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658 results on '"Mohammedi, Kamel"'

14. Differential prognostic burden of cardiovascular disease and lower-limb amputation on the risk of all-cause death in people with long-standing type 1 diabetes

Author

Camoin, Marion, Velho, Gilberto, Saulnier, Pierre-Jean, Potier, Louis, Abouleka, Yawa, Carpentier, Charlyne, Dubois, Severine, Larroumet, Alice, Rigalleau, Vincent, Gand, Elise, Bourron, Olivier, Bordier, Lyse, Scheen, André, Hadjadj, Samy, Roussel, Ronan, Marre, Michel, and Mohammedi, Kamel

Published
2022
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15. Personalized Noninvasive Diagnostic Algorithms Based on Urinary Free Cortisol in ACTH-dependant Cushing's Syndrome.

Author

Lavoillotte, Julie, Mohammedi, Kamel, Salenave, Sylvie, Furnica, Raluca Maria, Maiter, Dominique, Chanson, Philippe, Young, Jacques, and Tabarin, Antoine

Subjects
RECEIVER operating characteristic curves, CUSHING'S syndrome, MAGNETIC resonance imaging, COMPUTED tomography, UNIVERSITY hospitals
Abstract

Context Current guidelines for distinguishing Cushing's disease (CD) from ectopic ACTH secretion (EAS) are questionable, as they use pituitary magnetic resonance imaging (MRI) as first-line investigation for all patients. CRH testing is no longer available, and they suggest performing inferior petrosal sinus sampling (BIPPS), an invasive and rarely available investigation, in many patients. Objective To establish noninvasive personalized diagnostic strategies based on the probability of EAS estimated from simple baseline parameters. Design Retrospective study. Setting University hospitals. Patients Two hundred forty-seven CD and 36 EAS patients evaluated between 2001 and 2023 in 2 French hospitals. A single-center cohort of 105 Belgian patients served as external validation. Results Twenty-four-hour urinary free cortisol (UFC) had the highest area under the receiver operating characteristic curve for discrimination of CD from EAS (.96 [95% confidence interval (CI),.92-.99] in the primary study and.99 [95% CI,.98-1.00] in the validation cohort). The addition of clinical, imaging, and biochemical parameters did not improve EAS prediction over UFC alone, with only BIPPS showing a modest improvement (C-statistic index.99 [95% CI,.97-1.00]). Three groups were defined based on baseline UFC: < 3 (group 1), 3-10 (group 2), and > 10 × the upper limit of normal (group 3), and they were associated with 0%, 6.1%, and 66.7% prevalence of EAS, respectively. Diagnostic approaches performed in our cohort support the use of pituitary MRI alone in group 1, MRI first followed by neck-to-pelvis computed tomography scan (npCT) when negative in group 2, and npCT first followed by pituitary MRI when negative in group 3. When not combined with the CRH test, the desmopressin test has limited diagnostic value. Conclusion UFC accurately predicts EAS and can serve to define personalized and noninvasive diagnostic algorithms. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Skin autofluorescence of advanced glycation end-products relates to new cardiovascular events in type 2 diabetes: A longitudinal observational study

Author

Alkhami, Fadi, primary, Borderie, Gauthier, additional, Foussard, Ninon, additional, Larroumet, Alice, additional, Blanco, Laurence, additional, Barbet-Massin, Marie-Amélie, additional, Ferriere, Amandine, additional, Ducos, Claire, additional, Mohammedi, Kamel, additional, Fawaz, Sami, additional, Couffinhal, Thierry, additional, and Rigalleau, Vincent, additional

Published
2024
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30. Impact of exenatide on weight loss and eating behavior in adults with craniopharyngioma-related obesity: the CRANIOEXE randomized placebo-controlled trial.

