardoso, C, Zemir, H, Mansencal, N, Arslan, M, El Mahmoud, R, Pilliere, R, Dubourg, O, Ikonomidis, I, Lambadiari, V, Pavlidis, G, Koukoulis, C, Kousathana, F, Varoudi, M, Tritakis, V, Triantafyllidi, H, Dimitriadis, G, Lekakis, I, Kovacs, A, Kosztin, A, Solymossy, K, Celeng, C, Apor, A, Faludi, M, Berta, K, Szeplaki, G, Foldes, G, Merkely, B, Kimura, K, Daimon, M, Nakajima, T, Motoyoshi, Y, Komori, T, Nakao, T, Kawata, T, Uno, K, Takenaka, K, Komuro, I, Gabric, I D, Vazdar, LJ, Pintaric, H, Planinc, D, Vinter, O, Trbusic, M, Bulj, N, Nobre Menezes, M, Silva Marques, J, Magalhaes, R, Carvalho, V, Costa, P, Brito, D, Almeida, AG, Nunes-Diogo, AG, Davidsen, E S, Bergerot, C, Ernande, L, Barthelet, M, Thivolet, S, Decker-Bellaton, A, Altman, M, Thibault, H, Moulin, P, Derumeaux, G, Huttin, O, Voilliot, D, Frikha, Z, Aliot, E, Venner, C, Juilliere, Y, Selton-Suty, C, Yamada, T, Ooshima, M, Hayashi, H, Okabe, S, Johno, H, Murata, H, Charalampopoulos, A, Tzoulaki, I, Howard, LS, Davies, RJ, Gin-Sing, W, Grapsa, J, Wilkins, MR, Gibbs, JSR, Castillo, JMDC, Bandeira, AMPB, Albuquerque, ESA, Silveira, C, Pyankov, V, Chuyasova, Y, Lichodziejewska, B, Goliszek, S, Kurnicka, K, Dzikowska Diduch, O, Kostrubiec, M, Krupa, M, Grudzka, K, Ciurzynski, M, Palczewski, P, Pruszczyk, P, Arana, X, Oria, G, Onaindia, JJ, Rodriguez, I, Velasco, S, Cacicedo, A, Palomar, S, Subinas, A, Zumalde, J, Laraudogoitia, E, Saeed, S, Kokorina, MV, Fromm, A, Oeygarden, H, Waje-Andreassen, U, Gerdts, E, Gomez, ELENA, Vallejo, NURIA, Pedro-Botet, LUISA, Mateu, LOURDE, Nunyez, RAQUEL, Llobera, LAIA, Bayes, ANTONI, Sabria, MIQUEL, Antonini-Canterin, F, Mateescu, AD, La Carrubba, S, Vriz, O, Di Bello, V, Carerj, S, Zito, C, Ginghina, C, Popescu, BA, Nicolosi, GL, Mateescu, AD, La Carrubba, S, Vriz, O, Di Bello, V, Carerj, S, Zito, C, Ginghina, C, Popescu, BA, Nicolosi, GL, Antonini-Canterin, F, Pudil, R, Praus, R, Vasatova, M, Vojacek, J, Palicka, V, Hulek, P, P37/03, Prvouk, Pradel, S, Mohty, D, Damy, T, Echahidi, N, Lavergne, D, Virot, P, Aboyans, V, Jaccard, A, Mateescu, AD, La Carrubba, S, Vriz, O, Di Bello, V, Carerj, S, Zito, C, Ginghina, C, Popescu, BA, Nicolosi, GL, Antonini-Canterin, F, Doulaptsis, C, Symons, R, Matos, A, Florian, A, Masci, PG, Dymarkowski, S, Janssens, S, Bogaert, J, Lestuzzi, C, Moreo, A, Celik, S, Lafaras, C, Dequanter, D, Tomkowski, W, De Biasio, M, Cervesato, E, Massa, L, Imazio, M, Watanabe, N, Kijima, Y, Akagi, T, Toh, N, Oe, H, Nakagawa, K, Tanabe, Y, Ikeda, M, Okada, K, Ito, H, Milanesi, O, Biffanti, R, Varotto, E, Cerutti, A, Reffo, E, Castaldi, B, Maschietto, N, Vida, VL, Padalino, M, Stellin, G, Bejiqi, R, Retkoceri, R, Bejiqi, H, Retkoceri, A, Surdulli, SH, Massoure, PL, Cautela, J, Roche, NC, Chenilleau, MC, Gil, JM, Fourcade, L, Akhundova, A, Cincin, A, Sunbul, M, Sari, I, Tigen, MK, Basaran, Y, Suermeci, G, Butz, T, Schilling, IC, Sasko, B, Liebeton, J, Van Bracht, M, Tzikas, S, Prull, MW, Wennemann, R, Trappe, HJ, Attenhofer Jost, C H, Pfyffer, M, Scharf, C, Seifert, B, Faeh-Gunz, A, Naegeli, B, Candinas, R, Medeiros-Domingo, A, Wierzbowska-Drabik, K, Roszczyk, N, Sobczak, M, Plewka, M, Krecki, R, Kasprzak, JD, Ikonomidis, I, Varoudi, M, Papadavid, E, Theodoropoulos, K, Papadakis, I, Pavlidis, G, Triantafyllidi, H, Anastasiou - Nana, M, Rigopoulos, D, Lekakis, J, Tereshina, O, Surkova, E, Vachev, A, Merchan Ortega, G, Bonaque Gonzalez, JC, Sanchez Espino, AD, Bolivar Herrera, N, Bravo Bustos, D, Ikuta, I, Aguado Martin, MJ, Navarro Garcia, F, Ruiz Lopez, F, Gomez Recio, M, Merchan Ortega, G, Bonaque Gonzalez, JC, Bravo Bustos, D, Sanchez Espino, AD, Bolivar Herrera, N, Bonaque Gonzalez, JJ, Navarro Garcia, F, Aguado Martin, MJ, Ruiz Lopez, MF, Gomez Recio, M, Eguchi, H, Maruo, T, Endo, K, Nakamura, K, Yokota, K, Fuku, Y, Yamamoto, H, Komiya, T, Kadota, K, Mitsudo, K, Nagy, A I, Manouras, AI, Gunyeli, E, Shahgaldi, K, Winter, R, Hoffmann, R, Barletta, G, Von Bardeleben, S, Kasprzak, J, Greis, C, Vanoverschelde, J, Becher, H, Hu, K, Liu, D, Niemann, M, Herrmann, S, Cikes, M, Gaudron, PD, Knop, S, Ertl, G, Bijnens, B, Weidemann, F, Di Salvo, G, Al Bulbul, Z, Issa, Z, Khan, AM, Faiz, AA, Rahmatullah, SH, Fadel, BM, Siblini, G, Al Fayyadh, M, Menting, M E, Van Den Bosch, AE, Mcghie, JS, Cuypers, JAAE, Witsenburg, M, Van Dalen, BM, Geleijnse, ML, Roos-Hesselink, JW, Olsen, FJ, Jorgensen, PG, Mogelvang, R, Jensen, JS, Fritz-Hansen, T, Bech, J, Biering-Sorensen, T, Agoston, G, Pap, R, Saghy, L, Forster, T, Varga, A, Scandura, S, Capodanno, D, Dipasqua, F, Mangiafico, S, Caggegi, A M, Grasso, C, Pistritto, A M, Imme, S, Ministeri, M, Tamburino, C, Cameli, M, Lisi, M, Dascenzi, F, Cameli, P, Losito, M, Sparla, S, Lunghetti, S, Favilli, R, Fineschi, M, Mondillo, S, Ojaghihaghighi, Z, Javani, B, Haghjoo, M, Moladoust, H, Shahrzad, S, Ghadrdoust, B, Altman, M, Aussoleil, A, Bergerot, C, Bonnefoy-Cudraz, E, Derumeaux, G A, Thibault, H, Shkolnik, E, Vasyuk, Y, Nesvetov, V, Shkolnik, L, Varlan, G, Gronkova, N, Kinova, E, Borizanova, A, Goudev, A, Saracoglu, E, Ural, D, Sahin, T, Al, N, Cakmak, H, Akbulut, T, Akay, K, Ural, E, Mushtaq, S, Andreini, D, Pontone, G, Bertella, E, Conte, E, Baggiano, A, Annoni, A, Formenti, A, Fiorentini, C, Pepi, M, Cosgrove, C, Carr, L, Chao, C, Dahiya, A, Prasad, S, Younger, JF, Biering-Sorensen, T, Christensen, LM, Krieger, DW, Mogelvang, R, Jensen, JS, Hojberg, S, Host, N, Karlsen, FM, Christensen, H, Medressova, A, Abikeyeva, L, Dzhetybayeva, S, Andossova, S, Kuatbayev, Y, Bekbossynova, M, Bekbossynov, S, Pya, Y, Farsalinos, K, Tsiapras, D, Kyrzopoulos, S, Spyrou, A, Stefopoulos, C, Romagna, G, Tsimopoulou, K, Tsakalou, M, Voudris, V, Cacicedo, A, Velasco Del Castillo, S, Anton Ladislao, A, Aguirre Larracoechea, U, Onaindia Gandarias, J, Romero Pereiro, A, Arana Achaga, X, Zugazabeitia Irazabal, G, Laraudogoitia Zaldumbide, E, Lekuona Goya, I, Varela, A, Kotsovilis, S, Salagianni, M, Andreakos, V, Davos, CH, Merchan Ortega, G, Bonaque Gonzalez, JC, Sanchez Espino, AD, Bolivar Herrera, N, Macancela Quinones, JJ, Ikuta, I, Ferrer Lopez, R, Munoz Troyano, S, Bravo Bustos, D, and Gomez Recio, M
- Abstract
Purpose: Cardiac deconditioning due to immobilization is a risk factor for cardiovascular disease. The physiology of cardiac adaptation to deconditioning has not been fully elucidated. The purpose of the present study was to assess the effects of 21-days of strict head-down (-6 degrees) bed-rest (BR) deconditioning on left ventricular (LV) dimensions and mass measured by MRI. Methods: Ten healthy men (mean age 32±6) were enrolled; the experiment was conducted at DLR (Koln, Germany) as part of the European Space Agency BR studies. Steady-state free precession MRI images (7mm thickness, no gap, no overlap) were obtained (Symphony 1.5T, Siemens) in a stack of short-axis views from LV base to LV apex, before (PRE), at the end of BR (HDT20), and four days after the BR conclusion (POST). Endocardial and epicardial semi-automated contouring was performed using freely available software (Segment). Results: At HDT20, significant reductions in LV mass (16%), end-diastolic (26%) and end-systolic (27%) volumes and stroke volume (27%) were observed, while ejection fraction did not change. These changes were accompanied by a measured decrease (14%) in plasma and blood volume (by gas-rebreathing technique), as well as by a significant reduction (14%) in VO2max aerobic power, measured using a graded cycle ergometer test protocol to volitional fatigue, at one day after the BR conclusion, while expiratory exchange ratio did not change. At POST, LV volumes were restored, while LV mass was still trending towards control values. Conclusions: Cardiac adaptation to deconditioning affected LV mass and dimensions, as a combined result of LV remodeling and fluids loss, accompanied by worsening in aerobic power. This should be taken into account in patients with cardiovascular diseases, when immobilized in bed, to proper adjust the therapy, or to define appropriate physical exercises when possible, in order to avoid further complications.
