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1. Revised criteria for the diagnosis and staging of Alzheimer’s disease

Author

Jack, Jr, Clifford R., Andrews, Scott J., Beach, Thomas G., Buracchio, Teresa, Dunn, Billy, Graf, Ana, Hansson, Oskar, Ho, Carole, Jagust, William, McDade, Eric, Molinuevo, Jose Luis, Okonkwo, Ozioma C., Pani, Luca, Rafii, Michael S., Scheltens, Philip, Siemers, Eric, Snyder, Heather M., Sperling, Reisa, Teunissen, Charlotte E., and Carrillo, Maria C.

Published
2024
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2. Where is VALDO? VAscular Lesions Detection and segmentatiOn challenge at MICCAI 2021

Author

Sudre, Carole H., Van Wijnen, Kimberlin, Dubost, Florian, Adams, Hieab, Atkinson, David, Barkhof, Frederik, Birhanu, Mahlet A., Bron, Esther E., Camarasa, Robin, Chaturvedi, Nish, Chen, Yuan, Chen, Zihao, Chen, Shuai, Dou, Qi, Evans, Tavia, Ezhov, Ivan, Gao, Haojun, Sanguesa, Marta Girones, Gispert, Juan Domingo, Anson, Beatriz Gomez, Hughes, Alun D., Ikram, M. Arfan, Ingala, Silvia, Jaeger, H. Rolf, Kofler, Florian, Kuijf, Hugo J., Kutnar, Denis, Lee, Minho, Li, Bo, Lorenzini, Luigi, Menze, Bjoern, Molinuevo, Jose Luis, Pan, Yiwei, Puybareau, Elodie, Rehwald, Rafael, Su, Ruisheng, Shi, Pengcheng, Smith, Lorna, Tillin, Therese, Tochon, Guillaume, Urien, Helene, van der Velden, Bas H. M., van der Velpen, Isabelle F., Wiestler, Benedikt, Wolters, Frank J., Yilmaz, Pinar, de Groot, Marius, Vernooij, Meike W., and de Bruijne, Marleen

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Artificial Intelligence
Abstract

Imaging markers of cerebral small vessel disease provide valuable information on brain health, but their manual assessment is time-consuming and hampered by substantial intra- and interrater variability. Automated rating may benefit biomedical research, as well as clinical assessment, but diagnostic reliability of existing algorithms is unknown. Here, we present the results of the \textit{VAscular Lesions DetectiOn and Segmentation} (\textit{Where is VALDO?}) challenge that was run as a satellite event at the international conference on Medical Image Computing and Computer Aided Intervention (MICCAI) 2021. This challenge aimed to promote the development of methods for automated detection and segmentation of small and sparse imaging markers of cerebral small vessel disease, namely enlarged perivascular spaces (EPVS) (Task 1), cerebral microbleeds (Task 2) and lacunes of presumed vascular origin (Task 3) while leveraging weak and noisy labels. Overall, 12 teams participated in the challenge proposing solutions for one or more tasks (4 for Task 1 - EPVS, 9 for Task 2 - Microbleeds and 6 for Task 3 - Lacunes). Multi-cohort data was used in both training and evaluation. Results showed a large variability in performance both across teams and across tasks, with promising results notably for Task 1 - EPVS and Task 2 - Microbleeds and not practically useful results yet for Task 3 - Lacunes. It also highlighted the performance inconsistency across cases that may deter use at an individual level, while still proving useful at a population level.

Published
2022

4. Where is VALDO? VAscular Lesions Detection and segmentatiOn challenge at MICCAI 2021

Author

Sudre, Carole H., Van Wijnen, Kimberlin, Dubost, Florian, Adams, Hieab, Atkinson, David, Barkhof, Frederik, Birhanu, Mahlet A., Bron, Esther E., Camarasa, Robin, Chaturvedi, Nish, Chen, Yuan, Chen, Zihao, Chen, Shuai, Dou, Qi, Evans, Tavia, Ezhov, Ivan, Gao, Haojun, Girones Sanguesa, Marta, Gispert, Juan Domingo, Gomez Anson, Beatriz, Hughes, Alun D., Ikram, M. Arfan, Ingala, Silvia, Jaeger, H. Rolf, Kofler, Florian, Kuijf, Hugo J., Kutnar, Denis, Lee, Minho, Li, Bo, Lorenzini, Luigi, Menze, Bjoern, Molinuevo, Jose Luis, Pan, Yiwei, Puybareau, Elodie, Rehwald, Rafael, Su, Ruisheng, Shi, Pengcheng, Smith, Lorna, Tillin, Therese, Tochon, Guillaume, Urien, Hélène, van der Velden, Bas H.M., van der Velpen, Isabelle F., Wiestler, Benedikt, Wolters, Frank J., Yilmaz, Pinar, de Groot, Marius, Vernooij, Meike W., and de Bruijne, Marleen

Published
2024
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5. The influence of diversity on the measurement of functional impairment: An international validation of the Amsterdam IADL Questionnaire in 8 countries

Author

Dubbelman, Mark A., Verrijp, Merike, Facal, David, Sánchez-Benavides, Gonzalo, Brown, Laura J. E., van der Flier, Wiesje M., Jokinen, Hanna, Lee, Athene, Leroi, Iracema, Lojo-Seoane, Cristina, Milosevic, Vuk, Molinuevo, José Luís, Rozas, Arturo X. Pereiro, Ritchie, Craig, Salloway, Stephen, Stringer, Gemma, Zygouris, Stelios, Dubois, Bruno, Epelbaum, Stéphane, Scheltens, Philip, and Sikkes, Sietske A. M.

