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1. Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial

Author

Estcourt, Lise J, McQuilten, Zoe K, Bardy, Peter, Cole-Sinclair, Merrole, Collins, Graham P., Crispin, Philip J., Curnow, Elinor, Curnow, Jennifer, Degelia, Amber, Dyer, Claire, Friebe, Adam, Floro, Lajos, Grand, Effie, Hudson, Cara, Jones, Gail, Joseph, Joanne, Kallmeyer, Charlotte, Karakantza, Marina, Kerr, Paul, Last, Sara, Lobo-Clarke, Maria, Lumley, Matthew, McMullin, Mary F, Medd, Patrick G., Morton, Suzy M., Mumford, Andrew D., Mushkbar, Maria, Parsons, Joseph, Powter, Gillian, Sekhar, Mallika, Smith, Laura, Soutar, Richard, Stevenson, William S., Subramoniapillai, Elango, Szer, Jeff, Thomas, Helen, Waters, Neil A., Wei, Andrew H., Westerman, David A., Wexler, Sarah A., Wood, Erica M., Stanworth, Simon J., Abioye, Adrienne, Afghan, Rabia, Ai, Sylvia Ai, Akanni, Magbor, Alajangi, Rajesh, Alam, Usmaan, Al-Bubseeree, Bahaa, Alderson, Sophie, Alderson, Craig, Ali, Sayed, Ali, Kabir, Alighan, Rookmeen, Allam, Rebecca Allam, Allen, Tania, Al-Sakkaf, Wesam, Ames, Kate, Anderson, Jacqueline, Andrews, Colin, Angel, Ann-Marie, Anlya, Manuela Anlya, Ansari, Farah, Appleby, Rowan, Arnold, Claire, Asbjornsdottir, Hulda, Asfaw, Biruk, Atkins, Elissa, Atkinson, Leela, Aubrey, Clare, Ayesha, Noor, Babbola, Lola, Badcock, David, Badcock, Samuel, Baggio, Diva, Bailiff, Ben, Baines, Kizzy, Baker, Holly, Baker, Victoria, Ball, Lindsay, Ball, Martin, Balquin, Irwin, Banks, Emma, Banos, George, Barnett, Jaytee, Barrie, Claire, Barron, Claire, Barton, Rebecca, Bason, Nina, Batta, Bindu, Bautista, Dianne, Bayley, Angela, Bayly, Emma, Baynes, Fionnuala, Bazargan, Ali, Bazeley, Rachel, Beadle, Yvonne, Beardsmore, Claire, Beattie, Kate, Bedford, Caroline, Behal, Rachna, Behan, Daniel, Bejan, Lilihna, Bell, Sarah, Bell, Karen, Bell, Louise, Bell, Kaitlyn, Benjamin, Reuben, Bennett, Sam, Benson, Gary, Benson, Warwick, Bent, Cameron, Bergin, Krystal, Berry, Alex, Besenyei, Stephanie, Besley, Caroline, Betteridge, Scott, Beveridge, Leigh, Bhattacharyya, Abir, Billen, Annelies, Bilmon, Ian, Binns, Emma, Birt, Mark, Bishop, David, Blanco, Andrea, Bleby, Lisa, Blemnerhet, Richard, Blombery, Piers, Blyth, Emily, Blythe, Nicola, Boal, Lauren, Boden, Ali, Bokhari, Syed W.I., Bongetti, Elisa, Booth, Stephen, Borley, Jayne, Bowen, David, Bowers, Dawn, Boyd, Stephen, Bradley, Sarah, Bradman, Helen, Bretag, Peta, Brillante, Maria, Brockbank, Rachel, Brough, Yasmin, Brown, Ellen, Brown, Jo, Brown, Eleanor, Brown, Claire, Brown, Jenny, Brown, Susan, Browning, Joe, Brownsdon, Alex, Bruce, David, Brydon-Hill, Ruth, Buckwell, Andrea, Burgess, Dannielle, Burke, Glenda, Burley, Kate, Burney, Claire, Burns, David, Burrows, Samuel, burton, Kieran, Butler, Jason, Cambalova, Lenka, Camozzi, Maria C., Campbell, Philip, Campfield, Karen, Campion, Victoria, Cargo, Catherine, Carmona, Julia, Carney, Dennis, Casan, Joshua, Cashman, Helen, Catt, Lorraine, Cattell, Michael, Cavill, Megan, Chadbone, Rachel, Chaganti, Sridhar, Chai, Yee, Chai, Khai Li, Chang, Joshua, Chapman, Judith, Chapman, Oliver G., Chapter, Tamika, Charlton, Andrew, Chau, Celina, Chauhan, Saleena, Chavda, Nikesh, Chen, Frederick, Chen, Melody, Chen, Meng Xi, Chen, Melanie, Chen, Melissa, Cheok, Kathleen, Cheung, Mai, Chidgey, Luke, Chmielokliec, Karolina, Choi, Philip, Choi, Jae, Chok, Anne, Chopra, Ruchika, Christopherson, Louise, Chu, Vicky, Chua, Chong Chyn, Chudakou, Pavel, Chugh, Vidushi, Chung, Chi, Clark, Erin, Clarke, Peter, Clarke, Kathleen, Clay, Jennifer, Clayton, Laura, Clements, Mitch, Clemmens, Jonathan, Clifford, Ruth, Collett, Dave, Collins, Maia, Collyer, Emily, Connolly, Maureen, Cook, Mark, Coombs, Sarah, Coppell, Jason, Cornwell, Sophie, Corrigan, Claire, Coughlin, Elizabeth, Couling, Jennifer, Cousins, Tony, Cowan, Catriona, Cox, Christine, Cox, Catherine, Coyle, Luke, Craig, Emily, Creasey, Thomas, Croan, Laura, Croft, Jane, Crosbie, Nicola, Crowe, Josephine, Crowther, Helen, Crozier, Jane, Culleton, Naomi, Cullis, Jonathan, Cumming, Anita, Cummins, Michelle, Cunningham, Adam, Curley, Cameron, Curtis, Samantha, Cuthbert, Robert, Cuthill, Kirsty, Dahahayake, Dinusha