25 results on '"Molinero, J. P."'
Search Results
2. Lack of clinical evidence on low-level laser therapy (LLLT) on dental titanium implant: a systematic review
- Author
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Prados-Frutos, J. C., Rodríguez-Molinero, J., Prados-Privado, M., Torres, J. H., and Rojo, R.
- Published
- 2016
- Full Text
- View/download PDF
3. Mediterranean marine copepods: basin-scale trends of the calanoid Centropages typicus
- Author
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Molinero, J. C., Vukanič, V., Lučić, D., Ibanez, F., Nival, P., Licandro, P., Calbet, A., Christou, E. D., Daly-Yahia, N., Fernandez de Puelles, M. L., Mazzocchi, M. G., and Siokou-Frangou, I.
- Published
- 2009
- Full Text
- View/download PDF
4. Predictive Modeling of a Simple Field Matrix Diffusion Experiment Addressing Radionuclide Transport in Fractured Rock. Is It So Straightforward?
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Soler, J. M., Neretnieks, I., Moreno, L., Liu, L., Meng, S., Svensson, U., Iraola, A., Ebrahimi, H., Trinchero, P., Molinero, J., Vidstrand, P., Deissmann, G., Říha, J., Hokr, M., Vetešník, A., Vopálka, D., Gvoždík, L., Polák, M., Trpkošová, D., and Havlová, V.
- Abstract
The SKB GroundWater Flow and Transport of Solutes Task Force is an international forum in the area of conceptual and numerical modeling of groundwater flow and solute transport in fractured rocks relevant for the deep geological disposal of radioactive waste. Two in situ matrix diffusion experiments in crystalline rock (gneiss) were performed at POSIVA's ONKALO underground facility in Finland. Synthetic groundwater containing several conservative and sorbing radiotracers was injected at one end of a borehole interval and flowed along a thin annulus toward the opposite end. Several teams performed predictive modeling of the tracer breakthrough curves using "conventional" modeling approaches (constant diffusion and sorption in the rock, no or minimum rock heterogeneity). Supporting information, derived from small-scale laboratory experiments, was provided. The teams were free to implement different concepts, use different codes, and apply the transport and retention parameters that they considered to be most suited (i.e., not a benchmark exercise). The main goal was the comparison of the different sets of results and the analysis of the possible differences for this relatively simple experimental setup with a well-defined geometry. Even though the experiment was designed to study matrix diffusion, the calculated peaks of the breakthrough curves were very sensitive to the assumed magnitude of dispersion in the borehole annulus. However, given the very different timescales for advection and matrix diffusion, the tails of the curves provided information concerning diffusion and retention in the rock matrix regardless of the magnitude of dispersion. In addition, although the task was designed to be a blind modeling exercise, the model results have also been compared to the measured experimental breakthroughs. Experimental results tend to show relatively small activities, wide breakthroughs, and early first arrivals, which are somewhat similar to model results using large dispersivity values. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
5. Differences in water depth determine leaf-litter decomposition in streams: implications on impact assessment reliability
- Author
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Martínez A., Basaguren A., Larrañaga A., Molinero J., Pérez J., Sagarduy M., and Pozo J.
- Subjects
leaf-litter decomposition ,water depth ,assessment ,Aquaculture. Fisheries. Angling ,SH1-691 - Abstract
Leaf-litter decomposition is a widespread functional indicator to assess the stream ecosystem status. However, the spatial location of leaf-bags could distort the impact assessment since intrinsic features of a given site have an important role in the spatial distribution of macroinvertebrates, which could affect decomposition rate. A source of variability that can be easily controlled is the water depth at which bags are incubated in stream bed. Therefore, we tested if water depth within a same mesohabitat (riffles) can determine decomposition rates. Due to the seasonal variability of macroinvertebrate assemblages in temperate regions, the study was performed in autumn-winter and spring to test the consistency of the findings. In three streams from North of Spain 15 mesh bags with alder leaves were placed in riffles covering a gradient of depths. Depth had a positive effect on decomposition rates and biomass of associated total invertebrates and shredders in autumn-winter, fauna variables helping to explain the differences in rates. In spring, depth affected negatively rates, the observed variability being weakly explained by invertebrates, which did not show differences along depth. Despite the opposite trend between seasons, water depth influences the decomposition rates, which may reduce or increase differences among systems if the water depth distribution is greatly biased. Our study highlights the importance of covering a similar range of water depths in the different systems being compared.
