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1. optiPRM: A Targeted Immunopeptidomics LC-MS Workflow With Ultra-High Sensitivity for the Detection of Mutation-Derived Tumor Neoepitopes From Limited Input Material

Author

Salek, Mogjiborahman, Förster, Jonas D., Becker, Jonas P., Meyer, Marten, Charoentong, Pornpimol, Lyu, Yanhong, Lindner, Katharina, Lotsch, Catharina, Volkmar, Michael, Momburg, Frank, Poschke, Isabel, Fröhling, Stefan, Schmitz, Marc, Offringa, Rienk, Platten, Michael, Jäger, Dirk, Zörnig, Inka, and Riemer, Angelika B.

Published
2024
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4. Diverse cytomegalovirus US11 antagonism and MHC-A evasion strategies reveal a tit-for-tat coevolutionary arms race in hominids

Author

Zimmermann, Cosima, primary, Watson, Gabrielle M., additional, Bauersfeld, Liane, additional, Berry, Richard, additional, Ciblis, Barbara, additional, Lan, Huan, additional, Gerke, Carolin, additional, Oberhardt, Valerie, additional, Fuchs, Jonas, additional, Hofmann, Maike, additional, Freund, Christian, additional, Rossjohn, Jamie, additional, Momburg, Frank, additional, Hengel, Hartmut, additional, and Halenius, Anne, additional

Published
2024
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6. Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning.

Author

Gerke, Carolin, Bauersfeld, Liane, Schirmeister, Ivo, Mireisz, Chiara Noemi-Marie, Oberhardt, Valerie, Mery, Lea, Di Wu, Jürges, Christopher Sebastian, Spaapen, Robbert M., Mussolino, Claudio, Vu Thuy Khanh Le-Trilling, Trilling, Mirko, Dölken, Lars, Paster, Wolfgang, Erhard, Florian, Hofmann, Maike, Schlosser, Andreas, Hengel, Hartmut, Momburg, Frank, and Halenius, Anne

Published
2024
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7. MediMer: a versatile do-it-yourself peptide-receptive MHC class I multimer platform for tumor neoantigen-specific T cell detection

Author

Meyer, Marten, primary, Parpoulas, Christina, additional, Barthélémy, Titouan, additional, Becker, Jonas P., additional, Charoentong, Pornpimol, additional, Lyu, Yanhong, additional, Börsig, Selina, additional, Bulbuc, Nadja, additional, Tessmer, Claudia, additional, Weinacht, Lisa, additional, Ibberson, David, additional, Schmidt, Patrick, additional, Pipkorn, Rüdiger, additional, Eichmüller, Stefan B., additional, Steinberger, Peter, additional, Lindner, Katharina, additional, Poschke, Isabel, additional, Platten, Michael, additional, Fröhling, Stefan, additional, Riemer, Angelika B., additional, Hassel, Jessica C., additional, Roberti, Maria Paula, additional, Jäger, Dirk, additional, Zörnig, Inka, additional, and Momburg, Frank, additional

Published
2024
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9. Targeting colorectal cancer cells using AND-gated adaptor RevCAR T-cells

Author

Soto, Karla E. G., primary, Loureiro, Liliana R., additional, Bartsch, Tabea, additional, Arndt, Claudia, additional, Kegler, Alexandra, additional, Mitwasi, Nicola, additional, Drewitz, Laura, additional, Hoffmann, Lydia, additional, Saleh, Haidy A., additional, Crespo, Eugenia, additional, Mehnert, Maria, additional, Daglar, Cansu, additional, Abken, Hinrich, additional, Momburg, Frank, additional, Bachmann, Michael, additional, and Feldmann, Anja, additional

Published
2023
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10. optiPRM: A targeted immunopeptidomics LC-MS workflow with ultra-high sensitivity for the detection of mutation-derived tumor neoepitopes from limited input material

Author

Salek, Mogjiborahman, primary, Forster, Jonas D, additional, Becker, Jonas P, additional, Meyer, Marten, additional, Charoentong, Pornpimol, additional, Lyu, Yanhong, additional, Lindner, Katharina, additional, Lotsch, Catharina, additional, Volkmar, Michael, additional, Momburg, Frank, additional, Poschke, Isabel, additional, Frohling, Stefan, additional, Schmitz, Marc, additional, Offringa, Rienk, additional, Platten, Michael, additional, Jager, Dirk, additional, Zornig, Inka, additional, and Riemer, Angelika B, additional