Cardiac MRI parameters PRE HDT20 POST LV mass (g) 121±6 102±11* 114±16 End-diastolic volume (ml) 119±25 90±14* 118±25 End-systolic volume (ml) 42±8 31±8* 45±14 Stroke volume (ml) 76±22 59±11* 73±15 Ejection fraction (%) 64±6 65±7 62±7 *: p<.01 vs PRE (one-way Anova for paired data and Tukey test) - Published
- 2013
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28. Moderated Posters session * Insights into the use of contrast stress echocardiography and 3D strain: 14/12/2013, 08:30-12:30 * Location: Moderated Poster area
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Muraru, D, Piasentini, E, Mihaila, S, Naso, P, Casablanca, S, Peluso, D, Denas, G, Ucci, L, Iliceto, S, Badano, LP, Abdel Moneim, S S, Kirby, B, Mendrick, E, Norby, B, Hagen, M, Basu, A, Mulvagh, SL, Chelliah, R, Whyte, G, Sharma, S, Pantazis, A, Senior, R, Grishenkov, D, Kothapalli, S, Gonon, A, Janerot-Sjoberg, B, Gianstefani, S, Maccarthy, PA, Rogers, T, Sen, A, Delithanasis, I, Reiken, J, Charangwa, L, Douiri, A, Monaghan, MJ, Bombardini, T, Sicari, R, Gherardi, S, Ciampi, Q, Pratali, L, Salvadori, S, Picano, E, Shivalkar, B, Belkova, P, Wouters, K, Van De Heyning, C, De Maeyer, C, Van Herck, P, Vrints, C, Voilliot, D, Magne, J, Dulgheru, R, Henri, C, Kou, S, Laaraibi, S, Sprynger, M, Andre, B, Pierard, L, Lancellotti, P, Federspiel, M, Oger, E, Fournet, M, Daudin, M, Thebault, C, Donal, E, Bombardini, T, Arpesella, G, Bernazzali, S, Potena, L, Serra, W, Del Bene, R, and Picano, E
- Abstract
Background: Differences in definitions and measurements of parameters describing left ventricular (LV) mechanics among vendors hamper the use of 3D deformation analysis for clinical and research purposes. Our aim was to identify the reference values for 3D LV function parameters using a vendor-independent DICOM-based software. Methods: In 235 healthy volunteers uniformly distributed across decades (44±14 years, range 18–76 years), 3D LV full volume data sets (35±6 vps) were acquired using a GE Vivid E9 scanner. Exclusion criteria were athletic training, pregnancy, body mass index > 30 kg/m2, and poor apical acoustic window. LV 3D parameters (including ejection fraction, strain parameters, systolic dyssynchrony index - SDI, twist and torsion) were analyzed offline using 4D LV Analysis software 3.1 (TomTec, D). Results: Physiologic ageing was associated with a significant increase in LV ejection fraction and torsion, LV circumferential and 3D strain, and with a less synchronous regional LV function (p<0.0001 for all, except p=0.01 for torsion). Women had higher LV ejection fractions and absolute values of longitudinal and 3D strain than men (Table), but also smaller LVs (EDV 55±9 vs 64±11 ml/m2) and lower blood pressure values (SBP 114±14 vs 128±13 mmHg, p<0.0001). LV torsional mechanics (twist 7.7 vs 6.4°, torsion 0.91 vs 0.83°/cm, p=NS) and synchronicity (SDI 5.2±1.3 vs 5.2±1.3%) were similar between genders. LV deformation also showed significant regional variations, strain values in LV basal region being significantly lower than in mid or apical regions (p<0.001 for all strains). Conclusions: This study is the first to report age- and gender-specific normative values for global LV systolic function and deformation assessed by a vendor-independent software. Our data may foster the use of 3DE for assessing LV myocardial function in multi-vendor echo labs.
Men (n=104) Women (n=133) p Age (years) 44±15 44±14 0.87 Heart rate (bpm) 67±10 68±10 0.28 Ejection fraction (%) 62±4 64±3 <0.0001 Global longitudinal strain (%) −21.4±2.5 −22.2±2.5 0.02 Global circumferential strain (%) −33.7±3.2 −34.4±3.3 0.11 Global 3D strain (%) −36.7±2.9 −37.5±3.9 0.03 - Published
- 2013
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29. Cardiac resynchronization therapy: Part 2--issues during and after device implantation and unresolved questions.
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Bax JJ, Abraham T, Barold SS, Breithardt OA, Fung JW, Garrigue S, Gorcsan J 3rd, Hayes DL, Kass DA, Knuuti J, Leclercq C, Linde C, Mark DB, Monaghan MJ, Nihoyannopoulos P, Schalij MJ, Stellbrink C, Yu CM, Bax, Jeroen J, and Abraham, Theodore
- Abstract
Encouraged by the clinical success of cardiac resynchronization therapy (CRT), the implantation rate has increased exponentially, although several limitations and unresolved issues of CRT have been identified. This review concerns issues that are encountered during implantation of CRT devices, including the role of electroanatomical mapping, whether CRT implantation should be accompanied by simultaneous atrioventricular nodal ablation in patients with atrial fibrillation, procedural complications, and when to consider surgical left ventricular lead positioning. Furthermore, (echocardiographic) CRT optimization and assessment of CRT benefits after implantation are highlighted. Also, controversial issues such as the potential value of CRT in patients with mild heart failure or narrow QRS complex are addressed. Finally, open questions concerning when to combine CRT with implantable cardioverter-defibrillator therapy and the cost-effectiveness of CRT are discussed. [ABSTRACT FROM AUTHOR]
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- 2005
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30. Cardiac resynchronization therapy: Part 1--issues before device implantation.
