1,961 results on '"Monaco F."'
Search Results
2. The effect of differences in trial design on estimates of efficacy of olanzapine in randomized studies
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Rotella, F., Falone, A., Cassioli, E., Mannucci, E., Ricca, V., and Del Monaco, F.
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- 2024
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3. Artificial Intelligence and Pain Medicine: an Introduction [Letter]
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Cascella M, Monaco F, and Piazza O
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Medicine (General) ,R5-920 - Abstract
Marco Cascella,1 Federica Monaco,2 Ornella Piazza1 1Anesthesia and Pain Medicine, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Baronissi, 84081, Italy; 2Anesthesia and Pain Management, ASL NA/1, Naples, ItalyCorrespondence: Marco Cascella, Anesthesia and Pain Medicine, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Via S. Allende, Baronissi, 84081, Italy, Email m.cascella@istitutotumori.na.it; mcascella@unisa.it
- Published
- 2024
4. High power ECRH and ECCD in moderately collisional ASDEX Upgrade Hmodes and status of EC system upgrade
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Stober J., Sommer F., Angioni C., Bock A., Fable E., Leuterer F., Monaco F., Müller F., Münich S., Petzold B., Poli E., Schubert M., Schütz H., Wagner D., Zohm H., Kasparek W., Plaum B., Meier A., Scherer Th., Strauß D., Jelonnek J., Thumm M., Litvak A., Denisov G.G., Chirkov A.V., Tai E.M., Popov L.G., Nichiporenko V.O., Myasnikov V.E., Soluyanova E.A., and Malygin V.
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Physics ,QC1-999 - Abstract
This contribution deals with H-modes with significant heat exchange between electrons and ions, but which can still show large differences between electron and ion-temperatures especially inside half minor radius. These conditions are referred to as moderately collisional. A systematic study shows that an increasing fraction of electron heating increases the transport in the ion channel mainly due to the dependence of the ITG dominated ion transport on the ratio Te/Ti in agreement with modeling. The rotational shear in the plasmas under study was so small that it hardly influences ITG stability, such that variations of the rotation profile due to a change of the heating method were of minor importance. These findings connect to studies of advanced tokamak scenarios using ECCD as a tool to modify the q-profile. The electron heating connected to the ECCD tends to increase the transport in the ion channel quite in contrast to the goal to operate at reduced current but with increased confinement. The confinement only increases as the fraction of ion heating is increased by adding more NBI. An ITER case was modeled as well. Due to the larger value of νei ・ τE the ratio Te/Ti is only moderately reduced even with strong electron heating and the confinement reduction is small even for the hypothetic case of using only ECRH as additional heating. Finally the paper discusses the ongoing upgrade of the AUG ECRH-system.
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- 2015
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5. Development of Resonant Diplexers for high-power ECRH – Status, Applications, Plans
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Kasparek W., Plaum B., Lechte C., Wu Z., Wang H., Maraschek M., Stober J., Wagner D., Reich M., Schubert M., Grünwald G., Monaco F., Müller S., Schütz H., Erckmann V., Doelman N., van den Braber R., Klop W., van den Brand H., Bongers W., Krijger B., Petelin M., Koposova E., Lubyako L., Bruschi A., and Sakamoto K.
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Physics ,QC1-999 - Abstract
The development of diplexers for ECRH has been pursued at a number of institutes because of their attractive variety of applications: Power combination, non-mechanical, electrically controlled switching (of combined beams) between launchers with tens of kHz, and discrimination of low-power ECE signals from high-power ECRH is feasible. In a first part, this paper reports on plasma experiments with a ring resonator (Mk IIa) at ASDEX Upgrade. Commissioning experiments on fast switching between two launchers for synchronous stabilization of neoclassical tearing modes, as well as in-line ECE measurements have been performed, and experimental issues and first results are discussed. A clear influence of the switching phase on the amplitude of the 3/2 NTM mode was measured, complete stabilization could, however, not be demonstrated yet mainly due to imperfect resonator control. Concepts for improved tracking of the diplexers to the gyrotron frequency are presented. In a second part, the design of diplexers with ring resonators matched to HE11 fields is briefly discussed; these devices can be connected to corrugated waveguides without any mode converters. A compact version (MQ IV) is under investigation, which is compatible with the ITER ECRH system (170 GHz, 63.5 mm waveguide, vacuum tight casing), with the final goal of high-power tests at the 170 GHz gyrotron facility at JAEA in Naka, Japan. First low-power test results are presented.
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- 2015
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6. Feedback-controlled NTM stabilization on ASDEX Upgrade
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Stober J., Barrera L., Behler K., Bock A., Buhler A., Eixenberger H., Giannone L., Kasparek W., Maraschek M., Mlynek A., Monaco F., Poli E., Rapson C.J., Reich M., Schubert M., Treutterer W., Wagner D., and Zohm H.
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Physics ,QC1-999 - Abstract
On ASDEX Upgrade a concept for real-time stabilization of NTMs has been realized and successfully applied to (3,2)- and (2,1)-NTMs. Since most of the work has meanwhile been published elsewhere, a short summary with the appropriate references is given. Limitations, deficits and future extensions of the system are discussed. In a second part the recent work on using modulated ECCD for NTM stabilisation is described in some detail. In these experiments ECCD power is modulated according to a magnetic footprint of the rotating NTM. In agreement with earlier results it could be shown that O-point heating reduces the necessary average power for stabilisation whereas X-point heating hampers stabilisation. Although this modulated scheme is not relevant for routine NTM stabilisation on ASDEX Upgrade it may be mandatory for ITER or DEMO. On ASDEX Upgrade it has been re-developed to demonstrate the usage of a FAst DIrectional Switch to continously heat the O-point of the rotating island with only one gyrotron switching between two launchers which target the mode at locations separated in phase by 180 degrees as described in [1].
- Published
- 2015
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7. A Multifrequency Notch Filter for Millimeter Wave Plasma Diagnostics based on Photonic Bandgaps in Corrugated Circular Waveguides
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Wagner D., Bongers W., Kasparek W., Leuterer F., Monaco F., Münich M., Schütz H., Stober J., Thumm M., and Brand H. v.d.
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Physics ,QC1-999 - Abstract
Sensitive millimeter wave diagnostics need often to be protected against unwanted radiation like, for example, stray radiation from high power Electron Cyclotron Heating applied in nuclear fusion plasmas. A notch filter based on a waveguide Bragg reflector (photonic band-gap) may provide several stop bands of defined width within up to two standard waveguide frequency bands. A Bragg reflector that reflects an incident fundamental TE11 into a TM1n mode close to cutoff is combined with two waveguide tapers to fundamental waveguide diameter. Here the fundamental TE11 mode is the only propagating mode at both ends of the reflector. The incident TE11 mode couples through the taper and is converted to the high order TM1n mode by the Bragg structure at the specific Bragg resonances. The TM1n mode is trapped in the oversized waveguide section by the tapers. Once reflected at the input taper it will be converted back into the TE11 mode which then can pass through the taper. Therefore at higher order Bragg resonances, the filter acts as a reflector for the incoming TE11 mode. Outside of the Bragg resonances the TE11 mode can propagate through the oversized waveguide structure with only very small Ohmic attenuation compared to propagating in a fundamental waveguide. Coupling to other modes is negligible in the non-resonant case due to the small corrugation amplitude (typically 0.05·λ0, where λ0 is the free space wavelength). A Bragg reflector for 105 and 140 GHz was optimized by mode matching (scattering matrix) simulations and manufactured by SWISSto12 SA, where the required mechanical accuracy of ± 5 μm could be achieved by stacking stainless steel rings, manufactured by micro-machining, in a high precision guiding pipe. The two smooth-wall tapers were fabricated by electroforming. Several measurements were performed using vector network analyzers from Agilent (E8362B), ABmm (MVNA 8-350) and Rohde&Schwarz (ZVA24) together with frequency multipliers. The stop bands around 105 GHz (- 55dB) and 140 GHz (-60dB) correspond to the TE11-TM12 and TE11-TM13 Bragg resonances. Experiments are in good agreement with theory.