Published
2023
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12. Supplementary Figure 3 from New Gene-Immunotherapy Combining TRAIL-Lymphocytes and EpCAMxCD3 Bispecific Antibody for Tumor Targeting

Author

Groth, Ariane, primary, Salnikov, Alexei V., primary, Ottinger, Sabine, primary, Gladkich, Jury, primary, Liu, Li, primary, Kallifatidis, Georgios, primary, Salnikova, Olga, primary, Ryschich, Eduard, primary, Giese, Nathalia, primary, Giese, Thomas, primary, Momburg, Frank, primary, Büchler, Markus W., primary, Moldenhauer, Gerhard, primary, and Herr, Ingrid, primary

Published
2023
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13. Supplementary Methods, Figure 1 from New Gene-Immunotherapy Combining TRAIL-Lymphocytes and EpCAMxCD3 Bispecific Antibody for Tumor Targeting

Author

Groth, Ariane, primary, Salnikov, Alexei V., primary, Ottinger, Sabine, primary, Gladkich, Jury, primary, Liu, Li, primary, Kallifatidis, Georgios, primary, Salnikova, Olga, primary, Ryschich, Eduard, primary, Giese, Nathalia, primary, Giese, Thomas, primary, Momburg, Frank, primary, Büchler, Markus W., primary, Moldenhauer, Gerhard, primary, and Herr, Ingrid, primary

Published
2023
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14. Supplementary Table 2 from New Gene-Immunotherapy Combining TRAIL-Lymphocytes and EpCAMxCD3 Bispecific Antibody for Tumor Targeting

Author

Groth, Ariane, primary, Salnikov, Alexei V., primary, Ottinger, Sabine, primary, Gladkich, Jury, primary, Liu, Li, primary, Kallifatidis, Georgios, primary, Salnikova, Olga, primary, Ryschich, Eduard, primary, Giese, Nathalia, primary, Giese, Thomas, primary, Momburg, Frank, primary, Büchler, Markus W., primary, Moldenhauer, Gerhard, primary, and Herr, Ingrid, primary

Published
2023
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15. Supplementary Methods, Figure 2 from New Gene-Immunotherapy Combining TRAIL-Lymphocytes and EpCAMxCD3 Bispecific Antibody for Tumor Targeting

Author

Groth, Ariane, primary, Salnikov, Alexei V., primary, Ottinger, Sabine, primary, Gladkich, Jury, primary, Liu, Li, primary, Kallifatidis, Georgios, primary, Salnikova, Olga, primary, Ryschich, Eduard, primary, Giese, Nathalia, primary, Giese, Thomas, primary, Momburg, Frank, primary, Büchler, Markus W., primary, Moldenhauer, Gerhard, primary, and Herr, Ingrid, primary

Published
2023
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16. Supplementary Table 1 from New Gene-Immunotherapy Combining TRAIL-Lymphocytes and EpCAMxCD3 Bispecific Antibody for Tumor Targeting

Author

Groth, Ariane, primary, Salnikov, Alexei V., primary, Ottinger, Sabine, primary, Gladkich, Jury, primary, Liu, Li, primary, Kallifatidis, Georgios, primary, Salnikova, Olga, primary, Ryschich, Eduard, primary, Giese, Nathalia, primary, Giese, Thomas, primary, Momburg, Frank, primary, Büchler, Markus W., primary, Moldenhauer, Gerhard, primary, and Herr, Ingrid, primary

Published
2023
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17. Supplementary Figure 1 from Intratumoral Cytokines and Tumor Cell Biology Determine Spontaneous Breast Cancer–Specific Immune Responses and Their Correlation to Prognosis

Author

Domschke, Christoph, primary, Schuetz, Florian, primary, Ge, Yingzi, primary, Seibel, Tobias, primary, Falk, Christine, primary, Brors, Benedikt, primary, Vlodavsky, Israel, primary, Sommerfeldt, Nora, primary, Sinn, Hans-Peter, primary, Kühnle, Marie-Christine, primary, Schneeweiss, Andreas, primary, Scharf, Alexander, primary, Sohn, Christof, primary, Schirrmacher, Volker, primary, Moldenhauer, Gerhard, primary, Momburg, Frank, primary, and Beckhove, Philipp, primary

Published
2023
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18. Supplementary Table 1 from Intratumoral Cytokines and Tumor Cell Biology Determine Spontaneous Breast Cancer–Specific Immune Responses and Their Correlation to Prognosis