A, Dang, Amy, Davies, Marc, Davies, Ceri, Dawson, Emily, Day, Tom, De Abrew, Kanchana, De Lavallade, Hugues, De Silva, Neelaskshi, Dean, Georgina, Deane, Christopher, Demosthenous, Lisa, Desai, Amisha, Desborough, Michael, Devanny, Ian, Dhanapal, Jay, Dhani, Sundip, Di Martino, Vicky, Dickens, Emmy, DiCorleto, Carmen, Dinnett, Louise, Dirisan, Divya, Dixon, Karen, Dixon, Kiri, Doal, Inderjit, Dobivh, J, Docanto, Maria, Doecke, Helve, Donaldson, David, Donaldson, Kylee, Donohoe, Carrie, Douglas, Ashley, Doung, Stephen, Downer, Susan, D'Rozario, James, Drummond, Malcolm, Drummond, Mark, Drummond, Samantha, Drysdale, Elizabeth, D'Souza, Ross, D'Souza, Eugene, Dunn, Alex, Dutton, David, Dyson, Martin, Ediriwicurena, Kushani, Edleston, Sharon, Edwards, Dawn, Edwards, Morgan, Edwards, Anita, Eise, Nicole, Ellis, Steven, Ellis, Hayley, Elmonley, Shareef, Enstone, Rosemarie, Eordogh, Agnes, Erb, Sharon, Evans, Shannon, Evans, Megan, Ewing, Joanne, Eyre, Toby, Facey, Adam, Fammy, Mina, Farman, Jon, Farnell, Rachel, Favero, Laura, Fay, Keith, Ferguson, Karen, Fernon, Laura, Filshie, Robin, Finnegan, Damian, Fisher, Lisa, Flanagan, Asia, Fleck, Emma, Fletcher, Simon, Flora, Harpreet, Flower, Catherine, Fodor, Ioana, Foley, Heather, Folland, Emma, Folorunso, Comfort, Forbes, Molly, Fordwor, Katrina, Foster, Polly, Fox, Vanessa, Fox, Thomas, Francis, Olesya, Fryearson, Louise, Fuery, Madonna, Fung, Jiin, Furtado, Michelle, Galloway-Browne, Leanne, Gamble, Louise, Gamgee, Jeanette, Ganapathy, Arundathi, Gardner, Hayley, Gardner, Clare, Gasmelsheed, Noha, Gately, Amy, Gaynor, Lynda, Gebreid, Alex, Geffens, Ruth, George, Rachel, Gertner, Aniko, Ghebeh, Manar, Ghirardini, Emanuela, Giddings, Melainie, Gillett, Sandra, Gillett, Karen, Giri, Pratyush, Glass, Chris, Glewis, Sarah, Gooding, Sarah, Gordon, Olivia, Gordon, Joanne, Gottlieb, David, Gowda, Koushik, Gower, Elysie, Gray, Nicola, Grayer, Jo, Greaves, Elaine, Greenaway, Sally Anne, Greenfield, Graeme, Greenwood, Matthew, Gregory, Gareth, Griffin, James, Griffith, Julia, Griffith, James, Griffiths, Lindsey, Grzegrzolka, Paulina, Gu, Yisu, Guest, Jo, Guinai, Rosanna, Gullapalli, Veena, Gunolr, A., Guo, Lina, H, Wayne, Hagua, Sophia, Haile, Senait, Hall, Richard, Hamdollah-Zadeh, Maryam, Hanif, Zahra, Hanlon, Kathleen, Hann, Nicholas, Hanna, Ramez, Hannah, Guy, Hapuarachchi, Sameera, Hardman, Jacinta, Hardy, Alison, Harris, Anthony, Harris, Kylie, Harrison, Beth, Harrison, Simon, Harrison, Lea-Anne, Harrop, Sean, Harvey, Caroline, Hatcliffe, Faye, Hawking, Jo, Hawkins, Matthew, Hayden, Janet, Hayman, Michelle, Haynes, Elizabeth, Heaney, Nicholas, Hebbard, Andrew, Hempton, Jenny, Hendunneti, Sasanka, Henry, Maeve, Heywood, Jonathan, Hildyard, Catherine, Hill, Lydia, Hilldrith, Annette, Hitev, Petar, Hiwase, Smita, Hiwase, Devendra, Hoare, Chris, Hodge, Renate, Holloway, Amy, Holt, Chloe, Holton, Kelly, Homer, Lauren, Horne, Gillian, Horvath, Noemi, Hotong, Linda, Houdyk, Kristen, Houseman, Katy, Hoxhallari, Ilda, Hsu, Hannah, Hsu, Nina, Huang, Gillian, Hudson, Kerryn, Hufton, Melanie, Hughes, Timothy, Hughes, Siobhan, Hurley, Kate, Huxley, Rosie, Ibitoye, Temitope, Ibrouf, Abubaken, Inam, Farha, Indran, Tishya, Ingham, Karen, Innes, Calum, Irvine, David, Jaafar, Sarah, Jain, Manish, Jameson, Laura, Janjua, Pardeep, Jarvis, Rebecca, Jatheendran, Abirami, Javed, Abbie, Jen, Sheila, Jobanpura, Shailesh, Jobson, Irene, John, Deborah, Johns, Sophie, Johnston, Amanda, Jones, Hollie, Jones, Francesca, Joniak, Karolina, Jovanovic, Michael, Jovic, Anita, Joyce, Lauren, Judd, Andrew, Kakarlamudi, Sudhakar, Kakaroubas, Nick, Kalita, Maggie, Kam, Shirly, Kan, Julie, Kandle, P, Kanellopoulos, Alex, Kao, Chien, Kaparou, Maria, Kartsios, Charamlampos, Katsioulas, Vicki, Kaye, Russell, Keen, Katie, Kelly, Richard, Kelly, Pauline, Kelly, Donna, Kelly, Melanie, Kennedy, Glen, Kennedy, Nola, Kenny, Angela, Kenworthy, Zoe, Kerridge, Ian, Kesavan, Murali, Khafizi, Angelika, Khakwani, Muhammad, Khalid, Amna, Khamly, Kate, Khan, Anjum, Khan, Dalia, Khan, Mojid, Khan, Lubna, Khoo, Mona, Khwaja, Asim, Kim, Grace, King, Andrew, King, Vicky, King, Donna, Kinsella, Francesca, Kipp, David, Kirandeep, Pachoo, Kirui, Laura