Search

Your search keyword '"Mol Debes, Nanette"' showing total 28 results
Start Over Author "Mol Debes, Nanette"
28 results on '"Mol Debes, Nanette"'

1. Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome

Author

Jain, Pritesh, Miller-Fleming, Tyne, Topaloudi, Apostolia, Yu, Dongmei, Drineas, Petros, Georgitsi, Marianthi, Yang, Zhiyu, Rizzo, Renata, Müller-Vahl, Kirsten R., Tumer, Zeynep, Mol Debes, Nanette, Hartmann, Andreas, Depienne, Christel, Worbe, Yulia, Mir, Pablo, Cath, Danielle C., Boomsma, Dorret I., Roessner, Veit, Wolanczyk, Tomasz, Janik, Piotr, Szejko, Natalia, Zekanowski, Cezary, Barta, Csaba, Nemoda, Zsofia, Tarnok, Zsanett, Buxbaum, Joseph D., Grice, Dorothy, Glennon, Jeffrey, Stefansson, Hreinn, Hengerer, Bastian, Benaroya-Milshtein, Noa, Cardona, Francesco, Hedderly, Tammy, Heyman, Isobel, Huyser, Chaim, Morer, Astrid, Mueller, Norbert, Munchau, Alexander, Plessen, Kerstin J., Porcelli, Cesare, Walitza, Susanne, Schrag, Anette, Martino, Davide, Dietrich, Andrea, Mathews, Carol A., Scharf, Jeremiah M., Hoekstra, Pieter J., Davis, Lea K., and Paschou, Peristera

Published
2023
Full Text
View/download PDF

3. A Critical Examination of the Clinical Diagnosis of Functional Tic‐like Behaviors.

Author

Andersen, Kaja, Cavanna, Andrea Eugenio, Szejko, Natalia, Müller‐Vahl, Kirsten R., Hedderly, Tammy, Skov, Liselotte, and Mol Debes, Nanette

Subjects
TOURETTE syndrome, TIC disorders, BEHAVIOR disorders, YOUNG adults, NEUROLOGICAL disorders
Abstract

Background: Since the COVID‐19 pandemic, movement disorder clinics have seen an increase in patients with an unusual type of tic‐like symptoms: young adults with abrupt onset complex behaviors. It was quickly suspected that these patients suffered from functional neurological symptoms, later named Functional Tic‐Like Behaviors (FTLB). Subsequent research on the differential diagnosis between FTLB and tics has been substantial and led to the development of diagnostic checklists. Objectives: We conducted a theoretical reappraisal of the FTLB literature to clarify the validity of the concept and its diagnostic implications. Methods: This paper addresses several key aspects of the current FTLB literature: circular reasoning, the complications of the FTLB phenomenology and demographics, the impact of FTLB on tic literature at large, and issues with alignment of the FTLB concept with the diagnostic criteria for functional disorders. Results: The clinical approach to FTLB might involve circular reasoning due to a lack of clinical benchmarks. The FTLB phenomenology and demographics may need more work to ensure a lack of bias and a proper description of this patient group including a clear distinction from tics. The impact of the FTLB discussion on the wider literature needs consideration. The validation of positive signs may help with both these endeavors and pave way to the inclusion of FTLB within psychiatric classification systems. Furthermore, the coexistence of FTLB and tics within the same patient needs to be addressed. Conclusion: More research may be needed to fully establish the diagnosis of FTLB and differentiate it from tics. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

6. Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome

Author

National Institutes of Health (US), Lundbeck Foundation, German Research Foundation, Royal Netherlands Academy of Arts and Sciences, National Science Centre (Poland), National Institute for Health and Care Research (US), NIHR Biomedical Research Centre (UK), Jain, Pritesh, Miller-Fleming, Tyne, Topaloudi, Apostolia, Yu, Dongmei, Drineas, Petros, Georgitsi, Marianthi, Yang, Zhiyu, Rizzo, Renata, Müller-Vahl, Kirsten R., Tumer, Zeynep, Mol Debes, Nanette, Hartmann, Andreas, Depienne, Christel, Worbe, Yulia, Mir, Pablo, Cath, Danielle, Boomsma, Dorret I., Roessner, Veit, Wolańczyk, Tomasz, Janik, Piotr, Szejko, Natalia, Zekanowski, Cezary, Barta, Csaba, Nemoda, Zsofia, Tarnok, Zsanett, Buxbaum, Joseph D., Grice, Dorothy, Glennon, Jeffrey, Stefansson, Hreinn, Hengerer, Bastian, Benaroya‑Milshtein, Noa, Cardona, Francesco, Hedderly, Tammy, Heyman, Isobel, Huyser, Chaim, Morer, Astrid, Mueller, Norbert, Münchau, Alexander, Plessen, Kerstin J., Porcelli, Cesare, Walitza, Susanne, Schrag, Anette, Martino, Davide, The Psychiatric Genomics Consortium Tourette Syndrome Working Group (PGC-TS), The EMTICS collaborative group, Dietrich, Andrea, The TS-EUROTRAIN Network, Mathews, Carol A., Scharf, Jeremiah M., Hoekstra, Pieter J., Davis, Lea K., Paschou, Peristera, National Institutes of Health (US), Lundbeck Foundation, German Research Foundation, Royal Netherlands Academy of Arts and Sciences, National Science Centre (Poland), National Institute for Health and Care Research (US), NIHR Biomedical Research Centre (UK), Jain, Pritesh, Miller-Fleming, Tyne, Topaloudi, Apostolia, Yu, Dongmei, Drineas, Petros, Georgitsi, Marianthi, Yang, Zhiyu, Rizzo, Renata, Müller-Vahl, Kirsten R., Tumer, Zeynep, Mol Debes, Nanette, Hartmann, Andreas, Depienne, Christel, Worbe, Yulia, Mir, Pablo, Cath, Danielle, Boomsma, Dorret I., Roessner, Veit, Wolańczyk, Tomasz, Janik, Piotr, Szejko, Natalia, Zekanowski, Cezary, Barta, Csaba, Nemoda, Zsofia, Tarnok, Zsanett, Buxbaum, Joseph D., Grice, Dorothy, Glennon, Jeffrey, Stefansson, Hreinn, Hengerer, Bastian, Benaroya‑Milshtein, Noa, Cardona, Francesco, Hedderly, Tammy, Heyman, Isobel, Huyser, Chaim, Morer, Astrid, Mueller, Norbert, Münchau, Alexander, Plessen, Kerstin J., Porcelli, Cesare, Walitza, Susanne, Schrag, Anette, Martino, Davide, The Psychiatric Genomics Consortium Tourette Syndrome Working Group (PGC-TS), The EMTICS collaborative group, Dietrich, Andrea, The TS-EUROTRAIN Network, Mathews, Carol A., Scharf, Jeremiah M., Hoekstra, Pieter J., Davis, Lea K., and Paschou, Peristera

