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Uterine fibroids (UFs), leiomyomas or myomas, are a type of malignancy that affects the smooth muscle of the uterus, and it is most commonly detected in women of reproductive age. Uterine fibroids are benign monoclonal growths that emerge from uterine smooth muscle cells (myometrium) as well as fibroblasts. Uterine fibroid symptoms include abnormal menstrual bleeding leading to anaemia, tiredness, chronic vaginal discharge, and pain during periods. Other symptoms include protrusion of the abdomen, pain during intercourse, dysfunctions of bladder/bowel leading to urinary incontinence/retention, pain, and constipation. It is also associated with reproductive issues like impaired fertility, conceiving complications, and adverse obstetric outcomes. It is the leading cause of gynaecological hospitalisation in the American subcontinent and a common reason for the hysterectomy. Twenty-five percent of the reproductive women experience the symptoms of uterine fibroids, and among them, around 25% require hospitalization due to the severity of the disease. The frequency of the disease remains underestimated as many women stay asymptomatic and symptoms appear gradually; therefore, the condition remains undiagnosed. The exact frequency of uterine fibroids varies depending on the diagnosis, and the population investigated; nonetheless, the incidence of uterine fibroids in reproductive women ranges from 5.4 percent to 77 percent. The uterine fibroid treatment included painkillers, supplementation with iron, vitamin D3, birth control, hormone therapy, gonadotropin-releasing hormone (GnRH) agonists, drugs modulating the estrogen receptors, and surgical removal of the fibroids. However, more research needed at the level of gene to get a keen insight and treat the disease efficiently.

Objective: To study the prescribing pattern and adverse drug reactions (ADRs) of anti-diabetic drugs in a tertiary care hospital in Lucknow, India. Methods: A prospective study was conducted over a period of 6 months at the inpatient and outpatient departments of the hospital. A total of 100 patients with diabetes were included in our study. Demographic characteristics were recorded and 100 prescriptions were analyzed. ADRs were reported and analyzed. Results: Among the 100 patients, 58 were male and 42 were female. The majority of the patients were in the age group of 41-60 years. Biguanides (38%) and sulphonylureas (31%) were the most commonly prescribed anti-diabetic drugs. A total of 8 ADRs were reported, including hypoglycemia, gastric irritation, and abdominal discomfort. Metformin had the highest number of ADRs among the oral hypoglycemic drugs. Conclusion: The study showed that the prescribing pattern of anti-diabetic drugs in the hospital was in line with the essential medicine list. ADRs were reported, with hypoglycemia being the most common ADR observed. Continuous monitoring and reporting of ADRs is necessary for the safe and effective use of anti-diabetic drugs. Keywords: Prescribing pattern, adverse drug reactions, anti-diabetic drugs, diabetes, metformin

Introduction: Severe Acute Respiratory Syndrome SARS-Cov-2 coronavirus is a member of the coronavirus family. Fever, shortness of breath, and pneumonic infiltrates in both lungs were among the disease’s clinical signs. Along with severe respiratory infections, Covid-19 may also encounter thrombosis complications, and other complications like coronary syndrome, myocardial dysfunction and arrhythmia, acute kidney injury, coronary syndrome, liver cell injury, gastrointestinal symptoms, hyperglycaemia, ocular symptoms, neurological diseases, and dermatological problems. The way in which ophthalmic services were provided changed significantly during this time. Many people, particularly those who suffer from dry eye, are spending a lot of time at home due to continuous spread of coronavirus disease (COVID-19) pandemic. The difficulty for regular follow-up meetings impacting the continuance of glaucoma therapy, cataract surgery, and other eye diseases had been considerably much worse by establishment of strict social distancing and restrictions in travelling during COVID 19 pandemic. Methods: The PubMed, Google Scholar, ResearchGate and healthcare system evidences were searched from 2019 to 2022 for systemic review that were published in English language. Results: Both ocular disease and the overall health care system have been impacted by the result of Covid 19 pandemic. Like other professions, ophthalmology profession has experienced varied degrees of pandemic impact. Ocular problems could develop as a direct result of the SARS infection. The most frequent ocular symptom is viral conjunctivitis, dry-eye problems. During lockdown, the overall symptoms of dry eyes were worse than those who were under normal circumstances. Keywords: COVID-19, Dry-Eye Disease , Eye Diseases, SARS-CoV-2