- Published
- 2016
- Full Text
- View/download PDF
6. Predictive Numerical Modeling of Artificial Tracers Migration in the Large-Scale Heating and Hydration Experiments of the FEBEX Project
- Author
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Samper, J., Delgado, J., Molinero, J., and Juncosa, R.
- Published
- 1997
- Full Text
- View/download PDF
7. Feeding mechanism and capture success of european whitefish (Coregonus lavaretus L.) larvae
- Author
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Mahjoub M.-S., Anneville O., Molinero J. C., Souissi S., and Hwang J.-S.
- Subjects
feeding mechanism ,capture success ,behavior ,fractal dimension ,Coregonuslavaretus larvae ,Aquaculture. Fisheries. Angling ,SH1-691 - Abstract
Feeding success is a key factor for larval growth and survival, and is highly dependent on small-scale processes which occur during the predator-prey interaction. We studied the feeding mechanisms involved in the capture success of the European whitefish (Coregonus lavaretus) larvae using video recordings. The successful predatory sequence of this species consists of the following 5 events: encounter, pursuit (including fixation), strike, capture and ingestion. C. lavaretus larvae can exhibit an “S” shaped posture and always strikes on its prey from beyond. The mean fixation distance for wild larvae was 1.75 ± 0.71 mm and for reared larvae was 1.65 ± 0.76 mm. This distance was significantly different between failed and successful snaps, and seemed to be an important parameter to the capture success of C. lavaretus larvae. The analysis of the complexity in predator’s swimming path showed that more convoluted approaches are less likely to lead to a fruitful attack.
- Published
- 2008
- Full Text
- View/download PDF
8. Migration Experiments in Compacted Ca-Bentonite
- Author
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García-Gutiérrez, M., Missana, T., Molinero, J., Yllera, A., and Mingarro, M.
- Published
- 1998
- Full Text
- View/download PDF
9. Afforestation with Eucalyptus globulus and leaf litter decomposition in streams of northern Spain
- Author
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Pozo, J., Basaguren, A., Elósegui, A., Molinero, J., Fabre, E., and Chauvet, E.
- Published
- 1998
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10. Synthesis and properties of Nα-lauroyl-L-arginine dipeptides from collagen-lauroyl-L-arginine dipeptides from collagen
- Author
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Molinero, J., Julia, M. R., Erra, P., Robert, M., and Infante, M. R.
- Published
- 1988
- Full Text
- View/download PDF
11. Lipopeptidic surfactants: I. Neutral N-lauroyl-I-arginine dipeptides from pure amino acids
- Author
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Infante, M. R., Molinero, J., Bosch, P., Juláa, M. R., and Erra, P.
- Published
- 1989
- Full Text
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12. Body size and mobility explain species centralities in the Gulf of California food web
- Author
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Olmo Gilabert, R., Navia, A. F., De La Cruz-Agüero, G., Molinero, J. C., Sommer, U., and Scotti, M.