Abstract

Tourette Syndrome (TS) is a complex neurodevelopmental disorder characterized by vocal and motor tics lasting more than a year. It is highly polygenic in nature with both rare and common previously associated variants. Epidemiological studies have shown TS to be correlated with other phenotypes, but large-scale phenome wide analyses in biobank level data have not been performed to date. In this study, we used the summary statistics from the latest meta-analysis of TS to calculate the polygenic risk score (PRS) of individuals in the UK Biobank data and applied a Phenome Wide Association Study (PheWAS) approach to determine the association of disease risk with a wide range of phenotypes. A total of 57 traits were found to be significantly associated with TS polygenic risk, including multiple psychosocial factors and mental health conditions such as anxiety disorder and depression. Additional associations were observed with complex non-psychiatric disorders such as Type 2 diabetes, heart palpitations, and respiratory conditions. Cross-disorder comparisons of phenotypic associations with genetic risk for other childhood-onset disorders (e.g.: attention deficit hyperactivity disorder [ADHD], autism spectrum disorder [ASD], and obsessive-compulsive disorder [OCD]) indicated an overlap in associations between TS and these disorders. ADHD and ASD had a similar direction of effect with TS while OCD had an opposite direction of effect for all traits except mental health factors. Sex-specific PheWAS analysis identified differences in the associations with TS genetic risk between males and females. Type 2 diabetes and heart palpitations were significantly associated with TS risk in males but not in females, whereas diseases of the respiratory system were associated with TS risk in females but not in males. This analysis provides further evidence of shared genetic and phenotypic architecture of different complex disorders.

Published
2023

7. Søvnproblemer hos børn og unge

Author

Callesen, Henriette Edemann, Tarp, Simon, Ussing, Anja, Andersen, Henning Keinke, Sørensen, Anne Virring, Gade, Christina, Tornbjerg Pedersen, Inge, Krogh, Camilla, Dettmann Nielsen, Jette, Baandrup, Lone, Mol Debes, Nanette, Jennum, Poul, Laursen, Torben, Knattrup, Trine, and Vieth, Pernille

Abstract

Søvnproblemer er hyppigt forekommende og ses isoleret såvel som følgetilstand til anden sygdom [1, 2]. Behandlingen består altid af råd om god søvnhygiejne og ikke-farmakologiske tiltag. Ved utilstrækkelig effekt og hvis søvnproblemerne er udtalte med påvirket dagfunktion, kan behandling med sovemedicin såsom melatonin overvejes. Brug af melatonin er aldrig førstevalget, og man skal generelt være tilbageholdende med brug af lægemidler til søvnproblemer hos børn og unge [3,8]. Indenfor det seneste årti er der sket en markant stigning i forbruget af melatonin, hvoraf en betydelig del udskrives i almen praksis og en del også startes op i almen praksis (figur 1) [4]. Formålet med denne artikel er at give et overblik over hvordan søvnproblemer hos børn og unge bedst håndteres i almen praksis. Der fokuseres på samarbejdet mellem almen praksis og børne – og ungdomspsykiatrien og pædiatrien i forbindelse med udredning, behandling og opfølgning.

Published
2023

8. Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS)

Author

Paschou, Peristera, Jin, Yin, Müller-Vahl, Kirsten, Möller, Harald E., Rizzo, Renata, Hoekstra, Pieter J., Roessner, Veit, Mol Debes, Nanette, Worbe, Yulia, Hartmann, Andreas, Mir, Pablo, Cath, Danielle, Neuner, Irene, Eichele, Heike, Zhang, ChenCheng, Lewandowska, Katarzyna, Munchau, Alexander, Verrel, Julius, Musil, Richard, Silk, Tim J., Hanlon, Colleen A., Bihun, Emily D., Brandt, Valerie, Dietrich, Andrea, Forde, Natalie, Ganos, Christos, Greene, Deanna J., Chu, Chunguang, Grothe, Michel J., Hershey, Tamara, Janik, Piotr, Koller, Jonathan M., Martin-Rodriguez, Juan Francisco, Müller, Karsten, Palmucci, Stefano, Prato, Adriana, Ramkiran, Shukti, Saia, Federica, Szejko, Natalia, Torrecuso, Renzo, Tumer, Zeynep, Uhlmann, Anne, Veselinović, Tanja, Wolańczyk, Tomasz, Zouki, Jade-Jocelyne, Jain, Pritesh, Topaloudi, Apostolia, Kaka, Mary, Yang, Zhiyu, Drineas, Petros, Thomopoulos, Sophia I., White, Tonya, Veltman, Dick J., Schmaal, Lianne, Stein, Dan J., Buitelaar, Jan, Franke, Barbara, van den Heuvel, Odile, Jahanshad, Neda, Thompson, Paul M., Black, Kevin J., ENIGMA-TS Working Group, Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Neuroscience - Neurodegeneration, Clinical Cognitive Neuropsychiatry Research Program (CCNP), National Institute of Mental Health (US), National Science Foundation (US), Innovative Medicines Initiative, National Institutes of Health (US), Universidad de Sevilla, Lundbeck Foundation, Dagmar Marshall Foundation, Bøhmske Foundation, Hansen Memorial Foundation, Queen Louise’s Children’s Hospital Foundation, King Christian X’s Foundation, and Child and Adolescent Psychiatry / Psychology