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Bax JJ, Abraham T, Barold SS, Breithardt OA, Fung JW, Garrigue S, Gorcsan J 3rd, Hayes DL, Kass DA, Knuuti J, Leclercq C, Linde C, Mark DB, Monaghan MJ, Nihoyannopoulos P, Schalij MJ, Stellbrink C, Yu CM, Bax, Jeroen J, and Abraham, Theodore
- Abstract
Cardiac resynchronization therapy (CRT) has been used extensively over the last years in the therapeutic management of patients with end-stage heart failure. Data from 4,017 patients have been published in eight large, randomized trials on CRT. Improvement in clinical end points (symptoms, exercise capacity, quality of life) and echocardiographic end points (systolic function, left ventricular size, mitral regurgitation) have been reported after CRT, with a reduction in hospitalizations for decompensated heart failure and an improvement in survival. However, individual results vary, and 20% to 30% of patients do not respond to CRT. At present, the selection criteria include severe heart failure (New York Heart Association functional class III or IV), left ventricular ejection fraction <35%, and wide QRS complex (>120 ms). Assessment of inter- and particularly intraventricular dyssynchrony as provided by echocardiography (predominantly tissue Doppler imaging techniques) may allow improved identification of potential responders to CRT. In this review a summary of the clinical and echocardiographic results of the large, randomized trials is provided, followed by an extensive overview on the currently available echocardiographic techniques for assessment of LV dyssynchrony. In addition, the value of LV scar tissue and venous anatomy for the selection of potential candidates for CRT are discussed. [ABSTRACT FROM AUTHOR]
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- 2005
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31. Similarities and Differences in Left Ventricular Size and Function among Races and Nationalities: Results of the World Alliance Societies of Echocardiography Normal Values Study
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Federico M. Asch, Tatsuya Miyoshi, Karima Addetia, Rodolfo Citro, Masao Daimon, Sameer Desale, Pedro Gutierrez Fajardo, Ravi R. Kasliwal, James N. Kirkpatrick, Mark J. Monaghan, Denisa Muraru, Kofo O. Ogunyankin, Seung Woo Park, Ricardo E. Ronderos, Anita Sadeghpour, Gregory M. Scalia, Masaaki Takeuchi, Wendy Tsang, Edwin S. Tucay, Ana Clara Tude Rodrigues, Amuthan Vivekanandan, Yun Zhang, Alexandra Blitz, Roberto M. Lang, Aldo D. Prado, Eduardo Filipini, Agatha Kwon, Samantha Hoschke-Edwards, Tania Regina Afonso, Babitha Thampinathan, Maala Sooriyakanthan, Tiangang Zhu, Zhilong Wang, Yingbin Wang, Mei Zhang, Yu Zhang, Lixue Yin, Shuang Li, R. Alagesan, S. Balasubramanian, R.V.A. Ananth, Manish Bansal, Luigi P. Badano, Chiara Palermo, Eduardo Bossone, Davide Di Vece, Michele Bellino, Tomoko Nakao, Takayuki Kawata, Megumi Hirokawa, Naoko Sawada, Yousuke Nabeshima, Hye Rim Yun, Ji-won Hwang, Dolapo Fasawe, Marcus Schreckenberg, Ricardo Ronderos, Gregory Scalia, V. Amuthan, Ravi Kasliwal, Pedro Gutierrez-Fajardo, James Kirkpatrick, Asch, F, Miyoshi, T, Addetia, K, Citro, R, Daimon, M, Desale, S, Fajardo, P, Kasliwal, R, Kirkpatrick, J, Monaghan, M, Muraru, D, Ogunyankin, K, Park, S, Ronderos, R, Sadeghpour, A, Scalia, G, Takeuchi, M, Tsang, W, Tucay, E, Tude Rodrigues, A, Vivekanandan, A, Zhang, Y, Blitz, A, Lang, R, Prado, A, Filipini, E, Kwon, A, Hoschke-Edwards, S, Afonso, T, Thampinathan, B, Sooriyakanthan, M, Zhu, T, Wang, Z, Wang, Y, Zhang, M, Yin, L, Li, S, Alagesan, R, Balasubramanian, S, Ananth, R, Bansal, M, Badano, L, Palermo, C, Bossone, E, Di Vece, D, Bellino, M, Nakao, T, Kawata, T, Hirokawa, M, Sawada, N, Nabeshima, Y, Yun, H, Hwang, J, Fasawe, D, Schreckenberg, M, Amuthan, V, Gutierrez-Fajardo, P, Woo Park, S, Asch, Fm, Fajardo, Pg, Kasliwal, Rr, Kirkpatrick, Jn, Monaghan, Mj, Ogunyankin, Ko, Park, Sw, Ronderos, Re, Scalia, Gm, Rodrigues, Act, Lang, Rm, Prado, Ad, Afonso, Tr, Zhu, Tg, Wang, Zl, Wang, Yb, Yin, Lx, Ananth, Rva, Badano, Lp, Yun, Hr, and Hwang, Jw
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Adult ,Male ,medicine.medical_specialty ,Longitudinal strain ,Multiracial ,Heart Ventricles ,Normal values ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,Normal value ,030218 nuclear medicine & medical imaging ,Age and gender ,03 medical and health sciences ,0302 clinical medicine ,Reference Values ,Interquartile range ,Internal medicine ,Ethnicity ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Societies, Medical ,Aged ,WASE ,Body surface area ,Ejection fraction ,business.industry ,Racial Groups ,Left ventricular size ,Stroke Volume ,Organ Size ,Middle Aged ,Left ventricle ,United States ,Cross-Sectional Studies ,Echocardiography ,International ,Cardiology ,Female ,Core laboratory ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background: The World Alliance Societies of Echocardiography (WASE) Normal Values Study evaluates individuals from multiple countries and races with the aim of describing normative values that could be applied to the global community worldwide and to determine differences and similarities among people from different countries and races. The present report focuses specifically on two-dimensional (2D) left ventricular (LV) dimensions, volumes, and systolic function. Methods: The WASE Normal Values Study is a multicenter international, observational, prospective, cross-sectional study of healthy adult individuals. Participants recruited in each country were evenly distributed among six predetermined subgroups according to age and gender. Comprehensive 2D transthoracic echocardiograms were acquired and analyzed following strict protocols based on recent American Society of Echocardiography and European Association of Cardiovascular Imaging guidelines. Analysis was performed at the WASE 2D core laboratory and included 2D LV dimensions, LV volumes, and LV ejection fraction (LVEF) by the biplane Simpson method and global longitudinal strain (GLS). Results: Two thousand eight subjects were enrolled in 15 countries. The median age was 45 years (interquartile range, 32–65 years), 42.8% were white, 41.8% were Asian, and 9.7% were black. LV dimensions and volumes were larger in male subjects, while LVEF and GLS were higher in female subjects. Global WASE normal ranges for LV dimensions were smaller than those in the guidelines, but the upper limits of normal for LV volumes and the lower limits of normal for LVEF were higher in the WASE study. Significant intercountry variation was identified for all LV parameters reflecting LV size (dimensions, mass, and volumes) even after indexing to body surface area, with LV end-diastolic and end-systolic volumes having the highest variation. The largest volumes were noted in Australia, while the smallest were measured in India for both genders. This finding suggests that in addition to gender and body surface area, specific country should be considered when evaluating LV volumes. Intercountry variation for LVEF and GLS was smaller but still statistically significant (P < .05 for all). Conclusions: LV dimensions and volumes are larger in men, while LVEF and GLS are higher in women. Current guideline-recommended normal ranges for LV volumes and LVEF should be adjusted. Intercountry variability is significant for LV volumes, and therefore nationality should be considered for defining ranges of normality.
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- 2019
32. Three-dimensional printing in modelling mitral valve interventions.
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Bharucha AH, Moore J, Carnahan P, MacCarthy P, Monaghan MJ, Baghai M, Deshpande R, Byrne J, Dworakowski R, and Eskandari M
- Abstract
Mitral interventions remain technically challenging owing to the anatomical complexity and heterogeneity of mitral pathologies. As such, multi-disciplinary pre-procedural planning assisted by advanced cardiac imaging is pivotal to successful outcomes. Modern imaging techniques offer accurate 3D renderings of cardiac anatomy; however, users are required to derive a spatial understanding of complex mitral pathologies from a 2D projection thus generating an 'imaging gap' which limits procedural planning. Physical mitral modelling using 3D printing has the potential to bridge this gap and is increasingly being employed in conjunction with other transformative technologies to assess feasibility of intervention, direct prosthesis choice and avoid complications. Such platforms have also shown value in training and patient education. Despite important limitations, the pace of innovation and synergistic integration with other technologies is likely to ensure that 3D printing assumes a central role in the journey towards delivering personalised care for patients undergoing mitral valve interventions., (© 2023. The Author(s).)
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- 2023
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33. Normal Values of Three-Dimensional Right Ventricular Size and Function Measurements: Results of the World Alliance Societies of Echocardiography Study.
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Addetia K, Miyoshi T, Amuthan V, Citro R, Daimon M, Gutierrez Fajardo P, Kasliwal RR, Kirkpatrick JN, Monaghan MJ, Muraru D, Ogunyankin KO, Park SW, Ronderos RE, Sadeghpour A, Scalia GM, Takeuchi M, Tsang W, Tucay ES, Tude Rodrigues AC, Zhang Y, Singulane CC, Hitschrich N, Blankenhagen M, Degel M, Schreckenberg M, Mor-Avi V, Asch FM, and Lang RM
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- Male, Humans, Female, Aged, Reference Values, Reproducibility of Results, Stroke Volume, Echocardiography, Ventricular Function, Right, Heart Ventricles diagnostic imaging, Echocardiography, Three-Dimensional methods
- Abstract
Background: Normal values for three-dimensional (3D) right ventricular (RV) size and function are not well established, as they originate from small studies that involved predominantly white North American and European populations, did not use RV-focused views, and relied on older 3D RV analysis software. The World Alliance Societies of Echocardiography study was designed to generate reference ranges for normal subjects around the world. The aim of this study was to assess the worldwide capability of 3D imaging of the right ventricle and report size and function measurements, including their dependency on age, sex, and ethnicity., Methods: Healthy subjects free of cardiac, pulmonary, and renal disease were prospectively enrolled at 19 centers in 15 countries, representing six continents. Three-dimensional wide-angle RV data sets were obtained and analyzed using dedicated RV software (TomTec) to measure end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume, and ejection fraction (EF). Results were categorized by sex, age (18-40, 41-65, and >65 years) and ethnicity., Results: Of the 2,007 subjects with attempted 3D RV acquisitions, 1,051 had adequate image quality for confident measurements. Upper and lower limits for body surface area-indexed EDV, ESV, and EF were 48 and 95 mL/m
2 , 19 and 43 mL/m2 , and 44% and 58%, respectively, for men and 42 and 81 mL/m2 , 16 and 36 mL/m2 , and 46% and 61%, respectively, for women. Men had significantly larger EDVs, ESVs, and stroke volumes (even after body surface area indexing) and lower EFs than women (P < .05). EDV and ESV did not show any meaningful differences among age groups. Three-dimensional RV volumes were smallest in Asians., Conclusions: Reliability of 3D RV acquisition is low worldwide, underscoring the importance of future improvements in imaging techniques. Sex and race must be taken into consideration in the assessment of both RV volumes and EF., (Copyright © 2023 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.)- Published
- 2023
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34. Age-, Sex-, and Race-Based Normal Values for Left Ventricular Circumferential Strain from the World Alliance Societies of Echocardiography Study.