Subjects
Quantitative Biology - Neurons and Cognition, Statistics - Applications
Abstract

INTRODUCTION: To understand the potential influence of diversity on the measurement of functional impairment in dementia, we aimed to investigate possible bias caused by age, gender, education, and cultural differences. METHODS: 3,571 individuals (67.1 {\pm} 9.5 years old, 44.7% female) from the Netherlands, Spain, France, United States, United Kingdom, Greece, Serbia and Finland were included. Functional impairment was measured using the Amsterdam IADL Questionnaire. Item bias was assessed using differential item functioning (DIF) analysis. RESULTS: There were some differences in activity endorsement. A few items showed statistically significant DIF. However, there was no evidence of meaningful item bias: effect sizes were low ({\Delta}R2 range 0-0.03). Impact on total scores was minimal. DISCUSSION: The results imply a limited bias for age, gender, education and culture in the measurement of functional impairment. This study provides an important step in recognizing the potential influence of diversity on primary outcomes in dementia research.

Published
2019
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7. Voxelwise nonlinear regression toolbox for neuroimage analysis: Application to aging and neurodegenerative disease modeling

Author

Puch, Santi, Aduriz, Asier, Casamitjana, Adrià, Vilaplana, Veronica, Petrone, Paula, Operto, Grégory, Cacciaglia, Raffaele, Skouras, Stavros, Falcon, Carles, Molinuevo, José Luis, and Gispert, Juan Domingo

Subjects
Statistics - Machine Learning, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Learning, Quantitative Biology - Neurons and Cognition, Statistics - Applications
Abstract

This paper describes a new neuroimaging analysis toolbox that allows for the modeling of nonlinear effects at the voxel level, overcoming limitations of methods based on linear models like the GLM. We illustrate its features using a relevant example in which distinct nonlinear trajectories of Alzheimer's disease related brain atrophy patterns were found across the full biological spectrum of the disease. The open-source toolbox presented in this paper is available at https://github.com/imatge-upc/VNeAT., Comment: 4 pages + 1 page for acknowledgements and references. NIPS 2016 Workshop on Machine Learning for Health (NIPS ML4HC)

Published
2016

8. The Open-Access European Prevention of Alzheimer’s Dementia (EPAD) MRI dataset and processing workflow

Author

Lorenzini, Luigi, Ingala, Silvia, Wink, Alle Meije, Kuijer, Joost P.A., Wottschel, Viktor, Dijsselhof, Mathijs, Sudre, Carole H., Haller, Sven, Molinuevo, José Luis, Gispert, Juan Domingo, Cash, David M., Thomas, David L., Vos, Sjoerd B., Prados, Ferran, Petr, Jan, Wolz, Robin, Palombit, Alessandro, Schwarz, Adam J., Chételat, Gaël, Payoux, Pierre, Di Perri, Carol, Wardlaw, Joanna M., Frisoni, Giovanni B., Foley, Christopher, Fox, Nick C., Ritchie, Craig, Pernet, Cyril, Waldman, Adam, Barkhof, Frederik, and Mutsaerts, Henk J.M.M.

Published
2022
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9. NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease

Author

Jack, Clifford R, Bennett, David A, Blennow, Kaj, Carrillo, Maria C, Dunn, Billy, Haeberlein, Samantha Budd, Holtzman, David M, Jagust, William, Jessen, Frank, Karlawish, Jason, Liu, Enchi, Molinuevo, Jose Luis, Montine, Thomas, Phelps, Creighton, Rankin, Katherine P, Rowe, Christopher C, Scheltens, Philip, Siemers, Eric, Snyder, Heather M, Sperling, Reisa, Contributors, Elliott, Cerise, Masliah, Eliezer, Ryan, Laurie, and Silverberg, Nina

Subjects
Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Clinical Research, Aging, Alzheimer's Disease, Neurodegenerative, Prevention, Acquired Cognitive Impairment, Dementia, Brain Disorders, Neurosciences, Neurological, Alzheimer Disease, Animals, Biomarkers, Brain, Humans, National Institute on Aging (U.S.), United States, Alzheimer's disease diagnosis, Preclinical Alzheimer's disease, Biomarkers Alzheimer's disease, CSF biomarkers Alzheimer's disease, Alzheimer's disease imaging, Amyloid PET, Tau PET, Contributors, Clinical Sciences, Geriatrics
Abstract

In 2011, the National Institute on Aging and Alzheimer's Association created separate diagnostic recommendations for the preclinical, mild cognitive impairment, and dementia stages of Alzheimer's disease. Scientific progress in the interim led to an initiative by the National Institute on Aging and Alzheimer's Association to update and unify the 2011 guidelines. This unifying update is labeled a "research framework" because its intended use is for observational and interventional research, not routine clinical care. In the National Institute on Aging and Alzheimer's Association Research Framework, Alzheimer's disease (AD) is defined by its underlying pathologic processes that can be documented by postmortem examination or in vivo by biomarkers. The diagnosis is not based on the clinical consequences of the disease (i.e., symptoms/signs) in this research framework, which shifts the definition of AD in living people from a syndromal to a biological construct. The research framework focuses on the diagnosis of AD with biomarkers in living persons. Biomarkers are grouped into those of β amyloid deposition, pathologic tau, and neurodegeneration [AT(N)]. This ATN classification system groups different biomarkers (imaging and biofluids) by the pathologic process each measures. The AT(N) system is flexible in that new biomarkers can be added to the three existing AT(N) groups, and new biomarker groups beyond AT(N) can be added when they become available. We focus on AD as a continuum, and cognitive staging may be accomplished using continuous measures. However, we also outline two different categorical cognitive schemes for staging the severity of cognitive impairment: a scheme using three traditional syndromal categories and a six-stage numeric scheme. It is important to stress that this framework seeks to create a common language with which investigators can generate and test hypotheses about the interactions among different pathologic processes (denoted by biomarkers) and cognitive symptoms. We appreciate the concern that this biomarker-based research framework has the potential to be misused. Therefore, we emphasize, first, it is premature and inappropriate to use this research framework in general medical practice. Second, this research framework should not be used to restrict alternative approaches to hypothesis testing that do not use biomarkers. There will be situations where biomarkers are not available or requiring them would be counterproductive to the specific research goals (discussed in more detail later in the document). Thus, biomarker-based research should not be considered a template for all research into age-related cognitive impairment and dementia; rather, it should be applied when it is fit for the purpose of the specific research goals of a study. Importantly, this framework should be examined in diverse populations. Although it is possible that β-amyloid plaques and neurofibrillary tau deposits are not causal in AD pathogenesis, it is these abnormal protein deposits that define AD as a unique neurodegenerative disease among different disorders that can lead to dementia. We envision that defining AD as a biological construct will enable a more accurate characterization and understanding of the sequence of events that lead to cognitive impairment that is associated with AD, as well as the multifactorial etiology of dementia. This approach also will enable a more precise approach to interventional trials where specific pathways can be targeted in the disease process and in the appropriate people.

