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Your search keyword '"Moñux Ducaju, Guillermo"' showing total 8 results
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8 results on '"Moñux Ducaju, Guillermo"'

3. FXa inhibition by rivaroxaban modifies mechanisms associated with the pathogenesis of human abdominal aortic aneurysms

Author

Moñux Ducaju, Guillermo, Zamorano León, José Javier, Marqués Pablo, Sopeña, Bernardo, García García, José Manuel, Laich de Koller, Guillermo, Calvo Rico, Bibiana, García Fernández, Miguel Ángel, Serrano, Javier, López Farre, Antonio José, Moñux Ducaju, Guillermo, Zamorano León, José Javier, Marqués Pablo, Sopeña, Bernardo, García García, José Manuel, Laich de Koller, Guillermo, Calvo Rico, Bibiana, García Fernández, Miguel Ángel, Serrano, Javier, and López Farre, Antonio José

Abstract

Aims To evaluate if rivaroxaban, an oral factor Xa (FXa) inhibitor, could modify the expression in vitro of inflammatory and oxidative stress biomarkers in abdominal aortic aneurysmal (AAA) sites showing intraluminal thrombus. Methods AAA sites with intraluminal mural thrombus were obtained from six patients undergoing elective AAA repair. In addition, control abdominal aortic samples were obtained from six organ donors. AAA sites were incubated in the presence and absence of 50 nmol l–1 rivaroxaban. Results AAA sites showing thrombus demonstrated higher content of FXa than control. Interleukin-6 levels released from AAA [Control: median: 23.45 (interquartile range: 16.17–37.15) vs. AAA: median: 153.07 (interquartile range: 100.80–210.69) pg ml–1 mg tissue–1, P < 0.05] and the expression levels of nitric oxide synthase 2 were significantly higher in AAA than in control. The protein expression level of NADPH oxidase subunits gp67-and gp91-phox, but did not gp47-phox, were also significantly higher in the AAA sites than in control. Addition of rivaroxaban to AAA sites explants significantly reduced the release of interleukin-6 [median: 51.61 (interquartile range: 30.87–74.03) pg ml–1 mg tissue–1, P < 0.05 with respect to AAA alone] and the content of nitric oxide synthase 2, gp67 and gp91-phox NADPH subunits. The content of matrix metallopeptidase 9 was significantly higher in the AAA sites as compared to control. Rivaroxaban also reduced matrix metallopeptidase 9 content in AAA sites to similar levels to control. Conclusions FXa inhibition by rivaroxaban exerted anti-inflammatory and antioxidative stress properties in human AAA sites, suggesting a role of FXa in these mechanisms associated with the pathogenesis of AAA., Depto. de Salud Pública y Materno - Infantil, Fac. de Medicina, TRUE, pub

Published
2024

7. ¿Está justificado el seguimiento ecográfico de las fístulas arteriovenosas protésicas húmero-axilares para hemodiálisis?

Author

Hernando Rydings, Manuel, Moñux-Ducaju, Guillermo, Martínez-López, Isaac, Rial-Horcajo, Rodrigo, Martínez-Izquierdo, Antonio, González-Sánchez, Sara, and Serrano-Hernando, Francisco J.

Subjects
Echographic follow-up, Prosthetic haemodialysis vascular access, Seguimiento ecográfico, Fístula protésica para hemodiálisis
Abstract

