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1. Characterizing Long COVID in Children and Adolescents

Author

Gross, Rachel S, Thaweethai, Tanayott, Kleinman, Lawrence C, Snowden, Jessica N, Rosenzweig, Erika B, Milner, Joshua D, Tantisira, Kelan G, Rhee, Kyung E, Jernigan, Terry L, Kinser, Patricia A, Salisbury, Amy L, Warburton, David, Mohandas, Sindhu, Wood, John C, Newburger, Jane W, Truong, Dongngan T, Flaherman, Valerie J, Metz, Torri D, Karlson, Elizabeth W, Chibnik, Lori B, Pant, Deepti B, Krishnamoorthy, Aparna, Gallagher, Richard, Lamendola-Essel, Michelle F, Hasson, Denise C, Katz, Stuart D, Yin, Shonna, Dreyer, Benard P, Carmilani, Megan, Coombs, K, Fitzgerald, Megan L, Güthe, Nick, Hornig, Mady, Letts, Rebecca J, Peddie, Aimee K, Taylor, Brittany D, Foulkes, Andrea S, Stockwell, Melissa S, Balaraman, Venkataraman, Bogie, Amanda, Bukulmez, Hulya, Dozor, Allen J, Eckrich, Daniel, Elliott, Amy J, Evans, Danielle N, Farkas, Jonathan S, Faustino, E Vincent S, Fischer, Laura, Gaur, Sunanda, Harahsheh, Ashraf S, Hasan, Uzma N, Hsia, Daniel S, Huerta-Montanez, Gredia, Hummel, Kathy D, Kadish, Matt P, Kaelber, David C, Krishnan, Sankaran, Kosut, Jessica S, Larrabee, Jerry, Lim, Peter Paul C, Michelow, Ian C, Oliveira, Carlos R, Raissy, Hengameh, Rosario-Pabon, Zaira, Ross, Judith L, Sato, Alice I, Stevenson, Michelle D, Talavera-Barber, Maria M, Teufel, Ronald J, Weakley, Kathryn E, Zimmerman, Emily, Bind, Marie-Abele C, Chan, James, Guan, Zoe, Morse, Richard E, Reeder, Harrison T, Akshoomoff, Natascha, Aschner, Judy L, Bhattacharjee, Rakesh, Cottrell, Lesley A, Cowan, Kelly, D'Sa, Viren A, Fiks, Alexander G, Gennaro, Maria L, Irby, Katherine, Khare, Manaswitha, Landeo Guttierrez, Jeremy, McCulloh, Russell J, Narang, Shalu, Ness- Cochinwala, Manette, Nolan, Sheila, Palumbo, Paul, Ryu, Julie, Salazar, Juan C, Selvarangan, Rangaraj, Stein, Cheryl R, Werzberger, Alan, Zempsky, William T, Aupperle, Robin, and Baker, Fiona C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Emerging Infectious Diseases, Neurosciences, Coronaviruses, Infectious Diseases, Pediatric, Minority Health, Pain Research, Infection, Good Health and Well Being, RECOVER-Pediatrics Consortium, RECOVER-Pediatrics Group Authors, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

ImportanceMost research to understand postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, has focused on adults, with less known about this complex condition in children. Research is needed to characterize pediatric PASC to enable studies of underlying mechanisms that will guide future treatment.ObjectiveTo identify the most common prolonged symptoms experienced by children (aged 6 to 17 years) after SARS-CoV-2 infection, how these symptoms differ by age (school-age [6-11 years] vs adolescents [12-17 years]), how they cluster into distinct phenotypes, and what symptoms in combination could be used as an empirically derived index to assist researchers to study the likely presence of PASC.Design, setting, and participantsMulticenter longitudinal observational cohort study with participants recruited from more than 60 US health care and community settings between March 2022 and December 2023, including school-age children and adolescents with and without SARS-CoV-2 infection history.ExposureSARS-CoV-2 infection.Main outcomes and measuresPASC and 89 prolonged symptoms across 9 symptom domains.ResultsA total of 898 school-age children (751 with previous SARS-CoV-2 infection [referred to as infected] and 147 without [referred to as uninfected]; mean age, 8.6 years; 49% female; 11% were Black or African American, 34% were Hispanic, Latino, or Spanish, and 60% were White) and 4469 adolescents (3109 infected and 1360 uninfected; mean age, 14.8 years; 48% female; 13% were Black or African American, 21% were Hispanic, Latino, or Spanish, and 73% were White) were included. Median time between first infection and symptom survey was 506 days for school-age children and 556 days for adolescents. In models adjusted for sex and race and ethnicity, 14 symptoms in both school-age children and adolescents were more common in those with SARS-CoV-2 infection history compared with those without infection history, with 4 additional symptoms in school-age children only and 3 in adolescents only. These symptoms affected almost every organ system. Combinations of symptoms most associated with infection history were identified to form a PASC research index for each age group; these indices correlated with poorer overall health and quality of life. The index emphasizes neurocognitive, pain, and gastrointestinal symptoms in school-age children but change or loss in smell or taste, pain, and fatigue/malaise-related symptoms in adolescents. Clustering analyses identified 4 PASC symptom phenotypes in school-age children and 3 in adolescents.Conclusions and relevanceThis study developed research indices for characterizing PASC in children and adolescents. Symptom patterns were similar but distinguishable between the 2 groups, highlighting the importance of characterizing PASC separately for these age ranges.

Published
2024

2. Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design.

Author

Gross, Rachel, Thaweethai, Tanayott, Rosenzweig, Erika, Chan, James, Chibnik, Lori, Cicek, Mine, Elliott, Amy, Flaherman, Valerie, Foulkes, Andrea, Gage Witvliet, Margot, Gallagher, Richard, Gennaro, Maria, Jernigan, Terry, Karlson, Elizabeth, Katz, Stuart, Kinser, Patricia, Kleinman, Lawrence, Lamendola-Essel, Michelle, Milner, Joshua, Mohandas, Sindhu, Mudumbi, Praveen, Newburger, Jane, Rhee, Kay, Salisbury, Amy, Snowden, Jessica, Stein, Cheryl, Stockwell, Melissa, Tantisira, Kelan, Thomason, Moriah, Truong, Dongngan, Warburton, David, Wood, John, Ahmed, Shifa, Akerlundh, Almary, Alshawabkeh, Akram, Anderson, Brett, Aschner, Judy, Atz, Andrew, Aupperle, Robin, Baker, Fiona, Balaraman, Venkataraman, Banerjee, Dithi, Barch, Deanna, Baskin-Sommers, Arielle, Bhuiyan, Sultana, Bind, Marie-Abele, Bogie, Amanda, Bradford, Tamara, Buchbinder, Natalie, Bueler, Elliott, Bükülmez, Hülya, Casey, B, Chang, Linda, Chrisant, Maryanne, Clark, Duncan, Clifton, Rebecca, Clouser, Katharine, Cottrell, Lesley, Cowan, Kelly, DSa, Viren, Dapretto, Mirella, Dasgupta, Soham, Dehority, Walter, Dionne, Audrey, Dummer, Kirsten, Elias, Matthew, Esquenazi-Karonika, Shari, Evans, Danielle, Faustino, E, Fiks, Alexander, Forsha, Daniel, Foxe, John, Friedman, Naomi, Fry, Greta, Gaur, Sunanda, Gee, Dylan, Gray, Kevin, Handler, Stephanie, Harahsheh, Ashraf, Hasbani, Keren, Heath, Andrew, Hebson, Camden, Heitzeg, Mary, Hester, Christina, Hill, Sophia, Hobart-Porter, Laura, Hong, Travis, Horowitz, Carol, Hsia, Daniel, Huentelman, Matthew, Hummel, Kathy, Irby, Katherine, Jacobus, Joanna, Jacoby, Vanessa, Jone, Pei-Ni, Kaelber, David, Kasmarcak, Tyler, Kluko, Matthew, Kosut, Jessica, and Laird, Angela

