23 results on '"Molkhou JM"'
Search Results
2. [Giant colonic or ileo-jejunal diverticulum and infra-mesocolic abdomial pseudocysts: diagnosis, pathalogical and clinical analysis].
- Author
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Gillion JF, Julles MC, Convard JP, Laroudie M, Balaton A, Karkouche B, Berthelot G, Bonan A, Bonnichon JM, Chollet JM, and Molkhou JM
- Subjects
- Aged, Cysts diagnosis, Cysts surgery, Diagnosis, Differential, Diverticulum, Colon diagnosis, Diverticulum, Colon surgery, Female, Humans, Ileal Diseases diagnosis, Ileal Diseases surgery, Jejunal Diseases diagnosis, Jejunal Diseases surgery, Male, Middle Aged, Tomography, X-Ray Computed, Cysts pathology, Diverticulum, Colon pathology, Ileal Diseases pathology, Jejunal Diseases pathology
- Abstract
Giant diverticula of the small intestine and colon are rare. Four cases treated at our institution in the last year are reported and compared to published cases; specific features and those which differentiate them from abdominal pseudocysts are described. They most commonly present a clinical tableau similar to commonplace diverticular disease. Awareness of this unusual condition and a good CT study are the keys to diagnosis. Giant diverticula may be acquired or congenital. The acquired type is simply a more spectacular version of commonplace diverticulosis while the congenital type, having a muscular wall and myenteric plexus, is more akin to intestinal duplications. Treatment is surgical and, in the case of sigmoid giant diverticula, usually requires a colon resection similar to that required for sigmoid diverticulitis.
- Published
- 2005
- Full Text
- View/download PDF
3. Laparoscopic treatment of acute small bowel obstruction: a multicentre retrospective study.
- Author
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Levard H, Boudet MJ, Msika S, Molkhou JM, Hay JM, Laborde Y, Gillet M, and Fingerhut A
- Subjects
- Acute Disease, Female, Follow-Up Studies, Humans, Intestinal Obstruction mortality, Intestine, Small, Length of Stay statistics & numerical data, Male, Middle Aged, Morbidity, Postoperative Complications epidemiology, Postoperative Complications mortality, Retrospective Studies, Time Factors, Treatment Outcome, Intestinal Obstruction surgery, Laparoscopy
- Abstract
Background: Laparoscopic surgery is thought to promote early recovery and quicker return to bowel function. The objective was to evaluate the rate and predictive factors of success, the causes of failure, the morbidity, and mortality during and after hospitalization, as well as to determine whether laparoscopic treatment of acute small bowel obstruction offers the same benefits as for other laparoscopic procedures., Methods: The records of 308 patients with acute small bowel obstruction treated laparoscopically in 35 centres between 1 October 1988 and 30 September 1996 were retrospectively reviewed., Results: Treatment was implemented completely by laparoscopy ('success' group) in 168 patients (54.6%). Conversion to laparotomy ('failure' group) was required in 140 patients (45.4%; during the same operation in 126 patients and after a median delay of 4 days (range: 1-12 days) in 14 patients). There were significantly more successes in patients with a history of one or two surgical interventions than in those with more than two (56% vs 37%; P < 0.05). There were significantly more successes in patients who had undergone appendectomy only (67/94; 71%) than in patients who (i) had no antecedent surgery (52%; P < 0.05), or (ii) underwent other surgery (33%; P < 0.001). The rate of success was significantly higher (P < 0.001) in patients operated on early (< 24 h) and in patients with bands (54%), than in those with adhesions (31%) or with other causes of obstruction (15%). The median duration of postoperative ileus was significantly shorter in the 'success' group than in the 'failure' group (2 days vs 4 days; P < 0.001). The median duration of postoperative hospital stay was shorter in the 'success' group than in the 'failure' group (4 days vs 10 days; P < 0.001). Fewer immediate wound complications were sustained in the 'success' group than in the 'failure' group (1.2% vs 10.7%; P < 0.001). The total number of immediate or delayed complications and particularly the number of recurrent obstructions after hospitalization as well as the number of deaths did not differ significantly between the two groups., Conclusions: Successful laparoscopic treatment of small bowel obstruction can be expected in patients who are seen early, and who have had one or two previous interventions (particularly appendectomy, especially if bands are found).
