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444 results on '"Monacelli, Fiammetta"'

2. Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer’s models

Author

Rangan, Priya, Lobo, Fleur, Parrella, Edoardo, Rochette, Nicolas, Morselli, Marco, Stephen, Terri-Leigh, Cremonini, Anna Laura, Tagliafico, Luca, Persia, Angelica, Caffa, Irene, Monacelli, Fiammetta, Odetti, Patrizio, Bonfiglio, Tommaso, Nencioni, Alessio, Pigliautile, Martina, Boccardi, Virginia, Mecocci, Patrizia, Pike, Christian J, Cohen, Pinchas, LaDu, Mary Jo, Pellegrini, Matteo, Xia, Kyle, Tran, Katelynn, Ann, Brandon, Chowdhury, Dolly, and Longo, Valter D

Subjects
Biochemistry and Cell Biology, Biological Sciences, Neurosciences, Brain Disorders, Alzheimer's Disease, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Nutrition, Acquired Cognitive Impairment, Neurodegenerative, Aging, Stem Cell Research, Dementia, Stem Cell Research - Nonembryonic - Non-Human, Neurological, Alzheimer Disease, Amyloid beta-Peptides, Animals, Cognitive Dysfunction, Disease Models, Animal, Fasting, Mice, Mice, Transgenic, NADPH Oxidases, Neuroinflammatory Diseases, Superoxides, tau Proteins, Alzheimer’s disease, CP: Metabolism, CP: Neuroscience, NADPH oxidase, amyloid beta, fasting, fasting-mimicking diet, hyperphosphorylated tau, microglia, neuroinflammation, protein restriction, superoxide, Medical Physiology, Biological sciences
Abstract

The effects of fasting-mimicking diet (FMD) cycles in reducing many aging and disease risk factors indicate it could affect Alzheimer's disease (AD). Here, we show that FMD cycles reduce cognitive decline and AD pathology in E4FAD and 3xTg AD mouse models, with effects superior to those caused by protein restriction cycles. In 3xTg mice, long-term FMD cycles reduce hippocampal Aβ load and hyperphosphorylated tau, enhance genesis of neural stem cells, decrease microglia number, and reduce expression of neuroinflammatory genes, including superoxide-generating NADPH oxidase (Nox2). 3xTg mice lacking Nox2 or mice treated with the NADPH oxidase inhibitor apocynin also display improved cognition and reduced microglia activation compared with controls. Clinical data indicate that FMD cycles are feasible and generally safe in a small group of AD patients. These results indicate that FMD cycles delay cognitive decline in AD models in part by reducing neuroinflammation and/or superoxide production in the brain.

Published
2022

5. Identification of new FK866 analogues with potent anticancer activity against pancreatic cancer

Author

Bai, Jian-Fei, Majjigapu, Somi Reddy, Sordat, Bernard, Poty, Sophie, Vogel, Pierre, Elías-Rodríguez, Pilar, Moreno-Vargas, Antonio J., Carmona, Ana T., Caffa, Irene, Ghanem, Moustafa, Khalifa, Amr, Monacelli, Fiammetta, Cea, Michele, Robina, Inmaculada, Gajate, Consuelo, Mollinedo, Faustino, Bellotti, Axel, Nahimana, Aimable, Duchosal, Michel, and Nencioni, Alessio

Published
2022
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6. Tipping the Balance Between Cognitive Reserve, Frailty, and Dementia in the Very Old?

Author

Ottaviani, Silvia, Tagliafico, Luca, Muzyka, Mariya, Page, Elena, Ottaviani, Ennio, Ponzano, Marta, Signori, Alessio, Nencioni, Alessio, and Monacelli, Fiammetta

Subjects
AMNESTIC mild cognitive impairment, ALZHEIMER'S disease, OLDER people, OLDER patients, GERIATRIC assessment
Abstract

Background: As the population ages, the concept of frailty becomes increasingly relevant and may be considered a precursor between aging and the development of dementia in later life. Similarly, the construct of cognitive reserve (CR) is an accepted model of cognitive resilience that may account for individual differences in trajectories of brain aging, mitigating the clinical expression of dementia. Objective: We aim to estimate the role of CR and frailty in moderating the prediction of dementia in the population aged over 80 who are attending an Italian outpatient memory clinic. Methods: Comprehensive Geriatric Assessment, Clinical Frailty Scale (CFS) to screen for frailty, and Cognitive Reserve Index questionnaire (CRIq) to evaluate CR, were used to assess patients systematically. We performed multivariate logistic regression to assess associations with dementia. Model performance and interaction between frailty and cognitive reserve were then evaluated. Results: 166 patients were consecutively enrolled (mean age was 85.7 years old, females composed 68%); 25% had a diagnosis of amnestic mild cognitive impairment, and 75% had a diagnosis of dementia. Multivariate regression analysis showed that CRIq and CFS were the main clinical assessment tools associated with the presence of dementia, even after collinearity adjustment. No significant interaction of CFS*CRIq was found. Conclusions: To our knowledge, this is the first study to investigate the association between CR, frailty, dementia, and their related interacting terms in a real-world population of very old patients. Our findings may suggest that both CR and frailty shape an individual's resilience throughout their lifetime. This may potentially counteract the effects of brain neuropathology, in line with the hypothesis that meaningful associations exist between CR, frailty, and cognition in later life. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Limbic Network Derangement Mediates Unawareness of Apathy in Mild Cognitive Impairment due to Alzheimer's Disease: Clues from [18F]FDG PET Voxel-Wise Analysis.

Author

Kreshpa, Wendy, Raffa, Stefano, Girtler, Nicola, Brugnolo, Andrea, Mattioli, Pietro, Orso, Beatrice, Calizzano, Francesco, Arnaldi, Dario, Peira, Enrico, Chincarini, Andrea, Tagliafico, Luca, Monacelli, Fiammetta, Calcagno, Pietro, Serafini, Gianluca, Gotta, Fabio, Mandich, Paola, Pretta, Stefano, Del Sette, Massimo, Sofia, Luca, and Sambuceti, Gianmario

Subjects
MILD cognitive impairment, ALZHEIMER'S disease, CINGULATE cortex, BRAIN metabolism, CAREGIVERS
Abstract

Background: Discrepancy between caregiver and patient assessments of apathy in mild cognitive impairment (MCI) is considered an index of apathy unawareness, independently predicting progression to AD dementia. However, its neural underpinning are uninvestigated. Objective: To explore the [18F]FDG PET-based metabolic correlates of apathy unawareness measured through the discrepancy between caregiver and patient self-report, in patients diagnosed with MCI. Methods: We retrospectively studied 28 patients with an intermediate or high likelihood of MCI-AD, progressed to dementia over an average of two years, whose degree of apathy was evaluated by means of the Apathy Evaluation Scale (AES) for both patients (PT-AES) and caregivers (CG-AES). Voxel-based analysis at baseline was used to obtain distinct volumes of interest (VOIs) correlated with PT-AES, CG-AES, or their absolute difference (DISCR-AES). The resulting DISCR-AES VOI count densities were used as covariates in an inter-regional correlation analysis (IRCA) in MCI-AD patients and a group of matched healthy controls (HC). Results: DISCR-AES negatively correlated with metabolism in bilateral parahippocampal gyrus, posterior cingulate cortex, and thalamus, PT-AES score with frontal and anterior cingulate areas, while there was no significant correlation between CG-AES and brain metabolism. IRCA revealed that MCI-AD patients exhibited reduced metabolic/functional correlations of the DISCR-AES VOI with the right cingulate gyrus and its anterior projections compared to HC. Conclusions: Apathy unawareness entails early disruption of the limbic circuitry rather than the classical frontal-subcortical pathways typically associated with apathy. This reaffirms apathy unawareness as an early and independent measure in MCI-AD, marked by distinct pathophysiological alterations. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Multidimensional-Based Prediction of Pressure Ulcers Development and Severity in Hospitalized Frail Oldest Old: A Retrospective Study.