Author

Domschke, Christoph, primary, Schuetz, Florian, primary, Ge, Yingzi, primary, Seibel, Tobias, primary, Falk, Christine, primary, Brors, Benedikt, primary, Vlodavsky, Israel, primary, Sommerfeldt, Nora, primary, Sinn, Hans-Peter, primary, Kühnle, Marie-Christine, primary, Schneeweiss, Andreas, primary, Scharf, Alexander, primary, Sohn, Christof, primary, Schirrmacher, Volker, primary, Moldenhauer, Gerhard, primary, Momburg, Frank, primary, and Beckhove, Philipp, primary

Published
2023
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19. Supplementary Figure 4 from Intratumoral Cytokines and Tumor Cell Biology Determine Spontaneous Breast Cancer–Specific Immune Responses and Their Correlation to Prognosis

Author

Domschke, Christoph, primary, Schuetz, Florian, primary, Ge, Yingzi, primary, Seibel, Tobias, primary, Falk, Christine, primary, Brors, Benedikt, primary, Vlodavsky, Israel, primary, Sommerfeldt, Nora, primary, Sinn, Hans-Peter, primary, Kühnle, Marie-Christine, primary, Schneeweiss, Andreas, primary, Scharf, Alexander, primary, Sohn, Christof, primary, Schirrmacher, Volker, primary, Moldenhauer, Gerhard, primary, Momburg, Frank, primary, and Beckhove, Philipp, primary

Published
2023
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20. Supplementary Figure 2 from Intratumoral Cytokines and Tumor Cell Biology Determine Spontaneous Breast Cancer–Specific Immune Responses and Their Correlation to Prognosis

Author

Domschke, Christoph, primary, Schuetz, Florian, primary, Ge, Yingzi, primary, Seibel, Tobias, primary, Falk, Christine, primary, Brors, Benedikt, primary, Vlodavsky, Israel, primary, Sommerfeldt, Nora, primary, Sinn, Hans-Peter, primary, Kühnle, Marie-Christine, primary, Schneeweiss, Andreas, primary, Scharf, Alexander, primary, Sohn, Christof, primary, Schirrmacher, Volker, primary, Moldenhauer, Gerhard, primary, Momburg, Frank, primary, and Beckhove, Philipp, primary

Published
2023
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21. Supplementary Table 2 from Intratumoral Cytokines and Tumor Cell Biology Determine Spontaneous Breast Cancer–Specific Immune Responses and Their Correlation to Prognosis

Author

Domschke, Christoph, primary, Schuetz, Florian, primary, Ge, Yingzi, primary, Seibel, Tobias, primary, Falk, Christine, primary, Brors, Benedikt, primary, Vlodavsky, Israel, primary, Sommerfeldt, Nora, primary, Sinn, Hans-Peter, primary, Kühnle, Marie-Christine, primary, Schneeweiss, Andreas, primary, Scharf, Alexander, primary, Sohn, Christof, primary, Schirrmacher, Volker, primary, Moldenhauer, Gerhard, primary, Momburg, Frank, primary, and Beckhove, Philipp, primary

Published
2023
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22. Supplementary Figure 3 from Intratumoral Cytokines and Tumor Cell Biology Determine Spontaneous Breast Cancer–Specific Immune Responses and Their Correlation to Prognosis

Author

Domschke, Christoph, primary, Schuetz, Florian, primary, Ge, Yingzi, primary, Seibel, Tobias, primary, Falk, Christine, primary, Brors, Benedikt, primary, Vlodavsky, Israel, primary, Sommerfeldt, Nora, primary, Sinn, Hans-Peter, primary, Kühnle, Marie-Christine, primary, Schneeweiss, Andreas, primary, Scharf, Alexander, primary, Sohn, Christof, primary, Schirrmacher, Volker, primary, Moldenhauer, Gerhard, primary, Momburg, Frank, primary, and Beckhove, Philipp, primary

Published
2023
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23. Data from Intratumoral Cytokines and Tumor Cell Biology Determine Spontaneous Breast Cancer–Specific Immune Responses and Their Correlation to Prognosis

Author

Domschke, Christoph, primary, Schuetz, Florian, primary, Ge, Yingzi, primary, Seibel, Tobias, primary, Falk, Christine, primary, Brors, Benedikt, primary, Vlodavsky, Israel, primary, Sommerfeldt, Nora, primary, Sinn, Hans-Peter, primary, Kühnle, Marie-Christine, primary, Schneeweiss, Andreas, primary, Scharf, Alexander, primary, Sohn, Christof, primary, Schirrmacher, Volker, primary, Moldenhauer, Gerhard, primary, Momburg, Frank, primary, and Beckhove, Philipp, primary

