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2. Associations between food portion sizes, insulin resistance, VO2 max and metabolic syndrome in European adolescents: The HELENA study

Author

Coordinator, Moreno, L.A., Core Group members, Gottrand, F., De Henauw, S., González-Gross, M., Gilbert, C., Steering Committee, Kafatos, A., Libersa, C., Castelló, S., Kersting, M., Sjöstrom, M., Molnár, D., Dallongeville, J., Hall, G., Maes, L., Scalfi, L., Project Manager, Meléndez, P., Casajús, J.A., Fleta, J., Rodríguez, G., Tomás, C., Mesana, M.I., Vicente-Rodríguez, G., Villarroya, A., Gil, C.M., Ara, I., Alvira, J.F., Bueno, G., Bueno, O., León, J.F., Garagorri, J.Ma, Labayen, I., Iglesia, I., Bel, S., Gracia Marco, L.A., Mouratidou, T., Santaliestra-Pasías, A., González-Gil, E., De Miguel-Etayo, P., Miguel-Berges, M., Iguacel, I., Rupérez, A., Marcos, A., Wärnberg, J., Nova, E., Gómez, S., Díaz, L.E., Romeo, J., Veses, A., Zapatera, B., Pozo, T., Martínez, D., Beghin, L., Iliescu, C., Von Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Molnar, D., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, M., Nagy, E.ö, Kovács, O., Répasi, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Vardavas, C., Sbokos, M., Protoyeraki, E., Fasoulaki, M., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Castillo, M.J., Gutiérrez, Á., Ortega, F.B., Ruiz, J.R., Artero, E.G., España, V., Jiménez-Pavón, D., Chillón, P., Sánchez-Muñoz, C., Cuenca, M., former INRAN, Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Censi, L., Ciarapica, D., D'Acapito, P., Ferrari, M., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Roccaldo, R., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., De Bourdeaudhuij, I., De Vriendt, T., Matthys, C., Vereecken, C., de Maeyer, M., Ottevaere, C., Huybrechts, I., Widhalm, K., Phillipp, K., Dietrich, S., Kubelka, B., Boriss-Riedl, M., Manios, Y., Grammatikaki, E., Bouloubasi, Z., Cook, T.L., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Hagströmer, M., Wennlöf, A.H., Hallström, L., Patterson, E., Kwak, L., Rizzo, N., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J.E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M.J., Thoma-IRs, S., Allchurch, E., Burgess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., von Fircks, H., Hallberg, M.L., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Pedrero-Chamizo, R., Meléndez, A., Valtueña, J., Albers, U., Benito, P.J., Gómez Lorente, J.J., Cañada, D., Urzanqui, A., Torres, R.M., Navarro, P., Flieh, S.M., Miguel-Berges, M.L., Gonzalez-Gross, M., Gesteiro, E., Abbeddou, S., and González-Gil, E.M.

Published
2022
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5. Implementing a SARS-CoV-2 Early Warning System in Valencia (Spain) and its Correlation with Epidemiological Indicators

Author

P. Perez, R. Seguí López-Peñalver, J.A. Lujan, E. Méndez Belinchón, J. Plaza Molero, and J.F. Maestre Picón

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Purpose: To implement a SARS-CoV-2 wastewater surveillance system in Valencia and study the correlation between SARS-CoV-2 concentration levels and epidemiological indicators. Methods & Materials: The working strategy developed in the municipality of Valencia consisted of monitoring wastewater effluents collected by 790,000 people. The city was divided into 24 different hydraulic sectors. 3,023 samples of untreated wastewater were collected and analysed between May 2020 and May 2021. RNA extraction from sewage material was carried out using the NucleoSpin RNA virus Kit. SARS-CoV-2 RNA detection was performed by RT-qPCR using One-Step PrimeScript™ RT-PCR Kit (Perfect Real Time), targeting the nucleoprotein (N), N1 and N2 fragments, and envelope protein (E) gene. Mengovirus RNA recovery rates were used as quality assurance parameters according to ISO 15216-1:2017. Results: A total of 2,169 samples were positive for SARS-CoV-2 RNA material. SARS-CoV-2 variations were detected throughout the entire study evidencing trends during the first, second and third wave. As the National State of Emergency ended (June 2020), SARS-CoV-2 values began to increase reaching the first and most significant concentration spike of the study (20th-26th of July 2020), with a weekly average aggregate concentration of 34,5M GC/L (an increase of 2 units in the log scale). This translated in the worsening of epidemiological indicators (number of cases, hospitalizations, deaths and cumulative incidence (CI)), which maintained a stable increase until a second spike was detected during an important bank holiday in October (9th-12th), where the concentration changed from 28M GC/L to 345M GC/L in a 3-day period while the city was registering 1,100 new weekly cases and a CI of 200 cases/100,000 residents. Finally, a third wave placed Valencia with the worst historical epidemiological data (6,545 new cases; 1,000 new hospitalizations; CI= 1,318,04 cases/100,000 inhabitants) with a weekly SARS-CoV-2 average aggregate concentration of 967M GC/L, leading health officials to implement new restrictive measures. Conclusion: Wastewater surveillance could be used as a complimentary tool to estimate the presence and prevalence of COVID-19 in communities and can be used for preventive purposes, as an increasing SARS-CoV-2 trend in wastewater could be a signal of the possible re-emergence of the pandemic.

Published
2022
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6. Improving quality of care and clinical outcomes for rectal cancer through clinical audits in a multicentre cancer care organisation

Author

M. G. Torras, E. Canals, C. Muñoz-Montplet, A. Vidal, D. Jurado, A. Eraso, S. Villà, M. Caro, J. Molero, M. Macià, M. Puigdemont, E. González-Muñoz, A. López, F. Guedea, and J. M. Borras

Subjects
Rectal Cancer, Clinical audit, Radiotherapy process, Clinical practice variability, Improvement Quality process, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Introduction Colorectal cancer treatment requires a complex, multidisciplinary approach. Because of the potential variability, monitoring through clinical audits is advisable. This study assesses the effects of a quality improvement action plan in patients with locally advanced rectal cancer and treated with radiotherapy. Methods Comparative, multicentre study in two cohorts of 120 patients each, selected randomly from patients diagnosed with rectal cancer who had initiated radiotherapy with a curative intent. Based on the results from a baseline clinical audit in 2013, a quality improvement action plan was designed and implemented; a second audit in 2017 evaluated its impact. Results Standardised information was present on 77.5% of the magnetic resonance imaging (MRI) staging reports. Treatment strategies were similar in all three study centres. Of the patients whose treatment was interrupted, just 9.7% received a compensation dose. There was an increase in MRI re-staging from 32.5 to 61.5%, and a significant decrease in unreported circumferential resection margins following neoadjuvant therapy (ypCRM), from 34.5 to 5.6% (p

Published
2020
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8. Correlates of ideal cardiovascular health in European adolescents: The HELENA study