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- 2015
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8. Commissioning of inline ECE system within waveguide based ECRH transmission systems on ASDEX upgrade
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Donné A.J.H., Amerongen F.J., de Baar M.R., Meo F., van den Brand H., van den Braber R., Doelman N., Kasparek W., Bongers W.A., Elzendoorn B.S.Q., Erckmann V., Goede A.P.H., Giannone L., Grünwald G., Hollman F., Kaas G., Krijger B., Michel G., Lubyako L., Monaco F., Noke F., Petelin M., Plaum B., Purps F., ten Pierik J.G.W, Schüller C., Slob J.W., Stober J.K., Schütz H., Wagner D., Westerhof E., and Ronden D.M.S.
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Physics ,QC1-999 - Abstract
A CW capable inline electron cyclotron emission (ECE) separation system for feedback control, featuring oversized corrugated waveguides, is commissioned on ASDEX upgrade (AUG). The system is based on a combination of a polarization independent, non-resonant, Mach-Zehnder diplexer equipped with dielectric plate beam splitters [2, 3] employed as corrugated oversized waveguide filter, and a resonant Fast Directional Switch, FADIS [4, 5, 6, 7] as ECE/ECCD separation system. This paper presents an overview of the system, the low power characterisation tests and first high power commissioning on AUG.
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- 2012
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9. Status of Resonant Diplexer Development for high-power ECRH Applications
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Bongers W., Fritz E., Doelman N., van den Braber R., Wagner D., Stober J., Schütz H., Schubert M, Purps F., Noke F., Müller S., Monaco F., Michel G., Maraschek M., Hollmann F., Grünwald G., Erckmann V., Filipovic E., Lechte C., Plaum B., Kasparek W., Krijger B., Petelin M., Lubyako L., Bruschi A., and Sakamoto K.
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Physics ,QC1-999 - Abstract
Characteristics of ring resonator diplexers for high-power ECRH are briefly reviewed. Commissioning experiments performed on ASDEX Upgrade with the diplexer Mk IIa are presented, which demonstrate slow and fast switching of the power between two launchers, and thus the capability for efficient suppression of neoclassical tearing modes and simultaneous central heating of the plasma. The development of the compact diplexer Mk IIIb is discussed, and test results are presented. Finally, an evacuated design for 170 GHz is shown.
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- 2012
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10. Controlled Mirror Motion System for Resonant Diplexers in ECRH Applications
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Monaco F., Maraschek M., de Baar M., Purps F., Noke F., Michel G., Hollmann F., Klop W., Dekker B., Fritz E., Stober J., Krijger B., Bongers W., Erckmann V., Kasparek W., van den Braber R., Doelman N., Müller S., Schütz H., and Wagner D.
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Physics ,QC1-999 - Abstract
High-power resonant diplexers for millimetre waves have various promising applications in ECRH systems. The round-trip resonator length of a diplexer needs to be accurately tuned to match its prescribed functionality. For this purpose one of the mirrors in the FADIS MkIIa diplexer has been mounted on a motion system, in order to control the mirror to its desired location despite the presence of substantial disturbances. The mechanical properties and control strategy for the mirror motion system have been designed such as to meet the overall system requirements. The performance of the motion system has been experimentally validated in various high power mm-wave tests.
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- 2012
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11. ECRH on ASDEX Upgrade - System Status, Feed-Back Control, Plasma Physics Results
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Flamm J., Vaccaro A., Strauβ D., Scherer Th., Meier A., Stroth U., Kasparek W., Zohm H., Schütz H., Schubert M., Poli E., Münich M., Müller S., Mlynek A., Marascheck M., Monaco F., Leuterer F., Herrmann A., Gianone L., Wagner D., Treutterer W., Sommer F., Reich M., Höhnle H., Bock A., Stober J., Thumm M., Litvak A., Denisov G.G., Chirkov A.V., Tai E.M., Popov L.G., Nichiporenko V.O., Myasnikov V.E., Soluyanova E.A., and Malygin S.A.
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Physics ,QC1-999 - Abstract
The ASDEX Upgrade (AUG) ECRH system now delivers a total of 3.9 MW to the plasma at 140 GHz. Three new units are capable of 2-frequency operation and may heat the plasma alternatively with 2.1 MW at 105 GHz. The system is routinely used with X2, O2, and X3 schemes. For Bt = 3.2 T also an ITER-like O1-scheme can be run using 105 GHz. The new launchers are capable of fast poloidal movements necessary for real-time control of the location of power deposition. Here real-time control of NTMs is summarized, which requires a fast analysis of massive data streams (ECE and Mirnov correlation) and extensive calculations (equilibria, ray-tracing). These were implemented at AUG using a modular concept of standardized real-time diagnostics. The new realtime capabilities have also been used during O2 heating to keep the first reflection of the non-absorbed beam fraction on the holographic reflector tile which ensures a well defined second pass of the beam through the central plasma. Sensors for the beam position are fast thermocouples at the edge of the reflector tile. The enhanced ECRH power was used for several physics studies related to the unique feature of pure electron heating without fueling and without momentum input. As an example the effect of the variation of the heating mix in moderately heated H-modes is demonstrated using the three available heating systems, i.e. ECRH, ICRH and NBI. Keeping the total input power constant, strong effects are seen on the rotation, but none on the pedestal parameters. Also global quantities as the stored energy are hardly modified. Still it is found that the central ion temperature drops as the ECRH fraction exceeds a certain threshold.
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- 2012
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12. Monitoring millimeter wave stray radiation during ECRH operation at ASDEX Upgrade
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Wagner D., Stober J., Schütz H., Schmid-Lorch D., Monaco F., Honecker F., and Schubert M.
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Physics ,QC1-999 - Abstract
Due to imperfection of the single path absorption, ECRH at ASDEX Upgrade (AUG) is always accompanied by stray radiation in the vacuum vessel. New ECRH scenarios with O2 and X3 heating schemes extend the operational space, but they have also the potential to increase the level of stray radiation. There are hazards for invessel components. Damage on electric cables has already been encountered. It is therefore necessary to monitor and control the ECRH with respect to the stray radiation level. At AUG a system of Sniffer antennas equipped with microwave detection diodes is installed. The system is part of the ECRH interlock circuit. We notice, however, that during plasma operation the variations of the Sniffer antenna signal are very large. In laboratory measurements we see variations of up to 20 dB in the directional sensitivity and we conclude that an interference pattern is formed inside the copper sphere of the antenna. When ECRH is in plasma operation at AUG, the plasma is acting as a phase and mode mixer for the millimeter waves and thus the interference pattern inside the sphere changes with the characteristic time of the plasma dynamics. In order to overcome the difficulty of a calibrated measurement of the average stray radiation level, we installed bolometer and pyroelectric detectors, which intrinsically average over interference structures due to their large active area. The bolometer provides a robust calibration but with moderate temporal resolution. The pyroelectric detector provides high sensitivity and a good temporal resolution, but it raises issues of possible signal drifts in long pulses.
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- 2012
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13. A comparison between holographic and near-field ptychographic X-ray tomography for solid oxide cell materials
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Monaco, F., Hubert, M., Da Silva, J.C., Favre-Nicolin, V., Montinaro, D., Cloetens, P., and Laurencin, J.
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- 2022
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14. Fracture properties of porous yttria-stabilized zirconia under micro-compression testing
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Abaza, A., Laurencin, J., Nakajo, A., Hubert, M., David, T., Monaco, F., Lenser, C., and Meille, S.
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- 2022
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15. A Randomized Trial of Intravenous Amino Acids for Kidney Protection.
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Landoni, G., Monaco, F., Ti, L. K., Redaelli, M. Baiardo, Bradic, N., Comis, M., Kotani, Y., Brambillasca, C., Garofalo, E., Scandroglio, A. M., Viscido, C., Paternoster, G., Franco, A., Porta, S., Ferrod, F., Calabrò, M. G., Pisano, A., Vendramin, I., Barucco, G., and Federici, F.
