8 results on '"Molly Bowman"'
Search Results
2. Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
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Zachary Beattie, Thomas Riley, Nora Mattek, Nicole Sharma, Molly Bowman, Katherine Wild, Adriana Seelye, Jeffrey Kaye, Ona Golonka, Christina Reynolds, Johanna Austin, Charlie Quinn, and Jonathan Lee
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Ubiquitous computing ,020205 medical informatics ,Aging in place ,Computer science ,General Chemical Engineering ,Wearable computer ,02 engineering and technology ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Home automation ,Human–computer interaction ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Humans ,Aged ,Monitoring, Physiologic ,Behavior ,030214 geriatrics ,General Immunology and Microbiology ,business.industry ,Computers ,General Neuroscience ,Continuous monitoring ,Loneliness ,Remote Sensing Technology ,Sleep (system call) ,Self Report ,medicine.symptom ,business ,Laboratories ,Independent living - Abstract
An end-to-end suite of technologies has been established for the unobtrusive and continuous monitoring of health and activity changes occurring in the daily life of older adults over extended periods of time. The technology is aggregated into a system that incorporates the principles of being minimally obtrusive, while generating secure, privacy protected, continuous objective data in real-world (home-based) settings for months to years. The system includes passive infrared presence sensors placed throughout the home, door contact sensors installed on exterior doors, connected physiological monitoring devices (such as scales), medication boxes, and wearable actigraphs. Driving sensors are also installed in participants' cars and computer (PC, tablet or smartphone) use is tracked. Data is annotated via frequent online self-report options that provide vital information with regard to the data that is difficult to infer via sensors such as internal states (e.g., pain, mood, loneliness), as well as data referent to activity pattern interpretation (e.g., visitors, rearranged furniture). Algorithms have been developed using the data obtained to identify functional domains key to health or disease activity monitoring, including mobility (e.g., room transitions, steps, gait speed), physiologic function (e.g., weight, body mass index, pulse), sleep behaviors (e.g., sleep time, trips to the bathroom at night), medication adherence (e.g., missed doses), social engagement (e.g., time spent out of home, time couples spend together), and cognitive function (e.g., time on computer, mouse movements, characteristics of online form completion, driving ability). Change detection of these functions provides a sensitive marker for the application in health surveillance of acute illnesses (e.g., viral epidemic) to the early detection of prodromal dementia syndromes. The system is particularly suitable for monitoring the efficacy of clinical interventions in natural history studies of geriatric syndromes and in clinical trials.
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- 2018
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3. Social Markers of Mild Cognitive Impairment: Proportion of Word Counts in Free Conversational Speech
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Jeffrey Kaye, Hiroko H. Dodge, Meysam Asgari, Mattie Gregor, Adriana Seelye, Molly Bowman, Nora Mattek, and Oscar Ybarra
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Male ,medicine.medical_specialty ,Neuropsychological Tests ,Audiology ,Logistic regression ,Article ,050105 experimental psychology ,law.invention ,Developmental psychology ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Alzheimer Disease ,law ,early identification ,Interview, Psychological ,medicine ,Humans ,Speech ,Cognitive Dysfunction ,0501 psychology and cognitive sciences ,Mild cognitive impairment (MCI) ,Social Behavior ,conversational interactions ,Generalized estimating equation ,Aged ,Aged, 80 and over ,05 social sciences ,Cognition ,speech characteristics ,medicine.disease ,social markers ,Confidence interval ,Clinical trial ,Logistic Models ,Neurology ,mild cognitive impairment (MCI) ,Asymptomatic Diseases ,Disease Progression ,Female ,Neurology (clinical) ,Alzheimer's disease ,Psychology ,Biomarkers ,030217 neurology & neurosurgery - Abstract
Background: Detecting early signs of Alzheimer’s disease (AD) and mild cognitive impairment (MCI) during the pre-symptomatic phase is becoming increasingly important for cost-effective clinical trials and also for deriving maximum benefit from currently available treatment strategies. However, distinguishing early signs of MCI from normal cognitive aging is difficult. Biomarkers have been extensively examined as early indicators of the pathological process for AD, but assessing these biomarkers is expensive and challenging to apply widely among pre-symptomatic community dwelling older adults. Here we propose assessment of social markers, which could provide an alternative or complementary and ecologically valid strategy for identifying the pre-symptomatic phase leading to MCI and AD. Methods: The data came from a larger randomized controlled clinical trial (RCT), where we examined whether daily conversational interactions using remote video telecommunications software could improve cognitive functions of older adult participants. We assessed the proportion of words generated by participants out of total words produced by both participants and staff interviewers using transcribed conversations during the intervention trial as an indicator of how two people (participants and interviewers) interact with each other in one-on-one conversations. We examined whether the proportion differed between those with intact cognition and MCI, using first, generalized estimating equations with the proportion as outcome, and second, logistic regression models with cognitive status as outcome in order to estimate the area under ROC curve (ROC AUC). Results: Compared to those with normal cognitive function, MCI participants generated a greater proportion of words out of the total number of words during the timed conversation sessions (p=0.01). This difference remained after controlling for participant age, gender, interviewer and time of assessment (p=0.03). The logistic regression models showed the ROC AUC of identifying MCI (vs. normals) was 0.71 (95% Confidence Interval: 0.54 – 0.89) when average proportion of word counts spoken by subjects was included univariately into the model. Conclusion: An ecologically valid social marker such as the proportion of spoken words produced during spontaneous conversations may be sensitive to transitions from normal cognition to MCI.