Subjects
Humans, COVID-19, Adolescent, Child, Child, Preschool, Female, Young Adult, Adult, Male, Infant, SARS-CoV-2, Infant, Newborn, Prospective Studies, Research Design, Cohort Studies, Post-Acute COVID-19 Syndrome
Abstract

IMPORTANCE: The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or Long COVID) in children and young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, and potential treatment targets in children and young adults. OBSERVATIONS: We describe the protocol for the Pediatric Observational Cohort Study of the NIHs REsearching COVID to Enhance Recovery (RECOVER) Initiative. RECOVER-Pediatrics is an observational meta-cohort study of caregiver-child pairs (birth through 17 years) and young adults (18 through 25 years), recruited from more than 100 sites across the US. This report focuses on two of four cohorts that comprise RECOVER-Pediatrics: 1) a de novo RECOVER prospective cohort of children and young adults with and without previous or current infection; and 2) an extant cohort derived from the Adolescent Brain Cognitive Development (ABCD) study (n = 10,000). The de novo cohort incorporates three tiers of data collection: 1) remote baseline assessments (Tier 1, n = 6000); 2) longitudinal follow-up for up to 4 years (Tier 2, n = 6000); and 3) a subset of participants, primarily the most severely affected by PASC, who will undergo deep phenotyping to explore PASC pathophysiology (Tier 3, n = 600). Youth enrolled in the ABCD study participate in Tier 1. The pediatric protocol was developed as a collaborative partnership of investigators, patients, researchers, clinicians, community partners, and federal partners, intentionally promoting inclusivity and diversity. The protocol is adaptive to facilitate responses to emerging science. CONCLUSIONS AND RELEVANCE: RECOVER-Pediatrics seeks to characterize the clinical course, underlying mechanisms, and long-term effects of PASC from birth through 25 years old. RECOVER-Pediatrics is designed to elucidate the epidemiology, four-year clinical course, and sociodemographic correlates of pediatric PASC. The data and biosamples will allow examination of mechanistic hypotheses and biomarkers, thus providing insights into potential therapeutic interventions. CLINICAL TRIALS.GOV IDENTIFIER: Clinical Trial Registration: http://www.clinicaltrials.gov. Unique identifier: NCT05172011.

Published
2024

3. A machine-learning algorithm for diagnosis of multisystem inflammatory syndrome in children and Kawasaki disease in the USA: a retrospective model development and validation study

Author

Lam, Jonathan Y, Shimizu, Chisato, Tremoulet, Adriana H, Bainto, Emelia, Roberts, Samantha C, Sivilay, Nipha, Gardiner, Michael A, Kanegaye, John T, Hogan, Alexander H, Salazar, Juan C, Mohandas, Sindhu, Szmuszkovicz, Jacqueline R, Mahanta, Simran, Dionne, Audrey, Newburger, Jane W, Ansusinha, Emily, DeBiasi, Roberta L, Hao, Shiying, Ling, Xuefeng B, Cohen, Harvey J, Nemati, Shamim, Burns, Jane C, Group, Pediatric Emergency Medicine Kawasaki Disease Research, Abe, Naomi, Austin-Page, Lukas R, Bryl, Amy W, Donofrio-Odmann, J Joelle, Ekpenyong, Atim, Gutglass, David J, Nguyen, Margaret B, Schwartz, Kristy, Ulrich, Stacey, Vayngortin, Tatyana, Zimmerman, Elise, Group, CHARMS Study, Anderson, Marsha, Ang, Jocelyn Y, Ashouri, Negar, Bocchini, Joseph, D'Addese, Laura, Dominguez, Samuel, Gutierrez, Maria Pila, Harahsheh, Ashraf S, Hite, Michelle, Jone, Pei-Ni, Kumar, Madan, Manaloor, John J, Melish, Marian, Morgan, Lerraughn, Natale, JoAnne E, Rometo, Allison, Rosenkranz, Margalit, Rowley, Anne H, Samuy, Nichole, Scalici, Paul, and Sykes, Michelle

Subjects
Health Services and Systems, Health Sciences, Patient Safety, Prevention, Rare Diseases, Clinical Research, Pediatric, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Algorithms, Artificial Intelligence, COVID-19, COVID-19 Testing, Child, Humans, Machine Learning, Mucocutaneous Lymph Node Syndrome, Pandemics, Retrospective Studies, SARS-CoV-2, Systemic Inflammatory Response Syndrome, United States, Pediatric Emergency Medicine Kawasaki Disease Research Group, CHARMS Study Group, Health services and systems
Abstract

BackgroundMultisystem inflammatory syndrome in children (MIS-C) is a novel disease that was identified during the COVID-19 pandemic and is characterised by systemic inflammation following SARS-CoV-2 infection. Early detection of MIS-C is a challenge given its clinical similarities to Kawasaki disease and other acute febrile childhood illnesses. We aimed to develop and validate an artificial intelligence algorithm that can distinguish among MIS-C, Kawasaki disease, and other similar febrile illnesses and aid in the diagnosis of patients in the emergency department and acute care setting.MethodsIn this retrospective model development and validation study, we developed a deep-learning algorithm called KIDMATCH (Kawasaki Disease vs Multisystem Inflammatory Syndrome in Children) using patient age, the five classic clinical Kawasaki disease signs, and 17 laboratory measurements. All features were prospectively collected at the time of initial evaluation from patients diagnosed with Kawasaki disease or other febrile illness between Jan 1, 2009, and Dec 31, 2019, at Rady Children's Hospital in San Diego (CA, USA). For patients with MIS-C, the same data were collected from patients between May 7, 2020, and July 20, 2021, at Rady Children's Hospital, Connecticut Children's Medical Center in Hartford (CT, USA), and Children's Hospital Los Angeles (CA, USA). We trained a two-stage model consisting of feedforward neural networks to distinguish between patients with MIS-C and those without and then those with Kawasaki disease and other febrile illnesses. After internally validating the algorithm using stratified tenfold cross-validation, we incorporated a conformal prediction framework to tag patients with erroneous data or distribution shifts. We finally externally validated KIDMATCH on patients with MIS-C enrolled between April 22, 2020, and July 21, 2021, from Boston Children's Hospital (MA, USA), Children's National Hospital (Washington, DC, USA), and the CHARMS Study Group consortium of 14 US hospitals.Findings1517 patients diagnosed at Rady Children's Hospital between Jan 1, 2009, and June 7, 2021, with MIS-C (n=69), Kawasaki disease (n=775), or other febrile illnesses (n=673) were identified for internal validation, with an additional 16 patients with MIS-C included from Connecticut Children's Medical Center and 50 from Children's Hospital Los Angeles between May 7, 2020, and July 20, 2021. KIDMATCH achieved a median area under the receiver operating characteristic curve during internal validation of 98·8% (IQR 98·0-99·3) in the first stage and 96·0% (95·6-97·2) in the second stage. We externally validated KIDMATCH on 175 patients with MIS-C from Boston Children's Hospital (n=50), Children's National Hospital (n=42), and the CHARMS Study Group consortium of 14 US hospitals (n=83). External validation of KIDMATCH on patients with MIS-C correctly classified 76 of 81 patients (94% accuracy, two rejected by conformal prediction) from 14 hospitals in the CHARMS Study Group consortium, 47 of 49 patients (96% accuracy, one rejected by conformal prediction) from Boston Children's Hospital, and 36 of 40 patients (90% accuracy, two rejected by conformal prediction) from Children's National Hospital.InterpretationKIDMATCH has the potential to aid front-line clinicians to distinguish between MIS-C, Kawasaki disease, and other similar febrile illnesses to allow prompt treatment and prevent severe complications.FundingUS Eunice Kennedy Shriver National Institute of Child Health and Human Development, US National Heart, Lung, and Blood Institute, US Patient-Centered Outcomes Research Institute, US National Library of Medicine, the McCance Foundation, and the Gordon and Marilyn Macklin Foundation.