Subjects
Psychiatry and Mental health, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], brain MRI, neuroimaging, SDG 3 - Good Health and Well-being, Brain MRI, Tourette syndrome, Genetics, ENIGMA, Neuroimaging, genetics, ddc:610
Abstract

Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns. Here, we present the scientific premise, perspectives, and key goals that have motivated the establishment of the Enhancing Neuroimaging Genetics through Meta-Analysis for TS (ENIGMA-TS) working group. The ENIGMA-TS working group is an international collaborative effort bringing together a large network of investigators who aim to understand brain structure and function in TS and dissect the underlying neurobiology that leads to observed comorbidity patterns and clinical heterogeneity. Previously collected TS neuroimaging data will be analyzed jointly and integrated with TS genomic data, as well as equivalently large and already existing studies of highly comorbid OCD, ADHD, ASD, MDD, and AXD. Our work highlights the power of collaborative efforts and transdiagnostic approaches, and points to the existence of different TS subtypes. ENIGMA-TS will offer large-scale, high-powered studies that will lead to important insights toward understanding brain structure and function and genetic effects in TS and related disorders, and the identification of biomarkers that could help inform improved clinical practice., This work was supported by NIMH grant no. 1R01MH126213 and NSF IIS grant no. 1715202 to PP, the Innovative Medicines Initiative 2 Joint Undertaking (grant no. 777394) to NF, the NIH (grant nos. R01MH118217 and K01MH104592) to DG, the NIH (grant nos. R01MH126213, R01MH116147, and P41EB015922) to NJ, the VI-PPIT-US from the University of Seville (grant no. USE-18817-A) to JM-R, the Lundbeck Foundation, the Dagmar Marshall Foundation, the Bøhmske Foundation, the Carpenter Jørgen Holm, and wife Elisa born Hansen Memorial Foundation, the Queen Louise’s Children’s Hospital Foundation, and the King Christian X Foundation to NM, the NIH (grant nos. R01MH126213, R01MH116147, and P41EB015922) to PT and ST.

Published
2022

9. ENIGMA-TS: a worldwide platform for collaboration on the study of Tourette Syndrome genetics and neuroimaging

Author

Paschou, Peristera, Jin, Yin, Müller-Vahl, Kirsten, Möller, Harald, Rizzo, Renata, Hoekstra, Pieter, Roessner, Veit, Mol Debes, Nanette, Worbe, Yulia, Hartmann, Andreas, Mir, Pablo, Cath, Danielle, Neuner, Irene, Eichele, Heike, Zhang, Chencheng, Szamburska-Lewandowska, Katarzyna, Muenchau, Alexander, Verrel, Julius, Musil, Richard, Silk, Tim, Hanlon, Colleen, Bihun, Emily, Brandt, Valerie, Dietrick, Andrea, Forde, Natalie, Ganos, Christos, Greene, Deanna, Chunguang, Chu, Grothe, Michel, Hershey, Tamara, Janik, Piotr, Koller, Jonathan, Rodriguez, Juan Francisco Martin, Mueller, Karsten, Palmucci, Stefano, Prato, Adriana, Ramkiran, Shukti, Saia, Federica, Szejko, Natalia, Torrecuso, Renzo, Tumer, Zeynep, Uhlmann, Anne, Veselinovic, Tanja, Wolanczyk, Tomasz, Zouki, Jace, Jain, Pritesh, Topaloudi, Apostolia, Kaka, Mary, Yang, Zhiyu, Drineas, Petros, Thomopoulos, Sophia, White, Tonya, Veltman, Dick, Schmaal, Lianne, Stein, Dan, Franke, Barbara, van den Heuvel, Odile, Jahanshad, Neda, Thompson, Paul, and Black, Kevin

Published
2022

10. Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS): A worldwide platform for collaboration