Published
2018

10. Amyloid-β positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume

Author

Sánchez-Benavides, Gonzalo, Suárez-Calvet, Marc, Milà-Alomà, Marta, Arenaza-Urquijo, Eider M., Grau-Rivera, Oriol, Operto, Grégory, Gispert, Juan Domingo, Vilor-Tejedor, Natalia, Sala-Vila, Aleix, Crous-Bou, Marta, González-de-Echávarri, José Maria, Minguillon, Carolina, Fauria, Karine, Simon, Maryline, Kollmorgen, Gwendlyn, Zetterberg, Henrik, Blennow, Kaj, and Molinuevo, José Luis

Published
2021
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12. Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup.

Author

Jack, Clifford R., Andrews, J. Scott, Beach, Thomas G., Buracchio, Teresa, Dunn, Billy, Graf, Ana, Hansson, Oskar, Ho, Carole, Jagust, William, McDade, Eric, Molinuevo, Jose Luis, Okonkwo, Ozioma C., Pani, Luca, Rafii, Michael S., Scheltens, Philip, Siemers, Eric, Snyder, Heather M., Sperling, Reisa, Teunissen, Charlotte E., and Carrillo, Maria C.

Abstract

The National Institute on Aging and the Alzheimer's Association convened three separate work groups in 2011 and single work groups in 2012 and 2018 to create recommendations for the diagnosis and characterization of Alzheimer's disease (AD). The present document updates the 2018 research framework in response to several recent developments. Defining diseases biologically, rather than based on syndromic presentation, has long been standard in many areas of medicine (e.g., oncology), and is becoming a unifying concept common to all neurodegenerative diseases, not just AD. The present document is consistent with this principle. Our intent is to present objective criteria for diagnosis and staging AD, incorporating recent advances in biomarkers, to serve as a bridge between research and clinical care. These criteria are not intended to provide step‐by‐step clinical practice guidelines for clinical workflow or specific treatment protocols, but rather serve as general principles to inform diagnosis and staging of AD that reflect current science. Highlights: We define Alzheimer's disease (AD) to be a biological process that begins with the appearance of AD neuropathologic change (ADNPC) while people are asymptomatic. Progression of the neuropathologic burden leads to the later appearance and progression of clinical symptoms.Early‐changing Core 1 biomarkers (amyloid positron emission tomography [PET], approved cerebrospinal fluid biomarkers, and accurate plasma biomarkers [especially phosphorylated tau 217]) map onto either the amyloid beta or AD tauopathy pathway; however, these reflect the presence of ADNPC more generally (i.e., both neuritic plaques and tangles).An abnormal Core 1 biomarker result is sufficient to establish a diagnosis of AD and to inform clinical decision making throughout the disease continuum.Later‐changing Core 2 biomarkers (biofluid and tau PET) can provide prognostic information, and when abnormal, will increase confidence that AD is contributing to symptoms.An integrated biological and clinical staging scheme is described that accommodates the fact that common copathologies, cognitive reserve, and resistance may modify relationships between clinical and biological AD stages. [ABSTRACT FROM AUTHOR]

Published
2024
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14. CSF cutoffs for MCI due to AD depend on APOEε4 carrier status

Author

Marizzoni, Moira, Ferrari, Clarissa, Babiloni, Claudio, Albani, Diego, Barkhof, Frederik, Cavaliere, Libera, Didic, Mira, Forloni, Gianluigi, Fusco, Federica, Galluzzi, Samantha, Hensch, Tilman, Jovicich, Jorge, Marra, Camillo, Molinuevo, José Luis, Nobili, Flavio, Parnetti, Lucilla, Payoux, Pierre, Ranjeva, Jean-Philippe, Ribaldi, Federica, Rolandi, Elena, Rossini, Paolo Maria, Salvatore, Marco, Soricelli, Andrea, Tsolaki, Magda, Visser, Pieter Jelle, Wiltfang, Jens, Richardson, Jill C., Bordet, Régis, Blin, Olivier, and Frisoni, Giovanni B.

Published
2020
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15. The characterisation of subjective cognitive decline

Author

Jessen, Frank, Amariglio, Rebecca E, Buckley, Rachel F, van der Flier, Wiesje M, Han, Ying, Molinuevo, José Luis, Rabin, Laura, Rentz, Dorene M, Rodriguez-Gomez, Octavio, Saykin, Andrew J, Sikkes, Sietske A M, Smart, Colette M, Wolfsgruber, Steffen, and Wagner, Michael

Published
2020
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16. Pathophysiological mechanisms of grey matter morphometry changes in preclinical Alzheimer’s disease

Author

Pelkmans, Wiesje, primary, Cacciaglia, Raffaele, additional, Salvadó, Gemma, additional, Falcon, Carles, additional, Minguillón, Carolina, additional, Fauria, Karine, additional, Kollmorgen, Gwendlyn, additional, Carboni, Margherita, additional, Molinuevo, Jose Luis, additional, Grau‐Rivera, Oriol, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Suarez‐Calvet, Marc, additional, and Gispert, Juan Domingo, additional

Published
2023
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17. Sleep fragmentation is associated with lower cerebral structural integrity in females