Author

Moreno, L.A., Gottrand, F., De Henauw, S., González-Gross, M., Gilbert, C., Kafatos, A., Libersa, C., Sánchez, J., Kersting, M., Sjöstrom, M., Molnár, D., Dallongeville, J., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J.A., Rodríguez, G., Tomás, C., Mesana, M.I., Vicente-Rodríguez, G., Villarroya, A., Gil, C.M., Ara, I., Revenga, J., Lachen, C., Alvira, J.F., Bueno, G., Lázaro, A., Bueno, O., León, J.F., Garagorri, J.M<ce:sup loc='post">a</ce:sup>, Bueno, M., Rey López, J.P., Iglesia, I., Velasco, P., Bel, S., Marcos, A., Wärnberg, J., Nova, E., Gómez-Martinez, S., Díaz, L.E., Romeo, J., Veses, A., Puertollano, M.A., Zapatera, B., Pozo, T., Beghin, L., Iliescu, C., Von Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Molnar, D., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Nagy, E., Kovács, O., Repásy, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Vardavas, C., Sbokos, M., Protoyeraki, E., Fasoulaki, M., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Castillo, M.J., Gutiérrez, Á., Ortega, F.B., Ruiz, J.R., Artero, E.G., España-Romero, V., Jiménez-Pavón, D., Chillón, P., Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Censi, L., Ciarapica, D., D'Acapito, P., Ferrari, M., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., De Bourdeaudhuij, I., De Vriendt, T., Matthys, C., Vereecken, C., de Maeyer, M., Ottevaere, C., Widhalm, K., Phillipp, K., Dietrich, S., Kubelka, B., Boriss-Riedl, M., Manios, Y., Grammatikaki, E., Bouloubasi, Z., Cook, T.L., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Kondaki, K., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Bergman, P., Hagströmer, M., Hallström, L., Hallberg, M., Poortvliet, E., Rizzo, N., Beckman, L., Wennlöf, A.H., Patterson, E., Kwak, L., Cernerud, L., Tillgren, P., Sörensen, S., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J.E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M.J., Castelló, S., Thomas, S., Allchurch, E., Burguess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., von Fircks, H., Hallberg, M.L., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Valtueña, J., Albers, U., Pedrero, R., Meléndez, A., Benito, P.J., Calderón, J., Gómez Lorente, J.J., Cañada, D., Urzanqui, A., Carlos Ortiz, J., Fuentes, F., María Torres, R., Navarro, P., Henriksson, P., Henriksson, H., Labayen, I., Huybrechts, I., and Gracia-Marco, L.

Published
2018
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9. Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study

Author

Moreno, L.A., Gottrand, F., De Henauw, S., González-Gross, M., Gilbert, C., Kafatos, A., Libersa, C., Castelló, S., Kersting, M., Sjöstrom, M., Molnár, D., Dallongeville, J., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J.A., Rodríguez, G., Tomás, C., Mesana, M.I., Vicente-Rodríguez, G., Villarroya, A., Gil, C.M., Ara, I., Alvira, J.F., Bueno, G., Lázaro, A., Bueno, O., León, J.F., Garagorri, J.M<ce:sup loc='post">a</ce:sup>, Bueno, M., Labayen, I., Iglesia, I., Bel Serrat, S., Gracia Marco, L.A., Mouratidou, T., Santaliestra-Pasías, A., González-Gil, E.M., De Miguel-Etayo, P., Julián Almárcegui, C., Miguel-Berges, M., Iguacel, I., Marcos, A., Wärnberg, J., Nova, E., Gómez, S., Díaz, L.E., Romeo, J., Veses, A., Zapatera, B., Pozo, T., Martínez, D., Beghin, L., Iliescu, C., Von Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Molnar, D., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Nagy, E., Kovács, O., Répasi, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Vardavas, C., Sbokos, M., Protoyeraki, E., Fasoulaki, M., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Castillo, M.J., Gutiérrez, Á., Ortega, F.B., Ruiz, J.R., Artero, E.G., España, V., Jiménez-Pavón, D., Chillón, P., Sánchez-Muñoz, C., Cuenca, M., Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Censi, L., Ciarapica, D., D'Acapito, P., Ferrari, M., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Roccaldo, R., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., De Bourdeaudhuij, I., De Vriendt, T., Matthys, C., Vereecken, C., de Maeyer, M., Ottevaere, C., Huybrechts, I., Widhalm, K., Phillipp, K., Dietrich, S., Manios, Y., Grammatikaki, E., Bouloubasi, Z., Cook, T.L., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Hagströmer, M., Wennlöf, A.H., Hallström, L., Patterson, E., Kwak, L., Rizzo, N., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J.E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M.J., Thomas, S., Allchurch, E., Burgess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., von Fircks, H., Hallberg, M.L., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Pedrero-Chamizo, R., Meléndez, A., Valtueña, J., Albers, U., Benito, P.J., Gómez Lorente, J.J., Cañada, D., Urzanqui, A., Torres, R.M., Navarro, P., Cadenas-Sanchez, C., Santabárbara, J., Bueno-Lozano, G., Siani, A., Amaro-Gahete, F., and Rupérez, A.I.

Published
2018
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10. Ideal cardiovascular health and inflammation in European adolescents: The HELENA study

Author

Moreno, L.A., Gottrand, F., De Henauw, S., González-Gross, M., Gilbert, C., Kafatos, A., Libersa, C., Castelló, S., Kersting, M., Sjöstrom, M., Molnár, D., Dallongeville, J., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J.A., Rodríguez, G., Tomás, C., Mesana, M.I., Vicente-Rodríguez, G., Villarroya, A., Gil, C.M., Ara, I., Alvira, J.F., Bueno, G., Lázaro, A., Bueno, O., León, J.F., Garagorri, J.M<ce:sup loc='post">a</ce:sup>, Bueno, M., Labayen, I., Iglesia, I., Bel Serrat, S., Gracia Marco, L.A., Mouratidou, T., Santaliestra-Pasías, A., González-Gil, E.M., De Miguel-Etayo, P., Julián Almárcegui, C., Miguel-Berges, M., Iguacel, I., Marcos, A., Wärnberg, J., Nova, E., Gómez, S., Díaz, L.E., Romeo, J., Veses, A., Zapatera, B., Pozo, T., Martínez, D., Beghin, L., Iliescu, C., Von Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Molnar, D., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Nagy, E.ö, Kovács, O., Répasi, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Vardavas, C., Sbokos, M., Protoyeraki, E., Fasoulaki, M., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Castillo, M.J., Gutiérrez, Á., Ortega, F.B., Ruiz, J.R., Artero, E.G., España, V., Jiménez-Pavón, D., Chillón, P., Sánchez-Muñoz, C., Cuenca, M., Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Censi, L., Ciarapica, D., D'Acapito, P., Ferrari, M., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Roccaldo, R., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., De Bourdeaudhuij, I., De Vriendt, T., Matthys, C., Vereecken, C., de Maeyer, M., Ottevaere, C., Huybrechts, I., Widhalm, K., Phillipp, K., Dietrich, S., Manios, Y., Grammatikaki, E., Bouloubasi, Z., Cook, T.L., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Hagströmer, M., Wennlöf, A.H., Hallström, L., Patterson, E., Kwak, L., Rizzo, N., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J.E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M.J., Thomas, S., Allchurch, E., Burgess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., von Fircks, H., Hallberg, M.L., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Pedrero-Chamizo, R., Meléndez, A., Valtueña, J., Albers, U., Benito, P.J., Gómez Lorente, J.J., Cañada, D., Urzanqui, A., Torres, R.M., Navarro, P., Santabárbara, J., Bel-Serrat, S., de la O, A., Palacios Le Blé, G., Siani, A., Gómez-Martínez, S., and Moreno Aznar, L.A.

