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2. Omalizumab Effectiveness in Severe Allergic Asthma with Multiple Allergic Comorbidities: A Post-Hoc Analysis of the STELLAIR Study

Author

Just J, Thonnelier C, Bourgoin-Heck M, Mala L, Molimard M, and Humbert M

Subjects
ig-e, multiple allergic comorbidities, omalizumab, severe allergic asthma, Immunologic diseases. Allergy, RC581-607
Abstract

Jocelyne Just,1– 3 Celine Thonnelier,4 Melisande Bourgoin-Heck,5 Laurence Mala,4 Mathieu Molimard,6 Marc Humbert7– 9 On behalf of the STELLAIR Investigators1Groupe Hospitalier Trousseau-La Roche Guyon, Service d’Allergologie, Paris, France; 2Université Paris Sorbonne, Paris, France; 3UMR 1153 - Centre de Recherche en Épidémiologie et Statistiques (CRESS), Paris, France; 4Novartis Pharma, Rueil Malmaison, France; 5Hôpital Trousseau, Service d’Allergologie, Paris, France; 6CHU de Bordeaux, Service de Pharmacologie Médicale, Bordeaux, France; 7Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre, France; 8AP-HP, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin-Bicêtre, France; 9INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, FranceCorrespondence: Jocelyne JustService d’Allergologie, Groupe hospitalier Trousseau-La Roche Guyon, 26 Avenue du Dr. Arnold Netter, Paris, 75012, FranceTel +33 1 71 73 68 47Fax +33 1 44 73 53 15Email jocelyne.just@aphp.frBackground: Immunoglobulin (Ig) E-mediated pathophysiological mechanisms are common in allergic diseases including severe allergic asthma (SAA). The anti-IgE monoclonal antibody omalizumab may be particularly beneficial for patients with SAA and multiple allergic comorbidities (AC) including perennial/seasonal rhinitis, conjunctivitis, atopic dermatitis (AD), and food allergy.Methods: We conducted a post-hoc analysis of the patients from the STELLAIR study (n=872, 149 minors and 723 adults). The patients were classified based on the presence of multiple AC (≥ 3 AC or < 3 AC) or AD as assessed by questionnaire. Response to omalizumab was assessed after 4– 6 months (T4– 6) and after 12 months (T12). Asthma response at T4– 6 was based on global evaluation of treatment effectiveness, reduction of ≥ 40% in annual exacerbation rate, and a combination of both. Asthma response at T12 was based on change in yearly exacerbation and hospitalization rates. AC improvement at T12 was based on patient perception.Results: Patients with ≥ 3 AC demonstrated a higher combined response to omalizumab (74.7% vs 58.3%) at T4– 6 and had reduced yearly exacerbation and hospitalization rates (88.9% vs 77.4% and − 94.0% vs − 70.5%, respectively). Patients with ≥ 3 AC were more likely to show an improvement in their AC (85.3% vs 51.9%) at T12. Results were similar in minors and adults. The presence of AD was associated with greater omalizumab effectiveness at T4– 6 and a greater AC improvement at T12. Improvement of AD and food allergies at T12 were 73.2% and 38.7%, respectively, in the population overall.Conclusion: This post-hoc analysis of the STELLAIR study shows that omalizumab is beneficial for all SAA patients and especially for patients with multiple AC or AD. In patients with ≥ 3 AC, omalizumab also improved AC outcomes.Keywords: Ig-E, multiple allergic comorbidities, omalizumab, severe allergic asthma

Published
2021

11. Sex-related Differences, Mortality and FEV1 Decline Among COPD Patients: The French Palomb Cohort

Author

Jestin-Guyon, N., primary, Ouaalaya, E.H., additional, Bernady, A., additional, Berteaud, E., additional, Casteigt, J., additional, Falque, L., additional, Le Guillou, F., additional, Moinard, J., additional, Molimard, M., additional, Nguyen, L., additional, Nocent, C., additional, Ozier, A., additional, Staali, M., additional, and Raherison-Semjen, C., additional

Published
2023
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14. Déterminants de la mortalité selon le sexe chez les patients BPCO : données de la cohorte Palomb

Author

Jestin-Guyon, N., primary, Ouaalaya, E.H., additional, Bernady, A., additional, Berteaud, E., additional, Casteigt, J., additional, Falque, L., additional, Le Guillou, F., additional, Moinard, J., additional, Molimard, M., additional, Nguyen, L., additional, Nocent, C., additional, Ozier, A., additional, Staali, M., additional, and Raherison-Semjen, C., additional

Published
2023
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15. Caractéristiques des patients asthmatiques sévères : données de la cohorte Palomb

Author

Jestin-Guyon, N., primary, Ouaalaya, E.H., additional, Bernady, A., additional, Berteaud, E., additional, Didier, A., additional, Dupuy-Grasset, M., additional, Guilleminault, L., additional, Le Guillou, F., additional, Melloni, B., additional, Molimard, M., additional, Nguyen, L., additional, Nocent, C., additional, Ozier, A., additional, Portel, L., additional, Prud’homme, A., additional, and Raherison-Semjen, C., additional

Published
2023
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23. Is diet partly responsible for differences in COVID-19 death rates between and within countries?