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AMINO acids , *CARDIOPULMONARY bypass , *ACUTE kidney failure , *AMINO group , *PHYSIOLOGIC salines , *CARDIAC surgery - Abstract
Background: Acute kidney injury (AKI) is a serious and common complication of cardiac surgery, for which reduced kidney perfusion is a key contributing factor. Intravenous amino acids increase kidney perfusion and recruit renal functional reserve. However, the efficacy of amino acids in reducing the occurrence of AKI after cardiac surgery is uncertain. Methods: In a multinational, double-blind trial, we randomly assigned adult patients who were scheduled to undergo cardiac surgery with cardiopulmonary bypass to receive an intravenous infusion of either a balanced mixture of amino acids, at a dose of 2 g per kilogram of ideal body weight per day, or placebo (Ringer's solution) for up to 3 days. The primary outcome was the occurrence of AKI, defined according to the Kidney Disease: Improving Global Outcomes creatinine criteria. Secondary outcomes included the severity of AKI, the use and duration of kidney-replacement therapy, and all-cause 30-day mortality. Results: We recruited 3511 patients at 22 centers in three countries and assigned 1759 patients to the amino acid group and 1752 to the placebo group. AKI occurred in 474 patients (26.9%) in the amino acid group and in 555 (31.7%) in the placebo group (relative risk, 0.85; 95% confidence interval [CI], 0.77 to 0.94; P = 0.002). Stage 3 AKI occurred in 29 patients (1.6%) and 52 patients (3.0%), respectively (relative risk, 0.56; 95% CI, 0.35 to 0.87). Kidney-replacement therapy was used in 24 patients (1.4%) in the amino acid group and in 33 patients (1.9%) in the placebo group. There were no substantial differences between the two groups in other secondary outcomes or in adverse events. Conclusions: Among adult patients undergoing cardiac surgery, infusion of amino acids reduced the occurrence of AKI. (Funded by the Italian Ministry of Health; PROTECTION ClinicalTrials.gov number, NCT03709264.). [ABSTRACT FROM AUTHOR]
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- 2024
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16. A multi-user virtual reality experience for space missions
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Mastro, A. Del, Monaco, F., and Benyoucef, Y.
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- 2021
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17. Production and Easy One-Step Purification of Bluetongue Recombinant VP7 from Infected Sf9 Supernatant for an Immunoenzymatic Assay (ELISA)
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Ulisse, S., Iorio, M., Armillotta, G., Laguardia, C., Testa, L., Capista, S., Centorame, P., Traini, S., Serroni, A., Monaco, F., Caporale, M., Mercante, M. T., and Di Ventura, M.
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- 2021
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18. Tick species from Africa by migratory birds: a 3-year study in Italy
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Toma, L., Mancuso, E., d’Alessio, S. G., Menegon, M., Spina, F., Pascucci, I., Monaco, F., Goffredo, M., and Di Luca, M.
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- 2021
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19. A Compact Two-Frequency Notch Filter for Millimeter Wave Plasma Diagnostics
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Wagner, D., Kasparek, W., Leuterer, F., Monaco, F., Ruess, T., Stober, J., and Thumm, M.
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- 2020
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20. Tranexamic acid in coronary artery surgery: One-year results of the Aspirin and Tranexamic Acid for Coronary Artery Surgery (ATACAS) trial
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Myles, Paul, Smith, Julian, Cooper, D. James, Silbert, Brendan, McNeil, John, Marasco, Silvana, Esmore, Donald, Krum, Henry, Tonkin, A., Buxton, B., Heritier, S., Merry, A., Liew, D., McNeil, J., Forbes, A., Cooper, D.J., Wallace, S., Meehan, A., Myles, P., Galagher, W., Farrington, C., Ditoro, A., Wutzlhofer, L., Story, D., Peyton, P., Baulch, S., Sidiropoulos, S., Potgieter, D., Baker, R.A., Pesudovs, B., O'Loughlin J Wells, E., Coutts, P., Bolsin, S., Osborne, C., Ives, K., Smith, J., Hulley, A., Christie-Taylor, G., Painter, T., Lang, S., Mackay, H., Cokis, C., March, S., Bannon, P.G., Wong, C., Turner, L., Scott, D., Silbert, B., Said, S., Corcoran, P., de Prinse, L., Bussières, J.S., Gagné, N., Lamy, A., Semelhago, L., Chan, M.T.V., Underwood, M., Choi, G.S.Y., Fung, B., Landoni, G., Lembo, R., Monaco, F., Simeone, F., Marianello, D., Alvaro, G., De Vuono, G., van Dijk, D., Dieleman, J., Numan, S., McGuinness, S., Parke, R., Raudkivi, P., Gilder, E., Byrne, K., Dunning, J., Termaat, J., Mans, G., Jayarajah, M., Alderton, J., Waugh, D., Platt, M.J., Pai, A., Sevillano, A., Lal, A., Sinclair, C., Kunst, G., Knighton, A., Cubas, G.M., Saravanan, P., Millner, R., Vasudevan, V., Patteril, M., Lopez, E., Basu, R., Lu, J., Myles, Paul S., Smith, Julian A., Kasza, Jessica, Jayarajah, Mohandas, Painter, Thomas, Bussières, Jean S., McGuinness, Shay, Byrne, Kelly, Chan, Matthew T.V., Landoni, Giovanni, Wallace, Sophie, and Forbes, Andrew
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- 2019
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21. Sero-surveillance of emerging viral diseases in camels and cattle in Nouakchott, Mauritania: an abattoir study
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Cosseddu, Gian Mario, Doumbia, B., Scacchia, M., Pinoni, C., Di Provvido, A., Polci, A., Isselmou, K., Di Gennaro, A., Spedicato, M., Carmine, I., Savini, G., Dondona, A. Capobianco, Iapaolo, F., Valleriani, F., El Mamy, Ahmed Bezeid, Barry, Yaya, and Monaco, F.
- Published
- 2021
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22. Argas ticks (Ixodida: Argasidae) on migratory birds from Africa: first record of a genotype close to Argas africolumbae in Italy
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Menegon, M., primary, Casale, F., additional, Mancuso, E., additional, Di Luca, M., additional, Severini, F., additional, Monaco, F., additional, and Toma, L., additional
- Published
- 2023
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23. Experimental validation of a La0.6Sr0.4Co0.2Fe0.8O3-δ electrode model operated in electrolysis mode: Understanding the reaction pathway under anodic polarization
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Monaco, F., Tezyk, V., Siebert, E., Pylypko, S., Morel, B., Vulliet, J., Le Bihan, T., Lefebvre-Joud, F., and Laurencin, J.
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- 2018
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24. Divertikulitis – Bewährtes und Neues im Kontext der aktualisierten S3-Leitlinie
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Rodriguez-Monaco, F.-D., primary, Herter, M., additional, and Dumoulin, F.L., additional
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- 2023
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25. Predicting the Need for Intra-operative Large Volume Blood Transfusions During Thoraco-abdominal Aortic Aneurysm Repair
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Pieri, M., Nardelli, P., De Luca, M., Landoni, G., Frassoni, S., Melissano, G., Zangrillo, A., Chiesa, R., and Monaco, F.
- Published
- 2017
- Full Text
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26. Usutu virus infections in humans: a retrospective analysis in the municipality of Modena, Italy
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Grottola, A., Marcacci, M., Tagliazucchi, S., Gennari, W., Di Gennaro, A., Orsini, M., Monaco, F., Marchegiano, P., Marini, V., Meacci, M., Rumpianesi, F., Lorusso, A., Pecorari, M., and Savini, G.
- Published
- 2017
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27. Correction to: “A Compact Two-Frequency Notch Filter for Millimeter Wave Plasma Diagnostics”
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Wagner, D., Kasparek, W., Leuterer, F., Monaco, F., Ruess, T., Stober, J., and Thumm, M.
