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17 results on '"Molbay, Muge"'

1. Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning

Author

Luo, Jie, Molbay, Muge, Chen, Ying, Horvath, Izabela, Kadletz, Karoline, Kick, Benjamin, Zhao, Shan, Al-Maskari, Rami, Singh, Inderjeet, Ali, Mayar, Bhatia, Harsharan Singh, Minde, David-Paul, Negwer, Moritz, Hoeher, Luciano, Calandra, Gian Marco, Groschup, Bernhard, Su, Jinpeng, Kimna, Ceren, Rong, Zhouyi, Galensowske, Nikolas, Todorov, Mihail Ivilinov, Jeridi, Denise, Ohn, Tzu-Lun, Roth, Stefan, Simats, Alba, Singh, Vikramjeet, Khalin, Igor, Pan, Chenchen, Arús, Bernardo A., Bruns, Oliver T., Zeidler, Reinhard, Liesz, Arthur, Protzer, Ulrike, Plesnila, Nikolaus, Ussar, Siegfried, Hellal, Farida, Paetzold, Johannes, Elsner, Markus, Dietz, Hendrik, and Erturk, Ali

Published
2025
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3. Distinct molecular profiles of skull bone marrow in health and neurological disorders

Author

Kolabas, Zeynep Ilgin, Kuemmerle, Louis B., Perneczky, Robert, Förstera, Benjamin, Ulukaya, Selin, Ali, Mayar, Kapoor, Saketh, Bartos, Laura M., Büttner, Maren, Caliskan, Ozum Sehnaz, Rong, Zhouyi, Mai, Hongcheng, Höher, Luciano, Jeridi, Denise, Molbay, Muge, Khalin, Igor, Deligiannis, Ioannis K., Negwer, Moritz, Roberts, Kenny, Simats, Alba, Carofiglio, Olga, Todorov, Mihail I., Horvath, Izabela, Ozturk, Furkan, Hummel, Selina, Biechele, Gloria, Zatcepin, Artem, Unterrainer, Marcus, Gnörich, Johannes, Roodselaar, Jay, Shrouder, Joshua, Khosravani, Pardis, Tast, Benjamin, Richter, Lisa, Díaz-Marugán, Laura, Kaltenecker, Doris, Lux, Laurin, Chen, Ying, Zhao, Shan, Rauchmann, Boris-Stephan, Sterr, Michael, Kunze, Ines, Stanic, Karen, Kan, Vanessa W.Y., Besson-Girard, Simon, Katzdobler, Sabrina, Palleis, Carla, Schädler, Julia, Paetzold, Johannes C., Liebscher, Sabine, Hauser, Anja E., Gokce, Ozgun, Lickert, Heiko, Steinke, Hanno, Benakis, Corinne, Braun, Christian, Martinez-Jimenez, Celia P., Buerger, Katharina, Albert, Nathalie L., Höglinger, Günter, Levin, Johannes, Haass, Christian, Kopczak, Anna, Dichgans, Martin, Havla, Joachim, Kümpfel, Tania, Kerschensteiner, Martin, Schifferer, Martina, Simons, Mikael, Liesz, Arthur, Krahmer, Natalie, Bayraktar, Omer A., Franzmeier, Nicolai, Plesnila, Nikolaus, Erener, Suheda, Puelles, Victor G., Delbridge, Claire, Bhatia, Harsharan Singh, Hellal, Farida, Elsner, Markus, Bechmann, Ingo, Ondruschka, Benjamin, Brendel, Matthias, Theis, Fabian J., and Erturk, Ali

Published
2023
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4. Spatial proteomics in three-dimensional intact specimens

Author

Bhatia, Harsharan Singh, Brunner, Andreas-David, Öztürk, Furkan, Kapoor, Saketh, Rong, Zhouyi, Mai, Hongcheng, Thielert, Marvin, Ali, Mayar, Al-Maskari, Rami, Paetzold, Johannes Christian, Kofler, Florian, Todorov, Mihail Ivilinov, Molbay, Muge, Kolabas, Zeynep Ilgin, Negwer, Moritz, Hoeher, Luciano, Steinke, Hanno, Dima, Alina, Gupta, Basavdatta, Kaltenecker, Doris, Caliskan, Özüm Sehnaz, Brandt, Daniel, Krahmer, Natalie, Müller, Stephan, Lichtenthaler, Stefan Frieder, Hellal, Farida, Bechmann, Ingo, Menze, Bjoern, Theis, Fabian, Mann, Matthias, and Ertürk, Ali