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Singulane CC, Miyoshi T, Mor-Avi V, Cotella JI, Schreckenberg M, Blankenhagen M, Hitschrich N, Addetia K, Amuthan V, Citro R, Daimon M, Gutiérrez-Fajardo P, Kasliwal R, Kirkpatrick JN, Monaghan MJ, Muraru D, Ogunyankin KO, Park SW, Tude Rodrigues AC, Ronderos R, Sadeghpour A, Scalia GM, Takeuchi M, Tsang W, Tucay ES, Zhang Y, Asch FM, and Lang RM
- Subjects
- Adult, Male, Humans, Female, Middle Aged, Reference Values, Echocardiography methods, Heart Ventricles diagnostic imaging, Healthy Volunteers, Ventricular Function, Left, Ventricular Dysfunction, Left
- Abstract
Background: Left ventricular (LV) circumferential strain has received less attention than longitudinal deformation, which has recently become part of routine clinical practice. Among other reasons, this is because of the lack of established normal values. Accordingly, the aim of this study was to establish normative values for LV circumferential strain and determine sex-, age-, and race-related differences in a large cohort of healthy adults., Methods: Complete two-dimensional transthoracic echocardiograms were obtained in 1,572 healthy subjects (51% men), enrolled in the World Alliance Societies of Echocardiography Normal Values Study. Subjects were divided into three age groups (<35, 35-55, and >55 years) and stratified by sex and by race. Vendor-independent semiautomated speckle-tracking software was used to determine LV regional circumferential strain and global circumferential strain (GCS) values. Limits of normal for each measurement were defined as 95% of the corresponding sex and age group falling between the 2.5th and 97.5th percentiles. Intergroup differences were analyzed using unpaired t tests., Results: Circumferential strain showed a gradient, with lower magnitude at the mitral valve level, increasing progressively toward the apex. Compared with men, women had statistically higher magnitudes of regional and global strain. Older age was associated with a stepwise increase in GCS despite an unaffected ejection fraction, a decrease in LV volume, and relatively stable global longitudinal strain in men, with a small gradual decrease in women. Asian subjects demonstrated significantly higher GCS magnitudes than whites of both sexes and blacks among women only. In contrast, no significant differences in GCS were found between white and black subjects of either sex. Importantly, despite statistical significance of these differences across sex, age, and race, circumferential strain values were similar in all groups, with variations of the order of magnitude of 1% to 2%. Notably, no differences in GCS were found among brands of imaging equipment., Conclusion: This study established normal values of LV regional circumferential strain and GCS and identified sex-, age-, and race-related differences when present., (Copyright © 2022 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.)
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- 2023
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35. Normal Values of Left Ventricular Mass by Two-Dimensional and Three-Dimensional Echocardiography: Results from the World Alliance Societies of Echocardiography Normal Values Study.
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Lee L, Cotella JI, Miyoshi T, Addetia K, Schreckenberg M, Hitschrich N, Blankenhagen M, Amuthan V, Citro R, Daimon M, Gutiérrez-Fajardo P, Kasliwal R, Kirkpatrick JN, Monaghan MJ, Muraru D, Ogunyankin KO, Park SW, Tude Rodrigues AC, Ronderos R, Sadeghpour A, Scalia GM, Takeuchi M, Tsang W, Tucay ES, Zhang M, Mor-Avi V, Asch FM, and Lang RM
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- Adult, Male, Middle Aged, Humans, Female, Aged, Adolescent, Young Adult, Reference Values, Hypertrophy, Left Ventricular, Echocardiography, Ventricular Function, Left, Heart Ventricles diagnostic imaging, Echocardiography, Three-Dimensional methods
- Abstract
Background: Although increased left ventricular (LV) mass is associated with adverse outcomes, measured values vary widely depending on the specific technique used. Moreover, the impact of sex, age, and race on LV mass remains controversial, further limiting the clinical use of this parameter. Accordingly, the authors studied LV mass using a variety of two-dimensional and three-dimensional echocardiographic techniques in a large population of normal subjects encompassing a wide range of ages., Methods: Transthoracic echocardiograms obtained from 1,854 healthy adult subjects (52% men) enrolled in the World Alliance Societies of Echocardiography (WASE) Normal Values Study, were divided into three age groups (young, 18-35 years; middle aged, 36-55 years; and old, >55 years). LV mass was obtained using five conventional techniques, including linear and two-dimensional methods, as well as direct three-dimensional measurement. All LV mass values were indexed to body surface area, and differences according to sex, age, and race were analyzed for each technique., Results: LV mass values differed significantly among the five techniques. Three-dimensional measurements were considerably smaller than those obtained using the other techniques and were closer to magnetic resonance imaging normal values reported in the literature. For all techniques, LV mass in men was significantly larger than in women, with and without body surface area indexing. These technique- and sex-related differences were larger than measurement variability. In women, age differences in LV mass were more pronounced and depicted significantly larger values in older age groups for all techniques, except three-dimensional echocardiography, which showed essentially no differences. LV mass was overall larger in black subjects than in white or Asian subjects., Conclusions: Significant differences in LV mass values exist across echocardiographic techniques, which are therefore not interchangeable. Sex-, race-, and age-related differences underscore the need for separate population specific normal values., (Copyright © 2022 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.)
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- 2023
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36. Normative values of the aortic valve area and Doppler measurements using two-dimensional transthoracic echocardiography: results from the Multicentre World Alliance of Societies of Echocardiography Study.
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Cotella JI, Miyoshi T, Mor-Avi V, Addetia K, Schreckenberg M, Sun D, Slivnick JA, Blankenhagen M, Hitschrich N, Amuthan V, Citro R, Daimon M, Gutiérrez-Fajardo P, Kasliwal R, Kirkpatrick JN, Monaghan MJ, Muraru D, Ogunyankin KO, Park SW, Tude Rodrigues AC, Ronderos R, Sadeghpour A, Scalia G, Takeuchi M, Tsang W, Tucay ES, Zhang M, Prado AD, Asch FM, and Lang RM
- Subjects
- Male, Humans, Female, Aged, Echocardiography methods, Ultrasonography, Doppler, Heart Ventricles diagnostic imaging, Aortic Valve diagnostic imaging, Aortic Valve Stenosis diagnostic imaging
- Abstract
Aims: Aortic valve area (AVA) used for echocardiographic assessment of aortic stenosis (AS) has been traditionally interpreted independently of sex, age and race. As differences in normal values might impact clinical decision-making, we aimed to establish sex-, age- and race-specific normative values for AVA and Doppler parameters using data from the World Alliance Societies of Echocardiography (WASE) Study., Methods and Results: Two-dimensional transthoracic echocardiographic studies were obtained from 1903 healthy adult subjects (48% women). Measurements of the left ventricular outflow tract (LVOT) diameter and Doppler parameters, including AV and LVOT velocity time integrals (VTIs), AV mean pressure gradient, peak velocity, were obtained according to ASE/EACVI guidelines. AVA was calculated using the continuity equation. Compared with men, women had smaller LVOT diameters and AVA values, and higher AV peak velocities and mean gradients (all P < 0.05). LVOT and AV VTI were significantly higher in women (P < 0.05), and both parameters increased with age in both sexes. AVA differences persisted after indexing to body surface area. According to the current diagnostic criteria, 13.5% of women would have been considered to have mild AS and 1.4% moderate AS. LVOT diameter and AVA were lower in older subjects, both men and women, and were lower in Asians, compared with whites and blacks., Conclusion: WASE data provide clinically relevant information about significant differences in normal AVA and Doppler parameters according to sex, age, and race. The implementation of this information into clinical practice should involve development of specific normative values for each ethnic group using standardized methodology., Competing Interests: Conflict of interest: M.S., M.B. and N.H. are employees of TOMTEC Imaging Systems. No other direct conflicts of Interest related to this study have been reported by any of the authors., (© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
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- 2023
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37. Human versus Artificial Intelligence-Based Echocardiographic Analysis as a Predictor of Outcomes: An Analysis from the World Alliance Societies of Echocardiography COVID Study.
