73 results on '"Momita S"'
Search Results
2. Clinical course of human T-lymphotropic virus type I carriers with molecularly detectable monoclonal proliferation of T lymphocytes: defining a low- and high-risk population
- Author
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Ikeda, S, primary, Momita, S, additional, Kinoshita, K, additional, Kamihira, S, additional, Moriuchi, Y, additional, Tsukasaki, K, additional, Ito, M, additional, Kanda, T, additional, Moriuchi, R, additional, and Nakamura, T, additional
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- 1993
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3. Semiquantitative analysis of integrated genomes of human T-lymphotropic virus type I in asymptomatic virus carriers
- Author
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Shinzato, O, primary, Ikeda, S, additional, Momita, S, additional, Nagata, Y, additional, Kamihira, S, additional, Nakayama, E, additional, and Shiku, H, additional
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- 1991
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4. VCAP-AMP-VECP Compared With Biweekly CHOP for Adult T-Cell Leukemia-Lymphoma: Japan Clinical Oncology Group Study JCOG9801.
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Tsukasaki K, Utsunomiya A, Fukuda H, Shibata T, Fukushima T, Takatsuka Y, Ikeda S, Masuda M, Nagoshi H, Ueda R, Tamura K, Sano M, Momita S, Yamaguchi K, Kawano F, Hanada S, Tobinai K, Shimoyama M, Hotta T, and Tomonaga M
- Published
- 2007
5. Detection of adult T-cell leukemia-associated antigen in T-cell malignancies in the Nagasaki district of Japan.
- Author
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Amagasaki, Tatsuhiko, Momita, Saburo, Suzuyama, Junji, Yamada, Yasuaki, Ikeda, Shuichi, Kinoshita, Kenichiro, Ichimaru, Michito, Amagasaki, T, Momita, S, Suzuyama, J, Yamada, Y, Ikeda, S, Kinoshita, K, and Ichimaru, M
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- 1984
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6. Familial disposition of adult T-cell leukemia and lymphoma.
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Ichimaru, Michito, Kinoshita, Kenichiro, Kamihira, Shimeru, Ikeda, Shuichi, Yamadia, Yasuaki, Suzuyama, Junji, Momita, Saburo, Amagasaki, Tatsuhiko, Ichimaru, M, Kinoshita, K, Kamihira, S, Ikeda, S, Yamada, Y, Suzuyama, J, Momita, S, and Amagasaki, T
- Published
- 1986
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7. Significance of soluble interleukin-2 receptor levels for evaluation of the progression of adult T-cell leukemia.
- Author
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Kamihira, Shimeru, Atogami, Sunao, Sohda, Hisashi, Momita, Saburo, Yamada, Yasuaki, Tomonaga, Masao, Kamihira, S, Atogami, S, Sohda, H, Momita, S, Yamada, Y, and Tomonaga, M
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- 1994
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8. Frequency of eosinophilia in adult T-cell leukemia/lymphoma.
- Author
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Murata, Ken, Yamada, Yasuaki, Kamihira, Shimeru, Atogami, Sunao, Tsukasaki, Kunihiro, Momita, Saburo, Amagasaki, Tatsuhiko, Sadamori, Naoki, Tomonaga, Masao, Kinoshita, Ken-Ichiro, Ichimaru, Michito, Murata, K, Yamada, Y, Kamihira, S, Atogami, S, Tsukasaki, K, Momita, S, Amagasaki, T, Sadamori, N, and Tomonaga, M
- Published
- 1992
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9. Preleukemic State of Adult T Cell Leukemia: Abnormal T Lymphocytosis Induced by Human Adult T Cell Leukemia-Lymphoma Virus
- Author
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Kinoshita, Kenichiro, Amagasaki, T., Ikeda, S., Suzuyama, J., Toriya, K., Nishino, K., Tagawa, M., Ichimaru, M., Kamihira, S., Yamada, Y., Momita, S., Kusano, M., Morikawa, T., Fujita, S., Ueda, Y., Ito, N., and Yoshida, M.
- Abstract
We report the clinical, hematologic, and immunologic features of 18 preleukemic adult T cell leukemia (pre-ATL) cases with abnormal T lymphocytosis induced by human adult T cell leukemia-lymphoma virus (HTLV/ATLV). The patients were from the Nagasaki district, which is one of the most endemic areas of ATL in Japan. Pre-ATL is a subclinical T cell abnormality differing from ATL. It is characterized by an insidious onset and appearance of abnormal T lymphocytes (10% to 40%) in the peripheral blood without clinical symptoms except for a few cases transiently presenting fever, skin eruptions, and slight lymphadenopathies. Most abnormal T lymphocytes were small and mature with incised or lobulated nuclei and formed E rosettes with sheep RBCs. Virologic and biomolecular analysis revealed that all cases were infected with HTLV, and proviral DNA was integrated in host lymphocytes from 12 of the 14 cases examined. Furthermore, the lymphocyte populations, including abnormal T lymphocytes, were monoclonal with respect to the site of the provirus integration. Abnormal T lymphocytosis persisted from one to more than seven years in six cases, three of which developed ATL after a one- to five-year pre-ATL stage, whereas abnormal T lymphocytes spontaneously decreased in the other seven patients. However, HTLV-infected monoclonal lymphocytes were detected in four cases examined, even after most of the abnormal T lymphocytes had disappeared. Moreover, the same clonally provirus-integrated lymphocytes persisted in two of four cases not only during the course of abnormal lymphocytosis, but also in the subsequent almost-normal blood. These results indicate that the majority of the cases were in a pre-ATL state with a potential to develop ATL. © 1985 by Grune & Stratton, Inc.
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- 1985
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10. Adult T-cell leukemia with colorectal involvement
- Author
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Asada, Y., Isomoto, H., Shikuwa, S., Ito, M., Momita, S., Matsumura, N., Ohba, K., Ohnita, K., Nakamura, T., Mizuta, Y., Ishibashi, H., and Kohno, S.
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- 2004
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11. DNA aneuploidy of adult T-cell leukemia cells
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Kamihira, S., Atogami, S., Sohda, H., and Momita, S.
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- 1994
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12. Relationship between monoclonal gammopathy of undetermined significance and radiation exposure in Nagasaki atomic bomb survivors.
- Author
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Iwanaga M, Tagawa M, Tsukasaki K, Matsuo T, Yokota K, Miyazaki Y, Fukushima T, Hata T, Imaizumi Y, Imanishi D, Taguchi J, Momita S, Kamihira S, and Tomonaga M
- Subjects
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Child, Female, Humans, Japan epidemiology, Male, Middle Aged, Paraproteinemias etiology, Prevalence, Radiation Dosage, Radiation Injuries complications, Risk Factors, Young Adult, Nuclear Weapons, Paraproteinemias epidemiology, Radiation Injuries epidemiology, Survivors statistics & numerical data
- Abstract
Radiation exposure is a possible predisposing factor for monoclonal gammopathy of undetermined significance (MGUS), but the association has been uncertain. We investigated the relationship between radiation exposure and MGUS prevalence by using data from the M-protein screening for Nagasaki atomic bomb survivors between 1988 and 2004. Radiation exposure was assessed by exposure distance from the hypocenter and exposure radiation dose. We computed prevalence ratios (PRs) and the 95% confidence intervals (CIs) adjusting for exposure age and sex. A total of 1082 cases of MGUS were identified from 52 525 participants. MGUS prevalence was significantly higher in people exposed at distance within 1.5 km than beyond 3.0 km (PR, 1.4; 95% CI, 1.1-1.9) among those exposed at age 20 years or younger, but it was not found among those exposed at age 20 years or older. MGUS prevalence was also significantly higher in people exposed to more than 0.1 Gy than those exposed to less than 0.01 Gy (PR, 1.7; 95% CI, 1.0-2.8) among those exposed at age 20 years or younger. Thus, people exposed at younger age exhibited a significantly high risk of MGUS when exposed to a high radiation dose. There was no clear association between radiation exposure and the malignant progression of MGUS. Further detailed analysis is needed.
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- 2009
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13. Imatinib provides durable molecular and cytogenetic responses in a practical setting for both newly diagnosed and previously treated chronic myelogenous leukemia: a study in nagasaki prefecture, Japan.
