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1. Novel scores relevant to antimicrobial resistance and hospital-acquired infections developed with data from a multi-hospital consortium in the Parisian region of France

Author

Lefevre, Laurence Armand, Aubry, Alexandra, Avettand-Fenoel, Véronique, Barbut, Frédéric, Belec, Laurent, Bercot, Béatrice, Bonacorsi, Stéphane, Calvez, Vincent, Cambau, Emmanuelle, Carbonnelle, Etienne, Charpentier, Charlotte, Chevaliez, Stéphane, Decousser, Jean-Winoc, Delaugerre, Constance, Descamps, Diane, Dortet, Laurent, Doucet-Populaire, Florence, Frange, Pierre, Fourati, Slim, Gaillard, Jean-Louis, Gault, Elyanne, Herrmann, Jean-Louis, Jarlier, Vincent, Kerneis, Solen, Le Goff, Jérôme, Mainardi, Jean-Luc, Marcelin, Anne-Geneviève, Morand-Joubert, Laurence, Pawlotsky, Jean-Michel, Poyart, Claire, Rameix-Welti, Marie-Anne, Robert, Jérôme, Rodriguez, Christophe, Roque Afonso, Anne-Marie, Rottman, Martin, Rozenberg, Flore, Ruppé, Etienne, Skurnik, David, Veziris, Nicolas, Zahar, Jean-Ralph, Barnaud, Guilene, Billard-Pomares, Typhaine, Cuzon, Gaëlle, Decré, Dominique, Doloy, Alexandra, Donay, Jean-Luc, Drieux-Rouzet, Laurence, Durand, Isabelle, Ferroni, Agnès, Fihman, Vincent, Fortineau, Nicolas, Gomart, Camille, Grall, Nathalie, Guillet-Caruba, Christelle, Jaureguy, Françoise, Lalande, Valérie, Landraud, Luce, Leflon, Véronique, Mariani, Patricia, Mihaila, Liliana, Moissenet, Didier, Noussair, Latifa, Podglajen, Isabelle, Poilane, Isabelle, Poupet, Hélène, Rondinaud, Emilie, Tardy, Valérie Sivadon, Trystram, David, Verdet, Charlotte, Vigier, Emmanuelle, Vimont-Billarant, Sophie, Amarsy, R., Granger, B., Fournier, S., Monteil, C., Trystram, D., Siorat, V., Jarlier, V., and Robert, J.

Published
2024
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2. Surging bloodstream infections and antimicrobial resistance during the first wave of COVID–19: a study in a large multihospital institution in the Paris region

Author

Arlet, Guillaume, Lefevre, Laurence Armand, Aubry, Alexandra, Belec, Laurent, Bercot, Béatrice, Bonacorsi, Stéphane, Calvez, Vincent, Cambau, Emmanuelle, Carbonnelle, Etienne, Chevaliez, Stéphane, Decousser, Jean-Winoc, Delaugerre, Constance, Descamps, Diane, Doucet-Populaire, Florence, Gaillard, Jean-Louis, Chenon, Antoine Garbarg, Gault, Elyanne, Herrmann, Jean-Louis, Jarlier, Vincent, Goff, Jérôme Le, Lucet, Jean-Christophe, Mainardi, Jean-Luc, Marcellin, Anne-Geneviève, Morand-Joubert, Laurence, Nassif, Xavier, Pawlotsky, Jean-Michel, Robert, Jérôme, Afonso, Anne-Marie Roque, Rottman, Martin, Rouzioux, Christine, Rozenberg, Flore, Simon, François, Veziris, Nicolas, Skurnik, David, Zahar, Jean-Ralph, Barnaud, Guilene, Pomares, Typhaine Billard, Cuzon, Gaëlle, Decré, Dominique, Doloy, Alexandra, Donay, Jean-Luc, Drieux-Rouzet, Laurence, Durand, Isabelle, Ferroni, Agnès, Fihman, Vincent, Fortineau, Nicolas, Gomart, Camille, Grall, Nathalie, Caruba, Christelle Guillet, Jaureguy, Françoise, Lalande, Valérie, Landraud, Luce, Leflon, Véronique, Mariani, Patricia, Mihaila, Liliana, Moissenet, Didier, Noussair, Latifa, Podglajen, Isabelle, Poilane, Isabelle, Poupet, Hélène, Rondinaud, Emilie, Tardy, Valérie Sivadon, Trystram, David, Verdet, Charlotte, Vigier, Emmanuelle, Billarant, Sophie Vimont, Amarsy, Rishma, Monteil, Catherine, Fournier, Sandra, Oliary, Juliette, Junot, Helga, Sabatier, Pierre, and Porcher, Raphaël

Published
2022
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3. Incidence of paediatric pneumococcal meningitis and emergence of new serotypes: a time-series analysis of a 16-year French national survey