Author

Bousquet J., Anto J. M., Iaccarino G., Czarlewski W., Haahtela T., Anto A., Akdis C. A., Blain H., Canonica G. W., Cardona V., Cruz A. A., Illario M., Ivancevich J. C., Jutel M., Klimek L., Kuna P., Laune D., Larenas-Linnemann D., Mullol J., Papadopoulos N. G., Pfaar O., Samolinski B., Valiulis A., Yorgancioglu A., Zuberbier T., Abdul Latiff A. H., Abdullah B., Aberer W., Abusada N., Adcock I., Afani A., Agache I., Aggelidis X., Agustin J., Akdis C., Akdis M., Al-Ahmad M., Al-Zahab Bassam A., Aldrey-Palacios O., Alvarez Cuesta E., Alzaabi A., Amad S., Ambrocio G., Annesi-Maesano I., Ansotegui I., Anto J., Arshad H., Artesani M. C., Asayag E., Avolio F., Azhari K., Baiardini I., Bajrovic N., Bakakos P., Bakeyala Mongono S., Balotro-Torres C., Barba S., Barbara C., Barbosa E., Barreto B., Bartra J., Bateman E. D., Battur L., Bedbrook A., Bedolla Barajas M., Beghe B., Bel E., Ben Kheder A., Benson M., Berghea C., Bergmann K. -C., Bernstein D., Bewick M., Bialek S., Bialoszewski A., Bieber T., Billo N., Bilo M. B., Bindslev-Jensen C., Bjermer L., Bochenska Marciniak M., Bond C., Boner A., Bonini M., Bonini S., Bosnic-Anticevich S., Bosse I., Botskariova S., Bouchard J., Boulet L. -P., Bourret R., Bousquet P., Braido F., Briggs A., Brightling C., Brozek J., Buhl R., Bumbacea R., Burguete Cabanas M. T., Bush A., Busse W. W., Buters J., Caballero-Fonseca F., Calderon M. A., Calvo M., Camargos P., Camuzat T., Cano A., Capriles-Hulett A., Caraballo L., Carlsen K. -H., Caro J., Carr W., Carreon-Asuncion F., Carriazo A. M., Casale T., Castor M. A., Castro E., Cecchi L., Cepeda Sarabia A., Chandrasekharan R., Chang Y. -S., Chato-Andeza V., Chatzi L., Chatzidaki C., Chavannes N. H., Chen Y., Cheng L., Chivato T., Chkhartishvili E., Christoff G., Chrystyn H., Chu D. K., Chua A., Chuchalin A., Chung K. F., Ciceran A., Cingi C., Ciprandi G., Cirule I., Coelho A. C., Constantinidis J., Correia De Sousa J., Costa E., Costa D., Costa Dominguez M. D. C., Coste A., Cox L., Cullen J., Custovic A., Cvetkovski B., D'Amato G., Da Silva J., Dahl R., Dahlen S. -E., Daniilidis V., Darjazini Nahhas L., Darsow U., De Blay F., De Guia E., De Los Santos C., De Manuel Keenoy E., De Vries G., Deleanu D., Demoly P., Denburg J., Devillier P., Didier A., Dimou M., Dinh-Xuan A. T., Djukanovic R., Dokic D., Dominguez Silva M. G., Douagui H., Douladiris N., Doulaptsi M., Dray G., Dubakiene R., Durham S., Dykewicz M., Ebo D., Edelbaher N., Eklund P., El-Gamal Y., El-Sayed Z. A., El-Sayed S. S., El-Seify M., Emuzyte R., Enecilla L., Espinoza H., Espinoza Contreras J. G., Farrell J., Fernandez L., Fink Wagner A., Fiocchi A., Fokkens W. J., Fontaine J. -F., Forastiere F., Fuentes Perez J. M., Gaerlan-Resureccion E., Gaga M., Galvez Romero J. L., Gamkrelidze A., Garcia A., Garcia Cobas C. Y., Garcia Cruz M. D. L. L. H., Gayraud J., Gemicioglu B., Genova S., Gereda J., Gerth Van Wijk R., Gomez M., Gonzalez Diaz S., Gotua M., Grigoreas C., Grisle I., Guidacci M., Guldemond N., Gutter Z., Guzman A., Halloum R., Hamelmann E., Hammadi S., Harvey R., Heinrich J., Hejjaoui A., Hellquist-Dahl B., Hernandez Velazquez L., Hew M., Hossny E., Howarth P., Hrubisko M., Huerta Villalobos Y. R., Humbert M., Hyland M., Ibrahim M., Ilyina N., Irani C., Ispayeva Z., Jares E., Jarvis D., Jassem E., Jenko K., Jimeneracruz Uscanga R. D., Johnston S., Joos G., Jost M., Julge K., Jung K. -S., Just J., Kaidashev I., Kalayci O., Kalyoncu F., Kapsali J., Kardas P., Karjalainen J., Kasala C. A., Katotomichelakis M., Kazi B., Keil T., Keith P., Khaitov M., Khaltaev N., Kim Y. -Y., Kleine-Tebbe J., Koffi N'Goran B., Kompoti E., Kopac P., Koppelman G., Koren Jeverica A., Kosnik M., Kostov K. V., Kowalski M. L., Kralimarkova T., Kramer Vrscaj K., Kraxner H., Kreft S., Kritikos V., Kudlay D., Kull I., Kupczyk M., Kvedariene V., Kyriakakou M., Lalek N., Lane S., Latiff A., Lau S., Lavrut J., Le L., Lessa M., Levin M., Li J., Lieberman P., Liotta G., Lipworth B., Liu X., Lobo R., Lodrup Carlsen K. C., Lombardi C., Louis R., Loukidis S., Lourenco O., Luna Pech J. A., Madjar B., Magnan A., Mahboub B., Mair A., Mais Y., Maitland Van Der Zee A. -H., Makela M., Makris M., Malling H. -J., Mandajieva M., Manning P., Manousakis M., Maragoudakis P., Marshall G., Martinsmartins P., Masjedi M. R., Maspero J. F., Matta Campos J. J., Maurer M., Mavale-Manuel S., Meco C., Melen E., Melo-Gomes E., Meltzer E. O., Menditto E., Menzies-Gow A., Merk H., Michel J. -P., Miculinic N., Midao L., Mihaltan F., Mikael K., Mikos N., Milenkovic B., Mitsias D., Moalla B., Moda G., Mogica Martinez M. D., Mohammad Y., Moin M., Molimard M., Momas I., Monaco A., Montefort S., Mora D., Morais-Almeida M., Mosges R., Mostafa B. E., Munter L., Muraro A., Murray R., Mustakov T., Naclerio R., Nadif R., Nakonechna A., Namazova-Baranova L., Navarro-Locsin G., Neffen H., Nekam K., Neou A., Nicod L., Niederberger-Leppin V., Niedoszytko M., Nieto A., Novellino E., Nunes E., Nyembue D., O'Hehir R., Odjakova C., Ohta K., Okamoto Y., Okubo K., Oliver B., Onorato G. L., Orru M. P., Ouedraogo S., Ouoba K., Paggiaro P. L., Pagkalos A., Palaniappan S. P., Pali-Scholl I., Palkonen S., Palmer S., Panaitescu Bunu C., Panzner P., Papanikolaou V., Papi A., Paralchev B., Paraskevopoulos G., Park H. S., Passalacqua G., Patella V., Pavord I., Pawankar R., Pedersen S., Peleve S., Pereira A., Perez T., Pham-Thi N., Pigearias B., Pin I., Piskou K., Pitsios C., Pitsios K., Plavec D., Poethig D., Pohl W., Poplas Susic A., Popov T. A., Portejoie F., Potter P., Poulsen L., Prados-Torres A., Prarros F., Price D., Prokopakis E., Puy R., Rabe K., Raciborski F., Ramos J., Recto M. T., Reda S. M., Regateiro F., Reider N., Reitsma S., Repka-Ramirez S., Rimmer J., Rivero Yeverino D., Rizzo J. A., Robalo-Cordeiro C., Roberts G., Roche N., Rodriguez Gonzalez M., Rodriguez Zagal E., Rolland C., Roller-Wirnsberger R., Roman Rodriguez M., Romano A., Rombaux P., Romualdez J., Rosado-Pinto J., Rosario N., Rosenwasser L., Rottem M., Rouadi P., Rovina N., Rozman Sinur I., Ruiz M., Ruiz Segura L. T., Ryan D., Sagara H., Sakai D., Sakurai D., Saleh W., Salimaki J., Salina H., Samitas K., Sanchez Coronel M. G., Sanchez-Borges M., Sanchez-Lopez J., Sarafoleanu C., Sarquis Serpa F., Sastre-Dominguez J., Scadding G., Scheire S., Schmid-Grendelmeier P., Schuhl J. F., Schunemann H., Schvalbova M., Scichilone N., Sepulveda C., Serrano E., Sheikh A., Shields M., Shishkov V., Siafakas N., Simeonov A., Simons E. F., Sisul J. C., Sitkauskiene B., Skrindo I., Soklic Kosak T., Sole D., Sooronbaev T., Soto-Martinez M., Sova M., Spertini F., Spranger O., Stamataki S., Stefanaki L., Stellato C., Stelmach R., Sterk P., Strandberg T., Stute P., Subramaniam A., Suppli Ulrik C., Sutherland M., Sylvestre S., Syrigou A., Taborda Barata L., Takovska N., Tan R., Tan F., Tan V., Tang I. P., Taniguchi M., Tannert L., Tattersall J., Teixeira M. D. C., Thijs C., Thomas M., To T., Todo-Bom A. M., Togias A., Tomazic P. -V., Toppila-Salmi S., Toskala E., Triggiani M., Triller N., Triller K., Tsiligianni I., Ulmeanu R., Urbancic J., Urrutia Pereira M., Vachova M., Valdes F., Valenta R., Valentin Rostan M., Valero A., Vallianatou M., Valovirta E., Van Eerd M., Van Ganse E., Van Hage M., Vandenplas O., Vasankari T., Vassileva D., Ventura M. T., Vera-Munoz C., Vicheva D., Vichyanond P., Vidgren P., Viegi G., Vogelmeier C., Von Hertzen L., Vontetsianos T., Vourdas D., Wagenmann M., Walker S., Wallace D., Wang D. Y., Waserman S., Wickman M., Williams S., Williams D., Wilson N., Woo K., Wright J., Wroczynski P., Xepapadaki P., Yakovliev P., Yamaguchi M., Yan K., Yap Y. Y., Yawn B., Yiallouros P., Yoshihara S., Young I., Yusuf O. B., Zaidi A., Zaitoun F., Zar H., Zernotti M., Zhang L., Zhong N., Zidarn M., Zubrinich C., UCL - (MGD) Service de pneumologie, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, Bousquet J., Anto J.M., Iaccarino G., Czarlewski W., Haahtela T., Anto A., Akdis C.A., Blain H., Canonica G.W., Cardona V., Cruz A.A., Illario M., Ivancevich J.C., Jutel M., Klimek L., Kuna P., Laune D., Larenas-linnemann D., Mullol J., Papadopoulos N.G., Pfaar O., Samolinski B., Valiulis A., Yorgancioglu A., Zuberbier T., Abdul Latiff A.H., Abdullah B., Aberer W., Abusada N., Adcock I., Afani A., Agache I., Aggelidis X., Agustin J., Akdis C., Akdis M., Al-Ahmad M., Bassam A.A.-Z., Aldrey-Palacios O., Cuesta E.A., Alzaabi A., Amad S., Ambrocio G., Annesi-Maesano I., Ansotegui I., Anto J., Arshad H., Artesani M.C., Asayag E., Avolio F., Azhari K., Baiardini I., Bajrovic N., Bakakos P., Mongono S.B., Balotro-Torres C., Barba S., Barbara C., Barbosa E., Barreto B., Bartra J., Bateman E.D., Battur L., Bedbrook A., Barajas M.B., Beghe B., Bel E., Kheder A.B., Benson M., Berghea C., Bergmann K.-C., Bernstein D., Bewick M., Bialek S., Bialoszewski A., Bieber T., Billo N., Bilo M.B., Bindslev-Jensen C., Bjermer L., Marciniak M.B., Bond C., Boner A., Bonini M., Bonini S., Bosnic-Anticevich S., Bosse I., Botskariova S., Bouchard J., Boulet L.-P., Bourret R., Bousquet P., Braido F., Briggs A., Brightling C., Brozek J., Buhl R., Bumbacea R., Cabanas M.T.B., Bush A., Busse W.W., Buters J., Caballero-Fonseca F., Calderon M.A., Calvo M., Camargos P., Camuzat T., Cano A., Capriles-Hulett A., Caraballo L., Carlsen K.-H., Caro J., Carr W., Carreon-Asun-cion F., Carriazo A.M., Casale T., Castor M.A., Castro E., Cecchi L., Sarabia A.C., Chandrasekharan R., Chang Y.-S., Chato-Andeza V., Chatzi L., Chatzidaki C., Chavannes N.H., Chen Y., Cheng L., Chivato T., Chkhartishvili E., Christoff G., Chrystyn H., Chu D.K., Chua A., Chuchalin A., Chung K.F., Ciceran A., Cingi C., Ciprandi G., Cirule I., Coelho A.C., Constantinidis J., de Sousa J.C., Costa E., Costa D., Dominguez M.C.C., Coste A., Cox L., Cullen J., Custovic A., Cvetkovski B., D'amato G., Silva J.D., Dahl R., Dahlen S.-E., Daniilidis V., Nahhas L.D., Darsow U., Blay F., Guia E.D., Santos C., Keenoy E.D.M., Vries G.D., Deleanu D., Demoly P., Denburg J., Devillier P., Didier A., Dimou M., Dinh-Xuan A.T., Djukanovic R., Dokic D., Dominguez Silva M.G., Douagui H., Douladiris N., Doulaptsi M., Dray G., Dubakiene R., Durham S., Dykewicz M., Ebo D., Edelbaher N., Eklund P., El-Gamal Y., El-Sayed Z.A., El-Sayed S.S., El-Seify M., Emuzyte R., Enecilla L., Espinoza H., Guillermo J., Contreras E., Farrell J., Fernandez L., Wagner A.F., Fiocchi A., Fokkens W.J., Fontaine J.-F., Forastiere F., Perez J.M.F., Gaerlan-resureccion E., Gaga M., Romero J.L.G., Gamkrelidze A., Garcia A., Cobas C.Y.G., Garcia Cruz M.L.L.H., Gayraud J., Gemicioglu B., Genova S., Gereda J., Wijk R.G., Gomez M., Diaz S.G., Gotua M., Grigoreas C., Grisle I., Guidacci M., Guldemond N., Gutter Z., Guzman A., Halloum R., Hamelmann E., Hammadi S., Harvey R., Heinrich J., Hejjaoui A., Hellquist-Dahl B., Velazquez L.H., Hew M., Hossny E., Howarth P., Hrubisko M., Villalobos Y.R.H., Humbert M., Hyland M., Ibrahim M., Ilyina N., Irani C., Ispayeva Z., Jares E., Jarvis D., Jassem E., Jenko K., Uscanga R.D.J., Johnston S., Joos G., Jost M., Julge K., Jung K.-S., Just J., Kaidashev I., Kalayci O., Kalyoncu F., Kapsali J., Kardas P., Karjalainen J., Kasala C.A., Katotomichelakis M., Kazi B., Keil T., Keith P., Khaitov M., Khaltaev N., Kim Y.-Y., Kleine-Tebbe J., Koffi N'Goran B., Kompoti E., Kopac P., Koppelman G., Jeverica A.K., Kosnik M., Kostov K.V., Kowalski M.L., Kralimarkova T., Vrscaj K.K., Kraxner H., Kreft S., Kritikos V., Kudlay D., Kull I., Kupczyk M., Kvedariene V., Kyriakakou M., Lalek N., Lane S., Larenas-Linnemann D., Latiff A., Lau S., Lavrut J., Le L., Lessa M., Levin M., Li J., Lieberman P., Liotta G., Lipworth B., Liu X., Lobo R., Lodrup Carlsen K.C., Lombardi C., Louis R., Loukidis S., Lourenco O., Luna Pech J.A., Madjar B., Magnan A., Mahboub B., Mair A., Mais Y., van der Zee A.-H.M., Makela M., Makris M., Malling H.-J., Mandajieva M., Manning P., Manousakis M., Maragoudakis P., Marshall G., Martins P., Reza Masjedi M., Maspero J.F., Campos J.J.M., Maurer M., Mavale-Manuel S., Meco C., Melen E., Melo-Gomes E., Meltzer E.O., Menditto E., Menzies-Gow A., Merk H., Michel J.-P., Miculinic N., Midao L., Mihaltan F., Mikael K., Mikos N., Milenkovic B., Mitsias D., Moalla B., Moda G., Martinez M.D.M., Mohammad Y., Moin M., Molimard M., Momas I., Monaco A., Montefort S., Mora D., Morais-Almeida M., Mosges R., Mostafa B.E., Munter L., Muraro A., Murray R., Mustakov T., Naclerio R., Nadif R., Nakonechna A., Namazova-Baranova L., Navarro-Locsin G., Neffen H., Nekam K., Neou A., Nicod L., Niederberger-Leppin V., Niedoszytko M., Nieto A., Novellino E., Nunes E., Nyembue D., O'hehir R., Odjakova C., Ohta K., Okamoto Y., Okubo K., Oliver B., Onorato G.L., Orru M.P., Ouedraogo S., Ouoba K., Paggiaro P.L., Pagkalos A., Palaniappan S.P., Pali-Scholl I., Palkonen S., Palmer S., Bunu C.P., Panzner P., Papanikolaou V., Papi A., Paralchev B., Paraskevopoulos G., Park H.S., Passalacqua G., Patella V., Pavord I., Pawankar R., Pedersen S., Peleve S., Pereira A., Perez T., Pham-Thi N., Pigearias B., Pin I., Piskou K., Pitsios C., Pitsios K., Plavec D., Poethig D., Pohl W., Susic A.P., Popov T.A., Portejoie F., Potter P., Poulsen L., Prados-Torres A., Prarros F., Price D., Prokopakis E., Puy R., Rabe K., Raciborski F., Ramos J., Recto M.T., Reda S.M., Regateiro F., Reider N., Reitsma S., Repka-Ramirez S., Rimmer J., Yeverino D.R., Rizzo J.A., Robalo-Cordeiro C., Roberts G., Roche N., Gonzalez M.R., Zagal E.R., Rolland C., Roller-Wirns-berger R., Rodriguez M.R., Romano A., Rombaux P., Romualdez J., Rosado-Pinto J., Rosario N., Rosenwasser L., Rottem M., Rouadi P., Rovina N., Sinur I.R., Ruiz M., Segura L.T.R., Ryan D., Sagara H., Sakai D., Sakurai D., Saleh W., Salimaki J., Salina H., Samitas K.-N., Coronel M.G.S., Sanchez-Borges M., Sanchez-Lopez J., Sarafoleanu C., Serpa F.S., Sastre-Dominguez J., Scadding G., Scheire S., Schmid-Grendelmeier P., Schuhl J.F., Schunemann H., Schvalbova M., Scichilone N., Sepulveda C., Serrano E., Sheikh A., Shields M., Shishkov V., Siafakas N., Simeonov A., Simons E.F., Sisul J.C., Sitkauskiene B., Skrindo I., Kosak T.S., Sole D., Sooronbaev T., Soto-Martinez M., Sova M., Spertini F., Spranger O., Stamataki S., Stefanaki L., Stellato C., Stelmach R., Sterk P., Strandberg T., Stute P., Subramaniam A., Suppli Ulrik C., Sutherland M., Sylvestre S., Syrigou A., Barata L.T., Takovska N., Tan R., Tan F., Tan V., Tang I.P., Taniguchi M., Tannert L., Tattersall J., Teixeira M.D.C., Thijs C., Thomas M., To T., Todo-Bom A.M., Togias A., Tomazic P.-V., Toppila-Salmi S., Toskala E., Triggiani M., Triller N., Triller K., Tsiligianni I., Ulmeanu R., Urbancic J., Pereira M.U., Vachova M., Valdes F., Valenta R., Rostan M.V., Valero A., Vallianatou M., Valovirta E., Eerd M.V., Ganse E.V., Hage M., Vandenplas O., Vasankari T., Vassileva D., Ventura T., Vera-Munoz C., Vicheva D., Vichyanond P., Vidgren P., Viegi G., Vogelmeier C., Hertzen L.V., Vontetsianos T., Vourdas D., Wagenmann M., Walker S., Wallace D., Wang D.Y., Waserman S., Wickman M., Williams S., Williams D., Wilson N., Woo K., Wright J., Wroczynski P., Xepapadaki P., Yakovliev P., Yamaguchi M., Yan K., Yap Y.Y., Yawn B., Yiallouros P., Yoshihara S., Young I., Yusuf O.B., Zaidi A., Zaitoun F., Zar H., Zernotti M., Zhang L., Zhong N., Zidarn M., Zubrinich C., Dubakienė, Rūta, Ėmužytė, Regina, Kvedarienė, Violeta, Bousquet, J., Anto, J. M., Iaccarino, G., Czarlewski, W., Haahtela, T., Anto, A., Akdis, C. A., Blain, H., Canonica, G. W., Cardona, V., Cruz, A. A., Illario, M., Ivancevich, J. C., Jutel, M., Klimek, L., Kuna, P., Laune, D., Larenas-Linnemann, D., Mullol, J., Papadopoulos, N. G., Pfaar, O., Samolinski, B., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Abdul Latiff, A. H., Abdullah, B., Aberer, W., Abusada, N., Adcock, I., Afani, A., Agache, I., Aggelidis, X., Agustin, J., Akdis, C., Akdis, M., Al-Ahmad, M., Al-Zahab Bassam, A., Aldrey-Palacios, O., Alvarez Cuesta, E., Alzaabi, A., Amad, S., Ambrocio, G., Annesi-Maesano, I., Ansotegui, I., Anto, J., Arshad, H., Artesani, M. C., Asayag, E., Avolio, F., Azhari, K., Baiardini, I., Bajrovic, N., Bakakos, P., Bakeyala Mongono, S., Balotro-Torres, C., Barba, S., Barbara, C., Barbosa, E., Barreto, B., Bartra, J., Bateman, E. 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H., Chen, Y., Cheng, L., Chivato, T., Chkhartishvili, E., Christoff, G., Chrystyn, H., Chu, D. K., Chua, A., Chuchalin, A., Chung, K. F., Ciceran, A., Cingi, C., Ciprandi, G., Cirule, I., Coelho, A. C., Constantinidis, J., Correia De Sousa, J., Costa, E., Costa, D., Costa Dominguez, M. D. C., Coste, A., Cox, L., Cullen, J., Custovic, A., Cvetkovski, B., D'Amato, G., Da Silva, J., Dahl, R., Dahlen, S. -E., Daniilidis, V., Darjazini Nahhas, L., Darsow, U., De Blay, F., De Guia, E., De Los Santos, C., De Manuel Keenoy, E., De Vries, G., Deleanu, D., Demoly, P., Denburg, J., Devillier, P., Didier, A., Dimou, M., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Dominguez Silva, M. G., Douagui, H., Douladiris, N., Doulaptsi, M., Dray, G., Dubakiene, R., Durham, S., Dykewicz, M., Ebo, D., Edelbaher, N., Eklund, P., El-Gamal, Y., El-Sayed, Z. A., El-Sayed, S. S., El-Seify, M., Emuzyte, R., Enecilla, L., Espinoza, H., Espinoza Contreras, J. G., Farrell, J., Fernandez, L., Fink Wagner, A., Fiocchi, A., Fokkens, W. J., Fontaine, J. -F., Forastiere, F., Fuentes Perez, J. M., Gaerlan-Resureccion, E., Gaga, M., Galvez Romero, J. L., Gamkrelidze, A., Garcia, A., Garcia Cobas, C. Y., Garcia Cruz, M. D. L. L. H., Gayraud, J., Gemicioglu, B., Genova, S., Gereda, J., Gerth Van Wijk, R., Gomez, M., Gonzalez Diaz, S., Gotua, M., Grigoreas, C., Grisle, I., Guidacci, M., Guldemond, N., Gutter, Z., Guzman, A., Halloum, R., Hamelmann, E., Hammadi, S., Harvey, R., Heinrich, J., Hejjaoui, A., Hellquist-Dahl, B., Hernandez Velazquez, L., Hew, M., Hossny, E., Howarth, P., Hrubisko, M., Huerta Villalobos, Y. R., Humbert, M., Hyland, M., Ibrahim, M., Ilyina, N., Irani, C., Ispayeva, Z., Jares, E., Jarvis, D., Jassem, E., Jenko, K., Jimeneracruz Uscanga, R. D., Johnston, S., Joos, G., Jost, M., Julge, K., Jung, K. -S., Just, J., Kaidashev, I., Kalayci, O., Kalyoncu, F., Kapsali, J., Kardas, P., Karjalainen, J., Kasala, C. A., Katotomichelakis, M., Kazi, B., Keil, T., Keith, P., Khaitov, M., Khaltaev, N., Kim, Y. -Y., Kleine-Tebbe, J., Koffi N'Goran, B., Kompoti, E., Kopac, P., Koppelman, G., Koren Jeverica, A., Kosnik, M., Kostov, K. V., Kowalski, M. L., Kralimarkova, T., Kramer Vrscaj, K., Kraxner, H., Kreft, S., Kritikos, V., Kudlay, D., Kull, I., Kupczyk, M., Kvedariene, V., Kyriakakou, M., Lalek, N., Lane, S., Latiff, A., Lau, S., Lavrut, J., Le, L., Lessa, M., Levin, M., Li, J., Lieberman, P., Liotta, G., Lipworth, B., Liu, X., Lobo, R., Lodrup Carlsen, K. C., Lombardi, C., Louis, R., Loukidis, S., Lourenco, O., Luna Pech, J. A., Madjar, B., Magnan, A., Mahboub, B., Mair, A., Mais, Y., Maitland Van Der Zee, A. -H., Makela, M., Makris, M., Malling, H. -J., Mandajieva, M., Manning, P., Manousakis, M., Maragoudakis, P., Marshall, G., Martinsmartins, P., Masjedi, M. R., Maspero, J. F., Matta Campos, J. J., Maurer, M., Mavale-Manuel, S., Meco, C., Melen, E., Melo-Gomes, E., Meltzer, E. O., Menditto, E., Menzies-Gow, A., Merk, H., Michel, J. -P., Miculinic, N., Midao, L., Mihaltan, F., Mikael, K., Mikos, N., Milenkovic, B., Mitsias, D., Moalla, B., Moda, G., Mogica Martinez, M. D., Mohammad, Y., Moin, M., Molimard, M., Momas, I., Monaco, A., Montefort, S., Mora, D., Morais-Almeida, M., Mosges, R., Mostafa, B. E., Munter, L., Muraro, A., Murray, R., Mustakov, T., Naclerio, R., Nadif, R., Nakonechna, A., Namazova-Baranova, L., Navarro-Locsin, G., Neffen, H., Nekam, K., Neou, A., Nicod, L., Niederberger-Leppin, V., Niedoszytko, M., Nieto, A., Novellino, E., Nunes, E., Nyembue, D., O'Hehir, R., Odjakova, C., Ohta, K., Okamoto, Y., Okubo, K., Oliver, B., Onorato, G. L., Orru, M. P., Ouedraogo, S., Ouoba, K., Paggiaro, P. L., Pagkalos, A., Palaniappan, S. P., Pali-Scholl, I., Palkonen, S., Palmer, S., Panaitescu Bunu, C., Panzner, P., Papanikolaou, V., Papi, A., Paralchev, B., Paraskevopoulos, G., Park, H. S., Passalacqua, G., Patella, V., Pavord, I., Pawankar, R., Pedersen, S., Peleve, S., Pereira, A., Perez, T., Pham-Thi, N., Pigearias, B., Pin, I., Piskou, K., Pitsios, C., Pitsios, K., Plavec, D., Poethig, D., Pohl, W., Poplas Susic, A., Popov, T. A., Portejoie, F., Potter, P., Poulsen, L., Prados-Torres, A., Prarros, F., Price, D., Prokopakis, E., Puy, R., Rabe, K., Raciborski, F., Ramos, J., Recto, M. T., Reda, S. M., Regateiro, F., Reider, N., Reitsma, S., Repka-Ramirez, S., Rimmer, J., Rivero Yeverino, D., Rizzo, J. A., Robalo-Cordeiro, C., Roberts, G., Roche, N., Rodriguez Gonzalez, M., Rodriguez Zagal, E., Rolland, C., Roller-Wirnsberger, R., Roman Rodriguez, M., Romano, A., Rombaux, P., Romualdez, J., Rosado-Pinto, J., Rosario, N., Rosenwasser, L., Rottem, M., Rouadi, P., Rovina, N., Rozman Sinur, I., Ruiz, M., Ruiz Segura, L. T., Ryan, D., Sagara, H., Sakai, D., Sakurai, D., Saleh, W., Salimaki, J., Salina, H., Samitas, K., Sanchez Coronel, M. G., Sanchez-Borges, M., Sanchez-Lopez, J., Sarafoleanu, C., Sarquis Serpa, F., Sastre-Dominguez, J., Scadding, G., Scheire, S., Schmid-Grendelmeier, P., Schuhl, J. F., Schunemann, H., Schvalbova, M., Scichilone, N., Sepulveda, C., Serrano, E., Sheikh, A., Shields, M., Shishkov, V., Siafakas, N., Simeonov, A., Simons, E. F., Sisul, J. C., Sitkauskiene, B., Skrindo, I., Soklic Kosak, T., Sole, D., Sooronbaev, T., Soto-Martinez, M., Sova, M., Spertini, F., Spranger, O., Stamataki, S., Stefanaki, L., Stellato, C., Stelmach, R., Sterk, P., Strandberg, T., Stute, P., Subramaniam, A., Suppli Ulrik, C., Sutherland, M., Sylvestre, S., Syrigou, A., Taborda Barata, L., Takovska, N., Tan, R., Tan, F., Tan, V., Tang, I. P., Taniguchi, M., Tannert, L., Tattersall, J., Teixeira, M. D. C., Thijs, C., Thomas, M., To, T., Todo-Bom, A. M., Togias, A., Tomazic, P. -V., Toppila-Salmi, S., Toskala, E., Triggiani, M., Triller, N., Triller, K., Tsiligianni, I., Ulmeanu, R., Urbancic, J., Urrutia Pereira, M., Vachova, M., Valdes, F., Valenta, R., Valentin Rostan, M., Valero, A., Vallianatou, M., Valovirta, E., Van Eerd, M., Van Ganse, E., Van Hage, M., Vandenplas, O., Vasankari, T., Vassileva, D., Ventura, M. T., Vera-Munoz, C., Vicheva, D., Vichyanond, P., Vidgren, P., Viegi, G., Vogelmeier, C., Von Hertzen, L., Vontetsianos, T., Vourdas, D., Wagenmann, M., Walker, S., Wallace, D., Wang, D. Y., Waserman, S., Wickman, M., Williams, S., Williams, D., Wilson, N., Woo, K., Wright, J., Wroczynski, P., Xepapadaki, P., Yakovliev, P., Yamaguchi, M., Yan, K., Yap, Y. Y., Yawn, B., Yiallouros, P., Yoshihara, S., Young, I., Yusuf, O. B., Zaidi, A., Zaitoun, F., Zar, H., Zernotti, M., Zhang, L., Zhong, N., Zidarn, M., Zubrinich, C., University of Zurich, Bousquet, Jean, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Berlin Institute of Health (BIH), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, IMIM-Hospital del Mar, Generalitat de Catalunya, Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), 'Federico II' University of Naples Medical School, Medical Consulting Czarlewski, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Euromov (EuroMov), Université de Montpellier (UM), IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy., Vall d'Hebron University Hospital [Barcelona], ProAR – Nucleo de Excelencia em Asma, Universidade Federal da Bahia (UFBA), Global Alliance Against Chronic Respiratory Diseases (GARD-WHO), Division for Health Innovation, Servicio de Alergia e ImmunologiaBuenos Aires (Clinica Santa Isabel), Wrocław Medical University, Center for Rhinology and Allergology Wiesbaden, University Hospital Mannheim, Barlicki University Hospital, KYomed INNOV [Montpellier], Hospital Medica Sur [Mexico City, Mexico], Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Royal Manchester Children's Hospital, University of Manchester [Manchester], General Children's Hospital of Athens P & A Kyriakou, Philipps Universität Marburg = Philipps University of Marburg, Medical University of Warsaw - Poland, Vilnius University [Vilnius], Manisa Celal Bayar University, and Salvy-Córdoba, Nathalie