Author

National Institute of Mental Health (US), National Science Foundation (US), Innovative Medicines Initiative, National Institutes of Health (US), Universidad de Sevilla, Lundbeck Foundation, Dagmar Marshall Foundation, Bohemia Fund, Jeff Hansen Memorial Foundation, Queen Louise's Children's Hospital Foundation, King Christian X’s Foundation, Paschou, Peristera, Jin, Yin, Müller-Vahl, Kirsten R., Möller, Harald E., Rizzo, Renata, Hoekstra, Pieter J., Roessner, Veit, Mol Debes, Nanette, Worbe, Yulia, Hartmann, Andreas, Mir, Pablo, Cath, Danielle, Neuner, Irene, Eichele, Heike, Zhang, Chencheng, Lewandowska, Katarzyna, Münchau, Alexander, Verrel, Julius, Musil, Richard, Silk, Tim J., Hanlon, Colleen A., Bihun, Emily D., Brandt, Valerie, Dietrich, Andrea, Forde, Natalie, Ganos, Christos, Greene, Deanna J., Chu, Chunguang, Grothe, Michel J., Hershey, Tamara, Janik, Piotr, Koller, Jonathan M., Martín-Rodríguez, Juan Francisco, Müller, Karsten, Palmucci, Stefano, Prato, Adriana, Ramkiran, Shukti, Saia, Federica, Szejko, Natalia, Torrecuso, Renzo, Tumer, Zeynep, Uhlmann, Anne, Veselinovic, Tanja, Wolańczyk, Tomasz, Zouki, Jade Jocelyne, Jain, Pritesh, Topaloudi, Apostolia, Kaka, Mary, Yang, Zhiyu, Drineas, Petros, Thomopoulos, Sophia I., White, Tonya, Veltman, Dick J., Schmaal, Lianne, Stein, Dan J., Buitelaar, Jan, Franke, Barbara, Heuvel, Odile van den, Jahanshad, Neda, Thompson, Paul M., Black, Kevin J., National Institute of Mental Health (US), National Science Foundation (US), Innovative Medicines Initiative, National Institutes of Health (US), Universidad de Sevilla, Lundbeck Foundation, Dagmar Marshall Foundation, Bohemia Fund, Jeff Hansen Memorial Foundation, Queen Louise's Children's Hospital Foundation, King Christian X’s Foundation, Paschou, Peristera, Jin, Yin, Müller-Vahl, Kirsten R., Möller, Harald E., Rizzo, Renata, Hoekstra, Pieter J., Roessner, Veit, Mol Debes, Nanette, Worbe, Yulia, Hartmann, Andreas, Mir, Pablo, Cath, Danielle, Neuner, Irene, Eichele, Heike, Zhang, Chencheng, Lewandowska, Katarzyna, Münchau, Alexander, Verrel, Julius, Musil, Richard, Silk, Tim J., Hanlon, Colleen A., Bihun, Emily D., Brandt, Valerie, Dietrich, Andrea, Forde, Natalie, Ganos, Christos, Greene, Deanna J., Chu, Chunguang, Grothe, Michel J., Hershey, Tamara, Janik, Piotr, Koller, Jonathan M., Martín-Rodríguez, Juan Francisco, Müller, Karsten, Palmucci, Stefano, Prato, Adriana, Ramkiran, Shukti, Saia, Federica, Szejko, Natalia, Torrecuso, Renzo, Tumer, Zeynep, Uhlmann, Anne, Veselinovic, Tanja, Wolańczyk, Tomasz, Zouki, Jade Jocelyne, Jain, Pritesh, Topaloudi, Apostolia, Kaka, Mary, Yang, Zhiyu, Drineas, Petros, Thomopoulos, Sophia I., White, Tonya, Veltman, Dick J., Schmaal, Lianne, Stein, Dan J., Buitelaar, Jan, Franke, Barbara, Heuvel, Odile van den, Jahanshad, Neda, Thompson, Paul M., and Black, Kevin J.

Abstract

Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns. Here, we present the scientific premise, perspectives, and key goals that have motivated the establishment of the Enhancing Neuroimaging Genetics through Meta-Analysis for TS (ENIGMA-TS) working group. The ENIGMA-TS working group is an international collaborative effort bringing together a large network of investigators who aim to understand brain structure and function in TS and dissect the underlying neurobiology that leads to observed comorbidity patterns and clinical heterogeneity. Previously collected TS neuroimaging data will be analyzed jointly and integrated with TS genomic data, as well as equivalently large and already existing studies of highly comorbid OCD, ADHD, ASD, MDD, and AXD. Our work highlights the power of collaborative efforts and transdiagnostic approaches, and points to the existence of different TS subtypes. ENIGMA-TS will offer large-scale, high-powered studies that will lead to important insights toward understanding brain structure and function and genetic effects in TS and related disorders, and the identification of biomarkers that could help inform improved clinical practice.

Published
2022

11. Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS):A worldwide platform for collaboration

Author

Paschou, Peristera, Jin, Yin, Müller-Vahl, Kirsten, Möller, Harald E., Rizzo, Renata, Hoekstra, Pieter J., Roessner, Veit, Mol Debes, Nanette, Worbe, Yulia, Hartmann, Andreas, Mir, Pablo, Cath, Danielle, Neuner, Irene, Eichele, Heike, Zhang, Chencheng, Lewandowska, Katarzyna, Munchau, Alexander, Verrel, Julius, Musil, Richard, Silk, Tim J., Hanlon, Colleen A., Bihun, Emily D., Brandt, Valerie, Dietrich, Andrea, Forde, Natalie, Ganos, Christos, Greene, Deanna J., Chu, Chunguang, Grothe, Michel J., Hershey, Tamara, Janik, Piotr, Koller, Jonathan M., Martin-Rodriguez, Juan Francisco, Müller, Karsten, Palmucci, Stefano, Prato, Adriana, Ramkiran, Shukti, Saia, Federica, Szejko, Natalia, Torrecuso, Renzo, Tumer, Zeynep, Uhlmann, Anne, Veselinovic, Tanja, Wolańczyk, Tomasz, Zouki, Jade Jocelyne, Jain, Pritesh, Topaloudi, Apostolia, Kaka, Mary, Yang, Zhiyu, White, Tonya, Paschou, Peristera, Jin, Yin, Müller-Vahl, Kirsten, Möller, Harald E., Rizzo, Renata, Hoekstra, Pieter J., Roessner, Veit, Mol Debes, Nanette, Worbe, Yulia, Hartmann, Andreas, Mir, Pablo, Cath, Danielle, Neuner, Irene, Eichele, Heike, Zhang, Chencheng, Lewandowska, Katarzyna, Munchau, Alexander, Verrel, Julius, Musil, Richard, Silk, Tim J., Hanlon, Colleen A., Bihun, Emily D., Brandt, Valerie, Dietrich, Andrea, Forde, Natalie, Ganos, Christos, Greene, Deanna J., Chu, Chunguang, Grothe, Michel J., Hershey, Tamara, Janik, Piotr, Koller, Jonathan M., Martin-Rodriguez, Juan Francisco, Müller, Karsten, Palmucci, Stefano, Prato, Adriana, Ramkiran, Shukti, Saia, Federica, Szejko, Natalia, Torrecuso, Renzo, Tumer, Zeynep, Uhlmann, Anne, Veselinovic, Tanja, Wolańczyk, Tomasz, Zouki, Jade Jocelyne, Jain, Pritesh, Topaloudi, Apostolia, Kaka, Mary, Yang, Zhiyu, and White, Tonya