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Asch FM, Descamps T, Sarwar R, Karagodin I, Singulane CC, Xie M, Tucay ES, Tude Rodrigues AC, Vasquez-Ortiz ZY, Monaghan MJ, Ordonez Salazar BA, Soulat-Dufour L, Alizadehasl A, Mostafavi A, Moreo A, Citro R, Narang A, Wu C, Addetia K, Upton R, Woodward GM, and Lang RM
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- Humans, Stroke Volume, Artificial Intelligence, Echocardiography methods, Ventricular Function, Left, COVID-19 diagnosis
- Abstract
Background: Transthoracic echocardiography is the leading cardiac imaging modality for patients admitted with COVID-19, a condition of high short-term mortality. The aim of this study was to test the hypothesis that artificial intelligence (AI)-based analysis of echocardiographic images could predict mortality more accurately than conventional analysis by a human expert., Methods: Patients admitted to 13 hospitals for acute COVID-19 who underwent transthoracic echocardiography were included. Left ventricular ejection fraction (LVEF) and left ventricular longitudinal strain (LVLS) were obtained manually by multiple expert readers and by automated AI software. The ability of the manual and AI analyses to predict all-cause mortality was compared., Results: In total, 870 patients were enrolled. The mortality rate was 27.4% after a mean follow-up period of 230 ± 115 days. AI analysis had lower variability than manual analysis for both LVEF (P = .003) and LVLS (P = .005). AI-derived LVEF and LVLS were predictors of mortality in univariable and multivariable regression analysis (odds ratio, 0.974 [95% CI, 0.956-0.991; P = .003] for LVEF; odds ratio, 1.060 [95% CI, 1.019-1.105; P = .004] for LVLS), but LVEF and LVLS obtained by manual analysis were not. Direct comparison of the predictive value of AI versus manual measurements of LVEF and LVLS showed that AI was significantly better (P = .005 and P = .003, respectively). In addition, AI-derived LVEF and LVLS had more significant and stronger correlations to other objective biomarkers of acute disease than manual reads., Conclusions: AI-based analysis of LVEF and LVLS had similar feasibility as manual analysis, minimized variability, and consequently increased the statistical power to predict mortality. AI-based, but not manual, analyses were a significant predictor of in-hospital and follow-up mortality., (Copyright © 2022 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.)
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- 2022
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38. The impact of complete versus partial preservation of the sub-valvular apparatus on left ventricular function in mitral valve replacement.
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Ng Yin Ling C, Avci Demir F, Bleetman D, Eskandari M, Khan H, Baghai M, Deshpande R, Monaghan MJ, and Wendler O
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- Humans, Middle Aged, Mitral Valve diagnostic imaging, Mitral Valve surgery, Ventricular Function, Left, Retrospective Studies, Stroke Volume, Mitral Valve Insufficiency diagnostic imaging, Mitral Valve Insufficiency surgery, Mitral Valve Insufficiency complications, Ventricular Dysfunction, Left etiology, Heart Valve Prosthesis Implantation methods
- Abstract
Introduction: In mitral valve replacement (MVR), sudden increases in afterload and disruption of the annular-chordal-papillary-left-ventricular wall causes left ventricular (LV) dysfunction in the early postoperative period. Preservation of the posterior mitral leaflet apparatus (MVR-P) has a favorable outcome on LV function. However, there is paucity of data on the impact of complete preservation of the sub-valvular apparatus (MVR-C)., Objective: We investigated the impact of MVR-P and MVR-C on baseline and 3-months postoperative LV ejection fraction (EF) and global longitudinal strain (GLS)., Methods: We retrospectively analyzed a cohort of 29 MVR-P and 19 MVR-C patients with complete echocardiography data at our unit, who were operated between 2008 and 2017. Between-group changes in LVEF and GLS were compared using independent sample T-test., Results: Median age was 59 years (IQR 50-69 years). Baseline LVEF was 58% (51%- 60%). Baseline GLS was -18.4 (-21.2 to -15.5). There were no significant between-group differences between all baseline demographics and echocardiographic markers. There was significantly higher absolute postoperative LVEF in MVR-C patients (p = 0.029). There was also significant worsening in LVEF (p = 0.0121) and GLS (p < 0.0001) after MVR-P and not MVR-C, suggesting no reduction in LV function post-MVR-C but a reduction post-MVR-P. There was significantly less postoperative worsening of GLS per patient in MVR-C group as compared to the MVR-P group (p = 0.023), indicating better preservation of LV function. There was also a smaller decline in LVEF per patient in the MVR-C as compared to the MVR-P group, although not statistically significant (p = 0.23)., Conclusion: MVR with complete preservation of the sub-valvular apparatus shows a favorable impact on the longitudinal function of the heart at 3 months. Further studies with larger patient numbers are indicated to investigate the long-term results of this surgical approach., (© 2022 The Authors. Journal of Cardiac Surgery published by Wiley Periodicals LLC.)
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- 2022
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39. Power Modulation Echocardiography to Detect and Quantify Myocardial Scar.
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Papachristidis A, Theodoropoulos KC, Marvaki A, Queirós S, D'hooge J, Masoero G, Pagnano G, Huang M, Dancy L, Sado D, Shah AM, Murgatroyd FD, and Monaghan MJ
- Subjects
- Humans, Gadolinium, Contrast Media pharmacology, Prospective Studies, Predictive Value of Tests, Myocardium pathology, Echocardiography methods, Magnetic Resonance Imaging methods, Magnetic Resonance Imaging, Cine methods, Cicatrix diagnostic imaging, Myocardial Infarction complications, Myocardial Infarction diagnosis
- Abstract
Background: Myocardial scar correlates with clinical outcomes. Traditionally, late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) is used to detect and quantify scar. In this prospective study using LGE CMR as reference, the authors hypothesized that nonlinear ultrasound imaging, namely, power modulation, can detect and quantify myocardial scar in selected patients with previous myocardial infarction. In addition, given the different histopathology between ischemic and nonischemic scar, a further aim was to test the diagnostic performance of this echocardiographic technique in unselected consecutive individuals with ischemic and nonischemic LGE or no LGE on CMR., Methods: Seventy-one patients with previous myocardial infarction underwent power modulation echocardiography following CMR imaging (group A). Subsequently, 101 consecutive patients with or without LGE on CMR, including individuals with nonischemic LGE, were scanned using power modulation echocardiography (group B)., Results: In group A, echocardiography detected myocardial scar in all 71 patients, with good scar volume agreement with CMR (bias = -1.9 cm
3 ; limits of agreement [LOA], -8.0 to 4.2 cm3 ). On a per-segment basis, sensitivity was 82%, specificity 97%, and accuracy 92%. Sensitivity was higher in the inferior and posterior segments and lower in the anterior and lateral walls. In group B, on a per-subject basis, the sensitivity of echocardiography was 62% (91% for ischemic and 30% for nonischemic LGE), with specificity and accuracy of 89% and 72%, respectively. The bias for scar volume between modalities was 5.9 cm3 , with LOA of 34.6 to 22.9 cm3 (bias = -1.9 cm3 [LOA, -11.4 to 7.6 cm3 ] for ischemic LGE, and bias = 18.9 cm3 [LOA, -67.4 to 29.7.6 cm3 ] for nonischemic LGE)., Conclusions: Power modulation echocardiography can detect myocardial scar in both selected and unselected individuals with previous myocardial infarction and has good agreement for scar volume quantification with CMR. In an unselected cohort with nonischemic LGE, sensitivity is low., (Copyright © 2022 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.)- Published
- 2022
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40. A concise history of echocardiography: timeline, pioneers, and landmark publications.
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Fraser AG, Monaghan MJ, van der Steen AFW, and Sutherland GR
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- Aged, Child, Humans, Cardiology, Echocardiography
- Abstract
Echocardiography is less than 70 years old, and many major advances have occurred within living memory, but already some pioneering contributions may be overlooked. In order to consider what circumstances have been common to the most successful innovations, we have studied and here provide a timeline and summary of the most important developments in transthoracic and transoesophageal ultrasound imaging and Doppler techniques, as well as in intravascular ultrasound and imaging in paediatric cardiology. The entries are linked to a comprehensive list of first publications and to a collection of first-hand historical accounts published by early investigators. Review of the original manuscripts highlights that it is difficult to establish unequivocal precedence for many new imaging methods, since engineers were often working independently but simultaneously on similar problems. Many individuals who are prominently linked with particular developments were not the first in their field. Developments in echocardiography have been highly dependent on technological advances, and most likely to be successful when engineers and clinicians were able to collaborate with open exchange between centres and disciplines. As with many other new medical technologies, initial responses were sceptical and introduction into clinical practice required persistence and substantial energy from the first adopters. Current developments involve advances in software as much as in equipment, and progress will depend on continuing collaborations between engineers and clinical scientists, for example to identify unmet needs and to investigate the clinical impact of particular imaging approaches., Competing Interests: Conflict of interest: None declared., (© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.)
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- 2022
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41. Three-Dimensional Transthoracic Static and Dynamic Normative Values of the Mitral Valve Apparatus: Results from the Multicenter World Alliance Societies of Echocardiography Study.