- Published
- 2020
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28. Neurodevelopmental outcomes of infants with Vein of Galen aneurismatic malformation
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Pugnaloni, F., primary, Campi, F., additional, Raho, L., additional, Ronci, S., additional, Calì, M., additional, Bersani, I., additional, Savarese, I., additional, Monaco, F., additional, Rechichi, J., additional, Romiti, A., additional, Savignoni, F., additional, De Marchis, C., additional, Braguglia, A., additional, Gandolfo, C., additional, and Dotta, A., additional
- Published
- 2023
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29. Experimental infection of rock pigeons ( Columba livia ) with three West Nile virus lineage 1 strains isolated in Italy between 2009 and 2012
- Author
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SPEDICATO, M., CARMINE, I., BELLACICCO, A. L., MARRUCHELLA, G., MARINI, V., PISCIELLA, M., DI FRANCESCO, G., LORUSSO, A., MONACO, F., and SAVINI, G.
- Published
- 2016
30. Experiments with reduced single pass absorption at ASDEX Upgrade – instrumentation and applications
- Author
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Schubert, M., Stober, J., Herrmann, A., Grigore, E., Kasparek, W., Lechte, C., Monaco, F., Petzold, B., Plaum, B., Poli, E., https://orcid.org/0000-0001-7552-4800, Ruset, C., Vorbrugg, S., Wagner, D., https://orcid.org/0000-0001-8403-6155, and ASDEX Upgrade Team, Max Planck Institute for Plasma Physics, Max Planck Society
- Published
- 2023
31. OC67 STAGED HYBRID EPICARDIAL-ENDOCARDIAL PROCEDURE IN PATIENTS WITH REFRACTORY PERSISTENT/LONG-STANDING PERSISTENT ATRIAL FIBRILLATION AND SEVERE LEFT ATRIAL DILATATION
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Lapenna, E., Cireddu, M., Del Forno, B., Monaco, F., Nisi, T., Bargagna, M., Ajello, S., Gulletta, S., Melisurgo, G., Belluschi, I., D’Angelo, G., Giacomini, A., Pappalardo, F., Alfieri, O., Castiglioni, A., Bella, P. Della, and De Bonis, M.
- Published
- 2018
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32. Self healing of creep-induced damage in Fe-3Au-4W by multiple healing agents studied by synchrotron X-ray nano-tomography
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Fu, Y., primary, Fang, H., additional, Monaco, F., additional, Cloetens, P., additional, Tichelaar, F.D., additional, van Meel, J.G., additional, Brück, E., additional, van der Zwaag, S., additional, and van Dijk, N.H., additional
- Published
- 2022
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- View/download PDF
33. Enabling Scalable SFCs in Kubernetes with eBPF-based Cross-Connections
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Monaco, F, Ognibene, G, Parola, F, and Risso, F
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NFV ,SFC ,eBPF ,Kubernetes - Published
- 2022
34. Compact Multi-Frequency Sub-THz Notch Filters with Rejection within and above the Pass Band
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Wagner, D., primary, Kasparek, W., additional, Leuterer, F., additional, Monaco, F., additional, Ruess, T., additional, Schutz, H., additional, Stober, J., additional, and Thumm, M., additional
- Published
- 2022
- Full Text
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35. SHORT REPORT: West Nile virus lineage 2 in Sardinian wild birds in 2012: a further threat to public health
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SAVINI, G., PUGGIONI, G., DI GENNARO, A., DI FRANCESCO, G., ROCCHIGIANI, A. M., POLCI, A., MARINI, V., PINONI, C., ROLESU, S., MARRUCHELLA, G., LORUSSO, A., and MONACO, F.
- Published
- 2013
36. Status, Operation, and Extension of the ECRH System at ASDEX Upgrade
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Wagner, D., Stober, J., Leuterer, F., Monaco, F., Müller, S., Münich, M., Rapson, C. J., Reich, M., Schubert, M., Schütz, H., Treutterer, W., Zohm, H., Thumm, M., Scherer, T., Meier, A., Gantenbein, G., Jelonnek, J., Kasparek, W., Lechte, C., Plaum, B., Goodman, T., Litvak, A. G., Denisov, G. G., Chirkov, A., Zapevalov, V., Malygin, V., Popov, L. G., Nichiporenko, V. O., Myasnikov, V. E., Tai, E. M., Solyanova, E. A., Malygin, S. A., and ASDEX Upgrade Team
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- 2016
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37. Neutralising antibodies to West Nile virus detected in horses in Windhoek, Namibia
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Molini, U, primary, Franzo, G, additional, Rautenbach, I, additional, Otto, HV, additional, Khaiseb, S, additional, Di Gennaro, A, additional, Ntahonshikira, C, additional, Baines, I, additional, Monaco, F, additional, Savini, G, additional, and D’alterio, N, additional
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- 2022
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38. AB1134 BIBLIOMETRIC NETWORK ANALYSIS ON TOCILIZUMAB TREATMENT FOR COVID-19 PATIENTS
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Cascella, L., primary, Monaco, F., additional, Nocerino, D., additional, Infernuso, A., additional, Cascella, V., additional, Del Prato, F., additional, Cascella, S., additional, and Cascella, M., additional
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- 2022
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39. AB1206 JUVENILE PRIMARY FIBROMYALGIA SYNDROME. RESULTS FROM A VOSVIEWER-BASED BIBLIOMETRIC NETWORK ANALYSIS.
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Cascella, L., primary, Monaco, F., additional, Nocerino, D., additional, Infernuso, A., additional, Cascella, V., additional, Del Prato, F., additional, Cascella, S., additional, Ruggiero, N., additional, and Cascella, M., additional
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- 2022
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40. ASSESSMENT OF SUBMUCOSAL LAYER QUALITY OF COLORECTAL EMR VERSUS ESD SPECIMENS – A PILOT STUDY
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Clees, N., additional, Rodriguez-Monaco, F., additional, Varnai-Händel, A., additional, Hildenbrand, R., additional, Grund, K.E., additional, Metter, K., additional, and Dumoulin, F.L., additional
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- 2022
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41. Schmallenberg virus in Italy: a retrospective survey in Culicoides stored during the bluetongue Italian surveillance program
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Goffredo, M., Monaco, F., Capelli, G., Quaglia, M., Federici, V., Catalani, M., Montarsi, F., Polci, A., Pinoni, C., Calistri, P., and Savini, G.