C., Kishore, Bhuvan, Knectlhi, Christopher, Knot, Amy, Knot, Armit, Ko, Cathy, Kolaric, Caitlin, Koo, Ray, Kotadia, Mary, Kothari, Jaimal, Kottaridis, Panagiotis D., Kuiluinathan, Gajan, Kulasekararaj, Austin, Kwan, John, Kwok, Marwan, Kwok, Phillip, Kwok, Fiona, Laane, Kristiina, Lad, Deena, Laird, Jennifer, Lam, Ada, Lane, Mary, Lanenco, Monica, Lang, Susan, Langridge, Alex, Langton, Catherine, Lannon, Michelle, Latif, Annie, Latimer, Maya, Latter, Ruth, Lau, I-Jun, Lawless, Sarah, Lawless, Theresa, Leach, Mike, Leaney, Sarah, Leary, Heather, Leavy, James, LeBlanc, Abbey, Lee, Vivienne, Lee, Edwin, Lee, Jenny, Lee, Tamara, Leischkie, Marian, Leitinger, Emma, Leon, Christopher, Leonard, Jayne, Lewis, David, Lewis, Ian, Lewis, Tania, Lim, Daniel, Littlewood, Kelly, Liu, Dara, Loh, Joanna, Lokare, Anand, Lomas, Oliver, Lovell, Richard, Lowe, Theresa, Lowry, Lisa, Lubowiecki, Marcin, Lumb, Rebecca, Lynch, Gail, Macaulay, Amanda, MacDonald, Lyndsey, MacDonald-Burn, Jill, Macmillan, Margaret, Maddock, Karen, Mahaliyana, Tomas, Mahon, Cassandra, Maidment, Alison, Maier, Susie, Mairos, Michelle, Majid, Mahseeman, Mak, Ka L, Mak, Anne, Malendrayogau, Arunthrthy, Malham, Hana, Malyon, Felicity, Mandadapu, Vineela, Mandel, Laura, Mant, Sarah, Manton, Ruth, Maouche, Nadjoua, Maqbool, Muhammad G., Marchant, Gregory, Marinho, Mariana, Marks, David, Marner, Mike, Marr, Helen, Marshall, Gillian, Martin, Siobhan, Martin, Abigail, Marzolini, Maria, Mason, Kiara, Massie, Jonathan, Masson, Rebecca, Mathavan, Vidya, Mathew, Siju, Mathie, Judith, Mattocks, Lehenta, Maybury, Bernard, Mayer, Georgina, McAlister, Chyrelle, McAllister, Jo, McConnell, Stewart, McCracken, James, McCullagh, Liz, McCulloch, Rory, Mcdermott, Christopher, Mcdonald, Kerian, McGinniss, Laura, McGurk, Fiona, McIlwain, Jessica, McIver, Kirsten, Mckay, Pam, McKenna, Lorraine, Mclornan, Donal, McMahon, Coalon, McNeice, Linda, McNeill, Susan, McNickle, Molly, McQueen, Fiona, McRae, Simon, McTaggart, Bobby, Mehew, Jenny, Mehra, Varnn, Melly, Michelle, Menichelli, Tara, Micklethwatte, Ken, Mihailescue, Loredana, Mijovic, Aleksander, Millband, Hannah, Miller, Lucy, Millien, Samuel T., Milnthorpe, James, Minson, Adrian, Molnar, Eva, Monsour, Marc, Moody, Mary, Moon, Rebecca, Moore, Sally, Moore, Katy, Morgan, Kelly, Morralley, Rebecca, Morris, Denise, Morris, Kirk, Morrison, Nicole, Moss, Merinda, Mughal, Muhammad, Muir, Paul, Mukkath, David, Mulla, Aasiyu, Mulligan, Stephen, Mullings, Joanne, Mulqueen, Angela, Muluey, Caitlin, Murdoch, Sarah, Murrani, Sura, Murthy, Vidhya, Musngi, Jimmy, Mustafa, Nadreen, Mynes, Tracey, Nalpantidis, Anastasios, Nandurkar, Harshal, Nardone, Linda, Nasari, Latifa, Nash, Monica, Naylor, Georgina, Ngu, Loretta, Nguethina, Melissa, Nguyen, John, Nguyen, Joseph, Nichol, Wendy, Nicholls, Emma, Nicole, Catherine S., Nicolson, Phillip, Nielson, David, Nikolousis, Emmanouil, Nix, Georgina, Njoku, Rita, Norman, Jane, Norman, Amy, Norris, Phoebe, North, Daniel, Norwood, Megan, Notcheva, Gaynor, Novitzky-Basso, Igor, Nyaboko, Joseph, Nygren, Maria, Obu, Ingrid, O'Connell, Siobhan, O'Connor, Jody, O'Kelly, Deanna, O'Niell, Aideen, Ony, Jeremy, Oo, Kathy, Oo, April, Oppermann, Anne, Orr, Ruth, O'Sullivan, Mary, Page, Jennifer, Palfreyman, Emma, Paneesha, Shankaranarayana, Panicker, Shyam, Parbutt, Catherine, Parigi, Elesha, Paris, Gemma, Parker, Tracey, Parnell, Caroline, Parrish, Christopher, Parsons, Alex, Pasat, Mioara, Patel, Natasha, Patel, Vijay, Patel, Pooja, Patel, Chaya, Pati, Nalini, Patterson, Andrea, Paul, Lauren, Payet, Danielle, Payne, Elspeth, Peachey, Victoria, Pearson, Amanda, Peniket, Andy, Percy, Laura, Pereyra, Millicent, Pervaiz, Omer, Phalod, Gunjan