Subjects
BLOOD-PRESSURE, Review, Angiotensin-converting enzyme, Antioxidant, Coronavirus, Diet, Food, law.invention, Dietary interventions, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, 10183 Swiss Institute of Allergy and Asthma Research, law, Medicine and Health Sciences, Immunology and Allergy, Medicine, 030212 general & internal medicine, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, education.field_of_study, Mortality rate, 3. Good health, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, 2723 Immunology and Allergy, Angiotensin-converting enzyme, Antioxidant, Coronavirus, Diet, Food, Pulmonary and Respiratory Medicine, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Coronaviru, Immunology, Population, 610 Medicine & health, COVID-19, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 03 medical and health sciences, Environmental health, population, angiotensin-converting enzyme, Quarantine, education, 2403 Immunology, ANTIHYPERTENSIVE PEPTIDES, business.industry, RC581-607, GENE, POLYMORPHISM, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, 030228 respiratory system, 2740 Pulmonary and Respiratory Medicine, Immunologic diseases. Allergy, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Regional differences, Coronavirus Infections
Abstract

Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be significant are the dietary habits. It seems that some foods largely used in these countries may reduce angiotensin-converting enzyme activity or are anti-oxidants. Among the many possible areas of research, it might be important to understand diet and angiotensin-converting enzyme-2 (ACE2) levels in populations with different COVID-19 death rates since dietary interventions may be of great benefit.

Published
2020

27. Autres antiasthmatiques

Author

Legeay, S., primary, Faure, S., additional, Muller, B., additional, Michel, V., additional, and Molimard, M., additional

Published
2016
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28. Les auteurs

Author

Bellien, J., primary, Cracowski, J.-L., additional, Ambrosi, P., additional, Andréjak, M., additional, Angoulvant, D., additional, Atkinson, C., additional, Barau, C., additional, Bedouch, P., additional, Bejan-Angoulvant, T., additional, Bellien, J., additional, Benevent, J., additional, Berreni, A., additional, Berthat, V., additional, Bourgeois, A.-L., additional, Bousquet, P., additional, Boutouyrie, P., additional, Bricca†, G., additional, Chaumais, M.-C., additional, Despas, F., additional, Donazzolo, Y., additional, Faure, S., additional, Funck-Bretano, C., additional, Gueyffier, F., additional, Ghaleh, B., additional, Lamoureux, F., additional, Laporte, S., additional, Laviolle, B., additional, Legeay, S., additional, Lotiron, C., additional, Michel, V., additional, Mismetti, P., additional, Molimard, M., additional, Monassier, L., additional, Montani, D., additional, Muller, B., additional, Pathak, A., additional, Picard, N., additional, Plotkine, M., additional, Pons, S., additional, Ribuot, C., additional, Richard, V., additional, Roustit, M., additional, Senard, J.-M., additional, Ternant, D., additional, and Timour, Q., additional

Published
2016
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30. EurOP2E – the European open platform for prescribing education, a consensus study among clinical pharmacology and therapeutics teachers