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- 2013
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42. Progressive right ventricular dysfunction and exercise impairment in patients with heart failure and diabetes mellitus: insights from the T.O.S.CA. Registry
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Salzano, A, D'Assante, R, Iacoviello, M, Triggiani, V, Rengo, G, Cacciatore, F, Maiello, C, Limongelli, G, Masarone, D, Sciacqua, A, Perrone Filardi, P, Mancini, A, Volterrani, M, Vriz, O, Castello, R, Passantino, A, Campo, M, Modesti, Pa, De Giorgi, A, Arcopinto, M, Gargiulo, P, Perticone, M, Colao, A, Milano, S, Garavaglia, A, Napoli, R, Suzuki, T, Bossone, E, Marra, Am, Cittadini, A, Saccà, L, Monti, Mg, Matarazzo, M, Stagnaro, Fm, Piccioli, L, Lombardi, A, Panicara, V, Flora, M, Golia, L, Faga, V, Ruocco, A, Della Polla, D, Franco, R, Schiavo, A, Gigante, A, Spina, E, Sicuranza, M, Monaco, F, Apicella, M, Miele, C, Campanino, Ag, Mazza, L, Abete, R, Farro, A, Luciano, F, Polizzi, R, Ferrillo, G, De Luca, M, Crisci, G, Giardino, F, Barbato, M, Ranieri, B, Ferrara, F, Russo, V, Malinconico, M, Citro, R, Guastalamacchia, E, Leone, M, Giagulli, Va, Amarelli, C, Mattucci, I, Calabrò, P, Calabrò, R, D'Andrea, A, Maddaloni, V, Pacileo, G, Scarafile, R, Belfiore, A, Cimellaro, A, Casaretti, L, Paolillo, S, Favuzzi, Amr, Di Segni, C, Bruno, C, Vergani, E, Massaro, R, Grimaldi, F, Frigo, A, Sorrentino, Mr, Malandrino, D, Manfredini, R, Fabbian, F, Puzzo, A, Ragusa, L, Caliendo, L, Carbone, L, Frigiola, A, Generali, T, Giacomazzi, F, De Vincentiis, C, Ballotta, A, Garofalo, P, Malizia, G, Misiano, G, Israr, Mz, Bernieh, D, Cassambai, S, Yazaki, Y, Heaney, Lm, Eagle, Ka, Ventura, Ho, Bruzzese, D, Salzano, Andrea, D'Assante, Roberta, Iacoviello, Massimo, Triggiani, Vincenzo, Rengo, Giuseppe, Cacciatore, Francesco, Maiello, Ciro, Limongelli, Giuseppe, Masarone, Daniele, Sciacqua, Angela, Filardi, Pasquale Perrone, Mancini, Antonio, Volterrani, Maurizio, Vriz, Olga, Castello, Roberto, Passantino, Andrea, Campo, Michela, Modesti, Pietro A, De Giorgi, Alfredo, Arcopinto, Michele, Gargiulo, Paola, Perticone, Maria, Colao, Annamaria, Milano, Salvatore, Garavaglia, Agnese, Napoli, Raffaele, Suzuki, Toru, Bossone, Eduardo, Marra, Alberto M, Cittadini, Antonio, and Misiano, Gabriella
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Registrie ,Heart Failure ,Endocrinology, Diabetes and Metabolism ,Ventricular Dysfunction, Right ,Diabetes ,Insulins ,Socio-culturale ,Stroke Volume ,Insulin resistance ,Diabete ,Cardiopulmonary exercise test, Chronic heart failure, Diabetes, Insulin resistance, Right ventricle, TOSCA Registry ,Chronic heart failure ,Diabetes Mellitus, Type 2 ,TOSCA Registry ,Exercise Test ,Ventricular Function, Right ,Humans ,Insulin ,Right ventricle ,Registries ,Cardiology and Cardiovascular Medicine ,Cardiopulmonary exercise test ,TOSCA ,Human ,LS4_7 - Abstract
Background Findings from the T.O.S.CA. Registry recently reported that patients with concomitant chronic heart failure (CHF) and impairment of insulin axis (either insulin resistance—IR or diabetes mellitus—T2D) display increased morbidity and mortality. However, little information is available on the relative impact of IR and T2D on cardiac structure and function, cardiopulmonary performance, and their longitudinal changes in CHF. Methods Patients enrolled in the T.O.S.CA. Registry performed echocardiography and cardiopulmonary exercise test at baseline and at a patient-average follow-up of 36 months. Patients were divided into three groups based on the degree of insulin impairment: euglycemic without IR (EU), euglycemic with IR (IR), and T2D. Results Compared with EU and IR, T2D was associated with increased filling pressures (E/e′ratio: 15.9 ± 8.9, 12.0 ± 6.5, and 14.5 ± 8.1 respectively, p 2) in TD2 vs EU and IR patients was recorded (respectively, 15.8 ± 3.8 ml/Kg/min, 18.4 ± 4.3 ml/Kg/min and 16.5 ± 4.3 ml/Kg/min, p 2 in the T2D group (+ 13% increase in RV dimension, − 21% decline in TAPSE/PAPS ratio and − 20% decrease in peak VO2). Conclusion The higher risk of death and CV hospitalizations exhibited by HF-T2D patients in the T.O.S.CA. Registry is associated with progressive RV ventricular dysfunction and exercise impairment when compared to euglycemic CHF patients, supporting the pivotal importance of hyperglycaemia and right chambers in HF prognosis. Trial registration ClinicalTrials.gov identifier: NCT023358017
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- 2022
43. Physicians’ misperceived cardiovascular risk and therapeutic inertia as determinants of low LDL-cholesterol targets achievement in diabetes
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Morieri, M. L., Lamacchia, O., Manzato, E., Giaccari, Andrea, Avogardo, A., Amoresano, L., Angotti, S., Bartone, L., Caraffa, F., Carboni, A., Carro, S., Cervone, S., Clerico, A., Console, I., Conti, D. M., D'Addato, S., De Bellis, Andrea, de Meo, F., di Carlo, A., di Cianni, G., di Giovanni, G., di Lembo, S., Diacono, F., Dolcino, M., Elia, G., Elli, P., Fatone, C., Galli, A., Galluzzo, G., Garzaniti, A., Ghelardi, R., Giacchini, A., Giunta, L., Golia, F., Gregorio, F., Ierna, D., Lampitella, A., Luciano, A., Maffettone, A., Mancini, R., Mangone, I., Mantovani, L. E., Marangoni, A., Marelli, G., Marin, N., Marino, G., Mastromatteo, E., Mazziotti, G., Me, E., Memoli, G., Menicatti, L. S. M., Moffa, Simona, Moise', M., Monaco, F., Morgante, S. N., Pellicano, F., Petraroli, E., Piersanti, D., Pipitone, A., Puglisi, S., Rinaldi, M., Rizzo, M., Rosco, Principia Maria, Scollo, G., Simioni, N., Squadrone, M., Sturniolo, G., Tedeschi, Alessandra, Tizio, B., Ugolotti, D., Valente, L., Vinci, C., Zenoni, L., and Zenti, M. G.
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Inertia ,Real-world ,Adherence ,PCSK9i ,Self-reported survey ,Primary care physicians ,Statins ,Misperceived risk ,Settore MED/13 - ENDOCRINOLOGIA ,Real-world study ,Cardiovascular risk ,Ezetimibe - Published
- 2022
44. West Nile virus Lineage 2 overwintering in Italy
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Mencattelli, G., Rosa', R., Iapaolo, F., Curini, V., Teodori, L., Marini, G., Monaco, F., Savini, G., and Rizzoli, A.
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Settore VET/06 - PARASSITOLOGIA E MALATTIE PARASSITARIE DEGLI ANIMALI - Published
- 2022
45. Efficacy and Safety of Fibrinogen Concentrate in Surgical Patients: A Meta-analysis of Randomized Controlled Trials
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Fominskiy, E., Nepomniashchikh, V. A., Lomivorotov, V. V., Monaco, F., Vitiello, C., Zangrillo, A., and Landoni, G.
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- 2017
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46. Learning to balance a pole on a movable cart through RL: what can be gained using Adaptive NN?
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Borghese, N. A., Biemmi, C., Monaco, F. Lo, Taylor, J. G., editor, Marinaro, Maria, editor, and Tagliaferri, Roberto, editor
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- 1999
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47. Evidence of West Nile virus lineage 2 circulation in Northern Italy
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Savini, G., Capelli, G., Monaco, F., Polci, A., Russo, F., Di Gennaro, A., Marini, V., Teodori, L., Montarsi, F., Pinoni, C., Pisciella, M., Terregino, C., Marangon, S., Capua, I., and Lelli, R.