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Matsuo E, Miyazaki Y, Tsutsumi C, Inoue Y, Yamasaki R, Hata T, Fukushima T, Tsushima H, Imanishi D, Imaizumi Y, Iwanaga M, Sakai M, Ando K, Sawayama Y, Ogawa D, Kawaguchi Y, Nagai K, Tsukasaki K, Ikeda S, Moriuchi Y, Yoshida S, Honda M, Taguchi J, Onimaru Y, Tsuchiya T, Tawara M, Atogami S, Yamamura M, Soda H, Yoshida Y, Matsuo Y, Nonaka H, Joh T, Takasaki Y, Kawasaki C, Momita S, Jinnai I, Kuriyama K, and Tomonaga M
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- Adolescent, Adult, Aged, Antineoplastic Agents adverse effects, Benzamides, Creatine Kinase blood, Cytogenetic Analysis, Disease-Free Survival, Exanthema chemically induced, Female, Follow-Up Studies, Humans, Imatinib Mesylate, Japan, Leukemia, Myelogenous, Chronic, BCR-ABL Positive blood, Leukemia, Myelogenous, Chronic, BCR-ABL Positive diagnosis, Leukemia, Myelogenous, Chronic, BCR-ABL Positive genetics, Leukemia, Myelogenous, Chronic, BCR-ABL Positive mortality, Male, Middle Aged, Piperazines adverse effects, Pyrimidines adverse effects, Remission Induction, Antineoplastic Agents administration & dosage, Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy, Piperazines administration & dosage, Pyrimidines administration & dosage
- Abstract
To evaluate the efficacy of imatinib in a practical setting, we registered 43 patients with newly diagnosed chronic myelogenous leukemia (CML) (group I) and 56 patients with previously diagnosed CML (group II) at 11 hematology centers in Nagasaki prefecture, Japan, from December 2001 to July 2005 and analyzed the molecular responses. Cytopenia, fluid retention, and skin rash were major adverse events, along with elevation in creatine phosphokinase levels. With a follow-up of approximately 3.5 years, imatinib treatment led to 88.7% overall survival (OS) and 85.2% progression-free survival (PFS) rates for group I, and 79.8% OS and 76.6% PFS rates for group II; the rates were not significantly different despite a lower average imatinib dose in group II. The rates of complete cytogenetic response at 30 months and major molecular response at 24 months were 86.1% and 62.5%, respectively, in group I, and 77.9% and 58.3% in group II; the rates were not significantly different. As has been reported by other groups, these results demonstrate that imatinib treatment can provide excellent clinical and molecular effects for not only newly diagnosed but also previously treated CML patients in practical settings that cover a wider variety of patients than clinical trials.
- Published
- 2007
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14. Jejunal perforation in a patient with adult T-cell leukemia.
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Isomoto H, Ohnita K, Haraguchi M, Mizuta Y, Momita S, Ikeda S, Omagari K, Murase K, Nakayama T, Maeda T, Murata I, and Kohno S
- Subjects
- Adult, Cytomegalovirus Infections complications, Female, Humans, Intestinal Perforation etiology, Jejunal Diseases etiology, Leukemia-Lymphoma, Adult T-Cell complications
- Abstract
We present a case of adult T-cell leukemia (ATL) with jejunal perforation at the site of intestinal involvement by ATL. A 39-year-old woman presented with sudden-onset abdominal pain. Physical examination showed generalized severe abdominal tenderness and intraabdominal free air was seen on radiographic examination. Under a diagnosis of peritonitis due to intestinal perforation, an emergency operation was performed. A pinhole-like perforation was found in the jejunum 80 cm distal to Treitz's ligament, and the patient underwent partial resection of the affected jejunum. Microscopic examination revealed diffuse infiltration of abnormal lymphocytes into the entire wall of the jejunum and mesenteric lymph nodes. A diagnosis of ATL was confirmed by the presence of antibody to human T-lymphotropic virus type 1 (HTLV-1) in the serum, a positive result for T-cell markers and the HTLV-1 proviral genome in the mononuclear cells in the specimens. The final diagnosis was thus lymphoma subtype of ATL. Combination chemotherapy was repeated until the patient died 14 months postoperatively. Emergent surgery followed by intense chemotherapy might improve survival in patients with ATL and perforated intestine.
- Published
- 2001
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15. De novo acute myeloid leukemia in the elderly; a consistent fraction of long-term survivors by standard-dose chemotherapy.
- Author
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Yoshida S, Kuriyama K, Miyazaki Y, Taguchi J, Fukushima T, Honda M, Hayashibara T, Nagai K, Atogami S, Toriya K, Soda H, Nonaka H, Momita S, Jinnai I, Amenomori T, Kusano M, Yoshida Y, Ikeda S, Matsuo T, and Tomonaga M
- Subjects
- Acute Disease, Aged, Aged, 80 and over, Cytarabine administration & dosage, Daunorubicin administration & dosage, Female, Humans, Karyotyping, Leukemia, Myeloid classification, Leukemia, Myeloid genetics, Leukemia, Myeloid mortality, Male, Mercaptopurine administration & dosage, Middle Aged, Prognosis, Treatment Outcome, Tretinoin administration & dosage, Aging pathology, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Leukemia, Myeloid drug therapy
- Abstract
To clarify the characteristics of de novo acute myeloid leukemia (AML) among the elderly, we reviewed 112 patients over 60 years old (median age 72 years) who were treated at hospitals in Nagasaki Prefecture with a population of 1.5 million between 1987 and 1994. Reclassification of morphological diagnosis revealed that the proportion of M3 was lower but that of M6 and the incidence of cases with trilineage dysplasia (TLD), known as poor prognostic features, were higher in the elderly than in patients less than 60 years old. Similarly, chromosomal data showed a lower frequency of favorable karyotypes such as t(8;21) and t(15;17) in the elderly. The overall survival of all 112 patients was 10.3% at 5 years. Multivariate analysis indicated that good performance status (PS), low WBC at diagnosis, standard dose multi-drug chemotherapy and all-trans retinoic acid (ATRA) treatment for M3 patients, and morphological findings without TLD were significantly correlated with longer survival. Most of the long-term survivors were found among those who received standard dose therapy in this series, although no consensus has been established how to treat elderly AML patients. We propose that a prospective controlled trial is necessary to confirm the role of standard dose chemotherapy for elderly patients with de novo AML.
- Published
- 2001
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16. Circulating interleukin-6 levels are elevated in adult T-cell leukaemia/lymphoma patients and correlate with adverse clinical features and survival.
- Author
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Yamamura M, Yamada Y, Momita S, Kamihira S, and Tomonaga M
- Subjects
- Adult, Enzyme-Linked Immunosorbent Assay, Humans, Leukemia-Lymphoma, Adult T-Cell complications, Prognosis, Survival Analysis, Tumor Cells, Cultured, Interleukin-6 blood, Leukemia-Lymphoma, Adult T-Cell blood
- Abstract
We measured the circulating levels of interleukin (IL)-6 in adult T-cell leukaemia/lymphoma (ATL) patients using an enzyme-linked immunosorbent assay. The IL-6 levels in 59 ATL patients (median 8.2 pg/ml; range < 1.0 to 185.7 pg/ml) were significantly higher than in 30 healthy controls (median < 1.0 pg/ml; range < 1.0 to 3.5 pg/ml) (P < 0.0001) or 32 human T-lymphotropic virus type-I (HTLV-I) carriers (median 4.2 pg/ml: range < 1.0 to 13.3 pg/ml) (P = 0.002). Among the ATL patients, the IL-6 levels in the acute- or lymphoma-type patients were significantly higher than those in the chronic-type patients (P < 0.0001). The IL-6 levels were also higher in the patients with B symptoms than in those without B symptoms (P = 0.039), and were significantly correlated with increased serum lactate dehydrogenase (LDH) (P = 0.0004) and C-reactive protein (CRP) (P < 0.0001) and decreased serum albumin (P = 0.0003) values. The patients with elevated IL-6 levels had inferior overall survival periods compared to those with normal IL-6 levels (P = 0.025). ATL is a single disease entity, although its clinical features are quite diverse; the increased production of cytokines may cause the diversity of clinical features. The results of our study indicate that IL-6 is one such cytokine.
- Published
- 1998
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17. Integration patterns of HTLV-I provirus in relation to the clinical course of ATL: frequent clonal change at crisis from indolent disease.