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- 2015
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4. Characteristics associated with willingness to participate in a randomized controlled behavioral clinical trial using home-based personal computers and a webcam
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Jian Zhu, Hiroko H. Dodge, Yuriko Katsumata, Mattie Gregor, Katherine Wild, Jeffrey Kaye, Nora Mattek, and Molly Bowman
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Male ,Health Knowledge, Attitudes, Practice ,medicine.medical_treatment ,Medicine (miscellaneous) ,law.invention ,Oregon ,Cognition ,0302 clinical medicine ,Sample recruitment selection bias ,Conversation-based social interaction ,Microcomputers ,Randomized controlled trial ,law ,Surveys and Questionnaires ,Behavioral randomized controlled trial ,Odds Ratio ,Medicine ,Pharmacology (medical) ,030212 general & internal medicine ,Cognitive decline ,Aged, 80 and over ,Attitude to Computers ,Volunteer bias ,Equipment Design ,Middle Aged ,3. Good health ,PC ,Female ,Cognitive function ,Clinical psychology ,Research Subjects ,03 medical and health sciences ,Humans ,Dementia ,Cognitive Dysfunction ,Interpersonal Relations ,Generalizability theory ,Social Behavior ,Aged ,Internet ,Cognitive Behavioral Therapy ,business.industry ,Research ,Patient Selection ,Mild cognitive impairment ,Odds ratio ,medicine.disease ,Webcam ,Clinical trial ,Therapy, Computer-Assisted ,Cognitive therapy ,business ,030217 neurology & neurosurgery - Abstract
Background Trials aimed at preventing cognitive decline through cognitive stimulation among those with normal cognition or mild cognitive impairment are of significant importance in delaying the onset of dementia and reducing dementia prevalence. One challenge in these prevention trials is sample recruitment bias. Those willing to volunteer for these trials could be socially active, in relatively good health, and have high educational levels and cognitive function. These participants’ characteristics could reduce the generalizability of study results and, more importantly, mask trial effects. We developed a randomized controlled trial to examine whether conversation-based cognitive stimulation delivered through personal computers, a webcam and the internet would have a positive effect on cognitive function among older adults with normal cognition or mild cognitive impairment. To examine the selectivity of samples, we conducted a mass mail-in survey distribution among community-dwelling older adults, assessing factors associated with a willingness to participate in the trial. Methods Two thousand mail-in surveys were distributed to retirement communities in order to collect data on demographics, the nature and frequency of social activities, personal computer use and additional health-related variables, and interest in the prevention study. We also asked for their contact information if they were interested in being contacted as potential participants in the trial. Results Of 1,102 surveys returned (55.1% response rate), 983 surveys had complete data for all the variables of interest. Among them, 309 showed interest in the study and provided their contact information (operationally defined as the committed with interest group), 74 provided contact information without interest in the study (committed without interest group), 66 showed interest, but provided no contact information (interest only group), and 534 showed no interest and provided no contact information (no interest group). Compared with the no interest group, the committed with interest group were more likely to be personal computer users (odds ratio (OR) = 2.78), physically active (OR = 1.03) and had higher levels of loneliness (OR = 1.16). Conclusion Increasing potential participants’ familiarity with a personal computer and the internet before trial recruitment could increase participation rates and improve the generalizability of future studies of this type. Trial registration The trial was registered on 29 March 2012 at ClinicalTirals.gov (ID number NCT01571427).
