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Abstract Nanoparticle-mediated drug delivery offers a promising approach to targeted cancer therapy, leveraging the ability of nanoparticles to deliver therapeutic agents directly to cancerous tissues with minimal impact on surrounding healthy cells. The presence of these nanoparticles is governed by a concentration equation, which accounts for the diffusion, convection, and reaction of the nanoparticles with the blood components. It is well-known that whenever a disease or infection occurs in a human, in 80% of cases a rise in the concentration of hydrogen peroxide in the blood occurs. This is the reason why blood is assumed to contain hydrogen peroxide (in the present study), which is a biomarker of oxidative stress and inflammation. This study explores the integration of machine learning (ML) techniques into the optimization of drug delivery processes within the human cardiovascular system, focusing on the enhancement of these processes through the application of magnetic fields. By employing ML algorithms, we analyze and predict the behavior of nanoparticles as they navigate the complex fluid dynamics of the cardiovascular system, particularly under the influence of an external magnetic field. The predictive power of ML models enables the precise control of nanoparticle trajectories, optimizing their accumulation in cancerous tissues and improving the efficacy of the drug delivery system. The findings of this study demonstrate that ML-enhanced magnetic targeting can significantly enhance the precision and effectiveness of nanoparticle-mediated drug delivery, offering a new paradigm in cancer treatment strategies. This approach has the potential to revolutionize the field by providing personalized and highly efficient therapeutic solutions for cancer patients.

Significance: The thermal analysis of nanofluid in a vertical cylinder (artery) in a magnetized environment holds significant implications in physiological and thermal regulation networks. This research is significant in biomedical engineering with applications like medical diagnostics and treatment strategies. Motive: This study investigates the thermal behavior of a magnetized blood-based ternary Carreau nanofluid flowing through a vertically bounded artery with quadratic convection. Velocity and heat transfer analysis is conducted within the artery, utilizing thermal radiation and quadratic convection in a magnetized setting. The base fluid consists of blood, augmented with three nanoparticles: CuO, Al2O3, and TiO2. The investigation centers on examining the properties of blood nanofluid, arterial geometry, and thermal dynamics. Methodology: The physical model generates a set of partial differential equations (PDEs) and similarities mechanism is utilized to fetch its non dimensional form in terms of ordinary differential equations (ODEs). Furthermore, numerical outcomes are obtained with Matlab function bvp4c and obtained data set is trained through robust scheme Levenberg-Marquardt neural network (LMNN) procedure to predict the solution. Findings: Velocity of blood is reduced with increased values of wiessenberg number, magnetic parameter and mixed convection parameter and velocity increases for Second-order convection parameter. Temperature profile decreases with curvature parameter, mixed convection parameter and permeability parameter.

In this article, we examine the optical soliton solutions of the 4th-order nonlinear Boussinesq water wave equation using the modified (G′/G2)− expansion and F-expansion methods. We utilize the similarity transformation to transform the partial differential form of the equation into an ordinary differential form. These techniques present a variety of solutions, including bright, dark, singular, dark-periodic, and singular-periodic soliton solutions. We plot the derived solutions in several profiles, such as 2D, 3D, and contour, to illustrate their physical appearance. The determined findings might be useful and have an enormous effect on the research of nonlinear phenomena in a variety of physical areas of science, like shallow water waves, acoustics, fluid dynamics, laser optics, communication systems, and heat transfer. The achieved results demonstrate the validity, applicability, and effectiveness of the presented method. We plot and validate the found solutions using the computational program MATHEMATICA.

This study introduces a novel, iterative algorithm that achieves fourth-order convergence for solving nonlinear equations. Satisfying the Kung–Traub conjecture, the proposed technique achieves an optimal order of four with an efficiency index (I) of 1.587, requiring three function evaluations. An analysis of convergence is presented to show the optimal fourth-order convergence. To verify the theoretical results, in-depth numerical comparisons are presented for both real and complex domains. The proposed algorithm is specifically examined on a variety of polynomial functions, and it is shown by the efficient and accurate results that it outperforms many existing algorithms in terms of speed and accuracy. The study not only explores the proposed method’s convergence properties, computational efficiency, and stability but also introduces a novel perspective by considering the count of black points as an indicator of a method’s divergence. By analyzing the mean number of iterations necessary for methods to converge within a cycle and measuring CPU time in seconds, this research provides a holistic assessment of both the efficiency and speed of iterative methods. Notably, the analysis of basins of attraction illustrates that our proposed method has larger sets of initial points that yield convergence.