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Tsukasaki K, Tsushima H, Yamamura M, Hata T, Murata K, Maeda T, Atogami S, Sohda H, Momita S, Ideda S, Katamine S, Yamada Y, Kamihira S, and Tomonaga M
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- Aged, Blotting, Southern, Clone Cells pathology, Clone Cells virology, DNA, Viral analysis, Female, Humans, Leukemia-Lymphoma, Adult T-Cell etiology, Male, Middle Aged, Receptors, Antigen, T-Cell, alpha-beta genetics, Human T-lymphotropic virus 1 genetics, Leukemia-Lymphoma, Adult T-Cell pathology, Leukemia-Lymphoma, Adult T-Cell virology, Proviruses genetics, Virus Integration
- Abstract
We examined human T-lymphotropic virus type I (HTLV-I) DNA integration in 68 patients with adult T-cell leukemia/ lymphoma (ATL) by Southern blotting using EcoRI, which does not cut within the 9 kb of the genome and probes for pX and gag-pol region of HTLV-I. We detected defective proviral integration as a monoclonal band of various sizes with the pX but not with the gag-pol probe, or a monoclonal band of less than 9 kb with the pX probe, in 20 patients (29.4%). These were designated defective (D) type. With both probes, a single band greater than 9 kb was detected in 34 (50.0%), designated complete (C) type, and two or more bands greater than 9 kb, were designated multiple (M) type, in 14 (20.6%). Advanced age, a high LDH value, and hypercalcemia were more frequent in D type patients. The median survival time (MST) was 6.8, 24.4, and 33.3 months, for D, C, and M types, respectively (log rank P = .006). Among 52 sequentially examined patients, the HTLV-I integration patterns changed in 4 (7.5%). In three of these four, the rearrangements of the T-cell receptor (TCR)b gene concomitantly changed, suggesting the appearance of a new ATL clone. Another patient had the same rearrangement of the TCRb gene, indicating clonal evolution. The HTLV-I integration pattern changed at crisis from indolent to aggressive ATL in three patients. These findings suggested that the HTLV-I integration patterns have clinical implications in ATL pathophysiology. In contrast to the clonal evolution characteristic of the multistep carcinogenesis of most human malignancies, the frequent clonal change of ATL at crisis is a peculiar phenomenon, probably reflecting the emergence of multiple premalignant clones in viral leukemogenesis as suggested in Epstein-Barr virus associated lymphomagenesis in the immunocompromised host.
- Published
- 1997
18. Increased levels of interleukin-6 (IL-6) in serum and spontaneous in vitro production of IL-6 by lymph node mononuclear cells of patients with angio-immunoblastic lymphadenopathy with dysproteinemia (AILD), and clinical effectiveness of cyclosporin A.
- Author
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Yamamura M, Honda M, Yamada Y, Itoyama T, Sohda H, Yubashi T, Momita S, Kamihira S, Ohmoto Y, and Tomonaga M
- Subjects
- Aged, Blood Protein Disorders blood, Blood Protein Disorders metabolism, Humans, Immunoblastic Lymphadenopathy blood, Interleukin-6 physiology, Lymph Nodes metabolism, Lymphoma, T-Cell blood, Lymphoma, T-Cell drug therapy, Lymphoma, T-Cell metabolism, Male, Middle Aged, Blood Protein Disorders drug therapy, Cyclosporine therapeutic use, Immunoblastic Lymphadenopathy drug therapy, Immunoblastic Lymphadenopathy metabolism, Immunosuppressive Agents therapeutic use, Interleukin-6 biosynthesis, Interleukin-6 blood, Leukocytes, Mononuclear metabolism, Lymph Nodes cytology
- Abstract
Serum levels of cytokines and in vitro cytokine production by lymph node mononuclear cells (LNMC) were studied in four patients with angio-immunoblastic lymphadenopathy with dysproteinemia (AILD) or AILD-type T cell lymphoma. An increased level of serum interleukin-6 (IL-6) was detected on initial diagnosis in both of two patients examined. Spontaneous production of IL-6 by LNMC was detected in all four patients studied. Immunosuppressive therapy with cyclosporin A (CsA) was attempted in a 68-year-old man, who was refractory to intensive combination chemotherapy. The increased level of IL-6 in this patient decreased to normal within 3 weeks of CsA administration and the patient became symptom-free. One and a half months later, the IL-6 level gradually increased along with clinical exacerbation. We also measured serum levels of IL-1 alpha, IL-2, IL-4, IFN-alpha, gamma and TNF-alpha in parallel with IL-6, but these factors were only sporadically detected. IL-6 production by LNMC was stimulated by IL-2 but inhibited by CsA. These observations suggest that IL-6 is one of the important cytokines to be involved in the pathophysiology of AILD and CsA is a useful reagent for relieving symptoms.
- Published
- 1996
19. Plasma M-CSF as an indicator of response to chemotherapy in adult T cell leukemia patients.
- Author
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Yamada Y, Ohmoto Y, Yamamura M, Murata K, Tsukasaki K, Jo T, Momita S, Kohno T, Hata T, Kamihira S, and Tomonaga M
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- Adult, Aged, Biomarkers blood, Disease Progression, Disease-Free Survival, Female, Humans, Macrophage Colony-Stimulating Factor biosynthesis, Male, Middle Aged, Tumor Cells, Cultured, Macrophage Colony-Stimulating Factor blood, Precursor Cell Lymphoblastic Leukemia-Lymphoma blood, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
- Abstract
The plasma concentration of macrophage colony-stimulating factor (M-CSF) was measured in 10 patients with acute type adult T cell leukemia (ATL) during the clinical course before and after chemotherapy. M-CSF concentration decreased significantly when the patients achieved complete remission (CR) or partial remission (PR) (t-test: p = 0.0001). Five of the patients showed disease progression after several months of PR, and plasma M-CSF increased at that time (t-test: p = 0.0456). Thus, plasma M-CSF concentration appeared to accurately reflect the disease activity in ATL. In support of these results, all three ATL cell lines established from these patients secreted M-CSF in vitro after stimulation with phorbol myristate acetate (PMA) or concanavalin A (Con A). Plasma M-CSF concentration, however, increased transiently when the patients were febrile (t-test: p = 0.0001), even though their ATL condition was unchanged. Taken together, these results indicate that there are two sources of increased plasma M-CSF concentration in ATL; ATL cells themselves and normal parenchymal cells that cause this increase as the result of elevated body temperature due to inflammation.
- Published
- 1996
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20. An intensive chemotherapy of adult T-cell leukemia/lymphoma: CHOP followed by etoposide, vindesine, ranimustine, and mitoxantrone with granulocyte colony-stimulating factor support.
- Author
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Taguchi H, Kinoshita KI, Takatsuki K, Tomonaga M, Araki K, Arima N, Ikeda S, Uozumi K, Kohno H, Kawano F, Kikuchi H, Takahashi H, Tamura K, Chiyoda S, Tsuda H, Nishimura H, Hosokawa T, Matsuzaki H, Momita S, Yamada O, and Miyoshi I
- Subjects
- Adult, Aged, Antineoplastic Combined Chemotherapy Protocols adverse effects, Blood Cell Count, Bone Marrow drug effects, Cyclophosphamide administration & dosage, Doxorubicin administration & dosage, Etoposide administration & dosage, Female, Humans, Leukemia-Lymphoma, Adult T-Cell blood, Leukemia-Lymphoma, Adult T-Cell physiopathology, Male, Middle Aged, Mitoxantrone administration & dosage, Nitrosourea Compounds administration & dosage, Prednisone administration & dosage, Vincristine administration & dosage, Vindesine administration & dosage, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Granulocyte Colony-Stimulating Factor administration & dosage, Leukemia-Lymphoma, Adult T-Cell drug therapy
- Abstract
Summary: An intensive combination chemotherapy regimen supported by granulocyte colony-stimulating factor (G-CSF) was evaluated in adult T-cell leukemia/lymphoma (ATLL) patients in a multiinstitutional, cooperative study. Vincristine 1 mg/m2 i.v. day 1, Adriamycin 40 mg/m2 i.v. day 1, cyclophosphamide 400 mg/m2 i.v. day 1, prednisolone 40 mg/m2 i.v. days 1 to 3 and 8 to 10, etoposide 35 mg/m2 i.v. days 1 to 8, vindesine 2 mg/m2 i.v. day 8, ranimustine 50 mg/m2 i.v. day 8, mitoxantrone 7 mg/m2 i.v. day 8, and G-CSF 50 mg/m2 s.c. days 9 to 21 were given for 2 to 4 courses every 3 weeks to 83 patients with ATLL. Complete remission (CR) and partial remission (PR) were achieved in 35.8 and 38.3 percent, respectively, of 81 evaluable patients. The median survival of all patients was 8.5 months, with a predicted 3-year survival of 13.5 percent by the Kaplan-Meier method. The median duration of response was 7.6 months (range 0.2-42.7), and 13 patients were alive. Their median survival time was 29.1 months (range 19.2-44.7). In 67.6 percent of courses, white blood cell (WBC) nadirs were < 1.0 x 10(9)/L. Days required for the recovery of WBC from the nadir to > 1.0 x 10(9)/L were <5 days in 71.4 percent of the treatment courses. The G-CSF supported an intensified chemotherapy regimen for ATLL and yielded better response rate and longer survival compared to previous reports in Japan. Because duration of remission is still short, further studies of postremission therapy or other strategies are warranted.