Published
2022
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8. Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in neuroinflammation

Author

Kolabas, Zeynep Ilgin, primary, Kuemmerle, Louis B., additional, Perneczky, Robert, additional, Förstera, Benjamin, additional, Büttner, Maren, additional, Caliskan, Ozum Sehnaz, additional, Ali, Mayar, additional, Rong, Zhouyi, additional, Mai, Hongcheng, additional, Hummel, Selina, additional, Bartos, Laura M., additional, Biechele, Gloria, additional, Zatcepin, Artem, additional, Albert, Natalie L., additional, Unterrainer, Marcus, additional, Gnörich, Johannes, additional, Zhao, Shan, additional, Khalin, Igor, additional, Rauchmann, Boris-Stephan, additional, Molbay, Muge, additional, Sterr, Michael, additional, Kunze, Ines, additional, Stanic, Karen, additional, Besson-Girard, Simon, additional, Kopczak, Anna, additional, Katzdobler, Sabrina, additional, Palleis, Carla, additional, Gokce, Ozgun, additional, Lickert, Heiko, additional, Steinke, Hanno, additional, Bechmann, Ingo, additional, Buerger, Katharina, additional, Levin, Johannes, additional, Haass, Christian, additional, Dichgans, Martin, additional, Havla, Joachim, additional, Kümpfel, Tania, additional, Kerschensteiner, Martin, additional, Simons, Mikael, additional, Plesnila, Nikolaus, additional, Krahmer, Natalie, additional, Bhatia, Harsharan Singh, additional, Erener, Suheda, additional, Hellal, Farida, additional, Brendel, Matthias, additional, Theis, Fabian J., additional, and Erturk, Ali, additional

Published
2021
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9. Proteomics of spatially identified tissues in whole organs

Author

Bhatia, Harsharan Singh, primary, Brunner, Andreas-David, additional, Rong, Zhouyi, additional, Mai, Hongcheng, additional, Thielert, Marvin, additional, Al-Maskari, Rami, additional, Paetzold, Johannes Christian, additional, Kofler, Florian, additional, Todorov, Mihail Ivilinov, additional, Ali, Mayar, additional, Molbay, Muge, additional, Kolabas, Zeynep Ilgin, additional, Kaltenecker, Doris, additional, Müller, Stephan, additional, Lichtenthaler, Stefan F., additional, Menze, Bjoern H., additional, Theis, Fabian J., additional, Mann, Matthias, additional, and Ertürk, Ali, additional

Published
2021
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10. Proteomics of spatially identified tissues in whole organs

Author

Bhatia, Harsharan Singh, Brunner, Andreas-David, Rong, Zhouyi, Mai, Hongcheng, Thielert, Marvin, Al-Maskari, Rami, Paetzold, Johannes Christian, Kofler, Florian, Todorov, Mihail Ivilinov, Ali, Mayar, Molbay, Muge, Kolabas, Zeynep Ilgin, Kaltenecker, Doris, Müller, Stephan, Lichtenthaler, Stefan F, Menze, Bjoern H, Theis, Fabian J, Mann, Matthias, Ertürk, Ali, and University of Zurich

Subjects
610 Medicine & health, 11493 Department of Quantitative Biomedicine
Published
2021
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11. Proteomics of spatially identified tissues in whole organs