Author

Adam, Marie Noelle, Agha-Mir, Ilhem, Akitani, Sylvia, Amara, Marlène, Arlet, Guillaume, Asensio, Valérie, Autret, Fanny, Baleine, Julien, Barnaud, Guilaine, Barrans, Alain, Barsotti, Katia, Basmaci, Romain, Bednarek, Nathalie, Belgaid, Abdelmalek, Benoist, Grégoire, Bertrou, Anne, Biessy, Hélène, Biran, Valérie, Blanc, Véronique, Blondel, Elodie, Bolot, Pascal, Bosi, Claude, Boyer, Sophie, Brouard, Jacques, Cartier-Riviere, Bernadette, Cascarigny, Françoise, Cattoen, Christian, Chace, Anne, Chalumeau, Martin, Chamouilli, Jean Marc, Chaplain, Chantal, Charachon, Sylvie, Charbonneau, Anne, Cheron, Mireille, Chevallier, Bertrand, Chomienne, Francis, Courouble, Gery, Danekova, Nevena, Dao-Dubremetz, Anne, Daoud, Patrick, Dauger, Stéphane, De Champs, Christophe, De Luca, Danièle, De Briel, André, Decobert, Marion, Desbois, Delphine, Despert, Véronique, Dessein, Rodrigue, Dessioux, Emmanuelle, Dieckmann, Katherine, Dommergues, Marie Aliette, Dorangeon, Elodie, Doucet-Populaire, Florence, Dubos, François, Dubourg, Grégory, Dufour, Marie Josée, Duval, Véronique, Eitenschenck, Laurence, Epaud, Ralph, Evreux, Françoise, Eyer, Didier, Eyssette-Gayraud, Stéphanie, Fabbro, Chrystèle, Faye, Albert, Ferroni, Agnes, Fos, Marie Pierre, Gallet, Serge, Garandeau, Caroline, Garrec, Hélène, Gaschignard, Jean, Gaudelus, Joel, Geniez, Laurent, Girard, Florent, Glastre, Catherine, Glatz, Isabelle, Goudeau, Alain, Gougeon Jollivet, Anne, Goumy, Pierre, Gouraud, François, Goux, Alain, Grando, Anna, Grimprel, Emmanuel, Guilluy, Olivier, Guyon, Gael, Guyot, Caroline, Haas, Hervé, Haegy-Doehring, Isabelle, Halna, Muriel, Hamdad, Farida, Haouisee, Severine, Herve, Christian, Heyman Guenais, Rachel, Hochart, Anne Cécile, Honore Bouakline, Stéphanie, Hubert, Nathalie, Jan, Didier, Javouhey, Etienne, Jeannot, Emmanuel, Jehan, Josette, Juvin, Marie Emmanuelle, Kalach, Nicolas, Khalfi, Ali, Labrune, Philippe, Lafendi, Leila, Lahrach, Hakim, Laisney, Norbert, Landragin, Danielle, Lapeyre, Fabrice, Laugel, Vincent, Launay, Elise, Lavigne, Jean Philippe, Le Bideau, Marc, Ledru, Sylvie, Lehours, Philippe, Lejri, Nejib, Lemenand, Olivier, Lorrot, Mathie, Lureau, Pierre, M'Bamba, Célestin, Macchi, Valérie, Madhi, Fouad, Marcou, Valérie, Marin, Mariane, Martha, Sandrine Anne, Martinot, Alain, Mezgueldi, Ellia, Micaelo, Maité, Milcent, Karen, Minette Brunel, Delphine, Moissenet, Didier, Moquet, Olivier, Morisot, Cyril, Moulene, Eric, Nicola, Nawal, Oulepsir, Abdelaziz, Pantalone, Leatitia, Patoz, Pierre, Pellegrino, Beatrice, Penel-Capelle, Delphine, Pierre, Marie Hélène, Pinquier, Didier, Pitsch, Aurélia, Plassart, Claire, Porcheret, Huong, Prere, Marie Françoise, Raymond, Josette, Rey, Agnes, Richardin, Florence, Roussellier, Patricia, Roux, Anne Laure, Roybet, Danielle, Sadik, Ahmed, Sarlangue, Jean, Saumureau, Simone, Savoy, Isabelle, Schneider, Jean Marc, Sebag, Olivier, Sivadon-Tardy, Valérie, Soustelle, Nicolas, Texier, Anthony, Thouvenin, Maxime, Toubiana, Julie, Tronc, Fréderic, Twizeyimana, Eterne, Vachee, Anne, Vernet-Garnier, Véronqiue, Vervel, Christine, Violette, Jérémie, Wallet, Fréderic, Warin, Laure, Yangui, Mohamed Amine, Ythier, Hubert, Zimmermann, Brigitte, Ouldali, Naim, Levy, Corinne, Varon, Emmanuelle, Bonacorsi, Stéphane, Béchet, Stéphane, Cohen, Robert, and Angoulvant, François

Published
2018
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5. Decrease of hospital- and community-acquired bloodstream infections due to Streptococcus pneumoniae and Streptococcus pyogenes during the first year of the COVID-19 pandemic: A time-series analysis in Paris region