Author

Ottaviani, Silvia, Rondanina, Eleonora, Arnone, Floriana, Brucato, Virna, Campigli, Roberto, Bona, Massimo Della, Tagliafico, Luca, Ottaviani, Ennio, Nencioni, Alessio, and Monacelli, Fiammetta

Subjects
FRAIL elderly, GERIATRIC care units, NUTRITIONAL assessment, OLDER people, PHYSICAL mobility
Abstract

Purpose: In recent times, growing uncertainty has emerged regarding the effectiveness of standard pressure ulcer (PU) risk assessment tools, which are suspected to be no better than clinical judgment, especially in the frail and comorbid elderly population. This study aimed to identify the primary clinical predictive variables for PU development and severity in hospitalized older adults, utilizing a multidimensional frailty assessment, and compare them with the Braden scale. Patients and methods: The population consisted of 316 patients, admitted to the Geriatric Unit and Transitional Care of San Bartolomeo Hospital in Sarzana (Italy) during the period 21/02/22-01/07/22. The collected information included both anamnestic and laboratory data. A comprehensive geriatric assessment was performed, including also anthropometric and physical performance measurements. Multivariate logistic analysis was used, both in a binary classification test and in the subsequent ordinal classification test of severity levels. The final performance of the model was assessed by ROC curve estimation and AUC comparison with the Braden scale. Results: Within the population, 152 subjects (48%) developed PU at different levels of severity. The results showed that age, Braden scale (subscales of mobility and friction/shear), Barthel scale, Mini Nutritional Assessment, hemoglobin, and albumin are predictors associated with the development of PU (AUC 85%). The result is an improvement over the use of the Braden scale alone (AUC 75%). Regarding the identification of predictive factors for PU severity, 4AT also emerges as potentially relevant. Conclusion: Assessing the subject's nutritional status, physical performance, and functional autonomies enables the effective integration of the Braden scale in identifying patients most susceptible to developing PU. Our findings support the integration of a comprehensive set of methodologically robust frailty determinants into traditional risk assessment tools. This integration reflects the mutual interplay between patients' frailty, skin frailty, and PU development in very old hospitalized patients. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Bone loss and osteosarcopenia induced by aromatase inhibitor treatment in elderly patients with breast cancer: the role of intervention with inhibitors of RANK/RANKL system

Author

casabella, andrea, primary, Paladin, Francesca, additional, ottaviani, silvia, additional, Marelli, Cristina, additional, Ponzano, Marta, additional, Signori, Alessio, additional, Paolino, Sabrina, additional, Cutolo, Maurizio, additional, Molfetta, Luigi, additional, Nencioni, Alessio, additional, Murdaca, Giuseppe, additional, and Monacelli, Fiammetta, additional

Published
2024
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15. Clinical characteristics, management and in-hospital mortality of patients with coronavirus disease 2019 in Genoa, Italy

Author

Alessandrini, Anna, Camera, Marco, Delfino, Emanuele, De Maria, Andrea, Dentone, Chiara, Di Biagio, Antonio, Dodi, Ferdinando, Ferrazin, Antonio, Mazzarello, Giovanni, Mikulska, Malgorzata, Nicolini, Laura, Toscanini, Federica, Giacobbe, Daniele R., Vena, Antonio, Taramasso, Lucia, Balletto, Elisa, Portunato, Federica, Schenone, Eva, Rosseti, Nirmala, Baldi, Federico, Berruti, Marco, Briano, Federica, Dettori, Silvia, Labate, Laura, Magnasco, Laura, Mirabella, Michele, Pincino, Rachele, russo, Chiara, Sarteschi, Giovanni, sepulcri, Chiara, Tutino, Stefania, Pontremoli, Roberto, Beccati, Valentina, Casciaro, Salvatore, Casu, Massimo, Gavaudan, Francesco, Ghinatti, Maria, Gualco, Elisa, Leoncini, Giovanna, pitto, Paola, salam, Kassem, Gratarola, Angelo, Bixio, Mattia, Amelia, Annalisa, Balestra, Andrea, Ballarino, Paola, Bardi, Nicholas, Boccafogli, Roberto, Caserza, Francesca, Calzolari, Elisa, Castelli, Marta, Cenni, Elisabetta, Cortese, Paolo, Cuttone, Giuseppe, Feltrin, Sara, Giovinazzo, Stefano, Giuntini, Patrizia, Natale, Letizia, Orsi, Davide, Pastorino, Matteo, Perazzo, Tommaso, Pescetelli, Fabio, Schenone, Federico, Serra, Maria G., Sottano, Marco, Tallone, Roberto, Amelotti, Massimo, Majabò, Marie J., Merlini, Massimo, Perazzo, Federica, Ahamd, Nidal, Barbera, Paolo, Bovio, Marta, Campodonico, Paola, Collidà, Andrea, Cutuli, Ombretta, Lomeo, Agnese, Fezza, Francesca, Gentilucci, Nicola, Hussein, Nadia, Malvezzi, Emanuele, Massobrio, Laura, Motta, Giula, Pastorino, Laura, Pollicardo, Nicoletta, Sartini, Stefano, Vacca, Paola, Virga, Valentina, Porto, Italo, Bezante, Giampaolo, Della Bona, Roberta, La Malfa, Giovanni, Valbusa, Alberto, Ad, Vered G., Barisione, Emanuela, Bellotti, Michele, Teresita, Aloe’, Blanco, Alessandro, Grosso, Marco, Piroddi, Maria Grazia, Moscatelli, Paolo, Caiti, Matteo, Magnani, Ottavia, Sukkar, Samir, Cogorno, Ludovica, Gradaschi, Raffaella, Guiddo, Erica, Martino, Eleonora, Pisciotta, Livia, Cavagliere, Bruno, Cristina, Rossi, Francesca, Farina, Garibotto, Giacomo, Esposito, Pasquale, Bellezza, Carmen, Harusha, Emirjona, Rossi, Francesca, Arboscello, Eleonora, Arzani, Laura, De Mattei, Laura, Spadaro, Marzia, Passalacqua, Giovanni, Bagnasco, Diego, Braido, Fulvio, Riccio, Annamaria, Tagliabue, Elena, Gustavino, Claudio, Ferraiolo, Antonella, Monacelli, Fiammetta, Mahmoud, Mona, Tagliafico, Luca, Napolitano, Armando, Fiorio, Maria, Pizzonia, Monica, Giannotti, Chiara, Nencioni, Alessio, Giuffrida, Salvatore, Rosso, Nicola, Morando, Alessandra, Papalia, Riccardo, Passerini, Donata, Tiberio, Gabriella, Orengo, Giovanni, Battaglini, Alberto, Ruffoni, Silvano, Caglieris, Sergio, Giacobbe, Daniele Roberto, Ball, Lorenzo, Brunetti, Iole, Loconte, Maurizio, Patroniti, Nicolò A., Robba, Chiara, Bavastro, Martina, Cerchiaro, Matteo, Giacomini, Mauro, Mora, Sara, Sepulcri, Chiara, Russo, Chiara, Pelosi, Paolo, and Bassetti, Matteo

Published
2020
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17. Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia

Author

Rispoli, Vincenzo, Malara, Alba, Spadea, Fausto, Di Cello, Serena, Ceravolo, Francesco, Fabiano, Francesco, Chiaradia, Giuseppe, Gabriele, Amedeo, Lenino, Peluso, Andrea, Taristano, Settembrini, Vincenzo, Capomolla, Domenico, Citrino, Antonella, Scriva, Antonietta, Bruno, Irene, Secchi, Roberto, De Martino, Eugenio, Muccinelli, Roberto, Lupi, Gerardo, Paonessa, Patrizio, Fabbri, Andrea, Passuti, Maria Teresa, Castellari, Sofia, Po, Andrea, Gaggioli, Guido, Varesi, Massimo, Moneti, Paolo, Capurso, Sebastiano, Latini, Vincenzo, Ghidotti, Stefano, Riccardelli, Francesco, Macchi, Maurizio, Rigo, Rosaria, Claudio, Pascale, Angelo, Bosio, Flavio, Cerrato, Benedetta, Bardelli, Boffelli, Stefano, Cassinadri, Angela, Franzoni, Simone, Spazzini, Elena, Andretto, Daniela, Tonini, Gabriele, Andreani, Laura, Coralli, Mirco, Balotta, Antonio, Cancelliere, Roberto, Ballardini, Giorgio, Simoncelli, Margherita, Mancini, Annarita, Strazzacapa, Mara, Fabio, Stefano, De Filippi, Francesco, Giudice, Chiara, Dentizzi, Cosimo, Azzini, Margherita, Cazzadori, Marco, Mastroeni, Valeria, Bertassello, Paolo, Claudia Benati, Helena Santana, Nesta, Elisa, Tobaldini, Chiara, Guerini, Fabio, Elena, Tambara, Mombelloni, Paolo, Fontanini, Fulvio, Gabriella, Lassa, Pizzorni, Crosio, Oliverio, Martina, Del Grosso, Luciano Luca, Giavedoni, Cristina, Bidoli, Giuliano, Mazzei, Bruno, Corsonello, Andrea, Fusco, Sergio, Vena, Silvio, De Vuono, Tommaso, Maiuri, Giorgio, Luca, Fimognari Filippo, Andrea, Arone, Giovanni, Sgrò, Rossella, Nicolazzo, Castegnaro, Eugenio, De Rosa, Salvatore, Sechi, Rossella Bazzano, Benvenuti, Enrico, Del Lungo, Ilaria, Giardini, Sante, Giulietti, Chiara, Mauro, Di Bari, Eleonora, Barghini, Martina, Paoli, Irene, Fiordelli, Riccardo, Barucci, Federica, Sgrilli, Ilaria, Del Lungo, Bertoletti, Erik, D'Amico, Ferdinando, Caronzolo, Francesco, Grippa, Alessandro, Lombardo, Giuseppina, Pipicella, Tiziana, Antonino, Saitta, Francesco, Corica, Valeria, Prestipino Giarritta, Daniela, Larosa, Domenico, Cucinotta, Giorgio, Basile, March, Albert, Nitti, Maria Teresa, Felici, Alessandro, Pavan, Silvia, Piazzani, Fabrizio, Lunelli, Alessandra, Dimori, Sergio, Margotta, Alessandro, Soglia, Tiziano, Postacchini, Demetrio, Brunelli, Roberto, Santini, Silvia, Francavilla, Monia, Macchiati, Ilenia, Sorvillo, Francesca, Giuli, Cinzia, Mecocci, Patrizia, Longo, Annalisa, Perticone, Francesco, Addesi, Desireè, Rosa, Paola Cerra, Bencardino, Giuseppe, Falbo, Tania, Grillo, Nadia, Marco, Filice, Mirella, Flippo, Fantò, Fausto, Isaia, Gianluca, Pezzilli, Stella, Bergamo, Daniele, Furno, Elisabetta, Rrodhe, Sokol, Lucarini, Simonetta, Dijk, Babette, Dall'Acqua, Francesca, Cappelletto, Francesco, Calvani, Donatella, Becheri, Dimitri, Giuseppe, Mottino, Costanza, Mitidieri, Vito, Antonio, Francesca, Bartalucci, Magherini, Lorenza, Novella, Malin, Franca, Boni, Lucia Gambardella, Paoli Martina, Valente, Carlo, Ilaria, Bracali, Alice, Foschini, Bo, Mario, Porrino, Paola, Ceci, Giacomo, Giuliana, Bottignole, Michela, Tibaldi, Eleonora, Coppo, Ettore, Evaristo, Camellini, Cinzia, Servello, Adriana, Grassi, Alessandro, Rozzini, Renzo, Tironi, Sara, Grassi, Maria Grazia, Troisi, Elio, Carlo, Caltagirone, Simona Gabriella, Di Santo, Flaminia, Franchini, Federica, Ratto, Beatrice, Pavoni, Sofia, Toniolo, Gabutto, Anna, Quazzo, Loredana, Rosatello, Annalisa, Suraci, Domenico, Tagliabue, Benedetta, Perrone, Chiara, Ferrara, Lucia, Castagna, Alberto, Tremolada, Maria Luisa, Giuseppe, Castoldi, Stefano, Barbero, Davide, Oltramonti, Piano, Simonetta, Serviddio, Gaetano, Lo Buglio, Aurelio, Gurrera, Tiziana, Merlo, Valeria, Rovai, Carla, Cotroneo, Antonino Maria, Carlucci, Rosaria, Abbaldo, Anna, Monzani, Fabio, Qasem, Ahmad Amedeo, Bini, Giacomo, Tafuto, Silvia, Galli, Giovanni, Bruni, Amalia Cecilia, Mancuso, Giovanna, Mancuso, Gerardo, Calipari, Daniela, Giuseppe Massimiliano, De Luca, Bernardini, Bruno, Corsini, Carla, Michele, Ciccarelli, Sara, Dal Farra, Cagnin, Annachiara, Fragiacomo, Federica, Pompanin, Sara, Piero, Amodio, Marco, Cagnin, Zurlo, Amedeo, Guerra, Gianluca, Pala, Marco, Menozzi, Luca, Gatti, Chiara Delli, Magon, Stefania, Roberto, Manfredini, Alfredo, De Giorgi, Fabio, Fabbian, Ruana, Tiseo, Elisa, Misurati, Benedetta, Boari, Christian, Molino, Marco, Pala, Massimo, Gallerani, Di Francesco, Vincenzo, Faccioli, Silvia, Pellizzari, Luca, Giorgia, Fontana, Barbagallo, Giuseppe, Lunardelli, Maria Lia, Martini, Emilio, Ferrari, Eleonora, Macchiarulo, Maria, Corneli, Maria, Bacci, Monica, Battaglia, Giuseppe, Anastasio, Luigi, Lo Storto, Mario Sostene, Seresin, Chiara, Simonato, Matteo, Loreggian, Michele, Cestonaro, Fausta, Durando, Mario, Latella, Raffaele, Mazzoleni, Marta, Russo, Giuseppe, Ponte, Martino, Valchera, Alessandro, Salustri, Giuseppe, Petritola, Donatella, Costa, Alfredo, Sinforiani, Elena, Cotta, Matteo Ramusino, Pizio, Renato Nicola, Cester, Alberto, Formilan, Marino, Pietro, Bonometto, Carbone, Pasqualina, Cazzaniga, Ilaria, Appollonio, Ildebrando, Cereda, Diletta, Stabile, Andrea, Xhani, Rubjona, Acampora, Roberto, Tremolizzo, Lucio, Federico, Pieruzzi, Antonio, Ciaccio, Valerio, Pontecorvi, Cesare, Burti, Zhirajr, Mokini, Giovanni, Vitale, Maria, Amigoni, Mariaelena, Sparacino, Bottacchi, Edo, Bucciantini, Elisabetta, Di Giovanni, Marco, Franchi, Fabrizio, Lucchetti, Lucio, Mariani, Claudio, Grande, Giulia, Rapazzini, Piero, Marco, Mauri, Romanelli, Giuseppe, Marengoni, Alessandra, Franco, Nicosia, Alessio, Margola, Stefano, Bonardelli, Nicola, Latronico, Laura, Porcella, Nazario, Portolani, Carlo, Concoreggi, Chiara, Grassini, Soccorso, Pronto, Andrea, Salvi, Luca, Bianchetti, Francesca, Spagnoli, Roberto, Apuzzo, Marco, Fontanella, Anna, Ceraso, Francesco, Castelli, Fugazza, Luciano, Guerrini, Chiara, De Paduanis, Giovanna, Iallonardo, Lucia, Palumbo, Pasquale, Zuliani, Giovanni, Ortolani, Beatrice, Capatti, Eleonora, Soavi, Cecilia, Bianchi, Lara, Francesconi, Daniela, Miselli, Agata, Gloria, Brombo, Tommaso, Romagnoli, Chiara, Pazzaglini, Agata, Miselli Maria, Marco, Dall'Agata, Luca, Menozzi, Gianluca, Guerra, Suardi, Teresa, Mazzone, Andrea, Zaccarini, Cinzia, Manuela, Riva, Mirra, Gianluca, Muti, Ettore, Bottura, Renato, Gianpaolo, Moretti, Secreto, Piero, Bisio, Erika, Cecchettani, Marco, Naldi, Tamara, Pallavicino, Alessandra, Pugliese, Michela, Iozzo, Rosaria Cosima, Grassi, Guido, Michele, Bombelli, Raffaella, Dell'Oro, Fosca, Quarti Trevano, Giorgio, Giussani Carlo, Giovanni, Paternò, Ernesto, Contro, Mannironi, Antonio, Giorli, Elisa, Oberti, Sara, Fierro, Brigida, Piccoli, Tommaso, Giacalone, Fabio, Mandas, Antonella, Serchisu, Luca, Costaggiu, Diego, Pinna, Elisa, Orrù, Francesca, Mannai, Martina, Cordioli, Zeno, Pelizzari, Luca, Turcato, Emanuela, Arduini, Pietro, Cacace, Carlo, Chiloiro, Roberta, Cimino, Rosella, Ruberto, Carmen, Giovanni, Ruotolo, Pietro, Gareri, Laura, Greco, Alberto, Castagna, Carmen, Ruberto, Santo, Pierluigi Dal, Andriolli, Antonino, Burattin, Giuseppe, Rossi, Laura, Andreolli Antonino, Cervati Giovanna, Giuseppe, Catalano, Tezza, Fabiana, Maddalena, Pizzardini, Laura, Stievano, Crippa, Patrizia, Aloisio, Paola, Di