Published
2022

4. The NHLBI Study on Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC): Design and Objectives

Author

Truong, Dongngan T, Trachtenberg, Felicia L, Pearson, Gail D, Dionne, Audrey, Elias, Matthew D, Friedman, Kevin, Hayes, Kerri H, Mahony, Lynn, McCrindle, Brian W, Oster, Matthew E, Pemberton, Victoria, Powell, Andrew J, Russell, Mark W, Shekerdemian, Lara S, Son, Mary Beth, Taylor, Michael, Newburger, Jane W, Investigators, for the MUSIC Study, Giglia, Therese M, McHugh, Kimberly E, Atz, Andrew M, Pletzer, Scott A, Lang, Sean M, Payne, R Mark, Patel, Jyoti K, Pignatelli, Ricardo H, Sexson, Kristen, Lam, Christopher, Dragulescu, Andreea, Young, Rae SM, Gamulka, Beth, Krishnan, Anita, Anderson, Brett R, Farooqi, Kanwal M, Shakti, Divya, Parnell, Aimee S, Osakwe, Onyekachukwu J, Sykes, Michelle C, Morgan, Lerraughn, Owada, Carl Y, Forsha, Daniel, Carr, Michael R, Watanabe, Kae, Portman, Michael A, Dummer, Kristen B, Burns, Jane C, Tremoulet, Adriana H, Sharma, Kavita, Jone, Pei-Ni, Heizer, Michelle Hite Heather, Hasbani, Keren, Srivastava, Shubhika, Mitchell, Elizabeth C, Hebson, Camden L, Szmuszkovicz, Jacqueline R, Wong, Pierre C, Cheng, Andrew L, Votava-Smith, Jodie K, Wang, Shuo, Mohandas, Sindhu, Singh, Gautam K, Aggarwal, Sanjeev, Sanil, Yamuna, Bradford, Tamara T, Muniz, Juan Carlos G, Li, Jennifer S, Campbell, Michael Jay, Handler, Stephanie S, Shea, J Ryan, Hoffman, Timothy M, Franklin, Wayne J, Sabati, Arash A, Nowlen, Todd T, and Chrisant, Maryanne

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Heart Disease, Biomedical Imaging, Clinical Trials and Supportive Activities, Cardiovascular, Clinical Research, Prevention, Pediatric, Patient Safety, Adult, COVID-19, Child, Heart, Humans, Magnetic Resonance Imaging, National Heart, Lung, and Blood Institute (U.S.), SARS-CoV-2, Stroke Volume, Systemic Inflammatory Response Syndrome, United States, Ventricular Function, Left, Young Adult, MUSIC Study Investigators, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundThe Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC) study aims to characterize the frequency and time course of acute and long-term cardiac and non-cardiac sequelae in multisystem inflammatory syndrome in children associated with COVID-19 (MIS-C), which are currently poorly understood.MethodsThis multicenter observational cohort study will enroll at least 600 patients

Published
2022

5. Kawasaki Disease in the Time of COVID-19 and MIS-C: The International Kawasaki Disease Registry

Author

Alsalehi, Mahmoud, Ballweg, Jean A., Barnes, Benjamin, Braunlin, Elizabeth, Buffone, Ashley, Bustamante-Ogando, Juan Carlos, Chang, Arthur J., Corral, Nicolas, Dancey, Paul, El-Ganzoury, Mona, El-Samman, Nora, Elias, Matthew, Fernandez-Cooke, Elisa, Friedman, Kevin, Garrido-Garcia, Luis Martin, Garrido, Luis Martin, Goldenberg, Guillermo Larios, Grcic, Michelle M., Harris, Kevin C., Hicar, Mark D., Hindt, Bridgette, Jone, Pei-Ni, Kajimoto, Hidemi, Kaneta, Kelli, Khare, Manaswitha, Knutson, Stacie, Kutty, Shelby, Lanari, Marcello, Maksymiuk, Victoria, McHugh, Kimberly E., Merves, Shae, Misra, Nilanjana, Mohandas, Sindhu, Mondal, Tapas, Norozi, Kambiz, Nowlen, Todd, Pagano, Joseph J., Prasad, Deepa, Raghuveer, Geetha, Ravi, Prasad, Sundaram, Balasubramanian, Sehgal, Anupam, Shah, Ashish, Vázquez, Belén Toral, Tremoulet, Adriana H., Venkataraman, Aishwarya, Watelle, Laurence, Yamazaki-Naksahimada, Marco Antonio, Yetman, Anji T., Harahsheh, Ashraf S., Shah, Samay, Dallaire, Frederic, Manlhiot, Cedric, Khoury, Michael, Lee, Simon, Fabi, Marianna, Mauriello, Daniel, Tierney, Elif Seda Selamet, Sabati, Arash A., Dionne, Audrey, Dahdah, Nagib, Choueiter, Nadine, Thacker, Deepika, Giglia, Therese M., Truong, Dongngan T., Jain, Supriya, Portman, Michael, Orr, William B., Harris, Tyler H., Szmuszkovicz, Jacqueline R., Farid, Pedrom, and McCrindle, Brian W.

Published
2024
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6. A machine-learning algorithm for diagnosis of multisystem inflammatory syndrome in children and Kawasaki disease in the USA: a retrospective model development and validation study

Author

Abe, Naomi, Austin-Page, Lukas R., Bryl, Amy W., Donofrio-Odmann, J Joelle, Ekpenyong, Atim, Gutglass, David J., Nguyen, Margaret B., Schwartz, Kristy, Ulrich, Stacey, Vayngortin, Tatyana, Zimmerman, Elise, Anderson, Marsha, Ang, Jocelyn Y., Ashouri, Negar, Bocchini, Joseph, D'Addese, Laura, Dominguez, Samuel, Gutierrez, Maria Pila, Harahsheh, Ashraf S., Hite, Michelle, Jone, Pei-Ni, Kumar, Madan, Manaloor, John J., Melish, Marian, Morgan, Lerraughn, Natale, JoAnne E., Rometo, Allison, Rosenkranz, Margalit, Rowley, Anne H., Samuy, Nichole, Scalici, Paul, Sykes, Michelle, Lam, Jonathan Y, Shimizu, Chisato, Tremoulet, Adriana H, Bainto, Emelia, Roberts, Samantha C, Sivilay, Nipha, Gardiner, Michael A, Kanegaye, John T, Hogan, Alexander H, Salazar, Juan C, Mohandas, Sindhu, Szmuszkovicz, Jacqueline R, Mahanta, Simran, Dionne, Audrey, Newburger, Jane W, Ansusinha, Emily, DeBiasi, Roberta L, Hao, Shiying, Ling, Xuefeng B, Cohen, Harvey J, Nemati, Shamim, and Burns, Jane C

Published
2022
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8. Characterizing Long COVID in Children and Adolescents.

Author

Gross, Rachel S., Thaweethai, Tanayott, Kleinman, Lawrence C., Snowden, Jessica N., Rosenzweig, Erika B., Milner, Joshua D., Tantisira, Kelan G., Rhee, Kyung E., Jernigan, Terry L., Kinser, Patricia A., Salisbury, Amy L., Warburton, David, Mohandas, Sindhu, Wood, John C., Newburger, Jane W., Truong, Dongngan T., Flaherman, Valerie J., Metz, Torri D., Karlson, Elizabeth W., and Chibnik, Lori B.