Author

Amarsy, Rishma, primary, Fournier, Sandra, additional, Trystram, David, additional, Monteil, Catherine, additional, Raynaud, Xavier, additional, Jarlier, Vincent, additional, Robert, Jérôme, additional, Arlet, Guillaume, additional, Lefevre, LaurenceArmand, additional, Aubry, Alexandra, additional, Belec, Laurent, additional, Bercot, Béatrice, additional, Bonacorsi, Stéphane, additional, Calvez, Vincent, additional, Cambau, Emmanuelle, additional, Carbonnelle, Etienne, additional, Chevaliez, Stéphane, additional, Decousser, Jean-Winoc, additional, Delaugerre, Constance, additional, Descamps, Diane, additional, Doucet-Populaire, Florence, additional, Gaillard, Jean-Louis, additional, Garbarg-Chenon, Antoine, additional, Gault, Elyanne, additional, Herrmann, Jean-Louis, additional, Le Goff, Jérôme, additional, Lucet, Jean-Christophe, additional, Mainardi, Jean-Luc, additional, Marcellin, Anne-Geneviève, additional, Morand-Joubert, Laurence, additional, Nassif, Xavier, additional, Pawlotsky, Jean-Michel, additional, Afonso, Anne-Marie Roque, additional, Rottman, Martin, additional, Rouzioux, Christine, additional, Rozenberg, Flore, additional, Simon, François, additional, Veziris, Nicolas, additional, Skurnik, David, additional, Zahar, Jean-Ralph, additional, Barnaud, Guilene, additional, Pomares, Typhaine Billard, additional, Cuzon, Gaëlle, additional, Decré, Dominique, additional, Doloy, Alexandra, additional, Donay, Jean-Luc, additional, Drieux-Rouzet, Laurence, additional, Durand, Isabelle, additional, Ferroni, Agnès, additional, Fihman, Vincent, additional, Fortineau, Nicolas, additional, Gomart, Camille, additional, Grall, Nathalie, additional, Caruba, Christelle Guillet, additional, Jaureguy, Françoise, additional, Lalande, Valérie, additional, Landraud, Luce, additional, Leflon, Véronique, additional, Mariani, Patricia, additional, Mihaila, Liliana, additional, Moissenet, Didier, additional, Noussair, Latifa, additional, Podglajen, Isabelle, additional, Poilane, Isabelle, additional, Poupet, Hélène, additional, Rondinaud, Emilie, additional, Tardy, Valérie Sivadon, additional, Verdet, Charlotte, additional, Vigier, Emmanuelle, additional, and Billarant, Sophie Vimont, additional

Published
2022
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6. Surging bloodstream infections and antimicrobial resistance during the first wave of COVID–19: a study in a large multihospital institution in the Paris region

Author

Amarsy, Rishma, primary, Trystram, David, additional, Cambau, Emmanuelle, additional, Monteil, Catherine, additional, Fournier, Sandra, additional, Oliary, Juliette, additional, Junot, Helga, additional, Sabatier, Pierre, additional, Porcher, Raphaël, additional, Robert, Jérôme, additional, Jarlier, Vincent, additional, Arlet, Guillaume, additional, Lefevre, Laurence Armand, additional, Aubry, Alexandra, additional, Belec, Laurent, additional, Bercot, Béatrice, additional, Bonacorsi, Stéphane, additional, Calvez, Vincent, additional, Carbonnelle, Etienne, additional, Chevaliez, Stéphane, additional, Decousser, Jean-Winoc, additional, Delaugerre, Constance, additional, Descamps, Diane, additional, Doucet-Populaire, Florence, additional, Gaillard, Jean-Louis, additional, Chenon, Antoine Garbarg-, additional, Gault, Elyanne, additional, Herrmann, Jean-Louis, additional, Goff, Jérôme Le, additional, Lucet, Jean-Christophe, additional, Mainardi, Jean-Luc, additional, Marcellin, Anne-Geneviève, additional, Morand-Joubert, Laurence, additional, Nassif, Xavier, additional, Pawlotsky, Jean-Michel, additional, Afonso, Anne-Marie Roque, additional, Rottman, Martin, additional, Rouzioux, Christine, additional, Rozenberg, Flore, additional, Simon, François, additional, Veziris, Nicolas, additional, Skurnik, David, additional, Zahar, Jean-Ralph, additional, Barnaud, Guilene, additional, Pomares, Typhaine Billard, additional, Cuzon, Gaëlle, additional, Decré, Dominique, additional, Doloy, Alexandra, additional, Donay, Jean-Luc, additional, Drieux-Rouzet, Laurence, additional, Durand, Isabelle, additional, Ferroni, Agnès, additional, Fihman, Vincent, additional, Fortineau, Nicolas, additional, Gomart, Camille, additional, Grall, Nathalie, additional, Caruba, Christelle Guillet, additional, Jaureguy, Françoise, additional, Lalande, Valérie, additional, Landraud, Luce, additional, Leflon, Véronique, additional, Mariani, Patricia, additional, Mihaila, Liliana, additional, Moissenet, Didier, additional, Noussair, Latifa, additional, Podglajen, Isabelle, additional, Poilane, Isabelle, additional, Poupet, Hélène, additional, Rondinaud, Emilie, additional, Tardy, Valérie Sivadon, additional, Verdet, Charlotte, additional, Vigier, Emmanuelle, additional, and Billarant, Sophie Vimont, additional

Published
2022
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8. Longitudinal survey of Staphylococcus aureus in cystic fibrosis patients using a multiple-locus variable-number of tandem-repeats analysis method

Author

Vergnaud Gilles, Moissenet Didier, Corvol Harriet, Fauroux Brigitte, Corbineau Gaëlle, Hormigos Katia, Vu-Thien Hoang, and Pourcel Christine