Objetivo: Evaluar el impacto de una consulta específica de accesos vasculares (C-FAV) con seguimiento intensivo en la permeabilidad de las fístulas húmero-axilares. Pacientes y método: Estudio retrospectivo. Entre enero de 2005 y diciembre de 2009 se realizan 108 fístulas húmero-axilares. Desde junio de 2007 se establece una C-FAV. Se realiza eco-doppler preoperatorio y seguimiento posterior al mes de la intervención y, después, cada 3 meses. Resultados: Se analizan las permeabilidades de 57 fístulas húmero-axilares realizadas desde junio de 2007 hasta diciembre de 2009 (grupo C-FAV), comparándolas con 51 realizadas durante los 30 meses previos (grupo control). No se encontraron diferencias en la permeabilidad obtenida entre ambos grupos a 12 y 24 meses, con una permeabilidad secundaria a los 12 meses de 49% en el grupo C-FAV y 52% en el grupo control. El porcentaje de pacientes reintervenidos fue inferior en el grupo C-FAV (35%) que en el grupo control (67%), p = 0,002. La media de reintervenciones realizadas por paciente fue menor en C-FAV que en grupo control (0,49 vs. 1,18, p = 0,01). Los pacientes del grupo C-FAV presentaron un menor número de reintervenciones por obstrucción frente al grupo control (0,42 vs. 1,04, p = 0,01). Conclusiones: En nuestra experiencia, el seguimiento intensivo no ha mejorado la permeabilidad de las fístulas húmero-axilares, disminuyendo no obstante las reintervenciones por obstrucción. El seguimiento de estos accesos debe ser clínico basado en datos de hemodiálisis, quedando la valoración ecográfica para aquellos casos con sospecha de malfunción. Aim: To evaluate the impact of a specific vascular access (arteriovenous fistula) unit (AVF-U) and intensive follow-up controls on the patency of humero-axillary fistulas (Hax-AVF). Patients and method: Retrospective study. Between January 2005 and December 2009, 108 Hax-AVF were implanted. From June 2007 an AVF-U was established. A preoperative Doppler ultrasonography analysis was performed and a follow-up control carried out a month after the intervention and subsequently every 3 months. Results: An analysis was made of the patency of 57 Hax-AVF performed between June 2007 and December 2009 (AVF-U Group), in comparison to 51 interventions performed during the previous 30 months (Control Group). No differences in the patency achieved were found at 12 or 24 months, with a secondary permeability at 12 months of 49% in the AVF-U Group and 52% in the Control Group. The percentage of patients needing to be reoperated was lower in the AVF-U Group (35%) than in the Control Group (67%) (P=.02). The mean number of re-operations per patient was lower in the AVF-U Group than in the Control Group (0.49 vs 1.18; P=.01). The patients of the AVF-U Group underwent fewer reoperations for obstruction as compared to the Control Group (0.42 vs 1.04; P=.01). Conclusions: In our experience, the intensive follow-up controls did not improve the patency of the Hax-AVF, although reoperations due to obstruction did diminish. The follow-up of these fistulas should be clinically based on haemodialysis data, leaving ultrasound evaluation for those cases where AVF failure is suspected.

Published
2012

8. Is ultrasound follow-up necessary in humero-axillary prosthetic arteriovenous fistulas for haemodialysis?

Author

Rydings MH, Moñux-Ducaju G, Martínez-López I, Rial-Horcajo R, Martínez-Izquierdo A, González-Sánchez S, and Serrano-Hernando FJ

Subjects
Aged, Arteries diagnostic imaging, Arteries surgery, Axillary Vein surgery, Female, Follow-Up Studies, Graft Occlusion, Vascular surgery, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Preoperative Care, Reoperation, Ultrasonography, Doppler, Vascular Patency, Arm blood supply, Arteriovenous Shunt, Surgical, Axillary Vein diagnostic imaging, Blood Vessel Prosthesis, Graft Occlusion, Vascular diagnostic imaging, Renal Dialysis
Abstract

Aim: To evaluate through a specific trial on vascular access fistulas (T-VAF), the impact of intensive follow-up controls on the permeability of humero-axillary fistulas (Hax-AVF)., Patients and Method: Retrospective study. Between January 2005 and December 2009, 108 Hax-AVF were implanted. From June 2007 a T-AVF was established. A preoperative duplex was performed and a follow-up control carried out a month after the intervention and subsequently every 3 months., Results: An analysis was made of the permeability of 57 Hax-AVF carried out between June 2007 and December 2009 (T-AVF Group), in comparison to 51 interventions performed during the previous 30 months (Control Group). No differences in the permeability achieved were found at 12 and 24 months, with a secondary permeability at 12 months of 49% in the T-AVF Group and 52% in the Control Group. The percentage of patients needing to be re-operated was inferior in the T-AVF Group (35%) than in the Control Group (67%) p=0.02. The re-operation per patient average was lower in the T-AVF Group than in the Control Group (0.49 vs. 1.18 p=0.01). The patients of the TAVF Group underwent a lesser number of re-operations for obstruction as opposed to the Control Group (0.42 vs 1.04 p=0.01)., Conclusions: In our experience, the intensive follow-up controls did not improve the permeability of the Hax-AVF, although re-operations due to obstruction did diminish. The follow-up of these access fistulas should be clinical based on hemodialysis data, leaving ultrasonographic evaluation for those cases where a malfunction is suspected.

Published
2012
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