Published
2023
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24. Supplementary Figure 5 from Intratumoral Cytokines and Tumor Cell Biology Determine Spontaneous Breast Cancer–Specific Immune Responses and Their Correlation to Prognosis

Author

Domschke, Christoph, primary, Schuetz, Florian, primary, Ge, Yingzi, primary, Seibel, Tobias, primary, Falk, Christine, primary, Brors, Benedikt, primary, Vlodavsky, Israel, primary, Sommerfeldt, Nora, primary, Sinn, Hans-Peter, primary, Kühnle, Marie-Christine, primary, Schneeweiss, Andreas, primary, Scharf, Alexander, primary, Sohn, Christof, primary, Schirrmacher, Volker, primary, Moldenhauer, Gerhard, primary, Momburg, Frank, primary, and Beckhove, Philipp, primary

Published
2023
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25. Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning

Author

Gerke, Carolin, primary, Bauersfeld, Liane, additional, Oberhardt, Valerie, additional, Jürges, Christopher Sebastian, additional, Spaapen, Robbert M., additional, Mussolino, Claudio, additional, Le-Trilling, Vu Thuy Khanh, additional, Trilling, Mirko, additional, Dölken, Lars, additional, Erhard, Florian, additional, Hofmann, Maike, additional, Hengel, Hartmut, additional, Momburg, Frank, additional, and Halenius, Anne, additional

Published
2023
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32. Hepatitis B virus envelope proteins can serve as therapeutic targets embedded in the host cell plasma membrane

Author

Zhao, Lili, primary, Chen, Fuwang, additional, Quitt, Oliver, additional, Festag, Marvin, additional, Ringelhan, Marc, additional, Wisskirchen, Karin, additional, Festag, Julia, additional, Yakovleva, Luidmila, additional, Sureau, Camille, additional, Bohne, Felix, additional, Aichler, Michaela, additional, Bruss, Volker, additional, Shevtsov, Maxim, additional, Klundert, Maarten, additional, Momburg, Frank, additional, Möhl, Britta S., additional, and Protzer, Ulrike, additional

Published
2021
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33. T-cell engager antibodies enable T cells to control HBV infection and to target HBsAg-positive hepatoma in mice

Author

Quitt, Oliver, primary, Luo, Shanshan, additional, Meyer, Marten, additional, Xie, Zhe, additional, Golsaz-Shirazi, Forough, additional, Loffredo-Verde, Eva, additional, Festag, Julia, additional, Bockmann, Jan Hendrik, additional, Zhao, Lili, additional, Stadler, Daniela, additional, Chou, Wen-Min, additional, Tedjokusumo, Raindy, additional, Wettengel, Jochen Martin, additional, Ko, Chunkyu, additional, Noeßner, Elfriede, additional, Bulbuc, Nadja, additional, Shokri, Fazel, additional, Lüttgau, Sandra, additional, Heikenwälder, Mathias, additional, Bohne, Felix, additional, Moldenhauer, Gerhard, additional, Momburg, Frank, additional, and Protzer, Ulrike, additional

Published
2021
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34. Activating Natural Killer Cell Receptors, Selectins, and Inhibitory Siglecs Recognize Ebolavirus Glycoprotein

Author

Jarahian, Mostafa, primary, Marstaller, Katharina, additional, Banna, Nadine, additional, Ahani, Roshanak, additional, Etemadzadeh, Mohammad Hossein, additional, Boller, Lea K., additional, Azadmanesh, Kayhan, additional, Cid-Arregui, Angel, additional, Khezri, Abdolrahman, additional, Berger, Martin R., additional, Momburg, Frank, additional, and Watzl, Carsten, additional

Published
2021
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35. Co-Stimulatory Bispecific Antibodies Induce Enhanced T Cell Activation and Tumor Cell Killing in Breast Cancer Models

Author

Warwas, Karsten M., primary, Meyer, Marten, additional, Gonçalves, Márcia, additional, Moldenhauer, Gerhard, additional, Bulbuc, Nadja, additional, Knabe, Susanne, additional, Luckner-Minden, Claudia, additional, Ziegelmeier, Claudia, additional, Heussel, Claus Peter, additional, Zörnig, Inka, additional, Jäger, Dirk, additional, and Momburg, Frank, additional

Published
2021
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37. NKG2A‐checkpoint inhibition and its blockade critically depends on peptides presented by its ligand HLA‐E.