Subjects
Microbiology, QR1-502
Abstract

Abstract Background Staphylococcus aureus infection in patients with cystic fibrosis (CF) is frequent and may be due to colonization by a few pathogenic lineages. Systematic genotyping of all isolates, methicillin-susceptible S. aureus (MSSA) as well as methicillin-resistant S. aureus (MRSA) is necessary to identify such lineages and follow their evolution in patients. Multiple-locus variable-number tandem repeat analysis (MLVA/VNTR) was used to survey S. aureus clinical isolates in a French paediatric CF centre. Results During a 30 months period, 108 patients, aged 2 to 21 years, regularly followed up at the centre, provided sputum for culture. From 79 patients, a total of 278 isolates were genotyped by MLVA, resolving into 110 genotypes and 19 clonal complexes (CC) composed of similar or closely related isolates. 71% of the strains were distributed into four main CCs, in term of number of isolates and number of genotypes. Spa (Staphylococcus protein A) typing was performed on representative samples, showing an excellent concordance with MLVA. In 17 patients, strains from two to four different CCs were recovered over time. On six occasions, S. aureus isolates with the same genotype were shared by 2 different patients and they belonged to one of the four main clusters. Methicillin-resistance was observed in 60% of the isolates, 90% of which belonged to the main clonal complexes CC8, CC45 and CC5. In 5 patients, methicillin-resistance of S. aureus isolates was not associated with the mecA gene: for four patients, it was due to overproduction of β-lactamase, leading to BOR-SA (borderline S. aureus) isolates, while a strain showing probably a new modified penicillin-binding capacity (MOD-SA) was observed from one patient. Conclusion Systematic genotyping of S. aureus isolates recovered from sputum of CF children allows a thorough analysis of the strains responsible for sporadic as well as chronic colonization and the follow up of their evolution over time. We show here that more than 70% of these strains belong to 4 major CCs. MSSA as well as MRSA, BOR-SA and MOD-SA isolates can persist over several years, despite antibiotic treatments.

Published
2010
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9. CHAC1 Is Differentially Expressed in Normal and Cystic Fibrosis Bronchial Epithelial Cells and Regulates the Inflammatory Response Induced by Pseudomonas aeruginosa

Author

Perra, Léa, primary, Balloy, Viviane, additional, Foussignière, Tobias, additional, Moissenet, Didier, additional, Petat, Hortense, additional, Mungrue, Imran N., additional, Touqui, Lhousseine, additional, Corvol, Harriet, additional, Chignard, Michel, additional, and Guillot, Loic, additional

Published
2018
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10. Incidence of paediatric pneumococcal meningitis and emergence of new serotypes: a time-series analysis of a 16-year French national survey