Author

Bakkum, Michiel J., Richir, Milan C., Papaioannidou, Paraskevi, Likic, Robert, Sanz, Emilio J., Christiaens, Thierry, Costa, João N., Maciulaitis, Romaldas, Dima, Lorena, Coleman, Jamie, Tichelaar, Jelle, van Agtmael, Michiel A., Atanasova, Ivanka, Ganeva, Maria, Gatchev, Emil, Kostadinova, I.I., Matanovic, S. Mimica, Vitezic, D., Wozniak, Greta, Kmonickova, E., Urbanek, Karel, Damkier, P., Huupponen, R. K., Auffret, Marine, Bejan-Angoulvant, T., Chouchana, Laurent, Cracowski, Jean-Luc, Drici, M. D., Faillie, J. L., Geniaux, Hélène, Molimard, M., Orlikowski, D., Palin, Karine, Pers, Y-M, Picard, Nicolas, Simon, N., Toussirot, E., Boger, R. H., Cascorbi, I., Mueller, S. C., Regenthal, R., Schwab, M., Schwaninger, M. S., Thuermann, P. A., Wojnowski, L., Kouvelas, D., Riba, P., Kerins, David M., Williams, David J., Cosentino, M., De Ponti, Fabrizio, Filippelli, Amelia, Leone, R., Locatelli, Vittorio, Jansone, Baiba, Gulbinovic, Romaldas, Mifsud, Janet, Braszko, Jan J., Kocic, I., Breitenfeld, Luiza, Castelo-Branco, M., Conea, Simona, Magyar, Ioan, Bevc, S., Krzan, Mojca, Bernal, M. L., Capellà, D., Carcas, A., De Abajo, F. J., Lopez-Rico, M., Lucena, M. I., Pontes, C., Sanz, E. J., Böttiger, Y., Le Grevès, Madeleine, de Waard-Siebinga, I., Janssen, Ben J. A., Knol, Wilma, Pandit, Rahul, van Rosse, F., Dent, G., Ferro, Albert, Hitchings, A. W., Kapil, V., Linton, K. D., Loke, Y. K., Okorie, Michael, Plumb, Richard David, Pontefract, Sarah, Ranmuthu, S., Sampson, A. P., Thanacoody, H. K. R., Whitfield, Jonathan P., Wilson, Kurt, Bakkum M.J., Richir M.C., Papaioannidou P., Likic R., Sanz E.J., Christiaens T., Costa J.N., Maciulaitis R., Dima L., Coleman J., Tichelaar J., van Agtmael M.A., Atanasova I., Ganeva M., Gatchev E., Kostadinova I.I., Matanovic S.M., Vitezic D., Wozniak G., Kmonickova E., Urbanek K., Damkier P., Huupponen R.K., Auffret M., Bejan-Angoulvant T., Chouchana L., Cracowski J.-L., Drici M.D., Faillie J.L., Geniaux H., Molimard M., Orlikowski D., Palin K., Pers Y.-M., Picard N., Simon N., Toussirot E., Boger R.H., Cascorbi I., Mueller S.C., Regenthal R., Schwab M., Schwaninger M.S., Thuermann P.A., Wojnowski L., Kouvelas D., Riba P., Kerins D.M., Williams D.J., Cosentino M., De Ponti F., Filippelli A., Leone R., Locatelli V., Jansone B., Gulbinovic R., Mifsud J., Braszko J.J., Kocic I., Breitenfeld L., Castelo-Branco M., Conea S., Magyar I., Bevc S., Krzan M., Bernal M.L., Capella D., Carcas A., De Abajo F.J., Lopez-Rico M., Lucena M.I., Pontes C., Bottiger Y., Le Greves M., de Waard-Siebinga I., Janssen B.J.A., Knol W., Pandit R., van Rosse F., Dent G., Ferro A., Hitchings A.W., Kapil V., Linton K.D., Loke Y.K., Okorie M., Plumb R.D., Pontefract S., Ranmuthu S., Sampson A.P., Thanacoody H.K.R., Whitfield J.P., Wilson K., Internal medicine, Other Research, CCA - Cancer Treatment and quality of life, Bakkum, M, Richir, M, Papaioannidou, P, Likic, R, Sanz, E, Christiaens, T, Costa, J, Mačiulaitis, R, Dima, L, Coleman, J, Tichelaar, J, van Agtmael, M, and Locatelli, V

Subjects
Medical education, Open platform, Quality management, Pharmacoepidemiology and Prescription, Teaching Materials, media_common.quotation_subject, Language barrier, 030226 pharmacology & pharmacy, Open educational resources, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Political science, Copyright, ComputingMilieux_COMPUTERSANDEDUCATION, Humans, Pharmacology (medical), Quality (business), Cooperative Behavior, Adaptation (computer science), Schools, Medical, media_common, Pharmacology, Clinical pharmacology, 05 social sciences, Open educational resource, 050301 education, General Medicine, Quality Improvement, Clinical pharmacology and therapeutic, Europe, Digital education, Educational resources, Pharmacology, Clinical, clinical pharmacology and therapeutics, digital education, medical education, open educational resources, 0503 education, Clinical pharmacology and therapeutics, Human
Abstract

Purpose Sharing and developing digital educational resources and open educational resources has been proposed as a way to harmonize and improve clinical pharmacology and therapeutics (CPT) education in European medical schools. Previous research, however, has shown that there are barriers to the adoption and implementation of open educational resources. The aim of this study was to determine perceived opportunities and barriers to the use and creation of open educational resources among European CPT teachers and possible solutions for these barriers. Methods CPT teachers of British and EU medical schools completed an online survey. Opportunities and challenges were identified by thematic analyses and subsequently discussed in an international consensus meeting. Results Data from 99 CPT teachers from 95 medical schools were analysed. Thirty teachers (30.3%) shared or collaboratively produced digital educational resources. All teachers foresaw opportunities in the more active use of open educational resources, including improving the quality of their teaching. The challenges reported were language barriers, local differences, lack of time, technological issues, difficulties with quality management, and copyright restrictions. Practical solutions for these challenges were discussed and include a peer review system, clear indexing, and use of copyright licenses that permit adaptation of resources. Conclusion Key challenges to making greater use of CPT open educational resources are a limited applicability of such resources due to language and local differences and quality concerns. These challenges may be resolved by relatively simple measures, such as allowing adaptation and translation of resources and a peer review system.

Published
2021

33. MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation

Author

Bousquet, J., Schunemann, H. J., Fonseca, J., Samolinski, B., Bachert, C., Canonica, G. W., Casale, T., Cruz, A. A., Demoly, P., Hellings, P., Valiulis, A., Wickman, M., Zuberbier, T., Bosnic-Anticevitch, S., Bedbrook, A., Bergmann, K. C., Caimmi, D., Dahl, R., Fokkens, W. J., Grisle, I., Carlsen, Lodrup K., Mullol, J., Muraro, A., Palkonen, S., Papadopoulos, N., Passalacqua, G., Ryan, D., Valovirta, E., Yorgancioglu, A., Aberer, W., Agache, I., Adachi, M., Akdis, C. A., Akdis, M., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielhe, S., Arshad, H., Baiardini, I., Baigenzhin, A. K., Barbara, C., Bateman, E. D., Beghé, B., Bel, E. H., Ben Kheder, A., Bennoor, K. S., Benson, M., Bewick, M., Bieber, T., Bindslev-Jensen, C., Bjermer, L., Blain, H., Boner, A. L., Boulet, L. P., Bonini, M., Bonini, S., Bosse, I., Bourret, R., Bousquet, P. J., Braido, F., Briggs, A. H., Brightling, C. E., Brozek, J., Buhl, R., Burney, P. G., Bush, A., Caballero-Fonseca, F., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Carlsen, K. H., Carr, W., Cepeda Sarabia, A. M., Chavannes, N. H., Chatzi, L., Chen, Y. Z., Chiron, R., Chkhartishvili, E., Chuchalin, A. G., Ciprandi, G., Cirule, I., de Sousa, Correia J., Cox, L., Crooks, G., Costa, D. J., Custovic, A., Dahlen, S. E., Darsow, U., De Carlo, G., De Blay, F., Dedeu, T., Deleanu, D., Denburg, J. A., Devillier, P., Didier, A., Dinh-Xuan, A. T., Dokic, D., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., Emuzyte, R., Wagner, Fink A., Fletcher, M., Fiocchi, A., Forastiere, F., Gamkrelidze, A., Gemicioğlu, B., Gereda, J. E., Diaz, González S., Gotua, M., Grouse, L., Guzmán, M. A., Haahtela, T., Hellquist-Dahl, B., Heinrich, J., Horak, F., Hourihane, J. O.‘B., Howarth, P., Humbert, M., Hyland, M. E., Ivancevich, J. C., Jares, E. J., Johnston, S. L., Joos, G., Jonquet, O., Jung, K. S., Just, J., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Keil, T., Keith, P. K., Khaltaev, N., Klimek, L., NʼGoran, Koffi B., Kolek, V., Koppelman, G. H., Kowalski, M. L., Kull, I., Kuna, P., Kvedariene, V., Lambrecht, B., Lau, S., Larenas-Linnemann, D., Laune, D., Le, L. T. T., Lieberman, P., Lipworth, B., Li, J., Louis, R., Magard, Y., Magnan, A., Mahboub, B., Majer, I., Makela, M. J., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Maurer, M., Mavale-Manuel, S., Melén, E., Melo-Gomes, E., Meltzer, E. O., Merk, H., Miculinic, N., Mihaltan, F., Milenkovic, B., Mohammad, Y., Molimard, M., Momas, I., Montilla-Santana, A., Morais-Almeida, M., Mösges, R., Namazova-Baranova, L., Naclerio, R., Neou, A., Neffen, H., Nekam, K., Niggemann, B., Nyembue, T. D., OʼHehir, R. E., Ohta, K., Okamoto, Y., Okubo, K., Ouedraogo, S., Paggiaro, P., Pali-Schöll, I., Palmer, S., Panzner, P., Papi, A., Park, H. S., Pavord, I., Pawankar, R., Pfaar, O., Picard, R., Pigearias, B., Pin, I., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Postma, D., Potter, P., Price, D., Rabe, K. F., Raciborski, F., Pontal, Radier F., Repka-Ramirez, S., Robalo-Cordeiro, C., Rolland, C., Rosado-Pinto, J., Reitamo, S., Rodenas, F., Rodriguez, Roman M., Romano, A., Rosario, N., Rosenwasser, L., Rottem, M., Sanchez-Borges, M., Scadding, G. K., Serrano, E., Schmid-Grendelmeier, P., Sheikh, A., Simons, F. E. R., Sisul, J. C., Skrindo, I., Smit, H. A., Solé, D., Sooronbaev, T., Spranger, O., Stelmach, R., Strandberg, T., Sunyer, J., Thijs, C., Todo-Bom, A., Triggiani, M., Valenta, R., Valero, A. L., van Hage, M., Vandenplas, O., Vezzani, G., Vichyanond, P., Viegi, G., Wagenmann, M., Walker, S., Wang, D. Y., Wahn, U., Williams, D. M., Wright, J., Yawn, B. P., Yiallouros, P. K., Yusuf, O. M., Zar, H. J., Zernotti, M. E., Zhang, L., Zhong, N., Zidarn, M., and Mercier, J.

Published
2015
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34. Harmonizing and improving European education in prescribing: An overview of digital educational resources used in clinical pharmacology and therapeutics

Author

Bakkum, Michiel J., Tichelaar, Jelle, Papaioannidou, Paraskevi, Likic, Robert, Sanz Alvarez, Emilio J., Christiaens, Thierry, Costa, João N., Mačiulaitis, Romaldas, Dima, Lorena, Coleman, Jamie, Richir, Milan C., Agtmael, Michiel A., Atanasova, Ivanka, Ganeva, Maria, Gatchev, Emil, Kostadinova, I. I., Mimica Matanovic, S., Vitezic, D, Greta, Wozniak, Kmonickova, E., Karel, Urbanek, Damkier, P., Huupponen, R. K., Auffret, Marine, Bejan‐ Angoulvant, T., Laurent, Chouchana, Jean‐Luc, Cracowski, Drici, M. D., Faillie, J. L., Hélène, Geniaux, Molimard, M., Orlikowski, D., Palin, Karine, Pers, Y.‐M., Picard, Nicolas, Simon, N., Toussirot, E., Boger, R. H., Cascorbi, I., Mueller, S. C., Regenthal, R., Schwab, M., Schwaninger, M. S., Thuermann, P. A., Wojnowski, L., Kouvelas, D., Riba, P., Kerins, David M., Williams, David J., Cosentino, M., De Ponti, Fabrizio, Filippelli, Amelia, Leone, R., Locatelli, Vittorio, Jansone, Baiba, Gulbinovic, Romaldas, Mifsud, Janet, Braszko Jan, J., Kocic, I., Luiza, Breitenfeld, Castelo‐Branco, M., Simona, Conea, Ioan, Magyar, Bevc, S., Mojca, Krzan, Bernal, M. L., Capellà, D., Carcas, A., De Abajo, F. J., Lopez‐Rico, M., Lucena, M. I., Pontes, C., Sanz, E. J., Böttiger, Y., Le Grevès, Madeleine, Waard‐Siebinga, I., Janssen Ben, J. A., Wilma, Knol, Rahul, Pandit, Rosse, F., Dent, G., Albert, Ferro, Hitchings, A. W., Kapil, V., Linton, K. D., Loke, Y. K., Michael, Okorie, David, Plumb Richard, Pontefract, Sarah, Ranmuthu, S., Sampson, A. P., Thanacoody, H. K. R., Whitfield Jonathan, P., Wilson, Kurt, for the Education Working Group of the European Association for Clinical Pharmacology and Therapeutics (EACPT) and its affiliated Network of Teachers in Pharmacotherapy (NOTIP), Bakkum, M, Tichelaar, J, Papaioannidou, P, Likic, R, Sanz Alvarez, E, Christiaens, T, Costa, J, Mačiulaitis, R, Dima, L, Coleman, J, Richir, M, van Agtmael, M, Locatelli, V, Internal medicine, Other Research, Bakkum M.J., Tichelaar J., Papaioannidou P., Likic R., Sanz Alvarez E.J., Christiaens T., Costa J.N., Maciulaitis R., Dima L., Coleman J., Richir M.C., van Agtmael M.A., Atanasova I., Ganeva M., Gatchev E., Kostadinova I.I., Mimica Matanovic S., Vitezic D., Greta W., Kmonickova E., Karel U., Damkier P., Huupponen R.K., Auffret M., Bejan-Angoulvant T., Laurent C., Jean-Luc C., Drici M.D., Faillie J.L., Helene G., Molimard M., Orlikowski D., Palin K., Pers Y.-M., Picard N., Simon N., Toussirot E., Boger R.H., Cascorbi I., Mueller S.C., Regenthal R., Schwab M., Schwaninger M.S., Thuermann P.A., Wojnowski L., Kouvelas D., Riba P., Kerins D.M., Williams D.J., Cosentino M., De Ponti F., Filippelli A., Leone R., Locatelli V., Jansone B., Gulbinovic R., Mifsud J., Braszko Jan J., Kocic I., Luiza B., Castelo-Branco M., Simona C., Ioan M., Bevc S., Mojca K., Bernal M.L., Capella D., Carcas A., De Abajo F.J., Lopez-Rico M., Lucena M.I., Pontes C., Bottiger Y., Le Greves M., de Waard-Siebinga I., Janssen Ben J.A., Wilma K., Rahul P., van Rosse F., Dent G., Albert F., Hitchings A.W., Kapil V., Linton K.D., Loke Y.K., Michael O., David P.R., Pontefract S., Ranmuthu S., Sampson A.P., Thanacoody H.K.R., Whitfield Jonathan P., and Wilson K.

