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1. Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation

Author

Neyazi, Sina, Yamazawa, Erika, Hack, Karoline, Tanaka, Shota, Nagae, Genta, Kresbach, Catena, Umeda, Takayoshi, Eckhardt, Alicia, Tatsuno, Kenji, Pohl, Lara, Hana, Taijun, Bockmayr, Michael, Kim, Phyo, Dorostkar, Mario M., Takami, Toshihiro, Obrecht, Denise, Takai, Keisuke, Suwala, Abigail K., Komori, Takashi, Godbole, Shweta, Wefers, Annika K., Otani, Ryohei, Neumann, Julia E., Higuchi, Fumi, Schweizer, Leonille, Nakanishi, Yuta, Monoranu, Camelia-Maria, Takami, Hirokazu, Engertsberger, Lara, Yamada, Keisuke, Ruf, Viktoria, Nomura, Masashi, Mohme, Theresa, Mukasa, Akitake, Herms, Jochen, Takayanagi, Shunsaku, Mynarek, Martin, Matsuura, Reiko, Lamszus, Katrin, Ishii, Kazuhiko, Kluwe, Lan, Imai, Hideaki, von Deimling, Andreas, Koike, Tsukasa, Benesch, Martin, Kushihara, Yoshihiro, Snuderl, Matija, Nambu, Shohei, Frank, Stephan, Omura, Takaki, Hagel, Christian, Kugasawa, Kazuha, Mautner, Viktor F., Ichimura, Koichi, Rutkowski, Stefan, Aburatani, Hiroyuki, Saito, Nobuhito, and Schüller, Ulrich

Published
2024
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5. Preoperative angiographic considerations and neurological outcome after surgical treatment of intradural spinal hemangioblastoma: a multicenter retrospective case series

Author

Butenschoen, Vicki M., primary, Schwendner, Maximilian, additional, Hubertus, Vanessa, additional, Onken, Julia, additional, Koegl, Nikolaus, additional, Mohme, Theresa, additional, Maurer, Stefanie, additional, Boeckh-Behrens, Tobias, additional, Eicker, Sven O., additional, Thomé, Claudius, additional, Vajkoczy, Peter, additional, Czabanka, Marcus, additional, Meyer, Bernhard, additional, and Wostrack, Maria, additional

Published
2022
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6. EPEN-06. Comprehensive profiling of myxopapillary ependymomas identifies a distinct molecular subtype with relapsing disease

Author

Bockmayr, Michael, primary, Harnisch, Kim, additional, Pohl, Lara, additional, Schweizer, Leonille, additional, Mohme, Theresa, additional, Körner, Meik, additional, Alawi, Malik, additional, Suwala, Abigail, additional, Dorostkar, Mario, additional, Monoranu, Camelia, additional, Hasselblatt, Martin, additional, Wefers, Annika, additional, Capper, David, additional, Hench, Jürgen, additional, Frank, Stephan, additional, Richardson, Timothy, additional, Tran, Ivy, additional, Liu, Elisa, additional, Snuderl, Matija, additional, Engertsberger, Lara, additional, Benesch, Martin, additional, von Deimling, Andreas, additional, Obrecht, Denise, additional, Mynarek, Martin, additional, Rutkowski, Stefan, additional, Glatzel, Markus, additional, Neumann, Julia, additional, and Schüller, Ulrich, additional

Published
2022
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7. EPEN-27. Epigenetic dissection of spinal ependymomas (SP-EPN) separates tumors with and withoutNF2 mutation

Author

Neyazi, Sina, primary, Yamazawa, Erika, additional, Kresbach, Catena, additional, Nagae, Genta, additional, Eckhardt, Alicia, additional, Umeda, Takayoshi, additional, Pohl, Lara, additional, Tatsuno, Kenji, additional, Saygi, Ceren, additional, Hana, Taijun, additional, Alawi, Malik, additional, Kim, Phyo, additional, Dorostkar, Mario M, additional, Higuchi, Fumi, additional, Suwala, Abigail K, additional, Takami, Toshihiro, additional, Wefers, Annika, additional, Nakanishi, Yuta, additional, Schweizer, Leonille, additional, Takai, Keisuke, additional, Engertsberger, Lara, additional, Komori, Takashi, additional, Mohme, Theresa, additional, Takami, Hirokazu, additional, Mynarek, Martin, additional, Nomura, Masashi, additional, Lamszus, Karin, additional, Mukasa, Akitake, additional, Kluwe, Lan, additional, Takayanagi, Shunsaku, additional, von Deimling, Andreas, additional, Ishii, Kazuhiko, additional, Benesch, Martin, additional, Imai, Hideaki, additional, Snuderl, Matija, additional, Frank, Stephan, additional, Ichimura, Koichi, additional, Hagel, Christian, additional, Mautner, Viktor F, additional, Rutkowski, Stefan, additional, Tanaka, Shota, additional, Aburatani, Hiroyuki, additional, Nobuhito, Saito, additional, and Schüller, Ulrich, additional

