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4. Robot-assisted Versus Open Radical Cystectomy in Bladder Cancer: An Economic Evaluation Alongside a Multicentre Comparative Effectiveness Study

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Helder, Sip, Venderbosch, Guus, Calsbeek, Hilly, Wijburg, Carl J., Witjes, J. Alfred, Onna, Ilze E.W.van, Barten, Evert J., Koldewijn, Evert L., Boormans, Joost L., Wijsman, Bart P., Nooter, Ronald I., Zwaan, Peter J., Slaa, Ed te, Meer, Saskia van der, Klaver, Sjoerd O., Fossion, Laurent M.C.L., Bos, Siebe D., Melick, Harm H.E.van, Leliveld, Anna M., Meijer, Richard P., Vis, André N., Molijn, Gerard J., Berendsen, Chris L., Oddens, Jorg R., Michels, Charlotte T.J., Hannink, Gerjon, Rovers, Maroeska M., and Grutters, Janneke P.C.

Published
2022
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5. Cherenkov Telescope Array Contributions to the 35th International Cosmic Ray Conference (ICRC2017)

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Acero, F., Acharya, B. S., Portella, V. Acín, Adams, C., Agudo, I., Aharonian, F., Samarai, I. Al, Alberdi, A., Alcubierre, M., Alfaro, R., Alfaro, J., Alispach, C., Aloisio, R., Batista, R. Alves, Amans, J. -P., Amato, E., Ambrogi, L., Ambrosi, G., Ambrosio, M., Anderson, J., Anduze, M., Angüner, E. O., Antolini, E., Antonelli, L. A., Antonuccio, V., Antoranz, P., Aramo, C., Araya, M., Arcaro, C., Armstrong, T., Arqueros, F., Arrabito, L., Arrieta, M., Asano, K., Asano, A., Ashley, M., Aubert, P., Singh, C. B., Babic, A., Backes, M., Bajtlik, S., Balazs, C., Balbo, M., Ballester, O., Ballet, J., Ballo, L., Balzer, A., Bamba, A., Bandiera, R., Barai, P., Barbier, C., Barcelo, M., Barkov, M., de Almeida, U. Barres, Barrio, J. A., Bastieri, D., Bauer, C., Becciani, U., Becherini, Y., Tjus, J. Becker, Bednarek, W., Belfiore, A., Benbow, W., Benito, M., Berge, D., Bernardini, E., Bernardini, M. G., Bernardos, M., Bernhard, S., Bernlöhr, K., Salucci, C. Bertinelli, Bertucci, B., Besel, M. -A., Beshley, V., Bettane, J., Bhatt, N., Bhattacharyya, W., Bhattachryya, S., Biasuzzi, B., Bicknell, G., Bigongiari, C., Biland, A., Bilinsky, A., Bird, R., Bissaldi, E., Biteau, J., Bitossi, M., Blanch, O., Blasi, P., Blazek, J., Boccato, C., Bockermann, C., Boehm, C., Bohacova, M., Boisson, C., Bolmont, J., Bonanno, G., Bonardi, A., Bonavolontà, C., Bonnoli, G., Borkowski, J., Bose, R., Bosnjak, Z., Böttcher, M., Boutonnet, C., Bouyjou, F., Bowman, L., Bozhilov, V., Braiding, C., Brau-Nogué, S., Bregeon, J., Briggs, M., Brill, A., Brisken, W., Bristow, D., Britto, R., Brocato, E., Brown, A. M., Brown, S., Brügge, K., Brun, P., Brun, F., Brunetti, L., Brunetti, G., Bruno, P., Bryan, M., Buckley, J., Bugaev, V., Bühler, R., Bulgarelli, A., Bulik, T., Burton, M., Burtovoi, A., Busetto, G., Buson, S., Buss, J., Byrum, K., Caccianiga, A., Cameron, R., Canelli, F., Canestrari, R., Capalbi, M., Capasso, M., Capitanio, F., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Cárdenas, V., Cardenzana, J., Cardillo, M., Carlile, C., Caroff, S., Carosi, R., Carosi, A., Carquín, E., Carr, J., Casandjian, J. -M., Casanova, S., Cascone, E., Castro-Tirado, A. J., Mora, J. Castroviejo, Catalani, F., Catalano, O., Cauz, D., Silva, C. Celestino, Celli, S., Cerruti, M., Chabanne, E., Chadwick, P., Chakraborty, N., Champion, C., Chatterjee, A., Chaty, S., Chaves, R., Chen, A., Chen, X., Cheng, K., Chernyakova, M., Chikawa, M., Chitnis, V. R., Christov, A., Chudoba, J., Cieślar, M., Clark, P., Coco, V., Colafrancesco, S., Colin, P., Colombo, E., Colome, J., Colonges, S., Conforti, V., Connaughton, V., Conrad, J., Contreras, J. L., Cornat, R., Cortina, J., Costa, A., Costantini, H., Cotter, G., Courty, B., Covino, S., Covone, G., Cristofari, P., Criswell, S. J., Crocker, R., Croston, J., Crovari, C., Cuadra, J., Cuevas, O., Cui, X., Cumani, P., Cusumano, G., D'Aì, A., D'Ammando, F., D'Avanzo, P., D'Urso, D., Da Vela, P., Dale, Ø., Dang, V. T., Dangeon, L., Daniel, M., Davids, I., Dawson, B., Dazzi, F., De Angelis, A., De Caprio, V., Anjos, R. de Cássia dos, De Cesare, G., De Franco, A., De Frondat, F., Pino, E. M. de Gouveia Dal, de la Calle, I., De Lisio, C., Lopez, R. de los Reyes, De Lotto, B., De Luca, A., De Lucia, M., Neto, J. R. T. de Mello, de Naurois, M., Wilhelmi, E. de Oña, De Palma, F., De Persio, F., de Souza, V., Decock, J., Deil, C., Deiml, P., Del Santo, M., Delagnes, E., Deleglise, G., Reznicek, M. Delfino, Delgado, C., Mengual, J. Delgado, Della Ceca, R., della Volpe, D., Detournay, M., Devin, J., Di Girolamo, T., Di Giulio, C., Di Pierro, F., Di Venere, L., Diaz, L., Díaz, C., Dib, C., Dickinson, H., Diebold, S., Digel, S., Djannati-Ataï, A., Doert, M., Domínguez, A., Prester, D. Dominis, Donnarumma, I., Dorner, D., Doro, M., Dournaux, J. -L., Downes, T., Drake, G., Drappeau, S., Drass, H., Dravins, D., Drury, L., Dubus, G., Morå, K. Dundas, Durkalec, A., Dwarkadas, V., Ebr, J., Eckner, C., Edy, E., Egberts, K., Einecke, S., Eisch, J., Eisenkolb, F., Ekoume, T. R. N., Eleftheriadis, C., Elsässer, D., Emmanoulopoulos, D., Ernenwein, J. -P., Escarate, P., Eschbach, S., Espinoza, C., Evans, P., Evoli, C., Fairbairn, M., Falceta-Goncalves, D., Falcone, A., Ramazani, V. Fallah, Farakos, K., Farrell, E., Fasola, G., Favre, Y., Fede, E., Fedora, R., Fedorova, E., Fegan, S., Fernandez-Alonso, M., Fernández-Barral, A., Ferrand, G., Ferreira, O., Fesquet, M., Fiandrini, E., Fiasson, A., Filipovic, M., Fink, D., Finley, J. P., Finley, C., Finoguenov, A., Fioretti, V., Fiorini, M., Flores, H., Foffano, L., Föhr, C., Fonseca, M. V., Font, L., Fontaine, G., Fornasa, M., Fortin, P., Fortson, L., Fouque, N., Fraga, B., Franco, F. J., Coromina, L. Freixas, Fruck, C., Fugazza, D., Fujita, Y., Fukami, S., Fukazawa, Y., Fukui, Y., Funk, S., Furniss, A., Füßling, M., Gabici, S., Gadola, A., Gallant, Y., Galloway, D., Gallozzi, S., Garcia, B., Garcia, A., Gil, R. García, López, R. Garcia, Garczarczyk, M., Gardiol, D., Gargano, F., Gargano, C., Garozzo, S., Garrido-Ruiz, M., Gascon, D., Gasparetto, T., Gaté, F., Gaug, M., Gebhardt, B., Gebyehu, M., Geffroy, N., Genolini, B., Ghalumyan, A., Ghedina, A., Ghirlanda, G., Giammaria, P., Gianotti, F., Giebels, B., Giglietto, N., Gika, V., Gimenes, R., Giommi, P., Giordano, F., Giovannini, G., Giro, E., Giroletti, M., Gironnet, J., Giuliani, A., Glicenstein, J. -F., Gnatyk, R., Godinovic, N., Goldoni, P., Gómez, J. L., Gómez-Vargas, G., González, M. M., González, J. M., Gothe, K. S., Gotz, D., Goullon, J., Grabarczyk, T., Graciani, R., Graham, J., Grandi, P., Granot, J., Grasseau, G., Gredig, R., Green, A. J., Greenshaw, T., Grenier, I., Griffiths, S., Grillo, A., Grondin, M. -H., Grube, J., Guarino, V., Guest, B., Gueta, O., Gunji, S., Gyuk, G., Hadasch, D., Hagge, L., Hahn, J., Hahn, A., Hakobyan, H., Hara, S., Hardcastle, M. J., Hassan, T., Haubold, T., Haupt, A., Hayashi, K., Hayashida, M., He, H., Heller, M., Helo, J. C., Henault, F., Henri, G., Hermann, G., Hermel, R., Llorente, J. Herrera, Herrero, A., Hervet, O., Hidaka, N., Hinton, J., Hiroshima, N., Hirotani, K., Hnatyk, B., Hoang, J. K., Hoffmann, D., Hofmann, W., Holder, J., Horan, D., Hörandel, J., Hörbe, M., Horns, D., Horvath, P., Houles, J., Hovatta, T., Hrabovsky, M., Hrupec, D., Huet, J. -M., Hughes, G., Hui, D., Hull, G., Humensky, T. B., Hussein, M., Hütten, M., Iarlori, M., Ikeno, Y., Illa, J. M., Impiombato, D., Inada, T., Ingallinera, A., Inome, Y., Inoue, S., Inoue, T., Inoue, Y., Iocco, F., Ioka, K., Ionica, M., Iori, M., Iriarte, A., Ishio, K., Israel, G. L., Iwamura, Y., Jablonski, C., Jacholkowska, A., Jacquemier, J., Jamrozy, M., Janecek, P., Jankowsky, F., Jankowsky, D., Jansweijer, P., Jarnot, C., Jean, P., Johnson, C. A., Josselin, M., Jung-Richardt, I., Jurysek, J., Kaaret, P., Kachru, P., Kagaya, M., Kakuwa, J., Kalekin, O., Kankanyan, R., Karastergiou, A., Karczewski, M., Karkar, S., Katagiri, H., Kataoka, J., Katarzyński, K., Katz, U., Kawanaka, N., Kaye, L., Kazanas, D., Kelley-Hoskins, N., Khélifi, B., Kieda, D. B., Kihm, T., Kimeswenger, S., Kimura, S., Kisaka, S., Kishida, S., Kissmann, R., Kluźniak, W., Knapen, J., Knapp, J., Knödlseder, J., Koch, B., Kocot, J., Kohri, K., Komin, N., Kong, A., Konno, Y., Kosack, K., Kowal, G., Koyama, S., Kraus, M., Krause, M., Krauß, F., Krennrich, F., Kruger, P., Kubo, H., Kudryavtsev, V., Mezek, G. Kukec, Kumar, S., Kuroda, H., Kushida, J., Kushwaha, P., La Palombara, N., La Parola, V., La Rosa, G., Lahmann, R., Lalik, K., Lamanna, G., Landoni, M., Landriu, D., Landt, H., Lang, R. G., Lapington, J., Laporte, P., Blanc, O. Le, Flour, T. Le, Sidaner, P. Le, Leach, S., Leckngam, A., Lee, S. -H., Lee, W. H., Lees, J. -P., Lefaucheur, J., de Oliveira, M. A. Leigui, Lemoine-Goumard, M., Lenain, J. -P., Leto, G., Lico, R., Limon, M., Lindemann, R., Lindfors, E., Linhoff, L., Lipniacka, A., Lloyd, S., Lohse, T., Lombardi, S., Longo, F., Lopez, M., Lopez-Coto, R., Louge, T., Louis, F., Louys, M., Lucarelli, F., Lucchesi, D., Luque-Escamilla, P. L., Lyard, E., Maccarone, M. C., Maccarone, T., Mach, E., Madejski, G. M., Maier, G., Majczyna, A., Majumdar, P., Makariev, M., Malaguti, G., Malouf, A., Maltezos, S., Malyshev, D., Mandat, D., Maneva, G., Manganaro, M., Mangano, S., Manigot, P., Mannheim, K., Maragos, N., Marano, D., Marcowith, A., Marín, J., Mariotti, M., Marisaldi, M., Markoff, S., Martí, J., Martin, J. -M., Martin, P., Martin, L., Martínez, M., Martínez, G., Martínez, O., Marx, R., Masetti, N., Massimino, P., Mastichiadis, A., Mastropietro, M., Masuda, S., Matsumoto, H., Matthews, N., Mattiazzo, S., Maurin, G., Maxted, N., Mayer, M., Mazin, D., Mazziotta, M. N., Comb, L. Mc, McHardy, I., Medina, C., Melandri, A., Melioli, C., Melkumyan, D., Mereghetti, S., Meunier, J. -L., Meures, T., Meyer, M., Micanovic, S., Michael, T., Michałowski, J., Mievre, I., Miller, J., Minaya, I. A., Mineo, T., Mirabel, F., Miranda, J. M., Mirzoyan, R., Mitchell, A., Mizuno, T., Moderski, R., Mohammed, M., Mohrmann, L., Molijn, C., Molinari, E., Moncada, R., Montaruli, T., Monteiro, I., Mooney, D., Moore, P., Moralejo, A., Morcuende-Parrilla, D., Moretti, E., Mori, K., Morlino, G., Morris, P., Morselli, A., Moscato, F., Motohashi, D., Moulin, E., Mueller, S., Mukherjee, R., Munar, P., Mundell, C., Mundet, J., Murach, T., Muraishi, H., Murase, K., Murphy, A., Nagai, A., Nagar, N., Nagataki, S., Nagayoshi, T., Nagesh, B. K., Naito, T., Nakajima, D., Nakamori, T., Nakamura, Y., Nakayama, K., Naumann, D., Nayman, P., Neise, D., Nellen, L., Nemmen, R., Neronov, A., Neyroud, N., Nguyen, T., Nguyen, T. T., Trung, T. Nguyen, Nicastro, L., Nicolau-Kukliński, J., Niemiec, J., Nieto, D., Nievas-Rosillo, M., Nikołajuk, M., Nishijima, K., Nishikawa, K. -I., Nishiyama, G., Noda, K., Nogues, L., Nolan, S., Nosek, D., Nöthe, M., Novosyadlyj, B., Nozaki, S., Nunio, F., O'Brien, P., Oakes, L., Ocampo, C., Ochoa, J. P., Oger, R., Ohira, Y., Ohishi, M., Ohm, S., Okazaki, N., Okumura, A., Olive, J. -F., Ong, R. A., Orienti, M., Orito, R., Orlati, A., Osborne, J. P., Ostrowski, M., Otte, N., Ou, Z., Ovcharov, E., Oya, I., Ozieblo, A., Padovani, M., Paiano, S., Paizis, A., Palacio, J., Palatiello, M., Palatka, M., Pallotta, J., Panazol, J. -L., Paneque, D., Panter, M., Paoletti, R., Paolillo, M., Papitto, A., Paravac, A., Paredes, J. M., Pareschi, G., Parsons, R. D., Paśko, P., Pavy, S., Pe'er, A., Pech, M., Pedaletti, G., Del