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Neutralizing antibodies (NAs) are key immunological markers and are part of the humoral response of the adaptive immune system. NA assays determine the presence of functional antibodies to prevent SARS-CoV-2 infection. We performed a real-world evidence study to detect NAs that confer protection against SARS-CoV-2 after the application of five vaccines (Pfizer/BioNTech, AstraZeneca, Sinovac, Moderna, and CanSino) in the Mexican population. Side effects of COVID-19 vaccines and clinical and demographic factors associated with low immunogenicity were also evaluated. A total of 242 SARS-CoV-2-vaccinated subjects were recruited. Pfizer/BioNTech and Moderna proved the highest percentage of inhibition in a mono-vaccine scheme. Muscular pain, headache, and fatigue were the most common adverse events. None of the patients reported severe adverse events. We found an estimated contagion-free time of 207 (IQR: 182–231) and 187 (IQR: 184–189) days for Pfizer/BioNTech and CanSino in 12 cases in each group. On the basis of our results, we consider that the emerging vaccination strategy in Mexico is effective and safe.

Familial adenomatous polyposis (FAP) is an autosomal-dominant condition characterized by the presence of multiple colorectal adenomas, caused by germline variants in the adenomatous polyposis coli (APC) gene. More than 300 germline variants have been characterized. The detection of novel variants is important to understand the mechanisms of pathophysiology. We identified a novel pathogenic germline variant using next-generation sequencing (NGS) in a proband patient. The variant is a complex rearrangement (c.422+1123_532-577 del ins 423-1933_423-1687 inv) that generates a complete deletion of exon 5 of the APC gene. To study the variant in other family members, we designed an endpoint PCR method followed by Sanger sequencing. The variant was identified in the proband patient’s mother, one daughter, her brother, two cousins, a niece, and a second nephew. In patients where the variant was identified, we found atypical clinical symptoms, including mandibular, ovarian, breast, pancreatic, and gastric cancer. Genetic counseling and cancer prevention strategies were provided for the family. According to the American College of Medical Genetics (ACMG) guidelines, this novel variant is considered a PVS1 variant (very strong evidence of pathogenicity), and it can be useful in association with clinical data for early surveillance and suitable treatment.

We studied the use of the library Microsoft Parallel Extensions to .NET Framework 3.5 for parallel calculations. We have developed a hierarchy of nesting classes having complicated internal structure and have made the bench tests (with graphic user interface (GUI)) not only for simple static cases but also for complex dynamic types. Our tests have shown high speedup of the library. The use of other libraries allowing calculations in parallel for various cross-platform applications is discussed also.

Estudiamos numéricamente el control del espectro de frecuencias de nano-emisores puestos en una micro-esfera recubiertas con una pila cuasi periódica. Se investiga la evolución espectral de transmisión con el cambio de espesor de bloques de dos capas, construidos siguiendo la secuencia de Fibonacci. Encontrado básicamente un comportamiento no lineal en dicho sistema: cuando el número de capas (el orden de Fibonacci) aumenta, la estructura del espectro de transmisión adquiere una forma fractal. Nuestros cálculos muestran el confinamiento y una mejora gigantesca del campo, cuando la relación entre el ancho de las capas en la pila (parámetro de control) está cerca del valor de la regla de oro. Se discute también la necesidad de un código de programación estructura orientada a objetos, para el estudio numérico de tal sistema no lineal.

Recién nombrado ministro de Justicia, Benito Juárez decretó el 23 de noviembre de 1855, la promulgación de “La ley Juárez”, la que desató una serie de opiniones en favor y en contra. Estas últimas surgidas en un principio, al frente de los sectores afectados: la Iglesia, el ejército y la Suprema Corte de Justicia, ya que esta ley contaba en su esencia con tres puntos de importancia política: la supresión de fueros, la organización de la Suprema Corte y la creación del Tribunal Superior del Distrito Federal. La controversia rebasó los límites de su tiempo, que incluyó desde la fuerte discusión dentro de la otrora clase política y de los periódicos de la época, hasta la generación de opiniones de parte de los estudiosos posteriores; simpatizantes y detractores.