Author

Ouldali, Naim, primary, Levy, Corinne, additional, Varon, Emmanuelle, additional, Bonacorsi, Stéphane, additional, Béchet, Stéphane, additional, Cohen, Robert, additional, Angoulvant, François, additional, Adam, Marie Noelle, additional, Agha-Mir, Ilhem, additional, Akitani, Sylvia, additional, Amara, Marlène, additional, Arlet, Guillaume, additional, Asensio, Valérie, additional, Autret, Fanny, additional, Baleine, Julien, additional, Barnaud, Guilaine, additional, Barrans, Alain, additional, Barsotti, Katia, additional, Basmaci, Romain, additional, Bednarek, Nathalie, additional, Belgaid, Abdelmalek, additional, Benoist, Grégoire, additional, Bertrou, Anne, additional, Biessy, Hélène, additional, Biran, Valérie, additional, Blanc, Véronique, additional, Blondel, Elodie, additional, Bolot, Pascal, additional, Bosi, Claude, additional, Boyer, Sophie, additional, Brouard, Jacques, additional, Cartier-Riviere, Bernadette, additional, Cascarigny, Françoise, additional, Cattoen, Christian, additional, Chace, Anne, additional, Chalumeau, Martin, additional, Chamouilli, Jean Marc, additional, Chaplain, Chantal, additional, Charachon, Sylvie, additional, Charbonneau, Anne, additional, Cheron, Mireille, additional, Chevallier, Bertrand, additional, Chomienne, Francis, additional, Courouble, Gery, additional, Danekova, Nevena, additional, Dao-Dubremetz, Anne, additional, Daoud, Patrick, additional, Dauger, Stéphane, additional, De Champs, Christophe, additional, De Luca, Danièle, additional, De Briel, André, additional, Decobert, Marion, additional, Desbois, Delphine, additional, Despert, Véronique, additional, Dessein, Rodrigue, additional, Dessioux, Emmanuelle, additional, Dieckmann, Katherine, additional, Dommergues, Marie Aliette, additional, Dorangeon, Elodie, additional, Doucet-Populaire, Florence, additional, Dubos, François, additional, Dubourg, Grégory, additional, Dufour, Marie Josée, additional, Duval, Véronique, additional, Eitenschenck, Laurence, additional, Epaud, Ralph, additional, Evreux, Françoise, additional, Eyer, Didier, additional, Eyssette-Gayraud, Stéphanie, additional, Fabbro, Chrystèle, additional, Faye, Albert, additional, Ferroni, Agnes, additional, Fos, Marie Pierre, additional, Gallet, Serge, additional, Garandeau, Caroline, additional, Garrec, Hélène, additional, Gaschignard, Jean, additional, Gaudelus, Joel, additional, Geniez, Laurent, additional, Girard, Florent, additional, Glastre, Catherine, additional, Glatz, Isabelle, additional, Goudeau, Alain, additional, Gougeon Jollivet, Anne, additional, Goumy, Pierre, additional, Gouraud, François, additional, Goux, Alain, additional, Grando, Anna, additional, Grimprel, Emmanuel, additional, Guilluy, Olivier, additional, Guyon, Gael, additional, Guyot, Caroline, additional, Haas, Hervé, additional, Haegy-Doehring, Isabelle, additional, Halna, Muriel, additional, Hamdad, Farida, additional, Haouisee, Severine, additional, Herve, Christian, additional, Heyman Guenais, Rachel, additional, Hochart, Anne Cécile, additional, Honore Bouakline, Stéphanie, additional, Hubert, Nathalie, additional, Jan, Didier, additional, Javouhey, Etienne, additional, Jeannot, Emmanuel, additional, Jehan, Josette, additional, Juvin, Marie Emmanuelle, additional, Kalach, Nicolas, additional, Khalfi, Ali, additional, Labrune, Philippe, additional, Lafendi, Leila, additional, Lahrach, Hakim, additional, Laisney, Norbert, additional, Landragin, Danielle, additional, Lapeyre, Fabrice, additional, Laugel, Vincent, additional, Launay, Elise, additional, Lavigne, Jean Philippe, additional, Le Bideau, Marc, additional, Ledru, Sylvie, additional, Lehours, Philippe, additional, Lejri, Nejib, additional, Lemenand, Olivier, additional, Lorrot, Mathie, additional, Lureau, Pierre, additional, M'Bamba, Célestin, additional, Macchi, Valérie, additional, Madhi, Fouad, additional, Marcou, Valérie, additional, Marin, Mariane, additional, Martha, Sandrine Anne, additional, Martinot, Alain, additional, Mezgueldi, Ellia, additional, Micaelo, Maité, additional, Milcent, Karen, additional, Minette Brunel, Delphine, additional, Moissenet, Didier, additional, Moquet, Olivier, additional, Morisot, Cyril, additional, Moulene, Eric, additional, Nicola, Nawal, additional, Oulepsir, Abdelaziz, additional, Pantalone, Leatitia, additional, Patoz, Pierre, additional, Pellegrino, Beatrice, additional, Penel-Capelle, Delphine, additional, Pierre, Marie Hélène, additional, Pinquier, Didier, additional, Pitsch, Aurélia, additional, Plassart, Claire, additional, Porcheret, Huong, additional, Prere, Marie Françoise, additional, Raymond, Josette, additional, Rey, Agnes, additional, Richardin, Florence, additional, Roussellier, Patricia, additional, Roux, Anne Laure, additional, Roybet, Danielle, additional, Sadik, Ahmed, additional, Sarlangue, Jean, additional, Saumureau, Simone, additional, Savoy, Isabelle, additional, Schneider, Jean Marc, additional, Sebag, Olivier, additional, Sivadon-Tardy, Valérie, additional, Soustelle, Nicolas, additional, Texier, Anthony, additional, Thouvenin, Maxime, additional, Toubiana, Julie, additional, Tronc, Fréderic, additional, Twizeyimana, Eterne, additional, Vachee, Anne, additional, Vernet-Garnier, Véronqiue, additional, Vervel, Christine, additional, Violette, Jérémie, additional, Wallet, Fréderic, additional, Warin, Laure, additional, Yangui, Mohamed Amine, additional, Ythier, Hubert, additional, and Zimmermann, Brigitte, additional

Published
2018
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11. Transfer between an Algerian and a French hospital of four multi-drug resistant bacterial strains together via a single patient

Author

Moissenet, Didier, Richard, Patrick, Granados, Maria, Mérens, Audrey, Fournier, Damien, Fines-Guyon, Marguerite, guillaume arlet, and Vu-Thien, Hoang

Subjects
Case Report, biochemical phenomena, metabolism, and nutrition
Abstract

A 5 years-old girl, seriously burnt with fire, was first hospitalized during four days in an hospital at Alger, and then transferred to our hospital at Paris. Admitted in our intensive care burns unit, she was third degree burnt on 78% of total body surface area, already treated with imipenem and vancomycin at her arrival. Clinical aggravation was rapidly observed and death occurred within 24 hours. Cultures of blood and multiple wound swabs yielded 3 multi-drug resistant bacterial strains: Acinetobacter baumannii with carbapenemase OXA-23, Pseudomonas aeruginosa serotype O11 with metallo-ß-lactamase VIM-4 and Klebsiella pneumoniae with CTX-M-15 extended-spectrum ß-lactamase. Culture of a rectal swab showed colonization by Enterococcus faecium with vanA glycopeptides resistance. Patients colonized with one or two multi-drug-resistant strains were not rare in our burns unit, especially those transferred from Algeria, but this case of a single patient harboring four multi-drug-resistant strains is exceptional.