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening skin reactions, often triggered by medications such as antiepileptic drugs, nonsteroidal anti-inflammatory drugs, and certain antibiotics. Carbamazepine is one of the most common antiepileptic medicine that causes SJS. A 13-year-old male with a history of 2 years of epilepsy presented with a painful rash and extensive blistering with mucous membrane involvement, along with fever and Nilkolsky sign. Based on clinical presentation and previous medication history, the patient was diagnosed with Stevens-Johnson syndrome, and carbamazepine was identified as the cause. Carbamazepine was discontinued, and the patient was given nutritional support, wound care, and intravenous fluids, along with steroid and antihistamine treatment. The patient’s symptoms improved, and he was discharged after 13 days. Physicians must be aware of the potential for life-threatening drug hypersensitivity reactions in patients taking certain medications, particularly antiepileptic drugs. A thorough history and careful monitoring are essential for the early recognition and treatment of SJS and TEN. We want to advise all physicians that for patients with a previous drug reaction to this class of medication, carbamazepine prescribing should be avoided. KEYWORDS: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), carbamazepine (CBZ), phenytoin (PHT), ADR.

Objective: The objective of present clinical report was to highlight importance of early identification of adverse drug reactions (ADRs) in the patients who have taken dapagliflozin during the treatment of type-2 diabetes. Case presentation: A 58years old female patient having body weight 49 kg, a known case of type-2 diabetes (Since 8 years) visited the outpatient department at the tertiary care hospital on 1st June, 2022, with the complaints of uncontrolled diabetes (since 3 year) along with lower limb pain . Patient was evaluated, investigated by the consultant .After taking of medication patient started loose motion/ diarrhea 8- 10 episodes on 2nd June, 2022. The risk of developing loose motion/diarrhea while taking of dapagliflozin with certain factors such as advance age, drug- drug interaction, genetic polymorphism and gender. Conclusion: This case highlights the need of monitoring of dapagliflozin treatment in clinics and hospitals. The use of risk stratification tool to identify the risk of patients and also need for self monitoring by the patients.

Introduction: A global health issue known as antimicrobial resistance (AMR) transcends geopolitical boundaries. Surgical antibiotic prophylaxis (SAP) is the process of administering antimicrobial to treat contagions as a preventative measure, avoid them before, during, and after surgery. During surgery or after surgery there may be chances of acquiring infection. Infection at the surgical site is one such complication known as surgical site infection (SSI). It is one of the problems that reoccur the most frequently in clinical setting. Surgical site infection is described as an infection that develops with in thirty days of surgery and might be deep, affecting the organs reached during surgery, or superficial, involving only the skin. SSIs are occasionally the leading cause of death following surgical treatments. So, to reduce these types of complication we use surgical antibiotic prophylaxis. Methods: PubMed, Google Scholar, ResearchGate, and healthcare system evidence were searched from 2005 to 2022 for systemic review that was published in the English language. Result: Data were extracted for all primary outcomes, 38 reviews were included, and review quality was evaluated using AMSTAR 2. The most often reported administration of antibiotic, timing, drug class, and primary result, respectively, were preoperative antibiotic administration, first generation cephalosporin usage, and surgical site infection (SSI). Results indicate that, in comparison to a placebo or no SAP, SAP may, on average, decrease SSIs. The finding showed that postoperative SAP did not differ significantly from intraoperative SAP in reducing SSI. Keywords: Surgical Antibiotic Prophylaxis (SAP), Surgical Site Infections (SSIs), Wound Classification