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Henry MP, Cotella J, Mor-Avi V, Addetia K, Miyoshi T, Schreckenberg M, Blankenhagen M, Hitschrich N, Amuthan V, Citro R, Daimon M, Gutiérrez-Fajardo P, Kasliwal R, Kirkpatrick JN, Monaghan MJ, Muraru D, Ogunyankin KO, Park SW, Tude Rodrigues AC, Ronderos R, Sadeghpour A, Scalia G, Takeuchi M, Tsang W, Tucay ES, Zhang M, Lang RM, and Asch FM
- Subjects
- Adolescent, Adult, Echocardiography, Echocardiography, Transesophageal methods, Female, Humans, Male, Mitral Valve diagnostic imaging, Software, Young Adult, Echocardiography, Three-Dimensional methods, Mitral Valve Insufficiency
- Abstract
Background: Recent advances in mitral valve (MV) percutaneous interventions have escalated the need for a more quantitative and comprehensive assessment of the MV, which can be best achieved using three-dimensional echocardiography. Understanding normal valve size, structure, and function is essential for differentiation of healthy from disease states. The aims of this study were to establish normative values for MV apparatus size and morphology and to determine how they vary across age, sex, and race groups using data from the World Alliance Societies of Echocardiography Normal Values Study., Methods: Three-dimensional volumetric data sets obtained on transthoracic echocardiography in 748 normal subjects (51% men) were analyzed using commercial MV analysis software (TomTec Imaging Systems) to determine annular and leaflet dimensions and areas. The subjects were divided into groups by sex (378 men and 370 women) and age (18 to 40 years [n = 266], 41 to 65 years [n = 249], and >65 years [n = 233]) to identify sex- and age-related differences. In addition, differences among black, white, and Asian populations were studied. Inter- and intraobserver variability was assessed in a subset of 30 subjects and expressed as mean absolute difference between pairs of repeated measurements., Results: Compared with women, men had larger annular size measurements, larger tenting size parameters, and larger leaflet length and area. Compared with the black and white populations, the Asian population showed significantly smaller mitral annular size. Although many of the age, sex, and race differences in MV parameters were statistically significant, they were comparable with or smaller than the corresponding measurement variability. Indexing to body surface area and height did not eliminate these differences consistently, suggesting that parameters may need to be indexed according to their dimensionality., Conclusions: This analysis of the World Alliance Societies of Echocardiography data provides normative values of mitral apparatus size and morphology. Although sex- and age-related differences were noted, they need to be interpreted with caution in view of the associated measurement variability., (Copyright © 2022 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.)
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- 2022
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42. Effect of Transcatheter Aortic Valve Implantation vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis: A Randomized Clinical Trial.
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Toff WD, Hildick-Smith D, Kovac J, Mullen MJ, Wendler O, Mansouri A, Rombach I, Abrams KR, Conroy SP, Flather MD, Gray AM, MacCarthy P, Monaghan MJ, Prendergast B, Ray S, Young CP, Crossman DC, Cleland JGF, de Belder MA, Ludman PF, Jones S, Densem CG, Tsui S, Kuduvalli M, Mills JD, Banning AP, Sayeed R, Hasan R, Fraser DGW, Trivedi U, Davies SW, Duncan A, Curzen N, Ohri SK, Malkin CJ, Kaul P, Muir DF, Owens WA, Uren NG, Pessotto R, Kennon S, Awad WI, Khogali SS, Matuszewski M, Edwards RJ, Ramesh BC, Dalby M, Raja SG, Mariscalco G, Lloyd C, Cox ID, Redwood SR, Gunning MG, and Ridley PD
- Subjects
- Aged, Aged, 80 and over, Aortic Valve surgery, Aortic Valve Insufficiency etiology, Female, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation adverse effects, Heart Valve Prosthesis Implantation methods, Heart Valve Prosthesis Implantation mortality, Humans, Male, Risk Factors, Treatment Outcome, Aortic Valve Stenosis mortality, Aortic Valve Stenosis surgery, Transcatheter Aortic Valve Replacement adverse effects, Transcatheter Aortic Valve Replacement mortality
- Abstract
Importance: Transcatheter aortic valve implantation (TAVI) is a less invasive alternative to surgical aortic valve replacement and is the treatment of choice for patients at high operative risk. The role of TAVI in patients at lower risk is unclear., Objective: To determine whether TAVI is noninferior to surgery in patients at moderately increased operative risk., Design, Setting, and Participants: In this randomized clinical trial conducted at 34 UK centers, 913 patients aged 70 years or older with severe, symptomatic aortic stenosis and moderately increased operative risk due to age or comorbidity were enrolled between April 2014 and April 2018 and followed up through April 2019., Interventions: TAVI using any valve with a CE mark (indicating conformity of the valve with all legal and safety requirements for sale throughout the European Economic Area) and any access route (n = 458) or surgical aortic valve replacement (surgery; n = 455)., Main Outcomes and Measures: The primary outcome was all-cause mortality at 1 year. The primary hypothesis was that TAVI was noninferior to surgery, with a noninferiority margin of 5% for the upper limit of the 1-sided 97.5% CI for the absolute between-group difference in mortality. There were 36 secondary outcomes (30 reported herein), including duration of hospital stay, major bleeding events, vascular complications, conduction disturbance requiring pacemaker implantation, and aortic regurgitation., Results: Among 913 patients randomized (median age, 81 years [IQR, 78 to 84 years]; 424 [46%] were female; median Society of Thoracic Surgeons mortality risk score, 2.6% [IQR, 2.0% to 3.4%]), 912 (99.9%) completed follow-up and were included in the noninferiority analysis. At 1 year, there were 21 deaths (4.6%) in the TAVI group and 30 deaths (6.6%) in the surgery group, with an adjusted absolute risk difference of -2.0% (1-sided 97.5% CI, -∞ to 1.2%; P < .001 for noninferiority). Of 30 prespecified secondary outcomes reported herein, 24 showed no significant difference at 1 year. TAVI was associated with significantly shorter postprocedural hospitalization (median of 3 days [IQR, 2 to 5 days] vs 8 days [IQR, 6 to 13 days] in the surgery group). At 1 year, there were significantly fewer major bleeding events after TAVI compared with surgery (7.2% vs 20.2%, respectively; adjusted hazard ratio [HR], 0.33 [95% CI, 0.24 to 0.45]) but significantly more vascular complications (10.3% vs 2.4%; adjusted HR, 4.42 [95% CI, 2.54 to 7.71]), conduction disturbances requiring pacemaker implantation (14.2% vs 7.3%; adjusted HR, 2.05 [95% CI, 1.43 to 2.94]), and mild (38.3% vs 11.7%) or moderate (2.3% vs 0.6%) aortic regurgitation (adjusted odds ratio for mild, moderate, or severe [no instance of severe reported] aortic regurgitation combined vs none, 4.89 [95% CI, 3.08 to 7.75])., Conclusions and Relevance: Among patients aged 70 years or older with severe, symptomatic aortic stenosis and moderately increased operative risk, TAVI was noninferior to surgery with respect to all-cause mortality at 1 year., Trial Registration: isrctn.com Identifier: ISRCTN57819173.
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- 2022
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43. Unexpected finding after aortic arch operation: a left ventricular pseudoaneurysm - Who is the culprit?
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Denman E, Marvaki A, Huang M, Lamas S, Harrison J, Ammar T, Deshpande R, Monaghan MJ, and Papachristidis A
- Subjects
- Aorta, Thoracic diagnostic imaging, Aorta, Thoracic surgery, Echocardiography, Female, Heart Ventricles diagnostic imaging, Heart Ventricles pathology, Humans, Middle Aged, Tomography, X-Ray Computed, Aneurysm, False diagnosis
- Abstract
We present a case of a 61-year-old female who, after undergoing frozen elephant trunk surgery, was found to have an unexpected left ventricular pseudoaneurysm on transthoracic echocardiogram. The pseudoaneurysm was caused by the left ventricular vent catheter constantly impinging the LV wall of the beating heart during surgery. Contrast echocardiography, cardiac magnetic resonance imaging and computed tomography (CT) imaging confirmed the diagnosis and served for follow-up demonstrating the narrow neck and outpouching structure on the apical lateral wall. The patient remains asymptomatic two years after the operation and is being followed up with echocardiography and CT imaging., (© 2022 Wiley Periodicals LLC.)
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- 2022
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44. Normal Values of Left Ventricular Size and Function on Three-Dimensional Echocardiography: Results of the World Alliance Societies of Echocardiography Study.