Published
2017
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11. Photocatalytic Functionalization of Dihydroquinoxalin‐2‐Ones with Pyrazolones

Author

Jaume Rostoll‐Berenguer, Francisco J. Sierra‐Molero, Gonzalo Blay, José R. Pedro, and Carlos Vila

Subjects
Compostos heterocíclics, Catàlisi, General Chemistry, Química orgànica
Abstract

A visible-light photoredox functionalization of 3,4-dihydro-quinoxalin-2-ones with pyrazolones using an inexpensive organophotoredox catalyst is described. The reaction uses 9,10-phenanthrenedione as photocatalyst, a very simple and cheap photocatalyst, a HP single Blue LED (455 nm) as visible-light source and oxygen from air as terminal oxidant, obtaining the corresponding acetylated pyrazoles with good yields. The reaction can be extended to other nitrogen heterocycles such as 5-aminopyrazoles with good results.

Published
2022
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18. Polyurethane Adhesives with Chemically Debondable Properties via Diels–Alder Bonds

Author

Universidad de Alicante. Departamento de Química Orgánica, Universidad de Alicante. Instituto Universitario de Síntesis Orgánica, Carbonell Blasco, Pilar, Moyano, Alejandra, Hernández Fernández, Carlota, Sierra-Molero, Francisco J., Pastor, Isidro M., Alonso, Diego A., Arán-Aís, Francisca, Orgilés-Calpena, Elena, Universidad de Alicante. Departamento de Química Orgánica, Universidad de Alicante. Instituto Universitario de Síntesis Orgánica, Carbonell Blasco, Pilar, Moyano, Alejandra, Hernández Fernández, Carlota, Sierra-Molero, Francisco J., Pastor, Isidro M., Alonso, Diego A., Arán-Aís, Francisca, and Orgilés-Calpena, Elena

Abstract

Covalent adaptable networks (CANs) represent a pioneering advance in polymer science, offering unprecedented versatility in materials design. Unlike conventional adhesives with irreversible bonds, CAN-based polyurethane adhesives have the unique ability to undergo chemical restructuring through reversible bonds. One of the strategies for incorporating these types of reactions in polyurethanes is by functionalisation with Diels–Alder (DA) adducts. By taking advantage of the reversible nature of the DA chemistry, the adhesive undergoes controlled crosslinking and decrosslinking processes, allowing for precise modulation of bond strength. This adaptability is critical in applications requiring reworkability or recyclability, as it allows for easy disassembly and reassembly of bonded components without compromising the integrity of the material. This study focuses on the sustainable synthesis and characterisation of a solvent-based polyurethane adhesive, obtained by functionalising a polyurethane prepolymer with DA diene and dienophiles. The characterisation of the adhesives was carried out using different experimental techniques: nuclear magnetic resonance spectroscopy (NMR), Brookfield viscosity, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and T-peel strength testing of leather/adhesive/rubber joints to determine the adhesive properties, both before and after the application of external stimuli. The conversion of both the DA and retro-Diels–Alder (r-DA) reactions was confirmed by 1H-NMR. The adhesive properties were not altered by the functionalisation of the adhesive prepolymer, showing similar thermal resistance and good rheological and adhesive properties, even exceeding the most demanding technical requirements for upper-to-sole joints in footwear. After the application of an external thermal stimuli, the bonded materials separated without difficulty and without damage, thus facilitating their separation, recovery and recycling.

Published
2023

19. Seguridad, inclusión y tecnología: una solución tecnológica para situaciones de emergencia

Author

Universitat Rovira i Virgili, Molero-Aranda, T., Lázaro Cantabrana, J. L., & Gisbert Cervera, M., Universitat Rovira i Virgili, and Molero-Aranda, T., Lázaro Cantabrana, J. L., & Gisbert Cervera, M.

Abstract

La seguridad, así como el acceso a la información y formación relativa a la prevención es un derecho que todas las personas deben tener garantizado. Este no es el caso de la mayoría de las personas con discapacidad intelectual (DI), quienes pueden presentar numerosas dificultades para desenvolverse en situaciones de emergencia. El proyecto SIT (Seguridad, Inclusión y Tecnología)se centra en el diseño y desarrollo de una solución tecnológica que permita la identificación, atención y formación preventiva de personas con DI en situaciones de emergencia con el fin de mejorar así su autodeterminación y calidad de vida. Para ello hemos utilizado la metodología de la Investigación Basada en el Diseño (DBR) como método de investigación por su característica cíclica de refinamiento de los productos diseñados. Esto nos ha permitido validar el contenido de la aplicación SOSDI y la web del proyecto SIT en sus versiones teóricas finales. En este artículo podrán encontrar el flujo de uso, la definición detallada de cada una de las partes de los productos, así como los aspectos de accesibilidad que se han tenido en cuenta para garantizar la accesibilidad cognitiva.

Published
2023

20. Polyurethane Adhesives with Chemically Debondable Properties via Diels–Alder Bonds.

Author

Carbonell-Blasco, María Pilar, Moyano, María Alejandra, Hernández-Fernández, Carlota, Sierra-Molero, Francisco J., Pastor, Isidro M., Alonso, Diego A., Arán-Aís, Francisca, and Orgilés-Calpena, Elena

Subjects
DIELS-Alder reaction, NUCLEAR magnetic resonance spectroscopy, ADHESIVES, POLYURETHANES, ADHESIVE joints, DIFFERENTIAL scanning calorimetry
Abstract

Covalent adaptable networks (CANs) represent a pioneering advance in polymer science, offering unprecedented versatility in materials design. Unlike conventional adhesives with irreversible bonds, CAN-based polyurethane adhesives have the unique ability to undergo chemical restructuring through reversible bonds. One of the strategies for incorporating these types of reactions in polyurethanes is by functionalisation with Diels–Alder (DA) adducts. By taking advantage of the reversible nature of the DA chemistry, the adhesive undergoes controlled crosslinking and decrosslinking processes, allowing for precise modulation of bond strength. This adaptability is critical in applications requiring reworkability or recyclability, as it allows for easy disassembly and reassembly of bonded components without compromising the integrity of the material. This study focuses on the sustainable synthesis and characterisation of a solvent-based polyurethane adhesive, obtained by functionalising a polyurethane prepolymer with DA diene and dienophiles. The characterisation of the adhesives was carried out using different experimental techniques: nuclear magnetic resonance spectroscopy (NMR), Brookfield viscosity, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and T-peel strength testing of leather/adhesive/rubber joints to determine the adhesive properties, both before and after the application of external stimuli. The conversion of both the DA and retro-Diels–Alder (r-DA) reactions was confirmed by 1H-NMR. The adhesive properties were not altered by the functionalisation of the adhesive prepolymer, showing similar thermal resistance and good rheological and adhesive properties, even exceeding the most demanding technical requirements for upper-to-sole joints in footwear. After the application of an external thermal stimuli, the bonded materials separated without difficulty and without damage, thus facilitating their separation, recovery and recycling. [ABSTRACT FROM AUTHOR]

Published
2024
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23. EL CLARINETE: LA SONORIDAD QUE INSPIRÓ A LOS GRANDES COMPOSITORES

Author

Juan J. Amores Molero

Abstract

Desde que el clarinetista alemán Johann Christoph Denner le añadiera la primera llave al antiguo chalumeau francés en el siglo XVII, inventando así el antecesor del clarinete, el peculiar sonido del instrumento ha sido objeto de estudio. A lo a lo largo de la historia, son muchos los que han intentado analizar el comportamiento acústico y las características particulares del tubo de este instrumento que, ya en su forma más primitiva, llegó a entusiasmar a compositores como Stamitz, Mozart, Weber, Brahms, ... Seguidamente revisaremos los fundamentos de la sonoridad que lo caracteriza, y, siguiendo la evolución del instrumento, trataremos de ofrecer nuestra visión de cuáles fueron las cualidades del mismo que inspiraron a los distintos compositores en los principales estilos musicales. Para ello nos fijaremos en obras de algunos de los composi- tores más representativos de cada época (Barroco, Clasicismo, Romanticismo y siglo XX), para mostrar así cómo el grado de evolución del instrumento fue determinante para su utilización.