- Published
- 1996
- Full Text
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21. Molecular detection of pre-ATL state among healthy HTLV-1 carriers in an endemic area of Japan.
- Author
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Chen YX, Ikeda S, Mori H, Hata T, Tsukasaki K, Momita S, Yamada Y, Kamihira S, Mine M, and Tomonaga M
- Subjects
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, DNA, Viral analysis, Female, Human T-lymphotropic virus 1 genetics, Humans, Japan epidemiology, Male, Middle Aged, Preleukemia virology, Human T-lymphotropic virus 1 isolation & purification, Leukemia-Lymphoma, Adult T-Cell epidemiology, Preleukemia diagnosis
- Abstract
Adult T-cell leukemia/lymphoma (ATL) usually develops after age 40 in Japan, suggesting a long latency since HTLV-I is considered to be transmitted mainly from mothers to babies via breast milk. Our previous studies had suggested that HTLV-I carriers who have a monoclonal integration of HTLV-I proviral DNA in the peripheral blood cells, designated pre-ATL, account for about 2% of healthy carriers and are at high risk of developing ATL. Their ages ranged from 32 to 80 (median 57). Nevertheless, many cases of pre-ATL showed a long-lasting carrier state (10-year probability around 90%). In the present investigation we conducted a large-scale molecular detection of monoclonal integration in a population (481 cases) of healthy carriers with ages ranging from 16 to 82 (median 49) for the purpose of clarifying the earliest onset of this pre-ATL state. Southern-blot analysis of DNA extracted from peripheral blood mononuclear cells revealed 6 cases (1.2%) with a monoclonal band. All of these 6 were older than 40; no single positive case was found in 220 carriers under age 40. These results indicate that the molecularly detectable pre-ATL state also develops after a long latency. Thus the pre-ATL state seems to be a subtype of ATL showing an extremely indolent course of disease development, but not merely an early phase of all subtypes of ATL. We propose that, in order to reveal a promoter(s) responsible for the development of ATL from the pre-ATL state, intensive epidemiological investigation of life style, eating habits, occupation and exposure to carcinogens must be conducted on this unique group prone to ATL. It is also important to perform such an epidemiological study on the general population of carriers by paying special attention to the first 3-4 decades of each carrier's life in Japan and by comparing the data with those from carriers in different geographical areas of the world.
- Published
- 1995
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22. [Clinical characteristics and poor outcomes in patients with de novo AML with trilineage myelodysplasia].
- Author
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Arimura K, Kuriyama K, Miyazaki Y, Nagai K, Fukushima T, Yoshida S, Moriuchi Y, Momita S, and Tomonaga M
- Subjects
- Adolescent, Adult, Aged, Female, Humans, Leukemia, Myeloid, Acute mortality, Male, Middle Aged, Treatment Outcome, Leukemia, Myeloid, Acute pathology, Leukemia, Myeloid, Acute therapy, Myelodysplastic Syndromes complications
- Abstract
De novo AML with trilineage myelodysplasia (AML/TMDS) is reported to account for 10-15% of de novo AML and respond poorly to conventional intensive chemotherapy, In our series, 12 (25%) of 48 patients with de novo AML were diagnosed as AML/TMDS. We found that the platelet count was significantly higher (p < 0.05), and the blast percentage of the bone marrow was significantly lower (p < 0.05) in the AML/TMDS group than in the AML/non-TMDS group. Sex ratio, age, WBC and RBC count did not significantly differ between the two groups. The immunological markers and the myeloperoxidase positivity of the blasts of AML/TMDS varied widely. The CR rate was 66.7% in the AML/TMDS group and 83.3% in the AML/non-TMDS group. Dysplastic changes were still detected in the bone marrow smears in 7 of 8 AML/TMDS cases who achieved complete remission. The AML/TMDS group showed significantly shorter CR duration (median; 169 days) and survival (median; 511 days, p < 0.05). However, in two cases which underwent allogeneic bone marrow transplantation (allo-BMT) during early relapse phase the disease-free survival has extended over 4 years and 2 years 8 months, respectively. Thus, we would like to propose that allo-BMT should be performed as early as possible to overcome poor outcome of AML/TMDS.
- Published
- 1995
23. Established IL-2-dependent double-negative (CD4- CD8-) TCR alpha beta/CD3+ ATL cells: induction of CD4 expression.
- Author
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Yamada Y, Fujita M, Suzuki H, Atogami S, Sohda H, Murata K, Tsukasaki K, Momita S, Kohno T, and Maeda T
- Subjects
- Benzoquinones, Blotting, Northern, Blotting, Southern, CD4 Antigens drug effects, CD4 Antigens genetics, CD8 Antigens blood, Concanavalin A pharmacology, Female, Gene Expression, Gene Rearrangement, beta-Chain T-Cell Antigen Receptor immunology, Humans, Lactams, Macrocyclic, Leukemia, T-Cell blood, Middle Aged, Protein-Tyrosine Kinases antagonists & inhibitors, Quinones pharmacology, RNA, Messenger analysis, Rifabutin analogs & derivatives, T-Lymphocyte Subsets immunology, Tumor Cells, Cultured, CD3 Complex blood, CD4 Antigens biosynthesis, Interleukin-2 immunology, Leukemia, T-Cell immunology, Receptors, Antigen, T-Cell, alpha-beta analysis
- Abstract
We established IL-2-dependent T cells from an adult T-cell leukaemia (ATL) patient whose leukaemic cells changed from CD4 single-positive in the initial phase to double-negative (CD4- CD8-) at the time of exacerbation. The cells termed SO-4 were of ATL cell origin and showed the double-negative TCR alpha beta/CD3+ T-cell phenotype. SO-4 cells acquired CD4 antigen expression following stimulation with concanavalin A (ConA) or immobilized anti-CD3 antibody. The induction was inhibited by herbimycin A, an inhibitor of protein tyrosine kinase (PTK) activity. No CD4 mRNA was detectable in unstimulated SO-4 cells but a 3.0 kb signal specific for CD4 mRNA was detected after stimulation. These findings indicate that SO-4 cells return to their original phenotype (CD4 single-positive) by stimulation involving PTK. The results indicate that there is a pathway of phenotypic cycling between CD4 single-positive and double-negative T cells.