Subjects
POST-acute COVID-19 syndrome, RACE, AGE groups, QUALITY of life, AFRICAN Americans
Abstract

Key Points: Question: What prolonged symptoms experienced by youth are most associated with SARS-CoV-2 infection? Findings: Among 5367 participants in the RECOVER-Pediatrics cohort study, 14 symptoms in both school-age children (6-11 years) and adolescents (12-17 years) were more common in those with vs without SARS-CoV-2 infection history, with 4 additional symptoms in school-age children only and 3 in adolescents only. Empirically derived indices for PASC research and associated clustering patterns were developed. Meaning: This study developed research indices for characterizing pediatric PASC. Symptom patterns were similar but distinguishable between school-age children and adolescents, highlighting the importance of characterizing PASC separately in different age groups. Importance: Most research to understand postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, has focused on adults, with less known about this complex condition in children. Research is needed to characterize pediatric PASC to enable studies of underlying mechanisms that will guide future treatment. Objective: To identify the most common prolonged symptoms experienced by children (aged 6 to 17 years) after SARS-CoV-2 infection, how these symptoms differ by age (school-age [6-11 years] vs adolescents [12-17 years]), how they cluster into distinct phenotypes, and what symptoms in combination could be used as an empirically derived index to assist researchers to study the likely presence of PASC. Design, Setting, and Participants: Multicenter longitudinal observational cohort study with participants recruited from more than 60 US health care and community settings between March 2022 and December 2023, including school-age children and adolescents with and without SARS-CoV-2 infection history. Exposure: SARS-CoV-2 infection. Main Outcomes and Measures: PASC and 89 prolonged symptoms across 9 symptom domains. Results: A total of 898 school-age children (751 with previous SARS-CoV-2 infection [referred to as infected] and 147 without [referred to as uninfected]; mean age, 8.6 years; 49% female; 11% were Black or African American, 34% were Hispanic, Latino, or Spanish, and 60% were White) and 4469 adolescents (3109 infected and 1360 uninfected; mean age, 14.8 years; 48% female; 13% were Black or African American, 21% were Hispanic, Latino, or Spanish, and 73% were White) were included. Median time between first infection and symptom survey was 506 days for school-age children and 556 days for adolescents. In models adjusted for sex and race and ethnicity, 14 symptoms in both school-age children and adolescents were more common in those with SARS-CoV-2 infection history compared with those without infection history, with 4 additional symptoms in school-age children only and 3 in adolescents only. These symptoms affected almost every organ system. Combinations of symptoms most associated with infection history were identified to form a PASC research index for each age group; these indices correlated with poorer overall health and quality of life. The index emphasizes neurocognitive, pain, and gastrointestinal symptoms in school-age children but change or loss in smell or taste, pain, and fatigue/malaise–related symptoms in adolescents. Clustering analyses identified 4 PASC symptom phenotypes in school-age children and 3 in adolescents. Conclusions and Relevance: This study developed research indices for characterizing PASC in children and adolescents. Symptom patterns were similar but distinguishable between the 2 groups, highlighting the importance of characterizing PASC separately for these age ranges. This observational cohort study examines the symptoms experienced by children after SARS-CoV-2 infection and how these symptoms differ by age (6-11 years vs 12-17 years). [ABSTRACT FROM AUTHOR]

Published
2024
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9. The NHLBI Study on Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC): Design and Objectives

Author

Dionne, Audrey, Elias, Matthew D., Giglia, Therese M., McHugh, Kimberly E., Atz, Andrew M., Pletzer, Scott A., Truong, Dongngan T., Russell, Mark W., Lang, Sean M., Payne, R. Mark, Patel, Jyoti K., Oster, Matthew E., Shekerdemian, Lara S., Pignatelli, Ricardo H., Sexson, Kristen, McCrindle, Brian W., Lam, Christopher, Dragulescu, Andreea, Young, Rae SM, Gamulka, Beth, Krishnan, Anita, Anderson, Brett R., Farooqi, Kanwal M., Shakti, Divya, Parnell, Aimee S., Osakwe, Onyekachukwu J, Sykes, Michelle C., Morgan, Lerraughn, Owada, Carl Y., Forsha, Daniel, Carr, Michael R., Watanabe, Kae, Portman, Michael A., Dummer, Kristen B., Burns, Jane C., Tremoulet, Adriana H., Sharma, Kavita, Jone, Pei-Ni, Heizer, Michelle Hite Heather, Hasbani, Keren, Srivastava, Shubhika, Mitchell, Elizabeth C, Hebson, Camden L., Szmuszkovicz, Jacqueline R., Wong, Pierre C., Cheng, Andrew L., Votava-Smith, Jodie K., Wang, Shuo, Mohandas, Sindhu, Singh, Gautam K., Aggarwal, Sanjeev, Sanil, Yamuna, Bradford, Tamara T., Muniz, Juan Carlos G., Li, Jennifer S., Campbell, Michael Jay, Handler, Stephanie S., Shea, J Ryan, Hoffman, Timothy M., Franklin, Wayne J., Sabati, Arash A., Nowlen, Todd T., Chrisant, Maryanne, Trachtenberg, Felicia L., Pearson, Gail D., Friedman, Kevin, Hayes, Kerri H., Mahony, Lynn, Pemberton, Victoria, Powell, Andrew J., Son, Mary Beth, Taylor, Michael, and Newburger, Jane W.

Published
2022
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11. Long COVID incidence in adults and children between 2020 and 2023: a real-world data study from the RECOVER Initiative

Author

Mandel, Hannah, primary, Yoo, Yun, additional, Allen, Andrea, additional, Abedian, Sajjad, additional, Verzani, Zoe, additional, Karlson, Elizabeth, additional, Kleinman, Lawrence, additional, Mudumbi, Praveen, additional, Oliveira, Carlos, additional, Muszynski, Jennifer, additional, Gross, Rachel, additional, Carton, Thomas, additional, Kim, C., additional, Taylor, Emily, additional, Park, Heekyong, additional, Divers, Jasmin, additional, Kelly, J., additional, Arnold, Jonathan, additional, Geary, Carol, additional, Zang, Chengxi, additional, Tantisira, Kelan, additional, Rhee, Kyung, additional, Koropsak, Michael, additional, Mohandas, Sindhu, additional, Vasey, Andrew, additional, Weiner, Mark, additional, Mosa, Abu, additional, Haendel, Melissa, additional, Chute, Christopher, additional, Murphy, Shawn, additional, O'Brien, Lisa, additional, Szmuszkovicz, Jacqueline, additional, Güthe, Nicholas, additional, Santana, Jorge, additional, De, Aliva, additional, Bogie, Amanda, additional, Halabi, Katia, additional, Mohanraj, Lathika, additional, Kinser, Patricia, additional, Packard, Samuel, additional, Tuttle, Katherine, additional, Thorpe, Lorna, additional, and Moffitt, Richard, additional

Published
2024
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12. Postacute Sequelae of SARS-CoV-2 in Children

Author

Rao, Suchitra, primary, Gross, Rachel S., additional, Mohandas, Sindhu, additional, Stein, Cheryl R., additional, Case, Abigail, additional, Dreyer, Benard, additional, Pajor, Nathan M., additional, Bunnell, H. Timothy, additional, Warburton, David, additional, Berg, Elizabeth, additional, Overdevest, Jonathan B., additional, Gorelik, Mark, additional, Milner, Joshua, additional, Saxena, Sejal, additional, Jhaveri, Ravi, additional, Wood, John C., additional, Rhee, Kyung E., additional, Letts, Rebecca, additional, Maughan, Christine, additional, Guthe, Nick, additional, Castro-Baucom, Leah, additional, and Stockwell, Melissa S., additional

Published
2024
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15. Safety and Immunogenicity of Live Viral Vaccines in a Multicenter Cohort of Pediatric Transplant Recipients