D, Pham, Anh, Pho, Jason, Pickard, Keir, Pidcock, Michael, Piggin, Anna, Pishyar, Yalda, Pocock, Abigail, Pol, Ranjendres, Polzella, Paolo, Poolan, Sonia, Portingale, Vicki, Posnett, Claire, Potluri, Sandeep, Potter, Victoria, Pratt, Guy, Prodger, Catherine, Pueblo, Andres, Puliyayil, Anish, Puvanakumar, Pratheepan, Qadri, Abdul, Quach, Hang, Quinn, Michael, Rafferty, Mark, Rahman, Marzia, Raj, Kavita, Raj, Sonia, Rajendran, Ramina, Ramanan, Radha, Ramasamy, Karthik, Rampotas, Alexandros, Ranchhod, Natasha, Rashid, Sabia, Ratanjee, Sunita, Rathore, Gurpreet, Ratnasingam, Sumita, Rayat, Manjit, Rayner, Michael, Reddell-Denton, Rebecca, Redding, Nicola, Reddy, Udaya, Rehman, Atique, Rice, Carol, Riches, Iwona, Rider, Thomas, Riley, John, Rinaldi, Ciro, Roberts, Kayleigh, Roberts, Andrew, Robertson, Bryony, Robertson, Peter, Robinson, Dan, Robinson, Rebecca, Robjohns, Emma, Robledo, Laura, Rodrigues, Ana, Rofe, Chris, Roff, Bridie, Rogers, Rachel, Rolt, Jill, Rooney, Carmela, Rose, Kathy, Rose, Hannah, Ross, David, Rouf, Shahara, Rourke, Claire, Routledge, David, Ruggiero, Janet, Rule, Simon, Rumsey, Richard, Sagge, Cherry, Saldhana, Helen, Salisbury, Richard, Salisbury, Sarah, Salvaris, Ross, Sanders, Kay, Sangombe, Mirriam, Sanigorska, Anna, Santos, Kristine, Sarkis, Taylah, Sarma, Anita, Saunders, Natalie, Schmidt, Kara, Schmidtmann, Anja, Schumacher, Ann, Scorer, Tom Scorer, Scott, Asleigh, Seath, Ingrid, Sejman, Frances, Selim, Adrian, Shamim, Nadia, Shan, Jocelyn, Shanmuganathan, Naranie, Shanmugaranjan, Shaminie, Sharpe, Michelle, Sharpley, Faye, Shaw, Emma, Sheath, Cara, Sheehy, Oonagh, Shen, Vivian, Sherbide, Solomon, Sheridan, Mathew, Sheridan, Jane, Sheridon, Matthew, Shields, Tracy, Sim, Hau V, Sim, Shirlene, Sims, Matt, Singaraveloo, Lydia, Singh, Gurcharan, Singh, Jasmine, Sladesal, Shree, Sloan, Andrew, Slobodian, Peter, Smith, Sophie, Smith, Sarit, Smith, Claire, Smith, Alastair, Smith, Neil, Snowden, Katherine, Solis, Joel, Somios, Denise, Soo, Jade, Spanevello, Michelle, Spaulding, Madeleie, Spence, Laura, Spillane, Liz, Spiteri, Alisha, Sprigg, Naomi, Springett, Sally, Stafford, Lynn, Stainthorp, Katherine, Stark, Kate, Steeden, Louise, Stephen, Ella, Stephenson, Aisling, Stewart, Andrew, Stewart, Orla, Stobie, Emma, Stokes, Chelsea, Streater, Jacqui, Suddens, Charlie-Marie, Suntharalingam, Surenthini, Surana, Narinder, Sutherland, Robyn, Sutherland, Antony, Sutton, David, Sweeney, Connor, Sweet, Reilly, Szucs, Aniko P, Taheri, Leila E., Tailor, Hinesh, Tam, Constantine, Tambakis, George, Tamplin, Mary, Tan, Chee, Tan, Sui, Tan, Joanne, Tan, Zhi, Taran, Tatiana, Tarpey, Fiona, Taseka, Angela, Tasker, Suzy, Tatarczuch, Maciej, Tayabali, Sarrah, Taylor, Hannah, Taylor, Robert, Taylor, Melaine, Taylor-Moore, Ella, Teasdale, Lesley, Tebbet, Elizabeth, Tedjasepstra, Aditya, Tedjaseputra, Aditya, Tepkumkun, Oummy, Terpstra, Andrew, Thomas, Wayne, Thomas, Shanice, Thompson, Rachel, Thornton, Thomas, Thorp, Bronwyn, Thrift, Moi Yap, Thwaites, Phillipa, Timbres, Jasmine, Tindall, Lauren, Tiong, Ing Soo, Tippler, Nicole, Todd, Tony, Todd, Shirley, Toghill, Neil, Tomlinson, Eve, Tooth, Jacinta, Topp, M., Trail, Nicola, Tran, Nguyen, Tran, Elizabeth, Tran, Vi, Treder, Bona, Tribbeck, Michelle, Trochowski, Siobhan, Truslove, Maria, Tse, Tsun, Tseu, Bing, Tucker, David, Turner, Kelly, Turner, Dianne, Turner, Herleen, Turner, Gillian, Twohig, Julie, Tylee, Thomas, Uhe, Micheleine, Underhill, Lauren, V, Joanne, Van der Vliet, Georgina, Van Tonder, Tina, VanderWeyden, Carrie, Varghese, Jerry, Vaughan, Lachlan, Veale, David, Vickaryyous, Nicky, Vince, Kathryn, Von Welligh, Jacoba, Vora, Sona, Wadehra, Karan, Walker, Rebecca, Walker, Stephen, Wallace, Roslyn, Wallniosve, Stephanie, Wallwork, S., Walmsley, Zoe, Walters, Fiona, Wang, Joyce, Wang, Angela, Wang, Chen, Wanyika, Mercy, Warcel, Dana, Wardrobe, Katrina, Warnes, Kristian, Waterhouse, Christopher, Waterworth, Adam, Watson, Caroline, Watson, Edmund, Watts, Emily, Weaver, Emma, Weber, Nicholas, Webley, Kaytie, Welford, Anna, Wells, Matt, Westbury, Sarah, Westcott, Jackie, Western, Robyn, Weston, Julia, White, Jessica, White, Phillipa, Whitehead, Anna, Whitehouse, James, Wieringa, Samantha, Willan, John, Williams, Sandra, Williams, Bethany, Williamson, Stephanie, Willoughby, Brett, Wilmot, Gail, Wilmott, Rosalind, Wilson, Joanna, Wilson, Emma, Wilson, Suzy, Wilson, Heather, Wilson, Caroline, Wilson, Tanya, Wilton, Margaret, Wiltshire, Paula, Wincup, Joanne, Wolf, Julia, Wong, Henna, Wong, Cyndi, Wong, Daniel, Wong, Jonathan, Wong, Shi Qin, Wood, Sarah, Wood, Henry, Wooding, Jackie, Woolley, Kelly, Wright, Myles, Wynn-Williams, Roland, Yannakou, Costas, Yeoh, Zhi Han, Yeung, David, Young, Agnes, Yuen, Flora, Yuen, Agnes, Zaja, Oliver, Zhang, Xiao-Yin, and Zhang, Mei