Published
2022
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8. Comprehensive profiling of myxopapillary ependymomas identifies a distinct molecular subtype with relapsing disease

Author

Bockmayr, Michael, primary, Harnisch, Kim, additional, Pohl, Lara C, additional, Schweizer, Leonille, additional, Mohme, Theresa, additional, Körner, Meik, additional, Alawi, Malik, additional, Suwala, Abigail K, additional, Dorostkar, Mario M, additional, Monoranu, Camelia M, additional, Hasselblatt, Martin, additional, Wefers, Annika K, additional, Capper, David, additional, Hench, Jürgen, additional, Frank, Stephan, additional, Richardson, Timothy E, additional, Tran, Ivy, additional, Liu, Elisa, additional, Snuderl, Matija, additional, Engertsberger, Lara, additional, Benesch, Martin, additional, von Deimling, Andreas, additional, Obrecht, Denise, additional, Mynarek, Martin, additional, Rutkowski, Stefan, additional, Glatzel, Markus, additional, Neumann, Julia E, additional, and Schüller, Ulrich, additional

Published
2022
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9. PATH-34. MOLECULAR AND CLINICAL HETEROGENEITY WITHIN SPINAL EPENDYMOMAS

Author

Al-Kershi, Sina, primary, Kresbach, Catena, additional, Pohl, Lara, additional, Dorostkar, Mario M, additional, Suwala, Abigail K, additional, Wefers, Annika K, additional, Schweizer, Leonille, additional, Engertsberger, Lara, additional, Mohme, Theresa, additional, Mynarek, Martin, additional, Lamszus, Katrin, additional, Kluwe, Lan, additional, von Deimling, Andreas, additional, Benesch, Martin, additional, Hagel, Christian, additional, Mautner, Viktor, additional, Rutkowski, Stefan, additional, and Schüller, Ulrich, additional

Published
2021
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10. Cavernous Malformations and Hemangioblastomas of the Spinal Cord Show Distinct Differences in Clinical Course – A Retrospective Single-Center Analysis of 112 Patients

Author

Pantel, Tobias, Mende, Klaus Christian, Mohme, Theresa, Mohme, Malte, Viezens, Lennart, Matschke, Jakob, Westphal, Manfred, and Eicker, Sven Oliver

Abstract

Study Design Retrospective cohort study.Objective Cavernous malformations (CMs) and hemangioblastomas (HBs) of the spinal cord exhibit distinct differences in histopathology but similarities in the neurological course. The aim of our study was to analyze the clinical differences between the vascular pathologies and a benign tumor of the spinal cord in a perioperative situation.Methods We performed a retrospective analysis of patients who had undergone surgery for lesions in the spinal cord between 1984 and 2015. Patients were screened for CMs and HBs as the primary inclusion criteria. General patient information, surgical data, and disease-specific data were collected from the records. Cooper–Epstein scores for clinical symptoms were evaluated preoperatively, at discharge, and at the 6-month follow-up.Results A total of 112 patients were included, of which 46 had been diagnosed with CMs and 66 with HBs. Patients with CMs often demonstrated more preoperative neurological deterioration compared to those with HBs (P< .05); accordingly, in took longer to diagnose HBs. Complete resection was possible for 96.8% of all patients with CMs and 90% of those with HBs. At the 6-month follow-up, patients with HBs more often presented with persisting neurologic impairment of the upper extremities compared to the CM patients (P< .001).Conclusion CMs and HBs of the spinal cord have similarities but also exhibit significant differences in neurological presentation and perioperative course. Surgical therapy is the treatment of choice for symptomatic lesions, and complete surgical resection is possible in the majority of cases for both entities. Neurologic outcomes are usually favorable, although patients with HBs retain neurologic deficits more often.

Published
2024
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