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- 2012
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48. Progress from ASDEX Upgrade experiments in preparing the physics basis of ITER operation and DEMO scenario development
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Stroth, U., primary, Aguiam, D., additional, Alessi, E., additional, Angioni, C., additional, Arden, N., additional, Parra, R. Arredondo, additional, Artigues, V., additional, Asunta, O., additional, Balden, M., additional, Bandaru, V., additional, Banon-Navarro, A., additional, Behler, K., additional, Bergmann, A., additional, Bergmann, M., additional, Bernardo, J., additional, Bernert, M., additional, Biancalani, A., additional, Bielajew, R., additional, Bilato, R., additional, Birkenmeier, G., additional, Blanken, T., additional, Bobkov, V., additional, Bock, A., additional, Body, T., additional, Bolzonella, T., additional, Bonanomi, N., additional, Bortolon, A., additional, Böswirth, B., additional, Bottereau, C., additional, Bottino, A., additional, van den Brand, H., additional, Brenzke, M., additional, Brezinsek, S., additional, Brida, D., additional, Brochard, F., additional, Bruhn, C., additional, Buchanan, J., additional, Buhler, A., additional, Burckhart, A., additional, Camenen, Y., additional, Cannas, B., additional, Megias, P. Cano, additional, Carlton, D., additional, Carr, M., additional, Carvalho, P., additional, Castaldo, C., additional, Cavedon, M., additional, Cazzaniga, C., additional, Challis, C., additional, Chankin, A., additional, Cianfarani, C., additional, Clairet, F., additional, Coda, S., additional, Coelho, R., additional, Coenen, J.W., additional, Colas, L., additional, Conway, G., additional, Costea, S., additional, Coster, D., additional, Cote, T., additional, Creely, A.J., additional, Croci, G., additional, Zabala, D.J. Cruz, additional, Cseh, G., additional, Czarnecka, A., additional, Cziegler, I., additional, D’Arcangelo, O., additional, Molin, A. Dal, additional, David, P., additional, Day, C., additional, de Baar, M., additional, de Marné, P., additional, Delogu, R., additional, Denk, S., additional, Denner, P., additional, Di Siena, A., additional, Palacios Durán, J.J. Dominguez, additional, Dunai, D., additional, Drenik, A., additional, Dreval, M., additional, Drube, R., additional, Dunne, M., additional, Duval, B.P., additional, Dux, R., additional, Eich, T., additional, Elgeti, S., additional, Encheva, A., additional, Engelhardt, K., additional, Erdös, B., additional, Erofeev, I., additional, Esposito, B., additional, Fable, E., additional, Faitsch, M., additional, Fantz, U., additional, Farnik, M., additional, Faugel, H., additional, Felici, F., additional, Ficker, O., additional, Fietz, S., additional, Figueredo, A., additional, Fischer, R., additional, Ford, O., additional, Frassinetti, L., additional, Fröschle, M., additional, Fuchert, G., additional, Fuchs, J.C., additional, Fünfgelder, H., additional, Futatani, S., additional, Galazka, K., additional, Galdon-Quiroga, J., additional, Escolà, D. Gallart, additional, Gallo, A., additional, Gao, Y., additional, Garavaglia, S., additional, Muñoz, M. Garcia, additional, Geiger, B., additional, Giannone, L., additional, Gibson, S., additional, Gil, L., additional, Giovannozzi, E., additional, Glöggler, S., additional, Gobbin, M., additional, Martin, J. Gonzalez, additional, Goodman, T., additional, Gorini, G., additional, Görler, T., additional, Gradic, D., additional, Granucci, G., additional, Gräter, A., additional, Greuner, H., additional, Griener, M., additional, Groth, M., additional, Gude, A., additional, Guimarais, L., additional, Günter, S., additional, Haas, G., additional, Hakola, A.H., additional, Ham, C., additional, Happel, T., additional, den Harder, N., additional, Harrer, G., additional, Harrison, J., additional, Hauer, V., additional, Hayward-Schneider, T., additional, Heinemann, B., additional, Hellsten, T., additional, Henderson, S., additional, Hennequin, P., additional, Herrmann, A., additional, Heyn, E., additional, Hitzler, F., additional, Hobirk, J., additional, Höfler, K., additional, Holm, J.H., additional, Hölzl, M., additional, Hopf, C., additional, Horvath, L., additional, Höschen, T., additional, Houben, A., additional, Hubbard, A., additional, Huber, A., additional, Hunger, K., additional, Igochine, V., additional, Iliasova, M., additional, Ilkei, T., additional, Björk, K. Insulander, additional, Ionita-Schrittwieser, C., additional, Ivanova-Stanik, I., additional, Jacob, W., additional, Jaksic, N., additional, Janky, F., additional, Jansen van Vuuren, A., additional, Jardin, A., additional, Jaulmes, F., additional, Jenko, F., additional, Jensen, T., additional, Joffrin, E., additional, Kallenbach, A., additional, Kálvin, S., additional, Kantor, M., additional, Kappatou, A., additional, Kardaun, O., additional, Karhunen, J., additional, Käsemann, C.-P., additional, Kasilov, S., additional, Kendl, A., additional, Kernbichler, W., additional, Khilkevitch, E., additional, Kirk, A., additional, Hansen, S. Kjer, additional, Klevarova, V., additional, Kocsis, G., additional, Koleva, M., additional, Komm, M., additional, Kong, M., additional, Krämer-Flecken, A., additional, Krieger, K., additional, Krivska, A., additional, Kudlacek, O., additional, Kurki-Suonio, T., additional, Kurzan, B., additional, Labit, B., additional, Lackner, K., additional, Laggner, F., additional, Lahtinen, A., additional, Lang, P.T., additional, Lauber, P., additional, Leuthold, N., additional, Li, L., additional, Likonen, J., additional, Linder, O., additional, Lipschultz, B., additional, Liu, Y., additional, Lohs, A., additional, Lu, Z., additional, Luda di Cortemiglia, T., additional, Luhmann, N.C., additional, Lunt, T., additional, Lyssoivan, A., additional, Maceina, T., additional, Madsen, J., additional, Magnanimo, A., additional, Maier, H., additional, Mailloux, J., additional, Maingi, R., additional, Maj, O., additional, Maljaars, E., additional, Manas, P., additional, Mancini, A., additional, Manhard, A., additional, Mantica, P., additional, Mantsinen, M., additional, Manz, P., additional, Maraschek, M., additional, Marchetto, C., additional, Marrelli, L., additional, Martin, P., additional, Martitsch, A., additional, Matos, F., additional, Mayer, M., additional, Mayoral, M.-L., additional, Mazon, D., additional, McCarthy, P.J., additional, McDermott, R., additional, Merkel, R., additional, Merle, A., additional, Meshcheriakov, D., additional, Meyer, H., additional, Milanesio, D., additional, Cabrera, P. Molina, additional, Monaco, F., additional, Muraca, M., additional, Nabais, F., additional, Naulin, V., additional, Nazikian, R., additional, Nem, R.D., additional, Nemes-Czopf, A., additional, Neu, G., additional, Neu, R., additional, Nielsen, A.H., additional, Nielsen, S.K., additional, Nishizawa, T., additional, Nocente, M., additional, Noterdaeme, J.