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20 results on '"Mohan, Girish"'

1. Malignant syphilis: ostraceous, ulceronecrotic lesions in a patient with human immunodeficiency virus

Author

Mohan, Girish C, Ali, Robert A, Isache, Carmen L, Sharma, Rohit K, and Perniciaro, Charles

Subjects
malignant syphilis, syphilis, doxycycline, lues maligna, HIV
Abstract

We present a 36-year-old HIV-positive man with a sixweek history of spreading, ulcerative, and necroticcutaneous lesions. Laboratory and histopathologicexamination revealed syphilis. This case of malignantsyphilis, also known as lues maligna, is an uncommonvariant of this sexually transmitted infection. This casehighlights the importance of including malignantsyphilis in the differential diagnosis of patientspresenting with a disseminated ulcerative andnecrotic rash, especially in individuals with HIV.

Published
2017

2. A Novel Approach for Security of Data in IoT Environment

Author

Urla, Priyanka Anurag, Mohan, Girish, Tyagi, Sourabh, Pai, Smitha N., Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Peng, Sheng-Lung, editor, Dey, Nilanjan, editor, and Bundele, Mahesh, editor

Published
2019
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13. Challenges in Treating Secondary Syphilis Osteitis in an Immunocompromised Patient with a Penicillin Allergy: Case Report and Review of the Literature

Author

Ali, Robert, Perez-Downes, Julio, Baidoun, Firas, Al Turk, Bashar, Isache, Carmen, Mohan, Girish, and Perniciaro, Charles

Subjects
Article Subject
Abstract

Syphilis is a sexually transmitted infection that remains fairly commonplace. The introduction of penicillin aided in curbing the incidence of disease; however, with the advent of the human immunodeficiency virus (HIV), syphilis is now on a resurgence with sometimes curious presentations. We present a case of a 36-year-old Caucasian gentleman with untreated HIV who complained of a skin eruption and joint pains for 6 weeks, prompting the diagnosis of secondary syphilis osteitis. Skin lesions were reminiscent of “malignant” syphilis. CD4 count was 57 cells/μL. RPR was elevated with 1 : 64 titer and positive confirmatory TP-PA. Radiography of the limbs revealed polyostotic cortical irregularities corroborated on bone scintigraphy. The patient had an unknown penicillin allergy and was unwilling to conduct a trial of penicillin-based therapy. He was subsequently treated with doxycycline 100 mg twice daily for 6 weeks and commenced antiretroviral therapy, noting dramatic improvement in both the skin lesions and joint pains. Unfortunately, he defaulted on follow-up, precluding serial RPR and bone imaging. Penicillin allergies have proven to be quite a conundrum in such patients, without much recourse for alternative therapy. Doxycycline with/without azithromycin is other options worth considering.

Published
2016
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20. Therapeutic Synergy, Neutrality, and Antagonism: Combination Treatment in Dermatology.

Author

Strom MA, Mohan GC, and Lio PA

Subjects
Acne Vulgaris diagnosis, Acne Vulgaris drug therapy, Anti-Bacterial Agents, Dermatitis, Atopic diagnosis, Dermatitis, Atopic drug therapy, Dermatology trends, Drug Synergism, Drug Therapy, Combination, Humans, Lupus Erythematosus, Cutaneous diagnosis, Lupus Erythematosus, Cutaneous drug therapy, Psoriasis diagnosis, Psoriasis drug therapy, Dermatologic Agents administration & dosage, Dermatology methods, Skin Diseases diagnosis, Skin Diseases drug therapy
Abstract

Dermatologists frequently employ combination therapy to treat various diseases, but the evidence to support the use of such combinations is often lacking. Synergy is an appealing although somewhat ambiguous concept in medicine. Utilizing synergy allows clinicians to provide the most efficacious combination of treatments to patients, while potentially minimizing adverse effects and reducing the development of drug resistance. Definitions of synergy vary, but ultimately converge on finding a therapeutic advantage in combining treatments. Here we discuss the concept of 'therapeutic synergy', which can be defined as an increase in the efficacy of a combination of treatments in comparison to any of its individual parts alone. We review the concept of therapeutic synergy in dermatology by discussing some of the evidence regarding combination therapies utilized in the management of atopic dermatitis, acne vulgaris, psoriasis, and cutaneous lupus erythematosus. Further meaningful investigation of therapeutic synergy and its applications in dermatology should be undertaken. , , J Drugs Dermatol. 2016;15(10):1203-1207.

Published
2016

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