- Published
- 1994
- Full Text
- View/download PDF
24. Increased plasma M-CSF concentration in patients with adult T cell leukemia: clinical correlation.
- Author
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Yamada Y, Ohmoto Y, Murata K, Tsukasaki K, Momita S, Kamihira S, Atogami S, Sohda H, Moriuchi Y, and Itoyama T
- Subjects
- Adult, Anemia, Refractory, with Excess of Blasts blood, Biomarkers, Tumor blood, C-Reactive Protein analysis, Chronic Disease, Cytokines blood, Humans, L-Lactate Dehydrogenase blood, Leukemia-Lymphoma, Adult T-Cell classification, Neoplasm Proteins blood, Preleukemia blood, Leukemia-Lymphoma, Adult T-Cell blood, Macrophage Colony-Stimulating Factor blood
- Abstract
Plasma concentration of M-CSF was measured in 35 patients with adult T cell leukemia (ATL), using a radioimmunoassay (RIA). ATL patients showed elevated levels of plasma M-CSF concentration when compared with healthy adult volunteers. Higher M-CSF levels were observed in acute ATL patients than in patients with chronic or smouldering ATL (P < 0.0001). There was a significant positive correlation of M-CSF concentration with serum lactic dehydrogenase (LDL) level, a reliable marker for assessing the grade of malignancy in ATL (P = 0.0003). There was, however, no correlation of M-CSF concentration with total counts of peripheral blood ATL cells, neutrophils or monocytes, or with serum calcium levels. Although there was a significant positive correlation of M-CSF concentration with body temperature (P = 0.003), there was not a significant correlation of M-CSF concentration with C-reactive protein (CRP), a protein indicative of the severity of inflammation (P = 0.063). These results indicate that plasma M-CSF concentration reflects the disease activity of ATL, and can thus serve as a marker in the clinical subclassification of ATL patients.
- Published
- 1994
- Full Text
- View/download PDF
25. Characteristics of chemotherapy-induced clinical remission in long survivors with aggressive adult T-cell leukemia/lymphoma.
- Author
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Tsukasaki K, Ikeda S, Murata K, Maeda T, Atogami S, Sohda H, Momita S, Jubashi T, Yamada Y, and Mine M
- Subjects
- Adult, Antineoplastic Agents administration & dosage, CD4-CD8 Ratio, DNA, Viral genetics, Female, Human T-lymphotropic virus 1 genetics, Humans, L-Lactate Dehydrogenase blood, Leukemia-Lymphoma, Adult T-Cell classification, Leukemia-Lymphoma, Adult T-Cell microbiology, Leukemia-Lymphoma, Adult T-Cell physiopathology, Leukocyte Count, Male, Survival Analysis, Virus Integration, Leukemia-Lymphoma, Adult T-Cell drug therapy
- Abstract
The acute and lymphoma types of adult T-cell leukemia/lymphoma (ATL) usually have a very poor prognosis, although some patients achieve long survival after chemotherapy. A total of 114 patients with these aggressive types of ATL were newly diagnosed at our institution from 1975 to 1989. By multivariate analysis, poor performance status and high serum creatine levels were associated with shortened survival. With combination chemotherapy, 20 patients achieved complete remission (CR), 53 achieved partial remission (PR) and 35 showed no response. Fifteen of the CR or PR patients survived for more than two years and all other patients survived for less than two years. As compared with short survivors (< 2 years) after remission, long survivors (> or = 2 years) after remission had a higher CR/PR ratio, a longer time until remission and a higher doxorubicin dose to achieve remission. Death due to causes other than the primary disease occurred in 18% of short survivors after remission and in 11.2% of nonresponders, but in none of the long survivors. Long survivors with acute ATL included 6 patients with CR and 5 patients with PR. All four lymphoma type ATL long survivors achieved CR. Monoclonal integration of HTLV-I provirus was detected in the peripheral blood mononuclear cells of all 3 PR long survivors with acute ATL studied, but was not detected in all 4 CR cases studied at remission. The minimum CD4/CD8 ratio of peripheral mononuclear cells at remission was < 1.0 in all acute ATL long survivors with CR, and was > 1.0 in all acute ATL long survivors with PR. Three out of six acute ATL long survivors with CR developed suspected viral infection just before achieving CR. Our findings show that in aggressive ATL the characteristics of remission are heterogeneous even among long survivors.
- Published
- 1993
- Full Text
- View/download PDF
26. Effects of short-term liquid cultures of peripheral blood mononuclear cells with recombinant human granulocyte or granulocyte-macrophage colony-stimulating factor in cytogenetic studies of myelofibrosis with myeloid metaplasia.
- Author
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Nakamura H, Sadamori N, Mine M, Kawachi T, Itoyama T, Sasagawa I, Moriuchi Y, Momita S, Nonaka H, and Matsuo T
- Subjects
- Aged, Cells, Cultured, Female, Humans, Karyotyping, Leukocytes, Mononuclear drug effects, Leukocytes, Mononuclear pathology, Male, Middle Aged, Mitosis drug effects, Primary Myelofibrosis complications, Primary Myelofibrosis genetics, Recombinant Proteins pharmacology, Cytological Techniques, Granulocyte Colony-Stimulating Factor pharmacology, Granulocyte-Macrophage Colony-Stimulating Factor pharmacology, Primary Myelofibrosis pathology
- Published
- 1992
27. A case of beta-thalassemia with a C----T substitution at position 654 of the second intervening sequence of the beta-globin gene.
- Author
-
Jo T, Momita S, Sadamori N, Tomonaga M, Fucharoem S, Fukumaki Y, and Ichimaru M
- Subjects
- Adult, Base Sequence, DNA genetics, DNA Mutational Analysis, Female, Glomerulonephritis, IGA complications, Humans, Introns, Molecular Sequence Data, Pedigree, RNA Splicing genetics, RNA, Messenger genetics, Thalassemia complications, Globins genetics, Thalassemia genetics
- Abstract
A 26-year-old Chinese-Malaysian female patient with beta-thalassemia is presented. The main hematological values found in this patient were as follows: 1) normocytic hypochromic anemia (RBC 444 x 10(4)/microliters, Hb 11.8 g/dl) with marked anisopoikilocytosis, 2) erythroid hyperplasia, and 3) increased HbF (HbA 41.4%, HbA2 2.9%, HbF 48.9%). DNA obtained from peripheral leukocytes was analyzed using dot blot hybridization of the polymerase chain reaction (PCR)-amplified DNA with allele-specific oligonucleotide probes. A C----T substitution at position 654 of the second intervening sequence (IVS-2) was detected in her beta-globin clone.
- Published
- 1992
- Full Text
- View/download PDF
28. Phenotypic diversity and prognosis of adult T-cell leukemia.
- Author
-
Kamihira S, Sohda H, Atogami S, Toriya K, Yamada Y, Tsukazaki K, Momita S, Ikeda S, Kusano M, and Amagasaki T
- Subjects
- CD4 Antigens analysis, CD8 Antigens analysis, Female, HTLV-I Antibodies analysis, Humans, Immunophenotyping, Leukemia, T-Cell immunology, Leukemia, T-Cell mortality, Male, Phenotype, Prognosis, Antigens, CD analysis, Leukemia, T-Cell pathology
- Abstract
We examined phenotypically 107 patients with adult T-cell leukemia (ATL), using a panel of monoclonal antibodies, in order to clarify the occurrence of aberrant phenotypes, and to determine the correlation between phenotypic diversity and prognosis. The incidence of the typical (CD4+.CD8-) phenotype, the double-negative (CD4-.CD8-), the double-positive (CD4+.CD8+), and the CD8-positive (CD4-.CD8+) phenotypes was 81%, 7%, 7%, and 4%, respectively. The median survival time (MST) for all patients was 10.0 months with 17% survival at 2 years. The patients with typical phenotypes had a 10.2 month MST with 20% survival at 2 years, significantly better than the patients with the unusual phenotypes whose MST were 4.9, 7.8, and 2.6 months, respectively, for the double-negative, double-positive, and CD8-positive phenotypes. Lack of antigens reactive with CD2, CD3, CD5, and WT31 monoclonal antibody panels was one factor in bad prognosis, but the presence of CD4 and CD8 antigen abnormalities was much more significant.
- Published
- 1992
- Full Text
- View/download PDF
29. Cohort study of hepatotropic virus and human T lymphotropic virus type-I infections in an area endemic for adult T cell leukemia.