Abstract

Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns. Here, we present the scientific premise, perspectives, and key goals that have motivated the establishment of the Enhancing Neuroimaging Genetics through Meta-Analysis for TS (ENIGMA-TS) working group. The ENIGMA-TS working group is an international collaborative effort bringing together a large network of investigators who aim to understand brain structure and function in TS and dissect the underlying neurobiology that leads to observed comorbidity patterns and clinical heterogeneity. Previously collected TS neuroimaging data will be analyzed jointly and integrated with TS genomic data, as well as equivalently large and already existing studies of highly comorbid OCD, ADHD, ASD, MDD, and AXD. Our work highlights the power of collaborative efforts and transdiagnostic approaches, and points to the existence of different TS subtypes. ENIGMA-TS will offer large-scale, high-powered studies that will lead to important insights toward understanding brain structure and function and genetic effects in TS and related disorders, and the identification of biomarkers that could help inform improved clinical practice.

Published
2022

14. Association of Group AStreptococcusExposure and Exacerbations of Chronic Tic Disorders

Author

Martino, Davide, primary, Schrag, Anette, additional, Anastasiou, Zacharias, additional, Apter, Alan, additional, Benaroya-Milstein, Noa, additional, Buttiglione, Maura, additional, Cardona, Francesco, additional, Creti, Roberta, additional, Efstratiou, Androulla, additional, Hedderly, Tammy, additional, Heyman, Isobel, additional, Huyser, Chaim, additional, Madruga, Marcos, additional, Mir, Pablo, additional, Morer, Astrid, additional, Mol Debes, Nanette, additional, Moll, Natalie, additional, Müller, Norbert, additional, Müller-Vahl, Kirsten, additional, Munchau, Alexander, additional, Nagy, Peter, additional, Plessen, Kerstin Jessica, additional, Porcelli, Cesare, additional, Rizzo, Renata, additional, Roessner, Veit, additional, Schnell, Jaana, additional, Schwarz, Markus, additional, Skov, Liselotte, additional, Steinberg, Tamar, additional, Tarnok, Zsanett, additional, Walitza, Susanne, additional, Dietrich, Andrea, additional, and Hoekstra, Pieter J., additional

Published
2021
Full Text
View/download PDF

15. Association of Group A Exposure and Exacerbations of Chronic Tic Disorders: A Multinational Prospective Cohort Study.

Author

Martino, Davide, Schrag, Anette, Anastasiou, Zacharias, Apter, Alan, Benaroya-Milstein, Noa, Buttiglione, Maura, Cardona, Francesco, Creti, Roberta, Efstratiou, Androulla, Hedderly, Tammy, Heyman, Isobel, Huyser, Chaim, Madruga, Marcos, Mir, Pablo, Morer, Astrid, Mol Debes, Nanette, Moll, Natalie, Müller, Norbert, Müller-Vahl, Kirsten, and Munchau, Alexander

Published
2021
Full Text
View/download PDF

16. Functional neuroimaging in Tourette syndrome: recent perspectives

Author

Mol Debes,Nanette, Preel,Marie, and Skov,Liselotte

Subjects
mental disorders, Neuroscience and Neuroeconomics
Abstract

Nanette Mol Debes,Marie Préel,Liselotte Skov Pediatric Department, Tourette Clinic, Herlev University Hospital, Herlev, DenmarkAbstract: The most recent functional neuroimaging studies on Tourette syndrome (TS) are reviewed in this paper. Although it can be difficult to compare functional neuroimaging studies due to differences in methods, differences in age of the included subjects, and differences in the extent to which the presence of comorbidity, medical treatment, and severity of tics are considered in the various studies; most studies show that the cortico-striato-thalamo-cortical circuit seems to be involved in the generation of tics. Changes in this circuit seem to be correlated with tic severity. Correlations have been found between the presence of tics and hypermetabolism in various brain regions. Abnormalities of GABAergic, serotonergic, and dopaminergic neurotransmission in patients with TS have been suggested. During tic suppression, increased activity in the inferior frontal gyrus is seen. The premotor cortex might be involved in inhibition of motor control in subjects with TS. The right anterior insula is suggested to be a part of the urge–tic network. Several studies have shown altered motor network activations and sensorimotor gating deficits in subjects with TS. In future studies, inclusion of more well-defined subjects and further examination of premonitory urge and tic suppression is needed in order to increase the knowledge about the pathophysiology and treatment possibilities of TS. Keywords: functional neuroimaging, Tourette syndrome

Published
2017

17. Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort

Author

Bertelsen, Birgitte, Stefánsson, Hreinn, Riff Jensen, Lars, Melchior, Linea, Mol Debes, Nanette, Groth, Camilla, Skov, Liselotte, Werge, Thomas, Karagiannidis, Iordanis, Tarnok, Zsanett, Barta, Csaba, Nagy, Peter, Farkas, Luca, Brøndum-Nielsen, Karen, Rizzo, Renata, Gulisano, Mariangela, Rujescu, Dan, Kiemeney, Lambertus A, Tosato, Sarah, Nawaz, Muhammad Sulaman, Ingason, Andres, Unnsteinsdottir, Unnur, Steinberg, Stacy, Ludvigsson, Pétur, Stefansson, Kari, Kuss, Andreas Walter, Paschou, Peristera, Cath, Danielle, Hoekstra, Pieter J, Müller-Vahl, Kirsten, Stuhrmann, Manfred, Silahtaroglu, Asli, Pfundt, Rolph, Tümer, Zeynep, Bertelsen, Birgitte, Stefánsson, Hreinn, Riff Jensen, Lars, Melchior, Linea, Mol Debes, Nanette, Groth, Camilla, Skov, Liselotte, Werge, Thomas, Karagiannidis, Iordanis, Tarnok, Zsanett, Barta, Csaba, Nagy, Peter, Farkas, Luca, Brøndum-Nielsen, Karen, Rizzo, Renata, Gulisano, Mariangela, Rujescu, Dan, Kiemeney, Lambertus A, Tosato, Sarah, Nawaz, Muhammad Sulaman, Ingason, Andres, Unnsteinsdottir, Unnur, Steinberg, Stacy, Ludvigsson, Pétur, Stefansson, Kari, Kuss, Andreas Walter, Paschou, Peristera, Cath, Danielle, Hoekstra, Pieter J, Müller-Vahl, Kirsten, Stuhrmann, Manfred, Silahtaroglu, Asli, Pfundt, Rolph, and Tümer, Zeynep