Subjects
Computer-Assisted Instruction, Harmonization, 030226 pharmacology & pharmacy, law.invention, open educational resource, 03 medical and health sciences, 0302 clinical medicine, Medicaments -- Prescripció, law, clinical pharmacology and therapeutic, Humans, Learning, Pharmacology (medical), Narrative, 030212 general & internal medicine, Curriculum, Schools, Medical, Cross-Sectional Studie, Pharmacology, education, Medical education, Prescribing, clinical pharmacology and therapeutics, digital, open educational resources, Clinical pharmacology, Drugs -- Prescribing, Principal (computer security), Open educational resources, Variety (cybernetics), Cross-Sectional Studies, Pharmacology, Clinical, Psychology, Human
Abstract

CONTRIBUTORS IN THE NETWORK OF TEACHERS IN PHARMACOTHERAPY (NOTIP) (ALPHABETIZED BY COUNTRY): Atanasova, Ivanka (Sofia University St. Kliment Ohridski, Sofia, Bulgaria); Ganeva, Maria (Trakia University, Stara Zagora, Bulgaria); Gatchev, Emil (Medical University of Sofia, Sofia, Bulgaria); Kostadinova, II (Medical University Plovdiv, Plovdiv, Bulgaria); Mimica Matanovic, S (University of Osijek, Osijek, Croatia); Vitezic, D (University of Rijeka Medical School, Rijeka, Croatia); Wozniak, Greta (University of Cyprus, Nicosia, Cyprus); Kmonickova, E (Charles University, Pilsen, Czech Republic); Urbanek, Karel (Palacky University, Olomouc, Czech Republic); Damkier, P (University of Southern Denmark, Odense, Denmark); Huupponen, RK (University of Turku, Turku, Finland); Auffret, Marine (Hospices civils de Lyon, Lyon, France); Bejan-Angoulvant, T (Université de Tours, Tours, France); Chouchana, Laurent (Hospital Cochin, Paris, France); Cracowski, Jean-Luc (University Grenoble Alpes, La Tronche, France); Drici, MD (University of Nice Côte d'Azur, Nice, France); Faillie, JL (CHU Montpellier, Montpellier, France); Geniaux, Hélène (CHU de Limoges, Limoges, France); Molimard, M (Université de Bordeaux, Bordeaux, France); Orlikowski, D (Versailles Saint-Quentin-en-Yvelines University, Versailles, France); Palin, Karine (University of Bordeaux, Bordeaux, France); Pers, Y-M (CHU Montpellier, Montpellier, France); Picard, Nicolas (CHU de Limoges, Limoges, France); Simon, N (Aix-Marseille University, Marseille, France); Toussirot, E (CHU de Besancon, Besancon, France); Boger, RH (University Medical Center Hamburg-Eppendorf, Hamburg, Germany); Cascorbi, I (University of Kiel, Kiel, Germany); Mueller, SC (University Medicine Rostock, Rostock, Germany); Regenthal, R (University of Leipzig, Leipzig, Germany); Schwab, M (Eberhard Karl University of Tübingen, Tübingen, Germany); Schwaninger, MS (University of Luebeck, Luebeck, Germany); Thuermann, PA (University Witten/Herdecke, Witten, Germany); Wojnowski, L (University Medical Center Mainz, Mainz, Germany); Kouvelas, D (Aristotle University of Thessaloniki, Thessaloniki, Greece); Riba, P (Semmelweis University, Budapest, Hungary); Kerins, David M (University College, Cork, Ireland); Williams, David J (Royal College of Surgeons in Ireland, Dublin, Ireland); Cosentino, M (University of Insubria, Varese, Italy); De Ponti, Fabrizio (University of Bologna, Bologna, Italy); Filippelli, Amelia (University of Salerno, Baronissi, Italy); Leone, R (University of Verona, Verona, Italy); Locatelli, Vittorio (University of Milano - Bicocca, Monza, Italy); Jansone, Baiba (University of Latvia, Riga, Latvia); Gulbinovic, Romaldas (Vilnius University, Vilnius, Lithuania); Mifsud, Janet (University of Malta, Msida, Malta); Braszko, Jan J (Medical University of Bialystok, Bialystok, Poland); kocic, I (Medical University of Gdansk, Gdansk, Poland); Breitenfeld, Luiza (Beira Interior University, Covilh~a, Portugal); Castelo-Branco, M (University of Beira Interior, Covilh~a, Portugal); Conea, Simona (“Vasile Goldis” Western University of Arad, Arad, Romania); Magyar, Ioan (University of Oradea, Oradea, Romania); Bevc, S (University of Maribor, Maribor, Slovenia); Krzan, Mojca (University of Ljubljana, Ljubljana, Slovenia); Bernal, ML (University of Zaragoza, Zaragoza, Spain); Capellà, D (University of Girona, Girona, Spain); Carcas, A (Universidad Autónoma de Madrid, University of Maribor, Spain); De Abajo, FJ (University of Alcalá, Alcalá de Henares, Spain); Lopez-Rico, M (University of Salamanca, Salamanca, Spain); Lucena, MI (University of Malaga, Malaga, Spain); Pontes, C (Universitat Autonoma de Barcelona, Sabadell, Spain); Sanz, EJ (Universidad de La Laguna, La Laguna, Spain); Böttiger, Y (Linköping University, Linköping, Sweden); Le Grevès, Madeleine (Uppsala University, Uppsala, Sweden); de Waard-Siebinga, I (University Medical Center Groningen, Groningen, The Netherlands); Janssen, Ben JA (Maastricht University, Maastricht, The Netherlands); Knol, Wilma (University Medical Center Utrecht, Utrecht, The Netherlands); Pandit, Rahul (University Medical Center Utrecht, Utrecht, The Netherlands); van Rosse, F (Erasmus Medical Center, Rotterdam, The Netherlands); Dent, G (Keele University, Keele, United Kingdom); Ferro, Albert (King's College London, London, United Kingdom); Hitchings, AW (St George's, University of London, London, United Kingdom); Kapil, V (Queen Mary University London, London, United Kingdom); Linton, KD (University of Sheffield, Sheffield, United Kingdom); Loke, YK (University of East Anglia, Norwich, United Kingdom); Okorie, Michael (Brighton and Sussex Medical School, Brighton, United Kingdom); Plumb, Richard David (Queen's University Belfast, Belfast, United Kingdom); Pontefract, Sarah (University of Birmingham, Birmingham, United Kingdom); Ranmuthu, S (Queen Mary University London, London, United Kingdom); Sampson, AP (University of Southampton, Southampton, United Kingdom); Thanacoody, HKR (Newcastle University, Newcastle upon Tyne, United Kingdom); Whitfield, Jonathan P (University of Aberdeen, Aberdeen, United Kingdom); Wilson, Kurt (University of Manchester, Manchester, United Kingdom) Improvement and harmonization of European clinical pharmacology and therapeutics (CPT) education is urgently required. Because digital educational resources can be easily shared, adapted to local situations and re‐used widely across a variety of educational systems, they may be ideally suited for this purpose Methods With a cross‐sectional survey among principal CPT teachers in 279 out of 304 European medical schools, an overview and classification of digital resources was compiled. Results Teachers from 95 (34%) medical schools in 26 of 28 EU countries responded, 66 (70%) of whom used digital educational resources in their CPT curriculum. A total of 89 of such resources were described in detail, including e‐learning (24%), simulators to teach pharmacokinetics and/or pharmacodynamics (10%), virtual patients (8%), and serious games (5%). Together, these resources covered 235 knowledge‐based learning objectives, 88 skills, and 13 attitudes. Only one third (27) of the resources were in‐part or totally free and only two were licensed open educational resources (free to use, distribute and adapt). A narrative overview of the largest, free and most novel resources is given. Conclusion Digital educational resources, ranging from e‐learning to virtual patients and games, are widely used for CPT education in EU medical schools. Learning objectives are based largely on knowledge rather than skills or attitudes. This may be improved by including more real‐life clinical case scenarios. Moreover, the majority of resources are neither free nor open. Therefore, with a view to harmonizing international CPT education, more needs to be learned about why CPT teachers are not currently sharing their educational materials.

Published
2020

35. Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: a multicohort European case–control study using centralized ultrasensitive 454 pyrosequencing

Author

Cozzi-Lepri, Alessandro, Noguera-Julian, Marc, Di Giallonardo, Francesca, Schuurman, Rob, Däumer, Martin, Aitken, Sue, Ceccherini-Silberstein, Francesca, DʼArminio Monforte, Antonella, Geretti, Anna Maria, Booth, Clare L., Kaiser, Rolf, Michalik, Claudia, Jansen, Klaus, Masquelier, Bernard, Bellecave, Pantxika, Kouyos, Roger D., Castro, Erika, Furrer, Hansjakob, Schultze, Anna, Günthard, Huldrych F., Brun-Vezinet, Francoise, Paredes, Roger, Metzner, Karin J., Paredes, Roger, Metzner, Karin J., Cozzi-Lepri, Alessandro, Schuurman, Rob, Brun-Vezinet, Francoise, Günthard, Huldrych, Ceccherini-Silberstein, Francesca, Kaiser, Rolf, Geretti, Anna Maria, Brockmeyer, Norbert, Masquelier, Bernard, Dabis, F., Bruyand, M., Chêne, G., Dabis, F., Lawson-Ayayi, S., Thiébaut, R., Wittkop, L., André, K., Bonnal, F., Bonnet, F., Bernard, N., Caunègre, L., Cazanave, C., Ceccaldi, J., Chossat, I., Courtaud, K., Dauchy, F. A., De Witte, S., Dupon, M., Dupont, A., Duffau, P., Dutronc, H., Farbos, S., Gaborieau, V., Gemain, M. C., Gerard, Y., Greib, C., Hessamfar, M., Lacoste, D., Lataste, P., Lazaro, E., Longy-Boursier, M., Malvy, D., Meraud, J. P., Mercié, P., Monlun, E., Morlat, P., Neau, D., Ochoa, A., Pellegrin, J. L., Pistone, T., Receveur, M. C., Schmeltz, J. Roger, Tchamgoué, S., Vandenhende, M. A., Vareil, M.O., Viallard, J. F., Moreau, J. F., Pellegrin, I., Fleury, H., Lafon, M. E., Masquelier, B., Reigadas, S., Trimoulet, P., Bouchet, S., Breilh, D., Molimard, M., Titier, K., Haramburu, F., Miremont-Salamé., G., Blaizeau, M. J., Decoin, M., Delaune, J., Delveaux, S., DʼIvernois, C., Hanapier, C., Leleux, O., Lenaud, E., Uwamaliya-Nziyumvira, B., Sicard, X., Geffard, S., Le Marec, F., Conte, V., Frosch, A., Leray, J., Palmer, G., Touchard, D., Bonnet, F., Breilh, D., Chêne, G., Dabis, F., Dupon, M., Fleury, H., Malvy, D., Mercié, P., Morlat, P., Neau, D., Pellegrin, I., Pellegrin, J. L., Bouchet, S., Gaborieau, V., Lacoste, D., Tchamgoué, S., Thiébaut, R., Losso, M., Kundro, M., Ramos Mejia, J. M., Vetter, N., Zangerle, R., Karpov, I., Vassilenko, A., Mitsura, V. M., Suetnov, O., Clumeck, N., De Wit, S., Delforge, M., Florence, E., Vandekerckhove, L., Hadziosmanovic, V., Kostov, K., Begovac, J., Machala, L., Jilich, D., Sedlacek, D., Nielsen, J., Kronborg, G., Benfield, T., Larsen, M., Gerstoft, J., Katzenstein, T., Hansen, A.-B. E., Skinhøj, P., Pedersen, C., Ostergaard, L., Dragsted, U. B., Nielsen, L. N., Zilmer, K., Smidt, Jelena, Ristola, M., Katlama, C., Viard, J. P., Girard, P. M., Vanhems, P., Pradier, C., Dabis, F., Neau, D., Duvivier, C., Rockstroh, J., Schmidt, R., van Lunzen, J., Degen, O., Stellbrink, H. J., Bickel, M., Bogner, J., Fätkenheuer, G., Kosmidis, J., Gargalianos, P., Xylomenos, G., Perdios, J., Sambatakou, H., Banhegyi, D., Gottfredsson, M., Mulcahy, F., Yust, I., Turner, D., Burke, M., Pollack, S., HassounRambam, G., Elinav, H., HaouziHadassah, M., EspositoI, R., Mazzotta, F., Vullo, V., Moroni, M., Andreoni, M., Angarano, G., Antinori, A., Castelli, F., Cauda, R., Di Perri, G., Galli, M., Iardino, R., Ippolito, G., Lazzarin, A., Perno, C. F., von Schloesser, F., Viale, P., Monforte, A. DʼArminio, Antinori, A., Castagna, A., Ceccherini-Silberstein, F., Cozzi-Lepri, A., Girardi, E., Lo Caputo, S., Mussini, C., Puoti, M., Andreoni, M., Ammassari, A., Antinori, A., Balotta, C., Bonfanti, P., Bonora, S., Borderi, M., Capobianchi, M. R., Castagna, A., Ceccherini-Silberstein, F., Cingolani, A., Cinque, P., Cozzi-Lepri, A., De Luca, A., Di Biagio, A., Girardi, E., Gianotti, N., Gori, A., Guaraldi, G., Lapadula, G., Lichtner, M., Lo Caputo, S., Madeddu, G., Maggiolo, F., Marchetti, G., Marcotullio, S., Monno, L., Mussini, C., Puoti, M., Quiros Roldan, E., Rusconi, S., Cozzi-Lepri, A., Cicconi, P., Fanti, I., Formenti, T., Galli, L., Lorenzini, P., Carletti, F., Carrara, S., Castrogiovanni, A., Di Caro, A., Petrone, F., Prota, G., Quartu, S., Giacometti, A., Costantini, A., Mazzoccato, S., Angarano, G., Monno, L., Santoro, C., Maggiolo, F., Suardi, C., Viale, P., Vanino, E., Verucchi, G., Castelli, F., Quiros Roldan, E., Minardi, C., Quirino, T., Abeli, C., Manconi, P. E., Piano, P., Vecchiet, J., Falasca, K., Sighinolfi, L., Segala, D., Mazzotta, F., Lo Caputo, S., Cassola, G., Viscoli, C., Alessandrini, A., Piscopo, R., Mazzarello, G., Mastroianni, C., Belvisi, V., Bonfanti, P., Caramma, I., Chiodera, A., Castelli, A. P., Galli, M., Lazzarin, A., Rizzardini, G., Puoti, M., DʼArminio Monforte, A., Ridolfo, A. L., Piolini, R., Castagna, A., Salpietro, S., Carenzi, L., Moioli, M. C., Tincati, C., Marchetti, G., Mussini, C., Puzzolante, C., Gori, A., Lapadula, G., Abrescia, N., Chirianni, A., Guida, M. G., Gargiulo, M., Baldelli, F., Francisci, D., Parruti, G., Ursini, T., Magnani, G., Ursitti, M. A., Cauda, R., Andreoni, M., Antinori, A., Vullo, V., Cingolani, A., dʼAvino, A., Gallo, L., Nicastri, E., Acinapura, R., Capozzi, M., Libertone, R., Tebano, G., Cattelan, A., Sasset, L., Mura, M. S., Madeddu, G., De Luca, A., Rossetti, B., Caramello, P., Di Perri, G., Orofino, G. C., Bonora, S., Sciandra, M., Bassetti, M., Londero, A., Pellizzer, G., Manfrin, V., Brockmeyer, N. H., Skaletz-Rorowski, A., Dupke, S., Baumgarten, A., Carganico, A., Köppe, S., Kreckel, P., Lauenroth-Mai, E., Freiwald-Rausch, M., Gölz, J., Moll, A., Zeitz, M., Hower, M., Reuter, S., Jensen, B., Harrer, T., Esser, S., Brodt, H. R., Plettenberg, A., Stöhr, A., Buhk, T., Stellbrink, H. J., Stoll, M., Schmidt, R., Kuhlmann, B., Mosthaf, F. A., Rieke, A., Becker, W., Volkert, R., Jäger, H., Hartl, H., Mutz, A., Ulmer, A., Müller, M., Aubert, V., Barth, J., Battegay, M., Bernasconi, E., Böni, J., Bucher, H. C., Burton-Jeangros, C., Calmy, A., Cavassini, M., Egger, M., Elzi, L., Fehr, J., Fellay, J., Furrer, H., Fux, C. A., Gorgievski, M., Günthard, H., Haerry, D., Hasse, B., Hirsch, H. H., Hösli, I., Kahlert, C., Kaiser, L., Keiser, O., Klimkait, T., Kovari, H., Kouyos, R., Ledergerber, B., Martinetti, G., Martinez de Tejada, B., Metzner, K., Müller, N., Nadal, D., Pantaleo, G., Rauch, A., Regenass, S., Rickenbach, M., Rudin, C., Schmid, P., Schultze, D., Schöni-Affolter, F., Schüpbach, J., Speck, R., Staehelin, C., Tarr, P., Telenti, A., Trkola, A., Vernazza, P., Weber, R., and Yerly, S.

