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Your search keyword '"Mohiyiddeen, Lamiya"' showing total 30 results
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30 results on '"Mohiyiddeen, Lamiya"'

2. The role of FSH receptor gene polymorphisms in the prediction of ovarian response in patients undergoing in-vitro fertilization (IVF) treatment

Author

Mohiyiddeen, Lamiya, Newman, William, and Nardo, Luciano

Subjects
612.6, Single nucleitide polymorphism, SNP, FSH receptor, FSH, Ser680Asn
Abstract

Background: The ovarian response to follicle stimulating hormone (FSH) stimulation in assisted conception cycles is variable. Although it would be beneficial to predict accurately the response of patients to FSH, to date no robust predictors of ovarian performance have been identified. Recently, there have been a number of studies on the effect of single nucleotide polymorphisms (SNP) in the FSH receptor gene and its predictive value in the patients undergoing ovarian stimulation. Several reports have shown that two common SNPs at positions 307 and 680 in exon 10 of the FSH receptor gene are associated with ovarian response in in-vitro fertilization (IVF). Some authors have shown predictability of ovarian response to FSH stimulation in patients with different alleles, while others have refuted this finding. Until now, there is no clear clinical benefit in screening FSHR genotypes before IVF treatment. Objective: 1) To study the association between ovarian response and FSHR gene polymorphisms2) To study the association between FSHR gene polymorphisms and markers of ovarian reserve, including Anti Mullerian Hormone, Antral Follicle Count, Follicle Stimulating Hormone.Design: Prospective observational studyMethodology: 421 patients attending a tertiary reproductive medicine unit undergoing first cycle of IVF treatment were recruited into the study. Blood tests were taken on day 2 or 3 of the cycle for assessment of hormones and for DNA extraction. The SNP genotyping was done using Taqman analysis. Non-parametric tests were done to compare the various outcome parameters in patients with different genotypes.Results: FSHR p.Asn680Ser was not predictive of ovarian response. There was no evidence of any difference in basal FSH, AMH or AFC between the patients with different FSHR genotypes, with or without an adjustment for age or BMI. On subgroup analysis, there was no evidence that FSHR p.Asn680Ser genotypes are associated with PCOS, high AMH levels or response to clomiphene citrate. FSHR gene polymorphism was also not related to oocyte maturity or fertilization rate.Conclusions: FSHR p.Asn680Ser was not shown to be predictive of ovarian response, although clinically relevant differences cannot be ruled out. There may be an effect size but smaller than that detected for the power of this study. Other genetic markers may be relevant in the prediction of response to ovarian stimulation.

Published
2012

11. Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilisation: RCT and systematic review

Author

Metwally, Mostafa, primary, Chatters, Robin, additional, Pye, Clare, additional, Dimairo, Munya, additional, White, David, additional, Walters, Stephen, additional, Cohen, Judith, additional, Young, Tracey, additional, Cheong, Ying, additional, Laird, Susan, additional, Mohiyiddeen, Lamiya, additional, Chater, Tim, additional, Pemberton, Kirsty, additional, Turtle, Chris, additional, Hall, Jamie, additional, Taylor, Liz, additional, Brian, Kate, additional, Sizer, Anya, additional, and Hunter, Helen, additional

Published
2022
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16. A randomised controlled trial to assess the clinical effectiveness and safety of the endometrial scratch procedure prior to first-time IVF, with or without ICSI

Author

Metwally, Mostafa, primary, Chatters, Robin, additional, Dimairo, Munya, additional, Walters, Stephen, additional, Pye, Clare, additional, White, David, additional, Bhide, Priya, additional, Chater, Tim, additional, Cheong, Ying, additional, Choudhary, Meenakshi, additional, Child, Tim, additional, Drakeley, Andrew, additional, Evbuomwan, Isaac, additional, Gelbaya, Tarek, additional, Grace, Jan, additional, Harris, Philip, additional, Laird, Susan, additional, da Silva, Sarah Martins, additional, Mohiyiddeen, Lamiya, additional, Pemberton, Kirsty, additional, Raine-Fenning, Nick, additional, Rajkhowa, Madhurima, additional, Young, Tracey, additional, and Cohen, Judith, additional

Published
2021
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18. Tubal flushing for subfertility

Author

Wang, Rui, additional, Watson, Andrew, additional, Johnson, Neil, additional, Cheung, Karen, additional, Fitzgerald, Cheryl, additional, Mol, Ben Willem J, additional, and Mohiyiddeen, Lamiya, additional

Published
2020
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22. Induced endometrial trauma (endometrial scratch) in the mid-luteal menstrual cycle phase preceding first cycle IVF/ICSI versus usual IVF/ICSI therapy: study protocol for a randomised controlled trial

Author

Pye, Clare, primary, Chatters, Robin, additional, Cohen, Judith, additional, Brian, Kate, additional, Cheong, Ying C, additional, Laird, Susan, additional, Mohiyiddeen, Lamiya, additional, Skull, Jonathan, additional, Walters, Stephen, additional, Young, Tracey, additional, and Metwally, Mostafa, additional

Published
2018
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23. Tubal flushing for subfertility

Author

Mohiyiddeen, Lamiya, primary, Hardiman, Anne, additional, Fitzgerald, Cheryl, additional, Hughes, Edward, additional, Mol, Ben Willem J, additional, Johnson, Neil, additional, and Watson, Andrew, additional

Published
2015
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30. Transvaginal biopsy in the diagnosis of ovarian cancer.

Author

Faulkner RL, Mohiyiddeen L, McVey R, and Kitchener HC

Subjects
Aged, Biopsy, Needle methods, Female, Humans, Ovarian Neoplasms pathology, Ovary pathology
Abstract

Laparotomy and debulking surgery followed by chemotherapy have been the treatment of choice in late stage ovarian carcinoma. Developments in the chemotherapeutic management of ovarian cancer have resulted in a change in opinion as to the optimal management of this disease. Many patients are now receiving initial chemotherapy and trials are in place to compare up front and adjuvant surgery. Tissue diagnosis is required prior to commencing chemotherapy. This article describes one method for accurately obtaining a tumour biopsy. A retrospective case note review of 14 women with a provisional diagnosis of ovarian carcinoma who underwent transvaginal biopsy of their pelvic disease is described. Only 7/12 cases with a positive biopsy had a definite diagnosis of ovarian cancer. The procedure was found to be safe and well tolerated.

Published
2005
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