Purpose- International Financial Reporting Standards (IFRS) has mustered enough attention from accountants, bankers, Multinational Companies, Government and social scientists, with many glorifying it over the antiquated financial reporting system. Despite the acceptance and all the initiatives; the execution of International Financial Reporting Standards have to encounter certain challenges, influencing its fruitful execution across developing nations. Moreover, no attempt has been made to create a conceptual framework for strengthening the existing research work. Methodology- The present research initiative underwent an in-depth review of literature pertaining to the various barriers impeding the effective execution of International Financial Reporting Standards for understanding and managing the business affairs keeping a parity between the national and global accounting aspects. Scholarly papers were reviewed from standardized and peer-reviewed journals and open sources. Almost a total of 100 papers were ascertained, published between 2001 and 2019. The data-driven qualitative content analysis and Hermeneutics were used for defining 30 barriers. Findings- The 30 barriers were thematically assorted into 4 conceptual categories, i.e. Technological Infrastructure (T), Individual, (I), Financial Constraints (F) and Supportive Environment (S). These categories formed the foundation to conceptualize the ‘TIFS’ framework that depicts the unique aspects impeding the successful execution of International Financial Reporting Standards. The findings reflect that majority of the articles only acknowledged briefing of such challenges. Practical Implications- The proposed ‘TIFS’ framework provides a way for the accountants of Multinational Companies, Strategists, Software developers, business intellectuals and experts as well as researchers. It enables the multiple stakeholders to have a bird-eye-view of the various hindrances for execution of International Financial Reporting Standards in the developing nations. Originality/Value- The paper fulfills the requisite to have a well-defined framework, which summed up the present research pertaining to barriers for execution of International Financial Reporting Standards accounting system.

Myricetin is a member of the group of flavonoids called flavonols. Myricetin is obtained from various fruit, vegetables, tea, berries and red wine. Myricetin is characterized by the pysrogallol B-ring, and the more hydroxylated structure is known to be capable for its increased biological properties compared with other flavonols. Myricetin is produced by the Myricaceae, Anacardiaceae, Polygonaceae, Pinaceae and Primulacea families. It is soluble in organic solvent such as ethanol, DMSO (dimethyl sulfoxide), and dimethyl formamide (DMF). It is sparingly soluble in aqueous buffers. Myricetin shows its various pharmacological activities including antioxidant, anti-amyloidogenic, antibacterial, antiviral, antidiabetic, anticancer, anti-inflammatory, anti-epileptic and anti-ulcer. This review article focuses on pharmacological effects of Myricetin on different diseases such as osteoporotic disorder, anti-inflammatory disorder, alzheimer’s disease, anti-epileptic, cancer, cardiac disorder, diabetic metabolic disorder, hepatoprotective disorder and gastro protective disorder.

The advancements in the field of Artificial Intelligence (AI) and technology has led to an evolution of an intelligent era. Neural networks, having the computational power and learning ability similar to the brain is one of the key AI technologies. Neuromorphic computing system (NCS) consists of the synaptic device, neuronal circuit, and neuromorphic architecture. Memristor are a promising candidate for neuromorphic computing systems, but when it comes to neuromorphic computing, the conductance behavior of the synaptic memristor or neuronal memristor needs to be studied thoroughly in order to fathom the neuroscience or computer science. Furthermore, there is a need of more simulation work for utilizing the existing device properties and providing guidance to the development of future devices for different performance requirements. Hence, development of NCS needs more simulation work to make use of existing device properties. This work aims to provide an insight to build neuronal circuits using memristors to achieve a Memristor based NCS. Here we throw a light on the research conducted in the field of memristors for building analog and digital circuits in order to motivate the research in the field of NCS by building memristor based neural circuits for advanced AI applications. This literature is a step in the direction where we describe the various Key findings about memristors and its analog and digital circuits implemented over the years which can be further utilized in implementing the neuronal circuits in the NCS. This work aims to help the electronic circuit designers to understand how the research progressed in memristors and how these findings can be used in implementing the neuronal circuits meant for the recent progress in the NCS.

Corporate social responsibility (CSR) is the responsibility recognized by the companies for acting in a socially responsible manner integrated into a business model. CSR is the commitment of the business organization for the equitable growth and sustainable development of the society. It is a management concept whereby companies integrate social and environmental concerns in their business operations and interactions with their stakeholders. CSR is generally understood as being the way through which a company achieves a balance of economic, environmental and social imperatives. In India, Public Sector Enterprises (PSE’s) play a significant role in the economic and social growth and development. They are regularly concerned about the economic and social development, employment generation, poverty eradication as well as community welfare at large. CSR practices become mandatory by every company after the implementation of Indian Companies Act, 2013 (Chapter, VI, Sec. 135). There are numbers of Indian Public Sector companies regularly works towards the economic growth of the country as well as social development. MMTC Ltd. is one of the largest public sector trading company of India which deals in trading of minerals, metals, iron ore, agro products, jems and jewellary items around the globe. The company also concern about the CSR practices as its core focus on major areas as prescribed by the Government of India. The present study is an attempt to discuss and evaluate the corporate social responsibility practices by Minerals and Metals Trading Corporation (MMTC) of India Ltd in the light of Government’s CSR policy. The study highlights the areas where the company has completed projects under CSR activities and its impact on the company’s performance during the last ten years. The study also focuses on funds allocation and their effective utilization under CSR practices by the company