- Published
- 2001
- Full Text
- View/download PDF
4. [Pneumococcal peritonitis of gynecologic etiology].
- Author
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Blanche P, Baret M, Si Larbi AG, Molkhou JM, Dazza F, Nguyen TB, Galezowski N, and Herreman G
- Subjects
- Adult, Amoxicillin therapeutic use, Ceftriaxone therapeutic use, Cephalosporins therapeutic use, Female, Follow-Up Studies, Humans, Penicillins therapeutic use, Peritonitis diagnosis, Peritonitis drug therapy, Pneumococcal Infections diagnosis, Pneumococcal Infections drug therapy, Salpingitis diagnosis, Time Factors, Tomography, X-Ray Computed, Peritonitis etiology, Pneumococcal Infections complications, Salpingitis complications
- Published
- 1998
- Full Text
- View/download PDF
5. Omentoplasty in the prevention of anastomotic leakage after colonic or rectal resection: a prospective randomized study in 712 patients. French Associations for Surgical Research.
- Author
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Merad F, Hay JM, Fingerhut A, Flamant Y, Molkhou JM, and Laborde Y
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Anastomosis, Surgical, Female, Humans, Male, Middle Aged, Reoperation, Risk Factors, Treatment Outcome, Colectomy, Colonic Diseases surgery, Omentum surgery, Postoperative Complications prevention & control, Surgical Flaps
- Abstract
Objective: To investigate the role of omentoplasty (OP) in the prevention of anastomotic leakage after colonic or rectal resection., Summary Background Data: It has been proposed that OP--wrapping the omentum around the colonic or rectal anastomosis--reinforces intestinal sutures with the expectation of lowering the rate of anastomotic leakage. However, there are no prospective, randomized trials to date to prove this., Methods: Between September 1989 and March 1994, a total of 705 patients (347 males and 358 females) with a mean age of 66 +/- 15 years (range, 15-101) originating from 20 centers were randomized to undergo either OP (n = 341) or not (NO, n = 364) to reinforce the colonic anastomosis after colectomy. Patients had carcinoma, benign tumor, colonic Crohn's disease, diverticular disease of the sigmoid colon, or another affliction located anywhere from the right colon to and including the midrectum. Patients undergoing emergency surgery were not included. Random allotment took place once the resection and anastomosis had been performed, the surgeon had tested the anastomosis for airtightness, and the omental flap was deemed feasible. Patients were divided into four strata: ileo- or colocolonic anastomosis, supraperitoneal ileo- or colorectal anastomosis, infraperitoneal ileo- or colorectal anastomosis, and ileo- or coloanal anastomosis. The primary end point was anastomotic leakage. Secondary end points included intra- and extraabdominal related morbidity and mortality. Severity of anastomotic leakage was based on the rate of repeat operations and related deaths., Results: Both groups were comparable in terms of preoperative characteristics. Intraoperative findings were similar, except that there were significantly more septic operations and abdominal drainage performed in the NO group (p < 0.05 and p < 0.01, respectively). Thirty-five patients (4.9%) had postoperative anastomotic leakage, 16 in the OP group (4.7%) and 19 in the NO group (5.2%). There were 32 deaths (4.5%), 17 (4.9%) in the OP group and 15 (4.2%) in the NO group. Five patients with anastomotic leakage died (0.8%), 2 of whom had OP. There were 37 repeat operations (30%), 12 (6 in each group) for anastomotic leakage. Repeat operation was associated with fatal outcome in 14% of cases. The rate of these and the other intra- and extraabdominal complications did not differ significantly between the two groups., Conclusion: OP to reinforce colorectal anastomosis decreases neither the rate nor the severity of anastomotic failure.
