16 results on '"Momoko Ichihara"'
Search Results
2. Tele‐proctoring for minimally invasive surgery across Japan: An initial step toward a new approach to improving the disparity of surgical care and supporting surgical education
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Ichiro Takemasa, Koichi Okuya, Kenji Okita, Emi Akizuki, Masaaki Miyo, Masayuki Ishii, Ryo Miura, Momoko Ichihara, Korai Takahiro, Eiji Oki, Mitsuhisa Takatsuki, Susumu Eguchi, Daisuke Ichikawa, Yuko Kitagawa, Yoshiharu Sakai, and Masaki Mori
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disparities in health care ,education ,latency ,minimally invasive surgery ,surgical supports ,tele‐proctoring ,Surgery ,RD1-811 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Aim The aim of this study was to verify the clinical feasibility of tele‐proctoring using our ultra‐low latency communication system with shared internet access. Methods Connections between two multiple remote locations at various distances were established through the TELEPRO® tele‐proctoring system. The server records the latency between the two locations for tele‐proctoring using the annotations. Questionnaires were administered to the surgeons, assistants, and medical staff. Respondents rated the quickness and quality of communication in terms of latency and disturbances in the audio, video, and usefulness of the live telestrations with annotation. Results Seven hospitals tele‐proctored with Sapporo Medical University between January 2021 and September 2022. The median latency of annotation between the two locations ranged from 24.5 to 48.5 ms. No major technological problems occurred, such as streaming interruption, loss of video or audio, poor resolution. The video encoding time was 10 ms, and its decoding time was 0.8 ms. The total latency positively correlated with the distance between two locations (R = 0.55, p
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- 2024
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3. World-first report of low anterior resection for rectal cancer with the hinotori™ Surgical Robot System: a case report
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Ryo Miura, Koichi Okuya, Emi Akizuki, Masaaki Miyo, Ai Noda, Masayuki Ishii, Momoko Ichihara, Takahiro Korai, Maho Toyota, Tatsuya Ito, Tadashi Ogawa, Akina Kimura, and Ichiro Takemasa
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Hinotori ,Rectal cancer ,Robotic surgery ,Low anterior resection ,Surgery ,RD1-811 - Abstract
Abstract Background The hinotori™ Surgical Robot System was approved for use in colorectal cancer surgery in Japan in 2022. This robot has advantages, such as an operation arm with eight axes, an adjustable arm base, and a flexible three-dimensional viewer, and is expected to be utilized in rectal cancer surgery. Herein, we report the world's first surgery for rectal cancer using the hinotori™ Surgical Robot System. Case presentation A 71-year-old woman presented to our hospital with bloody stools. A colonoscopy revealed type 2 advanced cancer in the rectum, and a histological examination exposed a well-differentiated adenocarcinoma. Abdominal enhanced computed tomography divulged rectal wall thickening without significant swelling of the lymph nodes or distant metastasis. Pelvic magnetic resonance imaging showed tumor invasion beyond the intrinsic rectal muscle layer. The patient was diagnosed with cStage IIa (cT3N0M0) rectal cancer and underwent low anterior resection using the hinotori™ Surgical Robot System. Based on an adequate simulation, surgery was safely performed with appropriate port placement and arm base-angle adjustment. The operating time was 262 min, with a cockpit time of 134 min. Subsequently, the patient was discharged 10 days postoperatively without complications. The pathological diagnosis was pStage IIA (cT3N0M0) and the circumferential resection margin was 6 mm. Conclusions We report the first case of low anterior resection for rectal cancer using the hinotori™ Surgical Robot System, in which a safe and appropriate oncological surgery was performed.
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- 2023
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4. Long noncoding RNA 01534 maintains cancer stemness by downregulating endoplasmic reticulum stress response in colorectal cancer
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Momoko Ichihara, Hidekazu Takahashi, Naohiro Nishida, Cristina Ivan, Daisuke Okuzaki, Yuhki Yokoyama, Masahisa Ohtsuka, Norikatsu Miyoshi, Mamoru Uemura, Shinji Tanaka, George Adrian Calin, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi, and Hirofumi Yamamoto
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cancer stemness ,colorectal cancer ,endoplasmic reticulum stress ,LINC01534 ,long noncoding RNA ,Surgery ,RD1-811 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background Studies have shown that cancer stemness and the endoplasmic reticulum (ER) stress response are inversely regulated in colorectal cancer (CRC), but the mechanism has not been fully clarified. Long noncoding RNAs (lncRNAs) play key roles in cancer progression and metastasis. In this study we investigated lncRNA 01534 (LINC01534) as a possible modulator between cancer stemness and ER stress response. Methods In vitro experiments using CRC cell lines were performed to explore a possible role of LINC01534. The expression of LINC01534 in clinical CRC samples was assessed by quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR) and in situ hybridization. Results Silencing LINC01534 led to suppression of cell proliferation, invasiveness, and cell cycle progression at the G2‐M phase, and promoted apoptosis. Moreover, we found that silencing LINC01534 suppressed cancer stemness, while it activated the ER stress response, especially through the PERK/eIF2α signaling pathway. In situ hybridization revealed LINC01534 was expressed in tumor cells and upregulated in CRC tissues compared with normal epithelium. A survival survey indicated that high LINC01534 expression was significantly associated with shorter overall survival in 187 CRC patients. Conclusion This is the first report on LINC01534 in human cancer. Our findings suggest that LINC01534 may be an important modulator of the maintenance of cancer stemness and suppression of the ER stress response, and that it could be a novel prognostic factor in CRC.