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Addetia K, Miyoshi T, Amuthan V, Citro R, Daimon M, Gutierrez Fajardo P, Kasliwal RR, Kirkpatrick JN, Monaghan MJ, Muraru D, Ogunyankin KO, Park SW, Ronderos RE, Sadeghpour A, Scalia GM, Takeuchi M, Tsang W, Tucay ES, Tude Rodrigues AC, Zhang Y, Hitschrich N, Blankenhagen M, Degel M, Schreckenberg M, Mor-Avi V, Asch FM, and Lang RM
- Subjects
- Aged, Echocardiography methods, Female, Heart Ventricles diagnostic imaging, Humans, Male, Middle Aged, Reference Values, Stroke Volume, Ventricular Function, Left, Echocardiography, Three-Dimensional methods, Ventricular Dysfunction, Left
- Abstract
Background: Echocardiography remains the most widely used modality to assess left ventricular (LV) chamber size and function. Currently this assessment is most frequently performed using two-dimensional (2D) echocardiography. However, three-dimensional (3D) echocardiography has been shown to be more accurate and reproducible than 2D echocardiography. Current normative reference values for 3D LV analysis are based predominantly on data from North America and Europe. The World Alliance Societies of Echocardiography study was designed to sample normal subjects from around the world to provide more universal global reference ranges. The aim of this study was to assess the worldwide feasibility of LV 3D echocardiography and report on size and functional measurements., Methods: A total of 2,262 healthy subjects were prospectively enrolled from 19 centers in 15 countries. Three-dimensional LV full-volume data sets were obtained and analyzed offline using vendor-neutral software. Measurements included LV end-diastolic and end-systolic volumes, LV ejection fraction (LVEF), global longitudinal strain (GLS), and global circumferential strain. Results were categorized by age (18-40, 41-65, and >65 years), sex, and race., Results: A total of 1,589 subjects (feasibility 70%) had adequate LV data sets for analysis. Mean normal values for indexed end-diastolic volume, end-systolic volume, and LVEF in men and women were 70 ± 15 and 65 ± 12 mL/m
2 , 28 ± 7 and 25 ± 6 mL/m2 , and 60 ± 5% and 62 ± 5%, respectively. Men had larger LV volumes and lower LVEFs than women. GLS and global circumferential strain were higher in magnitude in women. In both sexes, LV volumes were lower and LVEF tended to be higher with increasing age, especially considering the differences between the youngest and oldest age groups. Although GLS was similar across age groups in men, in women, the youngest and middle-age cohorts revealed higher magnitudes of GLS compared with the oldest age group. Global circumferential strain was higher in magnitude at older age in both men and women. Finally, Asians had smaller chamber sizes and higher LVEFs and absolute strain values than both blacks and whites., Conclusions: Age, sex, and race should be considered when defining normal reference values for LV dimension and functional parameters obtained by 3D echocardiography., (Copyright © 2021 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.)- Published
- 2022
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45. Sex-, Age-, and Race-Related Normal Values of Right Ventricular Diastolic Function Parameters: Data from the World Alliance Societies of Echocardiography Study.
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Carvalho Singulane C, Singh A, Miyoshi T, Addetia K, Soulat-Dufour L, Schreckenberg M, Blankenhagen M, Hitschrich N, Amuthan V, Citro R, Daimon M, Gutiérrez-Fajardo P, Kasliwal R, Kirkpatrick JN, Monaghan MJ, Muraru D, Ogunyankin KO, Park SW, Tude Rodrigues AC, Ronderos R, Sadeghpour A, Scalia GM, Takeuchi M, Tsang W, Tucay ES, Zhang Y, Mor-Avi V, Asch FM, and Lang RM
- Subjects
- Aged, Diastole, Echocardiography, Female, Humans, Male, Reference Values, Heart Ventricles diagnostic imaging, Ventricular Function, Right
- Abstract
Background: Although the assessment of right ventricular (RV) diastolic function is feasible, it has garnered far less momentum for use compared with its left ventricular counterpart. The scarcity of data defining normative RV diastolic function and the fact that implications of RV diastolic dysfunction in different disease states on outcomes are less well known both hinder integration into routine clinical assessment. The aim of this study was to establish normal values of RV diastolic parameters stratified by sex, age, and race using data from the World Alliance Societies of Echocardiography study., Methods: A subset of 888 normal subjects from the World Alliance Societies of Echocardiography database were analyzed, including measurements of tricuspid valve (TV) inflow E- and A-wave velocities, E-wave deceleration time, and TV annular tissue Doppler e' and a' velocities. Additionally, right atrial (RA) maximal volume and RA peak reservoir strain were measured. Patients were grouped by age (<40, 41-65, and >65 years) and stratified by sex and race. Differences were analyzed using unpaired t tests., Results: Compared with men, women had significantly higher TV e' and E-wave and A-wave velocities, though differences were modest. Increasing age was associated with stepwise lower TV E wave, e' velocity, and TV E/A ratio and higher a' velocity and E/e' ratio. RA peak reservoir strain was also lower, and RA end-systolic volume trended toward being smaller for older age groups. Asian subjects demonstrated significantly higher a' velocities, lower E wave, the smallest RA end-systolic volumes, and the lowest RA peak strain values compared with white subjects of both sexes., Conclusions: This study provides normal values for parameters used in the assessment of RV diastolic function stratified by race, sex, and age. The results demonstrate significant differences in RV diastolic parameters between age groups, which manifest in both individual parameters and composite ratios of TV inflow and annular velocities. Although limited sex- and race-related differences were also noted, age appears to have the most significant impact on RV diastolic parameters. These findings may aid in refining current normative values., (Copyright © 2021 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
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46. Normal Values of Aortic Root Size According to Age, Sex, and Race: Results of the World Alliance of Societies of Echocardiography Study.
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Patel HN, Miyoshi T, Addetia K, Citro R, Daimon M, Gutierrez Fajardo P, Kasliwal RR, Kirkpatrick JN, Monaghan MJ, Muraru D, Ogunyankin KO, Park SW, Ronderos RE, Sadeghpour A, Scalia GM, Takeuchi M, Tsang W, Tucay ES, Tude Rodrigues AC, Amuthan V, Zhang Y, Schreckenberg M, Blankenhagen M, Degel M, Hitschrich N, Mor-Avi V, Asch FM, and Lang RM
- Subjects
- Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Racial Groups, Reference Values, White People, Young Adult, Aorta diagnostic imaging, Echocardiography
- Abstract
Background: Accurate measurements of the aortic annulus and root are important for guiding therapeutic decisions regarding the need for aortic surgery. Current echocardiographic guidelines for identification of aortic root dilatation are limited because current normative values were derived predominantly from white individuals in narrow age ranges, and based partially on M-mode measurements. Using data from the World Alliance Societies of Echocardiography study, the authors sought to establish normal ranges of aortic dimensions across sexes, races, and a wide range of ages., Methods: Adult individuals free of heart, lung, and kidney disease were prospectively enrolled from 15 countries, with even distributions among sexes and age groups: young (18-40 years), middle aged (41-65 years) and old (>65 years). Transthoracic two-dimensional echocardiograms of 1,585 subjects (mean age, 47 ± 17 years; 50.4% men; mean body surface area [BSA], 1.77 ± 0.22 m
2 ) were analyzed in a core laboratory following American Society of Echocardiography guidelines. Measurements, indexed separately by BSA and by height, included the aortic annulus, sinuses of Valsalva, and sinotubular junction. Differences among age, sex, and racial groups were evaluated using unpaired two-tailed Student's t tests., Results: All aortic root dimensions were larger in men compared with women. After indexing to BSA, all measured dimensions were significantly larger in women, whereas men continued to show larger dimensions after indexing to height. Of note, the upper limits of normal for all aortic dimensions were lower across all age groups, compared with the guidelines. Aortic dimensions were larger in older age groups in both sexes, a trend that persisted regardless of BSA or height adjustment. Last, differences in aortic dimensions were also observed according to race: Asians had the smallest nonindexed aortic dimensions at all levels., Conclusions: There are significant differences in aortic dimensions according to sex, age, and race. Thus, current guideline-recommended normal ranges may need to be adjusted to account for these differences., (Copyright © 2021 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.)- Published
- 2022
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47. Ventricular Changes in Patients with Acute COVID-19 Infection: Follow-up of the World Alliance Societies of Echocardiography (WASE-COVID) Study.