Abstract

BACKGROUND: Gilles de la Tourette syndrome (GTS) is a complex neuropsychiatric disorder with a strong genetic influence where copy number variations are suggested to play a role in disease pathogenesis. In a previous small-scale copy number variation study of a GTS cohort (n = 111), recurrent exon-affecting microdeletions of four genes, including the gene encoding arylacetamide deacetylase (AADAC), were observed and merited further investigations.METHODS: We screened a Danish cohort of 243 GTS patients and 1571 control subjects for submicroscopic deletions and duplications of these four genes. The most promising candidate gene, AADAC, identified in this Danish discovery sample was further investigated in cohorts from Iceland, the Netherlands, Hungary, Germany, and Italy, and a final meta-analysis, including a total of 1181 GTS patients and 118,730 control subjects from these six European countries, was performed. Subsequently, expression of the candidate gene in the central nervous system was investigated using human and mouse brain tissues.RESULTS: In the Danish cohort, we identified eight patients with overlapping deletions of AADAC. Investigation of the additional five countries showed a significant association between the AADAC deletion and GTS, and a final meta-analysis confirmed the significant association (p = 4.4 × 10(-4); odds ratio = 1.9; 95% confidence interval = 1.33-2.71). Furthermore, RNA in situ hybridization and reverse transcription-polymerase chain reaction studies revealed that AADAC is expressed in several brain regions previously implicated in GTS pathology.CONCLUSIONS: AADAC is a candidate susceptibility factor for GTS and the present findings warrant further genomic and functional studies to investigate the role of this gene in the pathogenesis of GTS.

Published
2016

18. Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort

Author

Leerstoel Hout, Experimental psychopathology, Bertelsen, Birgitte, Stefánsson, Hreinn, Riff Jensen, Lars, Melchior, Linea, Mol Debes, Nanette, Groth, Camilla, Skov, Liselotte, Werge, Thomas, Karagiannidis, Iordanis, Tarnok, Zsanett, Barta, Csaba, Nagy, Peter, Farkas, Luca, Brøndum-Nielsen, Karen, Rizzo, Renata, Gulisano, Mariangela, Rujescu, Dan, Kiemeney, Lambertus A, Tosato, Sarah, Nawaz, Muhammad Sulaman, Ingason, Andres, Unnsteinsdottir, Unnur, Steinberg, Stacy, Ludvigsson, Pétur, Stefansson, Kari, Kuss, Andreas Walter, Paschou, Peristera, Cath, Danielle, Hoekstra, Pieter J, Müller-Vahl, Kirsten, Stuhrmann, Manfred, Silahtaroglu, Asli, Pfundt, Rolph, Tümer, Zeynep, Leerstoel Hout, Experimental psychopathology, Bertelsen, Birgitte, Stefánsson, Hreinn, Riff Jensen, Lars, Melchior, Linea, Mol Debes, Nanette, Groth, Camilla, Skov, Liselotte, Werge, Thomas, Karagiannidis, Iordanis, Tarnok, Zsanett, Barta, Csaba, Nagy, Peter, Farkas, Luca, Brøndum-Nielsen, Karen, Rizzo, Renata, Gulisano, Mariangela, Rujescu, Dan, Kiemeney, Lambertus A, Tosato, Sarah, Nawaz, Muhammad Sulaman, Ingason, Andres, Unnsteinsdottir, Unnur, Steinberg, Stacy, Ludvigsson, Pétur, Stefansson, Kari, Kuss, Andreas Walter, Paschou, Peristera, Cath, Danielle, Hoekstra, Pieter J, Müller-Vahl, Kirsten, Stuhrmann, Manfred, Silahtaroglu, Asli, Pfundt, Rolph, and Tümer, Zeynep

Published
2016

19. Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort

Author

Bertelsen, Birgitte, primary, Stefánsson, Hreinn, additional, Riff Jensen, Lars, additional, Melchior, Linea, additional, Mol Debes, Nanette, additional, Groth, Camilla, additional, Skov, Liselotte, additional, Werge, Thomas, additional, Karagiannidis, Iordanis, additional, Tarnok, Zsanett, additional, Barta, Csaba, additional, Nagy, Peter, additional, Farkas, Luca, additional, Brøndum-Nielsen, Karen, additional, Rizzo, Renata, additional, Gulisano, Mariangela, additional, Rujescu, Dan, additional, Kiemeney, Lambertus A., additional, Tosato, Sarah, additional, Nawaz, Muhammad Sulaman, additional, Ingason, Andres, additional, Unnsteinsdottir, Unnur, additional, Steinberg, Stacy, additional, Ludvigsson, Pétur, additional, Stefansson, Kari, additional, Kuss, Andreas Walter, additional, Paschou, Peristera, additional, Cath, Danielle, additional, Hoekstra, Pieter J., additional, Müller-Vahl, Kirsten, additional, Stuhrmann, Manfred, additional, Silahtaroglu, Asli, additional, Pfundt, Rolph, additional, and Tümer, Zeynep, additional