Author

Battin, Claire, Kaufmann, Gabriel, Leitner, Judith, Tobias, Joshua, Wiedermann, Ursula, Rölle, Alexander, Meyer, Marten, Momburg, Frank, and Steinberger, Peter

Subjects
SIGNAL peptides, HISTOCOMPATIBILITY antigens, T cell receptors, PEPTIDES, KILLER cells, IMMUNE checkpoint inhibitors, T cells
Abstract

NKG2A has emerged as a new immunotherapy target and its blockade with the novel immune checkpoint inhibitor (ICI) monalizumab can boost both NK cell and CD8+ T cell responses. NKG2A forms heterodimers with CD94 and binds to the human non‐classical MHC class I molecule HLA‐E. HLA‐E forms complexes with a limited set of peptides mainly derived from the leader sequences of the classical MHC class I molecules (HLA‐A, HLA‐B and HLA‐C) and the non‐classical class I paralogue HLA‐G, and it is well established that the interaction between CD94/NKG2x receptors and its ligand HLA‐E is peptide‐sensitive. Here, we have evaluated peptide dependence of NKG2A‐mediated inhibition and the efficiency of interference by monalizumab in a transcriptional T cell reporter system. NKG2A inhibition was mediated by cell‐expressed HLA‐E molecules stably presenting disulfate‐trapped peptide ligands. We show that different HLA‐class I leader peptides mediate varying levels of inhibition. We have used NKG2A/NKG2C chimeric receptors to map the binding site of NKG2A and NKG2C blocking antibodies. Furthermore, we determined the functional EC50 values of blocking NKG2A antibodies and show that they greatly depend on the HLA‐leader peptide presented by HLA‐E. Monalizumab was less effective in augmenting NK cell‐mediated killing of target cells displaying HLA‐G peptide on HLA‐E, than cells expressing HLA‐E complexed with HLA‐A, HLA‐B and HLA‐C peptides. Our results indicate that peptides displayed by HLA‐E molecules on tumour cells might influence the effectivity of NKG2A‐ICI therapy and potentially suggest novel approaches for patient stratification, for example, based on tumoral HLA‐G levels. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Rapid T cell--based identification of human tumor tissue antigens by automated two-dimensional protein fractionation

Author

Beckhove, Philipp, Warta, Rolf, Lemke, Britt, Stoycheva, Diana, Momburg, Frank, Schnolzer, Martina, Warnken, Uwe, Schmitz-Winnenthal, Hubertus, Ahmadi, Rezvan, Dyckhoff, Gerhard, Bucur, Mariana, Junger, Simone, Schueler, Thomas, Lennerz, Volker, Woelfel, Thomas, Unterberg, Andreas, and Herold-Mende, Christel

Subjects
T cells -- Properties -- Research, Cancer -- Care and treatment, Cellular proteins -- Properties -- Research, Tumor antigens -- Identification and classification -- Research, Health care industry
Abstract

Identifying the antigens that have the potential to trigger endogenous antitumor responses in an individual cancer patient is likely to enhance the efficacy of cancer immunotherapy, but current methodologies do not efficiently identify such antigens. This study describes what we believe to be a new method of comprehensively identifying candidate tissue antigens that spontaneously cause T cell responses in disease situations. We used the newly developed automated, two-dimensional chromatography system PF2D to fractionate the proteome of human tumor tissues and tested protein fractions for recognition by preexisting tumor-specific [CD4.sup.+] Th cells and CTLs. Applying this method using mice transgenic for a TCR that recognizes an OVA peptide presented by MHC class I, we demonstrated efficient separation, processing, and cross-presentation to [CD8.sup.+] T cells by DCs of OVA expressed by the OVA-transfected mouse lymphoma RMA-OVA. Applying this method to human tumor tissues, we identified MUC1 and EGFR as tumor-associated antigens selectively recognized by T cells in patients with head and neck cancer. Finally, in an exemplary patient with a malignant brain tumor, we detected [CD4.sup.+] and [CD8.sup.+] T cell responses against two novel antigens, transthyretin and calgranulin B/S100A9, which were expressed in tumor and endothelial cells. The immunogenicity of these antigens was confirmed in 4 of 10 other brain tumor patients. This fast and inexpensive method therefore appears suitable for identifying candidate T cell antigens in various disease situations, such as autoimmune and malignant diseases, without being restricted to expression by a certain cell type or HLA allele., Introduction In basic and translational immunology, identifying antigens that trigger pathogenic T cell responses in autoimmune disease or potential target antigens for immunotherapy of tumors still poses a major challenge. [...]