Published
2015
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39. Key Learning Outcomes for Clinical Pharmacology and Therapeutics Education in Europe: A Modified Delphi Study

Author

Brinkman, D, Tichelaar, J, Mokkink, L, Christiaens, T, Likic, R, Maciulaitis, R, Costa, J, Sanz, E, Maxwell, S, Richir, M, Van, A, Michiel A., L, Kostadinova, I, Ganeva, M, Atanasova, I, Gatchev, E, Stavreva, G, Vitezic, D, Matanovic, S, Wozniak, G, Nicolaou, P, Urbanek, K, Slanar, O, Kmonickova, E, Demlova, R, Bergmann, T, Damkier, P, Kalda, A, Huupponen, R, Backman, J, Drici, M, Deplanque, D, Molimard, M, Toussirot, E, Pers, Y, Bertin, P, Laviolle, B, Jeunne, C, Saulnier, P, Chamontin, B, Roustit, M, Orlikowski, D, Simon, N, Dequin, P, Angoulvant, T, Bolbrinker, J, Wojnowski, L, Cascorbi, I, Müller, F, Müller, S, Schwaninger, M, Neumann, J, Stümpel, F, Regenthal, R, Fuhr, U, Thürmann, P, Eirini, A, Papaioannidou, P, Kouvelas, D, Kolios, G, Riba, P, Kerins, D, Williams, D, Harnett, A, Spina, E, Fumagalli, G, Filippelli, A, Benemei, S, De Ponti, F, Cosentino, M, Locatelli, V, De Montis, M, Memo, M, Raschi, E, Purvina, S, Gulbinovic, J, Mifsud, J, Keijsers, K, Rissmann, R, Dumont, G, van Rosse, F, Spigset, O, Opdal, M, Braszko, J, Mirowska-Guzel, D, Broncel, M, Kocic, I, Sousa, M, Monteiro, E, Dima, L, Magyar, I, Conea, S, Buzoianu, A, Glasova, H, Tisonova, J, Glasa, J, Krzan, M, Saez-Penataro, J, de Abajo Iglesias, F, Capella, D, Figuerola, F, Sansuan, A, Lopez-Rico, M, Manso, G, Benitez, J, Lucena, M, Bernal, M, Cladellas, X, Hernandez, R, Pontes, C, Panagiotidis, G, Böttiger, Y, Wallerstedt, S, Eriksson, A, Desmeules, J, Krähenbühl, S, Plumb, R, Okorie, M, Wilson, K, Mckay, G, Sofat, R, Kapil, V, Whitfield, J, Thanacoody, R, Mir, F, Loke, Y, Schachter, M, O'Brien, L, Heep, A, Brinkman, David J, Tichelaar, Jelle, Mokkink, Lidwine B, Christiaens, Thierry, Likic, Robert, Maciulaitis, Romaldas, Costa, Joao, Sanz, Emilio J, Maxwell, Simon R, Richir, Milan C, van Agtmael, Michiel A. Lefebvre R, Kostadinova I, Ganeva M, Atanasova I, Gatchev E, Stavreva G, Vitezic D, Matanovic S, Wozniak G, Nicolaou P, Urbanek K, Slanar O, Kmonickova E, Demlova R, Bergmann T, Damkier P, Kalda A, Huupponen R, Backman J, Drici MD, Deplanque D, Molimard M, Toussirot E, Pers YM, Bertin P, Laviolle B, Jeunne CL, Saulnier PJ, Chamontin B, Roustit M, Orlikowski D, Simon N, Dequin PF, Angoulvant T, Bolbrinker J, Wojnowski L, Cascorbi I, Müller F, Müller S, Schwaninger M, Neumann J, Stümpel F, Regenthal R, Fuhr U, Thürmann P, Eirini A, Papaioannidou P, Kouvelas D, Kolios G, Riba P, Kerins D, Williams D, Harnett A, Spina E, Fumagalli G, Filippelli A, Benemei S, De Ponti F, Cosentino M, Locatelli V, De Montis MG, Memo M, Raschi E, Purvina S, Gulbinovic J, Mifsud J, Keijsers K, Rissmann R, Dumont G, van Rosse F, Spigset O, Opdal MS, Braszko J, Mirowska-Guzel D, Broncel M, Kocic I, Sousa MC, Monteiro E, Dima L, Magyar I, Conea S, Buzoianu A, Glasova H, Tisonova J, Glasa J, Krzan M, Saez-Penataro J, de Abajo Iglesias FJ, Capella D, Figuerola FAH, Sansuan AJC, Lopez-Rico M, Manso G, Benitez J, Lucena MI, Bernal ML, Cladellas XC, Hernandez RA, Pontes C, Panagiotidis G, Böttiger Y, Wallerstedt S, Eriksson A, Desmeules J, Krähenbühl S, Plumb R, Okorie M, Wilson K, McKay G, Sofat R, Kapil V, Whitfield J, Thanacoody R, Mir F, Loke Y, Schachter M, O'Brien L, Heep A, Brinkman, D, Tichelaar, J, Mokkink, L, Christiaens, T, Likic, R, Maciulaitis, R, Costa, J, Sanz, E, Maxwell, S, Richir, M, Van, A, Michiel A., L, Kostadinova, I, Ganeva, M, Atanasova, I, Gatchev, E, Stavreva, G, Vitezic, D, Matanovic, S, Wozniak, G, Nicolaou, P, Urbanek, K, Slanar, O, Kmonickova, E, Demlova, R, Bergmann, T, Damkier, P, Kalda, A, Huupponen, R, Backman, J, Drici, M, Deplanque, D, Molimard, M, Toussirot, E, Pers, Y, Bertin, P, Laviolle, B, Jeunne, C, Saulnier, P, Chamontin, B, Roustit, M, Orlikowski, D, Simon, N, Dequin, P, Angoulvant, T, Bolbrinker, J, Wojnowski, L, Cascorbi, I, Müller, F, Müller, S, Schwaninger, M, Neumann, J, Stümpel, F, Regenthal, R, Fuhr, U, Thürmann, P, Eirini, A, Papaioannidou, P, Kouvelas, D, Kolios, G, Riba, P, Kerins, D, Williams, D, Harnett, A, Spina, E, Fumagalli, G, Filippelli, A, Benemei, S, De Ponti, F, Cosentino, M, Locatelli, V, De Montis, M, Memo, M, Raschi, E, Purvina, S, Gulbinovic, J, Mifsud, J, Keijsers, K, Rissmann, R, Dumont, G, van Rosse, F, Spigset, O, Opdal, M, Braszko, J, Mirowska-Guzel, D, Broncel, M, Kocic, I, Sousa, M, Monteiro, E, Dima, L, Magyar, I, Conea, S, Buzoianu, A, Glasova, H, Tisonova, J, Glasa, J, Krzan, M, Saez-Penataro, J, de Abajo Iglesias, F, Capella, D, Figuerola, F, Sansuan, A, Lopez-Rico, M, Manso, G, Benitez, J, Lucena, M, Bernal, M, Cladellas, X, Hernandez, R, Pontes, C, Panagiotidis, G, Böttiger, Y, Wallerstedt, S, Eriksson, A, Desmeules, J, Krähenbühl, S, Plumb, R, Okorie, M, Wilson, K, Mckay, G, Sofat, R, Kapil, V, Whitfield, J, Thanacoody, R, Mir, F, Loke, Y, Schachter, M, O'Brien, L, Heep, A, Brinkman, David J, Tichelaar, Jelle, Mokkink, Lidwine B, Christiaens, Thierry, Likic, Robert, Maciulaitis, Romaldas, Costa, Joao, Sanz, Emilio J, Maxwell, Simon R, Richir, Milan C, van Agtmael, Michiel A. Lefebvre R, Kostadinova I, Ganeva M, Atanasova I, Gatchev E, Stavreva G, Vitezic D, Matanovic S, Wozniak G, Nicolaou P, Urbanek K, Slanar O, Kmonickova E, Demlova R, Bergmann T, Damkier P, Kalda A, Huupponen R, Backman J, Drici MD, Deplanque D, Molimard M, Toussirot E, Pers YM, Bertin P, Laviolle B, Jeunne CL, Saulnier PJ, Chamontin B, Roustit M, Orlikowski D, Simon N, Dequin PF, Angoulvant T, Bolbrinker J, Wojnowski L, Cascorbi I, Müller F, Müller S, Schwaninger M, Neumann J, Stümpel F, Regenthal R, Fuhr U, Thürmann P, Eirini A, Papaioannidou P, Kouvelas D, Kolios G, Riba P, Kerins D, Williams D, Harnett A, Spina E, Fumagalli G, Filippelli A, Benemei S, De Ponti F, Cosentino M, Locatelli V, De Montis MG, Memo M, Raschi E, Purvina S, Gulbinovic J, Mifsud J, Keijsers K, Rissmann R, Dumont G, van Rosse F, Spigset O, Opdal MS, Braszko J, Mirowska-Guzel D, Broncel M, Kocic I, Sousa MC, Monteiro E, Dima L, Magyar I, Conea S, Buzoianu A, Glasova H, Tisonova J, Glasa J, Krzan M, Saez-Penataro J, de Abajo Iglesias FJ, Capella D, Figuerola FAH, Sansuan AJC, Lopez-Rico M, Manso G, Benitez J, Lucena MI, Bernal ML, Cladellas XC, Hernandez RA, Pontes C, Panagiotidis G, Böttiger Y, Wallerstedt S, Eriksson A, Desmeules J, Krähenbühl S, Plumb R, Okorie M, Wilson K, McKay G, Sofat R, Kapil V, Whitfield J, Thanacoody R, Mir F, Loke Y, Schachter M, O'Brien L, and Heep A

Abstract

Harmonizing clinical pharmacology and therapeutics (CPT) education in Europe is necessary to ensure that the prescribing competency of future doctors is of a uniform high standard. As there are currently no uniform requirements, our aim was to achieve consensus on key learning outcomes for undergraduate CPT education in Europe. We used a modified Delphi method consisting of three questionnaire rounds and a panel meeting. A total of 129 experts from 27 European countries were asked to rate 307 learning outcomes. In all, 92 experts (71%) completed all three questionnaire rounds, and 33 experts (26%) attended the meeting. 232 learning outcomes from the original list, 15 newly suggested and 5 rephrased outcomes were included. These 252 learning outcomes should be included in undergraduate CPT curricula to ensure that European graduates are able to prescribe safely and effectively. We provide a blueprint of a European core curriculum describing when and how the learning outcomes might be acquired.