- Abstract
AbstractAnthropic activities impact ecosystems worldwide thus contributing to the rapid erosion of biodiversity. The failure of traditional strategies targeting single species highlighted ecosystems as the most suitable scale to plan biodiversity management. Network analysis represents an ideal tool to model interactions in ecosystems and centrality indices have been extensively applied to quantify the structural and functional importance of species in food webs. However, many network studies fail in deciphering the ecological mechanisms that lead some species to occupy the most central positions in food webs. To address this question, we built a high-resolution food web of the Gulf of California and quantified species position using 15 centrality indices and the trophic level. We then modelled the values of each index as a function of traits and other attributes (e.g., habitat). We found that body size and mobility are the best predictors of indices that characterize species importance at local, meso- and global scale, especially in presence of data accounting for energy direction. This result extends previous findings that illustrated how a restricted set of traitaxes can predict whether two species interact in food webs. In particular, we show that traits can also help understanding the way species are affected by and mediate indirect effects. The traits allow focusing on the processes that shape the food web, rather than providing case-specific indications as the taxonomy-based approach. We suggest that future network studies should consider the traits to explicitly identify the causal relationships that link anthropic impacts to role changes of species in food webs.
- Published
- 2019
- Full Text
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13. Atrapamientos y choques extraarticulares de la cadera: revisión de la literatura
- Author
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Arévalo Galeano, N., Santamaría Guinea, N., Gredilla Molinero, J., and Grande Bárez, M.
- Abstract
El dolor inguinal o de cadera es un motivo de consulta muy frecuente. Debido a las múltiples causas que pueden generarlo, y a que en muchas ocasiones comparten características clínicas y demográficas, las pruebas de imagen desempeñan un papel complementario en el diagnóstico etiológico. Se han descrito nuevas formas de atrapamiento extraarticular de la cadera como causa de dolor y limitación funcional, en especial en pacientes jóvenes activos. Incluyen el atrapamiento isquiofemoral, el choque subespinoso o de la espina iliaca anteroinferior, el atrapamiento del iliopsoas y el choque pélvico-trocantéreo. De forma general, se deben a un problema mecánico que conduce al contacto anormal o excesivo entre el fémur proximal y la pelvis ósea, o las partes blandas interpuestas. Realizamos una revisión actualizada de estas formas de atrapamiento extraarticular de la cadera, describiendo la fisiopatología, las manifestaciones clínicas, los hallazgos radiológicos más comunes y el tratamiento.
- Published
- 2018
- Full Text
- View/download PDF
14. Descripción de un caso de Combined central and peripheral demyelinization
- Author
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Cuenca Hernández, R., Gordo Mañas, R., and Gredilla Molinero, J.
- Published
- 2017
- Full Text
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15. Simulating concrete degradation processes by reactive transport models
- Author
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Galíndez, J. M., Molinero, J., Samper, J., Yang, C. B., Galíndez, J. M., Molinero, J., Samper, J., and Yang, C. B.
- Abstract
Cement-based materials are commonly used in the multibarrier systems of radioactive waste repositories. Under the sub-surface environmental conditions they are exposed to during service-life, the chemical composition of the initially highly alkaline cement pore fluid may be altered by the influence of external ions and the leaching of dissolved species present in the cement interstitial solution, both of which processes are mainly ruled by ionic diffusion. Furthermore, the perturbation induced in the local thermodynamic equilibrium of the system yields to a series of dissolution/precipitation reactions which may result in a significant reorganization of the microstructure of concrete, in terms of both the distribution of mineral phases and the physical morphology of the capillary pore network, thus causing the concrete properties to undergo a gradual decline. Therefore, the long-term performance of concrete structures is a relevant issue in relation to the safety assessment of radioactive waste disposals. The analysis of the evolution of concrete degradation is a challenging task. It is also one that stresses the relevance of the development of reliable modeling techniques aimed at the prediction of long-term concrete behavior. The present work deals with the conceptualization of concrete both as a mineral aggregate, thus susceptible to deterioration, and as a porous material, where transport processes are expected to take place. Coupled reactive transport models are required to cope with the highly complex cyclic interactions arising between the chemical reactions which take place in the water-concrete interface and diffusive and advective transport in the aqueous phase. The approach taken herein aims at formulating and testing reactive transport numerical models by reproducing recent experiments reported in the scientific literature. Such procedure is intended to provide insight into the very nature of the phenomena involved, particularly those related to the appropriate methods available to describe ionic diffusion and the accuracy of the constitutive laws (e.g., porosity/permeability, porosity/diffusivity, etc.) developed for cement-based materials.