Campo, P. Peñil, Perez, A., Pérez-Torres, M. A., Perri, L., Perri, M., Persic, M., Petrashyk, A., Petrera, S., Petrucci, P. -O., Petruk, O., Peyaud, B., Pfeifer, M., Piano, G., Piel, Q., Pieloth, D., Pintore, F., García, C. Pio, Pisarski, A., Pita, S., Pizarro, L., Platos, Ł., Pohl, M., Poireau, V., Pollo, A., Porthault, J., Poutanen, J., Pozo, D., Prandini, E., Prasit, P., Prast, J., Pressard, K., Principe, G., Prokhorov, D., Prokoph, H., Prouza, M., Pruteanu, G., Pueschel, E., Pühlhofer, G., Puljak, I., Punch, M., Pürckhauer, S., Queiroz, F., Quinn, J., Quirrenbach, A., Rafighi, I., Rainò, S., Rajda, P. J., Rando, R., Rannot, R. C., Razzaque, S., Reichardt, I., Reimer, O., Reimer, A., Reisenegger, A., Renaud, M., Reposeur, T., Reville, B., Rezaeian, A. H., Rhode, W., Ribeiro, D., Ribó, M., Richer, M. G., Richtler, T., Rico, J., Rieger, F., Riquelme, M., Ristori, P. R., Rivoire, S., Rizi, V., Rodriguez, J., Fernandez, G. Rodriguez, Vázquez, J. J. Rodríguez, Rojas, G., Romano, P., Romeo, G., Roncadelli, M., Rosado, J., Rosen, S., Lees, S. Rosier, Rousselle, J., Rovero, A. C., Rowell, G., Rudak, B., Rugliancich, A., del Mazo, J. E. Ruíz, Rujopakarn, W., Rulten, C., Russo, F., Saavedra, O., Sabatini, S., Sacco, B., Sadeh, I., Hatlen, E. Sæther, Safi-Harb, S., Sahakian, V., Sailer, S., Saito, T., Sakaki, N., Sakurai, S., Salek, D., Greus, F. Salesa, Salina, G., Sanchez, D., Sánchez-Conde, M., Sandaker, H., Sandoval, A., Sangiorgi, P., Sanguillon, M., Sano, H., Santander, M., Santangelo, A., Santos, E. M., Sanuy, A., Sapozhnikov, L., Sarkar, S., Satalecka, K., Sato, Y., Saturni, F. G., Savalle, R., Sawada, M., Schanne, S., Schioppa, E. J., Schlenstedt, S., Schmidt, T., Schmoll, J., Schneider, M., Schoorlemmer, H., Schovanek, P., Schulz, A., Schussler, F., Schwanke, U., Schwarz, J., Schweizer, T., Schwemmer, S., Sciacca, E., Scuderi, S., Seglar-Arroyo, M., Segreto, A., Seitenzahl, I., Semikoz, D., Sergijenko, O., Serre, N., Servillat, M., Seweryn, K., Shah, K., Shalchi, A., Sharma, M., Shellard, R. C., Shilon, I., Sidoli, L., Sidz, M., Siejkowski, H., Silk, J., Sillanpää, A., Simone, D., Singh, B. B., Sironi, G., Sitarek, J., Sizun, P., Sliusar, V., Slowikowska, A., Smith, A., Sobczyńska, D., Sokolenko, A., Sol, H., Sottile, G., Springer, W., Stahl, O., Stamerra, A., Stanič, S., Starling, R., Staszak, D., Stawarz, Ł., Steenkamp, R., Stefanik, S., Stegmann, C., Steiner, S., Stella, C., Stephan, M., Sternberger, R., Sterzel, M., Stevenson, B., Stodulska, M., Stodulski, M., Stolarczyk, T., Stratta, G., Straumann, U., Stuik, R., Suchenek, M., Suomijarvi, T., Supanitsky, A. D., Suric, T., Sushch, I., Sutcliffe, P., Sykes, J., Szanecki, M., Szepieniec, T., Tagliaferri, G., Tajima, H., Takahashi, K., Takahashi, H., Takahashi, M., Takalo, L., Takami, S., Takata, J., Takeda, J., Tam, T., Tanaka, M., Tanaka, T., Tanaka, Y., Tanaka, S., Tanci, C., Tavani, M., Tavecchio, F., Tavernet, J. -P., Tayabaly, K., Tejedor, L. A., Temme, F., Temnikov, P., Terada, Y., Terrazas, J. C., Terrier, R., Terront, D., Terzic, T., Tescaro, D., Teshima, M., Testa, V., Thoudam, S., Tian, W., Tibaldo, L., Tiengo, A., Tiziani, D., Tluczykont, M., Peixoto, C. J. Todero, Tokanai, F., Tokarz, M., Toma, K., Tomastik, J., Tonachini, A., Tonev, D., Tornikoski, M., Torres, D. F., Torresi, E., Tosti, G., Totani, T., Tothill, N., Toussenel, F., Tovmassian, G., Trakarnsirinont, N., Travnicek, P., Trichard, C., Trifoglio, M., Pujadas, I. Troyano, Tsirou, M., Tsujimoto, S., Tsuru, T., Uchiyama, Y., Umana, G., Uslenghi, M., Vagelli, V., Vagnetti, F., Valentino, M., Vallania, P., Valore, L., Berg, A. M. Van den, van Driel, W., van Eldik, C., van Soelen, B., Vandenbroucke, J., Vanderwalt, J., Varner, G. S., Vasileiadis, G., Vassiliev, V., Vázquez, J. R., Acosta, M. Vázquez, Vecchi, M., Vega, A., Veitch, P., Venault, P., Venter, C., Vercellone, S., Veres, P., Vergani, S., Verzi, V., Vettolani, G. P., Veyssiere, C., Viana, A., Vicha, J., Vigorito, C., Villanueva, J., Vincent, P., Vink, J., Visconti, F., Vittorini, V., Voelk, H., Voisin, V., Vollhardt, A., Vorobiov, S., Vovk, I., Vrastil, M., Vuillaume, T., Wagner, S. J., Wagner, R., Wagner, P., Wakely, S. P., Walstra, T., Walter, R., Ward, M., Ward, J. E., Warren, D., Watson, J. J., Webb, N., Wegner, P., Weiner, O., Weinstein, A., Weniger, C., Werner, F., Wetteskind, H., White, M., White, R., Wierzcholska, A., Wiesand, S., Wijers, R., Wilcox, P., Wilhelm, A., Wilkinson, M., Will, M., Williams, D. A., Winter, M., Wojcik, P., Wolf, D., Wood, M., Wörnlein, A., Wu, T., Yadav, K. K., Yaguna, C., Yamamoto, T., Yamamoto, H., Yamane, N., Yamazaki, R., Yanagita, S., Yang, L., Yelos, D., Yoshida, T., Yoshida, M., Yoshiike, S., Yoshikoshi, T., Yu, P., Zaborov, D., Zacharias, M., Zaharijas, G., Zajczyk, A., Zampieri, L., Zandanel, F., Zanin, R., Sanchez, R. Zanmar, Zaric, D., Zavrtanik, M., Zavrtanik, D., Zdziarski, A. A., Zech, A., Zechlin, H., Zhdanov, V. I., Ziegler, A., Ziemann, J., Ziętara, K., Zink, A., Ziółkowski, J., Zitelli, V., Zoli, A., and Zorn, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