- Author
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Kamihira S, Momita S, Ikeda S, Yamada Y, Sohda H, Atogami S, Tomonaga M, Kinoshita K, Toriya K, and Furukawa R
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Hepatocellular etiology, Carcinoma, Hepatocellular microbiology, Cohort Studies, Female, HTLV-I Infections complications, Hepatitis B complications, Hepatitis C complications, Humans, Japan epidemiology, Leukemia, T-Cell epidemiology, Leukemia, T-Cell etiology, Leukemia, T-Cell microbiology, Liver Neoplasms etiology, Liver Neoplasms microbiology, Male, Middle Aged, HTLV-I Infections epidemiology, Hepatitis B epidemiology, Hepatitis C epidemiology
- Abstract
We tested for antibodies to hepatitis B virus (HBV), hepatitis C virus (HCV), and human T lymphotropic virus type-I (HTLV-I) in 629 normal inhabitants of an adult T cell leukemia (ATL) endemic area and in patients with ATL, HTLV-I associated myelopathy (HAM), and hepatocellular carcinoma (HCC) from the same district. The prevalence of serological positivity for each virus was 28.0, 6.4, and 32.6%, respectively, among the 629 inhabitants. There was a positive association between the presence of anti-HCV and serological HTLV-I positive or negative status of these subjects (9.3% vs 5.0%). Conversely, there was no correlation between HBV and HTLV-I serologic prevalence. Only inhabitants positive for anti-HCV showed significantly high serum aminotransferase levels. The levels were not affected by superimposed HTLV-I infection among anti-HCV positives. Fifty three percent of HCC patients were positive for anti-HCV; 35% of whom were simultaneously positive for antibody to HTLV-I. On the other hand, only 2 ATL patients (4.2%) and 2 HAM patients (7.7%) had anti-HCV. These findings suggest that high serum aminotransferase levels are mainly caused by HCV infection and persons with HCV and HTLV-I double infections are at a high risk for the development of HCC but not ATL or HAM.
- Published
- 1991
- Full Text
- View/download PDF
30. Prognostic significance of the proportion of Ki-67-positive cells in adult T-cell leukemia.
- Author
-
Yamada Y, Murata K, Kamihira S, Atogami S, Tsukasaki K, Sohda H, Yanagisako T, Momita S, Jubashi T, and Amagasaki T
- Subjects
- Humans, Ki-67 Antigen, L-Lactate Dehydrogenase blood, Leukemia, T-Cell enzymology, Leukemia, T-Cell mortality, Prognosis, Survival Rate, Antigens, Neoplasm analysis, Leukemia, T-Cell immunology, Nuclear Proteins analysis
- Abstract
The authors examined peripheral blood samples from patients with adult T-cell leukemia (ATL) using the monoclonal antibody Ki-67 which detects a nuclear antigen present in actively proliferating cells. In patients with chronic ATL, the percentage of Ki-67-positive cells was significantly lower than in acute ATL patients (median values, 3.3% versus 18.9%, P less than 0.001). Furthermore, there was a significant inverse correlation between the percentage of Ki-67-positive cells and the length of survival (P less than 0.001). Serum lactic dehydrogenase (LDH) levels also showed a significant inverse correlation with survival, but this was less strong than that for Ki-67 (0.01 less than P less than 0.02). Thus, Ki-67 positivity appears to indicate the aggressiveness of ATL, and can possibly be used for the clinical classification of ATL patients as well as for the prediction of prognosis.
- Published
- 1991
- Full Text
- View/download PDF
31. Survey of anti-human T-cell leukemia virus type I antibody in family members of patients with adult T-cell leukemia.
- Author
-
Momita S, Ikeda S, Amagasaki T, Soda H, Yamada Y, Kamihira S, Tomonaga M, Kinoshita K, and Ichimaru M
- Subjects
- Adult, Age Factors, Aged, Family, Female, Humans, Leukemia, T-Cell epidemiology, Leukemia, T-Cell immunology, Male, Middle Aged, Pedigree, Sex Factors, HTLV-I Antibodies immunology, Human T-lymphotropic virus 1 immunology, Leukemia, T-Cell microbiology
- Abstract
To evaluate the intrafamilial clustering of HTLV-I, we examined the sera or plasma of 296 healthy family members of patients with adult T-cell leukemia (ATL) for anti-HTLV-I antibodies. Of 296 subjects, 132 (44.6%) had anti-HTLV-I antibodies. Fifty-nine (41.0%) out of 144 males and 73 (48.0%) out of 152 females were seropositive. The positive rates of antibody to HTLV-I increased with age, especially between the 30-39 and the 40-49 age groups. Five out of 6 fathers, 3 out of 4 mothers, 31 (60.8%) out of 51 spouses, 40 (63.5%) out of 63 siblings and 46 (33.8%) out of 136 children of patients with ATL had anti-HTLV-I antibodies. Of 74 children with an ATL father, 14 (18.9%) were seropositive, while 32 (51.6%) out of 63 children with an ATL mother were seropositive. This difference was statistically significant (P less than 0.001). Of those children with an ATL father, 12 (26.1%) out of 46 whose mothers were HTLV-I carriers had antibodies to HTLV-I. In contrast, none of the 13 children whose mothers were not carriers were seropositive. These results supported the hypothesis that the mother-to-child transmission is one of the most important modes of HTLV-I transmission. In wives of male patients with ATL, the positive rate of antibody to HTLV-I was 65.6% (21/32), and in husbands of female patients, it was 52.6% (10/19). The high positive rate of antibody to HTLV-I not only in wives of male patients but also in husbands of female patients suggests that either HTLV-I is more frequently transmitted from wives to their husbands than we had originally expected, or that ATL may develop even in wives who acquire HTLV-I from their husbands after marriage.
- Published
- 1990
- Full Text
- View/download PDF
32. Detection of preleukemic state of adult T-cell leukemia (pre-ATL) in HTLV-1 carriers.
- Author
-
Ikeda S, Momita S, Amagasaki T, Tsukasaki K, Yamada Y, Kusumoto Y, Ito M, Kanda N, Tomonaga M, and Soda H
- Subjects
- Adult, Age Factors, Blotting, Southern, Carrier State transmission, Female, HTLV-I Infections epidemiology, HTLV-I Infections transmission, Human T-lymphotropic virus 1 genetics, Humans, Incidence, Japan epidemiology, Leukemia, T-Cell microbiology, Male, Preleukemia microbiology, HTLV-I Infections complications, Leukemia, T-Cell epidemiology, Preleukemia epidemiology
- Abstract
The prevalence of the preleukemic state of adult T-cell leukemia (pre-ATL) was studied in Nagasaki prefecture, one of the endemic human T-lymphotropic virus type 1 (HTLV-1) areas in Japan. Pre-ATL cases have the monoclonal proliferation of abnormal lymphocytes, without signs of malignant proliferation or clinical signs and symptoms related to leukemia. HTLV-1 carriers who have monoclonal integration of HTLV-1 proviral DNA may be at high risk of developing ATL. Abnormal lymphocytes with either bilobular or large and chromatin-rich nuclei were found in 63/356 (17.7%) of HTLV-1 carriers among inhabitants. We analyzed DNA of peripheral lymphocytes from 108 carries with abnormal lymphocytes by Southern blot technique. Monoclonal integration of HTLV-1 has been detected in 12 cases (11.1%). These results lead to the conclusion that the prevalence rate of pre-ATL among all HTLV-1 carriers is about 2%. Pre-ATL is presumed to be the clinical stage which precedes ATL, although the possibility remains that the HTLV-1 carrier may develop symptoms of ATL directly, without going through the pre-ATL stage.
- Published
- 1990
33. [Clinical aspects of adult T-cell leukemia-lymphoma (ATLL). (1) Survival rate and prognosis of adult T-cell leukemia].
- Author
-
Kinoshita K, Ikeda S, Yamada Y, Amagasaki T, Momita S, Toriya K, Ichimaru M, and Kamihira S
- Subjects
- Adult, Aged, Female, Humans, L-Lactate Dehydrogenase blood, Male, Middle Aged, Prognosis, T-Lymphocytes, Leukemia mortality
- Published
- 1983
34. [IgM anti-ATLA antibodies in HTLV-I healthy carriers and patients with adult T cell leukemia and HTLV-I associated myelopathy].
- Author
-
Kamihira S, Sohda H, Momita S, Ikeda S, Moriuti Y, Oyakawa N, Amagasaki T, Yamada Y, Ichimaru M, and Nakamura T
- Subjects
- Deltaretrovirus Antibodies, Humans, Antibodies, Viral analysis, Carrier State immunology, Deltaretrovirus immunology, Deltaretrovirus Infections immunology, Immunoglobulin M analysis
- Published
- 1988
- Full Text
- View/download PDF
35. Adult T-cell leukemia-associated antigen (ATLA) and anti-ATLA antibodies in patients with Hodgkin's disease in the Nagasaki District.