Published
2018

40. Correction to: Is diet partly responsible for differences in COVID-19 death rates between and within countries? (Clinical and Translational Allergy, (2020), 10, 1, (16), 10.1186/s13601-020-00323-0)

Author

Bousquet, J. Anto, J.M. Iaccarino, G. Czarlewski, W. Haahtela, T. Anto, A. Akdis, C.A. Blain, H. Canonica, G.W. Cardona, V. Cruz, A.A. Illario, M. Ivancevich, J.C. Jutel, M. Klimek, L. Kuna, P. Laune, D. Larenas-linnemann, D. Mullol, J. Papadopoulos, N.G. Pfaar, O. Samolinski, B. Valiulis, A. Yorgancioglu, A. Zuberbier, T. Latiff, A.H.A. Abdullah, B. Aberer, W. Abusada, N. Adcock, I. Afani, A. Agache, I. Aggelidis, X. Agustin, J. Akdis, C. Akdis, M. Al-Ahmad, M. Bassam, A.A.-Z. Aldrey-Palacios, O. Cuesta, E.A. Alzaabi, A. Amad, S. Ambrocio, G. Annesi-Maesano, I. Ansotegui, I. Anto, J. Arshad, H. Artesani, M.C. Asayag, E. Avolio, F. Azhari, K. Baiardini, I. Bajrović, N. Bakakos, P. Mongono, S.B. Balotro-Torres, C. Barba, S. Barbara, C. Barbosa, E. Barreto, B. Bartra, J. Bateman, E.D. Battur, L. Bedbrook, A. Barajas, M.B. Beghé, B. Bel, E. Kheder, A.B. Benson, M. Berghea, C. Bergmann, K.-C. Bernstein, D. Bewick, M. Bialek, S. Białoszewski, A. Bieber, T. Billo, N. Bilo, M.B. Bindslev-Jensen, C. Bjermer, L. Blain, H. Marciniak, M.B. Bond, C. Boner, A. Bonini, M. Bonini, S. Bosnic-Anticevich, S. Bosse, I. Botskariova, S. Bouchard, J. Boulet, L.-P. Bourret, R. Bousquet, P. Braido, F. Briggs, A. Brightling, C. Brozek, J. Buhl, R. Bumbacea, R. Cabañas, M.T.B. Bush, A. Busse, W.W. Buters, J. Caballero-Fonseca, F. Calderon, M.A. Calvo, M. Camargos, P. Camuzat, T. Cano, A. Capriles-Hulett, A. Caraballo, L. Cardona, V. Carlsen, K.-H. Caro, J. Carr, W. Carreon-Asun-cion, F. Carriazo, A.M. Casale, T. Castor, M.A. Castro, E. Cecchi, L. Sarabia, A.C. Chandrasekharan, R. Chang, Y.-S. Chato-Andeza, V. Chatzi, L. Chatzidaki, C. Chavannes, N.H. Chen, Y. Cheng, L. Chivato, T. Chkhartishvili, E. Christoff, G. Chrystyn, H. Chu, D.K. Chua, A. Chuchalin, A. Chung, K.F. Cicerán, A. Cingi, C. Ciprandi, G. Cirule, I. Coelho, A.C. Constantinidis, J. Sousa, J.C. Costa, E. Costa, D. Domínguez, M.C.C. Coste, A. Cox, L. Cruz, A.A. Cullen, J. Custovic, A. Cvetkovski, B. Czarlewski, W. D’amato, G. Silva, J.D. Dahl, R. Dahlen, S.-E. Daniilidis, V. Nahhas, L.D. Darsow, U. Blay, F. Guia, E.D. Santos, C. Keenoy, E.D.M. Vries, G.D. Deleanu, D. Demoly, P. Denburg, J. Devillier, P. Didier, A. Dimou, M. Dinh-Xuan, A.T. Djukanovic, R. Dokic, D. Silva, M.G.D. Douagui, H. Douladiris, N. Doulaptsi, M. Dray, G. Dubakiene, R. Durham, S. Dykewicz, M. Ebo, D. Edelbaher, N. Eklund, P. El-Gamal, Y. El-Sayed, Z.A. El-Sayed, S.S. El-Seify, M. Emuzyte, R. Enecilla, L. Espinoza, H. Farrell, J. Fernandez, L. Wagner, A.F. Fiocchi, A. Fokkens, W.J. Fontaine, J.-F. Forastiere, F. Fuentes, J.M. Gaerlan–resureccion, E. Gaga, M. Romero, J.L.G. Gamkrelidze, A. Garcia, A. Cobas, C.Y.G. Gayraud, J. Gemicioglu, B. Genova, S. Gereda, J. Wijk, R.G. Gomez, M. Diaz, S.G. Gotua, M. Grigoreas, C. Grisle, I. Guidacci, M. Guldemond, N. Gutter, Z. Guzmán, A. Haahtela, T. Halloum, R. Hamelmann, E. Hammadi, S. Harvey, R. Heinrich, J. Hejjaoui, A. Hellquist-Dahl, B. Velázquez, L.H. Hew, M. Hossny, E. Howarth, P. Hrubiško, M. Villalobos, Y.R.H. Humbert, M. Hyland, M. Iaccarino, G. Ibrahim, M. Illario, M. Ilyina, N. Irani, C. Ispayeva, Z. Ivancevich, J.C. Jares, E. Jarvis, D. Jassem, E. Jenko, K. Uscanga, R.D.J. Johnston, S. Joos, G. Jošt, M. Julge, K. Jung, K.-S. Just, J. Jutel, M. Kaidashev, I. Kalayci, O. Kalyoncu, F. Kapsali, J. Kardas, P. Karjalainen, J. Kasala, C.A. Katotomichelakis, M. Kazi, B. Keil, T. Keith, P. Khaitov, M. Khaltaev, N. Kim, Y.-Y. Kleine-Tebbe, J. Klimek, L. Koffi N’Goran, B. Kompoti, E. Kopač, P. Koppelman, G. Jeverica, A.K. Košnik, M. Kostov, K.V. Kowalski, M.L. Kralimarkova, T. Vrščaj, K.K. Kraxner, H. Kreft, S. Kritikos, V. Kudlay, D. Kull, I. Kuna, P. Kupczyk, M. Kvedariene, V. Kyriakakou, M. Lalek, N. Lane, S. Larenas-Linnemann, D. Latiff, A. Lau, S. Laune, D. Lavrut, J. Le, L. Lessa, M. Levin, M. Li, J. Lieberman, P. Liotta, G. Lipworth, B. Liu, X. Lobo, R. Lodrup Carlsen, K.C. Lombardi, C. Louis, R. Loukidis, S. Lourenço, O. Luna Pech, J.A. Madjar, B. Magnan, A. Mahboub, B. Mair, A. Mais, Y. van der Zee, A.-H.M. Makela, M. Makris, M. Malling, H.-J. Mandajieva, M. Manning, P. Manousakis, M. Maragoudakis, P. Marshall, G. Martins, P. Masjedi, M.R. Máspero, J.F. Campos, J.J.M. Maurer, M. Mavale-Manuel, S. Meço, C. Melén, E. Melo-Gomes, E. Meltzer, E.O. Menditto, E. Menzies-Gow, A. Merk, H. Michel, J.-P. Miculinic, N. Midão, L. Mihaltan, F. Mikael, K. Mikos, N. Milenkovic, B. Mitsias, D. Moalla, B. Moda, G. Martínez, M.D.M. Mohammad, Y. Moin, M. Molimard, M. Momas, I. Monaco, A. Montefort, S. Mora, D. Morais-Almeida, M. Mösges, R. Mostafa, B.E. Mullol, J. Münter, L. Muraro, A. Murray, R. Mustakov, T. Naclerio, R. Nadif, R. Nakonechna, A. Namazova-Baranova, L. Navarro-Locsin, G. Neffen, H. Nekam, K. Neou, A. Nicod, L. Niederberger-Leppin, V. Niedoszytko, M. Nieto, A. Novellino, E. Nunes, E. Nyembue, D. O’hehir, R. Odjakova, C. Ohta, K. Okamoto, Y. Okubo, K. Oliver, B. Onorato, G.L. Orru, M.P. Ouédraogo, S. Ouoba, K. Paggiaro, P.L. Pagkalos, A. Palaniappan, S.P. Pali-Schöll, I. Palkonen, S. Palmer, S. Bunu, C.P. Panzner, P. Papadopoulos, N.G. Papanikolaou, V. Papi, A. Paralchev, B. Paraskevopoulos, G. Park, H.S. Passalacqua, G. Patella, V. Pavord, I. Pawankar, R. Pedersen, S. Peleve, S. Pereira, A. Pérez, T. Pfaar, O. Pham-Thi, N. Pigearias, B. Pin, I. Piskou, K. Pitsios, C. Pitsios, K. Plavec, D. Poethig, D. Pohl, W. Susic, A.P. Popov, T.A. Portejoie, F. Potter, P. Poulsen, L. Prados-Torres, A. Prarros, F. Price, D. Prokopakis, E. Puy, R. Rabe, K. Raciborski, F. Ramos, J. Recto, M.T. Reda, S.M. Regateiro, F. Reider, N. Reitsma, S. Repka-Ramirez, S. Rimmer, J. Yeverino, D.R. Rizzo, J.A. Robalo-Cordeiro, C. Roberts, G. Roche, N. González, M.R. Zagal, E.R. Rolland, C. Roller-Wirns-berger, R. Rodriguez, M.R. Romano, A. Rombaux, P. Romualdez, J. Rosado-Pinto, J. Rosario, N. Rosenwasser, L. Rottem, M. Rouadi, P. Rovina, N. Sinur, I.R. Ruiz, M. Segura, L.T.R. Ryan, D. Sagara, H. Sakai, D. Sakurai, D. Saleh, W. Salimaki, J. Salina, H. Samitas, K.-N. Coronel, M.G.S. Sanchez-Borges, M. Sanchez-Lopez, J. Sarafoleanu, C. Serpa, F.S. Sastre-Dominguez, J. Scadding, G. Scheire, S. Schmid-Grendelmeier, P. Schuhl, J.F. Schunemann, H. Schvalbová, M. Scichilone, N. Sepúlveda, C. Serrano, E. Sheikh, A. Shields, M. Shishkov, V. Siafakas, N. Simeonov, A. Simons, E.F. Sisul, J.C. Sitkauskiene, B. Skrindo, I. Soklič, T. Solé, D. Sooronbaev, T. Soto-Martinez, M. Sova, M. Spertini, F. Spranger, O. Stamataki, S. Stefanaki, L. Stellato, C. Stelmach, R. Sterk, P. Strandberg, T. Stute, P. Subramaniam, A. Ulrik, C.S. Sutherland, M. Sylvestre, S. Syrigou, A. Barata, L.T. Takovska, N. Tan, R. Tan, F. Tan, V. Tang, I.P. Taniguchi, M. Tannert, L. Tattersall, J. Teixeira, M.D.C. Thijs, C. Thomas, M. To, T. Todo-Bom, A.M. Togias, A. Tomazic, P.-V. Toppila-Salmi, S. Toskala, E. Triggiani, M. Triller, N. Triller, K. Tsiligianni, I. Ulmeanu, R. Urbancic, J. Pereira, M.U. Vachova, M. Valdés, F. Valenta, R. Rostan, M.V. Valero, A. Valiulis, A. Vallianatou, M. Valovirta, E. Eerd, M.V. Ganse, E.V. Hage, M. Vandenplas, O. Vasankari, T. Vassileva, D. Ventura, M.T. Vera-Munoz, C. Vicheva, D. Vichyanond, P. Vidgren, P. Viegi, G. Vogelmeier, C. Hertzen, L.V. Vontetsianos, T. Vourdas, D. Wagenmann, M. Walker, S. Wallace, D. Wang, D.Y. Waserman, S. Wickman, M. Williams, S. Williams, D. Wilson, N. Woo, K. Wright, J. Wroczynski, P. Xepapadaki, P. Yakovliev, P. Yamaguchi, M. Yan, K. Yap, Y.Y. Yawn, B. Yiallouros, P. Yorgancioglu, A. Yoshihara, S. Young, I. Yusuf, O.B. Zaidi, A. Zaitoun, F. Zar, H. Zernotti, M. Zhang, L. Zhong, N. Zidarn, M. Zuberbier, T.

Abstract

Following publication of the original article [1], the authors identified an error in the affiliation list. The affiliation of author G. Walter Canonica should have been split up into two affiliations: • Personalized Medicine, Asthma and Allergy – Humanitas Clinical and Research Center – IRCCS, Rozzano (MI), Italy • Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy The corrected affiliation list is reflected in this Correction. © 2020, The Author(s).

Published
2020

41. Correction to: Is diet partly responsible for differences in COVID-19 death rates between and within countries? (Clinical and Translational Allergy, (2020), 10, 1, (16), 10.1186/s13601-020-00323-0)