List of contributions from the Cherenkov Telescope Array Consortium presented at the 35th International Cosmic Ray Conference, July 12-20 2017, Busan, Korea., Comment: Index of Cherenkov Telescope Array conference proceedings at the ICRC2017, Busan, Korea

Published
2017

9. Introduction of primary screening using high-risk HPV DNA detection in the Dutch cervical cancer screening programme: a population-based cohort study

Author

Clare A. Aitken, Heleen M. E. van Agt, Albert G. Siebers, Folkert J. van Kemenade, Hubert G. M. Niesters, Willem J. G. Melchers, Judith E. M. Vedder, Rob Schuurman, Adriaan J. C. van den Brule, Hans C. van der Linden, John W. J. Hinrichs, Anco Molijn, Klaas J. Hoogduin, Bettien M. van Hemel, and Inge M. C. M. de Kok

Subjects
Cervical cancer screening, hrHPV screening, Population-based screening, Cancer screening programmes, Medicine
Abstract

Abstract Background In January 2017, the Dutch cervical cancer screening programme transitioned from cytomorphological to primary high-risk HPV (hrHPV) DNA screening, including the introduction of self-sampling, for women aged between 30 and 60 years. The Netherlands was the first country to switch to hrHPV screening at the national level. We investigated the health impact of this transition by comparing performance indicators from the new hrHPV-based programme with the previous cytology-based programme. Methods We obtained data from the Dutch nationwide network and registry of histo- and cytopathology (PALGA) for 454,573 women eligible for screening in 2017 who participated in the hrHPV-based programme between 1 January 2017 and 30 June 2018 (maximum follow-up of almost 21 months) and for 483,146 women eligible for screening in 2015 who participated in the cytology-based programme between 1 January 2015 and 31 March 2016 (maximum follow-up of 40 months). We compared indicators of participation (participation rate), referral (screen positivity; referral rate) and detection (cervical intraepithelial neoplasia (CIN) detection; number of referrals per detected CIN lesion). Results Participation in the hrHPV-based programme was significantly lower than that in the cytology-based programme (61% vs 64%). Screen positivity and direct referral rates were significantly higher in the hrHPV-based programme (positivity rate: 5% vs 9%; referral rate: 1% vs 3%). CIN2+ detection increased from 11 to 14 per 1000 women screened. Overall, approximately 2.2 times more clinical irrelevant findings (i.e. ≤CIN1) were found in the hrHPV-based programme, compared with approximately 1·3 times more clinically relevant findings (i.e. CIN2+); this difference was mostly due to a national policy change recommending colposcopy, rather than observation, of hrHPV-positive, ASC-US/LSIL results in the hrHPV-based programme. Conclusions This is the first time that comprehensive results of nationwide implementation of hrHPV-based screening have been reported using high-quality data with a long follow-up. We have shown that both benefits and potential harms are higher in one screening round of a well-implemented hrHPV-based screening programme than in an established cytology-based programme. Lower participation in the new hrHPV programme may be due to factors such as invitation policy changes and the phased roll-out of the new programme. Our findings add further to evidence from trials and modelling studies on the effectiveness of hrHPV-based screening.

Published
2019
Full Text
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10. Clinical performance of high-risk HPV testing on self-samples versus clinician samples in routine primary HPV screening in the Netherlands: An observational study

Author

Federica Inturrisi, Clare A. Aitken, Willem J.G. Melchers, Adriaan J.C. van den Brule, Anco Molijn, John W.J. Hinrichs, Hubert G.M. Niesters, Albert G. Siebers, Rob Schuurman, Daniëlle A.M. Heideman, Inge M.C.M. de Kok, Ruud L.M. Bekkers, Folkert J. van Kemenade, and Johannes Berkhof

Subjects
Human papillomavirus (HPV), Cervical intraepithelial neoplasia, CIN3, Self-sampling, Cervical screening, Clinical accuracy, Public aspects of medicine, RA1-1270
Abstract

Background: High-risk human papillomavirus (hrHPV) testing on self-collected samples has potential as a primary screening tool in cervical screening, but real-world evidence on its accuracy in hrHPV-based screening programmes is lacking. Methods: In the Netherlands, women aged 30–60 years invited for cervical screening can choose between sampling at the clinician's office (Cervex Brush) or self-sampling at home (Evalyn Brush). HrHPV testing is performed using Roche Cobas 4800. We collected screening test results between January 2017 and March 2018 and histological follow-up until August 2019. The main outcome measures were mean cycle threshold (Ct) value, cervical intraepithelial neoplasia (CIN) grade 3 or cancer (CIN3+) and CIN grade 2 or worse (CIN2+). Findings: 30,808 women had a self-collected and 456,207 had a clinician-collected sample. In hrHPV-positive women with adequate cytology, Ct values were higher for self-collection than clinician-collection with a mean Ct difference of 1·25 (95% CI 0·98–1·52) in women without CIN2+, 2·73 (1·75–3·72) in CIN2 and 3·59 (3·03–4·15) in CIN3+. The relative sensitivity for detecting CIN3+ was 0·94 (0·90–0·97) for self-collection versus clinician-collection and the relative specificity was 1·02 (1·02–1·02). Interpretation: The clinical accuracy of hrHPV testing on a self-collected sample for detection of CIN3+ is high and supports its use as a primary screening test for all invited women. Because of the slightly lower sensitivity of hrHPV testing on a self-collected compared to a clinician-collected sample, an evaluation of the workflow procedure to optimise clinical performance seems warranted. Funding: National Institute for Public Health and the Environment (the Netherlands) and the European Commission.

Published
2021
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17. Sociodemographic Characteristics and Screening Outcomes of Women Preferring Self-Sampling in the Dutch Cervical Cancer Screening Programme

Author

Clare A. Aitken, Federica Inturrisi, Sylvia Kaljouw, Daan Nieboer, Albert G. Siebers, Willem J.G. Melchers, Adriaan J.C. van den Brule, Anco Molijn, John W.J. Hinrichs, Hubert G.M. Niesters, Folkert J. van Kemenade, Johannes Berkhof, Inge M.C.M. de Kok, Epidemiology and Data Science, APH - Methodology, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, Pathology, and Public Health

Subjects
All institutes and research themes of the Radboud University Medical Center, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], SDG 3 - Good Health and Well-being, Oncology, Epidemiology
Abstract

Background: In the Netherlands, lower high-risk human papillomavirus (hrHPV) positivity but higher cervical intraepithelial neoplasia (CIN) 2+ detection were found in self-collected compared with clinician-collected samples. To investigate the possible reason for these differences, we compared sociodemographic and screening characteristics of women and related these to screening outcomes. Methods: We extracted data from PALGA on all primary hrHPV screens and associated follow-up tests for 857,866 screened women, invited in 2017 and 2018. We linked these data with sociodemographic data from Statistics Netherlands. Logistic regression was performed for hrHPV positivity and CIN 2+/3+ detection. Results: Out of the 857,866 women, 6.8% chose to use a self-sampling device. A higher proportion of self-sampling users was ages 30 to 35 years, was not previously screened, was living in a one-person household, or was the breadwinner in the household. After adjustment for these factors self-sampling had lower hrHPV positivity (aOR, 0.65; 95% CI, 0.63–0.68)) as compared with clinician-collected sampling, as well as lower odds of CIN 2+ (aOR, 0.76; 95% CI, 0.70–0.82) and CIN 3+ (aOR, 0.86; 95% CI, 0.78–0.95) detection. Conclusions: It is likely that the observed differences between the two sampling methods are not only related to sociodemographic differences, but related to differences in screening test accuracy and/or background risk. Impact: Self-sampling can be used for targeting underscreened women, as a more convenient screening tool. Further investigation is required to evaluate how to implement self-sampling, when it is used as a primary instrument in routine screening. See related commentary by Arbyn et al., p. 159

Published
2023

21. Introduction of primary screening using high-risk HPV DNA detection in the Dutch cervical cancer screening programme: a population-based cohort study

Author

Aitken, Clare A., van Agt, Heleen M. E., Siebers, Albert G., van Kemenade, Folkert J., Niesters, Hubert G. M., Melchers, Willem J. G., Vedder, Judith E. M., Schuurman, Rob, van den Brule, Adriaan J. C., van der Linden, Hans C., Hinrichs, John W. J., Molijn, Anco, Hoogduin, Klaas J., van Hemel, Bettien M., and de Kok, Inge M. C. M.