Monda, Tiziana, Malighetti, Alessandro, Galbassini, Gloria, Salutis, Domus, Ivaldi, Claudio, Russo, Anna Maria, Bennati, Ettore, Pino, Elisabetta, Zavarise, Gianmaria, Pesci, Alberto, Suigo, Giulia, Faverio, Paola, Andrea, Gori, Sabrina, Perego, Zanasi, Massimo, Moniello, Giovanni, Rostagno, Carlo, Cartei, Alessandro, Polidori, Gianluca, Ungar, Andrea, Melis, Maria Ramona, Martellini, Eleonora, Enrico, Mossello, Monica, Torrini, Antonella, Giordano, Giovanna, Leone, Migliorini, Marta, Caramelli, Francesca, Battiston, Bruno, Berardino, Maurizio, Cavallo, Simona, Alessandro, Massè, Anna, Santoro, Lombardi, Bruna, D'Ippolito, Pierpaolo, Furini, Angela, Villani, Daniele, Clara, Raimondi, Guarneri, Massimo, Paolucci, Stefano, Bassi, Andrea, Coiro, Paola, De Angelis, Domenico, Morone, Giovanni, Venturiero, Vincenzo, Palleschi, Lorenzo, Raganato, Paolo, Di Niro, Giuseppina, Rosa, Casini Anna, Loredana, Bove, Imoscopi, Alessandra, Isaia, Giancarlo, Tibaldi, V., Bottignole G, G., Calvi, E., Clementi, C., Zanocchi, M., Agosta, L., Nortarelli, Antonella, Provenzano, Giuseppe, Mari, Daniela, Romano, Federica Ylenia, Rosini, Francesca, Mansi, Marta, Rossi, Silvia, Geriatria, Alex Riccardelli, Inzaghi, Lorenzo, Bonini, Giulia, Rossi, Paolo, Potena, Alfredo, Lichii, Mihaela, Candiani, Tiziana, Grimaldi, William, Bertani, Emiliano, Alessandra, Porta, Calogero, Pietro, Pinto, Daniela, Bernardi, Roberto, Nicolino, Francesco, Galetti, Caterina, Gianstefani, Alice, Giulia, Corvalli, Lorenzo, Mulazzani, Odetti, Patrizio, Monacelli, Fiammetta, Prefumo, Matteo, Fiammetta, Monacelli, Canepa, Marta, Minaglia, Cecilia, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Prestano, Raffaele, Dalise, Anna Maria, Barra, Davide, Bosco, Livio Dal, Asprinio, Vincenzo, Dallape, Luciana, Perina, Elisa, Incalzi, Raffaele Antonelli, Bartoli, Isaura Rossi, Pluderi, Alice, Maina, Antonella, Pecoraro, Elisabetta, Sciarra, Michela, Prudente, Angela, Paola, Maina, Francesca, Mete, Manuel, Ventura, Luisella, Cesari, Maria, Pernigotti Luigi, Tina, Santangelo, Benini, Lucia, Levato, Francesco, Mhiuta, Victor, Alius, Florin, Davidoaia, Diana, Giardini, Vittorio, Garancini, Mattia, Bellamoli, Claudio, Terranova, Luciano, Bozzini, Claudia, Tosoni, Paolo, Provoli, Emma, Cascone, Luisa, Dioli, Andrea, Ferrarin, Gianfranco, Bucci, Adelmo, Bua, Guido, Fenu, Sara, Bianchi, Giovanna, Casella, Silvia, Romano, Valentina, Maurizio, Poli, Mascherona, Ilenia, Belotti, Gloria, Cavaliere, Sabina, Cuni, Estella, Merciuc, Nina, Oberti, Rosella, Veneziani, Silvia, Capoferri, Emanuela, De Bernardi, Elisabetta, Colombo, Katia, Bravi, Marco, Nicoletta, Negrinotti, D'Arcangelo, Paolo, Montenegro, Nicola, Montanari, Roberto, Lamanna, Pierpaolo, Gasperini, Beatrice, Isabella, Montesi, Stefania, Diotallevi, Gaia, Altobelli, Filippo, Calcinaro, Palamà, Chiara, Di Emidio, Chiara, Scarpini, Elio, Arighi, Andrea, Fumagalli, Giorgio, Basilico, Paola, De Amicis Margherita, Migone, Marta, Mancarella, Diletta, Maira, Granata, Antonino, Ranalli, Claudia, Cammilli, Alessandra, Cavallini, Maria Chiara, Tricca, Manola, Natella, Daniela, Gabbani, Luciano, Tesi, Francesca, Martella, Letizia, Imbrici, Rosalba, Guerrini, Gianbattista, Scotuzzi, Anna Maria, Sozzi, Ferdinando, Valenti, Luigi, Chiarello, Antonino, Monia, Monella, Pilotto, Alberto, Prete, Camilla, Senesi, Barbara, Meta, Anna Cristina, Pendenza, Enrico, Pasqualetti, Giuseppe, Polini, Antonio, Tognini, Sara, Ballino, Elena, Cherubini, Antonio, Dell'Aquila, Giuseppina, Gasparrini, Pina Maria, Marotti, Elisabetta, Migale, Monica, Scrimieri, Antonia, Falsetti, Lorenzo, Salvi, Aldo, Toigo, Gabriele, Ceschia, Giuliano, Rosso, Alessia, Tongiorgi, Chiara, Scarpa, Cristina, Maurizio, Pacchioni, De Dominicis, Luigino, Pucci, Eugenio, Renzi, Sara, Cartechini, Elisabetta, Tomassini, Pia Francesca, Del Gobbo, Maurizio, Ugenti, Francesca, Romeo, Pasquale, Nardelli, Anna, Lauretani, Fulvio, Visioli, Sandra, Montanari, Ilaria, Ermini, Francesca, Giordano, Antonio, Pigato, Giorgio, Simeone, Emilio, Barbujani, Mario, Giampieri, Marina, Amoruso, Raffaele, Piccinini, Maristella, Ferrari, Camilla, Gambetti, Claudio, Sfrappini, Mario, Semeraro, Letizia, Striuli, Rinaldo, Mariani, Claudia, Pelliccioni, Giuseppe, Marinelli, Donatella, Fabi, Katia, Rossi, Tommaso, Pesallaccia, Martina, Sabbatini, Debora, Gobbi, Beatrice, Cerqua, Raffaella, Tagliani, Giancarla, Schlauser, Elena, Caser, Luciano, Caramello, Elisa, Sandigliano, Franca, Rosso, Giorgio, Ferrari, Alberto, Bendini, Chiara, Luisa, Davoli Maria, Casella, Monica, Prampolini, Raffaella, Scevola, Moreno, Vitale, Enrico, Roberto, Brugiolo, Carlo, Fagherazzi, Sergio, Fusco, Alberto, Scarpa, Daniela, Zara, Giulia, Bertozzo, Serena, Granziera, Michele, Barazzuol, Maugeri, Domenico, Sorace, Rosaria, Anzaldi, Massimiliano, De Gesu, Roberto, Morrone, Giuseppe, Davolio, Federica, Fabbo, Andrea, Palmieri, Marina, Zoli, Marco, Forti, Paola, Pirazzoli, Luca, Fabbri, Elisa, Terenzi, Laura, Bergolari, Federica, Wenter, Christian, Ruffini, Ingrid, Insam, Miriam, Abraham, Elisabeth, Kirchlechner, Christine, Cucinotta, Domenico, Antonino, Lasco, Basile, Giorgio, Grazia, Arena Maria, Parise, Pasquale, Boccali, Andrea, Amici, Serena, Gambacorta, Maurizia, Lasagni, Anna, Lovati, Roberto, Giovinazzo, Francesca, Kimak, Elzbieta, Zappa, Paolo, Medici, Francesco, Lo Castro, Marika, Mauro, Flavia, De Luca, Alessandro, Sancesario, Giuseppe, Martorana, Alessandro, Scaricamazza, Beatrice, Toniolo, Sofia, Di Lorenzo, Francesco, Liguori, Claudio, Lasco, Antonino, Vita, Natale, Giomi, Mirna, Forte, Floriana, Padovani, Alessandro, Rozzini, Luca, Ceraso, Anna, Salvatore, Caratozzolo, Cottino, Maria, Vitali, Silvia, Marelli, Eleonora, Tripi, Gabriele, Miceli, Salvatore, Urso, Giovanni, Grioni, Giuseppe, Vezzadini, Giuliana, Misaggi, Giulia, Forlani, Chiara, Avanzi, Stefano, Serena, Saulle, Claudia, Casarini, Marilena, Viggiano, Alberto, Luisa, Diego, Ghianda, Alessandro, Giordano, Iemolo, Francesco, Giordano, Antonello, Sanzaro, Enzo, D'Asta, Gabriele, Proietto, Maria, Carnemolla, Anna, Razza, Grazia, Spadaro, Daniela, Bertolotti, Marco, Mussi, Chiara, Neviani, Francesca, Roberto, Chiesa, Valentina, Guerzoni, Linda, Morselli, Francesca, Venturelli, Tarozzi, Adriano, Balestri, Francesca, Mannarino, Giulio, Bigolari, Michela, Natale, Alessia, Grassi, Simona, Bottaro, Cinzia, Stefanelli, Sara, Bovone, Ugo, Tortorolo, Umberto, Quadri, Roberto, Leone, Giuseppe, Ponzetto, Maria, Frasson, Paola, Annoni, Giorgio, Bellelli, Giuseppe, Bruni, Adriana, Confalonieri, Roberto, Corsi, Maurizio, Moretti, Daniela, Teruzzi, Fabiola, Umidi, Simona, Mazzola, Paolo, Perego, Sabrina, Persico, Ilaria, Olivieri, Giulia, Bonfanti, Alessandra, Hajnalka, Szabò, Galeazzi, Marianna, Massariello, Francesca, Anzuini, Alessandra, Caffarra, Paolo, Barocco, Federica, Spallazzi, Marco, Paolo, Ceda Gian, Simonetta, Morganti, Andrea, Artoni, Chioatto, Paolo, Bortolamei, Sandra, Soattin, Lucia, Ruotolo, Giovanni, Beneamino, Borelli, Giuseppe, Barilaro, Bertazzoli, Marco, Rota, Elisabetta, Adobati, Annamaria, Scarpa, Alberto, Granziera, Serena, Zuccher, Paola, Fabbro, Angela Dal, Zara, Daniela, Lo