Published
2025
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13. Magnetic Seed vs Guidewire Breast Cancer Localization With Magnetic Lymph Node Detection

Author

Pantiora, Eirini, Jazrawi, Allan, Hersi, Abdi-Fatah, Abdsaleh, Shahin, Ahlstedt, Hanna, Molnar, Eva, Wärnberg, Fredrik, Eriksson, Staffan, Karakatsanis, Andreas, Pantiora, Eirini, Jazrawi, Allan, Hersi, Abdi-Fatah, Abdsaleh, Shahin, Ahlstedt, Hanna, Molnar, Eva, Wärnberg, Fredrik, Eriksson, Staffan, and Karakatsanis, Andreas

Abstract

Importance Guidewires have been the standard for breast lesion localization but pose operative and logistic challenges. Paramagnetic seeds have shown promising results, but to the authors’ knowledge, no randomized comparison has been performed. Objective To determine whether the combination of a paramagnetic seed and superparamagnetic iron oxide (SPIO) is equivalent to guidewire and SPIO for breast cancer localization and sentinel lymph node detection (SLND). Design, Setting, and Participants This was a phase 3, pragmatic, equivalence, 2-arm, open-label, randomized clinical trial conducted at 3 university and/or community hospitals in Sweden from May 2018 to May 2022. Included in the study were patients with early breast cancer planned for breast conservation and SLND. Study data were analyzed July to November 2022. Interventions Participants were randomly assigned 1:1 to a paramagnetic seed or a guidewire. All patients underwent SLND with SPIO. Main Outcomes and Measures Re-excision rate and resection ratio (defined as actual resection volume / optimal resection volume). Results A total of 426 women (median [IQR] age, 65 [56-71] years; median [IQR] tumor size, 11 [8-15] mm) were included in the study. The re-excision rate was 2.90% (95% CI, 1.60%-4.80%), and the median (IQR) resection ratio was 1.96 (1.15-3.44). No differences were found between the guidewire and the seed in re-excisions (6 of 211 [2.84%] vs 6 of 209 [2.87%]; difference, −0.03%; 95% CI, −3.20% to 3.20%; P = .99) or resection ratio (median, 1.93; IQR, 1.18-3.43 vs median, 2.01; IQR, 1.11-3.47; P = .70). Overall SLN detection was 98.6% (95% CI, 97.1%-99.4%) with no differences between arms (203 of 207 [98.1%] vs 204 of 206 [99.0%]; difference, −0.9%; 95% CI, −3.6% to 1.8%; P = .72). More failed localizations occurred with the guidewire (21 of 208 [10.1%] vs 4 of 215 [1.9%]; difference, 8.2%; 95% CI, 3.3%-13.2%; P < .001). Median (IQR) time to specimen excision was shorter for the seed (15 [1

Published
2023
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15. Pedagogising Knowledge in Multigrade Roma Schools: Potentials and Tensions of Innovation

Author

Karpati, Andrea, Molnar, Eva D., and Munkacsy, Katalin

Abstract

Low school achievement and frequent dropout of Hungarian Roma students from primary education is mostly an effect of inadequate curriculum content and teaching methodology. Between 2004 and 2011, the UNESCO affiliated Research Centre for Multimedia in Education at Eötvös Loránd University (ELTE University) in Budapest, Hungary coordinated a series of learning experiments partnered with teaching staff and parents to develop developmental programmes using Information and Communication Technology (ICT) to enhance learning motivation and performance through the integration of the mundane knowledge of students and the recontextualised expert knowledge inherent in the national curriculum. Experiments involved primary schools in small villages with Roma student majority. Verbal and visual communication skills were developed through pair and group work during interdisciplinary activities based on music, arts and crafts traditionally present in Roma communities. Our results prove that lack of motivation and perspective, as well as factors resulting in low learning attainment, may be overcome through culturally grounded ICT-supported teaching and learning. Through staff development and curriculum enrichment, the projects also contributed to integration: they supported the continuation of studies of students in secondary level institutions of their choice, a prerequisite for better chances on the labour market or in higher education.

Published
2014
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22. Lovastatin interferes with the infarct size-limiting effect of ischemic preconditioning and postconditioning in rat hearts

Author

Kocsis, Gabriella F., Pipis, Judit, Fekete, Veronika, Kovacs-Simon, Andrea, Odendaal, Louise, Molnar, Eva, Giricz, Zoltan, Janaky, Tamas, van Rooyen, Jacques, Csont, Tamas, and Ferdinandy, Peter

Subjects
Rats -- Diseases, Rats -- Physiological aspects, Rattus -- Diseases, Rattus -- Physiological aspects, Heart -- Medical examination, Lovastatin -- Properties, Protein kinases -- Properties, Coronary heart disease -- Physiological aspects, Biological sciences
Abstract