Published
2019
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24. On the Value of Sentinel-1 InSAR Coherence Time-Series for Vegetation Classification

Author

Tina Nikaein, Lorenzo Iannini, Ramses A. Molijn, and Paco Lopez-Dekker

Subjects
InSAR coherence, time-series, Sentinel-1, land cover mapping, vegetation classification, Science
Abstract

Synthetic aperture radar (SAR) acquisitions are mainly deemed suitable for mapping dynamic land-cover and land-use scenarios due to their timeliness and reliability. This particularly applies to Sentinel-1 imagery. Nevertheless, the accurate mapping of regions characterized by a mixture of crops and grasses can still represent a challenge. Radar time-series have to date mainly been exploited through backscatter intensities, whereas only fewer contributions have focused on analyzing the potential of interferometric information, intuitively enhanced by the short revisit. In this paper, we evaluate, as primary objective, the added value of short-temporal baseline coherences over a complex agricultural area in the São Paulo state, cultivated with heterogeneously (asynchronously) managed annual crops, grasses for pasture and sugarcane plantations. We also investigated the sensitivity of the radar information to the classification methods as well as to the data preparation and sampling practices. Two supervised machine learning methods—namely support vector machine (SVM) and random forest (RF)—were applied to the Sentinel-1 time-series at the pixel and field levels. The results highlight that an improvement of 10 percentage points (p.p.) in the classification accuracy can be achieved by using the coherence in addition to the backscatter intensity and by combining co-polarized (VV) and cross-polarized (VH) information. It is shown that the largest contribution in class discrimination is brought during winter, when dry vegetation and bare soils can be expected. One of the added values of coherence was indeed identified in the enhanced sensitivity to harvest events in a small but significant number of cases.

Published
2021
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25. Evaluation of DNA methylation biomarkers ASCL1 and LHX8 on HPV-positive self-collected samples from primary HPV-based screening.

Author

Verhoef, L., Bleeker, M.C.G., Polman, N., Steenbergen, R.D.M., Ebisch, R.M.F., Melchers, W.J.G., Bekkers, R.L.M., Molijn, A.C., Quint, W.G., Kemenade, F. van, Meijer, C.J.L.M., Berkhof, J., Heideman, D.A.M., Verhoef, L., Bleeker, M.C.G., Polman, N., Steenbergen, R.D.M., Ebisch, R.M.F., Melchers, W.J.G., Bekkers, R.L.M., Molijn, A.C., Quint, W.G., Kemenade, F. van, Meijer, C.J.L.M., Berkhof, J., and Heideman, D.A.M.

Abstract

01 juli 2023, Contains fulltext : 294344.pdf (Publisher’s version ) (Open Access), BACKGROUND: Host-cell DNA methylation analysis can be used to triage women with high-risk human papillomavirus (HPV)-positive self-collected cervicovaginal samples, but current data are restricted to under-/never-screened women and referral populations. This study evaluated triage performance in women who were offered primary HPV self-sampling for cervical cancer screening. METHODS: Self-collected samples from 593 HPV-positive women who participated in a primary HPV self-sampling trial (IMPROVE study; NTR5078), were tested for the DNA methylation markers ASCL1 and LHX8 using quantitative multiplex methylation-specific PCR (qMSP). The diagnostic performance for CIN3 and cervical cancer (CIN3 + ) was evaluated and compared with that of paired HPV-positive clinician-collected cervical samples. RESULTS: Significantly higher methylation levels were found in HPV-positive self-collected samples of women with CIN3 + than control women with no evidence of disease (P values <0.0001). The marker panel ASCL1/LHX8 yielded a sensitivity for CIN3 + detection of 73.3% (63/86; 95% CI 63.9-82.6%), with a corresponding specificity of 61.1% (310/507; 95% CI 56.9-65.4%). The relative sensitivity for detecting CIN3+ was 0.95 (95% CI 0.82-1.10) for self-collection versus clinician-collection, and the relative specificity was 0.82 (95% CI 0.75-0.90). CONCLUSIONS: The ASCL1/LHX8 methylation marker panel constitutes a feasible direct triage method for the detection of CIN3 + in HPV-positive women participating in routine screening by self-sampling.

Published
2023

27. Sociodemographic Characteristics and Screening Outcomes of Women Preferring Self-Sampling in the Dutch Cervical Cancer Screening Programme:A Population-Based Study

Author

Aitken, Clare A., Inturrisi, Federica, Kaljouw, Sylvia, Nieboer, Daan, Siebers, Albert G., Melchers, Willem J.G., van den Brule, Adriaan J.C., Molijn, Anco, Hinrichs, John W.J., Niesters, Hubert G.M., van Kemenade, Folkert J., Berkhof, Johannes, de Kok, Inge M.C.M., Aitken, Clare A., Inturrisi, Federica, Kaljouw, Sylvia, Nieboer, Daan, Siebers, Albert G., Melchers, Willem J.G., van den Brule, Adriaan J.C., Molijn, Anco, Hinrichs, John W.J., Niesters, Hubert G.M., van Kemenade, Folkert J., Berkhof, Johannes, and de Kok, Inge M.C.M.

Abstract

BACKGROUND: In the Netherlands, lower high-risk human papillomavirus (hrHPV) positivity but higher cervical intraepithelial neoplasia (CIN) 2+ detection were found in self-collected compared with clinician-collected samples. To investigate the possible reason for these differences, we compared sociodemographic and screening characteristics of women and related these to screening outcomes. METHODS: We extracted data from PALGA on all primary hrHPV screens and associated follow-up tests for 857,866 screened women, invited in 2017 and 2018. We linked these data with sociodemographic data from Statistics Netherlands. Logistic regression was performed for hrHPV positivity and CIN 2+/3+ detection. RESULTS: Out of the 857,866 women, 6.8% chose to use a self-sampling device. A higher proportion of self-sampling users was ages 30 to 35 years, was not previously screened, was living in a one-person household, or was the breadwinner in the household. After adjustment for these factors self-sampling had lower hrHPV positivity (aOR, 0.65; 95% CI, 0.63-0.68)) as compared with clinician-collected sampling, as well as lower odds of CIN 2+ (aOR, 0.76; 95% CI, 0.70-0.82) and CIN 3+ (aOR, 0.86; 95% CI, 0.78-0.95) detection. CONCLUSIONS: It is likely that the observed differences between the two sampling methods are not only related to sociodemographic differences, but related to differences in screening test accuracy and/or background risk. IMPACT: Self-sampling can be used for targeting underscreened women, as a more convenient screening tool. Further investigation is required to evaluate how to implement self-sampling, when it is used as a primary instrument in routine screening. See related commentary by Arbyn et al., p. 159.

Published
2023

28. Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted vaccine in women older than 25 years: 7-year follow-up of the phase 3, double-blind, randomised controlled VIVIANE study

Author

Wheeler, Cosette M, Skinner, S Rachel, Del Rosario-Raymundo, M Rowena, Garland, Suzanne M, Chatterjee, Archana, Lazcano-Ponce, Eduardo, Salmerón, Jorge, McNeil, Shelly, Stapleton, Jack T, Bouchard, Céline, Martens, Mark G, Money, Deborah M, Quek, Swee Chong, Romanowski, Barbara, Vallejos, Carlos S, ter Harmsel, Bram, Prilepskaya, Vera, Fong, Kah Leng, Kitchener, Henry, Minkina, Galina, Lim, Yong Kuei Timothy, Stoney, Tanya, Chakhtoura, Nahida, Cruickshank, Margaret E, Savicheva, Alevtina, da Silva, Daniel Pereira, Ferguson, Murdo, Molijn, Anco C, Quint, Wim G V, Hardt, Karin, Descamps, Dominique, Suryakiran, Pemmaraju V, Karkada, Naveen, Geeraerts, Brecht, Dubin, Gary, and Struyf, Frank

Published
2016
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32. Barriers to Active Travel: Among Primary School-Aged Children in Wellington

Author

Zara Molijn

Subjects
General Medicine
Abstract

Active school travel (walking, biking, scootering or skating to and from school) is declining in Wellington. This is concerning becauseactive forms of transport benefit children’s mental and physical health, as well as producing wider societal benefits such as lessnoise, reduced air pollution, lower congestion and fewer greenhouse gas emissions. This article explores the barriers to active schooltravel among primary school-aged children in Wellington, based on an anonymous online survey of parents. The results indicatethat the main barriers to active school travel are related to safety concerns, family schedule complexities, and the efficiency of othermodes of transport. Possible solutions include a walking school bus programme and more flexible working hours for parents, specifically during school drop-off and pick-up times.