This study focuses on the mathematical and physical analysis of a truncated M-fractional (2+1)-dimensional nonlinear Kadomtsev–Petviashvili-modified equal-width model. The distinct types of the exact wave solitons of an important real-world equation called the truncated M-fractional (2+1)-dimensional nonlinear Kadomtsev–Petviashvili-modified equal-width (KP-mEW) model are achieved. This model is used to explain ocean waves, matter-wave pulses, waves in ferromagnetic media, and long-wavelength water waves. The diverse patterns of waves on the oceans are yielded by the Kadomtsev–Petviashvili-modified equal-width (KP-mEW) equation. We obtain kink-, bright-, and periodic-type soliton solutions by using the expa function and modified extended tanh function methods. The solutions are more valuable than the existing results due to the use of a truncated M-fractional derivative. These solutions may be useful in different areas of science and engineering. The methods applied are simple and useful.

The new types of exact solitons of the space–time fractional nonlinear (4+1)-dimensional Davey–Stewartson–Kadomtsev–Petviashvili (DSKP) model are achieved by applying the unified technique and modified extended tanh-expansion function technique. A novel definition of the fractional derivative known as the truncated M-fractional derivative is also used. This model describes both the non-elastic and elastic interactions between internal waves. This model is used to represent intricate nonlinear phenomena like shallow-water waves, plasma physics, and others. The obtained results are in the form of kink, singular, bright, periodic, and dark solitons. The observed results are verified and represented by 2D and 3D graphs. The observed results are not present in the literature due to the use of fractional derivatives. The impact of the truncated M-fractional derivative on the observed results is also represented by graphs. Hence, our observed results are fruitful for the future study of these models. The applied techniques are simple, fruitful, and reliable in solving the other models in applied mathematics.

A new class of truncated M-fractional exact soliton solutions for a mathematical physics model known as a truncated M-fractional (1+1)-dimensional nonlinear modified mixed-KdV model are achieved. We obtain these solutions by using a modified extended direct algebraic method. The obtained results consist of trigonometric, hyperbolic trigonometric and mixed functions. We also discuss the effect of fractional order derivative. To validate our results, we utilized the Mathematica software. Additionally, we depict some of the obtained kink, periodic, singular, and kink-singular wave solitons, using two and three dimensional graphs. The obtained results are useful in the fields of fluid dynamics, nonlinear optics, ocean engineering and others. Furthermore, these employed techniques are not only straightforward, but also highly effective when used to solve non-linear fractional partial differential equations (FPDEs).

Convexity plays a crucial role in the development of fractional integral inequalities. Many fractional integral inequalities are derived based on convexity properties and techniques. These inequalities have several applications in different fields such as optimization, mathematical modeling and signal processing. The main goal of this article is to establish a novel and generalized identity for the Caputo–Fabrizio fractional operator. With the help of this specific developed identity, we derive new fractional integral inequalities via exponential convex functions. Furthermore, we give an application to some special means.

This manuscript involves the new exact solitary wave solutions of fractional reaction-diffusion model using the exp (− φ(η))-expansion method. The spatial model of fractional form is applied in modeling super-diffusive systems in the field of engineering, biology, physics (neutron diffusion theory), ecology, finance, and chemistry. The findings of miscellaneous studies showed that presented method is efficient for exploring new exact solutions to solve the complexities arising in mathematical physics and applied sciences. The new solutions which are obtained in the form of the rational, exponential, hyperbolic and trigonometric functions have a wide range in physics and engineering fields. Several results would be obtained under various parameters which shows good agreement with the previous published results of different papers. The proposed method can be extended to solve further problems arising in the engineering fields. My main contribution is programming and comparisons.