- Published
- 2006
- Full Text
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16. Actualización en el diagnóstico radiológico de la otosclerosis
- Author
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Gredilla Molinero, J., Mancheño Losa, M., Santamaría Guinea, N., Arévalo Galeano, N., and Grande Bárez, M.
- Abstract
La otosclerosis es una otodistrofia primaria del hueso temporal que produce una hipoacusia de transmisión progresiva. El diagnóstico es generalmente clínico, pero en ocasiones es necesaria la realización de una tomografía computarizada multidetector (TCMD), que es la técnica de imagen de elección. El objetivo de este artículo es realizar una actualización sistemática de la utilidad de las técnicas de imagen en el diagnóstico y la valoración posquirúrgica de la otosclerosis, fundamentalmente del papel de la TCMD, con el fin de disminuir el riesgo quirúrgico.
- Published
- 2016
- Full Text
- View/download PDF
17. Impact of timber harvesting on litterfall inputs and benthic coarse particulate organic matter (CPOM) storage in a small stream draining a eucalyptus plantation.
- Author
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Santiago, J., Molinero, J., and Pozo, J.
- Subjects
DISSOLVED organic matter ,LOGGING ,BENTHIC plants ,RIVERS ,DRAINAGE ,EUCALYPTUS ,TREE farms ,HARVESTING ,FOREST ecology - Abstract
Abstract: Eucalyptus plantations have a short rotation cycle and harvesting occurs every 12–15years, with the potential to modify the ecological integrity of the small streams draining the harvested areas through the reduction of litterfall inputs. We studied litterfall inputs and benthic coarse particulate organic matter (CPOM) storage in a small headwater stream draining a eucalyptus (Eucalyptus globulus Labill.) plantation before and after clear felling of the plantation. We hypothesized that wood harvesting will result in a reduction of CPOM inputs and storage in the stream. Litterfall inputs ranged 530–700gm
−2 y−1 and were approximately halved (200–320gm−2 y−1 ) after the harvesting of the eucalyptus trees. Bark and woody materials showed the largest reduction. Leaf inputs were initially reduced sharply, but, during the second year after the harvest, they recovered to about 90% of the values observed before the harvesting. Harvesting of the eucalyptus plantation caused an increase of benthic CPOM storage to 535gm−2 , but this was a temporary effect and these materials were washed downstream of the study reach. One year after the harvesting, benthic CPOM was reduced below 15gm−2 . Bark, twigs and other woody residues generated during the preparation of the logs for transportation were retained within the study site and represented the main component (>90%) of the benthic CPOM after timber harvesting. However, 2years after the harvesting, low inputs of these materials caused an overall reduction of in-stream retention and residence time of benthic CPOM. Amount and composition of benthic CPOM changed quickly in response to alterations of the riparian forest, so we propose the use of CPOM as an indicator of the impact of forestry activities on the ecological functioning of small streams. [Copyright &y& Elsevier]- Published
- 2011
- Full Text
- View/download PDF
18. Synergistic effects of fishing-induced demographic changes and climate variation on fish population dynamics.
- Author
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Hidalgo, M., Rouyer, T., Molinero, J. C., Massutí, E., Moranta, J., Guijarro, B., and Stenseth, N. Chr.
- Subjects
DEMOGRAPHIC change ,CLIMATE change ,FISHING ,FISH populations ,EUROPEAN hake ,DYNAMICS - Abstract
The article discusses a study on the synergistic impact of demographic changes and climate variation resulting from fishing on fish population dynamics. The study, involving the European hake (EH) or Merluccius merluccius found in the Balearic Sea in the Northwestern Mediterranean Sea, observes the periodicity changes of the variability of the catch per unit effort (CPUE) time series as well as the changes in the relationship of such variability with the environment. Results show that fishing has likely eroded the age structure of the fish population, leading to a more recruitment-dependent population that is more sensitive to climate changes. It adds that the study reflects the need to include the association between exploitation, climate and population in fishery management.