Nigro, Ambra, Franchetti, Lorena, Toniolo, Marika, Marcuzzo, Cinzia, Rollone, Marco, Guerriero, Fabio, Sgarlata, Carmelo, Massè, Alessandro, Zatti, Giovanni, Piatti, Massimiliano, Graci, Jole, Benati, Giuseppe, Boschi, Federica, Biondi, Mario, Fiumi, Nicoletta, Erika, Tamburini, Locatelli, Sergio Mario, Mauri, Sabrina, Beretta, Mauro, Margheritis, Laura, Desideri, Giovanbattista, Liberatore, Ester, Carucci, Anna Cecilia, Bonino, Paolo, Caput, Margherita, Antonietti, Maria Paola, Polistena, Giuseppe, De la Pierre, Franz, Mari, Marcello, Massignani, Paola, Tombesi, Fabio, Selvaggio, Fabio, Verbo, Brunella, Bodoni, Paolo, Marchionni, Niccolò, Mossello, Enrico, Sabatini, Tony, Mussio, Eleonora, Magni, Eugenio, Bianchetti, Angelo, Crucitti, Andrea, Titoldini, Giulia, Cossu, Beatrice, Fascendini, Sara, Licini, Cristina, Tomasoni, Angela, Calderazzo, Massimo, Daniela, Tropiano, Valentina, Laganà, Melotti, Rita Maria, Lilli, Albina, Buda, Simona, Adversi, Marco, Noro, Gabriele, Turco, Renato, Ubezio, M Chiara, Mantovani, Anna Roberta, Viola, Maria Cristina, Serrati, Carlo, Pretta, Stefano, Infante, Maria, Gentile, Simona, Morandi, Alessandro, D'Ambrosio, Viviana, Mazzanti, Paolo, Brambilla, Cristina, Sportelli, Silvia, Platto, Caterina, Faraci, Bianca, Quattrocchi, Daniela, Pernigotti, Luigi Maria, Pisu, Cristina, Sicuro, Francesca, Zagnoni, Piergiuseppe, Ghiglia, Stefania, Mosca, Massimiliano, Corazzin, Ileana, Deola, Mariangela, Biagini, Carlo Adriano, Bencini, Francesca, Cantini, Claudia, Tonon, Elisabetta, Pierinelli, Silvia, Onofrj, Marco, Thomas, Astrid, Filomena, Borbone, Bonanni, Laura, Gabriella, Cacchiò, Comi, Giancarlo, Magnani, Giuseppe, Santangelo, Roberto, Mazzeo, Salvatore, Giuseppe, Magnani, Francesca, Caso, Giordano, Cecchetti, Roberto, Sant'Angelo, Barbieri, Cristina, Giroldi, Liviana, Bandini, Fabio, Masina, Marco, Malservisi, Simona, Cicognani, Annalena, Ricca, Laura, Piccininni, Maristella, Tassinari, Tiziana, Brogi, Davide, Sugo, Annalisa, Alessandra, Filippi, Sonia, Manfredi, Valerio, Vanni, Andrea, Usai Carlo, Enrico, Colombo, Vera, Renna Francesca, Assunta, Sauchella, Gianmaria, Zavarise, Mauro, Prete, Pietro, Bisagni, Roberto, Masini, Salvatore, Carrabetta, Barone, Antonella, Razzano, Monica, Giuseppe, Imperoli, Angela, Bini, Francesco, Serra, Valeria, D'Agostino, Federico, Gianolla, Lucia, Pietrangeli, Antonella, Velardi, Elisabetta, Di Cello, Cristina, Rosati, Nadia, Casali, Maria, Sessa, Luciano, Abruzzi, Chiara, Costanzi, Bini, Paolo, Pignata, Michele, Enrico, Buonagurio, Maria, Vollery, Giovanni, Carrieri, Giorgio, Cioni, Andrea, Toschi, Marco, Metra, Piera, Ranieri, Alberto, Zucchelli, Ceccon, Anna, Magrin, Laura, Marin, Sara, Barbara, Sofia, Marco, Masina, Laura, Ghedini, Matteo, Moroni, Marco, Paragona, Caterina, Pallotti Maria, Carla, Rota, Federica, Gottardi, Clara, Tomasoni, Melania, Cappuccio, Giampaolo, Bonini, Stefano, Guerini, Valeria, Guerini, Lucia, Merla, Giovambattista, Desideri, Ester, Liberatore, Cecilia, Carucci Anna, Maurizio, Tovaglieri, Vera, Renna Frandesca, Nadia, Bongiorni, Grillo, Antonio, Arenare, Francesca, Tonino, Mineo, David, Kanah, Giorgio, Vianello Piero, Ubaldo, Balducci, Vincenzo, Sidoti, Stefano, Montanari, Marino, Formilan, Busonera Flavio, Murelli Teodolindo, Paolo, Albanese, Monica, Maselli, Francesco, Bolzetta, Roberto, Fabris, Paolo, Bonino, DuranteMangoni, Emanuele, Testoni, Michela, Fabio, Di Stefano, Loredana, Seccia, Valeria, Sonzini, Fabiano, Maria, Annabella, Di Giorgio, Salvatore, De Cosmo, Greco, Antonio, Grazia, D'Onofrio, Daniele, Sancarlo, Gianluca, Resta, Renzo, Girardello, Sergio, Minervini, Morena, Boni, Vitali, Mariagrazia, Marina, Pizzoni, Paolo, De Colle, Cristina, Scarpa, Alessandra, Frattola, Orlandini, Francesco, La Regina, Micaela, Desirée, Addesi, Mirella, Filippo, Mario, Bo, Paola, Porrino, Padulo, Filomena, Cristina, Margheriti, Dario, Rolano, Giancarla, Moscatelli, Guido, Radaelli, Elena, Montini, Prete, Cosimo, Marileda, Novello, Igor, Bramuzzo, Nicole, Bertin, Elena, Rinaldo, Paolillo, Ciro, Riccardi, Angela, Claudia, Benedetti, Barbara, Rizzi, Francesca, Montagna, Silvia, Vitali, Chiara, Cutaia, Oliver, Baca, Mauro, Colombo, Eleonora, Marelli, Giuseppe, Procino, Rosaria, Tararà, Maria, Cottino, Davide, Dell'Acqua, Stefania, Cislaghi, Marco, Cairati, Massimo, Porta, Luca, Scaglione, Martina, De Feo, Paola, Vertolli, Lia, Salvati, Sandro, Cinotti, Valentina, De Santis, Erminia, Biferi, Paola, Cheli, Romina, Rebizzo, Minisola, Salvatore, Luciano, Colangelo, Pasquale, Abete, Ilaria, Liguori, Francesca, Curcio, Guglielmo, Spassini, Marco, Engheben, Sara, Rotunno, Paola, Arosio, Claudio, Angelini, Francesco, Reggiani, Alessandro, Cappelli, Simona, Marcheselli, Lara, Fratticci, Paola, Ranzani, Simonetta, Cesarini, Antonella, Cerini, Generoso, Uomo, Fernando, Gallucci, Giuliano, Ceschia, Emanuela, Serra, Mariolina, Sola, Alessandro, Delitala, Chiara, Pes, Giulia, Lobianco, Alessandro, Giani, Famularo, Simone, Sandini, Marta, Pinotti, Enrico, Gianotti, Luca, Antonella, Battuello, Giulia, Pintore, Sante, Giardini, Rossi, Andrea, Rubele, Sofia, Sant, Selena, Marco, Vignati, Danila, Clerici, Fabio, Rosa, Bandirali, Maria Pia, Nicoletta, Cattaneo, Laura, Boffi, Paolo, Tosoni, Luciano, Terranova, Leonello, Avalli, Margherita, Scanziani, Stefania, De Notaris, Pierluigi, Del Santo, Laura, Rossi, Fabiana, Tezza, Giovanna, Cervati, Antonino, Andreolli, Felice, Catalano, Giuseppe, Burattin, Danilo, Fogli, Giovanna, Di Bella, Francesco, Landi, Salini, Sara, Angela, Brunetti Maria, Giorgetta, Cappa, Giovanni, Galvagno, Paola, Cena, Gerardo, Bruno, Silvio, Raspo, Letizia, Semeraro, Sabrina, Pedrotti, Davide, Barra, Rosaria, Rizzo Maria, Maria, Dalise Anna, Raffaele, Prestano, Palmieri, Vincenzo Ostilio, Palasciano, Giuseppe, Belfiore, Anna, Portincasa, Piero, Carlo, Sabbà, Vincenzo, Solfrizzi, Alessia, D'introno, Valiani, Vincenzo, Carolina, Bologna, Tiziana, Ciarambino, Paola, Turelli, Ugo, Pazzaglia, Federica, Rodella, Giacomo, Piana, Castellano, Maurizio, Anna, Garelli, Elisa, Casella, Federica, Campana, Antonietta, Coschignano Maria, Luigi, Marinangeli, Fabio, Lorico, Salvatore, Bazzano, Giuseppe, Menculini, Gelosa, Giorgio, Viviana, Ambrogio Teresa, Piras, Valentina, Andrea, Ciricugno, Alessandra, Bollari, Coen, Daniele, Magliola, Renata, Milanesio, Deborah, Muzzulini, Carlo Lorenzo, Paolo, Fogliacco, Marinella, Turla, Sofia, Cotelli Maria, Marta, Bianchi, Siano, Pietro, Capo, Giuseppe, Napoletano, Rosa, Cecilia, Politi, Mancini, Concetta, Del Buono, Corrado, De Bartolomeo, Giuseppe, Addolorata, Martinelli, Carmen, Cefalogli, Roberto, Cozzi, Giovanni, Virtuani Angelo, Moschettini, Gianfilippo, Franco, Mastroianni, Daniela, Roglia, D'Amico, Gabriella, Mirella, Palella, Endrizzi, Cristina, Trotta, Lucia, Ciarambino, Tiziana, Orazio, Zanetti, Emanuela, Terazzi, Marta, Sacchetti, Thomas, Fleetwood, Giacomo, Tondo, Ignazio, Di Fazio, Andrea, Bruni, Giuseppe, Orsitto, Emanuela, Fabbro, Serena, Amici, Elena, D'Imporzano, Anna, Casanova, Serena, Bertolio, Erika, Nervo, Roberto, Silvestri, Elena, Semproni, Manuela, Pintus, Francesca, Aloe, Angelo, Tagliaccica, Zambon, Antonella, and Di Santo, Simona G.