Published
2023
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25. Resistencia a la clindamicina inducida por eritromicina en cepas de Staphylococcus aureus de origen clínico

Author

Castellano González Maribel J, Perozo Mena Armindo J, Molero Cubillán Mariheddy de J, Montero Araujo Sinead del C, and Primera Rodríguez Francisco J

Subjects
Clindamicina, resistencia inducible, eritromicina, Staphylococcus aureus, Clindamycin, inducible resistance, erythromycin, Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
Abstract

Abstract: Staphylococcus aureus is an important pathogen involved in a series of infections whose impact is increased by its multiple factors of virulence and antimicrobial resistance. Erythromycin induced clindamycin resistance is a growing problem in various parts of the world. This study was retrospective and analyzed the behavior in response to antimicrobials of 4307 strains of Staphylococcus aureus isolated in a hospital in the city of Maracaibo between January 2006 and December 2013. The frequency of erythromycin-induced clindamycin resistance, its association with resistance to oxacillin and the biological origin of the samples from which the microorganism was isolated were determined. Susceptibility to oxacillin was checked by diffusion method with disk agar and the induced clindamycin resistance was evaluated using the D-test. 60 D-Test positive strains were detected (1.39%), of which 38 (63.33%) were sensitive to methicillin and 22 strains were resistant (36.67%. The total resistance to clindamycin (constitutive and induced) represented 31.43% (1354) of the total number of strains tested. The frequency of induced resistance to clindamycin in Staphylococcus aureus strains in the locality is still low for both methicillin sensitive and resistant strains. Resumen: Staphylococcus aureus es un importante patógeno involucrado en una serie de infecciones cuyo impacto se incrementa por sus múltiples factores de virulencia y su resistencia a los antimicrobianos. La resistencia a clindamicina inducida por eritromicina constituye un problema creciente en diversas partes del mundo. Este estudio fue de tipo retrospectivo y se analizó el comportamiento frente a los antimicrobianos de 4307 cepas de Staphylococcus aureus aisladas en un hospital de la ciudad de Maracaibo entre enero 2006 y diciembre de 2013. Se determinó la frecuencia de resistencia a clindamicina inducida por eritromicina, su asociación con la resistencia a oxacilina y el origen biológico de las muestras a partir de las cuales se aisló el microorganismo. La susceptibilidad a oxacilina se comprobó mediante el método de difusión con discos en agar y la resistencia inducida a clindamicina usando la prueba D-test. Se detectaron 60 cepas D-Test positivo (1,39%), de las cuales 38(63,33%) fueron sensibles a meticilina y 22 cepas fueron resistentes (36,67%). La resistencia total a clindamicina (constitutiva e inducida) representó el 31,43% (1354) del total de cepas evaluadas. La frecuencia de resistencia inducida a clindamicina en cepas de Staphylococcus aureus en la localidad es aún baja tanto en cepas sensibles como resistentes a meticilina.

Published
2015

27. Actions and attitudes on the immunized patients against SARS-CoV-2

Author

F J Martín Sánchez, Manuel Martínez-Sellés, Emilio Bouza, F J Rodríguez-Artalejo, A García-Botella, J González Del Castillo, M C Martín-Delgado, J M Molero García, Teresa Hernández-Sampelayo, J Gómez-Pavón, A García-Lledó, S Moreno Guillén, R Cantón, J Ruiz-Galiana, P De Lucas Ramos, and UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología

Subjects
gap COVID-19, Microbiology (medical), medicine.medical_specialty, COVID-19 Vaccines, COVID-19 de brecha, Medicina, variantes virales, Population, Review, Disease, vaccine escape, Asymptomatic, uso de mascarillas, Ambulatory care, Health care, Humans, Medicine, escape vacunal, vacunas, education, Intensive care medicine, Pharmacology, education.field_of_study, Diagnostic Tests, Routine, SARS-CoV-2, business.industry, Transmission (medicine), Social distance, COVID-19, COVID-19 screening, General Medicine, vaccines, use of masks, seguimiento de inmunizados, Vaccination, viral variants, despistaje de COVID, Attitude, SARS-CoV2, follow-up of immunized persons, medicine.symptom, business
Abstract

The access to COVID vaccines by millions of human beings and their high level of protection against the disease, both in its mild and severe forms, together with a plausible decrease in the transmission of the infection from vaccinated patients, has prompted a series of questions from the members of the College of Physicians of Madrid (ICOMEM) and the society. The ICOMEM Scientific Committee on this subject has tried to answer these questions after discussion and consensus among its members. The main answers can be summarized as follows: The occurrence of new SARS-CoV-2 infections in both vaccinated and previously infected patients is very low, in the observation time we already have. When breakthrough infections do occur, they are usually asymptomatic or mild and, purportedly, should have a lower capacity for transmission to other persons. Vaccinated subjects who have contact with a SARS-CoV-2 infected patient can avoid quarantine as long as they are asymptomatic, although this decision depends on variables such as age, occupation, circulating variants, degree of contact and time since vaccination. In countries with a high proportion of the population vaccinated, it is already suggested that fully vaccinated persons could avoid the use of masks and social distancing in most circumstances. Systematic use of diagnostic tests to assess the immune response or the degree of protection against reinfection after natural infection or vaccination is discouraged, since their practical consequences are not known at this time. The existing information precludes any precision regarding a possible need for future revaccination. This Committee considers that when mass vaccination of health care workers and the general population is achieved, SARS-CoV-2 screening tests could be avoided at least in outpatient care and in the case of exploratory procedures that do not require hospitalization. post-print 156 KB

Published
2021
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28. Persistence and viability of SARS-CoV-2 in primary infection and reinfections

Author

Manuel Martínez-Sellés, J Ruiz-Galiana, P De Lucas Ramos, F J Martín Sánchez, M C Martín-Delgado, A García-Botella, J Gómez-Pavón, J M Molero García, Emilio Bouza, F J Rodríguez-Artalejo, S Moreno Guillén, R Cantón, A García-Lledó, J González Del Castillo, Teresa Hernández-Sampelayo, and UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología

Subjects
Microbiology (medical), Rein-fection, Medicina, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Dinámica viral, Review, Disease, Asymptomatic, Persistence (computer science), Immune system, Pandemic, medicine, Humans, In patient, Pandemics, Viral genetic material recovery, Reinfección, Persistencia de PCR, Recuperación de material genético viral, Pharmacology, SARS-CoV-2, business.industry, Clinical course, COVID-19, General Medicine, Reinfection, Viral dynamics, Immunology, medicine.symptom, PCR Persistence, business
Abstract