- Published
- 2011
- Full Text
- View/download PDF
19. Modelling the radionuclide transfer from bedrock to surface systems at Forsmark site (Sweden)
- Author
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Grandia, F., Sena, C., Arcos, D., Molinero, J., Duro, L., and Bruno, J.
- Abstract
Quaternary sediments and soils at the Forsmark site (Sweden) would constitute the last barrier for radionuclide migration interposed between a deep repository of high level nuclear wastes (HLNW) and surface ecological systems. The retention capacity of these sediments is evaluated by means of reactive transport simulations. Two different scenarios have been modelled: (1) Inflow of deep fluids carrying radionuclides into shallow aquifers hosted in the carbonate glacial till, and (2) Inflow of deep fluids carrying radionuclides into organic matter-bearing clays. The model results predict that caesium is very efficiently retained in both scenarios for periods longer than 3000 years due to the strong affinity of this ion with the frayed edgesites of the illite layers. Strontium is also retained via cation exchange in illite and, in a lesser extent, via co-precipitation in calcite. The retention efficiency for strontium, however, quickly decreases to 0 after 1000 years. Uranium is retained in both scenarios with retention efficiencies higher than 40% at long term (>3000 years) due to precipitation of amorphous uraninite and adsorption on Fe(III) oxyhydroxides. Radium is only retained in the till aquifer since co-precipitation with barium sulphate does not occur in the clay porewater.
- Published
- 2009
- Full Text
- View/download PDF
20. Simulating concrete degradation processes by reactive transport models
- Author
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Gal?ndez, J., Molinero, J., Samper, J., and Yang, C.
- Abstract
Cement-based materials are commonly used in the multibarrier systems of radioactive waste repositories. Under the sub-surface environmental conditions they are exposed to during service-life, the chemical composition of the initially highly alkaline cement pore fluid may be altered by the influence of external ions and the leaching of dissolved species present in the cement interstitial solution, both of which processes are mainly ruled by ionic diffusion. Furthermore, the perturbation induced in the local thermodynamic equilibrium of the system yields to a series of dissolution/precipitation reactions which may result in a significant reorganization of the microstructure of concrete, in terms of both the distribution of mineral phases and the physical morphology of the capillary pore network, thus causing the concrete properties to undergo a gradual decline. Therefore, the long-term performance of concrete structures is a relevant issue in relation to the safety assessment of radioactive waste disposals. The analysis of the evolution of concrete degradation is a challenging task. It is also one that stresses the relevance of the development of reliable modeling techniques aimed at the prediction of long-term concrete behavior. The present work deals with the conceptualization of concrete both as a mineral aggregate, thus susceptible to deterioration, and as a porous material, where transport processes are expected to take place. Coupled reactive transport models are required to cope with the highly complex cyclic interactions arising between the chemical reactions which take place in the water-concrete interface and diffusive and advective transport in the aqueous phase. The approach taken herein aims at formulating and testing reactive transport numerical models by reproducing recent experiments reported in the scientific literature. Such procedure is intended to provide insight into the very nature of the phenomena involved, particularly those related to the appropriate methods available to describe ionic diffusion and the accuracy of the constitutive laws (e.g.,?porosity/permeability, porosity/diffusivity, etc.) developed for cement-based materials.