Published
2020
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19. SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice

Author

Becherini, Pamela, Caffa, Irene, Piacente, Francesco, Damonte, Patrizia, Vellone, Valerio G., Passalacqua, Mario, Benzi, Andrea, Bonfiglio, Tommaso, Reverberi, Daniele, Khalifa, Amr, Ghanem, Moustafa, Guijarro, Ana, Tagliafico, Luca, Sucameli, Marzia, Persia, Angelica, Monacelli, Fiammetta, Cea, Michele, Bruzzone, Santina, Ravera, Silvia, and Nencioni, Alessio

Published
2021
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20. Fasting-mimicking diet and hormone therapy induce breast cancer regression

Author

Caffa, Irene, Spagnolo, Vanessa, Vernieri, Claudio, Valdemarin, Francesca, Becherini, Pamela, Wei, Min, Brandhorst, Sebastian, Zucal, Chiara, Driehuis, Else, Ferrando, Lorenzo, Piacente, Francesco, Tagliafico, Alberto, Cilli, Michele, Mastracci, Luca, Vellone, Valerio G., Piazza, Silvano, Cremonini, Anna Laura, Gradaschi, Raffaella, Mantero, Carolina, Passalacqua, Mario, Ballestrero, Alberto, Zoppoli, Gabriele, Cea, Michele, Arrighi, Annalisa, Odetti, Patrizio, Monacelli, Fiammetta, Salvadori, Giulia, Cortellino, Salvatore, Clevers, Hans, De Braud, Filippo, Sukkar, Samir G., Provenzani, Alessandro, Longo, Valter D., and Nencioni, Alessio

Published
2020
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22. Effect of Geriatric Comanagement in Older Patients Undergoing Surgery for Gastrointestinal Cancer: A Retrospective, Before-and-After Study

Author

Giannotti, Chiara, Massobrio, Andrea, Carmisciano, Luca, Signori, Alessio, Napolitano, Armando, Pertile, Davide, Soriero, Domenico, Muzyka, Mariya, Tagliafico, Luca, Casabella, Andrea, Cea, Michele, Caffa, Irene, Ballestrero, Alberto, Murialdo, Roberto, Laudisio, Alice, Incalzi, Raffaele Antonelli, Scabini, Stefano, Monacelli, Fiammetta, and Nencioni, Alessio

Published
2022
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24. Inhibitors of NAD + Production in Cancer Treatment: State of the Art and Perspectives.

Author

Ghanem, Moustafa S., Caffa, Irene, Monacelli, Fiammetta, and Nencioni, Alessio

Subjects
NICOTINAMIDE, DRUG discovery, CANCER treatment, ANIMAL models in research, ANTINEOPLASTIC agents
Abstract

The addiction of tumors to elevated nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of cancer metabolism. Obstructing NAD+ biosynthesis in tumors is a new and promising antineoplastic strategy. Inhibitors developed against nicotinamide phosphoribosyltransferase (NAMPT), the main enzyme in NAD+ production from nicotinamide, elicited robust anticancer activity in preclinical models but not in patients, implying that other NAD+-biosynthetic pathways are also active in tumors and provide sufficient NAD+ amounts despite NAMPT obstruction. Recent studies show that NAD+ biosynthesis through the so-called "Preiss-Handler (PH) pathway", which utilizes nicotinate as a precursor, actively operates in many tumors and accounts for tumor resistance to NAMPT inhibitors. The PH pathway consists of three sequential enzymatic steps that are catalyzed by nicotinate phosphoribosyltransferase (NAPRT), nicotinamide mononucleotide adenylyltransferases (NMNATs), and NAD+ synthetase (NADSYN1). Here, we focus on these enzymes as emerging targets in cancer drug discovery, summarizing their reported inhibitors and describing their current or potential exploitation as anticancer agents. Finally, we also focus on additional NAD+-producing enzymes acting in alternative NAD+-producing routes that could also be relevant in tumors and thus become viable targets for drug discovery. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Multiparametric Evaluation of Geriatric Patients Admitted to Intermediate Care: Impact on Geriatric Rehabilitation

Author

Murdaca, Giuseppe, primary, Banchero, Sara, additional, Casciaro, Marco, additional, Paladin, Francesca, additional, Tafuro, Michele, additional, Monacelli, Fiammetta, additional, Nencioni, Alessio, additional, Bruschetta, Roberta, additional, Pioggia, Giovanni, additional, Tartarisco, Gennaro, additional, and Gangemi, Sebastiano, additional

Published
2023
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27. Frailty, psychological well‐being, and social isolation in older adults with cognitive impairment during the SARS‐CoV‐2 pandemic: data from the GeroCovid initiative

Author

Terziotti, Camilla, primary, Ceolin, Chiara, additional, Devita, Maria, additional, Raffaelli, Cecilia, additional, Antenucci, Sara, additional, Bazzano, Salvatore, additional, Capasso, Andrea, additional, Castellino, Manuela, additional, Signore, Stefania Del, additional, Lubian, Francesca, additional, Maiotti, Mariangela, additional, Monacelli, Fiammetta, additional, Mormile, Maria Teresa, additional, Sgarito, Claudia, additional, Vella, Filomena, additional, Sergi, Giuseppe, additional, Gareri, Pietro, additional, Trevisan, Caterina, additional, Bellio, Andrea, additional, Fini, Filippo, additional, Malara, Alba, additional, Mossello, Enrico, additional, Fumagalli, Stefano, additional, Volpato, Stefano, additional, Monzani, Fabio, additional, Bellelli, Giuseppe, additional, Zia, Gianluca, additional, Incalzi, Raffaele Antonelli, additional, and Coin, Alessandra, additional

Published
2023
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28. Effect of SARS-CoV-2 vaccination in a vulnerable COVID-19 cohort: a real-life experience in an Italian Hospital

Author

Russo, Chiara, primary, Tagliafico, Luca, additional, Labate, Laura, additional, Ponzano, Marta, additional, Mirabella, Michele, additional, Portunato, Federica, additional, Bellezza, Carmen, additional, Mora, Sara, additional, Arboscello, Eleonora, additional, Monacelli, Fiammetta, additional, Nencioni, Alessio, additional, Signori, Alessio, additional, Bruzzone, Bianca, additional, Giacomini, Mauro, additional, Dentone, Chiara, additional, and Bassetti, Matteo, additional

Published
2023
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30. Clinical Features Associated with Delirium Motor Subtypes in Older Inpatients: Results of a Multicenter Study

Author

Boffelli, Stefano, Di Stefano, Fabio, De Filippi, Francesco, Guerini, Fabio, Bertoletti, Erik, March, Albert, Margiotta, Alessandro, Mecocci, Patrizia, Addesi, Desireè, Fantò, Fausto, Isaia, Gianluca, Dijik, Babette, Porrino, Paola, Cotroneo, Antonino Maria, Galli, Giovanni, Bruni, Amalia Cecilia, Bernardini, Bruno, Corsini, Carla, Cagnin, Annachiara, Zurlo, Amedeo, Barbagallo, Giuseppe, Lunardelli, Maria Lia, Martini, Emilio, Battaglia, Giuseppe, Latella, Raffaele, Petritola, Donatella, Sinforiani, Elena, Cester, Alberto, Formilan, Marino, Carbone, Pasqualina, Appollonio, Ildebrando, Cereda, Diletta, Tremolizzo, Lucio, Bottacchi, Edo, Lucchetti, Lucio, Mariani, Claudio, Rapazzini, Piero, Romanelli, Giuseppe, Marengoni, Alessandra, Zuliani, Giovanni, Bianchi, Lara, Suardi, Teresa, Muti, Ettore, Bottura, Renato, Sgrò, Giovanni, Mandas, Antonella, Serchisu, Luca, Crippa, Patrizia, Ivaldi, Claudio, Ungar, Andrea, Villani, Daniele, Raimondi, Clara, Mussi, Chiara, Isaia, Giancarlo, Provenzano, Giuseppe, Mari, Daniela, Odetti, Patrizio, Monacelli, Fiammetta, Incalzi, Raffaele Antonelli, Pluderi, Alice, Bellamoli, Claudio, Terranova, Luciano, Scarpini, Elio, D'Amico, Ferdinando, Cavallini, Maria Chiara, Guerrini, Gianbattista, Scotuzzi, Anna Maria, Chiarello, Antonino, Pilotto, Alberto, Tognini, Sara, Dell'Aquila, Giuseppina, Toigo, Gabriele, Ceschia, Giuliano, Piccinini, Maristella, Fabbo, Andrea, Zoli, Marco, Forti, Paola, Wenter, Christian, Basile, Giorgio, Lasagni, Anna, Padovani, Alessandro, Rozzini, Luca, Cottino, Maria, Vitali, Silvia, Tripi, Gabriele, Avanzi, Stefano, Umidi, Simona, Moretti, Daniela, Ruotolo, Giovanni, Boschi, Federica, Bonino, Paolo, Marchionni, Niccolò, Cavallini, Maria C., Fascendini, Sara, Noro, Gabriele, Turco, Renato, Ubezio, Maria C., Serrati, Carlo, Infante, Maria, Gentile, Simona, Pernigotti, Luigi M., Biagini, Carlo A., Canonico, Enzo, Bonati, Pietro, Gareri, Pietro, Caffarra, Paolo, Ceretti, Arcangelo, Castiglia, Rosanna, Gabelli, Carlo, Storto, Mario Lo, Putzu, Paolo, Bellelli, Giuseppe, Morandi, Alessandro, Di Santo, Simona, Mazzone, Andrea, Rozzini, Renzo, Zanetti, Ermellina, Bianchetti, Angelo, Bo, Mario, Mossello, Enrico, Cherubini, Antonio, Ferrara, Nicola, Ferrari, Alberto, Musicco, Massimo, Trabucchi, Marco, Di Santo, Simona G., and Meagher, David