Statins have been shown to be cardioprotective; however, their interaction with endogenous cardioprotection by ischemic preconditioning and postconditioning is not known. In the present study, we examined if acute and chronic administration of the 3-hydroxy-3-methylglutaryl CoA reductase inhibitor lovastatin affected the infarct size-limiting effect of ischemic preconditioning and postconditioning in rat hearts. Wistar rats were randomly assigned to the following three groups: 1) vehicle (1% methylcellulose per os for 12 days), 2) chronic lovastatin (15 mg.[kg.sup.-1].[day.sup.-1] per os for 12 days), and 3) acute lovastatin (1% methylcellulose per os for 12 days and 50 [micro]mol/1 lovastatin in the perfusate). Hearts isolated from the three groups were either subjected to a nonconditioning (aerobic perfusion followed by 30-min coronary occlusion and 120-min reperfusion, i.e., test ischemia-reperfusion), preconditioning (three intermittent periods of 5-min ischemia-reperfusion cycles before test ischemia-reperfusion), or postconditioning (six cycles of 10-s ischemia-reperfusion after test ischemia) perfusion protocol. Preconditioning and postconditioning significantly decreased infarct size in vehicle-treated hearts. However, preconditioning failed to decrease infarct size in acute lovastatin-treated hearts, but the effect of postconditioning remained unchanged. Chronic lovastatin treatment abolished postconditioning but not preconditioning; however, it decreased infarct size in the nonconditioned group. Myocardial levels of coenzyme Q9 were decreased in both acute and chronic lovastatin-treated rats. Western blot analysis revealed that both acute and chronic lovastatin treatment attenuated the phoshorylation of Akt; however, acute but not chronic lovastatin treatment increased the phosphorylation of p42 MAPK/ERK. We conclude that, although lovastatin may lead to cardioprotection, it interferes with the mechanisms of cardiac adaptation to ischemic stress. coronary occlusion; coenzyme Q9; Akt; p42 mitogen-activated protein kinase/extracellular signal-regulated kinase; statin

Published
2008

25. Effects of pharmaceutically active compounds (PhACs) on fish body and scale shape in natural waters

Author

Staszny, Adam, primary, Dobosy, Peter, additional, Maasz, Gabor, additional, Szalai, Zoltan, additional, Jakab, Gergely, additional, Pirger, Zsolt, additional, Szeberenyi, Jozsef, additional, Molnar, Eva, additional, Pap, Lilianna Olimpia, additional, Juhasz, Vera, additional, Weiperth, Andras, additional, Urbanyi, Bela, additional, Kondor, Attila Csaba, additional, and Ferincz, Arpad, additional

Published
2021
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31. Labour market perspectives of young women living in extreme poverty in closed rural space: the case of a Hungarian-Romanian cul-de-sac border village

Author

Czibere, Ibolya, Molnar, Eva, Czibere, Ibolya, and Molnar, Eva

Abstract

This study presents young uneducated women’s labour market perspectives in a cul-de-sac village of 350 inhabitants near the Hungarian-Romanian border. On the basis of interviews, we investigate this closed rural space where young people start life and make labour market decisions. We examine the most influential factors, and how these are perpetuating poverty and exclusion onto the next generations. Girls and women living here belong to a community that has been excluded from society. Their poverty is not temporary in nature and not exclusively a problem of making a living, but a status solidified into lifestyle. Women do not only receive more limited material resources compared to men, but they also experience disadvantages in areas as crucial as education, work, leisure and social relationships. This is because of life management strategies that reverse into traditionalism. This unfavourable situation does not allow women to make decisions on their lives. It is the family or the male members of the community who make the decisions instead. This includes decisions on education, starting a family, having children, sexuality, contraception, and the labour market., Este estudio presenta las perspectivas laborales de las mujeres jóvenes sin educación en un pueblo fronterizo de 350 habitantes próximo a la frontera húngaro-rumana. Sobre la base de entrevistas, investigamos esta zona rural profunda en la que los jóvenes comienzan su vida y efectúan decisiones laborales. Examinamos los factores más influyentes, y cómo estos están perpetuando la pobreza y la exclusión de cara a las generaciones próximas. Las jóvenes y las mujeres que viven aquí pertenecen a una comunidad que ha sido excluida de la sociedad. Su pobreza no es de naturaleza temporal y no es exclusivamente un problema de ganarse la vida, sino un estatus solidificado en estilo de vida. Las mujeres no sólo reciben recursos materiales más limitados que los hombres, sino que también experimentan desventajas en áreas tan cruciales como la educación, el trabajo, el ocio y las relaciones sociales. Esto se debe a estrategias de gestión vital de corte tradicionalista. Esta situación desfavorable no permite a las mujeres tomar decisiones sobre sus vidas. Son la familia o los varones de la comunidad los que toman las decisiones en su lugar. Esto incluye decisiones sobre la educación, la formación de un hogar, la búsqueda de descendencia, la sexualidad, la contracepción y el mercado laboral.

Published
2017

33. Students and Children Learning from Each Other During a Pediatric Field Trip Program

Author

Molnar, Eva T. and Armstead, Dorothy

Abstract

A field trip program for third-year medical students at Howard University College of Medicine, in existence since 1969, is described. It permits students to observe and evaluate healthy and handicapped children in a non-hospital environment, allows children and students to interact informally, and exposes students to various agency settings in education, rehabilitation, and counseling. (LBH)

Published
1978

34. Utvecklande medarbetarsamtal : – en intervjustudie ur ledarperspektiv

Author

Torstensson, Maria and Molnar, Eva

Subjects
Other Social Sciences not elsewhere specified, Work Sciences, Arbetslivsstudier, Övrig annan samhällsvetenskap
Abstract

denna studie undersöks hur ledare arbetar med medarbetarsamtal för att utvecklamedarbetare och organisationer. Studien har genomförts med utgångspunkt i ledarnasuppfattning om hur de använder medarbetarsamtalet som ett hjälpande verktyg för att få greppom hur medarbetare och organisationen kan arbeta mot samma mål och utveckling. För att tareda på vår fråga har vi använt oss av en kvalitativ undersökningsmetod medsemistrukturerade interjvuer. Vi har pratat med 7 olika ledare som arbetar på två olikaorganisationer. I vår studie har de tillfrågade varit positiva och ansett att medarbetarsamtal ärett viktigt verktyg för att utveckla medarbetare och organisationen men även ett viktigt sätt attfå fram feedback på hur medarbetarena uppfattar ledarna. Det alla ledare hade somgemensamt intresse av att få fram från medarbetarsamtalen var hur medarbetarna mår!Resultatet visar även att det är upp till både ledarna och medarbetarna att var tydliga ochärliga under samtalet för att kunna använda informationen som kommer fram för att kunnaanvända sig av den för framtiden. Det vissar även hur viktigt det är med bra kommunikationoch feedback mellan de olika hierakierna i organisationerna.