Author

Feldman, Amy G., primary, Beaty, Brenda L., additional, Ferrolino, Jose A., additional, Maron, Gabriela, additional, Weidner, Hillary K., additional, Ali, Saira A., additional, Bitterfeld, Leandra, additional, Boulware, Mary Alice, additional, Campbell, Kathleen M., additional, Carr, Emily, additional, Chapman, Shelley, additional, Chang, Yeh-Chung, additional, Cunningham, Ryan, additional, Dallas, Ronald H., additional, Dantuluri, Keerti L., additional, Domenick, Bryanna N., additional, Ebel, Noelle H., additional, Elisofon, Scott, additional, Fawaz, Rima, additional, Foca, Marc, additional, Gans, Hayley A., additional, Gopalareddy, Vani V., additional, Gu, Cindy, additional, Gupta, Nitika A., additional, Harmann, Katherine, additional, Hollenbeck, Jessica, additional, Huppler, Anna R., additional, Jaramillo, Catalina, additional, Kasi, Nagraj, additional, Kerkar, Nanda, additional, Lerret, Stacee, additional, Lobritto, Steven J., additional, Lopez, Maclovio J., additional, Marini, Elizabeth, additional, Mavis, Alisha, additional, Mehra, Sonia, additional, Moats, Lynnette, additional, Mohandas, Sindhu, additional, Munoz, Flor M., additional, Mysore, Krupa R., additional, Onsan, Ceren, additional, Ovchinsky, Nadia, additional, Perkins, Kerrigan, additional, Postma, Stacy, additional, Pratscher, Lauren, additional, Rand, Elizabeth B., additional, Rowe, Regina K., additional, Schultz, Danielle, additional, Sear, Katherine, additional, Sell, Megan L., additional, Sharma, Tanvi, additional, Stoll, Janis, additional, Vang, Mychoua, additional, Villarin, Dominique, additional, Weaver, Carly, additional, Wood, Phoebe, additional, Woodford-Berry, Olivia, additional, Yanni, George, additional, and Danziger-Isakov, Lara A., additional

Published
2023
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16. Cardiac Biomarkers Aid in Differentiation of Kawasaki Disease from Multisystem Inflammatory Syndrome in Children Associated with COVID-19

Author

Walton, Mollie, primary, Raghuveer, Geetha, additional, Harahsheh, Ashraf, additional, Portman, Michael A., additional, Lee, Simon, additional, Khoury, Michael, additional, Dahdah, Nagib, additional, Fabi, Marianna, additional, Dionne, Audrey, additional, Harris, Tyler H., additional, Choueiter, Nadine, additional, Garrido-Garcia, Luis Martin, additional, Jain, Supriya, additional, Dallaire, Frédéric, additional, Misra, Nilanjana, additional, Hicar, Mark D., additional, Giglia, Therese M., additional, Truong, Dongngan T., additional, Tierney, Elif Seda Selamet, additional, Thacker, Deepika, additional, Nowlen, Todd T., additional, Szmuszkovicz, Jacqueline R., additional, Norozi, Kambiz, additional, Orr, William B., additional, Farid, Pedrom, additional, Manlhiot, Cedric, additional, McCrindle, Brian W., additional, Alsalehi, Mahmoud, additional, Ballweg, Jean A., additional, Barnes, Benjamin T., additional, Braunlin, Elizabeth, additional, Buffone, Ashley, additional, Bustamante-Ogando, Juan Carlos, additional, Chang, Arthur J., additional, Corral, Nicolas, additional, Cowles, Heather, additional, Dancey, Paul, additional, de Ferranti, Sarah D, additional, Ganzoury, Mona El, additional, Elias, Matthew, additional, Elsamman, Nora, additional, Cooke, Elisa Fernández, additional, Goldenberg, Guillermo Larios, additional, Grcic, Michelle M., additional, Harris, Kevin C., additional, Jone, Pei-Ni, additional, Kajimoto, Hidemi, additional, Khare, Manaswitha, additional, Kutty, Shelby, additional, Lanari, Marcello, additional, Mauriello, Daniel, additional, McHugh, Kimberly E., additional, Merves, Shae A., additional, Mohandas, Sindhu, additional, Mondal, Tapas, additional, Pagano, Joseph J., additional, Prasad, Deepa, additional, and Ravi, Prasad, additional

Published
2023
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18. Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design

Author

Horwitz, Leora I., primary, Thaweethai, Tanayott, additional, Brosnahan, Shari B., additional, Cicek, Mine S., additional, Fitzgerald, Megan L., additional, Goldman, Jason D., additional, Hess, Rachel, additional, Hodder, S. L., additional, Jacoby, Vanessa L., additional, Jordan, Michael R., additional, Krishnan, Jerry A., additional, Laiyemo, Adeyinka O., additional, Metz, Torri D., additional, Nichols, Lauren, additional, Patzer, Rachel E., additional, Sekar, Anisha, additional, Singer, Nora G., additional, Stiles, Lauren E., additional, Taylor, Barbara S., additional, Ahmed, Shifa, additional, Algren, Heather A., additional, Anglin, Khamal, additional, Aponte-Soto, Lisa, additional, Ashktorab, Hassan, additional, Bassett, Ingrid V., additional, Bedi, Brahmchetna, additional, Bhadelia, Nahid, additional, Bime, Christian, additional, Bind, Marie-Abele C., additional, Black, Lora J., additional, Blomkalns, Andra L., additional, Brim, Hassan, additional, Castro, Mario, additional, Chan, James, additional, Charney, Alexander W., additional, Chen, Benjamin K., additional, Chen, Li Qing, additional, Chen, Peter, additional, Chestek, David, additional, Chibnik, Lori B., additional, Chow, Dominic C., additional, Chu, Helen Y., additional, Clifton, Rebecca G., additional, Collins, Shelby, additional, Costantine, Maged M., additional, Cribbs, Sushma K., additional, Deeks, Steven G., additional, Dickinson, John D., additional, Donohue, Sarah E., additional, Durstenfeld, Matthew S., additional, Emery, Ivette F., additional, Erlandson, Kristine M., additional, Facelli, Julio C., additional, Farah-Abraham, Rachael, additional, Finn, Aloke V., additional, Fischer, Melinda S., additional, Flaherman, Valerie J., additional, Fleurimont, Judes, additional, Fonseca, Vivian, additional, Gallagher, Emily J., additional, Gander, Jennifer C., additional, Gennaro, Maria Laura, additional, Gibson, Kelly S., additional, Go, Minjoung, additional, Goodman, Steven N., additional, Granger, Joey P., additional, Greenway, Frank L., additional, Hafner, John W., additional, Han, Jenny E., additional, Harkins, Michelle S., additional, Hauser, Kristine S. P., additional, Heath, James R., additional, Hernandez, Carla R., additional, Ho, On, additional, Hoffman, Matthew K., additional, Hoover, Susan E., additional, Horowitz, Carol R., additional, Hsu, Harvey, additional, Hsue, Priscilla Y., additional, Hughes, Brenna L., additional, Jagannathan, Prasanna, additional, James, Judith A., additional, John, Janice, additional, Jolley, Sarah, additional, Judd, S. E., additional, Juskowich, Joy J., additional, Kanjilal, Diane G., additional, Karlson, Elizabeth W., additional, Katz, Stuart D., additional, Kelly, J. Daniel, additional, Kelly, Sara W., additional, Kim, Arthur Y., additional, Kirwan, John P., additional, Knox, Kenneth S., additional, Kumar, Andre, additional, Lamendola-Essel, Michelle F., additional, Lanca, Margaret, additional, Lee-lannotti, Joyce K., additional, Lefebvre, R. Craig, additional, Levy, Bruce D., additional, Lin, Janet Y., additional, Logarbo, Brian P., additional, Logue, Jennifer K., additional, Longo, Michele T., additional, Luciano, Carlos A., additional, Lutrick, Karen, additional, Malakooti, Shahdi K., additional, Mallett, Gail, additional, Maranga, Gabrielle, additional, Marathe, Jai G., additional, Marconi, Vincent C., additional, Marshall, Gailen D., additional, Martin, Christopher F., additional, Martin, Jeffrey N., additional, May, Heidi T., additional, McComsey, Grace A., additional, McDonald, Dylan, additional, Mendez-Figueroa, Hector, additional, Miele, Lucio, additional, Mittleman, Murray A., additional, Mohandas, Sindhu, additional, Mouchati, Christian, additional, Mullington, Janet M., additional, Nadkarni, Girish N., additional, Nahin, Erica R., additional, Neuman, Robert B., additional, Newman, Lisa T., additional, Nguyen, Amber, additional, Nikolich, Janko Z., additional, Ofotokun, Igho, additional, Ogbogu, Princess U., additional, Palatnik, Anna, additional, Palomares, Kristy T. S., additional, Parimon, Tanyalak, additional, Parry, Samuel, additional, Parthasarathy, Sairam, additional, Patterson, Thomas F., additional, Pearman, Ann, additional, Peluso, Michael J., additional, Pemu, Priscilla, additional, Pettker, Christian M., additional, Plunkett, Beth A., additional, Pogreba-Brown, Kristen, additional, Poppas, Athena, additional, Porterfield, J. Zachary, additional, Quigley, John G., additional, Quinn, Davin K., additional, Raissy, Hengameh, additional, Rebello, Candida J., additional, Reddy, Uma M., additional, Reece, Rebecca, additional, Reeder, Harrison T., additional, Rischard, Franz P., additional, Rosas, Johana M., additional, Rosen, Clifford J., additional, Rouphael, Nadine G., additional, Rouse, Dwight J., additional, Ruff, Adam M., additional, Saint Jean, Christina, additional, Sandoval, Grecio J., additional, Santana, Jorge L., additional, Schlater, Shannon M., additional, Sciurba, Frank C., additional, Selvaggi, Caitlin, additional, Seshadri, Sudha, additional, Sesso, Howard D., additional, Shah, Dimpy P., additional, Shemesh, Eyal, additional, Sherif, Zaki A., additional, Shinnick, Daniel J., additional, Simhan, Hyagriv N., additional, Singh, Upinder, additional, Sowles, Amber, additional, Subbian, Vignesh, additional, Sun, Jun, additional, Suthar, Mehul S., additional, Teunis, Larissa J., additional, Thorp, John M., additional, Ticotsky, Amberly, additional, Tita, Alan T. N., additional, Tragus, Robin, additional, Tuttle, Katherine R., additional, Urdaneta, Alfredo E., additional, Utz, P. J., additional, VanWagoner, Timothy M., additional, Vasey, Andrew, additional, Vernon, Suzanne D., additional, Vidal, Crystal, additional, Walker, Tiffany, additional, Ward, Honorine D., additional, Warren, David E., additional, Weeks, Ryan M., additional, Weiner, Steven J., additional, Weyer, Jordan C., additional, Wheeler, Jennifer L., additional, Whiteheart, Sidney W., additional, Wiley, Zanthia, additional, Williams, Natasha J., additional, Wisnivesky, Juan P., additional, Wood, John C., additional, Yee, Lynn M., additional, Young, Natalie M., additional, Zisis, Sokratis N., additional, and Foulkes, Andrea S., additional