- Published
- 1998
- Full Text
- View/download PDF
6. [Large calculi of the common bile duct. Value of lithotripsy].
- Author
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Lefebvre JF, Molkhou JM, Bonnel D, Dazza F, and Liguory C
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- Adult, Aged, Aged, 80 and over, Female, Gallstones diagnostic imaging, Humans, Male, Middle Aged, Radiography, Ultrasonography, Gallstones therapy, Lithotripsy methods
- Abstract
Certain stones need to be fragmented before being extracted via endoscopic sphincterotomy (ES). From April 1988 to December 1991, extracorporeal lithotripsy was used in this indication in 28 patients (22 females, 6 males) with a mean age of 77 +/- 20 years, using an ultrasound-guided electrohydraulic lithotriptor. Stone detection was performed after perfusion of the nasogastric tube and was easy in 20 cases (71%), difficult in 6 cases (22%) and impossible in 2 cases (7%), which could not be treated by this method. The patients had an average of 1.4 +/- 0.9 stones measuring 19.6 +/- 8 mm and received an average of 2.480 +/- 580 shock waves in a single session for 24 patients and in two sessions for 2 patients. Radiologically obvious fragmentation was achieved in 11 out of 26 cases (42%) and was found to be effective at a further extraction attempt in 4 other cases. Complete clearance of the common bile duct was achieved in 15 cases (57.7%). The size of the stones (> or < 20 mm) and the solitary or multiple nature of the stones did not significantly influence the fragmentation results. No complication related to the technique was observed apart from the constant development of cutaneous petechiae. An improvement in the power of the generator and the use of fluoroscopic rather than ultrasonographic guidance should allow an improvement of these results in the future. Because of its safety, this lithotripsy method can be proposed following failure of mechanical lithotripsy.
- Published
- 1994
7. [Cancer of the exocrine pancreas: where are we on treatment?].
- Author
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Huguier M, Billebaud T, and Molkhou JM
- Subjects
- Antineoplastic Combined Chemotherapy Protocols, Combined Modality Therapy, Humans, Pancreatic Neoplasms radiotherapy, Pancreatic Neoplasms surgery, Pancreatic Neoplasms therapy
- Published
- 1984
8. [Rectal angiodysplasia].
- Author
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Pradel E, de la Lande P, Molkhou JM, Fournier P, Vuong PN, and Dazza FE
- Subjects
- Adult, Female, Gastrointestinal Hemorrhage etiology, Humans, Male, Middle Aged, Veins, Blood Vessels abnormalities, Rectum blood supply
- Abstract
We report 6 cases of rectal angiodysplasia. 2 patients were treated successfully laser coagulation.
- Published
- 1989
9. [Lower digestive tract hemorrhage in the adult].
- Author
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Molkhou JM and Huguier M
- Subjects
- Adolescent, Adult, Aged, Gastrointestinal Hemorrhage etiology, Gastrointestinal Hemorrhage therapy, Humans, Middle Aged, Gastrointestinal Hemorrhage diagnosis
- Published
- 1982
10. [Budd-Chiari syndrome with thrombosis of the inferior vena cava. Treatment by mesenterico-innominate shunt].
- Author
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Hay JM, Molkhou JM, Soubrane O, Valayer J, Parmentier G, Lévy D, Alagille D, and Maillard JN
- Subjects
- Adult, Anastomosis, Surgical, Budd-Chiari Syndrome complications, Child, Female, Humans, Male, Thrombosis surgery, Brachiocephalic Veins surgery, Budd-Chiari Syndrome surgery, Mesenteric Veins surgery, Vena Cava, Inferior
- Abstract
We report two cases of patients, 12 and 28 years old, suffering from a Budd-Chiari syndrome with a thrombosed inferior vena cava, who were treated by a shunt interposed between the superior mesenteric vein and the left innominate vein. The aim of this shunt was to avoid pericardiotomy in these patients with peroperative ascites, in order to reduce the risk of pericarditis after surgery. A reinforced polytetrafluoroethylene prosthesis (Gore-Tex) was used, associated with an interposition jugular vein graft in the 12-year old child, alone in the other case. The left innominate vein was isolated through a midline sternotomy, and the prosthesis was placed in a retrosternal position. Operation and postoperative course were uneventful. All signs of ascites disappeared. The patients were free of symptoms, 8 and 4 months after surgery respectively. Shunt patency was documented by angiography and magnetic nuclear resonance.