Author

Bhatia, Harsharan Singh; https://orcid.org/0000-0001-9912-8263, Brunner, Andreas-David; https://orcid.org/0000-0002-2733-7899, Rong, Zhouyi; https://orcid.org/0000-0003-4849-1278, Mai, Hongcheng, Thielert, Marvin, Al-Maskari, Rami, Paetzold, Johannes Christian, Kofler, Florian, Todorov, Mihail Ivilinov, Ali, Mayar, Molbay, Muge, Kolabas, Zeynep Ilgin, Kaltenecker, Doris, Müller, Stephan, Lichtenthaler, Stefan F, Menze, Bjoern H; https://orcid.org/0000-0003-4136-5690, Theis, Fabian J; https://orcid.org/0000-0002-2419-1943, Mann, Matthias; https://orcid.org/0000-0003-1292-4799, Ertürk, Ali; https://orcid.org/0000-0001-5163-5100, Bhatia, Harsharan Singh; https://orcid.org/0000-0001-9912-8263, Brunner, Andreas-David; https://orcid.org/0000-0002-2733-7899, Rong, Zhouyi; https://orcid.org/0000-0003-4849-1278, Mai, Hongcheng, Thielert, Marvin, Al-Maskari, Rami, Paetzold, Johannes Christian, Kofler, Florian, Todorov, Mihail Ivilinov, Ali, Mayar, Molbay, Muge, Kolabas, Zeynep Ilgin, Kaltenecker, Doris, Müller, Stephan, Lichtenthaler, Stefan F, Menze, Bjoern H; https://orcid.org/0000-0003-4136-5690, Theis, Fabian J; https://orcid.org/0000-0002-2419-1943, Mann, Matthias; https://orcid.org/0000-0003-1292-4799, and Ertürk, Ali; https://orcid.org/0000-0001-5163-5100

Abstract

Spatial molecular profiling of complex tissues is essential to investigate cellular function in physiological and pathological states. However, methods for molecular analysis of biological specimens imaged in 3D as a whole are lacking. Here, we present DISCO-MS, a technology combining whole-organ imaging, deep learning-based image analysis, and ultra-high sensitivity mass spectrometry. DISCO-MS yielded qualitative and quantitative proteomics data indistinguishable from uncleared samples in both rodent and human tissues. Using DISCO-MS, we investigated microglia activation locally along axonal tracts after brain injury and revealed known and novel biomarkers. Furthermore, we identified initial individual amyloid-beta plaques in the brains of a young familial Alzheimer’s disease mouse model, characterized the core proteome of these aggregates, and highlighted their compositional heterogeneity. Thus, DISCO-MS enables quantitative, unbiased proteome analysis of target tissues following unbiased imaging of entire organs, providing new diagnostic and therapeutic opportunities for complex diseases, including neurodegeneration.

Published
2021

14. Human placental trophoblast progenitor cells (hTPCs) promote angiogenesis and neurogenesis after focal cerebral ischemia in rats.

Author

Molbay, Muge, Özaydın-Goksu, Eylem, Kipmen-Korgun, Dijle, Unal, Ali, Ozekinci, Murat, Cebeci, Erhan, Maltepe, Emin, and Korgun, Emin Turkay

Subjects
*CEREBRAL ischemia, *PROGENITOR cells, *TROPHOBLAST, *PLACENTA, *NEUROGENESIS, *PLACENTAL growth factor, *VASCULAR endothelial growth factors
Abstract

Reduction of blood flow below a threshold value in brain regions locally or globally is called cerebral ischemia and proper treatment requires either the restoration of normal blood flow and/or the administration of neuroprotective therapies. Human trophoblast progenitor cells (hTPCs) give rise to the placenta and are responsible for the invasion and vascular remodeling of the maternal vessels within the uterus. Here, we tested whether hTPCs promoted to differentiate along neural lineages may exhibit therapeutic properties in the setting of cerebral ischemia in vivo. Cerebral ischemia was generated in rats via middle cerebral artery occlusion and, after 24 h, hTPCs were injected systemically via tail vein. Animals were sacrified at Day 3 or 11. TTC staining indicated that infarct volumes were smaller in hTPC treated animals. Visible myelin recovery was observed in the hTPC injected group with Luxol Fast Blue staining. On Day 11 after hTPC transplantation, DLX5 and VEGF expression, as well as 2 and 10 d after hTPC transplantation, NKX2.2 were significantly increased; while LHX6, Olig1, PDGFRα, VEGFR1 and VEGFR2 showed trends toward improved expression in brain tissue via immunoblot analysis. Neuron-like differentiated cells were positive for both NeuN and Cresyl Violet staining. Here, we demonstrate for the first time that hTPCs enhance the expression of angiogenic and neurogenic factors in rat brain after stroke. Transplantation of hTPCs could form the basis of novel therapeutic approaches for the treatment of stroke in the clinical setting. [ABSTRACT FROM AUTHOR]