Published
2022

33. Performance of DNA methylation analysis of ASCL1, LHX8, ST6GALNAC5, GHSR, ZIC1 and SST for the triage of HPV-positive women

Author

Lisanne, Verhoef, Maaike C G, Bleeker, Nicole, Polman, Renske D M, Steenbergen, Chris J L M, Meijer, Willem J G, Melchers, Ruud L, Bekkers, Anco C, Molijn, Wim G, Quint, Folkert J, van Kemenade, Johannes, Berkhof, and Daniëlle A M, Heideman

Subjects
Adult, LIM-Homeodomain Proteins, Uterine Cervical Neoplasms, DNA Methylation, Middle Aged, Uterine Cervical Dysplasia, Sialyltransferases, Cohort Studies, Basic Helix-Loop-Helix Transcription Factors, Humans, Female, Triage, Receptors, Ghrelin, Somatostatin, Papillomaviridae, Transcription Factors
Abstract

Methylation of host-cell deoxyribonucleic acid (DNA) has been proposed as a promising biomarker for triage of high-risk (hr) human papillomavirus (HPV) positive women at screening. Our study aims to validate recently identified host-cell DNA methylation markers for triage in an hrHPV-positive cohort derived from primary HPV-based cervical screening in The Netherlands. Methylation markers ASCL1, LHX8, ST6GALNAC5, GHSR, ZIC1 and SST were evaluated relative to the ACTB reference gene by multiplex quantitative methylation-specific PCR (qMSP) in clinician-collected cervical samples (n = 715) from hrHPV-positive women (age 29-60 years), who were enrolled in the Dutch IMPROVE screening trial (NTR5078). Primary clinical end-point was cervical intraepithelial neoplasia grade 3 (CIN3) or cancer (CIN3+). The single-marker and bi-marker methylation classifiers developed for CIN3 detection in a previous series of hrHPV-positive clinician-collected cervical samples were applied. The diagnostic accuracy was visualised using receiver operating characteristic (ROC) curves and assessed through area under the ROC curve (AUC). The performance of the methylation markers to detect CIN3+ was determined using the predefined threshold calibrated at 70% clinical specificity. Individual methylation makers showed good performance for CIN3+ detection, with highest AUC for ASCL1 (0.844) and LHX8 (0.830). Combined as a bi-marker panel with predefined threshold, ASCL1/LHX8 yielded a CIN3+ sensitivity of 76.9% (70/91; 95% CI 68.3-85.6%) at a specificity of 74.5% (465/624; 95% CI 71.1-77.9%). In conclusion, our study shows that the individual host-cell DNA methylation classifiers and the bi-marker panel ASCL1/LHX8 have clinical utility for the detection of CIN3+ in hrHPV-positive women invited for routine screening.

Published
2022

34. Evaluation of DNA methylation biomarkers ASCL1 and LHX8 on HPV-positive self-collected samples from primary HPV-based screening

Author

Lisanne Verhoef, Maaike C. G. Bleeker, Nicole Polman, Renske D. M. Steenbergen, Renée M. F. Ebisch, Willem J. G. Melchers, Ruud L. M. Bekkers, Anco C. Molijn, Wim G. Quint, Folkert van Kemenade, Chris J. L. M. Meijer, Johannes Berkhof, Daniëlle A. M. Heideman, Pathology, AII - Cancer immunology, CCA - Cancer Treatment and quality of life, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, VU University medical center, Epidemiology and Data Science, and APH - Methodology

Subjects
Cancer Research, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], CERVICAL SCRAPES, HUMAN-PAPILLOMAVIRUS, TRIAGE, (PRE)CANCER, EFFICACY, CANCER, PREVENTION, SPECIMENS, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], CYTOLOGY, All institutes and research themes of the Radboud University Medical Center, Oncology, SDG 3 - Good Health and Well-being, CONCORDANCE
Abstract

Background Host-cell DNA methylation analysis can be used to triage women with high-risk human papillomavirus (HPV)-positive self-collected cervicovaginal samples, but current data are restricted to under-/never-screened women and referral populations. This study evaluated triage performance in women who were offered primary HPV self-sampling for cervical cancer screening. Methods Self-collected samples from 593 HPV-positive women who participated in a primary HPV self-sampling trial (IMPROVE study; NTR5078), were tested for the DNA methylation markers ASCL1 and LHX8 using quantitative multiplex methylation-specific PCR (qMSP). The diagnostic performance for CIN3 and cervical cancer (CIN3 + ) was evaluated and compared with that of paired HPV-positive clinician-collected cervical samples. Results Significantly higher methylation levels were found in HPV-positive self-collected samples of women with CIN3 + than control women with no evidence of disease (P values ASCL1/LHX8 yielded a sensitivity for CIN3 + detection of 73.3% (63/86; 95% CI 63.9–82.6%), with a corresponding specificity of 61.1% (310/507; 95% CI 56.9–65.4%). The relative sensitivity for detecting CIN3+ was 0.95 (95% CI 0.82–1.10) for self-collection versus clinician-collection, and the relative specificity was 0.82 (95% CI 0.75–0.90). Conclusions The ASCL1/LHX8 methylation marker panel constitutes a feasible direct triage method for the detection of CIN3 + in HPV-positive women participating in routine screening by self-sampling.

Published
2023

36. Performance of <scp>DNA</scp> methylation analysis of <scp>ASCL1</scp> , <scp>LHX8</scp> , <scp>ST6GALNAC5</scp> , <scp>GHSR</scp> , <scp>ZIC1</scp> and <scp> SST </scp> for the triage of <scp>HPV</scp> ‐positive women: Results from a Dutch primary <scp>HPV</scp> ‐based screening cohort

Author

Renske D.M. Steenbergen, Maaike C G Bleeker, Lisanne Verhoef, Wim Quint, Chris J.L.M. Meijer, Nicole J Polman, Daniëlle A M Heideman, Ruud L.M. Bekkers, Folkert J. van Kemenade, Johannes Berkhof, Anco Molijn, and Willem J. G. Melchers

Subjects
Oncology, 0303 health sciences, Cancer Research, medicine.medical_specialty, Cervical screening, Receiver operating characteristic, business.industry, Cancer, Methylation, Cervical intraepithelial neoplasia, medicine.disease, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, DNA methylation, medicine, Biomarker (medicine), business, Genotyping, 030304 developmental biology
Abstract

Methylation of host-cell deoxyribonucleic acid (DNA) has been proposed as a promising biomarker for triage of high-risk (hr) human papillomavirus (HPV) positive women at screening. Our study aims to validate recently identified host-cell DNA methylation markers for triage in an hrHPV-positive cohort derived from primary HPV-based cervical screening in The Netherlands. Methylation markers ASCL1, LHX8, ST6GALNAC5, GHSR, ZIC1 and SST were evaluated relative to the ACTB reference gene by multiplex quantitative methylation-specific PCR (qMSP) in clinician-collected cervical samples (n = 715) from hrHPV-positive women (age 29-60 years), who were enrolled in the Dutch IMPROVE screening trial (NTR5078). Primary clinical end-point was cervical intraepithelial neoplasia grade 3 (CIN3) or cancer (CIN3+). The single-marker and bi-marker methylation classifiers developed for CIN3 detection in a previous series of hrHPV-positive clinician-collected cervical samples were applied. The diagnostic accuracy was visualised using receiver operating characteristic (ROC) curves and assessed through area under the ROC curve (AUC). The performance of the methylation markers to detect CIN3+ was determined using the predefined threshold calibrated at 70% clinical specificity. Individual methylation makers showed good performance for CIN3+ detection, with highest AUC for ASCL1 (0.844) and LHX8 (0.830). Combined as a bi-marker panel with predefined threshold, ASCL1/LHX8 yielded a CIN3+ sensitivity of 76.9% (70/91; 95% CI 68.3-85.6%) at a specificity of 74.5% (465/624; 95% CI 71.1-77.9%). In conclusion, our study shows that the individual host-cell DNA methylation classifiers and the bi-marker panel ASCL1/LHX8 have clinical utility for the detection of CIN3+ in hrHPV-positive women invited for routine screening.

