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This paper extends the UTAUT 2 by adding the concept of irrational opposition to the adoption of a -wearable health tracker in a corporate -wellness setting. Our proposed model incorporates all of the UTAUT 2 constructs and adds the idea of irrational opposition. UTAUT 2's emphasis is more on the drivers of rational intention to adopt consumer technology. However, not all human behavior is rational. We develop a new theoretical model integrating both rational and irrational drivers of behavior. We also develop and validate an instrument for testing this model and provide recommendations on reducing the element of irrational opposition. [ABSTRACT FROM AUTHOR]

Introduction: The Alzheimer Disease (AD) is the most common form of dementia that leads to memory impairment. As the oxidative stress plays an important role in AD pathogenesis, the current study aimed at examining the protective effects of Cyperus Rotundus as an antioxidant on amyloid β (Aβ)-induced memory impairment. Methods: Twenty-eight Wistar male rats received intrahippocampal (IHP) injection of the Aβ (1-40) and C. rotundus (400 mg/kg, intraperitoneally). Spatial memory was assessed by the Morris water-maze (MWM) task. Results: In the MWM, Aβ (1-40) significantly increased escape latency and traveled distance (P<0.001). The administration of C. rotundus attenuated the Aβ-induced memory impairment in the MWM task. Conclusion: The current study findings showed that C. Rotundus could improve the learning impairment, following the Aβ treatment, and it may lead to an improvement of AD-induced cognitive dysfunction. [ABSTRACT FROM AUTHOR]

Introduction: 3-4, methylenedioxymethamphetamine (MDMA) causes apoptosis in nervous system and several studies suggest that oxidative stress contributes to MDMA-induced neurotoxicity. The aim of this study is to examine the effects of N-acetyl-L-Cystein (NAC) as an antioxidant on MDMAinduced apoptosis. Methods: 21 Sprague dawley male rats (200-250mg) were treated with MDMA (2x0,5mg/kg) or MDMA plus NAC (100mg/kg IP for 7 day). After last administration of MDMA, rats were killed, cerebellum was removed and Bax and Bcl-2 expression was assessed by western blotting method. Results: The results of this study showed that MDMA causes up-regulation of Bax and down-regulation of Bcl-2 and NAC administration attenuated MDMAinduced apoptosis. Discussion: The present study suggests that NAC treatment may improve MDMA-induced neurotoxicity. [ABSTRACT FROM AUTHOR]

Objective: The spice Zingiber officinale or ginger possesses antioxidant activity and neuroprotective effects. The effects of this traditional herbal medicine on 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity have not yet been studied. The present study considers the effects of Zingiber officinale on MDMA-induced spatial memory impairment and apoptosis in the hippocampus of male rats. Materials and Methods: In this experimental study, 21 adult male Sprague Dawley rats (200-250 g) were classified into three groups (control, MDMA, and MDMA plus ginger). The groups were intraperitoneally administered 10 mg/kg MDMA, 10 mg/kg MDMA plus 100 mg/kg ginger extract, or 1 cc/kg normal saline as the control solution for one week (n=7 per group). Learning memory was assessed by Morris water maze (MWM) after the last administration. Finally, the brains were removed to study the cell number in the cornu ammonis (CA1) hippocampus by light microscope, Bcl-2 by immunoblotting, and Bax expression by reverse transcription polymerase chain reaction (RT-PCR). Data was analyzed using SPSS 16 software and a one-way ANOVA test. Results: Escape latency and traveled distances decreased significantly in the MDMA plus ginger group relative to the MDMA group (p<0.001). Cell number increased in the MDMA plus ginger group in comparison to the MDMA group. Down-regulation of Bcl-2 and up-regulation of Bax were observed in the MDMA plus ginger group in comparison to the MDMA group (p<0.05). Conclusion: Our findings suggest that ginger consumption may lead to an improvement of MDMA-induced neurotoxicity. [ABSTRACT FROM AUTHOR]