Besides inciting persistent and recurrent nosocomial afflictions, Staphylococcus aureus (S. aureus), a biofilm forming pathogen, poses an increased risk of several skin as well as respiratory tract infections as well. Emerging antimicrobial resistance trend asks to search for an alternate non-antibiotic based option to combat S. aureus pathogen. In the present study, we evaluated synergistic antimicrobial potential of Zinc oxide nanorods (ZnO-NRs) and diallyl sulphide (DAS) emulsion against methicillin resistant Staphylococcus aureus (MRSA). The antimicrobial assessment study suggests that the ZnO-NR and DAS emulsion effectively suppressed both sensitive S. aureus as well as MRSA isolates. The combination treatment showed enhanced activity even at a lower concentration as compared to the single treatment based on ZnO-NRs and DAS emulsion alone. The ZnO-NRs-DAS combination showed significant inhibition of MRSA biofilm as well. The data suggest that a combination therapy, comprising of ZnO-NRs and DAS emulsion, successfully treated experimental dermatitis infection caused by MRSA in mice model.

Cement Industry play very significant role in Indian economy. It facilitates the basic infrastructure facility for the development of the country. Indian Cement industry is the second largest industry throughout the Globe only after China. The present study is an attempt to evaluate the financial performance of Cement Industry of India with special reference to Cement Corporation of India limited (CCI). The financial performance will have been evaluated through the financial ratios. Liquidity position of the company will be checked through short term solvency ratios while earning performance have been evaluated with the help of profitability ratios. Other financial and statistical tools and techniques have also been applied in order to check the overall financial position of the company.

Many diseases that were considered major affliction of mankind in the past have been successfully eradicated with introduction of appropriate vaccine strategies. In order to expedite new challenges coming up to deal with various infectious diseases, nano-particulate-based subunit vaccines seem to be the demand of ordeal. The nano-vaccines can find better scope for the diseases that were not rampant in the semi-advanced world few years back. For example in present-day circumstances that corroborate with advancement in the field of medical sciences in terms of cancer chemotherapy, organ transplantation, therapy of autoimmune diseases, etc.; along with prevalence of altogether unheard diseases such as HIV infection, people are at risk of infliction with many more pathogens. In this regard, development of an effective prophylactic strategy against many opportunistic infections primarily caused by fungal pathogens needs better understanding of host pathogen relation and role of active immunity against pathogenic fungi. In the present study, we have tried to decipher effectiveness of a nano-sized vaccine delivery system in imparting protection against fungal pathogens.

Background Type 1 diabetes mellitus is a chronic inflammatory disease involving insulin producing β-cells destroyed by the conjoined action of auto reactive T-cells, inflammatory cytokines and monocytic cells. The aim of this study was to elucidate the status of pro-inflammatory cytokines and biochemical markers and possible correlation of these factors towards outcome of the disease. Methods The study was carried out on 29 T1D subjects and 20 healthy subjects. Plasma levels of oxidative stress markers, enzymatic and non-enzymatic antioxidants were estimated employing biochemical assays. The levels of pro-inflammatory cytokines such as by IL-1β & IL-17 in the serum were determined by ELISA, while the expression of TNF-α, IL-23 & IFN-γ was ascertained by qRT-PCR. Results The onset of T1D disease was accompanied with elevation in levels of Plasma malondialdehyde, protein carbonyl content and nitric oxide while plasma vitamin C, reduced glutathione and erythrocyte sulfhydryl groups were found to be significantly decreased in T1D patients as compared to healthy control subjects. Activity of antioxidant enzymes, superoxide dismutase, catalase, glutathione reductase and glutathione-s-transferase showed a significant suppression in the erythrocytes of T1D patients as compared to healthy subjects. Nevertheless, the levels of pro-inflammatory cytokines IL-1β and IL-17A were significantly augmented (***p≤.001) on one hand, while expression of T cell based cytokines IFN-γ, TNF-α and IL-23 was also up-regulated (*p≤.05) as compared to healthy human subjects. Conclusion The level of pro-inflammatory cytokines and specific biochemical markers in the serum of the patient can be exploited as potential markers for type 1 diabetes pathogenesis. The study suggests that level of inflammatory markers is up-regulated in T1D patients in an age dependent manner.