Author

Stankeviciute, Laura, primary, Tort‐Colet, Núria, additional, Fernández‐Arcos, Ana, additional, Garcia, Marina, additional, Minguillon, Carolina, additional, Fauria, Karine, additional, Holst, Sebastian C, additional, Garces, Pilar, additional, Arqueros, Aurora, additional, Iranzo, Álex, additional, Suarez‐Calvet, Marc, additional, Mueggler, Thomas, additional, Gispert, Juan Domingo, additional, Molinuevo, Jose Luis, additional, and Grau‐Rivera, Oriol, additional

Published
2023
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18. Plasma biomarkers rates of change across the preclinical stage of Alzheimer’s disease: a longitudinal study

Author

González Escalante, Armand, primary, Milà‐Alomà, Marta, additional, Ashton, Nicholas J., additional, Shekari, Mahnaz, additional, Salvadó, Gemma, additional, Ortiz‐Romero, Paula, additional, Montoliu‐Gaya, Laia, additional, Benedet, Andrea Lessa, additional, Karikari, Thomas K, additional, Rodriguez, Juan Lantero, additional, Vanmechelen, Eugeen, additional, Sánchez‐Benavides, Gonzalo, additional, Minguillon, Carolina, additional, Fauria, Karine, additional, Molinuevo, Jose Luis, additional, Zetterberg, Henrik, additional, del Campo, Marta, additional, Gispert, Juan Domingo, additional, Blennow, Kaj, additional, Vilor‐Tejedor, Natalia, additional, and Suarez‐Calvet, Marc, additional

Published
2023
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19. CSF sTREM2 and YKL‐40 modify the balance between soluble and fibrillary β‐amyloid in non‐demented individuals

Author

Cacciaglia, Raffaele, primary, Falcon, Carles, additional, Shekari, Mahnaz, additional, Salvadó, Gemma, additional, Milà‐Alomà, Marta, additional, Kollmorgen, Gwendlyn, additional, Carboni, Margherita, additional, Molinuevo, Jose Luis, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Suarez‐Calvet, Marc, additional, and Gispert, Juan Domingo, additional

Published
2023
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20. AMYPAD: Correlation of Amyloid PET results with anxiety and depressive symptoms in SCD+, MCI and dementia patients

Author

Zeyen, Philip, primary, Sannemann, Lena, additional, Escher, Claus, additional, Maier, Franziska, additional, Rostamzadeh, Ayda, additional, Drzezga, Alexander, additional, Giehl, Kathrin, additional, Bischof, Gerard N, additional, Hönig, Merle C., additional, Altomare, Daniele, additional, Garibotto, Valentina, additional, Barkhof, Frederik, additional, Scheltens, Philip, additional, van Berckel, Bart N.M., additional, Collij, Lyduine E., additional, Molinuevo, Jose Luis, additional, Grau‐Rivera, Oriol, additional, Gispert, Juan Domingo, additional, Delrieu, Julien, additional, Payoux, Pierre, additional, Nordberg, Agneta K, additional, Savitcheva, Irina, additional, Walker, Zuzana, additional, Edison, Paul, additional, Demonet, Jean‐François, additional, Stephens, Andrew W., additional, Gismondi, Rossella, additional, Farrar, Gill, additional, Frisoni, Giovanni B, additional, and Jessen, Frank, additional

Published
2023
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21. Sex‐dependent effects on the association between air pollution and longitudinal changes in CSF and plasma biomarkers of Alzheimer’s disease

Author

Vilor‐Tejedor, Natalia, primary, Escalante, Armand González, additional, Rodríguez‐Fernández, Blanca, additional, Genius, Patricia, additional, Milà‐Alomà, Marta, additional, Ortiz‐Romero, Paula, additional, Cirach, Marta, additional, Nieuwenhuijsen, Mark, additional, Sunyer, Jordi, additional, Minguillon, Carolina, additional, Fauria, Karine, additional, Kollmorgen, Gwendlyn, additional, Carboni, Margherita, additional, Molinuevo, Jose Luis, additional, Navarro, Arcadi, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Suarez‐Calvet, Marc, additional, and Gispert, Juan Domingo, additional

Published
2023
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22. Brain‐age prediction and its associations with glial and synaptic CSF markers

Author

Cumplido‐Mayoral, Irene, primary, Milà‐Alomà, Marta, additional, Falcon, Carles, additional, Cacciaglia, Raffaele, additional, Minguillon, Carolina, additional, Fauria, Karine, additional, Molinuevo, Jose Luis, additional, Kollmorgen, Gwendlyn, additional, Suridjan, Ivonne, additional, Wild, Norbert, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Suarez‐Calvet, Marc, additional, Vilaplana, Verónica, additional, and Gispert, Juan Domingo, additional

Published
2023
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23. Prevention of cognitive decline in subjective cognitive decline APOE‐ε4 carriers after Epigallocatechin gallate and a multimodal intervention, the PENSA study: 1‐year follow‐up results of the randomized controlled trial

Author

Forcano, Laura, primary, Boronat, Anna, additional, Lorenzo, Thais, additional, Cuenca, Aida, additional, Soldevila‐Domenech, Natalia, additional, Pizarro, Nieves, additional, Puig‐Pijoan, Albert, additional, Piera, Iris, additional, Gomis, Maria, additional, Diaz‐Pellicer, Patricia, additional, Torre, Rafael, additional, Grau‐Rivera, Oriol, additional, Sánchez‐Benavides, Gonzalo, additional, Fauria, Karine, additional, Minguillón, Carolina, additional, Molinuevo, Jose Luis, additional, and Gispert, Juan Domingo, additional

Published
2023
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24. Poor objective sleep quality is associated with worse cognition cross‐sectionally and longitudinally in cognitively unimpaired adults

Author

Stankeviciute, Laura, primary, Tort‐Colet, Núria, additional, Fernández‐Arcos, Ana, additional, López‐Martos, David, additional, Sánchez‐Benavides, Gonzalo, additional, Minguillon, Carolina, additional, Fauria, Karine, additional, Holst, Sebastian C, additional, Garces, Pilar, additional, Mueggler, Thomas, additional, Arqueros, Aurora, additional, Iranzo, Álex, additional, Suarez‐Calvet, Marc, additional, Gispert, Juan Domingo, additional, Molinuevo, Jose Luis, additional, and Grau‐Rivera, Oriol, additional