-M., additional, Novikau, I., additional, Nowak, S., additional, Oberkofler, M., additional, Ochoukov, R., additional, Olsen, J., additional, Orain, F., additional, Palermo, F., additional, Pan, O., additional, Papp, G., additional, Perez, I. Paradela, additional, Pau, A., additional, Pautasso, G., additional, Paz-Soldan, C., additional, Petersson, P., additional, Piovesan, P., additional, Piron, C., additional, Plank, U., additional, Plaum, B., additional, Plöck, B., additional, Plyusnin, V., additional, Pokol, G., additional, Poli, E., additional, Porte, L., additional, Pütterich, T., additional, Ramisch, M., additional, Rasmussen, J., additional, Ratta, G., additional, Ratynskaia, S., additional, Raupp, G., additional, Réfy, D., additional, Reich, M., additional, Reimold, F., additional, Reiser, D., additional, Reisner, M., additional, Reiter, D., additional, Ribeiro, T., additional, Riedl, R., additional, Riesch, J., additional, Rittich, D., additional, Rodriguez, J.F. Rivero, additional, Rocchi, G., additional, Rodriguez-Fernandez, P., additional, Rodriguez-Ramos, M., additional, Rohde, V., additional, Ronchi, G., additional, Ross, A., additional, Rott, M., additional, Rubel, M., additional, Ryan, D.A., additional, Ryter, F., additional, Saarelma, S., additional, Salewski, M., additional, Salmi, A., additional, Samoylov, O., additional, Sanchez, L. Sanchis, additional, Santos, J., additional, Sauter, O., additional, Schall, G., additional, Schlüter, K., additional, Schmid, K., additional, Schmitz, O., additional, Schneider, P.A., additional, Schrittwieser, R., additional, Schubert, M., additional, Schuster, C., additional, Schwarz-Selinger, T., additional, Schweinzer, J., additional, Seliunin, E., additional, Shabbir, A., additional, Shalpegin, A., additional, Sharapov, S., additional, Sheikh, U., additional, Shevelev, A., additional, Sias, G., additional, Siccinio, M., additional, Sieglin, B., additional, Sigalov, A., additional, Silva, A., additional, Silva, C., additional, Silvagni, D., additional, Simpson, J., additional, Sipilä, S., additional, Smigelskis, E., additional, Snicker, A., additional, Solano, E., additional, Sommariva, C., additional, Sozzi, C., additional, Spizzo, G., additional, Spolaore, M., additional, Stegmeir, A., additional, Stejner, M., additional, Stober, J., additional, Strumberge, E., additional, Lopez, G. Suarez, additional, Sun, H.-J., additional, Suttrop, W., additional, Sytova, E., additional, Szepesi, T., additional, Tál, B., additional, Tala, T., additional, Tardini, G., additional, Tardocchi, M., additional, Terranova, D., additional, Teschke, M., additional, Thorén, E., additional, Tierens, W., additional, Told, D., additional, Treutterer, W., additional, Trevisan, G., additional, Trier, E., additional, Tripský, M., additional, Usoltceva, M., additional, Valisa, M., additional, Valovic, M., additional, van Zeeland, M., additional, Vannini, F., additional, Vanovac, B., additional, Varela, P., additional, Varoutis, S., additional, Vianello, N., additional, Vicente, J., additional, Verdoolaege, G., additional, Vierle, T., additional, Viezzer, E., additional, Voitsekhovitch, I., additional, von Toussaint, U., additional, Wagner, D., additional, Wang, X., additional, Weiland, M., additional, White, A.E., additional, Willensdorfer, M., additional, Wiringer, B., additional, Wischmeier, M., additional, Wolf, R., additional, Wolfrum, E., additional, Yang, Q., additional, Yu, Q., additional, Zagórski, R., additional, Zammuto, I., additional, Zehetbauer, T., additional, Zhang, W., additional, Zholobenko, W., additional, Zilker, M., additional, Zito, A., additional, Zohm, H., additional, Zoletnik, S., additional, and EUROfusion MST1 Team, the, additional
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- 2022
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49. Multiple hormonal and metabolic deficiency syndrome predicts outcome in heart failure: the T.O.S.CA. Registry
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Cittadini A., Salzano A., Iacoviello M., Triggiani V., Rengo G., Cacciatore F., Maiello C., Limongelli G., Masarone D., Perticone F., Cimellaro A., Filardi P. P., Paolillo S., Mancini A., Volterrani M., Vriz O., Castello R., Passantino A., Campo M., Modesti P. A., de Giorgi A., Monte I. P., Puzzo A., Ballotta A., D'Assante R., Arcopinto M., Gargiulo P., Sciacqua A., Bruzzese D., Colao A., Napoli R., Suzuki T., Eagle K. A., Ventura H. O., Marra A. M., Bossone E., Sacca L., Monti M. G., Matarazzo M., Stagnaro F. M., Piccioli L., Lombardi A., Panicara V., Flora M., Golia L., Faga V., Ruocco A., della Polla D., Franco R., Schiavo A., Gigante A., Spina E., Sicuranza M., Monaco F., Apicella M., Miele C., Campanino A. G., Mazza L., Abete R., Farro A., Luciano F., Polizzi R., Ferrillo G., de Luca M., Crisci G., Giardino F., Barbato M., Ranieri B., Ferrara F., Russo V., Malinconico M., Citro R., Guastalamacchia E., Leone M., Giagulli V. A., Amarelli C., Mattucci I., Calabro P., Calabro R., D'Andrea A., Maddaloni V., Pacileo G., Scarafile R., Belfiore A., Casaretti L., Favuzzi A. M. R., Di Segni C., Bruno C., Vergani E., Massaro R., Grimaldi F., Frigo A., Campo M. R., Sorrentino M. R., Malandrino D., Manfredini R., Fabbian F., Ragusa L., Caliendo L., Carbone L., Frigiola A., Generali T., Giacomazzi F., de Vincentiis C., Garofalo P., Malizia G., Milano S., Misiano G., Israr M. Z., Bernieh D., Cassambai S., Yazaki Y., Heaney L. M., Cittadini, Antonio, Salzano, Andrea, Iacoviello, Massimo, Triggiani, Vincenzo, Rengo, Giuseppe, Cacciatore, Francesco, Maiello, Ciro, Limongelli, Giuseppe, Masarone, Daniele, Perticone, Francesco, Cimellaro, Antonio, Perrone Filardi, Pasquale, Paolillo, Stefania, Mancini, Antonio, Volterrani, Maurizio, Vriz, Olga, Castello, Roberto, Passantino, Andrea, Campo, Michela, Modesti, Pietro A, De Giorgi, Alfredo, Monte, Ines P, Puzzo, Alfonso, Ballotta, Andrea, D'Assante, Roberta, Arcopinto, Michele, Gargiulo, Paola, Sciacqua, Angela, Bruzzese, Dario, Colao, Annamaria, Napoli, Raffaele, Suzuki, Toru, Eagle, Kim A, Ventura, Hector O, Marra, Alberto M, Bossone, Eduardo, Cittadini, A., Salzano, A., Iacoviello, M., Triggiani, V., Rengo, G., Cacciatore, F., Maiello, C., Limongelli, G., Masarone, D., Perticone, F., Cimellaro, A., Filardi, P. P., Paolillo, S., Mancini, A., Volterrani, M., Vriz, O., Castello, R., Passantino, A., Campo, M., Modesti, P. A., de Giorgi, A., Monte, I. P., Puzzo, A., Ballotta, A., D'Assante, R., Arcopinto, M., Gargiulo, P., Sciacqua, A., Bruzzese, D., Colao, A., Napoli, R., Suzuki, T., Eagle, K. A., Ventura, H. O., Marra, A. M., Bossone, E., Sacca, L., Monti, M. G., Matarazzo, M., Stagnaro, F. M., Piccioli, L., Lombardi, A., Panicara, V., Flora, M., Golia, L., Faga, V., Ruocco, A., della Polla, D., Franco, R., Schiavo, A., Gigante, A., Spina, E., Sicuranza, M., Monaco, F., Apicella, M., Miele, C., Campanino, A. G., Mazza, L., Abete, R., Farro, A., Luciano, F., Polizzi, R., Ferrillo, G., de Luca, M., Crisci, G., Giardino, F., Barbato, M., Ranieri, B., Ferrara, F., Russo, V., Malinconico, M., Citro, R., Guastalamacchia, E., Leone, M., Giagulli, V. A., Amarelli, C., Mattucci, I., Calabro, P., Calabro, R., D'Andrea, A., Maddaloni, V., Pacileo, G., Scarafile, R., Belfiore, A., Casaretti, L., Favuzzi, A. M. R., Di Segni, C., Bruno, C., Vergani, E., Massaro, R., Grimaldi, F., Frigo, A., Campo, M. R., Sorrentino, M. R., Malandrino, D., Manfredini, R., Fabbian, F., Ragusa, L., Caliendo, L., Carbone, L., Frigiola, A., Generali, T., Giacomazzi, F., de Vincentiis, C., Garofalo, P., Malizia, G., Milano, S., Misiano, G., Israr, M. Z., Bernieh, D., Cassambai, S., Yazaki, Y., and Heaney, L. M.