Since the beginning of the SARS-CoV-2 epidemic, virus isolation in the infected patient was only possible for a short period of time and it was striking that this occurred constantly and did not provide guidance on the clinical course. This fact led to confusion about the efficacy of some of the drugs initially used, which seemed to have a high efficiency in viral clearance and proved ineffective in modifying the course of the disease. The immune response also did not prove to be definitive in terms of evolution, although most of the patients with very mild disease had a weak or no antibody response, and the opposite was true for the most severe patients. With whatever the antibody response, few cases have been re-infected after a first infection and generally, those that have, have not reproduced a spectrum of disease similar to the first infection. Among those re-infected, a large number have been asymptomatic or with very few symptoms, others have had a moderate picture and very few have had a poor evolution. Despite this dynamic of rapid viral clearance, laboratory tests were still able to generate positive results in the recovery of genomic sequences and this occurred in patients who were already symptom-free, in others who were still ill and in those who were very seriously ill. There was also no good correlate. For this reason and with the perspective of this year and the half of pandemic, we compiled what the literature leaves us in these aspects and anticipating that, as always in biology, there are cases that jump the limits of the general behavior of the dynamics of infection in general. post-print 116 KB

Published
2021
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31. Conocimientos, comportamiento y actitudes sexuales en adultos con discapacidad intelectual

Author

Irene M. Díaz Rodríguez, Mª Dolores Gil Llario, Rafael Ballester Arnal, Vicente Morell Mengual, and Rosa J. Molero Mañes

Subjects
discapacidad intelectual, prácticas de sexo seguro, relaciones de pareja, abuso sexual, Psychology, BF1-990
Abstract

En este trabajo se lleva a cabo un estudio exploratorio cuyo objetivo general es analizar el comportamiento sexual, y el nivel de conocimientos y actitudes relativas a las prácticas de sexo seguro en una muestra de personas con discapacidad intelectual para prevenir la violencia sexual hacia este colectivo. La muestra está compuesta por 78 personas (39 hombres y 39 mujeres) con discapacidad intelectual leve o moderada. Los resultados obtenidos mediante una entrevista estructurada indican que en el nivel de conocimientos sobre prácticas sexuales destaca que el 73.1% había mantenido relaciones sexuales, el 87.4% conocían los diferentes tipos de métodos anticonceptivos y el 56.3% confiaba en los profesionales y educadores para tratar temas relativos a la sexualidad. Estos resultados subrayan la necesidad de desarrollar programas de educación afectiva-sexual adecuados a este colectivo.

Published
2014
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32. Indicators of the quality of the foster care

Author

Rosa J. Molero Mañes, Mª Dolores Gil Llario, and Irene Mª Díaz Rodríguez

Subjects
acogimiento familiar, vínculos afectivos, integración, desarrollo, Psychology, BF1-990
Abstract

One of the difficulties in choosing the families who come to foster care is related to the lack of studies that indicate the features needed to support optimal integrated development of children in foster care and also help in the process both the family as the child to generate the necessary resources. The sample consisted of 53 families with 80 children in foster care for three years. The aim was to identify characteristics that allow promote the development of the child. The results underline the importance of establishing secure links between the child and the foster family, the integration of the child in the foster family (the emergence of a sense of belonging), the existence of children in the foster family and a sense of satisfaction with welcoming, by the foster family.

Published
2014
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33. Desorganización del apego y el trastorno traumático del desarrollo (ttd)

Author

Carmen Gayá Ballester, Rosa J. Molero Mañes, and Mª Dolores Gil Llario

Subjects
apego, desorganización del apego, disociación, desarrollo traumático, Psychology, BF1-990
Abstract

La calidad del desarrollo de los miembros de la familia depende de la calidad de las relaciones que han establecido. Desde esta perspectiva evolutiva, las interacciones tempranas padres-hijos van a constituir un aspecto central y básico de la teoría del apego de Bowlby. Mary Ainsworth nos permite establecer una clasificación de las conductas de apego y son Main y Solomon quienes nos aportan bajo la denominación de apego desorganizado los perfiles más complejos y perturbadores de las relaciones entre padres e hijos, relaciones que deben ser asimétricas y tienen un único sentido. En este trabajo ponemos de manifiesto las aportaciones relacionadas con el apego desorganizado su relación con el desarrollo de la personalidad y la necesidad de recoger criterios diagnósticos cuando las experiencias traumáticas son repetidas y acumulativas y tuvieron lugar muchos tiempo antes del reconocimiento de los síntomas.

Published
2014
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35. New variants of SARS-CoV-2

Author

M C Martín-Delgado, Emilio Bouza, S Moreno Guillén, J M Molero García, R Cantón, Manuel Martínez-Sellés, A García-Botella, J Gómez-Pavón, F J Martín Sánchez, J González Del Castillo, J Ruiz-Galiana, F J Rodríguez-Artalejo, A García-Lledó, Teresa Hernández-Sampelayo, and P De Lucas Ramos

Subjects
0301 basic medicine, Microbiology (medical), medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), variantes virales, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 030106 microbiology, Population, Vaccine resistance, Review, Biology, 03 medical and health sciences, 0302 clinical medicine, Development economics, medicine, Humans, escape vacunal, 030212 general & internal medicine, education, Pharmacology, education.field_of_study, SARS-CoV-2, Public health, Vaccination, COVID-19, General Medicine, vaccine resistance, Viral variants, viral variants, SARS-CoV2, Public Health
Abstract

The emergence and spread of new variants of SARS-CoV-2 has produced enormous interest due to their possible implication in the improved transmissibility of the virus, their consequences in the individual evolution of the infection, as well as in the possible escape from the immunity generated by the current vaccines. The variants that attract most attention are those of public health concern, including B.1.1.7 (UK), P.1 (Brazilian) and B.1.351 (South African). This list is extended by the variants of interest that emerge and are expanding in certain countries but are found sporadically in others, such as B.1.427 and B.1.429 (Californians) or B.1.617 (Indian). Whole genome sequencing or strategies specifically targeting the spicule gene are used in the microbiology laboratories for characterization and detection. The number of infected individuals, the sanitary situation of each country, epidemiological measures and vaccination strategies influence its dispersion and new variants are expected to emerge. This emergence can only be avoided today by increasing the vaccinated population in all countries and by not relaxing epidemiological containment measures. It is not excluded that in the future it will be necessary to revaccinate against new variants. post-print 186 KB

Published
2021
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36. Modelos de endemicidad a lo largo de un gradiente altitudinal en Sierra Nevada (España) y Lefka Ori (Creta, Grecia)

Author

R. Fernández-Calzado, D. Ghosn, M. Gottfried, G. Kazakis, J. Molero Mesa, H. Pauli, and A. Merzouki

Subjects
endemicidad, riqueza de plantas vasculares, montañas mediterráneas, islas, proyecto gloria, calentamiento climático, Ecology, QH540-549.5
Abstract

Objetivo: Las zonas de alta montaña en la región mediterránea europea son particularmente ricas en plantas vasculares endémicas. Nuestro objetivo es comparar los modelos altitudinales para la riqueza de plantas vasculares y la proporción de endemismos en dos regiones mediterráneas: Lefka Ori en la isla de Creta (Grecia) y Sierra Nevada en la Península Ibérica. Localización: Sierra Nevada, Granada (España); Lefka Ori, Creta (Grecia). Método: Los datos proceden de un muestreo estandarizado en varias cimas situadas a diferentes altitudes (GLORIA Multi-Summit approach; www.gloria.ac.at). El número de especies, tasas de endemicidad, y temperatura del suelo se compararon por medio de ANCOVA y regresión lineal. Resultados: Las dos regiones objeto de análisis, aunque similares climáticamente, muestran patrones llamativamente diferentes: en Sierra Nevada, la proporción de plantas vasculares endémicas (especies restringidas a Sierra Nevada) muestra un incremento gradual desde la cima más baja a la más alta. En contraste, la proporción de endemismos restringidos a Creta no fue significativamente diferente entre las cuatro cimas de Lefka Ori. Las tendencias observadas en ambas regiones fueron en gran parte consistentes con la distribución de las especies endémicas obtenida de las floras para cada región. Conclusiones principales: La posición geográfica de ambas regiones, por ejemplo. isla frente a continente, y la mayor elevación de Sierra Nevada se sugieren como las principales causas de las diferencias observadas. El alto grado de endemicidad en los ambientes fríos de las zonas bioclimáticas superiores de las montañas mediterráneas evidencia una marcada vulnerabilidad a los impactos del cambio climático. Por lo tanto, el seguimiento continuado e intensivo de las especies de montaña alrededor de la cuenca mediterránea, debería considerarse como una tarea investigadora prioritaria.