- Author
-
Kinoshita K, Amagasaki T, Yamada Y, Ikeda S, Momita S, Toriya K, Kamihira S, and Ichimaru M
- Subjects
- Female, Humans, Japan, Male, Middle Aged, T-Lymphocytes immunology, Antibodies, Viral analysis, Antigens, Viral analysis, Hodgkin Disease immunology, Leukemia immunology, Lymphoma immunology, Retroviridae immunology
- Abstract
Seven patients with Hodgkin's disease in the Nagasaki district were examined for adult T-cell leukemia-associated antigen (ATLA), a human retrovirus-associated antigen, and anti-ATLA antibodies. Anti-ATLA antibody reactivity with the ATLA-positive cultured cells from an ATL patient was demonstrated in four (57.1%) of seven patients. This suggests that infection by a human retrovirus may be closely associated with Hodgkin's disease in the Nagasaki district. However, ATLA could not be induced in the cultured mononuclear cells taken from biopsied lymph nodes of the three patients examined. Hence, it is necessary to collect more direct evidence in the search for a viral etiology of Hodgkin's disease.
- Published
- 1983
36. [Clinical statistics of adult T-cell leukemia and HTLV carriers].
- Author
-
Ichimaru M, Kamihira S, Yamada Y, Momita S, Amagasaki T, Ikeda S, Kitamura T, and Kinoshita K
- Subjects
- Adult, Female, Humans, Japan, Male, Middle Aged, Antibodies, Viral analysis, Carrier State epidemiology, Deltaretrovirus immunology, Deltaretrovirus Infections epidemiology
- Published
- 1986
37. [Clinical studies of adult T-cell leukemia-lymphoma. (2) Hypercalcemia associated with adult T-cell leukemia].
- Author
-
Kinoshita K, Oyakawa Y, Toriya K, Momita S, Amagasaki T, Yamada Y, Ikeda S, Ichimaru M, and Kamihira S
- Subjects
- Humans, Leukemia pathology, T-Lymphocytes, Hypercalcemia complications, Leukemia complications
- Published
- 1983
38. Milk-borne transmission of HTLV-I from carrier mothers to their children.
- Author
-
Kinoshita K, Amagasaki T, Hino S, Doi H, Yamanouchi K, Ban N, Momita S, Ikeda S, Kamihira S, and Ichimaru M
- Subjects
- Adult, Child, Preschool, Deltaretrovirus, Deltaretrovirus Infections blood, Female, Follow-Up Studies, Humans, Infant, Carrier State, Deltaretrovirus Infections transmission, Milk, Human microbiology
- Abstract
In order to clarify the natural transmission route of human T-cell leukemia virus type I (HTLV-I) from mother to child, we have followed two groups of children with ages of 1 to 3 years who were nourished either with HTLV-I-infected breast milk, or with non-infected milk from sero-positive, HTLV-I carrier mothers. Tests for the presence of antibody against HTLV-I revealed that 4 of 6 children in the former group developed HTLV-I infection, while only 1 of 14 children in the latter group became infected. The difference in HTLV-I infection rate for the children in the two groups was statistically significant (P less than 0.01 by chi-square). Furthermore, 2 of 4 elder siblings in the former group developed HTLV-I infection, whereas only one of 8 elder siblings in the latter group became infected. The overall rate of HTLV-I infection of breast-fed children born to HTLV-I-carrier mothers was 25% (8/32) by 3 years of age. Five of 6 mothers with HTLV-I-infected cells in the milk also possessed infected cells in their peripheral blood. Conversely 5 of 6 mothers without infected cells in the peripheral blood possessed no infected cells in their breast milk, suggesting that HTLV-I-infected cells in the peripheral blood can enter the breast milk. None of the 8 breast-fed children born to carrier mothers whose peripheral blood and breast milk-borne cells were negative, developed HTLV-I infection, suggesting that HTLV-I transmission from mother to child is dependent upon the number of HTLV-I-infected cells in carrier mothers.
- Published
- 1987
39. [Mother to child transmission of human T cell leukemia virus type-1].
- Author
-
Ikeda S, Kinoshita K, Amagasaki T, Momita S, Soda H, Ito M, Kanda T, Tachibana K, Doi H, and Tsuji Y
- Subjects
- Adult, Animals, Breast Feeding, Callitrichinae, Carrier State, Child, Child, Preschool, Female, HTLV-I Antibodies analysis, HTLV-I Infections prevention & control, Humans, Infant, Male, Pregnancy, HTLV-I Infections transmission, Pregnancy Complications, Infectious
- Abstract
Infection of HTLV-1 during childhood may be the most probable cause of leukemogenesis of ATL. The possibility of mother to child transmission of HTLV-1 was studied. Our epidemiological investigation disclosed that almost all mothers of HTLV-1 carrier children were positive for anti-HTLV-1 antibody and children born from carrier mothers showed statistically higher positive rate for anti-HTLV-1 antibody than control groups. A large number of HTLV-1 positive lymphocytes were detected in the milk from carrier mother, but not in the cord blood from newborn babies delivered from carrier mothers. We inoculated the fresh milk collected from carrier mothers into the oral cavity of a common marmoset to prove the oral infection. The marmoset was found to be seroconverted and viral antigen expression was detected in short term cultures of its peripheral T lymphocytes. These results suggest that we can prevent the transmission of HTLV-1 by prohibiting the breast-fed [corrected] by carrier mother. We have so far followed up 55 children born from carrier mothers but fed with compound milk only. None of the children in this group became a carrier of HTLV-1, whereas breast-fed group was found to have higher incidence of sero-positivity for HTLV-1. Therefore the trial prevention of HTLV-1 transmission is now undertaken in Nagasaki district.
- Published
- 1989
40. [Difference of antibody profile for human T-lymphotropic virus type-I (HTLV-I) among individuals].
- Author
-
Kamihira S, Sohda H, Momita S, Amagasaki T, Yamada Y, Ikeda S, Tomonaga M, Ichimaru M, Kinosita K, and Sawada T
- Subjects
- Aged, Female, Humans, Immunoglobulin G analysis, Immunoglobulin M analysis, Leukemia-Lymphoma, Adult T-Cell immunology, Male, Middle Aged, Trans-Activators immunology, HTLV-I Antibodies analysis, HTLV-I Infections immunology
- Abstract
Healthy carriers, patients with ATL and HTLV-I associated myelopathy (HAM) were examined for HTLV-I antibodies of IgG and IgM classes and anti-p 40x antibodies, using ELISA, western blot (WB) and particle agglutination (PA) techniques. IgG antibodies were almost always detectable in sera from all of patients with ATL and HAM and healthy carriers with high titer in the PA test (normal carriers), and the average value of OD 405 was 2.0 +/- 0.3, 1.6 +/- 0.6 and 1.3 +/- 0.7, respectively. In anti-p 40x antibodies, the detectable incidence of HAM, ATL, normal carriers and carriers with low titer of the PA (low-PA group) was 90%, 67%, 44%, and 3%; and, the average value of OD 405 of the antibodies was 2.3 +/- 1.0, 0.7 +/- 0.5, and 0.7 +/- 0.7, respectively. On the other hand, the incidence of IgM antibodies demonstrated in HAM, ATL, normal carriers and low-PA group was 90%, 41%, 33%, and 53%, respectively. Furthermore, the follow-up observation of these antibodies revealed that the antibody profile of individuals for a long time was constant, i.e. in each carrier the value with high OD remained high and the presence of anti-p 40x and/or IgM antibodies remained present. These data has demonstrated that there are considerably differences among individuals in responsivilities for HTLV-I. Then, the antibody profile is mainly classified into 3 groups; hyper-, common- and hypo-immune patterns.
- Published
- 1989
41. [Bacteriological study on autopsy cases with hematological malignancies, particularly the increased isolation of fungus and gram-positive cocci].