Published
2022
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15. Expression of glucose transporters in the human amnion derived mesenchymal stromal cells under normoglycemic and hyperglycemic conditions

Author

Unek, Gozde, primary, Cetinkaya, Busra, additional, Dogru, Segun, additional, Dogum, Karoline, additional, Molbay, Muge, additional, Ozmen, Asli, additional, Yanar, Kerem, additional, Kipmen-Korgun, Dijle, additional, Koksoy, Sadi, additional, Sakinci, Mehmet, additional, and Korgun, Emin Turkay, additional

Published
2019
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16. Human Trophoblast Progenitor Cells Express And Release Angiogenic Factors

Author

Molbay, Muge, Kipmen-Korgun, Dijle, Korkmaz, Gizem, Ozekinci, Murat, and Korgun, Emin Turkay

Subjects
embryonic structures
Abstract

Trophoblast stem cells develop from polar trophectoderm and give rise to the cells that generate the placenta. Trophoblast cells are responsible for the uterine invasion and vascular remodeling during the implantation of the embryo. However this knowledge is not yet to be confirmed for trophoblast progenitor cells (TPCs). In this study, we aimed to demonstrate that human TPCs (hTPCs) express and release angiogenic factors for the first time. TPCs were isolated from the term placenta. Then immunophenotyping was performed by FACS method by analyzing caudal type homeobox 2 (CDX2) and eomesodermin (EOMES). Immunofluorescence staining of CDX2 and EOMES was performed on these cells. Lastly, angiogenesis-related proteins were detected by western blot and ELISA assays. The isolated cells were positive for trophoblast stem cell markers CDX2 and EOMES in 92.5% and 92.7% of cells, respectively showing the characteristics of TPCs. The investigation of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor 1 (VEGFR1), and vascular endothelial growth factor receptor 2 (VEGFR2) at protein and mRNA level in comparison with human umbilical vein endothelial cells (HUVECs), revealed that human TPCs (hTPCs) have higher levels of VEGF and VEGFR1 transcripts. Additionally soluble forms of VEGF and VEGFR1 were detected in supernatants of hTPCs. With this information, TPCs seem to be promising for regenerative cell therapies by increasing angiogenesis.

Published
2018

17. Human Trophoblast Progenitor Cells Express and Release Angiogenic Factors.

Author

Molbay M, Kipmen-Korgun D, Korkmaz G, Ozekinci M, and Turkay Korgun E

Abstract

Trophoblast stem cells develop from polar trophectoderm and give rise to the cells that generate the placenta. Trophoblast cells are responsible for the uterine invasion and vascular remodeling during the implantation of the embryo. However this knowledge is not yet to be confirmed for trophoblast progenitor cells (TPCs). In this study, we aimed to demonstrate that human TPCs (hTPCs) express and release angiogenic factors for the first time. TPCs were isolated from the term placenta. Then immunophenotyping was performed by FACS method by analyzing caudal type homeobox 2 (CDX2) and eomesodermin (EOMES). Immunofluorescence staining of CDX2 and EOMES was performed on these cells. Lastly, angiogenesis-related proteins were detected by western blot and ELISA assays. The isolated cells were positive for trophoblast stem cell markers CDX2 and EOMES in 92.5% and 92.7% of cells, respectively showing the characteristics of TPCs. The investigation of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor 1 (VEGFR1), and vascular endothelial growth factor receptor 2 (VEGFR2) at protein and mRNA level in comparison with human umbilical vein endothelial cells (HUVECs), revealed that human TPCs (hTPCs) have higher levels of VEGF and VEGFR1 transcripts. Additionally soluble forms of VEGF and VEGFR1 were detected in supernatants of hTPCs. With this information, TPCs seem to be promising for regenerative cell therapies by increasing angiogenesis., Competing Interests: The authors declare that they have no conflict of interest.

Published
2018
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