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Karagodin I, Singulane CC, Descamps T, Woodward GM, Xie M, Tucay ES, Sarwar R, Vasquez-Ortiz ZY, Alizadehasl A, Monaghan MJ, Ordonez Salazar BA, Soulat-Dufour L, Mostafavi A, Moreo A, Citro R, Narang A, Wu C, Addetia K, Tude Rodrigues AC, Lang RM, and Asch FM
- Subjects
- Echocardiography methods, Follow-Up Studies, Heart Ventricles diagnostic imaging, Humans, SARS-CoV-2, Stroke Volume, Ventricular Function, Left, Ventricular Function, Right, COVID-19 complications
- Abstract
Background: COVID-19 infection is known to cause a wide array of clinical chronic sequelae, but little is known regarding the long-term cardiac complications. We aim to report echocardiographic follow-up findings and describe the changes in left (LV) and right ventricular (RV) function that occur following acute infection., Methods: Patients enrolled in the World Alliance Societies of Echocardiography-COVID study with acute COVID-19 infection were asked to return for a follow-up transthoracic echocardiogram. Overall, 198 returned at a mean of 129 days of follow-up, of which 153 had paired baseline and follow-up images that were analyzable, including LV volumes, ejection fraction (LVEF), and longitudinal strain (LVLS). Right-sided echocardiographic parameters included RV global longitudinal strain, RV free wall strain, and RV basal diameter. Paired echocardiographic parameters at baseline and follow-up were compared for the entire cohort and for subgroups based on the baseline LV and RV function., Results: For the entire cohort, echocardiographic markers of LV and RV function at follow-up were not significantly different from baseline (all P > .05). Patients with hyperdynamic LVEF at baseline (>70%), had a significant reduction of LVEF at follow-up (74.3% ± 3.1% vs 64.4% ± 8.1%, P < .001), while patients with reduced LVEF at baseline (<50%) had a significant increase (42.5% ± 5.9% vs 49.3% ± 13.4%, P = .02), and those with normal LVEF had no change. Patients with normal LVLS (<-18%) at baseline had a significant reduction of LVLS at follow-up (-21.6% ± 2.6% vs -20.3% ± 4.0%, P = .006), while patients with impaired LVLS at baseline had a significant improvement at follow-up (-14.5% ± 2.9% vs -16.7% ± 5.2%, P < .001). Patients with abnormal RV global longitudinal strain (>-20%) at baseline had significant improvement at follow-up (-15.2% ± 3.4% vs -17.4% ± 4.9%, P = .004). Patients with abnormal RV basal diameter (>4.5 cm) at baseline had significant improvement at follow-up (4.9 ± 0.7 cm vs 4.6 ± 0.6 cm, P = .019)., Conclusions: Overall, there were no significant changes over time in the LV and RV function of patients recovering from COVID-19 infection. However, differences were observed according to baseline LV and RV function, which may reflect recovery from the acute myocardial injury occurring in the acutely ill. Left ventricular and RV function tends to improve in those with impaired baseline function, while it tends to decrease in those with hyperdynamic LV or normal RV function., (Copyright © 2021 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
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48. Normal Values of Left Atrial Size and Function and the Impact of Age: Results of the World Alliance Societies of Echocardiography Study.
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Singh A, Carvalho Singulane C, Miyoshi T, Prado AD, Addetia K, Bellino M, Daimon M, Gutierrez Fajardo P, Kasliwal RR, Kirkpatrick JN, Monaghan MJ, Muraru D, Ogunyankin KO, Park SW, Ronderos RE, Sadeghpour A, Scalia GM, Takeuchi M, Tsang W, Tucay ES, Tude Rodrigues AC, Vivekanandan A, Zhang Y, Schreckenberg M, Blankenhagen M, Degel M, Hitschrich N, Mor-Avi V, Asch FM, and Lang RM
- Subjects
- Adolescent, Adult, Atrial Function, Left, Echocardiography, Female, Heart Atria diagnostic imaging, Humans, Male, Reference Values, Young Adult, Atrial Appendage, Echocardiography, Three-Dimensional
- Abstract
Background: Left atrial (LA) evaluation includes volumetric and functional parameters with an abundance of diagnostic and prognostic implications. Solid normal reference ranges are compulsory for accurate interpretation in individual patients, but previous studies have yielded mixed conclusions regarding the effects of age, sex, and/or race. The present report from the World Alliance Societies of Echocardiography study focuses on two-dimensional (2D) and three-dimensional (3D) measures of LA structure and function, with subgroup analysis by age, sex, and race., Methods: Transthoracic 2D and 3D echocardiographic images were obtained in 1,765 healthy individuals (901 men, 864 women) evenly distributed among age subgroups: 18 to 40 years (n = 745), 41 to 65 years (n = 618), and >65 years (n = 402); the racial distribution was 38.4% white, 39.9% Asian, and 9.7% black. Images were analyzed using dedicated LA analysis software to measure LA volumes and phasic function from 3D volume and 2D strain curves., Results: Three-dimensional maximum and minimum LA volumes adjusted for body surface area were nearly identical for men and women, but women demonstrated higher 3D total and passive emptying fractions (EFs). Two-dimensional reservoir strain was similar for both sexes. Age was associated with an incremental rise in LA volumes alongside characteristic shifts in functional indices. Total 2D EF and reservoir and conduit strain varied inversely with age, counteracted by higher booster strain, with a greater magnitude of effect in women. Active 3D EF was significantly higher, while total and passive EFs decreased with age. Interracial differences were noted in LA volumes, without substantial differences in functional indices., Conclusion: Although similar normal values for LA volumes and strain can be applied to both sexes, meaningful differences in LA size occur with aging. Indices of function also shift with age, with a compensatory rise in booster function, which may serve to counteract observed lower total and passive EFs. Defining age-associated normal values may help differentiate age-associated "healthy" LA aging from pathologic processes., (Copyright © 2021 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
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49. Screening for subclinical rheumatic heart disease: addressing borderline disease in a real-world setting.
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Hunter LD, Pecoraro AJK, Doubell AF, Monaghan MJ, Lloyd GW, Lombard CJ, and Herbst PG
- Abstract
Aims: The World Heart Federation (WHF) criteria identify a large borderline rheumatic heart disease (RHD) category that has hampered the implementation of population-based screening. Inter-scallop separations (ISS) of the posterior mitral valve leaflet, a recently described normal variant of the mitral valve, appears to be an important cause of mild mitral regurgitation (MR) leading to misclassification of cases as WHF 'borderline RHD'. This study aims to report the findings of the Echo in Africa project, a large-scale RHD screening project in South Africa and determine what proportion of borderline cases would be re-classified as normal if there were a systematic identification of ISS-related MR., Methods and Results: A prospective cross-sectional study of underserved secondary schools in the Western Cape was conducted. Participants underwent a screening study with a handheld (HH) ultrasound device. Children with an abnormal HH study were re-evaluated with a portable laptop echocardiography machine. A mechanistic evaluation was applied in cases with isolated WHF 'pathological' MR (WHF 'borderline RHD'). A total of 5255 participants (mean age 15± years) were screened. A total of 3439 (65.8%) were female. Forty-nine cases of WHF 'definite RHD' [9.1 cases/1000 (95% confidence interval, CI, 6.8-12.1 cases/1000)] and 104 cases of WHF 'borderline RHD' [19.5 cases/1000 (95% CI, 16.0-23.7 cases/1000)] were identified. Inter-scallop separations-related MR was the underlying mechanism of MR in 48/68 cases classified as WHF 'borderline RHD' with isolated WHF 'pathological' MR (70.5%)., Conclusion: In a real-world, large-scale screening project, the adoption of a mechanistic evaluation based on the systematic identification of ISS-related MR markedly reduced the number of WHF 'screen-positive' cases misclassified as WHF 'borderline RHD'. Implementing strategies that reduce this misclassification could reduce the cost- and labour burden on large-scale RHD screening programmes., (© The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.)
- Published
- 2021
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50. Two-Dimensional Echocardiographic Right Ventricular Size and Systolic Function Measurements Stratified by Sex, Age, and Ethnicity: Results of the World Alliance of Societies of Echocardiography Study.
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Addetia K, Miyoshi T, Citro R, Daimon M, Gutierrez Fajardo P, Kasliwal RR, Kirkpatrick JN, Monaghan MJ, Muraru D, Ogunyankin KO, Park SW, Ronderos RE, Sadeghpour A, Scalia GM, Takeuchi M, Tsang W, Tucay ES, Tude Rodrigues AC, Vivekanandan A, Zhang Y, Schreckenberg M, Mor-Avi V, Asch FM, and Lang RM
- Subjects
- Adult, Aged, Echocardiography, Female, Heart Ventricles diagnostic imaging, Humans, Male, Middle Aged, Ventricular Function, Right, Ethnicity, Ventricular Dysfunction, Right
- Abstract
Background: Echocardiographic assessment of right ventricular (RV) systolic function is an important component of clinical decision making. Although professional societies have worked to define normal ranges of RV size and function, their guidelines have not included the impacts of age, sex, and ethnicity on these parameters, as they have for the left ventricle. The World Alliance of Societies of Echocardiography study was designed to investigate the effects of age, sex, and ethnicity on all cardiac chambers. The aim of this study was to explore whether these differences exist for RV systolic parameters., Methods: Adequate two-dimensional RV-focused views for the measurement of systolic parameters, including fractional area change and global and free wall longitudinal strain, were available in 1,913 subjects (mean age, 47 ± 17 years; 51% men). Basal and mid-RV dimensions, length, tricuspid annular peak systolic excursion, tissue Doppler S' velocity, and myocardial performance index were also measured. Subjects were grouped by age (<40, 41-65, and >65 years), with results also stratified by sex and ethnicity (Asian, black, or white) and analyzed using vendor-independent software. Differences among groups were evaluated using analysis of variance., Results: Women had smaller absolute and indexed RV areas and absolute RV dimensions and higher magnitudes of fractional area change, free wall strain, and global longitudinal strain compared to men. With respect to age, most of the statistically significant differences were noted between the <40- and >65-year age groups, with RV areas and lengths smaller in older age groups and RV functional parameters (S', fractional area change, tricuspid annular plane systolic excursion, global longitudinal strain, free wall strain, and myocardial performance index) showing minimal decreases or no changes with age. Although there were no meaningful differences in functional parameters among ethnic groups, RV size was smallest in Asians., Conclusions: These findings suggest that although two-dimensional RV parameters are age and sex dependent, association with race is less apparent, excepting that the Asian population appears to have smaller chamber sizes compared with whites and blacks., (Copyright © 2021 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
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