Published
2013
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37. Seguimiento de la diversidad de líquenes y cambio climático en Sierra Nevada (España)

Author

M.ª R. Fernández Calzado, M. Casares Porcel, J. Blanco Houston, and J. Molero Mesa

Subjects
seguimiento a largo plazo, biodiversidad, cambio climático, sierra nevada, españa, Ecology, QH540-549.5
Abstract

Los líquenes son organismos comunes en las zonas de alta montaña donde juegan un importante papel en el equilibrio de los ecosistemas. En los últimos años, el creciente interés por entender más acerca de sus interacciones con los factores abióticos ha motivado diversas investigaciones, algunas de las cuales han demostrado su valor como bioindicadores de las condiciones climáticas. En este contexto, centrándonos en los efectos del cambio climático en plantas vasculares de alta montaña y respaldados por el proyecto “Iniciativa para la investigación y el seguimiento global de los ambientes alpinos (GLORIA)”, se ha monitorizado por primera vez la diversidad de líquenes en Sierra Nevada con la intención de estudiar las posibles alteraciones que esta pueda sufrir causadas por el proceso de cambio climático. El objetivo de este artículo es el de dar a conocer la experiencia de seguimiento en el macizo y aportar los primeros resultados procedentes del análisis, tanto de la biodiversidad como estadístico, de los datos de muestreo.

Published
2013
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40. The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review.

Author

C Gonzalez-Donquiles, J Alonso-Molero, T Fernandez-Villa, L Vilorio-Marqués, A J Molina, and V Martín

Subjects
Medicine, Science
Abstract

BACKGROUND:Colorectal cancer is one of the most common cancers worldwide, and is influenced by the interplay of various factors, including a very strong genetic component. For instance, incorrect mitochondrial biogenesis is correlated with increased risk of developing colorectal cancer. Thus, it is important to understand the consequences of changes in both the expression and the correct function of the transcription factors that regulate mitochondrial biogenesis, namely NRF2. OBJECTIVES:The main objective of this paper is to characterise the relationship between NRF2 and colorectal cancer by compiling data from an exhaustive literature search. METHODS:Information was obtained by defining specific search terms and searching in several databases. After a strict selection procedure, data were tabulated and the relationships between articles were assessed by measuring heterogeneity and by constructing conceptual maps. RESULTS AND DISCUSSION:We found a general consensus in the literature that the presence of oxidizing agents as well as the inhibition of the NRF2 repressor Keap1 maintain NRF2 expression at basal levels. This predominantly exerts a cytoprotective effect on cells and decreases risk of colorectal cancer. However, if NRF2 is inhibited, protection against external agents disappears and risk of colorectal cancer increases. Interestingly, colorectal cancer risk is also increased when NRF2 becomes overexpressed. In this case, the increased risk arises from NRF2-induced inflammation and resistance to chemotherapy. CONCLUSION:The proper basal function of NRF2 and Keap1 are essential for preventing oncogenic processes in the colon. Consequently, any disruption to the expression of these genes can promote the genesis and progression of colon cancer.

Published
2017
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41. P11.25.B Adjuvant high precision hypofractionated radiotherapy for resected brain metastases: single-institutional experience

Author

Villalobos Monardes, M, primary, Comas Anton, S, additional, Álvarez Gracia, A, additional, Rosales Gonzalez, H, additional, Mañes Garcia, A, additional, Molero Savall, J, additional, Jové Teixido, J, additional, Moreno Lopéz, S, additional, Meca Santamaria, G, additional, Rodríguez Troyano, A, additional, Quintana Déniz, M, additional, and Villà Freixa, S, additional

Published
2022
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43. El cine de Román Chalbaud en el contexto de la semiosfera de la cultura y la globalización

Author

Írida J. García De Molero

Subjects
Román Chalbaud's cinema, staging, semiospheres of culture, globalization, Cine de Román Chalbaud, puesta en escena, semiosferas de la cultura, globalización
Abstract

En esta investigación parte de una hipótesis previa que pone en relación las distintas semiosferas de la cultura que circulan en el contexto globalizado del cine de Román Chalbaud. Se plantea como objetivo la explicación y reflexión de la semiosis textual lotmaniana del fenómeno de la globalización en la puesta en escena fílmica del cine chalbaudeano, a partir de la noción de identidad y de cambio en las mediaciones técnicas y tecnológicas. Se concluye que en esta puesta en escena fílmica con determinadas actividades situadas y el uso de las mediaciones técnicas y tecnológicas, el autor pone en circulación el concepto de lo propio identitario respecto a su relación con lo ajeno que es diverso y globalizado respecto al mundo y al otro social, permitiendo al espectador intérprete reflexionar acerca de las distintas semiosferas de la cultura venezolana y sus respectivos campos de sentido. &nbsp

Published
2022
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44. El complex Euphorbia esula-E. virgata (Euphorbiaceae) al nord-est de la península Ibèrica: precisions corològiques, ecològiques i taxonòmiques

Author

J. Molero, P. Aymerich, and A. Rovira

Subjects
conservació, dinàmica poblacional, distribució, euphorbia esula, euphorbia ×pseudovirgata, euphorbia virgata, fitodermologia, hàbitat, morfologia, Biology (General), QH301-705.5, Botany, QK1-989
Abstract