Published
2021

37. Sociodemographic Characteristics and Screening Outcomes of Women Preferring Self-Sampling in the Dutch Cervical Cancer Screening Programme: A Population-Based Study

Author

Aitken, Clare A., primary, Inturrisi, Federica, additional, Kaljouw, Sylvia, additional, Nieboer, Daan, additional, Siebers, Albert G., additional, Melchers, Willem J.G., additional, van den Brule, Adriaan J.C., additional, Molijn, Anco, additional, Hinrichs, John W.J., additional, Niesters, Hubert G.M., additional, van Kemenade, Folkert J., additional, Berkhof, Johannes, additional, and de Kok, Inge M.C.M., additional

Published
2022
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39. Space-Borne Tsunami Warning System

Author

Brouwer, Peter A.I., Visser, Mark, Molijn, Ramses A., Jara Orué, Hermes M., van Marwijk, Bart J.A., Bermon, Tjerk C.K., van der Marel, Hans, and Olla, Phillip, editor

Published
2009
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40. Crop Monitoring Using Sentinel-1 Data: A Case Study from The Netherlands

Author

Saeed Khabbazan, Paul Vermunt, Susan Steele-Dunne, Lexy Ratering Arntz, Caterina Marinetti, Dirk van der Valk, Lorenzo Iannini, Ramses Molijn, Kees Westerdijk, and Corné van der Sande

Subjects
radar, agriculture, SAR, Sentinel-1, crop monitoring, phenology, Science
Abstract

Agriculture is of huge economic significance in The Netherlands where the provision of real-time, reliable information on crop development is essential to support the transition towards precision agriculture. Optical imagery can provide invaluable insights into crop growth and development but is severely hampered by cloud cover. This case study in the Flevopolder illustrates the potential value of Sentinel-1 for monitoring five key crops in The Netherlands, namely sugar beet, potato, maize, wheat and English rye grass. Time series of radar backscatter from the European Space Agency’s Sentinel-1 Mission are analyzed and compared to ground measurements including phenological stage and height. Temporal variations in backscatter data reflect changes in water content and structure associated with phenological development. Emergence and closure dates are estimated from the backscatter time series and validated against a photo archive. Coherence data are compared to Normalized Difference Vegetation Index (NDVI) and ground data, illustrating that the sudden increase in coherence is a useful indicator of harvest. The results presented here demonstrate that Sentinel-1 data have significant potential value to monitor growth and development of key Dutch crops. Furthermore, the guaranteed availability of Sentinel-1 imagery in clouded conditions ensures the reliability of data to meet the monitoring needs of farmers, food producers and regulatory bodies.

Published
2019
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41. Sugarcane Productivity Mapping through C-Band and L-Band SAR and Optical Satellite Imagery

Author

Ramses A. Molijn, Lorenzo Iannini, Jansle Vieira Rocha, and Ramon F. Hanssen

Subjects
sugarcane growth monitoring, SAR and optical remote sensing, precipitation effects, saturation effects, Science
Abstract

Space-based remote sensing imagery can provide a valuable and cost-effective set of observations for mapping crop-productivity differences. The effectiveness of such signals is dependent on several conditions that are related to crop and sensor characteristics. In this paper, we present the dynamic behavior of signals from five Synthetic Aperture Radar (SAR) sensors and optical sensors with growing sugarcane, focusing on saturation effects and the influence of precipitation events. In addition, we analyzed the level of agreement within and between these spaceborne datasets over space and time. As a result, we produced a list of conditions during which the acquisition of satellite imagery is most effective for sugarcane productivity monitoring. For this, we analyzed remote sensing data from two C-band SAR (Sentinel-1 and Radarsat-2), one L-band SAR (ALOS-2), and two optical sensors (Landsat-8 and WorldView-2), in conjunction with detailed ground-reference data acquired over several sugarcane fields in the state of São Paulo, Brazil. We conclude that satellite imagery from L-band SAR and optical sensors is preferred for monitoring sugarcane biomass growth in time and space. Additionally, C-band SAR imagery offers the potential for mapping spatial variations during specific time windows and may be further exploited for its precipitation sensitivity.

Published
2019
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43. Performance of DNA methylation analysis of ASCL1, LHX8, ST6GALNAC5, GHSR, ZIC1 and SST for the triage of HPV-positive women: Results from a Dutch primary HPV-based screening cohort

Author

Verhoef, L., Bleeker, M.C.G., Polman, N., Steenbergen, R.D., Meijer, C., Melchers, W.J.G., Bekkers, R.L.M., Molijn, A.C., Quint, W.G., Kemenade, F.J. van, Berkhof, J., Heideman, D. A. M., Verhoef, L., Bleeker, M.C.G., Polman, N., Steenbergen, R.D., Meijer, C., Melchers, W.J.G., Bekkers, R.L.M., Molijn, A.C., Quint, W.G., Kemenade, F.J. van, Berkhof, J., and Heideman, D. A. M.

Abstract

Item does not contain fulltext, Methylation of host-cell deoxyribonucleic acid (DNA) has been proposed as a promising biomarker for triage of high-risk (hr) human papillomavirus (HPV) positive women at screening. Our study aims to validate recently identified host-cell DNA methylation markers for triage in an hrHPV-positive cohort derived from primary HPV-based cervical screening in The Netherlands. Methylation markers ASCL1, LHX8, ST6GALNAC5, GHSR, ZIC1 and SST were evaluated relative to the ACTB reference gene by multiplex quantitative methylation-specific PCR (qMSP) in clinician-collected cervical samples (n = 715) from hrHPV-positive women (age 29-60 years), who were enrolled in the Dutch IMPROVE screening trial (NTR5078). Primary clinical end-point was cervical intraepithelial neoplasia grade 3 (CIN3) or cancer (CIN3+). The single-marker and bi-marker methylation classifiers developed for CIN3 detection in a previous series of hrHPV-positive clinician-collected cervical samples were applied. The diagnostic accuracy was visualised using receiver operating characteristic (ROC) curves and assessed through area under the ROC curve (AUC). The performance of the methylation markers to detect CIN3+ was determined using the predefined threshold calibrated at 70% clinical specificity. Individual methylation makers showed good performance for CIN3+ detection, with highest AUC for ASCL1 (0.844) and LHX8 (0.830). Combined as a bi-marker panel with predefined threshold, ASCL1/LHX8 yielded a CIN3+ sensitivity of 76.9% (70/91; 95% CI 68.3-85.6%) at a specificity of 74.5% (465/624; 95% CI 71.1-77.9%). In conclusion, our study shows that the individual host-cell DNA methylation classifiers and the bi-marker panel ASCL1/LHX8 have clinical utility for the detection of CIN3+ in hrHPV-positive women invited for routine screening.