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- 2023
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5. Usefulness of Bacterial Culture of Drainage Fluid for Predicting Surgical Site Infection After Crohn’s Disease Surgery
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Momoko Ichihara, Takayuki Ogino, Makoto Fujii, Naotsugu Haraguchi, Hidekazu Takahashi, Norikatsu Miyoshi, Mamoru Uemura, Yuichiro Doki, Hidetoshi Eguchi, and Tsunekazu Mizushima
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bacterial culture ,CD ,drainage fluid ,SSI ,Surgery ,RD1-811 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Aim Early detection of surgical site infection (SSI) allows for appropriate management after Crohn's disease (CD) surgery. The aim of this study was to evaluate the usefulness of bacterial culture of postoperative drainage fluid after CD surgery. Methods This study included 110 patients with CD who underwent surgery with bowel resection between January 2010 and March 2020 at Osaka University Hospital. Patients with only perianal surgery or incomplete records were excluded. Risk factors for SSI were evaluated in the context of clinical findings, including bacterial culture of postoperative drainage fluid, and bacterial species related to SSI were also examined. Results Of 110 patients, 18 (16.4%) developed SSI. Organ/space SSI developed in six, and a positive bacterial culture of drainage fluid (D‐Posi) was found in five (83.3%). Of 104 patients without organ/space SSI, 31 (29.8%) were D‐Posi (P = .027). Similarly, 68.8% with incisional SSI were D‐Posi, whereas 26.6% without incisional SSI were D‐Posi (P = .0021). Multivariate analysis revealed that D‐Posi was an independent risk factor in both organ/space and incisional SSI. Bacterial examination showed that Pseudomonas aeruginosa and Enterococcus faecalis were significantly detected in patients with SSI. Conclusion This study suggests the usefulness of postoperative drainage fluid bacterial culture for early diagnosis of SSI after CD surgery.
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- 2022
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6. Simple Detection and Culture of Circulating Tumor Cells from Colorectal Cancer Patients Using Poly(2-Methoxyethyl Acrylate)-Coated Plates
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Masatoshi Nomura, Yuhki Yokoyama, Daishi Yoshimura, Yasuhisa Minagawa, Aki Yamamoto, Yukiko Tanaka, Naoko Sekiguchi, Daiki Marukawa, Momoko Ichihara, Hiroaki Itakura, Kenichi Matsumoto, Yoshihiro Morimoto, Hideo Tomihara, Akira Inoue, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Hidenori Takahashi, Mamoru Uemura, Shogo Kobayashi, Tsunekazu Mizushima, Takahisa Anada, Masaki Mori, Yuichiro Doki, Masaru Tanaka, Hidetoshi Eguchi, and Hirofumi Yamamoto
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CTC ,colorectal cancer ,PMEA ,cell culture ,spheroid ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Here we aimed to establish a simple detection method for detecting circulating tumor cells (CTCs) in the blood sample of colorectal cancer (CRC) patients using poly(2-methoxyethyl acrylate) (PMEA)-coated plates. Adhesion test and spike test using CRC cell lines assured efficacy of PMEA coating. A total of 41 patients with pathological stage II–IV CRC were enrolled between January 2018 and September 2022. Blood samples were concentrated by centrifugation by the OncoQuick tube, and then incubated overnight on PMEA-coated chamber slides. The next day, cell culture and immunocytochemistry with anti-EpCAM antibody were performed. Adhesion tests revealed good attachment of CRCs to PMEA-coated plates. Spike tests indicated that ~75% of CRCs from a 10-mL blood sample were recovered on the slides. By cytological examination, CTCs were identified in 18/41 CRC cases (43.9%). In cell cultures, spheroid-like structures or tumor-cell clusters were found in 18/33 tested cases (54.5%). Overall, CTCs and/or growing circulating tumor cells were found in 23/41 CRC cases (56.0%). History of chemotherapy or radiation was significantly negatively correlated with CTC detection (p = 0.02). In summary, we successfully captured CTCs from CRC patients using the unique biomaterial PMEA. Cultured tumor cells will provide important and timely information regarding the molecular basis of CTCs.