Published
2010
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40. The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a 'molecular ruler' mechanism

Author

Chang, Shih-Chung, Momburg, Frank, Bhutani, Nidhi, and Goldberg, Alfred L.

Subjects
Antigen presenting cells -- Research, Aminopeptidases -- Research, Aminopeptidases -- Properties, Major histocompatibility complex -- Research, Science and technology
Abstract

Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an IFN-[gamma]induced aminopeptidase in the endoplasmic reticulum that trims longer precursors to the antigenic peptides presented on MHC class I molecules. We recently reported that purified ERAP1 trimmed N-extended precursors but spared peptides of 8-9 residues, the length required for binding to MHC class I molecules. Here, we show another remarkable property of ERAP1: that it strongly prefers substrates 9-16 residues long, the lengths of peptides transported efficiently into the ER by the transporter associated with antigen processing (TAP) transporter. This aminopeptidase rapidly degraded a model 13-mer to a 9-mer and then stopped, even though the substrate and the product had identical N- and C-terminal sequences. No other aminopeptidase, including the closely related ER-aminopeptidase ERAP2, showed a similar length preference. Unlike other aminopeptidases, the activity of ERAP1 depended on the C-terminal residue of the substrate. ERAP1, like most MHC class I molecules, prefers peptides with hydrophobic C termini and shows low affinity for peptides with charged C termini. Thus, ERAP1 is specialized to process precursors transported by TAP to peptides that can serve as MHC class I epitopes. Its 'molecular ruler' mechanism involves binding the hydrophobic C terminus of the substrate 9-16 residues away from the active site. antigen presentation | antigen processing | proteases

Published
2005

41. Hepatitis B virus envelope proteins can serve as therapeutic targets embedded in the host cell plasma membrane

Author

Zhao, Lili, primary, Chen, Fuwang, additional, Quitt, Oliver, additional, Festag, Marvin, additional, Ringelhan, Marc, additional, Wisskirchen, Karin, additional, Hasreiter, Julia, additional, Yakovleva, Luidmila, additional, Sureau, Camille, additional, Bohne, Felix, additional, Aichler, Michaela, additional, Bruss, Volker, additional, Shevtsov, Maxim, additional, van de Klundert, Maarten, additional, Momburg, Frank, additional, Möhl, Britta S., additional, and Protzer, Ulrike, additional

Published
2020
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47. Activating NK- receptors, homing selectins and inhibitory Siglecs recognize EBOLA-GP and HPV-L1NK

Author

Jarahian, Mostafa, primary, Marstaller, Katharina, additional, Wurmbäck, Heribert, additional, Banna, Nadine, additional, Ahani, Roshanak, additional, Etemadzadeh, Hossein, additional, Boller, Lea Katharina, additional, Azadmanesh, Kayhan, additional, Cid-Arregui, Angel, additional, Berger, Martin R, additional, Momburg, Frank, additional, and Watzl, Carsten, additional

Published
2020
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49. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance

Author

Limmer, Andreas, Ohl, Jutta, Kurts, Christian, Ljunggren, Hans-Gustaf, Reiss, Yuval, Groettrup, Marcus, Momburg, Frank, Arnold, Bernd, and Knolle, Percy A.

Subjects
Antigen presenting cells -- Health aspects, Antigen presenting cells -- Research, CD8 lymphocytes -- Health aspects, CD8 lymphocytes -- Research, Cellular immunity -- Research
Abstract

Myeloid antigen-presenting cells (APC) are known to cross-present exogenous antigen on major histocompatibility class I molecules to CD8[sup.+] T cells and thereby induce protective immunity against infecting microorganisms. Here we report that liver sinusoidal endothelial cells (LSEC) are organ-resident, non-myeloid APC capable of cross-presenting soluble exogenous antigen to CD8[sup.+] T cells. Though LSEC employ similar molecular mechanisms for cross-presentation as dendritic cells, the outcome of cross-presentation by LSEC is CD8[sup.+] T cell tolerance rather than immunity. As uptake of circulating antigens into LSEC occurs efficiently in vivo, it is likely that cross-presentation by LSEC contributes to CD8[sup.+] T cell tolerance observed in situations where soluble antigen is present in the circulation., Author(s): Andreas Limmer [1, 7]; Jutta Ohl [1, 7]; Christian Kurts [2]; Hans-Gustaf Ljunggren [3]; Yuval Reiss [4]; Marcus Groettrup [5]; Frank Momburg [6]; Bernd Arnold [6]; Percy A. Knolle [...]

Published
2000
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