- Published
- 2006
21. Organic matter, nitrogen and phosphorus fluxes associated with leaf litter in two small streams with different riparian vegetation: a budget approach
- Author
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Molinero, J. Pozo
- Abstract
We studied the leaf budget in two forest stream sites: site D was located in a stream that flows through deciduous forest, and site E was located in a stream that flows through a eucalyptus plantation. Leaf inputs, transport, benthic storage and breakdown rates at both sites at different periods were measured over 5 years. Data have been combined to calculate leaf budgets with the assumption that both streams were in steady state. The total leaf input was 20 % lower at site E, but the mean benthic stock of leaves and the amount of leaves that was processed were about 1.5 times higher than at site D. Inputs of nitrogen and phosphorus associated with leaves were 50 and 20 % lower at site E, but small differences in the benthic storage of nutrients were observed between the two sites. The streams processed 31-57 % of the nitrogen, and 20-57 % of the phosphorus contained in the leaf input. Afforestation with eucalyptus has a low impact on leaf litter processing as the longer residence time of eucalyptus leaves in the stream balances their lower processing rate. However, it modifies nutrient fluxes associated with leaf litter due to the low nutrient content of eucalyptus leaves and to their role as nutrient sources during leaf decay. At both streams, alder litter was processed more efficiently than other species and was the main source of nitrogen and phosphorus for stream decomposers. We hypothesize that dependence on this fast decaying species is an indication of the disturbance of CPOM dynamics due to historical changes in our streams and that it may be difficult to isolate the effects of former forest disturbances from the impact of eucalyptus plantations.
- Published
- 2006
- Full Text
- View/download PDF
22. Synthesis and properties of Nα-lauroyl-L-arginine dipeptides from collagen-lauroyl-L-arginine dipeptides from collagen
- Author
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Molinero, J., Julia, M., Erra, P., Robert, M., and Infante, M.
- Abstract
Abstract: In order to obtain protein-based amphoteric surfactants with antimicrobial properties, N
α -lauroyl arginine dipeptides have been prepared by condensation between Nα -lauroyl arginine and amino acids which come from a collagen hydrolysate. Some surfactant properties and the minimum inhibitory concentration against Gram positive and Gram negative bacteria have been evaluated. All types of compounds presented a surfactant-like behavior. Furthermore, the compounds described in this paper may be considered as mild preservative or protective substances.- Published
- 1988
- Full Text
- View/download PDF
23. Inputs of Particulate Organic Matter to Streams with Different Riparian Vegetation
- Author
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Pozo, J., González, E., Díez, J. R., Molinero, J., and Elósegui, A.
- Abstract
To test whether afforestation with eucalyptus affects the amount, quality, and timing of litter inputs, we evaluated the inputs of coarse particulate organic matter (CPOM) to 2 headwater streams, one flowing through a mixed deciduous forest and one through a plantation of Eucalyptus globulus. Vertical and lateral traps were sampled at least monthly, and the material collected was sorted into 4 main categories: fallen leaves (several species), fruits and flowers, twigs and bark, and debris. The eucalyptus plantation resulted in a reduction of 32% of total litter inputs, and 73% of lateral inputs, compared to the mixed deciduous forest. It also had a less marked seasonal pattern of inputs, and different timing of peak litterfall, the peak in the deciduous forest occurring in autumn, whereas in the eucalyptus plantation the peak occurred in summer. Similarly, leaf diversity was greatly reduced under the eucalyptus, with 98% of the leaf litter mass from 1 species, resulting in broad changes in litter quality. Litter inputs in the eucalyptus plantations contributed 67% less nitrogen and 65% less phosphorus to the stream than in the deciduous forest. Although eucalyptus plantations result in broad changes in organic inputs, no drastic impacts on the structure or function of benthic communities are evident so far in the Agüera stream. Nevertheless, caution suggests maintaining the quantity and timing of allochthonous inputs by keeping buffer strips of native riparian forest.
- Published
- 1997
- Full Text
- View/download PDF
24. ChemInform Abstract: Synthesis and Properties of Nα‐Lauroyl‐L‐arginine Dipeptides from Collagen.
- Author
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MOLINERO, J., JULIA, M. R., ERRA, P., ROBERT, M., and INFANTE, M. R.