Published
2022

44. Performance of DNA methylation analysis of ASCL1, LHX8, ST6GALNAC5, GHSR, ZIC1 and SST for the triage of HPV-positive women:Results from a Dutch primary HPV-based screening cohort

Author

Verhoef, Lisanne, Bleeker, Maaike C.G., Polman, Nicole, Steenbergen, Renske D.M., Meijer, Chris J.L.M., Melchers, Willem J.G., Bekkers, Ruud L., Molijn, Anco C., Quint, Wim G., van Kemenade, Folkert J., Berkhof, Johannes, Heideman, Daniëlle A.M., Verhoef, Lisanne, Bleeker, Maaike C.G., Polman, Nicole, Steenbergen, Renske D.M., Meijer, Chris J.L.M., Melchers, Willem J.G., Bekkers, Ruud L., Molijn, Anco C., Quint, Wim G., van Kemenade, Folkert J., Berkhof, Johannes, and Heideman, Daniëlle A.M.

Abstract

Methylation of host-cell deoxyribonucleic acid (DNA) has been proposed as a promising biomarker for triage of high-risk (hr) human papillomavirus (HPV) positive women at screening. Our study aims to validate recently identified host-cell DNA methylation markers for triage in an hrHPV-positive cohort derived from primary HPV-based cervical screening in The Netherlands. Methylation markers ASCL1, LHX8, ST6GALNAC5, GHSR, ZIC1 and SST were evaluated relative to the ACTB reference gene by multiplex quantitative methylation-specific PCR (qMSP) in clinician-collected cervical samples (n = 715) from hrHPV-positive women (age 29-60 years), who were enrolled in the Dutch IMPROVE screening trial (NTR5078). Primary clinical end-point was cervical intraepithelial neoplasia grade 3 (CIN3) or cancer (CIN3+). The single-marker and bi-marker methylation classifiers developed for CIN3 detection in a previous series of hrHPV-positive clinician-collected cervical samples were applied. The diagnostic accuracy was visualised using receiver operating characteristic (ROC) curves and assessed through area under the ROC curve (AUC). The performance of the methylation markers to detect CIN3+ was determined using the predefined threshold calibrated at 70% clinical specificity. Individual methylation makers showed good performance for CIN3+ detection, with highest AUC for ASCL1 (0.844) and LHX8 (0.830). Combined as a bi-marker panel with predefined threshold, ASCL1/LHX8 yielded a CIN3+ sensitivity of 76.9% (70/91; 95% CI 68.3-85.6%) at a specificity of 74.5% (465/624; 95% CI 71.1-77.9%). In conclusion, our study shows that the individual host-cell DNA methylation classifiers and the bi-marker panel ASCL1/LHX8 have clinical utility for the detection of CIN3+ in hrHPV-positive women invited for routine screening.

Published
2022

45. Robot-assisted Versus Open Radical Cystectomy in Bladder Cancer: An Economic Evaluation Alongside a Multicentre Comparative Effectiveness Study

Author

MS Urologische Oncologie, Cancer, Michels, Charlotte T.J., Wijburg, Carl J., Hannink, Gerjon, Witjes, J. Alfred, Rovers, Maroeska M., Grutters, Janneke P.C., Helder, Sip, Venderbosch, Guus, Calsbeek, Hilly, Onna, Ilze E.W.van, Barten, Evert J., Koldewijn, Evert L., Boormans, Joost L., Wijsman, Bart P., Nooter, Ronald I., Zwaan, Peter J., Slaa, Ed te, Meer, Saskia van der, Klaver, Sjoerd O., Fossion, Laurent M.C.L., Bos, Siebe D., Melick, Harm H.E.van, Leliveld, Anna M., Meijer, Richard P., Vis, André N., Molijn, Gerard J., Berendsen, Chris L., Oddens, Jorg R., MS Urologische Oncologie, Cancer, Michels, Charlotte T.J., Wijburg, Carl J., Hannink, Gerjon, Witjes, J. Alfred, Rovers, Maroeska M., Grutters, Janneke P.C., Helder, Sip, Venderbosch, Guus, Calsbeek, Hilly, Onna, Ilze E.W.van, Barten, Evert J., Koldewijn, Evert L., Boormans, Joost L., Wijsman, Bart P., Nooter, Ronald I., Zwaan, Peter J., Slaa, Ed te, Meer, Saskia van der, Klaver, Sjoerd O., Fossion, Laurent M.C.L., Bos, Siebe D., Melick, Harm H.E.van, Leliveld, Anna M., Meijer, Richard P., Vis, André N., Molijn, Gerard J., Berendsen, Chris L., and Oddens, Jorg R.

Published
2022

46. Robot-assisted Versus Open Radical Cystectomy in Bladder Cancer: An Economic Evaluation Alongside a Multicentre Comparative Effectiveness Study

Author

Michels, Charlotte T.J., primary, Wijburg, Carl J., additional, Hannink, Gerjon, additional, Witjes, J. Alfred, additional, Rovers, Maroeska M., additional, Grutters, Janneke P.C., additional, Helder, Sip, additional, Venderbosch, Guus, additional, Calsbeek, Hilly, additional, Onna, Ilze E.W.van, additional, Barten, Evert J., additional, Koldewijn, Evert L., additional, Boormans, Joost L., additional, Wijsman, Bart P., additional, Nooter, Ronald I., additional, Zwaan, Peter J., additional, Slaa, Ed te, additional, Meer, Saskia van der, additional, Klaver, Sjoerd O., additional, Fossion, Laurent M.C.L., additional, Bos, Siebe D., additional, Melick, Harm H.E.van, additional, Leliveld, Anna M., additional, Meijer, Richard P., additional, Vis, André N., additional, Molijn, Gerard J., additional, Berendsen, Chris L., additional, and Oddens, Jorg R., additional

Published
2022
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47. Human Papillomavirus Type-Distribution in Cervical Cancer in China: The Importance of HPV 16 and 18

Author

Chen, Wen, Zhang, Xun, Molijn, Anco, Jenkins, David, Shi, Ju-Fang, Quint, Wim, Schmidt, Johannes E., Wang, Ping, Liu, Yu-Ling, Li, Lian-Kun, Shi, Hong, Liu, Ji-Hong, Xie, Xing, Niyazi, Mayinuer, Yang, Pei, Wei, Li-Hui, Li, Long-Yu, Li, Jie, Liu, Jin-Feng, Zhou, Qi, Hong, Ying, Li, Li, Li, Qing, Zhou, Hong-Lin, Bian, Mei-Lu, Chen, Jing, Qiao, You-Lin, and Smith, Jennifer S.

Published
2009
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49. Vegetation Characterization through the Use of Precipitation-Affected SAR Signals

Author

Ramses A. Molijn, Lorenzo Iannini, Paco López Dekker, Paulo S.G. Magalhães, and Ramon F. Hanssen

Subjects
SAR signals, precipitation, vegetation classification, soil type, incidence angle, Science
Abstract

Current space-based SAR offers unique opportunities to classify vegetation types and to monitor vegetation growth due to its frequent acquisitions and its sensitivity to vegetation geometry. However, SAR signals also experience frequent temporal fluctuations caused by precipitation events, complicating the mapping and monitoring of vegetation. In this paper, we show that the influence of a priori known precipitation events on the signals can be used advantageously for the classification of vegetation conditions. For this, we exploit the change in Sentinel-1 backscatter response between consecutive acquisitions under varying wetness conditions, which we show is dependent on the state of vegetation. The performance further improves when a priori information on the soil type is taken into account.

Published
2018
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50. Clinical performance of high-risk HPV testing on self-samples versus clinician samples in routine primary HPV screening in the Netherlands: An observational study

Author

Inturrisi, Federica, primary, Aitken, Clare A., additional, Melchers, Willem J.G., additional, van den Brule, Adriaan J.C., additional, Molijn, Anco, additional, Hinrichs, John W.J., additional, Niesters, Hubert G.M., additional, Siebers, Albert G., additional, Schuurman, Rob, additional, Heideman, Daniëlle A.M., additional, de Kok, Inge M.C.M., additional, Bekkers, Ruud L.M., additional, van Kemenade, Folkert J., additional, and Berkhof, Johannes, additional

Published
2021
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