Published
2015

14. Ralstonia paucula (Formerly CDC Group IV c-2): Unsuccessful Strain Differentiation with PCR-Based Methods, Study of the 16S-23S Spacer of the rRNA Operon, and Comparison with Other Ralstonia Species (R. eutropha, R. pickettii, R. gilardii, and R. solanacearum)

Author

Moissenet, Didier, Bidet, Philippe, Garbarg-Chenon, Antoine, Arlet, Guillaume, and Vu-Thien, Hoang

Subjects
Base Sequence, Molecular Sequence Data, food and beverages, Betaproteobacteria, Bacteriology, Polymerase Chain Reaction, Ribotyping, Bacterial Typing Techniques, RNA, Ribosomal, 23S, RNA, Ribosomal, 16S, DNA, Ribosomal Spacer, Humans, Nucleic Acid Conformation, Cupriavidus necator, rRNA Operon, Gram-Negative Bacterial Infections, Polymorphism, Restriction Fragment Length
Abstract

Ralstonia paucula (formerly CDC group IV c-2) can cause serious human infections. Confronted in 1995 with five cases of nosocomial bacteremia, we found that pulsed-field gel electrophoresis could not distinguish between the isolates and that randomly amplified polymorphic DNA analysis was poorly discriminatory. In this study, we used PCR-ribotyping and PCR-restriction fragment length polymorphism analysis of the spacer 16S-23S ribosomal DNA (rDNA); both methods were unable to differentiate R. paucula isolates. Eighteen strains belonging to other Ralstonia species (one R. eutropha strain, six R. pickettii strains, three R. solanacearum strains, and eight R. gilardii strains) were also tested by PCR-ribotyping, which failed to distinguish between the four species. The 16S-23S rDNA intergenic spacer of R. paucula contains the tRNA(Ile) and tRNA(Ala) genes, which are identical to genes described for R. pickettii and R. solanacearum.

Published
2001

17. Meningitis Caused by Escherichia coli Producing TEM-52 Extended-Spectrum β-Lactamase within an Extensive Outbreak in a Neonatal Ward: Epidemiological Investigation and Characterization of the Strain

Author

Moissenet, Didier, primary, Salauze, Béatrice, additional, Clermont, Olivier, additional, Bingen, Edouard, additional, Arlet, Guillaume, additional, Denamur, Erick, additional, Mérens, Audrey, additional, Mitanchez, Delphine, additional, and Vu-Thien, Hoang, additional

Published
2010
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19. Temporal Dynamics of Interferon Gamma Responses in Children Evaluated for Tuberculosis

Author

Herrmann, Jean-Louis, primary, Belloy, Marie, additional, Porcher, Raphael, additional, Simonney, Nancy, additional, Aboutaam, Rola, additional, Lebourgeois, Muriel, additional, Gaudelus, Joel, additional, De LosAngeles, Laure, additional, Chadelat, Katarina, additional, Scheinmann, Pierre, additional, Beydon, Nicole, additional, Fauroux, Brigitte, additional, Bingen, Martine, additional, Terki, Mustapha, additional, Barraud, Dominique, additional, Cruaud, Philippe, additional, Offredo, Catherine, additional, Ferroni, Agnes, additional, Berche, Patrick, additional, Moissenet, Didier, additional, Vuthien, Hoang, additional, Doit, Catherine, additional, Bingen, Edouard, additional, and Lagrange, Philippe Henri, additional

Published
2009
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26. Longitudinal survey of Staphylococcus aureus in cystic fibrosis patients using a multiple-locus variable-number of tandem-repeats analysis method.

Author

Hoang Vu-Thien, Hormigos, Katia, Corbineau, Gaëlle, Fauroux, Brigitte, Corvol, Harriet, Moissenet, Didier, Vergnaud, Gilles, and Pourcel, Christine

Subjects
STAPHYLOCOCCUS aureus, CYSTIC fibrosis, STAPHYLOCOCCUS aureus infections, METHICILLIN-resistant staphylococcus aureus, LOCUS (Genetics), METHICILLIN resistance, PATIENTS
Abstract

Background: Staphylococcus aureus infection in patients with cystic fibrosis (CF) is frequent and may be due to colonization by a few pathogenic lineages. Systematic genotyping of all isolates, methicillin-susceptible S. aureus (MSSA) as well as methicillin-resistant S. aureus (MRSA) is necessary to identify such lineages and follow their evolution in patients. Multiple-locus variable-number tandem repeat analysis (MLVA/VNTR) was used to survey S. aureus clinical isolates in a French paediatric CF centre. Results: During a 30 months period, 108 patients, aged 2 to 21 years, regularly followed up at the centre, provided sputum for culture. From 79 patients, a total of 278 isolates were genotyped by MLVA, resolving into 110 genotypes and 19 clonal complexes (CC) composed of similar or closely related isolates. 71% of the strains were distributed into four main CCs, in term of number of isolates and number of genotypes. Spa (Staphylococcus protein A) typing was performed on representative samples, showing an excellent concordance with MLVA. In 17 patients, strains from two to four different CCs were recovered over time. On six occasions, S. aureus isolates with the same genotype were shared by 2 different patients and they belonged to one of the four main clusters. Methicillin-resistance was observed in 60% of the isolates, 90% of which belonged to the main clonal complexes CC8, CC45 and CC5. In 5 patients, methicillin-resistance of S. aureus isolates was not associated with the mecA gene: for four patients, it was due to overproduction of β-lactamase, leading to BOR-SA (borderline S. aureus) isolates, while a strain showing probably a new modified penicillin-binding capacity (MOD-SA) was observed from one patient. Conclusion: Systematic genotyping of S. aureus isolates recovered from sputum of CF children allows a thorough analysis of the strains responsible for sporadic as well as chronic colonization and the follow up of their evolution over time. We show here that more than 70% of these strains belong to 4 major CCs. MSSA as well as MRSA, BORSA and MOD-SA isolates can persist over several years, despite antibiotic treatments. [ABSTRACT FROM AUTHOR]