Published
2023
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25. CSF Aβ42/40 is associated with neurodegeneration independently of CSF p‐tau in the earliest AD continuum

Author

Cacciaglia, Raffaele, primary, Falcon, Carles, additional, Shekari, Mahnaz, additional, Salvadó, Gemma, additional, Milà‐Alomà, Marta, additional, Huguet, Jordi, additional, Garcia, Marina, additional, Kollmorgen, Gwendlyn, additional, Carboni, Margherita, additional, Molinuevo, Jose Luis, additional, Zetterberg, Henrik, additional, Blennow, Kaj, additional, Suarez‐Calvet, Marc, additional, and Gispert, Juan Domingo, additional

Published
2023
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27. Shared Latent Structures Between Imaging Features and Biomarkers in Early Stages of Alzheimer’s Disease

Author

Casamitjana, Adrià, Vilaplana, Verónica, Petrone, Paula, Molinuevo, José Luis, Gispert, Juan Domingo, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Rekik, Islem, editor, Unal, Gozde, editor, Adeli, Ehsan, editor, and Park, Sang Hyun, editor

Published
2018
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28. Inflammatory biomarkers in Alzheimer's disease plasma

Author

Bullmore, Edward T., Bhatti, Junaid, Chamberlain, Samuel J., Correia, Marta M., Crofts, Anna L., Dickinson, Amber, Foster, Andrew C., Kitzbichler, Manfred G., Knight, Clare, Lynall, Mary-Ellen, Maurice, Christina, O'Donnell, Ciara, Pointon, Linda J., St George Hyslop, Peter, Turner, Lorinda, Vertes, Petra, Widmer, Barry, Williams, Guy B., Morgan, B. Paul, Leckey, Claire A., Morgan, Angharad R., O'Hagan, Caroline, Touchard, Samuel, Cavanagh, Jonathan, Deith, Catherine, Farmer, Scott, McClean, John, McColl, Alison, McPherson, Andrew, Scouller, Paul, Sutherland, Murray, Boddeke, H.W.G.M., Richardson, Jill C., Khan, Shahid, Murphy, Phil, Parker, Christine A., Patel, Jai, Jones, Declan, de Boer, Peter, Kemp, John, Drevets, Wayne C., Nye, Jeffrey S., Wittenberg, Gayle, Isaac, John, Bhattacharya, Anindya, Carruthers, Nick, Kolb, Hartmuth, Pariante, Carmine M., Turkheimer, Federico, Barker, Gareth J., Byrom, Heidi, Cash, Diana, Cattaneo, Annamaria, Gee, Antony, Hastings, Caitlin, Mariani, Nicole, McLaughlin, Anna, Mondelli, Valeria, Nettis, Maria, Nikkheslat, Naghmeh, Randall, Karen, Sheridan, Hannah, Simmons, Camilla, Singh, Nisha, Van Loo, Victoria, Vicente-Rodriguez, Marta, Wood, Tobias C., Worrell, Courtney, Zajkowska, Zuzanna, Plath, Niels, Egebjerg, Jan, Eriksson, Hans, Gastambide, Francois, Adams, Karen Husted, Jeggo, Ross, Thomsen, Christian, Pederson, Jan Torleif, Campbell, Brian, Möller, Thomas, Nelson, Bob, Zorn, Stevin, O'Connor, Jason, Attenburrow, Mary Jane, Baird, Alison, Benjamin, Jithen, Clare, Stuart, Cowen, Philip, Huang, I-Shu (Dante), Hurley, Samuel, Jones, Helen, Lovestone, Simon, Mada, Francisca, Nevado-Holgado, Alejo, Oladejo, Akintayo, Ribe, Elena, Smith, Katy, Vyas, Anviti, Hughes, Zoe, Balice-Gordon, Rita, Duerr, James, Piro, Justin R., Sporn, Jonathan, Perry, V. Hugh, Cleal, Madeleine, Fryatt, Gemma, Gomez-Nicola, Diego, Mancuso, Renzo, Reynolds, Richard, Harrison, Neil A., Cercignani, Mara, Clarke, Charlotte L., Hoskins, Elizabeth, Kohn, Charmaine, Murray, Rosemary, Wilcock, Lauren, Wlazly, Dominika, Mount, Howard, Leckey, Claire, Nevado-Holgado, Alejo J., Barkhof, Frederik, Bertram, Lars, Blin, Olivier, Bos, Isabelle, Dobricic, Valerija, Engelborghs, Sebastiaan, Frisoni, Giovanni, Frölich, Lutz, Gabel, Silvey, Johannsen, Peter, Kettunen, Petronella, Kłoszewska, Iwona, Legido-Quigley, Cristina, Lleó, Alberto, Martinez-Lage, Pablo, Mecocci, Patrizia, Meersmans, Karen, Molinuevo, José Luis, Peyratout, Gwendoline, Popp, Julius, Richardson, Jill, Sala, Isabel, Scheltens, Philip, Streffer, Johannes, Soininen, Hikka, Tainta-Cuezva, Mikel, Teunissen, Charlotte, Tsolaki, Magda, Vandenberghe, Rik, Visser, Pieter Jelle, Vos, Stephanie, Wahlund, Lars-Olof, Wallin, Anders, Westwood, Sarah, and Zetterberg, Henrik

Published
2019
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29. Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study

Author

Lleó, Alberto, Alcolea, Daniel, Martínez-Lage, Pablo, Scheltens, Philip, Parnetti, Lucilla, Poirier, Judes, Simonsen, Anja H., Verbeek, Marcel M., Rosa-Neto, Pedro, Slot, Rosalinde E.R., Tainta, Mikel, Izaguirre, Andrea, Reijs, Babette L.R., Farotti, Lucia, Tsolaki, Magda, Vandenbergue, Rik, Freund-Levi, Yvonne, Verhey, Frans R.J., Clarimón, Jordi, Fortea, Juan, Frolich, Lutz, Santana, Isabel, Molinuevo, José Luis, Lehmann, Sylvain, Visser, Pieter J., Teunissen, Charlotte E., Zetterberg, Henrik, and Blennow, Kaj