Author

Gatta-Cherifi, Blandine, Mohammedi, Kamel, Cariou, Tanguy, Poitou, Christine, Touraine, Philippe, Raverot, Gerald, Brue, Thierry, Chanson, Philippe, Illouz, Frédéric, Grunenwald, Solange, Chabre, Olivier, Sonnet, Emmanuel, Cuny, Thomas, Bertherat, Jerôme, Czernichow, Sébastien, Frison, Eric, and Tabarin, Antoine

Subjects
*WEIGHT loss, *CRANIOPHARYNGIOMA, *GLUCAGON-like peptide 1
Abstract

Importance A major issue in the management of craniopharyngioma-related obesity (CRO) is the ineffectiveness of the current therapeutic approaches. Objective To study the efficacy of glucagon-like peptide-1 analogs compared with placebo in adults with obesity CRO. Design A double-blind multicenter superiority randomized clinical in trial in two parallel arms. Setting Eleven French University Hospital Centers. Participants Adults with CRO (body mass index > 30 kg/m²) without the sign of recurrence of craniopharyngioma in the past year. Interventions Exenatide or placebo injected subcutaneously twice a day during 26 weeks. Main Outcomes and Measures The primary outcome was the mean change in body weight at week 26 in the intention-to-treat population. Secondary outcomes were eating behavior, calories intake, energy expenditure, cardiovascular, metabolic risk factor, quality of life, and the tolerance profile. Results At week 26, weight decreased from baseline by a mean of −3.8 (SD 4.3) kg for exenatide and −1.6 (3.8) kg for placebo. The adjusted mean treatment difference was −3.1 kg (95% confidence interval [CI] −7.0 to 0.7, P = 0.11). Results were compatible with a higher reduction of hunger score with exenatide compared with placebo (estimated treatment difference in change from baseline to week 26: −2.3, 95% CI −4.5 to −0.2), while all other outcomes did not significantly differ between groups. Adverse events were more common with exenatide versus placebo, and occurred in, respectively, 19 (95%) participants (108 events) and 14 (70%) participants (54 events). Conclusions and Relevance Combined with intensive lifestyle interventions, a 26-week treatment with exenatide was not demonstrated superior to placebo to treat craniopharyngioma-related obesity. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Prognostic value of plasma MR-proADM vs NT-proBNP for heart failure in people with type 2 diabetes: the SURDIAGENE prospective study

Author

Fraty, Mathilde, Velho, Gilberto, Gand, Elise, Fumeron, Fréderic, Ragot, Stéphanie, Sosner, Philippe, Mohammedi, Kamel, Gellen, Barnabas, Saulnier, Pierre-Jean, Halimi, Jean-Michel, Montaigne, David, Ducrocq, Grégory, Rehman, Michaela, Marre, Michel, Roussel, Ronan, Hadjadj, Samy, and for the SURDIAGENE Study Group

Published
2018
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39. Persistence of mild hypercortisolism in patients with Cushing's disease treated with cortisol-lowering drugs : the Haircush study

Author

Manon, Fafin, primary, Mohammedi, Kamel, additional, Bertherat, Jerome, additional, Raverot, Gerald, additional, DRUI, Delphine, additional, Yves, Reznik, additional, Castinetti, Frederic, additional, Chanson, Philippe, additional, Corentin, Rouvray, additional, Amandine, Galioot, additional, Brossaud, Julie, additional, and Tabarin, Antoine, additional

Published
2023
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40. Impact of exenatide on weight loss and eating behavior in adults with craniopharyngioma-related obesity: the Cranioexe randomized placebo-controlled trial

Author

Gatta-Cherifi, Blandine, primary, Mohammedi, Kamel, additional, Cariou, Tanguy, additional, Poitou-Bernert, Christine, additional, Touraine, Philippe, additional, Raverot, Gerald, additional, Brue, Thierry, additional, Chanson, Philippe, additional, Illouz, Frederic, additional, Solange, Grunenwald, additional, Chabre, Olivier, additional, Sonnet, Emmanuel, additional, Cuny, Thomas, additional, Bertherat, Jerome, additional, Czernichow, Sebastien, additional, Frison, Eric, additional, and Tabarin, Antoine, additional

Published
2023
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46. Diabetic retinopathy relates to the incidence of foot ulcers and amputations in type 2 diabetes

Author

Borderie, Gauthier, primary, Foussard, Ninon, additional, Larroumet, Alice, additional, Blanco, Laurence, additional, Barbet‐Massin, Marie‐Amélie, additional, Ducos, Claire, additional, Rigo, Marine, additional, Arab, Lila Rami, additional, Domenge, Frédéric, additional, Mohammedi, Kamel, additional, Ducasse, Eric, additional, Caradu, Caroline, additional, Delyfer, Marie‐Noelle, additional, Korobelnik, Jean‐François, additional, and Rigalleau, Vincent, additional

Published
2023
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