- Author
-
Moriuchi Y, Kamihira S, Yamaguchi K, Sasagawa I, Nakamura H, Jubashi T, Nonaka H, Momita S, Jinnai I, and Nishino K
- Subjects
- Bacterial Infections prevention & control, Enterobacter isolation & purification, Humans, Leukemia pathology, Lymphoma pathology, Candida isolation & purification, Leukemia microbiology, Lymphoma microbiology, Pseudomonas isolation & purification, Staphylococcus isolation & purification
- Published
- 1986
42. Demonstration of adult T-cell leukemia virus antigen in milk from three sero-positive mothers.
- Author
-
Kinoshita K, Hino S, Amagaski T, Ikeda S, Yamada Y, Suzuyama J, Momita S, Toriya K, Kamihira S, and Ichimaru M
- Subjects
- Adult, Carrier State, Female, Fluorescent Antibody Technique, Humans, Leukocyte Count, Monocytes microbiology, Retroviridae Infections genetics, Retroviridae Infections transmission, Antigens, Viral analysis, Deltaretrovirus immunology, Milk, Human microbiology
- Abstract
The expression of adult T-cell leukemia virus (ATLV/HTLV) antigen was demonstrated by the indirect immunofluorescence method in phytohemagglutinin-cultured mononuclear cells of milk samples from 3 out of 22 sero-positive mothers after delivery. This result raises the possibility that milk might be the source of ATLV/HTLV infection of infants.
- Published
- 1984
43. [Follow-up of lymphocyte morphology and detection of human T-cell leukemia virus type-I (HTLV-I) proviral DNA in HTLV-I carriers].
- Author
-
Momita S, Amagasaki T, Soda H, Ikeda S, Kamihira S, Kinoshita K, and Ichimaru M
- Subjects
- Adult, Aged, Aged, 80 and over, Antigens, Viral analysis, Female, HIV Antigens, Humans, Male, Middle Aged, Carrier State blood, DNA, Viral analysis, Deltaretrovirus, Deltaretrovirus Infections blood, Lymphocytes pathology
- Published
- 1986
44. [T2 cell malignancy: clinicopathological studies of lymphoma].
- Author
-
Ichimaru M, Kinoshita K, Yamada Y, Ikeda S, Amagasaki T, and Momita S
- Subjects
- Adult, Female, Humans, Leukemia pathology, Male, Middle Aged, Lymphoma pathology, T-Lymphocytes pathology
- Published
- 1983
45. [Effect of combination chemotherapy with cis-dichlorodiammineplatinum on relapsed or therapy-resistant non-Hodgkin's lymphoma].
- Author
-
Tsukasaki K, Ikeda S, Momita S, Nagai K, Murata K, Tokunaga S, Kohno T, Itoyama T, Toriya K, and Kuriyama K
- Subjects
- Adult, Aged, Cisplatin adverse effects, Cyclophosphamide administration & dosage, Doxorubicin administration & dosage, Drug Resistance, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local drug therapy, Prednisolone administration & dosage, Remission Induction, Vincristine administration & dosage, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Cisplatin administration & dosage, Lymphoma, Non-Hodgkin drug therapy
- Published
- 1988
46. [Detection of anti-ATLA (adult T cell leukemia cell associated antigen) antibody in Nagasaki District, ATL-endemic area].
- Author
-
Momita S
- Subjects
- Adult, Aged, Blood Transfusion, Female, Humans, Japan, Kidney Failure, Chronic immunology, Lymphoma immunology, Male, Middle Aged, Retroviridae Infections transmission, T-Lymphocytes, Antibodies, Viral analysis, Deltaretrovirus immunology, Leukemia immunology
- Published
- 1984
47. [The pathophysiology of malignant lymphoma from the hematological point of view. 3. Changes in peripheral blood lymphocyte count and the recovery of cell-mediated immune function after therapy of T-, B-malignant lymphomas and Hodgkin's disease].
- Author
-
Kinoshita K, Amagasaki T, Momita S, Ikeda S, Ichimaru M, and Kamihira S
- Subjects
- Hodgkin Disease therapy, Humans, Immunity, Cellular, Leukocyte Count, Lymphocytes, Lymphoma therapy, Hodgkin Disease immunology, Lymphoma immunology
- Published
- 1986
48. Adult T-cell leukemia-lymphoma-related diseases in the Nagasaki District.
- Author
-
Kinoshita K, Amagasaki T, Yamada Y, Ikeda S, Momita S, Toriya K, Kamihira S, and Ichimaru M
- Subjects
- Aged, Antibodies, Viral analysis, Antigens, Surface analysis, Antigens, Viral analysis, Female, Humans, Japan, Leukemia immunology, Lymphocytosis immunology, Lymphoma immunology, Male, Middle Aged, Retroviridae immunology, Skin Neoplasms immunology, T-Lymphocytes immunology, T-Lymphocytes pathology, Leukemia pathology, Lymphocytosis pathology, Lymphoma pathology, Skin Neoplasms pathology
- Abstract
The clinical, hematological and pathological features of the adult T-cell leukemia (ATL)-related diseases and their cell membrane phenotypes in the Nagasaki district, one of the ATL-endemic areas, were delineated to compare them with those of adult T-cell leukemia-lymphoma (ATLL). In addition, the participation of ATL virus (ATLV) in the ATL-related diseases was investigated on the basis of a study of ATLV-associated antigen (ATLA) and anti-ATLA antibody. ATLA and/or anti-ATLA antibody could be detected in the ATL-related diseases, including persistent T-lymphocytosis with morphologically abnormal T-lymphocytes, T-cell chronic lymphocytic leukemia (T-CLL) of helper T-cells, T-cell malignant lymphoma of the skin, some seronegative helper T-cell malignant lymphomas and monomorphic T-cell leukemia with round nuclei. These results suggest that those cases in the Nagasaki district, though clinically different from each other, might be the same T-lymphoproliferative disease of possible viral etiology associated with ATLV. On the other hand, persistent T-lymphocytosis seems to be an infectious condition caused by ATLV and partly a preclinical stage of ATLL in view of the clinicohematological features.
- Published
- 1983
49. [Morphological examination of lymphocytes from human T-cell leukemia virus (HTLV) carriers].
- Author
-
Amagasaki T, Momita S, Suzuyama J, Yamada Y, Ikeda S, Kinoshita K, and Ichimaru M
- Subjects
- Adult, Aged, Female, Humans, Leukemia, Lymphoid pathology, Lymphocytes immunology, Male, Middle Aged, Retroviridae Infections pathology, Antibodies, Viral analysis, Deltaretrovirus immunology, Leukemia, Lymphoid immunology, Lymphocytes pathology, Retroviridae Infections immunology
- Published
- 1985
50. Antibodies against p40tax gene product of human T-lymphotropic virus type-I (HTLV-I) under various conditions of HTLV-I infection.
- Author
-
Kamihira S, Toriya K, Amagasaki T, Momita S, Ikeda S, Yamada Y, Tomonaga M, Ichimaru M, Kinoshita K, and Sawada T
- Subjects
- Carrier State, Female, Follow-Up Studies, Humans, Infant, Newborn, Leukemia-Lymphoma, Adult T-Cell immunology, Pregnancy, Pregnancy Complications, Infectious immunology, Spinal Cord Diseases etiology, HTLV-I Antibodies analysis, HTLV-I Infections immunology, Human T-lymphotropic virus 1 immunology, Retroviridae Proteins immunology, Viral Proteins immunology
- Abstract
We investigated antibodies against pX gene product, p40tax, by ELISA using recombinant p40tax protein in HTLV-I seropositive carriers as well as patients with adult T cell leukemia (ATL) and HTLV-I-associated myelopathy (HAM). Seventy (49.0%) out of 143 HTLV-I healthy carriers were found to be positive for antibody against p40tax antigen and the follow-up samples at two-year intervals revealed constant reactivity by ELISA in each carrier. The onset of antibody production was delayed 4 to 12 weeks as compared with anti-HTLV-I in primary infection cases. The anti-p40tax-positive rate (90%) in HAM patients was significantly higher than that of healthy carriers, acute and chronic ATL patients and their family members. Furthermore, HAM patients and a few healthy carriers showed high reactivities by ELISA. Children from mothers with anti-p40tax showed a higher anti-HTLV-I-positive rate than that of children from mothers without anti-p40tax (54.5% versus 12.5%). Two men without anti-p40tax and one female with low anti-p40tax developed ATL during follow-up studies. These results suggest that HTLV-I carriers could be divided into 2 or 3 sub-populations according to antibody response to p40tax. A smaller population with anti-p40tax, especially a high antibody reactivity, could have a high risk of developing HAM and of transmission from mother to child. In addition, ATL may occur in a population with low or absent anti-p40tax.
- Published
- 1989
- Full Text
- View/download PDF
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