Published
2023
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19. Kawasaki Disease in the Time of COVID-19 and MIS-C: The International Kawasaki Disease Registry

Author

Harahsheh, Ashraf S., primary, Shah, Samay, additional, Dallaire, Frederic, additional, Manlhiot, Cedric, additional, Khoury, Michael, additional, Lee, Simon, additional, Fabi, Marianna, additional, Mauriello, Daniel, additional, Tierney, Elif Seda Selamet, additional, Sabati, Arash A., additional, Dionne, Audrey, additional, Dahdah, Nagib, additional, Choueiter, Nadine, additional, Thacker, Deepika, additional, Giglia, Therese M., additional, Truong, Dongngan T., additional, Jain, Supriya, additional, Portman, Michael, additional, Orr, William B., additional, Harris, Tyler H., additional, Szmuszkovicz, Jacqueline R., additional, Farid, Pedrom, additional, McCrindle, Brian W., additional, Alsalehi, Mahmoud, additional, Ballweg, Jean A., additional, Barnes, Benjamin, additional, Braunlin, Elizabeth, additional, Buffone, Ashley, additional, Bustamante-Ogando, Juan Carlos, additional, Chang, Arthur J., additional, Corral, Nicolas, additional, Dancey, Paul, additional, El-Ganzoury, Mona, additional, El-Samman, Nora, additional, Elias, Matthew, additional, Fernandez-Cooke, Elisa, additional, Friedman, Kevin, additional, Garrido-Garcia, Luis Martin, additional, Garrido, Luis Martin, additional, Goldenberg, Guillermo Larios, additional, Grcic, Michelle M., additional, Harris, Kevin C., additional, Hicar, Mark D., additional, Hindt, Bridgette, additional, Jone, Pei-Ni, additional, Kajimoto, Hidemi, additional, Kaneta, Kelli, additional, Khare, Manaswitha, additional, Knutson, Stacie, additional, Kutty, Shelby, additional, Lanari, Marcello, additional, Maksymiuk, Victoria, additional, McHugh, Kimberly E., additional, Merves, Shae, additional, Misra, Nilanjana, additional, Mohandas, Sindhu, additional, Mondal, Tapas, additional, Norozi, Kambiz, additional, Nowlen, Todd, additional, Pagano, Joseph J., additional, Prasad, Deepa, additional, Raghuveer, Geetha, additional, Ravi, Prasad, additional, Sundaram, Balasubramanian, additional, Sehgal, Anupam, additional, Shah, Ashish, additional, Vázquez, Belén Toral, additional, Tremoulet, Adriana H., additional, Venkataraman, Aishwarya, additional, Watelle, Laurence, additional, Yamazaki-Naksahimada, Marco Antonio, additional, and Yetman, Anji T., additional

Published
2023
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20. Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOVER initiative

Author

Bonilla, Hector, primary, Peluso, Michael J., additional, Rodgers, Kathleen, additional, Aberg, Judith A., additional, Patterson, Thomas F., additional, Tamburro, Robert, additional, Baizer, Lawrence, additional, Goldman, Jason D., additional, Rouphael, Nadine, additional, Deitchman, Amelia, additional, Fine, Jeffrey, additional, Fontelo, Paul, additional, Kim, Arthur Y., additional, Shaw, Gwendolyn, additional, Stratford, Jeran, additional, Ceger, Patricia, additional, Costantine, Maged M., additional, Fisher, Liza, additional, O’Brien, Lisa, additional, Maughan, Christine, additional, Quigley, John G., additional, Gabbay, Vilma, additional, Mohandas, Sindhu, additional, Williams, David, additional, and McComsey, Grace A., additional

Published
2023
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24. Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC).