Published
2014

35. Obituary of Bela Molnar

Author

Eva T. Molnar Eva T. Molnar

Subjects
media_common.quotation_subject, General Physics and Astronomy, Art, Theology, Obituary, media_common
Published
2009
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36. ELECTROCHEMICAL OXIDATION OF 10H-PHENOTHIAZINE-1-CARBOXYLIC ACID.

Author

SĂCARĂ, ANA-MARIA, CRISTEA, CASTELIA, LOVASZ, TAMAS, PORUMB, DAN, MOLNAR, EVA, and MURESAN, LIANA MARIA

Subjects
PHENOTHIAZINE derivatives, ELECTROCHEMISTRY, OXIDATION, CARBOXYLIC acid derivatives, MALACHITE green, HYDROGEN bonding, CARBON electrodes
Abstract

The electrochemical behavior of 10H-phenothiazine-1-carboxylic acid was investigated by square wave anodic stripping voltammetry (SWASV) at a glassy carbon electrode, which evidenced the first monoelectronic oxidation step at low potentials (around 0.25 V), slightly modulated by the nature of the solvent. The effect of three different solvents (acetonitrile, dimethyl sulfoxide and chloroform) on the strength of intramolecular hydrogen bonding associations was evidenced by DFT calculations. The computed electron density at the heterocyclic nitrogen atom appeared well correlated to the recorded oxidation potential. The possibility to use of 10H-phenothiazine-1-carboxylic acid as potential mediator for electrochemical detection of Malachite Green was explored, but the phenothiazine derivative appeared not suitable for the detection of the dye. [ABSTRACT FROM AUTHOR]

Published
2017
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39. Surfactant-derived Alkylphenolic Compounds in Sewage Effuents and Ambient Waters in Switzerland before and after Risk Reduction Measures

Author

Ahel, Marijan, Molnar, Eva, Ibrić, Slavica, Ruprecht, Claudia, Schaffner, Christian, and Giger, Walter

Subjects
nonionic surfactants, nonylphenol, sewage effluents, natural waters, risk assessment
Abstract

Between 1982 and 1985 nonylphenol polyethoxylates (NPnEO, n=3-20) and their major metabolic products: 4-nonylphenol (NP), 4-nonylphenol monoethoxylate (NP1EO), 4-nonylphenol diethoxylate (NP2EO), nonylphenoxy acetic acid (NP1EC) and nonylphenoxy(ethoxy) acetic acid (NP2EC) were intensively investigated in sewage effluents, sewage sludges, and in ambient waters in Switzerland. Based on the results of these exposure measurements, the use of NPnEO as nonionic surfactants in laundry detergents was banned in 1986 by the Swiss ordinance for environmental pollutants. The detergent manufacturing company voluntarily stopped the addition of NPnEO surfactants to household surface cleaners, but still included them in industrial cleaners and in some other industrial applications. The objective of the study presented here was to evaluate the effect of these legal and voluntary risk reduction measures on the residual levels of nonylphenolic chemicals in municipal wastewaters and in rivers. Enrichment of the NPnEO surfactants (n=3-20) from sewage effluents was carried out by solid-phase extraction using graphitized carbon black (Carbopack B). Enrichment of the lipophilic metabolic products (NP, NP1EO and NP2EO) from secondary sewage effluents and from river water was performed by liquid/liquid extraction with hexane, while NP1EC and NP2EC were extracted using C18 solid-phase extraction. The extracts of NPnEO as well as of the lipophilic metabolites were subsequently analysed by normal-phase HPLC, while NPnEC were analysed by C18 reversed-phase HPLC. Fluorescence detection with wavelengths set at 228 nm for excitation and 305 nm for emission was applied for the analyses of all nonylphenolic compounds considered. Primary sewage effluents of the sewage treatment plant of the city of Zurich contained in October 1997 NPnEO levels around 0.15 mg/L compared to 0.7 - 1.0 mg/L in 1983. Thus, the emission of NPnEO surfactants has been reduced to approximately 10 %. As a consequence, the concentration of different types of NPnEO-metabolites in biologically treated effluents was also significantly reduced. Typical concentration levels of NP found for the Zurich area in 1997/8 were 0.2 - 1.2 ľg/L NP accompanied by NP1EO and NP2EO determined at similar concentrations. Treated waste waters in Eastern Switzerland receiving effluents from textile finishing plants showed elevated levels of NP, and NP1/2EO with maximum concentrations of NP, NP1EO, and NP2EO of 3.5, 5, and 5 ľg/L, respectively. The concentration of nonylphenolic compounds in ambient waters strongly decreased after the 1986 ban. In the Glatt River near Zurich concentrations of NP, NP1EO and NP2EO measured during 1997/8 were in the range of 0.1 - 0.3 ľg/L in comparison to 0.5 - 21 ľg/L in 1983/4. The same type of strong reduction was observed for NPnEC, which decreased from approximately 50 mg/l in 1983/4 to 0.5-5 mg/l in 1998, but remained the predominant nonylphenolic compounds in the river. The risk reduction measures for NPnEO and the improvement of sewage treatment plants have a significant impact on the residual levels found in wastewaters and receiving rivers. The observed attenuation varies considerably. Similarly, the different relative composition found for NP, NP1/2EO and NP1/2EC are probably reflecting differences in the particular wastewater treatment plants and rivers. The reduction of environmental inputs of nonylphenolic compounds could also be detected as it is archived in recent sediments of Swiss lakes. The results of this latter investigation based on dated sediment cores reflected the increased use of NPnEO-surfactants in the early 1960's and a decreased discharge of NP and NP1/2EO after 1986.