- Subjects
medicine.medical_specialty ,Multiple hormonal and metabolic deficiency syndrome ,Epidemiology ,Prognosi ,Anabolic deficiency ,Socio-culturale ,Heart failure ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,03 medical and health sciences ,0302 clinical medicine ,Insulin resistance ,Diabetes mellitus ,Internal medicine ,Multiple hormonal ,medicine ,Clinical endpoint ,Humans ,030212 general & internal medicine ,Prospective Studies ,Registries ,TOSCA ,LS4_7 ,Ejection fraction ,business.industry ,Hazard ratio ,Metabolic deficiency syndrome ,Heart failure • Anabolic deficiency • Multiple hormonal and metabolic deficiency syndrome • Hormones • Prognosis • TOSCA ,Stroke Volume ,medicine.disease ,Prognosis ,Hormone ,Confidence interval ,Heart failure, Anabolic deficiency, Multiple hormonal and metabolic deficiency syndrome, Hormones, Prognosis, TOSCA ,Hormones ,Hospitalization ,Observational study ,Cardiology and Cardiovascular Medicine ,business - Abstract
Aims Recent evidence supports the occurrence of multiple hormonal and metabolic deficiency syndrome (MHDS) in chronic heart failure (CHF). However, no large observational study has unequivocally demonstrated its impact on CHF progression and outcome. The T.O.S.CA. (Trattamento Ormonale nello Scompenso CArdiaco; Hormone Treatment in Heart Failure) Registry has been specifically designed to test the hypothesis that MHDS affects morbidity and mortality in CHF patients. Methods and Results The T.O.S.CA. Registry is a prospective, multicentre, observational study involving 19 Italian centres. Thyroid hormones, insulin-like growth factor-1, total testosterone, dehydropianoandrosterone sulfate, insulin resistance, and the presence of diabetes were evaluated. A MHDS was defined as the presence of ≥2 hormone deficiencies (HDs). Primary endpoint was a composite of all-cause mortality and cardiovascular hospitalizations. Four hundred and eighty heart failure patients with ejection fraction ≤45% were enrolled. MHDS or diabetes was diagnosed in 372 patients (77.5%). A total of 271 events (97 deaths and 174 cardiovascular hospitalizations) were recorded, 41% in NO-MHDS and 62% in MHDS (P Conclusion MHDS is common in CHF and independently associated with increased all-cause mortality and cardiovascular hospitalization, representing a promising therapeutic target. Trial registration ClinicalTrials.gov identifier: NCT023358017
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- 2021
50. Propensity Score and Desirability of Outcome Ranking Analysis of Ertapenem for Treatment of Nonsevere Bacteremic Urinary Tract Infections Due to Extended-Spectrum-Beta-Lactamase-Producing Enterobacterales in Kidney Transplant Recipients
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Gutierrez-Gutierrez, B., Perez-Nadales, E., Perez-Galera, S., Fernandez-Ruiz, M., Carratala, J., Oriol, I., Cordero, E., Lepe, J. A., Tan, B. H., Corbella, L., Paul, M., Natera, A. M., David, M. D., Montejo, M., Iyer, R. N., Pierrotti, L. C., Merino, E., Steinke, S. M., Rana, M. M., Munoz, P., Mularoni, A., van Delden, C., Grossi, P. A., Seminari, E. M., Gunseren, F., Lease, E. D., Roilides, E., Fortun, J., Arslan, H., Coussement, J., Tufan, Z. K., Pilmis, B., Rizzi, M., Loeches, B., Eriksson, B. M., Abdala, E., Soldani, F., Lowman, W., Clemente, W. T., Bodro, M., Farinas, M. C., Kazak, E., Martinez-Martinez, L., Aguado, J. M., Torre-Cisneros, J., Pascual, A., Rodriguez-Bano, J., Sabe, N., Camoez, M., Martin-Gandul, C., Bernal, G., Kee, T. Y. S., Lopez-Medrano, F., Juan, R. S., Koppel, F., Bar-Sinai, N., Caston, J. J., Cano, A., Gracia-Ahufinger, I., Rodriguez, R., Lopez-Soria, L., Azurmendi, M., Pinheiro, M., Freire, M., Banks, I., Lopes, F., David-Neto, E., Balibrea, N., Franco, A., Avery, R., Ostrander, D., Minero, M. V., Carrillo, C. S., Rodriguez-Ferrero, M. L., Monaco, F., Campanella, M., Mueller, N. J., Manuel, O., Khanna, N., Rovelli, C., Balsamo, M. L., Colombo, A., Leoni, C., Pyrpasopoulou, A., Mouloudi, E., Iosifidis, E., Martin-Davila, P., Gioia, F., Escudero, R., Demirkaya, M. H., Dewispelaere, L., Kalem, A. K., Hasanoglu, I., Guner, R., Lortholary, O., Scemla, A., Calvi, E. G., Gervasi, E., Binda, F., Oliva, M. L., Dimopoulos, N., Magalhaes, M. R., Song, A. T. W., D'Albuquerque, L. A. C., Chiesi, S., Salerno, N. D., Mourao, P. H. O., Moreno, A., Linares, L., Almela, M., Rico, C. G., Rodrigo, E., Martinez, M. F., Falcone, M., Tumbarello, M., Strabelli, T. M. V., Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Red Española de Investigación en Patología Infecciosa, European Commission, Sociedad Andaluza de Trasplante de Órganos y Tejidos, and Ministerio de Ciencia e Innovación (España)
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Ertapenem ,medicine.medical_specialty ,Urinary system ,UTI ,Bacteremia ,Bloodstream infection ,BSI ,Logistic regression ,Extended-spectrum-b-lactamase-producing Enterobacterales ,Meropenem ,beta-Lactamases ,Cohort Studies ,chemistry.chemical_compound ,Internal medicine ,polycyclic compounds ,medicine ,Humans ,Pharmacology (medical) ,Propensity Score ,Kidney transplant ,Retrospective Studies ,Pharmacology ,Urinary tract infection ,business.industry ,ESBL-E ,Anti-Bacterial Agents ,Kidney Transplantation ,Urinary Tract Infections ,bacterial infections and mycoses ,medicine.disease ,Infectious Diseases ,chemistry ,Propensity score matching ,Cohort ,business ,medicine.drug ,Cohort study - Abstract
REIPI/ESGICH/ESGBIS/INCREMENT-SOT Group., There are scarce data on the efficacy of ertapenem in the treatment of bacteremia due to extended-spectrum-beta-lactamase (ESBL)-producing Enterobacterales (ESBL-E) in kidney transplant (KT) recipients. We evaluated the association between treatment with ertapenem or meropenem and clinical cure in KT recipients with nonsevere bacteremic urinary tract infections (B-UTI) caused by ESBL-E. We performed a registered, retrospective, international (29 centers in 14 countries) cohort study (INCREMENT-SOT, NCT02852902). The association between targeted therapy with ertapenem versus meropenem and clinical cure at day 14 (the principal outcome) was studied by logistic regression. Propensity score matching and desirability of outcome ranking (DOOR) analyses were also performed. A total of 201 patients were included; only 1 patient (treated with meropenem) in the cohort died. Clinical cure at day 14 was reached in 45/100 (45%) and 51/101 (50.5%) of patients treated with ertapenem and meropenem, respectively (adjusted OR 1.29; 95% CI 0.51 to 3.22; P = 0.76); the propensity score-matched cohort included 55 pairs (adjusted OR for clinical cure at day 14, 1.18; 95% CI 0.43 to 3.29; P = 0.74). In this cohort, the proportion of cases treated with ertapenem with better DOOR than with meropenem was 49.7% (95% CI, 40.4 to 59.1%) when hospital stay was considered. It ranged from 59 to 67% in different scenarios of a modified (weights-based) DOOR sensitivity analysis when potential ecological advantage or cost was considered in addition to outcome. In conclusion, targeted therapy with ertapenem appears as effective as meropenem to treat nonsevere B-UTI due to ESBL-E in KT recipients and may have some advantages., This work was supported by Plan Nacional de I+D+i 2013‐2016 and Instituto de Salud Carlos III (ISCIII), Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0001, RD16/0016/0002, RD16/0016/0008; RD16/0016/00010) and was cofinanced by the European Development Regional Fund “A way to achieve Europe,” Operative program Intelligent Growth 2014‐2020; ESCMID Study Group for Infections in Compromised Hosts (ESGICH grant to J.M.A.); Sociedad Andaluza de Trasplante de Órgano Sólido (SATOT grant to L.M.-M.); ESCMID Study Group for Bloodstream Infections and Sepsis (ESGBIS); and ESCMID Study Group for Antimicrobial Resistance Surveillance (ESGARS). B.G.-G. (PI 18/01849) and E.P.-N. (PI 16/01631) have received research funds from the Spanish Ministry of Science and Innovation, ISCIII; M.F.-R. holds a research contract “Miguel Servet” (CP 18/00073) from the Spanish Ministry of Science and Innovation, ISCIII.
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- 2021
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