- Published
- 1988
11. [Radiotherapy in adenocarcinoma of the rectum. Results].
- Author
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Billebaud T, Molkhou JM, Houry S, Lacaine F, and Huguier M
- Subjects
- Adenocarcinoma pathology, Adenocarcinoma surgery, Brachytherapy methods, Combined Modality Therapy, Follow-Up Studies, Humans, Lymphatic Metastasis, Neoplasm Recurrence, Local radiotherapy, Palliative Care, Prospective Studies, Radiotherapy Dosage, Rectal Neoplasms pathology, Rectal Neoplasms surgery, Adenocarcinoma radiotherapy, Rectal Neoplasms radiotherapy
- Published
- 1985
12. [Mucosecreting tumors of the appendix. 3 cases].
- Author
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Alexandre JH, Billebaud T, Molkhou JM, and Guettier C
- Subjects
- Aged, Appendiceal Neoplasms pathology, Appendiceal Neoplasms surgery, Cystadenocarcinoma metabolism, Cystadenocarcinoma pathology, Cystadenocarcinoma surgery, Cystadenoma diagnosis, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Mucocele diagnosis, Peritonitis etiology, Prognosis, Ultrasonography, Appendiceal Neoplasms metabolism, Mucus metabolism
- Abstract
The three cases reported here illustrate the diagnostic, therapeutic and prognostic problems raised by these tumours. These are rare lesions with little suggestive symptoms, which explains why they are exceptionally diagnosed before surgery. Mucosal hyperplasias and cystadenomas are benign formations with a 90-100% survival rate 5 years after appendicectomy, even when non-cellular mucoid effusion is present. Cystadenocarcinomas are malignant tumours with mucoid secretion containing epithelial cells; they have a tendency to recur despite repeated evacuations, and their 5-year survival rate is approximately 25%; death results from intestinal obstruction or compression of intra-abdominal viscera by the mucoid substance.
- Published
- 1984
13. [Ifenprodil tartrate in the treatment of occlusive arteriopathies of the lower limbs. Results of a prospective double-blind controlled multicenter trial].
- Author
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Natali J, Kieny R, Le Bas P, Benhamou M, and Molkhou JM
- Subjects
- Double-Blind Method, Female, Humans, Male, Middle Aged, Multicenter Studies as Topic, Prospective Studies, Random Allocation, Arterial Occlusive Diseases drug therapy, Leg blood supply, Piperidines therapeutic use, Vasodilator Agents therapeutic use
- Published
- 1989
14. [How to write an article?].
- Author
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Huguier M, Molkhou JM, Houry S, and Lacaine F
- Subjects
- Writing
- Published
- 1989
15. [Pancreatic cystadenocarcinomas. Apropos of a case and review of the literature].
- Author
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Alexandre JH, Billebaud T, Molkhou JM, Soubielle C, and Laget JL
- Subjects
- Cystadenocarcinoma surgery, Humans, Male, Middle Aged, Pancreatic Neoplasms surgery, Prognosis, Cystadenocarcinoma diagnosis, Pancreatic Neoplasms diagnosis
- Abstract
A patient with a pancreatic cystadenocarcinoma was treated initially for a false pancreatic cyst by means of a Y loop, and then by total pancreatectomy three weeks later. Although the prognosis for these tumors amongst the group of pancreatic carcinomas is usually greatly improved, the patient died 6 months after detection of the lesion. However, a literature review also suggested possible prolonged survival in these cases when the tumors are discovered early enough and local or regional spread is absent: wide excision of the tumor without the need for total pancreatectomy may then be sufficient. The "false cyst" appearance frequently taken by this slowly progressing malignant affection has to be emphasized, as well as the need for the renewed classification of these tumors: serous cystadenomas are always benign and must be separated from mucinous cystadenomas that are malignant or are potentially malignant. A CT scan appears to be the investigational procedure providing the most accurate data for determining the limits of surgical excision.