- Published
- 1988
- Full Text
- View/download PDF
25. Clinical outcomes of PCI with rotational atherectomy: the European multicentre Euro4C registry
- Author
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Markus Meyer-Gessner, Wojciech Zajdel, Emanuele Barbato, Didier Carrié, Jorge Palazuelos Molinero, Krzysztof Reczuch, Sławomir Dobrzycki, Thibault Lhermusier, Miroslaw Ferenc, Erwan Bressollette, Guillaume Cayla, Frédéric Bouisset, Flavio Ribichini, Hôpital de Rangueil, CHU Toulouse [Toulouse], 'Federico II' University of Naples Medical School, University of Wrocław [Poland] (UWr), University of Bialystok, Augusta Krankenhaus, Nouvelles Cliniques Nantaises - NCN [Nantes], Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Hospital Central de la Defensa Gomez Ulla, University Heart Centre Freiburg - Bad Krozingen, University of Verona (UNIVR), Bouisset, F., Barbato, E., Reczuch, K., Dobrzycki, S., Meyer-Gessner, M., Bressollette, E., Cayla, G., Lhermusier, T., Zajdel, W., Molinero, J. P., Ferenc, M., Ribichini, F., and Carrie, D.
- Subjects
Atherectomy, Coronary ,Male ,Registrie ,Atherectomy ,MESH: Registries ,medicine.medical_treatment ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,MESH: Stroke Volume ,Ventricular Function, Left ,MESH: Aged, 80 and over ,0302 clinical medicine ,Retrospective Studie ,Undilatable lesion ,Prospective Studies ,Registries ,030212 general & internal medicine ,Myocardial infarction ,Stroke ,MESH: Atherectomy, Coronary / instrumentation ,MESH: Treatment Outcome ,Aged, 80 and over ,education.field_of_study ,Ejection fraction ,Calcified stenosi ,Multiple vessel disease ,3. Good health ,Europe ,Treatment Outcome ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,MESH: Percutaneous Coronary Intervention ,Rotablator ,Human ,MESH: Atherectomy, Coronary / methods ,medicine.medical_specialty ,Acute coronary syndrome ,MESH: Coronary Artery Disease / diagnosis ,Population ,MESH: Ventricular Function, Left / physiology ,03 medical and health sciences ,Percutaneous Coronary Intervention ,MESH: Coronary Artery Disease / surgery ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Internal medicine ,Left main ,medicine ,Humans ,education ,Retrospective Studies ,Aged ,Interventional cardiology ,business.industry ,Percutaneous coronary intervention ,Stroke Volume ,MESH: Retrospective Studies ,medicine.disease ,MESH: Prospective Studies ,Prospective Studie ,MESH: Europe ,business ,Mace - Abstract
International audience; Aims: Despite the use of rotational atherectomy (RA) in interventional cardiology for over three decades, data regarding factors affecting the clinical outcomes of the RA procedure remain scarce. The aim of the present study was to describe the contemporary use and outcomes of RA in Europe.Methods and results: We conducted, for the first time, a prospective international registry in 8 European countries and 19 centres and included patients treated by percutaneous coronary intervention with RA. Between October 2016 and July 2018, 966 patients with complete data were recruited. Mean age was 74.5 years, 72.4% were male and 43.4% had diabetes. Initial presentation was an acute coronary syndrome (ACS) for 25.1% of the patients. Clinical success was observed in 91.9% of the procedures. The rate of in-hospital major adverse cardiac events (MACE) - defined as cardiovascular death, myocardial infarction, target lesion revascularisation, stroke and coronary artery bypass grafting - was 4.7%. At one year, the rate of MACE was 13.2%. Factors independently associated with the occurrence of MACE at one year were female gender, renal failure, ACS at admission, depressed left ventricular ejection fraction (LVEF) and presence of a significant left main coronary artery (LMCA) lesion.Conclusions: Despite the high level of complexity of the studied population, RA turned out to be an effective procedure with a low rate of in-hospital complications and demonstrated good immediate and midterm results.
- Published
- 2020
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