Published
2010
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27. Persistent Bloodstream Infection with Kocuria rhizophilaRelated to a Damaged Central Catheter

Author

Moissenet, Didier, Becker, Karsten, Mérens, Audrey, Ferroni, Agnès, Dubern, Béatrice, and Vu-Thien, Hoang

Abstract

ABSTRACTA case of persistent bloodstream infection with Kocuria rhizophilarelated to a damaged central venous catheter in a 3-year-old girl with Hirschsprung's disease is reported. The strain was identified as K. rhizophilaby 16S rRNA gene sequencing and matrix-assisted laser desorption ionization–time of flight mass spectrometry. Arbitrarily primed PCR analysis showed a clonal strain. The repeated septic episodes were resolved with the catheter repair.

Published
2012
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28. Meningitis Caused by Escherichia coliProducing TEM-52 Extended-Spectrum ß-Lactamase within an Extensive Outbreak in a Neonatal Ward: Epidemiological Investigation and Characterization of the Strain

Author

Moissenet, Didier, Salauze, Be´atrice, Clermont, Olivier, Bingen, Edouard, Arlet, Guillaume, Denamur, Erick, Me´rens, Audrey, Mitanchez, Delphine, and Vu-Thien, Hoang

Abstract

ABSTRACTOutbreaks caused by Enterobacteriaceaeisolates producing extended-spectrum ß-lactamases (ESBL) in neonatal wards can be difficult to control. We report here an extensive outbreak in a neonatal ward with a case of meningitis caused by an ESBL-producing Escherichia colistrain. Between 24 March and 29 April 2009, among the 59 neonates present in the ward, 26 neonates with ESBL-producing E. colirectal colonization were detected (44%). One of the colonized neonates developed meningitis with a favorable outcome after treatment combining imipenem, gentamicin, and ciprofloxacin. Despite strict intensification of hygiene and isolation procedures for more than 1 month, ward closure to new admissions was necessary to control the outbreak. Randomly amplified polymorphic DNA and pulsed-field gel electrophoresis analysis performed on 31 isolates recovered from 26 neonates and two mother's milk samples showed a clonal strain. ESBL PCR assays indicated that the strain harbored a TEM-52 ESBL encoded by an IncI1 replicon. Phylogenetic analysis by multilocus sequence typing showed that the strain belonged to rare phylogenetic group C, which is closely related to group B1 but appears as group A by the triplex PCR phylogrouping method. The strain harbored the virulence genes fuyA, aer, and iroNand was virulent in a mouse model of septicemia. This work indicates the high potential of colonization, transmission, and virulence of some ESBL-producing E. coliclones.

Published
2010
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29. Ralstonia paucula(Formerly CDC Group IV c-2): Unsuccessful Strain Differentiation with PCR-Based Methods, Study of the 16S-23S Spacer of the rRNA Operon, and Comparison with OtherRalstoniaSpecies (R. eutropha, R. pickettii, R. gilardii, and R. solanacearum)

Author

Moissenet, Didier, Bidet, Philippe, Garbarg-Chenon, Antoine, Arlet, Guillaume, and Vu-Thien, Hoang

Abstract

ABSTRACTRalstonia paucula(formerly CDC group IV c-2) can cause serious human infections. Confronted in 1995 with five cases of nosocomial bacteremia, we found that pulsed-field gel electrophoresis could not distinguish between the isolates and that randomly amplified polymorphic DNA analysis was poorly discriminatory. In this study, we used PCR-ribotyping and PCR-restriction fragment length polymorphism analysis of the spacer 16S-23S ribosomal DNA (rDNA); both methods were unable to differentiate R. pauculaisolates. Eighteen strains belonging to other Ralstoniaspecies (one R. eutrophastrain, six R. pickettiistrains, threeR. solanacearumstrains, and eight R. gilardiistrains) were also tested by PCR-ribotyping, which failed to distinguish between the four species. The 16S-23S rDNA intergenic spacer of R. pauculacontains the tRNAIleand tRNAAlagenes, which are identical to genes described forR. pickettiiand R. solanacearum.