Published
1999

41. Nonylphenolic chemicals revisited in Switzerland : monitoring waste water effluents and ambient waters before and after risk reduction measures

Author

Ahel, Marijan, Giger, Walter, Molnar, Eva, Ibrić, Slavica, Ruprecht, Claudia, and Schaffner, Christian

Subjects
nonylphenol polyethoxylates, wastewater, ambient waters
Abstract

Between 1982 and 1985 nonylphenol polyethoxylates and their major metabolic products: 4-nonylphenol (NP), 4-nonylphenol monoethoxylate (NP1EO), 4-nonylphenol diethoxylate (NP2EO), nonylphenoxy acetic acid (NP1EC) and nonylphenoxy(ethoxy) acetic acid (NP2EC) were intensively investigated in sewage effluents, sewage sludges nad in ambient waters in Switzerland.

Published
1998

42. Waschen und Putzen hinterlassen ihre Spuren

Author

Giger, Walter, Molnar, Eva, Ibrić, Slavica, Ruprecht, Claudia, Ahel, Marijan, Schaffner, Christian, and Stoll, Jean-Marc

Subjects
Waschen, Putzen, Tenside, Abwasser
Abstract

Chemikalien aus Wasch- und Reinigungsmitteln gelangen via Abwasserkanalisation teilweise auch in Gewaesser. Bei den nicht-ionischen reinigungsaktiven Substanzen vom Typ Nonylphenolpolyethoxylat und deren Abbauzwischenprodukte stellt sich die Frage, ob die Massnahmen der Eidgenossischen Stoffverordnung von 1986 genuegen.

Published
1998

43. NOVEL 1,9-DIACYL-5- (PHENOTHIAZINYL)DIPYRROMETHANE DIALKYLTIN COMPLEXES.

Author

BREM, BALAZS, GAL, EMESE, GĂINĂ, LUIZA, LOVASZ, TAMAS, MOLNAR, EVA-ANDREA, PORUMB, DAN, and CRISTEA, CASTELIA

Subjects
DIPYRROMETHANES, DIACYLAMINES, FOURIER transform infrared spectroscopy, NUCLEAR magnetic resonance spectroscopy, BUTYLTIN compounds, MASS spectrometry, ETHANES
Abstract

New 1,9-diacyl-5-(phenothiazinyl)dipyrromethane (aphdpm) obtained by diacylation of 5-phenothiazinyl-dipyrromethane were subjected to complexation reactions with dimethyl- and di-n-butyltin(IV) dichloride which afforded complexes of the type [Me2Sn(aphdpm)] and [(n-Bu)2Sn(aphdpm)] respectively [where aphdpm: 1,9-diformyl-5-(phenothiazinyl)dipyrromethane and 1,9-dibenzoyl-5-(phenothiazinyl) dipyrromethane]. Plausible structures of the new tin(IV) complexes were proposed based on spectroscopic FT-IR, 1H-,13C-,119Sn-NMR and mass spectrometry studies. [ABSTRACT FROM AUTHOR]

Published
2016

48. THE LONG-TERM FORECAST OF LAND PASSENGER TRANSPORT RELATED CO2 EMISSION AND ENERGY USE IN HUNGARY.

Author

Andrejszki, Tamas, Torok, Adam, and Molnar, Eva

Subjects
PUBLIC transit, ENERGY consumption, CARBON dioxide mitigation, INVESTMENTS, SUSTAINABLE development
Abstract

Hungary as the part of the European Union has to deal with the reduction of CO2 level. Reaching the 2050 target requires to examine and develop every sector of the emission. Transport has a dynamic and significant part in CO2 emission but generally policymakers do not have the courage to change significantly the modal shift by political decisions because of their popularity. Transport investments are generally long-term investments that show a return in around 30 years. ForFITS is a software tool for policymakers to simulate the effects of different transport scenarios and gives outputs about the transport activity, energy consumption and emission of the next 30 years. Hungary take its' part of the UNDA project as being one of the pilot countries of using ForFITS. After the collection of data different scenarios were made. The aim of this study is to present the most realistic scenario for Hungary especially in the case of passenger transport. [ABSTRACT FROM AUTHOR]

Published
2014
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50. Occurrence and Fate of Macrolide Antibiotics in Wastewater Treatment Plants and in the Clan Valley Watershed, Switzerland.

Author

Mcardell, Christa S., Molnar, Eva, Suter, Marc J.-F., and Giger, Walter

Subjects
*MACROLIDE antibiotics, *SEWAGE disposal plants, *WASTEWATER treatment, *MACROCYCLIC compounds, *REFUSE disposal facilities
Abstract

An analytical method was developed for determining macrolide antibiotics in treated wastewater effluents and in ambient water based on solid-phase extraction and LC/MS analysis as well as on LC/MS/MS for structural confirmation. In wastewater treatment plants (WWTPs) macrolides are only partly eliminated and can therefore reach the aquatic environment. In treated effluents from three WWTPs in Switzerland, clarithromycin, roxithromycin, and erythromycin-H[sub2]0, the main degradation product of erythromycin, were found. The most abundant, clarithromycin, reflects the consumption pattern of macrolide antibiotics. Summer concentrations of clarithromycin varied between 57 and 330 ng/L in treated WWTP effluents. In the WWTP Kloten-Opfikon seasonal differences revealed a load two times higher in winter than in summer. The higher abundance of erythromycin-H20 in the effluent of WWTP Kloten-Opfikon can be explained by distinct consumption patterns due to the main international airport of Switzerland in the catchment area. In the Glatt River clarithromycin reached concentrations of up to 75 ng/L Mass flux determinations in treated effluents and in river water in the Glatt Valley watershed showed that elimination of clarithromycin along the river stretch of 36 km is insignificant (<20%). Investigations in the Glatt River before and after the diversion of the largest WWTP revealed an observable decrease in clarithromycin loads. [ABSTRACT FROM AUTHOR]

Published
2003
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