Author

Mohandas, Sindhu, Jagannathan, Prasanna, Henrich, Timothy J., Sherif, Zaki A., Bime, Christian, Quinlan, Erin, Portman, Michael A., Gennaro, Marila, and Rehman, Jalees

Subjects
*POST-acute COVID-19 syndrome, *SARS-CoV-2, *COVID-19
Abstract

With a global tally of more than 500 million cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections to date, there are growing concerns about the post-acute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. Recent studies suggest that exaggerated immune responses are key determinants of the severity and outcomes of the initial SARS-CoV-2 infection as well as subsequent PASC. The complexity of the innate and adaptive immune responses in the acute and post-acute period requires in-depth mechanistic analyses to identify specific molecular signals as well as specific immune cell populations which promote PASC pathogenesis. In this review, we examine the current literature on mechanisms of immune dysregulation in severe COVID-19 and the limited emerging data on the immunopathology of PASC. While the acute and post-acute phases may share some parallel mechanisms of immunopathology, it is likely that PASC immunopathology is quite distinct and heterogeneous, thus requiring large-scale longitudinal analyses in patients with and without PASC after an acute SARS-CoV-2 infection. By outlining the knowledge gaps in the immunopathology of PASC, we hope to provide avenues for novel research directions that will ultimately lead to precision therapies which restore healthy immune function in PASC patients. [ABSTRACT FROM AUTHOR]

Published
2023
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26. The NHLBI Study on Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC): Design and Objectives

Author

Truong, Dongngan T., primary, Trachtenberg, Felicia L., additional, Pearson, Gail D., additional, Dionne, Audrey, additional, Elias, Matthew D., additional, Friedman, Kevin, additional, Hayes, Kerri H., additional, Mahony, Lynn, additional, McCrindle, Brian W., additional, Oster, Matthew E., additional, Pemberton, Victoria, additional, Powell, Andrew J., additional, Russell, Mark W., additional, Shekerdemian, Lara S., additional, Son, Mary Beth, additional, Taylor, Michael, additional, Newburger, Jane W., additional, Elias, Matthew D., additional, Giglia, Therese M., additional, McHugh, Kimberly E., additional, Atz, Andrew M., additional, Pletzer, Scott A., additional, Truong, Dongngan T., additional, Lang, Sean M., additional, Payne, R. Mark, additional, Patel, Jyoti K., additional, Oster, Matthew E., additional, Pignatelli, Ricardo H., additional, Sexson, Kristen, additional, Lam, Christopher, additional, Dragulescu, Andreea, additional, Young, Rae SM, additional, Gamulka, Beth, additional, Krishnan, Anita, additional, Anderson, Brett R., additional, Farooqi, Kanwal M., additional, Shakti, Divya, additional, Parnell, Aimee S., additional, Osakwe, Onyekachukwu J, additional, Sykes, Michelle C., additional, Morgan, Lerraughn, additional, Owada, Carl Y., additional, Forsha, Daniel, additional, Carr, Michael R., additional, Watanabe, Kae, additional, Portman, Michael A., additional, Dummer, Kristen B., additional, Burns, Jane C., additional, Tremoulet, Adriana H., additional, Sharma, Kavita, additional, Jone, Pei-Ni, additional, Heizer, Michelle Hite Heather, additional, Hasbani, Keren, additional, Srivastava, Shubhika, additional, Mitchell, Elizabeth C, additional, Hebson, Camden L., additional, Szmuszkovicz, Jacqueline R., additional, Wong, Pierre C., additional, Cheng, Andrew L., additional, Votava-Smith, Jodie K., additional, Wang, Shuo, additional, Mohandas, Sindhu, additional, Singh, Gautam K., additional, Aggarwal, Sanjeev, additional, Sanil, Yamuna, additional, Bradford, Tamara T., additional, Muniz, Juan Carlos G., additional, Li, Jennifer S., additional, Campbell, Michael Jay, additional, Handler, Stephanie S., additional, Shea, J Ryan, additional, Hoffman, Timothy M., additional, Franklin, Wayne J., additional, Sabati, Arash A., additional, Nowlen, Todd T., additional, and Chrisant, Maryanne, additional

Published
2022
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27. Impact of COVID-19 Pandemic on Pediatric Infectious Disease Telehealth Practices in North America.

Author

Kalyoussef, Sabah, Hakim, Amin, Kumar, Ambuj, Fanella, Sergio, Mohandas, Sindhu, Gaviria-Agudelo, Claudia, and Group, PIDS Telehealth Work

Subjects
COMMUNICABLE disease treatment, HEALTH services accessibility, HUMAN comfort, MULTIVARIATE analysis, PEDIATRICS, PHYSICIANS' attitudes, SURVEYS, DESCRIPTIVE statistics, COVID-19 pandemic, TELEMEDICINE, CHILDREN
Abstract

Background The coronavirus disease 2019 (COVID-19) pandemic has driven a significant increase in the use of telehealth (TH) but little is published about changes in TH usage by pediatric infectious disease (PID) providers. We assessed their pre- and intra-pandemic TH usage and experience. Methods The Pediatric Infectious Diseases Society Telehealth Work Group surveyed PID specialists in the United States and Canada from 6 December 2020 until 26 February 2021. Data collected included TH modalities, barriers, and satisfaction. Results The survey response rate was 11.3% (288 of 2,550 PID clinicians) with 243 (96% of 253 analysis-eligible responses) managing children only. Women accounted for 62.1% (n  = 157), 51.4% (130) of respondents devoted 50–99% of their time to direct patient care, and 93.3% (236) were located in the United States. The greatest increase in TH usage during the pandemic was in synchronous provider–patient communications (3.9-fold increase). During the pandemic, provider–provider TH increased by less than 10%, comfort with TH usage doubled from 42% to 91%, and satisfaction grew from 74% to 93.3% with different aspects of TH. The top challenge was incomplete or no physical examination (182, 71.9%). Multivariate analysis showed that pre-pandemic TH usage and lack of barriers, but not reimbursement, were significantly associated with higher intra-pandemic usage. EMR-integrated TH was associated with significantly higher usage and satisfaction. Over 70% of respondents anticipate continuing TH usage after the pandemic. Conclusions There was high intra-pandemic usage of, and increased comfort and satisfaction with telehealth by PID specialists. Our data help inform post-pandemic TH expectations and strategies. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Isavuconazole Pharmacokinetics and Pharmacodynamics in Children.

Author

Elhence, Hirsh, Mongkolrattanothai, Kanokporn, Mohandas, Sindhu, and Neely, Michael N.

Subjects
DRUG monitoring, PHARMACODYNAMICS, PHARMACOKINETICS, DRUG dosage, CHILD patients, MYCOSES
Abstract

Isavuconazole is a broad-spectrum azole anti-fungal not yet approved in children. We conducted a retrospective, single-center review of isavuconazole use and routine therapeutic drug monitoring in pediatric patients, extracting demographic, dosing, concentration, mortality and hepatoxicity data. We constructed a nonparametric population model using Pmetrics. Of 26 patients, 19 (73%) were male. The mean (SD) age and weight were 12.7 (5.5) years and 50.9 (26.8) kg. Eighty percent received between 9.7 and 10.6 mg/kg per dose. Ten (38%) subjects had proven fungal disease and eight (31%) had probable disease, mostly with Candida and Aspergillus spp. The predicted steady-state isavuconazole concentrations in our patients were similar to previous reports in children and adults, and simulations with the proposed dosing of 10 mg/kg/dose every 8 h for 2 days followed by once daily maintenance matched effective adult exposures. Attributable mortality (5 of 11 deaths) was associated with steady-state daily AUC < 60 mg∗h/L and higher AST/ALT with trough concentrations > 5 mg/L. Neither dose nor trough alone correlated well with AUC, but AUC can be estimated with one sample 10 h after the first maintenance dose or a trough concentration, if combined with a Bayesian approach or a peak and trough without a Bayesian approach. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Colaboradores