Published
2016
Full Text
View/download PDF

24. Idiopathic Localised Unilateral Hyperhidrosis in a 7-year-old Girl: A Case Report.

Author

Thorlacius, Linnea, Mol Debes, Nanette, Zachariae, Claus, and Kofoed, Kristian

Subjects
*HYPERHIDROSIS, *QUALITY of life, *PHYSIOLOGICAL stress, *PATHOLOGICAL physiology
Abstract

The article describes a case of a seven-year-old female patient with idiopathic localised unilateral hyperhidrosis. Topics cited include the effect excessive sweating on the patient's quality of life, role of stress in the prevalence of hyperhidrosis, clinical features and pathophysiology of hyperhidrosis, and association of hyperhidrosis with cerebral infarction and spinal cord injuries.

Published
2015
Full Text
View/download PDF

25. Tourette syndrome research highlights from 2023.

Author

Hartmann A, Andrén P, Atkinson-Clement C, Czernecki V, Delorme C, Mol Debes N, Morand-Beaulieu S, Müller-Vahl K, Paschou P, Szejko N, Topaloudi A, and Black KJ

Subjects
Humans, Biomedical Research trends, Tourette Syndrome therapy
Abstract

In this, the tenth annual update for the F1000Research Tics collection, we summarize research reports from 2023 on Gilles de la Tourette syndrome and other tic disorders. The authors welcome article suggestions and thoughtful feedback from readers., Competing Interests: Competing interests: AH is a consultant for Noema Pharma. PA has received royalties from the Tourette OCD Alberta Network. CD is a consultant for Medtronic. NMD has no conflicts of interest. VC has no conflict of interest. KU participated in a clinical trial sponsored by Emalex Biosciences. PP has no conflict of interest. AT has no conflict of interest. CAC has no conflict of interest. NSZ participated in clinical trial supported by Emalex and Nuvelution. She received scientific grants from the Polish Neurological Society, European Stroke Organisation, Polish Ministry of Health, Polish Foundation of Science, Tourette Association of America, American Academy of Neurology and American Brain Foundation. She received speaker honoraria from Biogen. PP was supported by EMTICS (Grant No. 278367), TS-EUROTRAIN (Grant No. 316978), the National Institute of Neurological Disorders and Stroke (Grant No. R01NS105746), U.S. National Science Foundation (Grant Nos. 2006929 and 1715202), and the National Institute of Mental Health (Grant No. R01MH126213). KMV has received financial or material research support from EU (FP7-HEALTH-2011 No. 278367, FP7-PEOPLE-2012-ITN No. 316978), DFG: GZ MU 1527/3-1 and GZ MU 1527/3-2, BMBF: 01KG1421, National Institute of Mental Health (NIMH), Tourette Gesellschaft Deutschland e.V., Else-Kröner-Fresenius-Stiftung, GW pharmaceuticals, Almirall, Abide Therapeutics, Emalex Biosciences, Inc., Noema Pharma, CannaXan, and Therapix Biosiences. She has received consultant's and other honoraria from Abide Therapeutics, adjupharm, Alexion, AMP Alternative Medical Products GmbH, Ingelheim International GmbH, Bionorica Ethics GmbH, CannaMedical Pharma GmbH, Canopy Grouth, Columbia Care, CTC Communications Corp., Demecan, Enua pharma, Ethypharm GmbH, Eurox Group, Global Praxis Group Limited, Hormosan Pharma GmbH, Lundbeck, MCI Germany, Neuraxpharm, Noema Pharma, Sanity Group, Stadapharm GmbH, Synendos Therapeutics AG, Syqe, Tilray, and Zambon. She is an advisory/scientific board member for Alexion, Branchenverband Cannabiswirtschaft e.V. (BvCW), CannaMedical Pharma GmbH, Bionorica Ethics GmbH, CannaXan GmbH, Canopy Growth, Columbia Care, Ethypharm GmbH, Hormosan Pharma GmbH, IMC Germany, Leafly Deutschland GmbH, Neuraxpharm, Sanity Group, Stadapharm GmbH, Synendos Therapeutics AG, Syqe Medical Ltd., Therapix Biosciences Ltd., and Tilray. She has received speakers fees from Agaplesion Frankfurter Diakonie Kliniken gemeinnützige GmbH, Almirall, Aphria Deutschland GmbH, Arbeitsgemeinschaft Cannabis als Medizin (ACM), Bedrocan, Branchenverband Cannabiswirtschaft e.V. (BvCW), Camurus, CEREBRO SPAIN BIDCO S.L, Cogitando GmbH, Deutsche Gesellschaft für Psychiatrie und Psychotherapie, Psychosomatik und Nervenheilkunde (DGPPN), Diplomado Internacional de Endocannabinología (Programa Universitario de Investigación en Salud - PUIS, UNAM), Dresden International University (DIU), Emalex, Eurox Deutschland GmbH, Ever pharma GmbH, Georgia Medical Cannabis Project (GMCP), GROW, Hessische Landesstelle für Suchtfragen e.V. (HLS), LIO Pharmaceuticals GmbH, Medizinischer Dienst Westfalen Lippe, Meinhardt Congress GmbH, PR Berater, Spectrum Therapeutics GmbH, Swiss Alpinopharm, targoEvent GmbH, Takeda GmbH, Tilray, von Mende Marketing GmbH, and Wayland Group. She has received royalties from Deutsches Ärzteblatt, Der Neurologie und Psychiater, Elsevier, Medizinisch Wissenschaftliche Verlagsgesellschaft Berlin, and Kohlhammer. She served as a guest editor for Frontiers in Neurology on the research topic "The neurobiology and genetics of Gilles de la Tourette syndrome: new avenues through large-scale collaborative projects", is an associate editor for "Cannabis and Cannabinoid Research", an Editorial Board Member of "Medical Cannabis and Cannabinoids" and "MDPI-Reports" and a scientific board member for "Zeitschrift für Allgemeinmedizin". SMB was supported by the Clinical Research Training Scholarship in Tourette syndrome from the Tourette Association of America and the American Brain Foundation, in collaboration with the American Academy of Neurology. PA has received funding from Region Skåne, The Crafoord Foundation, L.J. Boëthius Stiftelse, Stiftelsen Lindhaga, The Söderström Königska Foundation, Fredrik och Ingrid Thurings stiftelse, and The Sven Jerring Foundation outside the submitted work. KJB participated in a clinical trial sponsored by Emalex Biosciences and was an unpaid consultant for Noema Pharma AG; he received research support from Zhittya Genesis Medicine and from NIH (R01MH118217, UL1TR002345, R01MH126213, R21NS133875)., (Copyright: © 2024 Hartmann A et al.)