El hallazgo reciente de tres poblaciones del complejo Euphorbia esula-E. virgata (Euphorbiaceae) en el nordeste de la Península Ibérica (centro y sur de Cataluña) nos ha inducido a realizar un estudio macro y micromorfológico para establecer su identidad taxonómica. En esta zona tan sólo existían dos datos previos de plantas de este complejo, correspondientes a recolecciones de los años 1908/1909 (previamente identificadas como E. esula subsp. saratoi) y 1930 (E. esula s. l.). Según nuestros resultados, todo el material examinado (recolecciones recientes y antiguas) se puede atribuir a E. virgata, un taxon de área principal en el este de Europa, que encuentra en el nordeste de la Península Ibérica su límite suroccidental de distribución. Los caracteres macromorfológicos presentan un cierto grado de variación interpoblacional, y en algún caso los individuos se parecen mucho a las formas que suelen denominarse E. ×pseudovirgata, supuestamente híbridas entre E. virgata y E. esula, pero no es posible confirmar la presencia regional de este híbrido sin la realización de estudios complementarios. Con los resultados de este estudio, debe excluirse la presencia de E. esula subsp. esula de Cataluña, Valencia y Aragón. Las poblaciones actuales de E. virgata, muy localizadas pero densas, se sitúan en hábitats herbáceos con clara influencia antrópica (campos abandonados y bordes de carreteras y caminos), en suelos profundos bastante secos; estos hábitats son similares a los típicos de E. virgata en Europa oriental y central. Aparentemente se trata de poblaciones de carácter temporal, y en dos de las tres localidades recientes se ha confirmado que se han establecido con posterioridad a 2005. Los datos actuales sugieren que puede tratarse de una especie alóctona, pero considerando que se detectó ya hace un siglo, no se puede excluir que sea una autóctona rara con poblaciones itinerantes. [ct] La troballa recent de tres poblacions del complex Euphorbia esula-E. virgata (Euphorbiaceae) al nord-est de la península Ibèrica (centre i sud de Catalunya) ens ha induït a realitzar-ne un estudi macro i micromorfològic, per tal d’establir la seva identitat taxonòmica. En aquesta zona només existien dues dades prèvies de plantes d’aquest complex, corresponents a recol·leccions dels anys 1908/1909 (prèviament identificades com a E. esula subsp. saratoi) i 1930 (E. esula s. l.). Segons els nostres resultats, tot el material examinat (recol·leccions recents i antigues) es pot atribuir a E. virgata, un tàxon d’àrea principal a l’est d’Europa, que troba al nord-est de la península Ibèrica el seu límit sud-occidental de distribució. Els caràcters macromorfològics presenten un grau limitat de variabilitat interpoblacional, i en algun cas s’assemblen molt a les formes que solen anomenar-se E. ×pseudovirgata, suposadament híbrides entre E. virgata i E. esula, però sense estudis addicionals no és possible confirmar la presència regional d’aquest híbrid. Després d’aquest estudi cal excloure la presència d’E. esula subsp. esula de Catalunya, el Pais Valencià i l’Aragó. Les poblacions actuals d’E. virgata, molt localitzades però denses, es fan en hàbitats herbacis amb influència antròpica clara (camps abandonats i marges de carreteres i camins), en sòls profunds força secs; aquests hàbitats són similars als típics d’E. virgata a l’Europa central i oriental. Aparentment es tracta de poblacions de caràcter temporal, i en dues de les tres localitats s’ha confirmat un establiment posterior a 2005. Les dades actuals suggereixen que pot tractar-se d’una planta al·lòctona, però considerant que ja va ser detectada fa un segle, tampoc no es pot excloure que sigui una autòctona rara i amb poblacions itinerants.

Published
2012
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45. Seseli farrenyi: un endemisme empordanès en vies d'extinció?

Author

J. López-Pujol, M. C. Martinell, S. Massó, C. Blanché, and J. Molero

Subjects
amenaza, cataluña, conservación, declive, demografía, endemismo, especies invasoras, fragmentación, plan de recuperación, amenaça, catalunya, conservació, declivi, demografia, endemisme, espècies invasores, fragmentació, pla de recuperació, Biology (General), QH301-705.5, Botany, QK1-989
Abstract

Seseli farrenyi es un endemismo estrictamente catalán, que cuenta con un número muy reducido de poblaciones en la franja litoral norte del cabo de Creus (Alt Empordà). La especie ha sido catalogada como “En Peligro” (EN) según los criterios de la UICN basándose en una serie de estudios realizados a finales de los años noventa, incluyendo censos y cartografía detallada. Tras poco más de una década, la realización de un nuevo censo por parte del mismo equipo de investigadores revela una pérdida de más del 90% del total de individuos, así como la desaparición de la localidad clásica de la especie, justificando elevar su categoría de amenaza a “En Peligro Crítico” (CR). Una de las prioridades del plan de recuperación para esta especie (la redacción y aplicación del cual se deriva de la inclusión de S. farrenyi en el Catàleg de Flora Amenaçada de Catalunya) debería ser la realización de estudios demográficos que permitieran conocer las causas de este declive poblacional. [ct] Seseli farrenyi és un endemisme estrictament català, que compta amb un nombre molt reduït de poblacions a la franja litoral nord del cap de Creus (Alt Empordà). L’espècie ha estat catalogada com a “En Perill” (EN) segons els criteris de la UICN en base a una sèrie d’estudis realitzats a finals dels anys noranta, que van incloure un cens i una cartografia detallada. Després de poc més d’una dècada, un nou cens realitzat pel mateix equip d’investigadors revela una pèrdua de més de 90% del nombre total d’individus, junt amb la desaparició de la localitat clàssica de l’espècie, justificant elevar la seva categoria d’amenaça a “En Perill Crític” (CR). Una de les prioritats del pla de recuperació per a l’espècie (la redacció i aplicació del qual es deriva de la inclusió de S. farrenyi al Catàleg de Flora Amenaçada de Catalunya) hauria d’ésser la realització d’estudis demogràfics que permetin conèixer la causa del seu declivi poblacional.

Published
2010
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46. A configurable architecture for e-participatory budgeting support

Author

Cesar Alfaro, Javier Gomez, Jose M. Lavin, and Juan J. Molero

Subjects
participatory budgeting, e-participation, technology support, ICT, Political science (General), JA1-92
Abstract

Participatory budgets are emerging as a paradigm for participation. However, there are many variants of such experiences suggesting a look of general methodology. Moreover there is a little use of ICT in this application context. We present a configurable architecture for e-participatory budget formation support.

Published
2010

47. PO-1382 Moderate hypofractionation for prostate cancer with fiducials markers

Author

Molina Osorio, J.G., primary, Meca Santamaria, G., additional, Villalobos Monardes, M., additional, Moreno López, S., additional, Ballester Alabau, R., additional, Álvarez Gracia, A., additional, Comas Anton, S., additional, Jové Teixido, J., additional, Caro Gallarin, M., additional, Prats Cabeces, L., additional, Luguera Sanchez, E., additional, Molero Savall, J., additional, and Villà Freixa, S., additional

Published
2022
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48. Booster or additional vaccination doses in patients vaccinated against COVID-19

Author

A García-Botella, Emilio Bouza, F J Rodríguez-Artalejo, M C Martín-Delgado, J González Del Castillo, Manuel Martínez-Sellés, F J Martín Sánchez, J M Molero García, J Ruiz-Galiana, Teresa Hernández-Sampelayo, J Gómez-Pavón, P De Lucas Ramos, S Moreno Guillén, R Cantón, and A García-Lledó

Subjects
Microbiology (medical), medicine.medical_specialty, COVID-19 Vaccines, Third dose, Population, Disease, Scientific literature, Booster dose, Lower risk, medicine, Humans, Intensive care medicine, Adverse effect, education, Aged, Pharmacology, education.field_of_study, Vaccines, Booster (rocketry), Additional doses, SARS-CoV-2, business.industry, Vaccination, COVID-19, General Medicine, Booster, SARS-CoV2, business
Abstract

Several health organizations, mainly in Western countries, have recently authorized the use of a booster dose of the COVID-19 vaccine for patients previously vaccinated with mRNA vaccines, with criteria that do not always coincide. The COVID Scientific Committee of the Illustrious College of Physicians of Madrid (ICOMEM) has received and asked several questions about this situation, to which the group has tried to give answers, after deliberation and consensus. The efficacy of the vaccines administered so far is beyond doubt and they have managed to reduce, fundamentally, the severe forms of the disease. The duration of this protection is not well known, is different in different individuals and for different variants of the virus and is not easily predictable with laboratory tests. Data on the real impact of a supplementary or “booster” dose in the scientific literature are scarce for the moment and its application in large populations such as those in the state of Israel may be associated with a decrease in the risk of new and severe episodes in the short observation period available. We also lack sufficient data on the safety and potential adverse effects of these supplementary doses and we do not know the ideal time to administer them in different situations. In this state of affairs, it seems prudent to administer supplemental doses to those exposed to a higher risk, such as immunocompromised individuals and the elderly. On the other hand, we consider that this is not the time to accelerate, on the spur of the moment, a massive administration of a third dose to other population groups that are less exposed and at lower risk, without waiting for adequate scientific information, which will undoubtedly arrive gradually. We do not believe that this position is incompatible with the practical and ethical warnings made by the World Health Organization in this respect. post-print 162 KB