Published
2017
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32. Fasting and Cognitive Impairment.

Author

Tagliafico, Luca, Nencioni, Alessio, and Monacelli, Fiammetta

Abstract

An editorial is presented by Luca Tagliafico, Alessio Nencioni, and Fiammetta Monacelli, exploring the effects of fasting on cognitive impairment. Topics include the diverse forms of intermittent fasting, the mechanisms behind its potential benefits in neurodegenerative diseases such as Alzheimer's, and the need for cautious implementation in clinical settings due to malnutrition risks.

Published
2023
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33. Identification of new FK866 analogues with potent anticancer activity against pancreatic cancer

Author

European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Associazione Italiana per la Ricerca sul Cancro, Bai, Jian-Fei [0000-0002-9128-5819], Majjigapu, Somi Reddy [0000-0001-6422-5223], Poty, Sophie [0000-0002-5496-0758], Elías-Rodríguez, Pilar [0000-0002-9117-3905], Moreno-Vargas, Antonio J. [0000-0002-5771-2012], Carmona, Ana T. [0000-0003-1058-7127], Caffa, Irene [0000-0003-1111-9915], Khalifa, Amr [0000-0002-2131-5496], Monacelli, Fiammetta [0000-0003-4303-7252], Cea, Michele [0000-0002-1530-6729], Robina, Inmaculada [0000-0003-1447-8032], Gajate, Consuelo [0000-0003-0604-6459], Mollinedo, Faustino [0000-0002-4939-2434], Nahimana, Aimable [0000-0003-4968-3167], Duchosal, Michel [0000-0003-0543-3449], Nencioni, Alessio [0000-0001-5068-8884], Bai, Jian-Fei, Majjigapu, Somi Reddy, Sordat, Bernard, Poty, Sophie, Vogel, Pierre, Elías-Rodríguez, Pilar, Moreno-Vargas, Antonio J., Carmona, Ana T., Caffa, Irene, Ghanem, Moustafa, Khalifa, Amr, Monacelli, Fiammetta, Cea, Michele, Robina, Inmaculada, Gajate, Consuelo, Mollinedo, Faustino, Bellotti, Axel, Nahimana, Aimable, Duchosal, Michel, Nencioni, Alessio, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Associazione Italiana per la Ricerca sul Cancro, Bai, Jian-Fei [0000-0002-9128-5819], Majjigapu, Somi Reddy [0000-0001-6422-5223], Poty, Sophie [0000-0002-5496-0758], Elías-Rodríguez, Pilar [0000-0002-9117-3905], Moreno-Vargas, Antonio J. [0000-0002-5771-2012], Carmona, Ana T. [0000-0003-1058-7127], Caffa, Irene [0000-0003-1111-9915], Khalifa, Amr [0000-0002-2131-5496], Monacelli, Fiammetta [0000-0003-4303-7252], Cea, Michele [0000-0002-1530-6729], Robina, Inmaculada [0000-0003-1447-8032], Gajate, Consuelo [0000-0003-0604-6459], Mollinedo, Faustino [0000-0002-4939-2434], Nahimana, Aimable [0000-0003-4968-3167], Duchosal, Michel [0000-0003-0543-3449], Nencioni, Alessio [0000-0001-5068-8884], Bai, Jian-Fei, Majjigapu, Somi Reddy, Sordat, Bernard, Poty, Sophie, Vogel, Pierre, Elías-Rodríguez, Pilar, Moreno-Vargas, Antonio J., Carmona, Ana T., Caffa, Irene, Ghanem, Moustafa, Khalifa, Amr, Monacelli, Fiammetta, Cea, Michele, Robina, Inmaculada, Gajate, Consuelo, Mollinedo, Faustino, Bellotti, Axel, Nahimana, Aimable, Duchosal, Michel, and Nencioni, Alessio

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal diseases for which chemotherapy has not been very successful yet. FK866 ((E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide) is a well-known NAMPT (nicotinamide phosphoribosyltransferase) inhibitor with anti-cancer activities, but it failed in phase II clinical trials. We found that FK866 shows anti-proliferative activity in three PDAC cell lines, as well as in Jurkat T-cell leukemia cells. More than 50 FK866 analogues were synthesized that introduce substituents on the phenyl ring of the piperidine benzamide group of FK866 and exchange its buta-1,4-diyl tether for 1-oxyprop-3-yl, (E)-but-2-en-1,4-diyl and 2- and 3-carbon tethers. The pyridin-3-yl moiety of FK866 was exchanged for chlorinated and fluorinated analogues and for pyrazin-2-yl and pyridazin-4-yl groups. Several compounds showed low nanomolar or sub-nanomolar cell growth inhibitory activity. Our best cell anti-proliferative compounds were the 2,4,6-trimethoxybenzamide analogue of FK866 ((E)-N-(4-(1-(2,4,6-trimethoxybenzoyl)piperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide) (9), the 2,6-dimethoxybenzamide (8) and 2-methoxybenzamide (4), which exhibited an IC50 of 0.16 nM, 0.004 nM and 0.08 nM toward PDAC cells, respectively.

Published
2022

34. Data from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair

Author

Piacente, Francesco, primary, Caffa, Irene, primary, Ravera, Silvia, primary, Sociali, Giovanna, primary, Passalacqua, Mario, primary, Vellone, Valerio G., primary, Becherini, Pamela, primary, Reverberi, Daniele, primary, Monacelli, Fiammetta, primary, Ballestrero, Alberto, primary, Odetti, Patrizio, primary, Cagnetta, Antonia, primary, Cea, Michele, primary, Nahimana, Aimable, primary, Duchosal, Michel, primary, Bruzzone, Santina, primary, and Nencioni, Alessio, primary

Published
2023
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35. Suppl. Figures legends from Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status

Author

Cea, Michele, primary, Cagnetta, Antonia, primary, Acharya, Chirag, primary, Acharya, Prakrati, primary, Tai, Yu-Tzu, primary, Yang, Cao, primary, Lovera, Davide, primary, Soncini, Debora, primary, Miglino, Maurizio, primary, Fraternali-Orcioni, Giulio, primary, Mastracci, Luca, primary, Nencioni, Alessio, primary, Montecucco, Fabrizio, primary, Monacelli, Fiammetta, primary, Ballestrero, Alberto, primary, Hideshima, Teru, primary, Chauhan, Dharminder, primary, Gobbi, Marco, primary, Lemoli, Roberto M., primary, Munshi, Nikhil, primary, Treon, Steven P., primary, and Anderson, Kenneth C., primary

Published
2023
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36. Figure S7 from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair

Author

Piacente, Francesco, primary, Caffa, Irene, primary, Ravera, Silvia, primary, Sociali, Giovanna, primary, Passalacqua, Mario, primary, Vellone, Valerio G., primary, Becherini, Pamela, primary, Reverberi, Daniele, primary, Monacelli, Fiammetta, primary, Ballestrero, Alberto, primary, Odetti, Patrizio, primary, Cagnetta, Antonia, primary, Cea, Michele, primary, Nahimana, Aimable, primary, Duchosal, Michel, primary, Bruzzone, Santina, primary, and Nencioni, Alessio, primary

Published
2023
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37. Supplemental Materials and Methods from Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair

Author

Piacente, Francesco, primary, Caffa, Irene, primary, Ravera, Silvia, primary, Sociali, Giovanna, primary, Passalacqua, Mario, primary, Vellone, Valerio G., primary, Becherini, Pamela, primary, Reverberi, Daniele, primary, Monacelli, Fiammetta, primary, Ballestrero, Alberto, primary, Odetti, Patrizio, primary, Cagnetta, Antonia, primary, Cea, Michele, primary, Nahimana, Aimable, primary, Duchosal, Michel, primary, Bruzzone, Santina, primary, and Nencioni, Alessio, primary