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- 2023
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7. Questionnaire to Survey Cosmetic Outcomes in Laparoscopic Surgery for Colorectal Cancer.
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Masaaki Miyo, Ichiro Takemasa, Koichi Okuya, Tatsuya Ito, Emi Akizuki, Tadashi Ogawa, Ai Noda, Masayuki Ishii, Ryo Miura, Momoko Ichihara, Maho Toyota, Akina Kimura, and Mitsugu Sekimoto
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- 2024
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8. Long noncoding <scp>RNA</scp> 01534 maintains cancer stemness by downregulating endoplasmic reticulum stress response in colorectal cancer
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Momoko Ichihara, Hidekazu Takahashi, Naohiro Nishida, Cristina Ivan, Daisuke Okuzaki, Yuhki Yokoyama, Masahisa Ohtsuka, Norikatsu Miyoshi, Mamoru Uemura, Shinji Tanaka, George Adrian Calin, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi, and Hirofumi Yamamoto
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Gastroenterology ,Surgery - Published
- 2022
9. Right hemicolectomy for ascending colon cancer using the hinotori surgical robot system: The first ever case report for colon cancer
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Masaaki Miyo, Kenji Okita, Koichi Okuya, Tatsuya Ito, Emi Akizuki, Tadashi Ogawa, Masayuki Ishii, Ryo Miura, Momoko Ichihara, Takahiro Korai, Akina Kimura, and Ichiro Takemasa
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General Medicine - Published
- 2023
10. Usefulness of Bacterial Culture of Drainage Fluid for Predicting Surgical Site Infection After Crohn’s Disease Surgery
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Tsunekazu Mizushima, Yuichiro Doki, Momoko Ichihara, Makoto Fujii, Hidetoshi Eguchi, Mamoru Uemura, Naotsugu Haraguchi, Takayuki Ogino, Hidekazu Takahashi, and Norikatsu Miyoshi
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medicine.medical_specialty ,Crohn's disease ,Microbiological culture ,business.industry ,Gastroenterology ,medicine ,Surgery ,Drainage ,business ,medicine.disease ,Surgical site infection - Abstract
Early detection of surgical site infection (SSI) allows for appropriate management after Crohn's disease (CD) surgery. The aim of this study was to evaluate the usefulness of bacterial culture of postoperative drainage fluid after CD surgery.This study included 110 patients with CD who underwent surgery with bowel resection between January 2010 and March 2020 at Osaka University Hospital. Patients with only perianal surgery or incomplete records were excluded. Risk factors for SSI were evaluated in the context of clinical findings, including bacterial culture of postoperative drainage fluid, and bacterial species related to SSI were also examined.Of 110 patients, 18 (16.4%) developed SSI. Organ/space SSI developed in six, and a positive bacterial culture of drainage fluid (D-Posi) was found in five (83.3%). Of 104 patients without organ/space SSI, 31 (29.8%) were D-Posi (This study suggests the usefulness of postoperative drainage fluid bacterial culture for early diagnosis of SSI after CD surgery.