Author

Abidi, Nadia Y., Abzug, Mark J., Adams, David R., Adams, Nicholas S., Adelson, Stewart L., Ahlfeld, Shawn K., Ahmad, Osman Z., Aiken, John J., Akdis, Cezmi A., Alessandrini, Evaline A., Alexander, Michael A., Ali, Omar, Anderson, Karl E., Anthony, Kelly K., Antoon, Alia Y., Apkon, Susan D., Ardoin, Stacy P., Arkader, Alexandre, Armangué, Thaís, Arndt, Carola A.S., Aronson, Paul L., Asher, David M., Ashworth, Ann, Assa, Amit, Asselin, Barbara L., Astley, Christina M., Ater, Joann L., Atkinson, Norrell, Augustine, Erika U., Augustyn, Marilyn C., Avitzur, Yaron, Bacino, Carlos A., Bailey, Zinzi D., Balakrishnan, Binod, Balamuth, Frances B., Baldassano, Robert N., Baldwin, Keith D., Bales, Christina, Balistreri, William F., Ballantine, Allison, Baltimore, Robert S., Balwani, Manisha, Bamba, Vaneeta, Banwell, Brenda L., Barclay, Sarah F., Barnes-Davis, Maria E., Barron, Karyl S., Basel, Donald, Bass, Dorsey M., Bassett, Mary T., Bauerfeld, Christian P., Baum, Rebecca A., Bell, Michael J., Bender, Nicole R., Benjamin, Daniel K., Jr, Bennett, Michael J., Bernstein, Daniel, Bernstein, Henry H., Bharucha-Goebel, Diana X., Biggs, Holly M., Blanchard, Samra S., Blatter, Joshua A., Bleyer, Archie, Blum, Nathan J., Boas, Steven R., Bockting, Walter O., Boguniewicz, Mark, Boivin, Michael J., Bonthius, Daniel J., Bordini, Brett J., Bosse, Kristopher R., Bostwick, Bret L., Boyer, Kenneth M., Brady, Jennifer M., Brady, Patrick W., Brady, Rebecca C., Brady, Samuel L., Brandow, Amanda M., Breault, David T., Breuner, Cora Collette, Bridgemohan, Carolyn, Britt, William J., Brower, Laura, Brown, Rebeccah L., Brownell, J. Naylor, Browning, Meghen B., Brunetti-Pierri, Nicola, Bryant, Phillip R., Buckley, Rebecca H., Budek, Cynthia Etzler, Bunyavanich, Supinda, Burnham, Carey-Ann D., Burstein, Gale R., Bustinduy, Amaya L., Buyon, Jill P., Cabada, Miguel M., Cada, Michaela, Caglar, Derya, Cairo, Mitchell S., Calello, Diane P., Camarda, Lauren E., Cameron, Lindsay Hatzenbuehler, Camitta, Bruce M., Campbell, Angela J.P., Carlin, Rebecca F., Carr, Michael R., Carrigan, Robert B., Carroll, Michael S., Carter, Rebecca G., Caserta, Mary T., Chapman, Jennifer I., Cheifetz, Ira M., Chelimsky, Gisela G., Chelimsky, Thomas C., Chemaitilly, Wassim, Chen, Yuan-Tsong, Chiriboga, Jennifer A., Chiu, Yvonne E., Cho, Christine B., Chong, Hey Jin, Chou, Stella T., Christenson, John C., Chun, Robert H., Chusid, Michael J., Cieslak, Theodore J., Claes, Donna J., Clark, Jeff A., Clemens, John David, Coates, Thomas D., Coffin, Susan E., Cohen, Joanna S., Cohen, Mitchell B., Cohen-Wolkowiez, Michael, Colbert, Robert A., Cole, F. Sessions, III, Collaco, J. Michael, Colombo, John L., Congeni, Joseph A., Conner, Lindsay N., Creighton, Sarah M., Crowe, James E., Jr, Czinn, Steven J., Dalal, Aarti S., Dalmau, Josep O., Danziger-Isakov, Lara A., Darville, Toni, Daum, Robert S., Davidson, Loren T., Davidson, Richard S., Davies, H. Dele, Daw, Najat C., Dean, Shannon L., Toro, Helen M. Oquendo Del, DeMaso, David R., Denison, Mark R., Dent, Arlene E., Desnick, Robert J., Deterding, Robin R., Devarajan, Prasad, deVeber, Gabrielle A., Dhar, Vineet, Dhawan, Anil, Dick, André A.S., Dietz, Harry C., III, Diiorio, Daren A., DiMeglio, Linda A., Dixon, Bradley P., Dlamini, Nomazulu, Dodhia, Sonam N., Donohoue, Patricia A., Downes, Kevin J., Doyle, Alexander J., Doyle, Daniel A., Doyle, Jefferson J., Dreskin, Stephen C., Driscoll, Sherilyn W., Dror, Yigal, D'souza, Jill N., Dubowitz, Howard, Dumler, J. Stephen, Duncan, Janet, Dvergsten, Jeffrey A., Earing, Michael G., Eberly, Matthew D., Eddy, S. Derrick, Egan, Marie E., Elder, Jack S., Englander, Elizabeth, Enlow, Elizabeth, Eppes, Stephen C., Ericson, Jessica, Erkan, Elif, Ermias, Yokabed, Eskew, Ashley M., Etzel, Ruth A., Fahrenkopf, Matthew P., Falk, Marni J., Faria, John J., Fargo, John H., Feemster, Kristen A., Feigelman, Susan, Feinstein, Jeffrey A., Feldman, Amy G., Felner, Eric I., Fels, Edward C., Feng, Sing-Yi, Ferkol, Thomas W., Jr, Finberg, Karin E., Finder, Jonathan D., Finkelstein, Laura H., Fiorino, Kristin N., Fischer, Philip R., Fisher, Brian T., Flood, Veronica H., Flores, Francisco X., Flynn, Joseph T., Flynn, Patricia M., Forman, Joel A., Frank, Michael M., Frenck, Robert W., Jr, Friedman, Deborah M., Friehling, Erika, Fritz, Stephanie A., Frush, Donald P., Gadomski, Anne M., Gaensbauer, James T., Gahagan, Sheila, Gahl, William A., Gallagher, Patrick G., Gans, Hayley A., Garcia-mauriño, Cristina, Gardiner, Paula M., Garibaldi, Luigi R., Gauthier, Gregory M., Gerber, Jeffrey S., Gershon, Anne A., Ghadersohi, Saied, Gibson, Mark, Gigliotti, Francis, Gilliam, Walter S., Ginde, Salil, Girotto, John A., Goldfarb, Samuel B., Goldman, David L., Goldman, Stanton C., Goldstein, Neal D., Goldstein, Stuart L., Gonzalez-Heydrich, Joseph, Goodman, Denise M., Goodman, Tracy S., Gordon, Catherine M., Gordon, Leslie B., Goto, Collin S., Gower, W. Adam, Goyal, Neera K., Goyeneche, Nicholas P., Graepel, Kevin W., Graham, Robert J., Greally, John M., Green, Cori M., Green, Michael, Greenbaum, Larry A., Greenbaum, V. Jordan, Greenberg, James M., Griffiths, Anne G., Grizzle, Kenneth L., Groner, Judith A., Guarino, Alfredo, Gurria, Juan P., Guz-Mark, Anat, Haddad, Gabriel G., Haddad, Joseph, Jr, Hagan, Joseph F., Jr, Hagood, James S., Haider, Suraiya K., Haliloglu, Goknur, Halstead, Scott B., Hammer, Allison R., Hammerschlag, Margaret R., Hamvas, Aaron, Harris, James C., Harrison, Douglas J., Hartman, Corina, Hartman, Mary E., Haslam, David B., Hassan, H. Hesham Abdel-Kader, Hauck, Fern R., Havers, Fiona P., Hayes, Ericka V., Hecht, Jacqueline T., Heidemann, Sabrina M., Heimall, Jennifer R., Hemingway, Cheryl, Hendley, J. 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Published
2020
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47. Microbiota control immune regulation in humanized mice

Author

Gülden, Elke, primary, Vudattu, Nalini K., additional, Deng, Songyan, additional, Preston-Hurlburt, Paula, additional, Mamula, Mark, additional, Reed, James C., additional, Mohandas, Sindhu, additional, Herold, Betsy C., additional, Torres, Richard, additional, Vieira, Silvio M., additional, Lim, Bentley, additional, Herazo-Maya, Jose D., additional, Kriegel, Martin, additional, Goodman, Andrew L., additional, Cotsapas, Chris, additional, and Herold, Kevan C., additional

Published
2017
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