Published
2024
Full Text
View/download PDF

26. Association of Group A Streptococcus Exposure and Exacerbations of Chronic Tic Disorders: A Multinational Prospective Cohort Study.

Author

Martino D, Schrag A, Anastasiou Z, Apter A, Benaroya-Milstein N, Buttiglione M, Cardona F, Creti R, Efstratiou A, Hedderly T, Heyman I, Huyser C, Madruga M, Mir P, Morer A, Mol Debes N, Moll N, Müller N, Müller-Vahl K, Munchau A, Nagy P, Plessen KJ, Porcelli C, Rizzo R, Roessner V, Schnell J, Schwarz M, Skov L, Steinberg T, Tarnok Z, Walitza S, Dietrich A, and Hoekstra PJ

Subjects
Adolescent, Child, Child, Preschool, Cohort Studies, Europe epidemiology, Female, Humans, Male, Prospective Studies, Symptom Flare Up, Streptococcal Infections epidemiology, Tic Disorders epidemiology
Abstract

Objective: To examine prospectively the association between group A Streptococcus (GAS) pharyngeal exposures and exacerbations of tics in a large multicenter population of youth with chronic tic disorders (CTD) across Europe., Methods: We followed up 715 children with CTD (age 10.7 ± 2.8 years, 76.8% boys), recruited by 16 specialist clinics from 9 countries, and followed up for 16 months on average. Tic, obsessive-compulsive symptom (OCS), and attention-deficit/hyperactivity disorder (ADHD) severity was assessed during 4-monthly study visits and telephone interviews. GAS exposures were analyzed using 4 possible combinations of measures based on pharyngeal swab and serologic testing. The associations between GAS exposures and tic exacerbations or changes of tic, OC, and ADHD symptom severity were measured, respectively, using multivariate logistic regression plus multiple failure time analyses and mixed effects linear regression., Results: A total of 405 exacerbations occurred in 308 of 715 (43%) participants. The proportion of exacerbations temporally associated with GAS exposure ranged from 5.5% to 12.9%, depending on GAS exposure definition. We did not detect any significant association of any of the 4 GAS exposure definitions with tic exacerbations (odds ratios ranging between 1.006 and 1.235, all p values >0.3). GAS exposures were associated with longitudinal changes of hyperactivity-impulsivity symptom severity ranging from 17% to 21%, depending on GAS exposure definition., Conclusions: This study does not support GAS exposures as contributing factors for tic exacerbations in children with CTD. Specific workup or active management of GAS infections is unlikely to help modify the course of tics in CTD and is therefore not recommended., (© 2021 American Academy of Neurology.)

Published
2021
Full Text
View/download PDF

27. Association of the CHRNA7 promoter variant -86T with Tourette syndrome and comorbid obsessive-compulsive disorder.

Author

Bertelsen B, Melchior L, Groth C, Mol Debes N, Skov L, Holst KK, Fagerlund B, Mikkelsen JD, and Tümer Z

Subjects
Adult, Case-Control Studies, Comorbidity, Female, Genetic Variation genetics, Humans, Logistic Models, Male, Obsessive-Compulsive Disorder epidemiology, Obsessive-Compulsive Disorder genetics, Promoter Regions, Genetic, Tourette Syndrome epidemiology, Tourette Syndrome genetics, alpha7 Nicotinic Acetylcholine Receptor genetics
Published
2014
Full Text
View/download PDF

28. Sequence analysis of SLITRK1 for var321 in Danish patients with Tourette syndrome and review of the literature.

Author

Yasmeen S, Melchior L, Bertelsen B, Skov L, Mol Debes N, and Tümer Z

Subjects
3' Untranslated Regions, Base Sequence, Chromosomes, Human, DNA Primers, Denmark, Female, Humans, Male, Pedigree, Polymerase Chain Reaction, Membrane Proteins genetics, Nerve Tissue Proteins genetics, Tourette Syndrome genetics
Abstract

Tourette syndrome (TS) is a complex neuropsychiatric disorder characterized by multiple motor and vocal tics and is often accompanied by comorbidities such as attention deficit hyperactivity disorder and obsessive-compulsive disorder. The complex etiology of TS and its co-occurrence with other disorders impedes linking genetic changes with disease segregation. One of the few genes that has been linked to TS is the SLITRK1 (Slit and Trk-like 1) gene, where four variations have been suggested as possible disease-associated changes. One of these variations, which has been reported in six unrelated TS patients, was a noncoding variant (var321) at the 3'-untranslated region of SLITRK1 within a conserved binding site for microRNA has-mir-189. To elucidate the potential role of var321 in disease pathogenesis, a cohort of 112 deeply phenotyped Danish TS patients was investigated for this variation. We could not detect var321 in the present cohort, suggesting that this is not a common variant among Danish TS patients.

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results