Extensive development in portable devices imposes pressing need for designing VLSI circuits with ultralow power (ULP) consumption. Subthreshold operating region is found to be an attractive solution for achieving ultralow power. However, it limits the circuit speed due to use of parasitic leakage current as drive current. Maintaining power dissipation at ultralow level with enhanced speed will further broaden the application area of subthreshold circuits even towards the field programmable gate arrays and real-time portable domain. Operating the Si-MOSFET in subthreshold regions degrades the circuit performance in terms of speed and also increases the well-designed circuit parameter spreading due to process, voltage, and temperature variations. This may cause the subthreshold circuit failure at very low supply voltage. It is essential to examine the robustness of most emerging devices against PVT variations. Therefore, this paper investigates and compares the performance of most promising upcoming devices like CNFET and DG FinFET in subthreshold regions. Effect of PVT variation on performance of CNFET and DG FinFET has been explored and it is found that CNFET is more robust than DG-FinFET under subthreshold conditions against PVT variations.

The synthesis of a series of 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones derived from 4-oxo-4-(biphenyl-4-yl)butanoic acid (fenbufen) is described. The structures of these compounds were supported by IR, (1)H NMR, mass spectrometric data and elemental analysis. These compounds were tested for their antiinflammatory, analgesic, ulcerogenic and lipid peroxidation actions. A few compounds were found to have very good antiinflammatory activity in carrageenan induced rat paw edema test, while a fair number of compounds showed significant analgesic activity in acetic acid induced writhing test. The newly synthesized compounds showed very low ulcerogenic action with reduced malondialdehyde (MDA) content, which is one of the byproducts of lipid peroxidation. In vitro COX-1 and COX-2 isozyme inhibition studies were also performed on some of the selected compounds. Compound 4i and 4h were found to be more selective towards COX-2 as indicated by COX-2 selectivity index of 36.06 and 29.05 (COX-2 IC(50)=1.5 microM and 1.8 microM) respectively.

Synthesis and biological evaluation of various aroylpropionic acid derivatives containing 1,3,4-Oxadiazole nucleus is reported here. The compounds (3a-w) were synthesized by cyclization of 3-aroylpropionic acids into 1,3,4-oxadiazole nucleus by treating with various aryl acid hydrazides in the presence of POCl(3). The structures of new compounds are supported by IR, (1)H NMR and MS data. These compounds were tested in vivo for their anti-inflammatory activity. All the compounds tested showed anti-inflammatory activity. The compounds which showed activity comparable to the standard drug ibuprofen were screened for their analgesic, ulcerogenic and lipid peroxidation activities. Seven (3c, g, i, j, m, o, p) out of 23 new compounds showed very good anti-inflammatory activity in the carrageenan-induced rat paw edema test with very less ulcerogenic action. The compounds, which showed less ulcerogenic action, also showed reduced malondialdehyde production (MDA), which is one of the byproducts of lipid peroxidation. Compound 3i and o showed 89.50 and 88.88% of inhibition in paw edema, 69.80 and 66.25% protection against acetic acid induced writhings and 0.7 and 0.65 of severity index respectively, compared to 90.12, 72.50 and 1.95 values of ibuprofen. The study showed that the cyclization of carboxylic group of aroylpropionic acids into an oxadiazole nucleus resulted in compounds having good anti-inflammatory and analgesic effects with reduced gastric irritation.

A novel series of 1-(4-phenoxyphenyl)-3-[5-(substituted aryl)-1,3,4-oxa- diazol-2-yl]propan-1-one was synthesized by reaction of 3-(4-phenoxybenzoyl)propionic acid with several aryl acid hydrazides in phosphorus oxychloride. The structures of the compounds were supported by IR, 1H- and 13C-NMR, MS data and elemental analysis results. These compounds were tested for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation actions. A few compounds were found to have very good anti-inflammatory activity in the carrageenan-induced rat paw edema test, while a fair number of the compounds showed significant analgesic activity in the acetic acid-induced writhing test. These new compounds showed very low ulcerogenic action with reduced malondialdehyde content (MDA), which is one of the by-products of lipid peroxidation.