Published
2019
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30. Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia

Author

Boada, Mercè, de Deyn, Peter Paul, Jones, Roy, Frisoni, Giovanni, Spiru, Luiza, Nobili, Flavio, Freund-Levi, Yvonne, Soininen, Hilkka, Verhey, Frans, Wallin, Åsa K., Touchon, Jacques, Rikkert, Marcel Olde, Rigaud, Anne-Sophie, Bullock, Roger, Tsolaki, Magda, Vellas, Bruno, Wilcock, Gordon, Hampel, Harald, Froelich, Lutz, Bakardjian, Hovagim, Benali, Habib, Bertin, Hugo, Bonheur, Joel, Boukadida, Laurie, Boukerrou, Nadia, Cavedo, Enrica, Chiesa, Patrizia, Colliot, Olivier, Dubois, Bruno, Dubois, Marion, Epelbaum, Stéphane, Gagliardi, Geoffroy, Genthon, Remy, Habert, Marie-Odile, Houot, Marion, Kas, Aurélie, Lamari, Foudil, Levy, Marcel, Lista, Simone, Metzinger, Christiane, Mochel, Fanny, Nyasse, Francis, Poisson, Catherine, Potier, Marie-Claude, Revillon, Marie, Santos, Antonio, Andrade, Katia Santos, Sole, Marine, Surtee, Mohmed, Thiebaud de Schotten, Michel, Vergallo, Andrea, Younsi, Nadjia, Slot, Rosalinde E.R., Sikkes, Sietske A.M., Berkhof, Johannes, Brodaty, Henry, Buckley, Rachel, Dardiotis, Efthimios, Guillo-Benarous, Francoise, Kochan, Nicole A., Luck, Tobias, Maruff, Paul, Molinuevo, José Luis, Kornhuber, Johannes, Reisberg, Barry, Riedel-Heller, Steffi G., Risacher, Shannon L., Roehr, Susanne, Sachdev, Perminder S., Scarmeas, Nikolaos, Scheltens, Philip, Shulman, Melanie B., Saykin, Andrew J., Verfaillie, Sander C.J., Visser, Pieter Jelle, Vos, Stephanie J.B., Wagner, Michael, Wolfsgruber, Steffen, Jessen, Frank, and van der Flier, Wiesje M.

Published
2019
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31. AMYPAD Diagnostic and Patient Management Study: Rationale and design

Author

Frisoni, Giovanni B., Barkhof, Frederik, Altomare, Daniele, Berkhof, Johannes, Boccardi, Marina, Canzoneri, Elisa, Collij, Lyduine, Drzezga, Alexander, Farrar, Gill, Garibotto, Valentina, Gismondi, Rossella, Gispert, Juan-Domingo, Jessen, Frank, Kivipelto, Miia, Lopes Alves, Isadora, Molinuevo, José Luis, Nordberg, Agneta, Payoux, Pierre, Ritchie, Craig, Savicheva, Irina, Scheltens, Philip, Schmidt, Mark E., Schott, Jonathan M., Stephens, Andrew, van Berckel, Bart, Vellas, Bruno, Walker, Zuzana, and Raffa, Nicola

Published
2019
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32. Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease—Data from three memory clinic studies

Author

Hu, Xiaochen, Teunissen, Charlotte E., Spottke, Annika, Heneka, Michael T., Düzel, Emrah, Peters, Oliver, Li, Siyao, Priller, Josef, Buerger, Katharina, Teipel, Stefan, Laske, Christoph, Verfaillie, Sander C.J., Barkhof, Frederik, Coll-Padrós, Nina, Rami, Lorena, Molinuevo, Jose Luis, van der Flier, Wiesje M., and Jessen, Frank

Published
2019
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36. Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease

Author

Mattsson, Niklas, Groot, Colin, Jansen, Willemijn J., Landau, Susan M., Villemagne, Victor L., Engelborghs, Sebastiaan, Mintun, Mark M., Lleo, Alberto, Molinuevo, José Luis, Jagust, William J., Frisoni, Giovanni B., Ivanoiu, Adrian, Chételat, Gaël, Resende de Oliveira, Catarina, Rodrigue, Karen M., Kornhuber, Johannes, Wallin, Anders, Klimkowicz-Mrowiec, Aleksandra, Kandimalla, Ramesh, Popp, Julius, Aalten, Pauline P., Aarsland, Dag, Alcolea, Daniel, Almdahl, Ina S., Baldeiras, Inês, van Buchem, Mark A., Cavedo, Enrica, Chen, Kewei, Cohen, Ann D., Förster, Stefan, Fortea, Juan, Frederiksen, Kristian S., Freund-Levi, Yvonne, Gill, Kiran Dip, Gkatzima, Olymbia, Grimmer, Timo, Hampel, Harald, Herukka, Sanna-Kaisa, Johannsen, Peter, van Laere, Koen, de Leon, Mony J., Maier, Wolfgang, Marcusson, Jan, Meulenbroek, Olga, Møllergård, Hanne M., Morris, John C., Mroczko, Barbara, Nordlund, Arto, Prabhakar, Sudesh, Peters, Oliver, Rami, Lorena, Rodríguez-Rodríguez, Eloy, Roe, Catherine M., Rüther, Eckart, Santana, Isabel, Schröder, Johannes, Seo, Sang W., Soininen, Hilkka, Spiru, Luiza, Stomrud, Erik, Struyfs, Hanne, Teunissen, Charlotte E., Verhey, Frans R.J., Vos, Stephanie J.B., van Waalwijk van Doorn, Linda J.C., Waldemar, Gunhild, Wallin, Åsa K., Wiltfang, Jens, Vandenberghe, Rik, Brooks, David J., Fladby, Tormod, Rowe, Christopher C., Drzezga, Alexander, Verbeek, Marcel M., Sarazin, Marie, Wolk, David A., Fleisher, Adam S., Klunk, William E., Na, Duk L., Sánchez-Juan, Pascual, Lee, Dong Young, Nordberg, Agneta, Tsolaki, Magda, Camus, Vincent, Rinne, Juha O., Fagan, Anne M., Zetterberg, Henrik, Blennow, Kaj, Rabinovici, Gil D., Hansson, Oskar, van Berckel, Bart N.M., van der Flier, Wiesje M., Scheltens, Philip, Visser, Pieter Jelle, and Ossenkoppele, Rik