Published
2023
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38. Frailty, psychological well-being, and social isolation in older adults with cognitive impairment during the SARS-CoV-2 pandemic: data from the GeroCovid initiative

Author

Terziotti, C, Ceolin, C, Devita, M, Raffaelli, C, Antenucci, S, Bazzano, S, Capasso, A, Castellino, M, Signore, S, Lubian, F, Maiotti, M, Monacelli, F, Mormile, M, Sgarito, C, Vella, F, Sergi, G, Gareri, P, Trevisan, C, Bellio, A, Fini, F, Malara, A, Mossello, E, Fumagalli, S, Volpato, S, Monzani, F, Bellelli, G, Zia, G, Incalzi, R, Coin, A, Terziotti, Camilla, Ceolin, Chiara, Devita, Maria, Raffaelli, Cecilia, Antenucci, Sara, Bazzano, Salvatore, Capasso, Andrea, Castellino, Manuela, Signore, Stefania Del, Lubian, Francesca, Maiotti, Mariangela, Monacelli, Fiammetta, Mormile, Maria Teresa, Sgarito, Claudia, Vella, Filomena, Sergi, Giuseppe, Gareri, Pietro, Trevisan, Caterina, Bellio, Andrea, Fini, Filippo, Malara, Alba, Mossello, Enrico, Fumagalli, Stefano, Volpato, Stefano, Monzani, Fabio, Bellelli, Giuseppe, Zia, Gianluca, Incalzi, Raffaele Antonelli, Coin, Alessandra, Terziotti, C, Ceolin, C, Devita, M, Raffaelli, C, Antenucci, S, Bazzano, S, Capasso, A, Castellino, M, Signore, S, Lubian, F, Maiotti, M, Monacelli, F, Mormile, M, Sgarito, C, Vella, F, Sergi, G, Gareri, P, Trevisan, C, Bellio, A, Fini, F, Malara, A, Mossello, E, Fumagalli, S, Volpato, S, Monzani, F, Bellelli, G, Zia, G, Incalzi, R, Coin, A, Terziotti, Camilla, Ceolin, Chiara, Devita, Maria, Raffaelli, Cecilia, Antenucci, Sara, Bazzano, Salvatore, Capasso, Andrea, Castellino, Manuela, Signore, Stefania Del, Lubian, Francesca, Maiotti, Mariangela, Monacelli, Fiammetta, Mormile, Maria Teresa, Sgarito, Claudia, Vella, Filomena, Sergi, Giuseppe, Gareri, Pietro, Trevisan, Caterina, Bellio, Andrea, Fini, Filippo, Malara, Alba, Mossello, Enrico, Fumagalli, Stefano, Volpato, Stefano, Monzani, Fabio, Bellelli, Giuseppe, Zia, Gianluca, Incalzi, Raffaele Antonelli, and Coin, Alessandra

Abstract

Background: The containment measures linked to the COVID-19 pandemic negatively affected the phyco-physical well-being of the population, especially older adults with neurocognitive disorders (NCDs). This study aims to evaluate whether the frailty of NCD patients was associated with different changes in multiple health domains, in particular in relation to loneliness and social isolation, pre- and post-lockdown. Materials and Methods: Patients were recruited from 10 Italian Centers for Cognitive Disorders and Dementia. Data were collected in the pre-pandemic period (T0), during the pandemic lockdown (T1), and 6–9 months post-lockdown (T2). The UCLA Loneliness Scale-3, Activities of Daily Living (ADL), Instrumental ADL (IADL), Mini-Mental State Examination, and Neuropsychiatric Inventory (NPI) were administered. Caregivers' burden was also tested. Patients were categorized as non-frail, pre-frail, and frail according to the Fatigue, Resistance, Ambulation, Illness, and Loss of Weight scale. Results: The sample included 165 subjects (61.9% women, mean age 79.5 ± 4.9 years). In the whole sample, the ADL, IADL, and NPI scores significantly declined between T0 and T2. There were no significative variations in functional and cognitive domains between the frail groups. During lockdown we recorded higher Depression Anxiety Stress Scales and Perceived Stress Scale scores in frail people. In multivariable logistic regression, frailty was associated with an increase in social isolation, and a loss of IADL. Conclusions: We observed a global deterioration in functional and neuro-psychiatric domains irrespective of the degree of frailty. Frailty was associated with the worsening of social isolation during lockdown. Frail patients and their caregivers seemed to experience more anxiety and stress disorders during SARS-CoV-2 pandemic.

Published
2023

39. Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells

Author

Cea, Michele, Cagnetta, Antonia, Adamia, Sophia, Acharya, Chirag, Tai, Yu-Tzu, Fulciniti, Mariateresa, Ohguchi, Hiroto, Munshi, Aditya, Acharya, Prakrati, Bhasin, Manoj K., Zhong, Lei, Carrasco, Ruben, Monacelli, Fiammetta, Ballestrero, Alberto, Richardson, Paul, Gobbi, Marco, Lemoli, Roberto M., Munshi, Nikhil, Hideshima, Teru, Nencioni, Alessio, Chauhan, Dharminder, and Anderson, Kenneth C.

Published
2016
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42. Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression

Author

Caffa, Irene, Spagnolo, Vanessa, Vernieri, Claudio, Valdemarin, Francesca, Becherini, Pamela, Wei, Min, Brandhorst, Sebastian, Zucal, Chiara, Driehuis, Else, Ferrando, Lorenzo, Piacente, Francesco, Tagliafico, Alberto, Cilli, Michele, Mastracci, Luca, Vellone, Valerio G., Piazza, Silvano, Cremonini, Anna Laura, Gradaschi, Raffaella, Mantero, Carolina, Passalacqua, Mario, Ballestrero, Alberto, Zoppoli, Gabriele, Cea, Michele, Arrighi, Annalisa, Odetti, Patrizio, Monacelli, Fiammetta, Salvadori, Giulia, Cortellino, Salvatore, Clevers, Hans, De Braud, Filippo, Sukkar, Samir G., Provenzani, Alessandro, Longo, Valter D., and Nencioni, Alessio

Published
2020
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46. Discrepancy Between Patient and Caregiver Estimate of Apathy Predicts Dementia in Patients with Amnestic Mild Cognitive Impairment.

Author

Grisanti, Stefano Giuseppe, Massa, Federico, Chincarini, Andrea, Pretta, Stefano, Rissotto, Roberto, Serrati, Carlo, Monacelli, Fiammetta, Serafini, Gianluca, Calcagno, Pietro, Brugnolo, Andrea, Pardini, Matteo, Nobili, Flavio, Girtler, Nicola, Dementia Disease Management Team, Schenone, Angelo, Nencioni, Alessio, Amore, Mario, Biffa, Gabriella, Sambuceti, Gianmario, and Morbelli, Silvia

Subjects
AMNESTIC mild cognitive impairment, DEMENTIA patients, CAREGIVERS, APATHY, ALZHEIMER'S disease
Abstract

Background: Apathy is a frequent behavioral symptom of Alzheimer's disease (AD). The Apathy Evaluation Scale (AES) is a tool exploring the perception of apathy by both caregivers (CG-AES) and patients (PT-AES), and the discrepancy in their ratings is a proxy of patients' disease unawareness. Objective: To assess in a cohort study of patients with amnesic mild cognitive impairment (aMCI) whether apathy and awareness of apathy predict progression to dementia and timing. Methods: From the global AES scores of 110 patients with aMCI and their caregivers, we obtained two principal indices for analysis: 1) 'Apathy', the mean of PT-AES and CG-AES, and 2) 'Discrepancy', obtained by subtracting CG-AES from PT-AES. Patients were followed with visits every six months for three years or until dementia. AES indices and the principal demographical/neuropsychological variables were filtered from multicollinearity. The most robust variables entered a logistic regression model and survival analyses (Cox regression, log-rank test of Kaplan-Meier curves) to estimate which predicted the risk and timing of progression, respectively. Results: Sixty patients (54.5%) developed dementia (57 AD) after 6.0–36.0 months, 22 (20%) remained in an MCI stage, and 28 (25.5%) dropped out. 'Discrepancy' was a robust and accurate predictor of the risk of progression (AUC = 0.73) and, after binarization according to a computed cutoff, of timing to dementia. Conclusion: A structured evaluation of apathy, both self-assessed and estimated by caregivers, can provide useful information on the risk and timing of progression from aMCI to dementia. The discrepancy between the two estimates is a fairly reliable index for prediction purposes as a proxy of disease unawareness. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery

Author

Ghanem, Moustafa S., primary, Caffa, Irene, additional, Del Rio, Alberto, additional, Franco, Jorge, additional, Parenti, Marco Daniele, additional, Monacelli, Fiammetta, additional, Cea, Michele, additional, Khalifa, Amr, additional, Nahimana, Aimable, additional, Duchosal, Michel A., additional, Ravera, Silvia, additional, Bertola, Nadia, additional, Bruzzone, Santina, additional, Nencioni, Alessio, additional, and Piacente, Francesco, additional

Published
2022
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