Aggressive voltage scaling into the subthreshold operating region holds great promise for applications with strict energy budget. However, it has been established that higher speed superthreshold device is not suitable for moderate performance subthreshold circuits. The design constraint for selectingVthandTOXis much more flexible for subthreshold circuits at low voltage level than superthreshold circuits. In order to obtain better performance from a device under subthreshold conditions, it is necessary to investigate and optimize the process and geometry parameters of a Si MOSFET at nanometer technology node. This paper calibrates the fabrication process parameters and electrical characteristics for n- and p-MOSFETs with 35 nm physical gate length. Thereafter, the calibrated device for superthreshold application is optimized for better performance under subthreshold conditions using TCAD simulation. The device simulated in this work shows 9.89% improvement in subthreshold slope and 34% advantage inION/IOFFratio for the same drive current.

Bulk CMOS technology is facing enormous challenges at channel lengths below 45 nm such as gate tunneling, device mismatch, random dopant fluctuations, mobility degradation, etc. Although multiple gate transistors and strained silicon devices overcome some of the bulk CMOS problems, it is sensible to look for revolutionary new materials and devices to replace silicon. It is obvious that future technology materials should exhibit higher mobility, better channel electrostatics, scalability, and robustness against process variations. Carbon nanotube based technology is very promising because it has most of these desired features. There is a need to explore the potential of this emerging technology by designing circuits based on this technology and comparing their performance with that of existing bulk CMOS technology for its rapid commercialization. Therefore, this paper presents a comparative study of CMOS version and CNFET version of Operational amplifier at 32-nm technology nodes. The performance of CNFET based amplifier has been thoroughly investigated in terms of its input resistance, output resistance and AC gain. This study shows that there is considerable improvement in the above feature of amplifier using CNFET. It is founded that CNFET based amplifier have 9 times AC gain, 100 times input resistance and output resistance decrease by 9 times compared to MOSFET based amplifier at 32-nm technology node. Furthermore, comparison between two technologies for same gain bandwidth product (GBP) has also been presented.

The paper presents the performance comparison of a wide bandwidth Dual-X Current Conveyor, designed using CMOS and Hybrid approaches at 32nm technology node. A hybrid configuration is obtained by utilizing both CMOS and CNFET on the same chip. CNFETs seems to be a good prospect for extending the saturating Moore's Law because of it's higher mobility, scalability and better channel electrostatics. 3-dB current bandwidth, port-resistances along with power consumption have been chosen as the key parameters for comparison. The work in this paper shows that through properly designed hybrid configuration, an edge in performance could be obtained over Si CMOS, thus making it a good proposition for ultra wideband circuits and systems.

This paper presents a study of MTJ-based logic circuit in terms of propagation delay, power dissipation, and power-delay product. The paper also analyzes impact of PVT process, voltage, and temperature) variations on most of the design metrics of logic circuit and compares the results with hose conventional CMOS logic circuit. The MTJ-based logic circuit are found to be robust compared with conventional CMOS logic circuits at the cost longer delay and higher power dissipation.

The active power is one of the major contributors to the total power consumption in the SRAM cell. It consists mainly of two components -- write power and read power. These power dissipations occur due to charging/discharging of large bit line capacitance. On-chip cache size has become increasingly important for high performance applications, and it now presents more of a limit to microprocessor speed than clock rate. The models and methodologies for the design of SRAM, an integral component of microprocessor cache, have changed with time. Presently, continued scaling is threatened by variability in SRAM performance and function. This work addresses the emerging threat of variability keeping active power consumption and speed of operation in consideration.

Ultra low power -- efficient VLSI circuits design received wide attention due to rapid growth of portable applications. The portable domain places inflexible constraint on the power consumption. Though, device operating in sub threshold region shows huge potential towards satisfying the ULP requirement, it holds lots of difficult design issues. As integration density of interconnects increases at every technology node, increased delay and cross talk effects may becomes a more challenging design problem particularly for sub threshold interconnects. Nanometer sub threshold global interconnect faces sub threshold driver design challenges and problems due to increased interconnect capacitance. This paper examined and compared the effect of cross talk on delay for mixed wall carbon nano tube and Cu interconnects. This work reports new aspect ratio for global interconnect to reduce the effect of cross talk on interconnect performance under sub threshold conditions.