Published
2018
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38. NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

Author

Elliott, Cerise, Masliah, Eliezer, Ryan, Laurie, Silverberg, Nina, Jack, Clifford R., Jr., Bennett, David A., Blennow, Kaj, Carrillo, Maria C., Dunn, Billy, Haeberlein, Samantha Budd, Holtzman, David M., Jagust, William, Jessen, Frank, Karlawish, Jason, Liu, Enchi, Molinuevo, Jose Luis, Montine, Thomas, Phelps, Creighton, Rankin, Katherine P., Rowe, Christopher C., Scheltens, Philip, Siemers, Eric, Snyder, Heather M., and Sperling, Reisa

Published
2018
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40. The SCD-Well randomized controlled trial: Effects of a mindfulness-based intervention versus health education on mental health in patients with subjective cognitive decline (SCD)

Author

Ashton, Nicholas, Allais, Florence, Asselineau, Julien, Bachelet, Romain, Belleoud, Viviane, Benson, Clara, Bosch, Beatriz, Botton, Maelle, Casanova, Maria Pilar, Chocat, Anne, Delphin, Floriane, Demnitz-King, Harriet, Egret, Stéphanie, Gonneaud, Julie, Hye, Abdul, Philippe, Agathe Joret, La Joie, Renaud, Leon, Maria, Meiberth, Dix, Milz, Ester, Mueller, Hendrik, Mueller, Theresa, Ourry, Valentin, Ramirez, Alfredo, Rauchs, Géraldine, Reyrolle, Leslie, Richert, Laura, Salinero, Ana, Salmon, Eric, Sannemann, Lena, Satgunasingam, Yamna, Schlosser, Marco, Schwimmer, Christine, Steinhauser, Hilde, Tomadesso, Clémence, Vivien, Denis, Vuilleumier, Patrik, Wallet, Cédrick, Whitfield, Tim, Wingrove, Janet, Marchant, Natalie L., Barnhofer, Thorsten, Klimecki, Olga M., Poisnel, Géraldine, Lutz, Antoine, Arenaza-Urquijo, Eider, Collette, Fabienne, Wirth, Miranka, Schild, Ann-Katrin, Coll-Padrós, Nina, Horney, Deborah, Krolak-Salmon, Pierre, Molinuevo, José Luis, Walker, Zuzana, Maillard, Aline, Frison, Eric, Jessen, Frank, and Chételat, Gael

Published
2018
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42. Computer-assisted prediction of clinical progression in the earliest stages of AD

Author

Rhodius-Meester, Hanneke F.M., Liedes, Hilkka, Koikkalainen, Juha, Wolfsgruber, Steffen, Coll-Padros, Nina, Kornhuber, Johannes, Peters, Oliver, Jessen, Frank, Kleineidam, Luca, Molinuevo, José Luis, Rami, Lorena, Teunissen, Charlotte E., Barkhof, Frederik, Sikkes, Sietske A.M., Wesselman, Linda M.P., Slot, Rosalinde E.R., Verfaillie, Sander C.J., Scheltens, Philip, Tijms, Betty M., Lötjönen, Jyrki, and van der Flier, Wiesje M.

Published
2018
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43. Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer's disease

Author

Carmona-Iragui, María, Balasa, Mircea, Benejam, Bessy, Alcolea, Daniel, Fernández, Susana, Videla, Laura, Sala, Isabel, Sánchez-Saudinós, María Belén, Morenas-Rodriguez, Estrella, Ribosa-Nogué, Roser, Illán-Gala, Ignacio, Gonzalez-Ortiz, Sofía, Clarimón, Jordi, Schmitt, Frederick, Powell, David K., Bosch, Beatriz, Lladó, Albert, Rafii, Michael S., Head, Elizabeth, Molinuevo, José Luis, Blesa, Rafael, Videla, Sebastián, Lleó, Alberto, Sánchez-Valle, Raquel, and Fortea, Juan

Published
2017
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44. The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: A European Alzheimer's Disease Consortium study

Author

Bosco, Paolo, Redolfi, Alberto, Bocchetta, Martina, Ferrari, Clarissa, Mega, Anna, Galluzzi, Samantha, Austin, Mark, Chincarini, Andrea, Collins, D. Louis, Duchesne, Simon, Maréchal, Bénédicte, Roche, Alexis, Sensi, Francesco, Wolz, Robin, Alegret, Montserrat, Assal, Frederic, Balasa, Mircea, Bastin, Christine, Bougea, Anastasia, Emek-Savaş, Derya Durusu, Engelborghs, Sebastiaan, Grimmer, Timo, Grosu, Galina, Kramberger, Milica G., Lawlor, Brian, Mandic Stojmenovic, Gorana, Marinescu, Mihaela, Mecocci, Patrizia, Molinuevo, José Luis, Morais, Ricardo, Niemantsverdriet, Ellis, Nobili, Flavio, Ntovas, Konstantinos, O'Dwyer, Sarah, Paraskevas, George P., Pelini, Luca, Picco, Agnese, Salmon, Eric, Santana, Isabel, Sotolongo-Grau, Oscar, Spiru, Luiza, Stefanova, Elka, Popovic, Katarina Surlan, Tsolaki, Magda, Yener, Görsev G., Zekry, Dina, and Frisoni, Giovanni B.