Author

Bousquet, J., Anto, J. M., Iaccarino, G., Czarlewski, W., Haahtela, T., Anto, A., Akdis, C. A., Blain, H., Canonica, G. W., Cardona, V., Cruz, A. A., Illario, M., Ivancevich, J. C., Jutel, M., Klimek, L., Kuna, P., Laune, D., Larenas-linnemann, D., Mullol, J., Papadopoulos, N. G., Pfaar, O., Samolinski, B., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Latiff, A. H. A., Abdullah, B., Aberer, W., Abusada, N., Adcock, I., Afani, A., Agache, I., Aggelidis, X., Agustin, J., Akdis, C., Akdis, M., Al-Ahmad, M., Bassam, A. A. -Z., Aldrey-Palacios, O., Cuesta, E. A., Alzaabi, A., Amad, S., Ambrocio, G., Annesi-Maesano, I., Ansotegui, I., Anto, J., Arshad, H., Artesani, M. C., Asayag, E., Avolio, F., Azhari, K., Baiardini, I., Bajrovic, N., Bakakos, P., Mongono, S. B., Balotro-Torres, C., Barba, S., Barbara, C., Barbosa, E., Barreto, B., Bartra, J., Bateman, E. D., Battur, L., Bedbrook, A., Barajas, M. B., Beghe, B., Bel, E., Kheder, A. B., Benson, M., Berghea, C., Bergmann, K. -C., Bernstein, D., Bewick, M., Bialek, S., Bialoszewski, A., Bieber, T., Billo, N., Bilo, M. B., Bindslev-Jensen, C., Bjermer, L., Marciniak, M. B., Bond, C., Boner, A., Bonini, M., Bonini, S., Bosnic-Anticevich, S., Bosse, I., Botskariova, S., Bouchard, J., Boulet, L. -P., Bourret, R., Bousquet, P., Braido, F., Briggs, A., Brightling, C., Brozek, J., Buhl, R., Bumbacea, R., Cabanas, M. T. B., Bush, A., Busse, W. W., Buters, J., Caballero-Fonseca, F., Calderon, M. A., Calvo, M., Camargos, P., Camuzat, T., Cano, A., Capriles-Hulett, A., Caraballo, L., Carlsen, K. -H., Caro, J., Carr, W., Carreon-Asun-cion, F., Carriazo, A. M., Casale, T., Castor, M. A., Castro, E., Cecchi, L., Sarabia, A. C., Chandrasekharan, R., Chang, Y. -S., Chato-Andeza, V., Chatzi, L., Chatzidaki, C., Chavannes, N. H., Chen, Y., Cheng, L., Chivato, T., Chkhartishvili, E., Christoff, G., Chrystyn, H., Chu, D. K., Chua, A., Chuchalin, A., Chung, K. F., Ciceran, A., Cingi, C., Ciprandi, G., Cirule, I., Coelho, A. C., Constantinidis, J., Sousa, J. C., Costa, E., Costa, D., Dominguez, M. C. C., Coste, A., Cox, L., Cullen, J., Custovic, A., Cvetkovski, B., D'Amato, G., Silva, J. D., Dahl, R., Dahlen, S. -E., Daniilidis, V., Nahhas, L. D., Darsow, U., Blay, F., Guia, E. D., Santos, C., Keenoy, E. D. M., Vries, G. D., Deleanu, D., Demoly, P., Denburg, J., Devillier, P., Didier, A., Dimou, M., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Silva, M. G. D., Douagui, H., Douladiris, N., Doulaptsi, M., Dray, G., Dubakiene, R., Durham, S., Dykewicz, M., Ebo, D., Edelbaher, N., Eklund, P., El-Gamal, Y., El-Sayed, Z. A., El-Sayed, S. S., El-Seify, M., Emuzyte, R., Enecilla, L., Espinoza, H., Farrell, J., Fernandez, L., Wagner, A. F., Fiocchi, A., Fokkens, W. J., Fontaine, J. -F., Forastiere, F., Fuentes, J. M., Gaerlan-resureccion, E., Gaga, M., Romero, J. L. G., Gamkrelidze, A., Garcia, A., Cobas, C. Y. G., Gayraud, J., Gemicioglu, B., Genova, S., Gereda, J., Wijk, R. G., Gomez, M., Diaz, S. G., Gotua, M., Grigoreas, C., Grisle, I., Guidacci, M., Guldemond, N., Gutter, Z., Guzman, A., Halloum, R., Hamelmann, E., Hammadi, S., Harvey, R., Heinrich, J., Hejjaoui, A., Hellquist-Dahl, B., Velazquez, L. H., Hew, M., Hossny, E., Howarth, P., Hrubisko, M., Villalobos, Y. R. H., Humbert, M., Hyland, M., Ibrahim, M., Ilyina, N., Irani, C., Ispayeva, Z., Jares, E., Jarvis, D., Jassem, E., Jenko, K., Uscanga, R. D. J., Johnston, S., Joos, G., Jost, M., Julge, K., Jung, K. -S., Just, J., Kaidashev, I., Kalayci, O., Kalyoncu, F., Kapsali, J., Kardas, P., Karjalainen, J., Kasala, C. A., Katotomichelakis, M., Kazi, B., Keil, T., Keith, P., Khaitov, M., Khaltaev, N., Kim, Y. -Y., Kleine-Tebbe, J., Koffi N'Goran, B., Kompoti, E., Kopac, P., Koppelman, G., Jeverica, A. K., Kosnik, M., Kostov, K. V., Kowalski, M. L., Kralimarkova, T., Vrscaj, K. K., Kraxner, H., Kreft, S., Kritikos, V., Kudlay, D., Kull, I., Kupczyk, M., Kvedariene, V., Kyriakakou, M., Lalek, N., Lane, S., Larenas-Linnemann, D., Latiff, A., Lau, S., Lavrut, J., Le, L., Lessa, M., Levin, M., Li, J., Lieberman, P., Liotta, G., Lipworth, B., Liu, X., Lobo, R., Lodrup Carlsen, K. C., Lombardi, C., Louis, R., Loukidis, S., Lourenco, O., Luna Pech, J. A., Madjar, B., Magnan, A., Mahboub, B., Mair, A., Mais, Y., van der Zee, A. -H. M., Makela, M., Makris, M., Malling, H. -J., Mandajieva, M., Manning, P., Manousakis, M., Maragoudakis, P., Marshall, G., Martins, P., Masjedi, M. R., Maspero, J. F., Campos, J. J. M., Maurer, M., Mavale-Manuel, S., Meco, C., Melen, E., Melo-Gomes, E., Meltzer, E. O., Menditto, E., Menzies-Gow, A., Merk, H., Michel, J. -P., Miculinic, N., Midao, L., Mihaltan, F., Mikael, K., Mikos, N., Milenkovic, B., Mitsias, D., Moalla, B., Moda, G., Martinez, M. D. M., Mohammad, Y., Moin, M., Molimard, M., Momas, I., Monaco, A., Montefort, S., Mora, D., Morais-Almeida, M., Mosges, R., Mostafa, B. E., Munter, L., Muraro, A., Murray, R., Mustakov, T., Naclerio, R., Nadif, R., Nakonechna, A., Namazova-Baranova, L., Navarro-Locsin, G., Neffen, H., Nekam, K., Neou, A., Nicod, L., Niederberger-Leppin, V., Niedoszytko, M., Nieto, A., Novellino, E., Nunes, E., Nyembue, D., O'Hehir, R., Odjakova, C., Ohta, K., Okamoto, Y., Okubo, K., Oliver, B., Onorato, G. L., Orru, M. P., Ouedraogo, S., Ouoba, K., Paggiaro, P. L., Pagkalos, A., Palaniappan, S. P., Pali-Scholl, I., Palkonen, S., Palmer, S., Bunu, C. P., Panzner, P., Papanikolaou, V., Papi, A., Paralchev, B., Paraskevopoulos, G., Park, H. S., Passalacqua, G., Patella, V., Pavord, I., Pawankar, R., Pedersen, S., Peleve, S., Pereira, A., Perez, T., Pham-Thi, N., Pigearias, B., Pin, I., Piskou, K., Pitsios, C., Pitsios, K., Plavec, D., Poethig, D., Pohl, W., Susic, A. P., Popov, T. A., Portejoie, F., Potter, P., Poulsen, L., Prados-Torres, A., Prarros, F., Price, D., Prokopakis, E., Puy, R., Rabe, K., Raciborski, F., Ramos, J., Recto, M. T., Reda, S. M., Regateiro, F., Reider, N., Reitsma, S., Repka-Ramirez, S., Rimmer, J., Yeverino, D. R., Rizzo, J. A., Robalo-Cordeiro, C., Roberts, G., Roche, N., Gonzalez, M. R., Zagal, E. R., Rolland, C., Roller-Wirns-berger, R., Rodriguez, M. R., Romano, A., Rombaux, P., Romualdez, J., Rosado-Pinto, J., Rosario, N., Rosenwasser, L., Rottem, M., Rouadi, P., Rovina, N., Sinur, I. R., Ruiz, M., Segura, L. T. R., Ryan, D., Sagara, H., Sakai, D., Sakurai, D., Saleh, W., Salimaki, J., Salina, H., Samitas, K. -N., Coronel, M. G. S., Sanchez-Borges, M., Sanchez-Lopez, J., Sarafoleanu, C., Serpa, F. S., Sastre-Dominguez, J., Scadding, G., Scheire, S., Schmid-Grendelmeier, P., Schuhl, J. F., Schunemann, H., Schvalbova, M., Scichilone, N., Sepulveda, C., Serrano, E., Sheikh, A., Shields, M., Shishkov, V., Siafakas, N., Simeonov, A., Simons, E. F., Sisul, J. C., Sitkauskiene, B., Skrindo, I., Soklic, T., Sole, D., Sooronbaev, T., Soto-Martinez, M., Sova, M., Spertini, F., Spranger, O., Stamataki, S., Stefanaki, L., Stellato, C., Stelmach, R., Sterk, P., Strandberg, T., Stute, P., Subramaniam, A., Ulrik, C. S., Sutherland, M., Sylvestre, S., Syrigou, A., Barata, L. T., Takovska, N., Tan, R., Tan, F., Tan, V., Tang, I. P., Taniguchi, M., Tannert, L., Tattersall, J., Teixeira, M. D. C., Thijs, C., Thomas, M., To, T., Todo-Bom, A. M., Togias, A., Tomazic, P. -V., Toppila-Salmi, S., Toskala, E., Triggiani, M., Triller, N., Triller, K., Tsiligianni, I., Ulmeanu, R., Urbancic, J., Pereira, M. U., Vachova, M., Valdes, F., Valenta, R., Rostan, M. V., Valero, A., Vallianatou, M., Valovirta, E., Eerd, M. V., Ganse, E. V., Hage, M., Vandenplas, O., Vasankari, T., Vassileva, D., Ventura, M. T., Vera-Munoz, C., Vicheva, D., Vichyanond, P., Vidgren, P., Viegi, G., Vogelmeier, C., Hertzen, L. V., Vontetsianos, T., Vourdas, D., Wagenmann, M., Walker, S., Wallace, D., Wang, D. Y., Waserman, S., Wickman, M., Williams, S., Williams, D., Wilson, N., Woo, K., Wright, J., Wroczynski, P., Xepapadaki, P., Yakovliev, P., Yamaguchi, M., Yan, K., Yap, Y. Y., Yawn, B., Yiallouros, P., Yoshihara, S., Young, I., Yusuf, O. B., Zaidi, A., Zaitoun, F., Zar, H., Zernotti, M., Zhang, L., Zhong, N., and Zidarn, M.

Published
2020

42. Study protocol for the assessment of nurses internal contamination by antineoplastic drugs in hospital centres: a cross-sectional multicentre descriptive study

Author

Villa, A., Molimard, M., Bignon, E., Martinez, B., ROUYER, M., Mathoulin-Pelissier, S., Baldi, I., VERDUN-ESQUER, C., Canal-Raffin, M., Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
education, EPICENE, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

INTRODUCTION: Antineoplastic drugs (AD) are potentially carcinogenic and/or reprotoxic molecules. Healthcare professionals are increasingly exposed to these drugs and can be potentially contaminated by them. Internal contamination of professionals is a key concern for occupational physicians in the assessment and management of occupational risks in healthcare settings. Objectives of this study are to report AD internal contamination rate in nursing staff and to identify factors associated with internal contamination. METHODS AND ANALYSIS: This trial will be conducted in two French hospital centres: University Hospital of Bordeaux and IUCT-Oncopole of Toulouse. The target population is nurses practicing in one of the fifteen selected care departments where at least one of the five studied AD is handled (5-fluorouracil, cyclophosphamide, doxorubicin, ifosfamide, methotrexate). The trial will be conducted with the following steps: (1) development of analytical methods to quantify AD urine biomarkers, (2) study of the workplace and organization around AD in each care department (transport and handling, professional practices, personal and collective protection equipments available) (3) development of a self-questionnaire detailing professional activities during the day of inclusion, (4) nurses inclusion (urine samples and self-questionnaire collection), (5) urine assays, (6) data analysis. ETHICS AND DISSEMINATION: The study protocol has been approved by the French Advisory Committee on the Treatment of Information in Health Research (CCTIRS) and by the French Data Protection Authority (CNIL). Following the opinion of the Regional Committee for the Protection of Persons, this study is outside the scope of the provisions governing biomedical research and routine care (n degrees 2014/87). The results will be submitted to peer-reviewed journals and reported at suitable national and international meetings. TRIAL REGISTRATION NUMBER: NCT03137641.

Published
2019

45. Identification et analyse des phénotypes des patients BPCO: cohorte PALOMB

Author

Ouaalaya, E.H., primary, El Benna, A., additional, Zysman, M., additional, Berteaud, É., additional, Falque, L., additional, Nguyen, L., additional, Dupis, J.M., additional, Sabatini, M., additional, Bernady, A., additional, Ozier, A., additional, Nocent-Ejnaini, C., additional, Roy, C., additional, Le Guillou, F., additional, Monge, E., additional, Aliati, M., additional, Prudhomme, A., additional, Petrov, L., additional, Quinquenel, M.L., additional, Staali, M., additional, Pilard, F., additional, Sapène, M., additional, Casteigt, J., additional, Moinard, J., additional, Daoudi, Y., additional, Iglesias, E., additional, Blanchard, É., additional, Macey, J., additional, Veillon, R., additional, Demant, X., additional, Bon, C., additional, Grassion, L., additional, Molimard, M., additional, and Raherison-Semjen, C., additional

Published
2021
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48. Use of the Foreign Studies: Transposition of the Results, Prediction of the Therapeutic Effects in the French Population, Modelling of the Public Health Interest

Author

Abenhaïm, L., Ambrosi, P., Bardou, M., Boissel, J-P., Brun, C., Castaigne, A., Chassany, O., de Bels, F., de Sahb Berkovitch, R., El Hasnaoui, A., Fagagni, F., Fourrier-Reglat, A., Gastaldi-Meninger, C., Goehrs, J.-M., Gueffier, F., Hotton, J.-M., Ichou, F., Lechat, P., Maillère, P., Meyer, F., Micallef, J., Molimard, M., Moreau-Defarges, T., Perillat, A., Pigeon, M., Poitrinal, P., Rey-Quino, C., Ricordeau, P., Ropers, J., Massol, Jacques, Zylberman, Myriam, and Goehrs, Jean-Marie

Published
2006
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49. Utilisation des études étrangères : transposition des résultats, prédiction des effets thérapeutiques en population française, modélisation de l’Intérêt de Santé Publique

Author

Abenhaïm, L., Ambrosi, P., Bardou, M., Boissel, J-P., Brun, C., Castaigne, A., Chassany, O., de Bels, F., de Sahb-Berkovitch, R., El-Hasnaoui, A., Fagagni, F., Fourrier-Reglat, A., Gastaldi-Meninger, C., Goehrs, J.-M., Gueffier, F., Hotton, J.-M., Ichou, F., Lechat, P., Maillère, P., Meyer, F., Micallef, J., Molimard, M., Moreau-Defarges, T., Perillat, A., Pigeon, M., Poitrinal, P., Rey-Quino, C., Ricordeau, P., Ropers, J., Massol, Jacques, Zylberman, Myriam, and Goehrs, Jean-Marie

Published
2006
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