Published
2022

49. Associations between food portion sizes, insulin resistance, VO2 max and metabolic syndrome in European adolescents: The HELENA study

Author

S.M. Flieh, M.L. Miguel-Berges, I. Huybrechts, M.J. Castillo, M. Gonzalez-Gross, A. Marcos, F. Gottrand, C. Le Donne, K. Widhalm, D. Molnár, P. Stehle, A. Kafatos, J. Dallongeville, E. Gesteiro, S. Abbeddou, L.A. Moreno, E.M. González-Gil, null Coordinator, null Core Group members, S. De Henauw, M. González-Gross, C. Gilbert, null Steering Committee, C. Libersa, S. Castelló, M. Kersting, M. Sjöstrom, G. Hall, L. Maes, L. Scalfi, null Project Manager, P. Meléndez, J.A. Casajús, J. Fleta, G. Rodríguez, C. Tomás, M.I. Mesana, G. Vicente-Rodríguez, A. Villarroya, C.M. Gil, I. Ara, J.F. Alvira, G. Bueno, O. Bueno, J.F. León, J.Ma Garagorri, I. Labayen, I. Iglesia, S. Bel, L.A. Gracia Marco, T. Mouratidou, A. Santaliestra-Pasías, E. González-Gil, P. De Miguel-Etayo, M. Miguel-Berges, I. Iguacel, A. Rupérez, J. Wärnberg, E. Nova, S. Gómez, L.E. Díaz, J. Romeo, A. Veses, B. Zapatera, T. Pozo, D. Martínez, L. Beghin, C. Iliescu, J. Von Berlepsch, W. Sichert-Hellert, E. Koeppen, D. Molnar, E. Erhardt, K. Csernus, K. Török, S. Bokor, M. Angster, E.ö Nagy, O. Kovács, J. Répasi, C. Codrington, M. Plada, A. Papadaki, K. Sarri, A. Viskadourou, C. Hatzis, M. Kiriakakis, G. Tsibinos, C. Vardavas, M. Sbokos, E. Protoyeraki, M. Fasoulaki, K. Pietrzik, C. Breidenassel, A. Spinneker, J. Al-Tahan, M. Segoviano, A. Berchtold, C. Bierschbach, E. Blatzheim, A. Schuch, P. Pickert, Á. Gutiérrez, F.B. Ortega, J.R. Ruiz, E.G. Artero, V. España, D. Jiménez-Pavón, P. Chillón, C. Sánchez-Muñoz, M. Cuenca, null former INRAN, D. Arcella, E. Azzini, E. Barrison, N. Bevilacqua, P. Buonocore, G. Catasta, L. Censi, D. Ciarapica, P. D'Acapito, M. Ferrari, M. Galfo, C. Leclercq, G. Maiani, B. Mauro, L. Mistura, A. Pasquali, R. Piccinelli, A. Polito, R. Roccaldo, R. Spada, S. Sette, M. Zaccaria, P. Vitaglione, C. Montagnese, I. De Bourdeaudhuij, T. De Vriendt, C. Matthys, C. Vereecken, M. de Maeyer, C. Ottevaere, K. Phillipp, S. Dietrich, B. Kubelka, M. Boriss-Riedl, Y. Manios, E. Grammatikaki, Z. Bouloubasi, T.L. Cook, S. Eleutheriou, O. Consta, G. Moschonis, I. Katsaroli, G. Kraniou, S. Papoutsou, D. Keke, I. Petraki, E. Bellou, S. Tanagra, K. Kallianoti, D. Argyropoulou, S. Tsikrika, C. Karaiskos, A. Meirhaeghe, M. Hagströmer, A.H. Wennlöf, L. Hallström, E. Patterson, L. Kwak, N. Rizzo, J. Sánchez-Molero, E. Picó, M. Navarro, B. Viadel, J.E. Carreres, G. Merino, R. Sanjuán, M. Lorente, M.J. Sánchez, S. Thoma-IRs, E. Allchurch, P. Burgess, A. Astrom, A. Sverkén, A. Broberg, A. Masson, C. Lehoux, P. Brabant, P. Pate, L. Fontaine, A. Sebok, T. Kuti, A. Hegyi, C. Maldonado, A. Llorente, E. García, H. von Fircks, M.L. Hallberg, M. Messerer, M. Larsson, H. Fredriksson, V. Adamsson, I. Börjesson, L. Fernández, L. Smillie, J. Wills, R. Pedrero-Chamizo, A. Meléndez, J. Valtueña, U. Albers, P.J. Benito, J.J. Gómez Lorente, D. Cañada, A. Urzanqui, R.M. Torres, P. Navarro, European Commission, Agencia Estatal de Investigación (España), and Ministerio de Ciencia, Innovación y Universidades (España)

Subjects
Male, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), CHILDREN, Adolescents, Endocrinology, Medicine and Health Sciences, QUERCETIN, Humans, YOUTH HEART, OVERWEIGHT, Nutrition and Dietetics, Food portion size (PS), Portion Size, Insulin resistance, Metabolic syndrome, Food portion size, Metabolic syndrome (MS), Diabetes and Metabolism, DIETARY PATTERNS, PHYSICAL-ACTIVITY, OBESITY, RISK-FACTORS, Insulin resistance (IR), LIFE-STYLE, NUTRITION, Female, Dairy Products, Sugars, Cardiology and Cardiovascular Medicine, VO2 max
Abstract

HELENA Study Group: et al., [Background and aims] This study aims to examine the associations of food portion size (PS) with markers of insulin resistance (IR) and clustered of metabolic risk score in European adolescents., [Methods] A total of 495 adolescents (53.5% females) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study were included. The association between PS from food groups and homeostasis model assessment of insulin resistance (HOMA-IR) index, VO2 max, and metabolic risk score was assessed by multilinear regression analysis adjusting for several confounders. Analysis of covariance (ANCOVA) was used to determine the mean differences of food PS from food groups by HOMA-IR cutoff categories by using maternal education as a covariable., [Results] Larger PS from vegetables in both gender and milk, yoghurt, and milk beverages in males were associated with higher VO2 max, while larger PS from margarines and vegetable oils were associated with lower VO2 max (p < 0.05). Males who consumed larger PS from fish and fish products; meat substitutes, nuts, and pulses; cakes, pies, and biscuits; and sugar, honey, jams, and chocolate have a higher metabolic risk score (p < 0.05). Males with lower HOMA-IR cutoff values consumed larger PS from vegetables, milk, yoghurt, and milk beverages (p < 0.05). Females with lower HOMA-IR cutoff values consumed larger PS from breakfast cereals, while those with higher HOMA-IR cutoff values consumed larger PS from butter and animal fats (p = 0.018)., [Conclusion] The results show that larger PS from dairy products, cereals, and high energy dense foods are a significant determinant of IR and VO2 max, and larger PS from food with higher content of sugar were associated with higher metabolic risk score., HELENA study received funding from the European Community Sixth RTD Framework Program (Contract FOODCT-2005-007034). E.M.G.-G. holds a Juan de la Cierva-Formación grant from the Spanish Government (FJCI-2017-34,967).

Published
2022

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