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- 2014
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5. P1‐353: A 6‐WEEK RANDOMIZED CONTROLLED TRIAL TO INCREASE SOCIAL INTERACTIONS USING HOME‐BASED TECHNOLOGIES IMPROVED LANGUAGE‐BASED EXECUTIVE FUNCTION
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Hiroko H. Dodge, Nora Matteck, Jian Zhau, Molly Bowman, Katherine Wild, and Jeffrey Kaye
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medicine.medical_specialty ,Epidemiology ,Health Policy ,media_common.quotation_subject ,Home based ,law.invention ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Randomized controlled trial ,law ,Physical therapy ,medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,Psychology ,Function (engineering) ,media_common - Published
- 2014
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6. P4‐348: SOCIAL BIOMARKERS FOR EARLY SIGNS OF DEMENTIA: INCREASED SPOKEN WORD COUNTS AMONG OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT (MCI)
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Meysam Asgari, Jeffrey Kaye, Oscar Ybarra, Molly Bowman, Mattie Gregor, Nora Matteck, and Hiroko H. Dodge
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Spoken word ,medicine.medical_specialty ,Epidemiology ,Early signs ,Health Policy ,medicine.disease ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,medicine ,Dementia ,Neurology (clinical) ,Geriatrics and Gerontology ,Mild cognitive impairment (MCI) ,Psychology ,Psychiatry - Published
- 2014
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7. P2–320: Characteristics associated with willingness to participate in technology‐based behavioral clinical trials
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Hiroko H. Dodge, Jeffrey Kaye, Mattie Gregor, Kathryn Wild, Molly Bowman, and Katsumata Yuriko
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Clinical trial ,Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,business.industry ,Health Policy ,Medicine ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,Clinical psychology - Published
- 2013
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8. Web-enabled conversational interactions as a method to improve cognitive functions: Results of a 6-week randomized controlled trial
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Jian Zhu, Katherine Wild, Hiroko H. Dodge, Molly Bowman, Jeffrey Kaye, Nora Mattek, Oscar Ybarra, and David A. Loewenstein
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Psychomotor learning ,Internet ,Communication technology ,Oregon Center for Aging and Technology (ORCATECH) ,Clinical Dementia Rating ,Mild cognitive impairment ,Cognition ,Featured Article ,medicine.disease ,Executive functions ,law.invention ,Cognitive test ,Psychiatry and Mental health ,Prevention study ,Randomized controlled trial ,law ,Social engagement ,Conversational interaction ,Randomized controlled clinical trial ,medicine ,Dementia ,Neurology (clinical) ,Mild cognitive impairment (MCI) ,Psychology ,Clinical psychology - Abstract
Introduction Increasing social interaction could be a promising intervention for improving cognitive function. We examined the feasibility of a randomized controlled trial to assess whether conversation-based cognitive stimulation through personal computers, webcams, and a user-friendly interactive Internet interface had high adherence and a positive effect on cognitive function among older adults without dementia. Methods Daily 30-minute face-to-face communications were conducted during a 6-week trial period in the intervention group. The control group received only a weekly telephone interview. The cognitive status of normal subjects and those with mild cognitive impairment was operationally defined as a global clinical dementia rating of 0 and 0.5, respectively. Age, sex, education, mini mental state examination score, and clinical dementia rating score were balancing factors in randomization. The subjects were recruited using mass-mailing invitations. The pre- to postintervention differences in the cognitive test scores and loneliness scores were compared between the control and intervention groups using linear regression models. Results Eighty-three subjects participated (41 in the intervention group and 42 in the control group). Their mean ± standard deviation age was 80.5 ± 6.8 years. Adherence to the protocol was high. There was no dropout and mean percentage of days completed of the targeted trial days among the intervention group was 89% (range 77%–100%). Among the cognitively intact participants, the intervention group improved more than did the control group on a semantic fluency test ( P = .003) at the post-trial assessment and a phonemic fluency test ( P = .004) at the 18-week assessments. Among those with mild cognitive impairment, a trend ( P = .04) toward improved psychomotor speed was observed in the intervention group. Conclusion Daily conversations by way of user-friendly Internet communication programs demonstrated high adherence. Among the cognitively intact, the intervention group showed greater improvement in tests of language-based executive functions. Increasing daily social contacts through communication technologies could offer cost-effective home-based prevention methods. Additional studies with a longer follow-up duration are required to examine whether the intervention slows cognitive declines and delays the onset of dementia.
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