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- 2021
11. Laparoscopic Abdominoperineal Resection with Left Internal Pudendal Artery Dissection and Left Lateral Lymph Node Dissection
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Masataka Ikeda and Momoko Ichihara
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medicine.medical_specialty ,Left internal pudendal artery ,Abdominoperineal resection ,business.industry ,Gastroenterology ,medicine ,Lateral lymph node ,Surgery ,Dissection (medical) ,business ,medicine.disease - Published
- 2020
12. PAX 8‐positive sarcomatoid carcinoma arising from the liver with aggressive phenotype: An autopsy case
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Masashi Ogata, Eiichi Morii, Kenji Ohshima, Hidekazu Takahashi, and Momoko Ichihara
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Pathology ,medicine.medical_specialty ,business.industry ,Medicine ,Aggressive phenotype ,General Medicine ,Autopsy case ,business ,Sarcomatoid carcinoma ,medicine.disease ,Pathology and Forensic Medicine - Published
- 2020
13. Feasibility and safety of laparoscopic lateral pelvic lymph node dissection for locally recurrent rectal cancer and risk factors for re-recurrence
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Mamoru Uemura, Masakazu Miyake, Takeshi Kato, Mitsugu Sekimoto, Momoko Ichihara, Masataka Ikeda, and Michihiko Miyazaki
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Laparoscopic surgery ,medicine.medical_specialty ,medicine.medical_treatment ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,medicine ,Adjuvant therapy ,Humans ,Radical surgery ,Lymph node ,Neoadjuvant therapy ,Retrospective Studies ,business.industry ,Rectal Neoplasms ,General Medicine ,medicine.disease ,Surgery ,Radiation therapy ,Dissection ,medicine.anatomical_structure ,Treatment Outcome ,030220 oncology & carcinogenesis ,Feasibility Studies ,Lymph Node Excision ,030211 gastroenterology & hepatology ,Laparoscopy ,Lymph Nodes ,Neoplasm Recurrence, Local ,business - Abstract
Introduction Lateral pelvic lymph node (LPLN) metastasis is considered a distant metastasis. It is often treated by systemic chemotherapy and/or radiation therapy, but complete radical resection of LPLN metastasis can sometimes achieve cure. However, the safety and efficacy of radical resection for recurrent LPLN after curative rectal surgery have not been well elucidated. Therefore, we evaluated the feasibility of laparoscopic radical surgery for recurrent LPLN compared with the conventional open approach and assessed oncological outcomes between patients with and without re-recurrence. Methods We retrospectively reviewed 17 cases (4 open, 13 laparoscopic) who underwent radical resection for LPLN metastasis after curative rectal surgery between July 2012 and August 2016 at the National Hospital Organization Osaka National Hospital. Operative factors and short-term outcomes were compared. Oncological outcome was evaluated based on the pathologic response to preoperative adjuvant therapy. Results The laparoscopic group's median blood loss and C-reactive protein elevation were lower than that of the open group on postoperative day 3. The laparoscopic group also had a shorter postoperative hospital stay. The median operative time, R0 resection rate, and morbidity rate were similar between the two groups. Local re-recurrence after LPLN resection occurred more frequently in pathologic non-responders than responders. Conclusion Laparoscopic surgery for LPLN metastasis is feasible and less invasive than open surgery. Laparoscopic radical resection of LPLN may be justified for curative intent. Patients with incomplete pathologic response to neoadjuvant therapy have a greater risk of re-recurrence.
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- 2019
14. Safety and Feasibility of Laparoscopic Pelvic Exenteration for Locally Advanced or Recurrent Colorectal Cancer
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Sakae Maeda, Takeshi Kato, Kazuhiro Nishikawa, Momoko Ichihara, Motohiro Hirao, Mitsugu Sekimoto, Masataka Ikeda, Mamoru Uemura, Atsushi Miyamoto, Masakazu Miyake, Michihiko Miyazaki, Naoki Hama, and Takuya Hamakawa
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Treatment outcome ,Operative Time ,Locally advanced ,MEDLINE ,Resection ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Medicine ,Humans ,Recurrent Colorectal Cancer ,Aged ,Retrospective Studies ,Aged, 80 and over ,Pelvic exenteration ,business.industry ,General surgery ,Retrospective cohort study ,Middle Aged ,Pelvic Exenteration ,Treatment Outcome ,030220 oncology & carcinogenesis ,Feasibility Studies ,030211 gastroenterology & hepatology ,Surgery ,Female ,Laparoscopy ,business ,Colorectal Neoplasms ,Clinical record - Abstract
Pelvic exenteration (PE) for locally advanced or recurrent colorectal cancer is often used to secure negative resection margins. The aim of this study was to evaluate the feasibility of laparoscopic PE.The clinical records of 24 patients (9, open; 15, laparoscopic) who underwent total or posterior PE for locally advanced or recurrent colorectal cancer between July 2012 and April 2016 at Osaka National Hospital were retrospectively reviewed. Operative factors were compared between the 2 groups.The R0 resection rate was 100% in the laparoscopic group and 89% in the open group. The operative time and the incidence of postoperative complications were not significantly different between the 2 groups. The laparoscopic group showed less intraoperative blood loss (P=0.019), a lower C-reactive protein elevation on postoperative day 7 (P=0.025), and a shorter postoperative hospital stay (P=0.0009).Laparoscopic PE is a safe and feasible procedure to reduce postoperative stress.