Published
2001
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30. CDC Group IV c-2: a New RalstoniaSpecies Close to Ralstonia eutropha

Author

Moissenet, Didier, Goujon, Christophe P., Garbarg-Chenon, Antoine, and Vu-Thien, Hoang

Abstract

ABSTRACTCDC group IV c-2, an environmental gram-negative bacillus recently proposed for inclusion in the genus Ralstonia, has been isolated in several human infections. Biochemical characterization and 16S ribosomal DNA (rDNA) sequencing with phylogenetic analysis were used to characterize eight clinical isolates and four type strains. Other typing tools, such as pulsed-field gel electrophoresis (PFGE) and randomly amplified polymorphic DNA (RAPD) analysis, were also used. PFGE typing of clinical isolates was unsuccessful because the DNA was degraded, and RAPD analysis was poorly discriminatory. In contrast, the type strains were clearly distinguished with both PFGE and RAPD analysis. All of the 16S rDNA sequences were identical. Comparison of the 16S rDNA sequences to the GenBank sequences showed that they were consistent with CDC group IV c-2 belonging to the genusRalstonia. The closest matches were obtained withRalstonia eutropha. However, four differences in 32 biochemical tests separated R. eutrophafrom CDC group IV c-2, which suggests that CDC group IV c-2 is a new species of the genusRalstonia.

Published
1999
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31. DNA Fingerprinting of Ralstonia pauculaby Infrequent-Restriction-Site PCR and Randomly Amplified Polymorphic DNA Analysis

Author

Moissenet, Didier, Vu-Thien, Hoang, Benzerara, Yahia, and Arlet, Guillaume

Abstract

ABSTRACTRalstonia paucula(formerly CDC group IV c-2) is an environmental organism that can cause serious human infections, occasionally clusters of nosocomial infections. In the present work, 26 strains of R. paucula(4 from the American Centers for Disease Control and Prevention collection, 10 from the Belgian Laboratorium voor Microbiologie [LMG] collection, and 12 French clinical isolates) were analyzed with infrequent-restriction-site PCR and randomly amplified polymorphic DNA analysis. Both techniques accurately distinguished between collection strains. Two close patterns obtained for all the French isolates suggested a clonal strain. Two LMG collection strains originating from human sources in the United States also showed patterns close to those of French isolates.

Published
2003
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33. Transfer between an Algerian and a French hospital of four multi-drug resistant bacterial strains together via a single patient.

Author

Moissenet D, Richard P, Granados M, Mérens A, Fournier D, Fines-Guyon M, Arlet G, and Vu-Thien H

Abstract

A 5 years-old girl, seriously burnt with fire, was first hospitalized during four days in an hospital at Alger, and then transferred to our hospital at Paris. Admitted in our intensive care burns unit, she was third degree burnt on 78% of total body surface area, already treated with imipenem and vancomycin at her arrival. Clinical aggravation was rapidly observed and death occurred within 24 hours. Cultures of blood and multiple wound swabs yielded 3 multi-drug resistant bacterial strains: Acinetobacter baumannii with carbapenemase OXA-23, Pseudomonas aeruginosa serotype O11 with metallo-ß-lactamase VIM-4 and Klebsiella pneumoniae with CTX-M-15 extended-spectrum ß-lactamase. Culture of a rectal swab showed colonization by Enterococcus faecium with vanA glycopeptides resistance. Patients colonized with one or two multi-drug-resistant strains were not rare in our burns unit, especially those transferred from Algeria, but this case of a single patient harboring four multi-drug-resistant strains is exceptional.

Published
2015

34. Meningitis caused by Escherichia coli producing TEM-52 extended-spectrum beta-lactamase within an extensive outbreak in a neonatal ward: epidemiological investigation and characterization of the strain.

Author

Moissenet D, Salauze B, Clermont O, Bingen E, Arlet G, Denamur E, Mérens A, Mitanchez D, and Vu-Thien H

Subjects
Electrophoresis, Gel, Pulsed-Field, Hospital Units, Humans, Infant, Newborn, Microbial Sensitivity Tests, Polymerase Chain Reaction, beta-Lactamases genetics, Disease Outbreaks, Escherichia coli drug effects, Escherichia coli genetics, Escherichia coli isolation & purification, Escherichia coli pathogenicity, Meningitis, Escherichia coli epidemiology, Meningitis, Escherichia coli microbiology, beta-Lactamases metabolism
Abstract

Outbreaks caused by Enterobacteriaceae isolates producing extended-spectrum beta-lactamases (ESBL) in neonatal wards can be difficult to control. We report here an extensive outbreak in a neonatal ward with a case of meningitis caused by an ESBL-producing Escherichia coli strain. Between 24 March and 29 April 2009, among the 59 neonates present in the ward, 26 neonates with ESBL-producing E. coli rectal colonization were detected (44%). One of the colonized neonates developed meningitis with a favorable outcome after treatment combining imipenem, gentamicin, and ciprofloxacin. Despite strict intensification of hygiene and isolation procedures for more than 1 month, ward closure to new admissions was necessary to control the outbreak. Randomly amplified polymorphic DNA and pulsed-field gel electrophoresis analysis performed on 31 isolates recovered from 26 neonates and two mother's milk samples showed a clonal strain. ESBL PCR assays indicated that the strain harbored a TEM-52 ESBL encoded by an IncI1 replicon. Phylogenetic analysis by multilocus sequence typing showed that the strain belonged to rare phylogenetic group C, which is closely related to group B1 but appears as group A by the triplex PCR phylogrouping method. The strain harbored the virulence genes fuyA, aer, and iroN and was virulent in a mouse model of septicemia. This work indicates the high potential of colonization, transmission, and virulence of some ESBL-producing E. coli clones.

Published
2010
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