- Published
- 1984
16. [Cancer of the pancreas. Treatment of choice?].
- Author
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Billebaud T, Molkhou JM, and Huguier M
- Subjects
- Antineoplastic Combined Chemotherapy Protocols therapeutic use, Humans, Pancreatectomy, Pancreatic Neoplasms drug therapy, Pancreatic Neoplasms radiotherapy, Radiotherapy Dosage, Pancreatic Neoplasms surgery
- Published
- 1984
17. [Detection of hepatic metastasis of digestive cancers. Value of enzyme assays and ultrasonography].
- Author
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Molkhou JM, Lacaine F, Houry S, and Huguier M
- Subjects
- Alkaline Phosphatase blood, Aspartate Aminotransferases blood, Female, Humans, L-Lactate Dehydrogenase blood, Liver Neoplasms diagnosis, Male, ROC Curve, gamma-Glutamyltransferase blood, Clinical Enzyme Tests, Digestive System Neoplasms, Liver Neoplasms secondary, Ultrasonography
- Abstract
Alkaline phosphatase (AP), gamma-glutamyl transpeptidase (GGT), lactate dehydrogenase (LDH) and aspartate aminotransferase (AsT) assays, as well as ultrasonography are the easiest and least expensive examinations to perform in the diagnosis of hepatic metastases. The 273 patients included in this series had cancer of the digestive tract. The diagnosis of presence or absence of liver metastases was made at surgery and was positive in 38 patients (14 per cent). A receiver operating characteristic (ROC) curve was drawn after computing the sensitivity (Se) and specificity (Sp) of each laboratory determination while the threshold indicating that the value was normal was incremented. The examinations were then compared in terms of Se, Sp, positive predictive value and negative predictive value. The threshold was determined on the ROC curve where less false-positive and more true-positive results were shown. According to predictive values, laboratory determinations could be classified in decreasing order of usefulness as: AP, LDH, GGT and AsT. Ultrasonography had a positive predictive value of 68 per cent a negative predictive value of 95 per cent, both figures being higher than those of any laboratory examination. These results suggest that ultrasonography has a higher diagnostic value than any of the enzyme assays in the detection of hepatic metastases. Moreover, ultrasonography provides morphological information which, in case of liver resection, may be useful to the surgeon.
- Published
- 1989
18. [Lower digestive hemorrhage in adults. Epidemiology and diagnostic approach. Retrospective analysis of a series of 147 consecutive cases].
- Author
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Molkhou JM, Hay JM, Lacaine F, and Maillard JN
- Subjects
- Adolescent, Adult, Aged, Emergencies, Female, Gastrointestinal Hemorrhage mortality, Humans, Male, Middle Aged, Recurrence, Retrospective Studies, Gastrointestinal Hemorrhage etiology
- Published
- 1986
19. Treatment of rectal prolapse by Delorme's operation.
- Author
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Houry S, Lechaux JP, Huguier M, and Molkhou JM
- Subjects
- Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Middle Aged, Mucous Membrane surgery, Recurrence, Suture Techniques, Rectal Prolapse surgery, Rectum surgery
- Abstract
Rectopexy in the sacral hollow or to the promontory with synthetic material is the most efficient method of reducing and fixing a complete rectal prolapse. However, this distressing condition occurs frequently in elderly patients, often with high operative risk. In these some surgeons have advocated a perineal approach. Eighteen female patients (mean age 74 years) with complete rectal prolapse have been treated by a modified Delorme's procedure which involves a mucosal stripping of the prolapse and longitudinal plication of the muscular wall of the rectum. There was no postoperative mortality or morbidity. After a mean follow-up of 18 months, two complete recurrences occurred. These were treated by the same technique with a good result at 3 years. One other patient presented a partial and intermittent recurrence. Incontinence has improved in four patients and was not made worse in the others. Our results and those previously published show that this procedure is safe in elderly high risk patients considered too unfit for transabdominal surgery.