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- 2019
15. Abstract 264: Long noncoding RNA LNC01534 regulates cancer stem cells in colorectal cancer
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Yuichiro Doki, Masahisa Ohtsuka, Chu Matsuda, Hirofumi Yamamoto, Tsunekazu Mizushima, Momoko Ichihara, Wu Xin, Haruka Hirose, Hidekazu Takahashi, and Hiroki Akamatsu
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Cancer Research ,Gene knockdown ,Colorectal cancer ,Cell cycle ,Biology ,medicine.disease ,Long non-coding RNA ,Oncology ,Cancer stem cell ,Gene expression ,Unfolded protein response ,medicine ,Cancer research ,Gene - Abstract
Introduction The clinical importance of cancer stem cells (CSCs) has been widely reported, and clinical studies targeting CSCs are in progress. Additionally, accumulating evidence suggests that long noncoding RNAs (lncRNAs) have essential roles in cancer initiation and progression, while deregulated lncRNA expression is found in a variety of cancer types. In this study, we focused on lncRNAs regulating CSCs in colorectal cancer (CRC). Objectives To identify the lncRNAs associated with CSCs and to evaluate their clinical relevance and function. Materials and Methods We separated CSCs and other cells in CRC using the ornithine decarboxylase (ODC) degron system to visualize CSCs based on the correlation between low proteasome activity and CSC properties. We performed comprehensive gene analysis comparing CSCs and other cells to identify a candidate lncRNA that regulates the stemness of CRC cells. Finally, we analyzed the clinical relevance and function of the lncRNA. Results The lncRNA LNC01534 showed high expression in CSCs compared with the level in other CRC cells. Using gene expression and clinical data from the Cancer Genome Atlas Project for CRC patients, we showed that LNC01534 was associated with overall survival in CRC. LNC01534 was also associated with overall survival and disease-free survival in 187 separate CRC samples. Functional studies revealed that the loss of LNC01534 function reduced proliferation and arrested the cell cycle in CRC cells. Furthermore, genes that underwent expression changes upon the knockdown of LNC01534 were evaluated by RNA-seq. This showed that the knockdown of LNC01534 affected the expression of genes related to endoplasmic reticulum (ER) stress and autophagy. Specifically, the expression levels of HSPA5, LC3-I, p62, and Beclin-1–genes related to ER stress and autophagy–increased upon suppressing LNC01534. Conclusions We demonstrated the clinical and biological relevance of LNC01534 in association with CSCs, and discovered the effect of LNC01534 on ER stress and autophagy to maintain stemness in CRC. Citation Format: Masahisa Ohtsuka, Wu Xin, Momoko Ichihara, Haruka Hirose, Hidekazu Takahashi, Chu Matsuda, Hiroki Akamatsu, Tsunekazu Mizushima, Yuichiro Doki, Hirofumi Yamamoto. Long noncoding RNA LNC01534 regulates cancer stem cells in colorectal cancer [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 264.
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- 2020
16. [Oophorectomy for Ovarian Metastasis Occurring during Chemotherapy in Gastric Cancer Patients with Peritoneal Dissemination--Report of Three Cases]
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Momoko, Ichihara, Yoshiyuki, Fujiwara, Takeshi, Omori, Norikatsu, Miyoshi, Keijiro, Sugimura, Hirofumi, Akita, Masaaki, Motoori, Kunihito, Gotoh, Hidenori, Takahashi, Shogo, Kobayashi, Shingo, Noura, Hiroshi, Miyata, Masayuki, Ohue, Masato, Sakon, and Masahiko, Yano
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Adult ,Ovarian Neoplasms ,Gastrectomy ,Stomach Neoplasms ,Ovariectomy ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Female ,Prognosis ,Combined Modality Therapy ,Peritoneal Neoplasms ,Aged - Abstract
We report 3 cases of advanced gastric cancer with peritoneal dissemination (PD) who underwent oophorectomy for ovarian metastases that occurred during chemotherapy. Case 1: The patient was a 43-year-old woman who had type 4 advanced gastric cancer with PD. After 24 courses of S-1 plus IV and IP paclitaxel (PTX) combination therapy, oophorectomy was performed for a rapidly growing left ovarian metastasis. Thirty-four months after the start of therapy, she has completed 44 courses of S-1 plus IV and IP PTX therapy and she is continuing the treatment. Case 2: The patient was a 77-year-old woman who underwent total gastrectomy with D2-#10 lymph node dissection and cholecystectomy for gastric cancer with PD. Right ovarian resection was performed for an ovarian metastasis 30 months after gastrectomy. She continues receiving chemotherapy 8 months after oophorectomy. Case 3: The patient was a 42-year-old woman who received S-1 plus CDDP combination therapy and 22 courses of S-1 plus IV and IP PTX for gastric cancer with PD, and oophorectomy for bilateral ovarian metastases was performed. After 10 courses of S-1 plus IV and IP PTX therapy, she died of cancer. We discuss the significance of oophorectomy during chemotherapy for advanced gastric cancer with PD.
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- 2016
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