We developed a new family of optimal eighth-order derivative-free iterative methods for finding simple roots of nonlinear equations based on King’s scheme and Lagrange interpolation. By incorporating four self-accelerating parameters and a weight function in a single variable, we extend the proposed family to an efficient iterative scheme with memory. Without performing additional functional evaluations, the order of convergence is boosted from 8 to 15.51560, and the efficiency index is raised from 1.6817 to 1.9847. To compare the performance of the proposed and existing schemes, some real-world problems are selected, such as the eigenvalue problem, continuous stirred-tank reactor problem, and energy distribution for Planck’s radiation. The stability and regions of convergence of the proposed iterative schemes are investigated through graphical tools, such as 2D symmetric basins of attractions for the case of memory-based schemes and 3D stereographic projections in the case of schemes without memory. The stability analysis demonstrates that our newly developed schemes have wider symmetric regions of convergence than the existing schemes in their respective domains.

Abstract We investigate some solitary wave results of time fractional evolution equations. By employing the extended rational exp ( ( − ψ ′ ψ ) ( η ) ) $\exp ( (-\frac{{\psi }^{\prime }}{\psi }) ( \eta ) )$ -expansion method, a few different results including kink, singular-kink, multiple soliton, and periodic wave solutions are formally generated. It is worth mentioning that the solutions obtained are more general with more parameters. The exact solutions are constructed in the form of exponential, trigonometric, rational, and hyperbolic functions. With the choice of proper values of parameters, graphs to some of the obtained solutions are drawn. On comparing some special cases, our solutions are in good agreement with the results published previously and the remaining are new.

In this manuscript, we present a new general family of optimal iterative methods for finding multiple roots of nonlinear equations with known multiplicity using weight functions. An extensive convergence analysis is presented to verify the optimal eighth order convergence of the new family. Some special cases of the family are also presented which require only three functions and one derivative evaluation at each iteration to reach optimal eighth order convergence. A variety of numerical test functions along with some real-world problems such as beam designing model and Van der Waals’ equation of state are presented to ensure that the newly developed family efficiently competes with the other existing methods. The dynamical analysis of the proposed methods is also presented to validate the theoretical results by using graphical tools, termed as the basins of attraction.

In this paper, we present the preliminaries of ( p , q ) -calculus for functions of two variables. Furthermore, we prove some new Hermite-Hadamard integral-type inequalities for convex functions on coordinates over [ a , b ] × [ c , d ] by using the ( p , q ) -calculus of the functions of two variables. Furthermore, we establish an identity for the right-hand side of the Hermite-Hadamard-type inequalities on coordinates that is proven by using the ( p , q ) -calculus of the functions of two variables. Finally, we use the new identity to prove some trapezoidal-type inequalities with the assumptions of convexity and quasi-convexity on coordinates of the absolute values of the partial derivatives defined in the ( p , q ) -calculus of the functions of two variables.

Finding a simple root for a nonlinear equation f ( x ) = 0 , f : I ⊆ R → R has always been of much interest due to its wide applications in many fields of science and engineering. Newton’s method is usually applied to solve this kind of problems. In this paper, for such problems, we present a family of optimal derivative-free root finding methods of arbitrary high order based on inverse interpolation and modify it by using a transformation of first order derivative. Convergence analysis of the modified methods confirms that the optimal order of convergence is preserved according to the Kung-Traub conjecture. To examine the effectiveness and significance of the newly developed methods numerically, several nonlinear equations including the van der Waals equation are tested.

Solving systems of nonlinear equations plays a major role in engineering problems. We present a new family of optimal fourth-order Jarratt-type methods for solving nonlinear equations and extend these methods to solve system of nonlinear equations. Convergence analysis is given for both cases to show that the order of the new methods is four. Cost of computations, numerical tests, and basins of attraction are presented which illustrate the new methods as better alternates to previous methods. We also give an application of the proposed methods to well-known Burger's equation.

We construct a new general class of derivative free n-point iterative methods of optimal order of convergence 2n-1 using rational interpolant. The special cases of this class are obtained. These methods do not need Newton’s iterate in the …first step of their iterative schemes. Numerical computations are presented to show that the new methods are efficient and can be seen as better alternates.