- Published
- 1987
- Full Text
- View/download PDF
20. Povidone-iodine enema as a preoperative bowel preparation for colorectal surgery. A bacteriologic study.
- Author
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Hay JM, Boussougant Y, Lacaine F, Régnard JF, Molkhou JM, Roverselli D, and Fingerhut A
- Subjects
- Colon surgery, Humans, Metronidazole administration & dosage, Metronidazole pharmacology, Povidone-Iodine administration & dosage, Rectum surgery, Water administration & dosage, Bacteria, Aerobic drug effects, Bacteria, Anaerobic drug effects, Colon microbiology, Enema, Intestinal Mucosa microbiology, Povidone analogs & derivatives, Povidone-Iodine pharmacology, Preoperative Care, Rectum microbiology
- Abstract
To evaluate the effects of povidone-iodine (PI) enema on the bacterial flora of colorectal mucosa, the authors studied 113 patients who were candidates for colorectal surgery. The study of the rectum included 72 patients. Total bacterial concentrations after a PI enema (N = 44) were significantly lower than after a simple water enema (N = 12, P less than 0.001), or than after a water enema associated with intravenous metronidazole (N = 16, P less than 0.01). The study of the colon included 41 patients. Total bacterial concentrations did not differ after a PI enema (N = 24) than after a water enema (N = 11); both groups were associated with intravenous metronidazole. In contrast, both preparations significantly reduced bacterial concentrations when compared with oral administration of polyethyleneglycol (N = 6, P less than 0.01). Similar results were observed in rectal and colonic studies, when analysis was restricted to the anaerobic flora. PI is an antiseptic that, when administered alone in an enema or in association with metronidazole, significantly reduces bacterial concentrations in the mucosa of the colon and rectum. It may be proposed as a simple preoperative preparation for colorectal surgery.
- Published
- 1989
- Full Text
- View/download PDF
21. [Medical writing].
- Author
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Huguier M and Molkhou JM
- Subjects
- Literature, Medicine, Publishing, Writing
- Published
- 1986
22. [Should preventive antibiotics be prescribed in surgery of the appendix, biliary tract, stomach and duodenum?].
- Author
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Molkhou JM, Billebaud T, Houry S, and Huguier M
- Subjects
- Biliary Tract Surgical Procedures, Cefazolin therapeutic use, Cephalosporins therapeutic use, Clinical Trials as Topic, Humans, Metronidazole therapeutic use, Postoperative Complications prevention & control, Prospective Studies, Risk, Anti-Bacterial Agents therapeutic use, Appendectomy adverse effects, Duodenum surgery, Premedication, Stomach surgery
- Abstract
Most infections occurring after biliary or gastrointestinal surgery are caused by dissemination of organisms present in the lumen of the biliary or the gastrointestinal tract at the time of operation. Randomized prospective studies have been performed with antibiotics active against organisms usually found in wound infections. Results have shown that cephalosporin, lincosamide and imidazole in appendicectomy, aminoside, cephalosporin, lincosamide and sulfamide in biliary surgery, and cephalosporin in gastro-duodenal surgery decreased wound infections. These results and prediction of wound sepsis following operations suggest a discriminate use of antibiotic prophylaxis in appendicectomy, gastro-duodenal and biliary tract surgery.
- Published
- 1983
23. [Lower digestive hemorrhage in adults. Diagnosis and management].
- Author
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Molkhou JM, Lacaine F, and Huguier M
- Subjects
- Adult, Gastrointestinal Hemorrhage etiology, Gastrointestinal Hemorrhage therapy, Humans, Colonic Diseases complications, Gastrointestinal Hemorrhage diagnosis, Rectal Diseases complications
- Published
- 1985
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