Published
2017
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45. Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI)

Author

Nathan, Pradeep J., Lim, Yen Ying, Abbott, Rosemary, Galluzzi, Samantha, Marizzoni, Moira, Babiloni, Claudio, Albani, Diego, Bartres-Faz, David, Didic, Mira, Farotti, Lucia, Parnetti, Lucilla, Salvadori, Nicola, Müller, Bernhard W., Forloni, Gianluigi, Girtler, Nicola, Hensch, Tilman, Jovicich, Jorge, Leeuwis, Annebet, Marra, Camillo, Molinuevo, José Luis, Nobili, Flavio, Pariente, Jeremie, Payoux, Pierre, Ranjeva, Jean-Philippe, Rolandi, Elena, Rossini, Paolo Maria, Schönknecht, Peter, Soricelli, Andrea, Tsolaki, Magda, Visser, Pieter Jelle, Wiltfang, Jens, Richardson, Jill C., Bordet, Régis, Blin, Olivier, and Frisoni, Giovanni B.

Published
2017
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46. Recommendations for cerebrospinal fluid Alzheimer's disease biomarkers in the diagnostic evaluation of mild cognitive impairment

Author

Herukka, Sanna-Kaisa, Simonsen, Anja Hviid, Andreasen, Niels, Baldeiras, Ines, Bjerke, Maria, Blennow, Kaj, Engelborghs, Sebastiaan, Frisoni, Giovanni B., Gabryelewicz, Tomasz, Galluzzi, Samantha, Handels, Ron, Kramberger, Milica G., Kulczyńska, Agnieszka, Molinuevo, Jose Luis, Mroczko, Barbara, Nordberg, Agneta, Oliveira, Catarina Resende, Otto, Markus, Rinne, Juha O., Rot, Uroš, Saka, Esen, Soininen, Hilkka, Struyfs, Hanne, Suardi, Silvia, Visser, Pieter Jelle, Winblad, Bengt, Zetterberg, Henrik, and Waldemar, Gunhild

Published
2017
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47. Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia

Author

Simonsen, Anja Hviid, Herukka, Sanna-Kaisa, Andreasen, Niels, Baldeiras, Ines, Bjerke, Maria, Blennow, Kaj, Engelborghs, Sebastiaan, Frisoni, Giovanni B., Gabryelewicz, Tomasz, Galluzzi, Samantha, Handels, Ron, Kramberger, Milica G., Kulczyńska, Agnieszka, Molinuevo, Jose Luis, Mroczko, Barbara, Nordberg, Agneta, Oliveira, Catarina Resende, Otto, Markus, Rinne, Juha O., Rot, Uroš, Saka, Esen, Soininen, Hilkka, Struyfs, Hanne, Suardi, Silvia, Visser, Pieter Jelle, Winblad, Bengt, Zetterberg, Henrik, and Waldemar, Gunhild

Published
2017
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48. Consensus guidelines for lumbar puncture in patients with neurological diseases

Author

Engelborghs, Sebastiaan, Niemantsverdriet, Ellis, Struyfs, Hanne, Blennow, Kaj, Brouns, Raf, Comabella, Manuel, Dujmovic, Irena, van der Flier, Wiesje, Frölich, Lutz, Galimberti, Daniela, Gnanapavan, Sharmilee, Hemmer, Bernhard, Hoff, Erik, Hort, Jakub, Iacobaeus, Ellen, Ingelsson, Martin, Jan de Jong, Frank, Jonsson, Michael, Khalil, Michael, Kuhle, Jens, Lleó, Alberto, de Mendonça, Alexandre, Molinuevo, José Luis, Nagels, Guy, Paquet, Claire, Parnetti, Lucilla, Roks, Gerwin, Rosa-Neto, Pedro, Scheltens, Philip, Skårsgard, Constance, Stomrud, Erik, Tumani, Hayrettin, Visser, Pieter Jelle, Wallin, Anders, Winblad, Bengt, Zetterberg, Henrik, Duits, Flora, and Teunissen, Charlotte E.

Published
2017
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50. Astrocyte biomarkers GFAP and YKL‐40 mediate early Alzheimer's disease progression.

Author

Pelkmans, Wiesje, Shekari, Mahnaz, Brugulat‐Serrat, Anna, Sánchez‐Benavides, Gonzalo, Minguillón, Carolina, Fauria, Karine, Molinuevo, Jose Luis, Grau‐Rivera, Oriol, González Escalante, Armand, Kollmorgen, Gwendlyn, Carboni, Margherita, Ashton, Nicholas J., Zetterberg, Henrik, Blennow, Kaj, Suarez‐Calvet, Marc, and Gispert, Juan Domingo

Abstract

INTRODUCTION: We studied how biomarkers of reactive astrogliosis mediate the pathogenic cascade in the earliest Alzheimer's disease (AD) stages. METHODS: We performed path analysis on data from 384 cognitively unimpaired individuals from the ALzheimer and FAmilies (ALFA)+ study using structural equation modeling to quantify the relationships between biomarkers of reactive astrogliosis and the AD pathological cascade. RESULTS: Cerebrospinal fluid (CSF) amyloid beta (Aβ)42/40 was associated with Aβ aggregation on positron emission tomography (PET) and with CSF p‐tau181, which was in turn directly associated with CSF neurofilament light (NfL). Plasma glial fibrillary acidic protein (GFAP) mediated the relationship between CSF Aβ42/40 and Aβ‐PET, and CSF YKL‐40 partly explained the association between Aβ‐PET, p‐tau181, and NfL. DISCUSSION: Our results suggest that reactive astrogliosis, as indicated by different fluid biomarkers, influences the pathogenic cascade during the preclinical stage of AD. While plasma GFAP mediates the early association between soluble and insoluble Aβ, CSF YKL‐40 mediates the latter association between Aβ and downstream Aβ‐induced tau pathology and tau‐induced neuronal injury. Highlights: Lower CSF Aβ42/40 was directly linked to higher plasma GFAP concentrations.Plasma GFAP partially explained the relationship between soluble Aβ and insoluble Aβ.CSF YKL‐40 mediated Aβ‐induced tau phosphorylation and tau‐induced neuronal injury. [ABSTRACT FROM AUTHOR]

Published
2024
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