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BackgroundAlthough proper latrine utilization is one of the best ways to reduce the risk of infection, it remains a challenge in the majority of rural communities in developing countries such as Ethiopia. Studies have demonstrated the link between individual behavior and latrine use, but there is a paucity of evidence on individual risk perception, perceived social pressure norms, social identity, and perceived ability, which plays an indubitable role in health and behavior change, especially in rural communities.ObjectiveThis study aimed to identify contextual and psychosocial factors associated with latrine utilization among rural communities in Lomabosa district, Ethiopia.MethodsA rural community-based cross-sectional study was conducted in June 2022 among rural households (HHs) in Lomabosa district, Ethiopia. A systematic random sampling method was used to select participant households. Data were collected using a pretested structured questionnaire via face-to-face interviews and on-the-spot observations. Stata version 14.1 software was used for statistical analysis. A binary logistic regression model was used to run the bivariable and multivariable analysis of the data. Variables with p

Abstract Background Cervical cancer is the second most common malignancy in Ethiopia and first in some African countries. It is six times more likely to occur in positive cases of the human immunodeficiency virus than in the general population. If diagnosed and treated early enough, cervical cancer is both treatable and preventable. However, among Ethiopian women who test positive for HIV, the uptake of cervical cancer screening is low. Its determinant factors were not well studied in the study area. Hence, this study was aimed at filling this information gap. Objective To assess uptake of cervical cancer screening services and associated factors among HIV-positive women attending an adult antiretroviral treatment clinic at public hospitals in Addis Ababa, Ethiopia, June 1–30, 2022. Methods A cross-sectional investigation was carried out in a hospital. 407 participants in all were chosen using the systematic sampling technique. A pretested interviewer-administered questionnaire was used to collect the data from respondents. The data were entered into Epi data version 4.6 and exported to SPSS version 25 for analysis. Bivariable and multivariable logistic regression analysis was employed. Adjusted odds ratio with its 95% confidence interval and p value 45 years old (AOR = 0.18, 95% CI: 0.053–0.644), number of children (3 children) (AOR = 0.19, 95% CI:0.036-0.979), perception of being susceptible to cervical cancer (AOR = 6.39, 95% CI: 1.79–22.74), knowledge of cervical cancer and its screening (AOR = 19.34, 95% CI: 7.87–47.75), and positive attitude towards cervical cancer screening (AOR = 8.06, 95% CI:3.62–17.91) were significantly associated factors with the uptake of cervical cancer screening. Conclusion and recommendation in this study, Age > 45 years, having less than three children, feeling susceptible, knowing about cervical cancer and screening, and having a positive attitude toward cervical cancer screening were significant factor of uptake of cervical cancer screening service. There is a need to strengthen the policy and health education on safe sexual practices and healthy lifestyles through information dissemination and communication to scale up screening service utilization.

IntroductionEthiopia has one of the highest maternal death rates in the world, with 412 deaths for every 100,000 live births. A qualified healthcare professional's care during pregnancy, delivery, and the postnatal period is crucial to saving the lives of the mother and her child. The continuum of maternity health services in Ethiopia is still shallow, despite efforts to increase the use of these services. This study's goal was to evaluate the magnitude and factors influencing the entire continuum of care for maternal health services in Chiro City in 2024.MethodsA community-based cross-sectional study was conducted from 15 January to 15 February 2024, among mothers who gave birth in the last year preceding the data collection period in Chiro City, Eastern Ethiopia. Data were collected through face-to-face interviews using a structured questionnaire. Multivariable logistic regression analysis was done to identify determinants of the complete continuum of care. A P-value of

IntroductionEthiopia is one of the countries where persistently high neonatal and maternal mortalities are reported. Preterm prelabor rupture of membrane (PPROM) plays an important contribution to these high mortalities. However, there is a paucity of comprehensive evidence about the epidemiology of PPROM in Ethiopia. Therefore, this systematic review was conducted to assess the pooled prevalence and determinants of PPROM among pregnant women in Ethiopia.MethodsA systematic review and meta-analysis were conducted following the PRISMA guideline. Relevant literatures were searched on African Journals Online (AJOL), PubMed, Scopus, Epistemonikos, CINAHL, Cochrane Library and gray literature. All statistical analyses were performed using STATA 17 software. The random effect meta-analysis model was employed to summarize the pooled estimates. Heterogeneity between included studies was evaluated using I2 statistic. Egger's regression test and Begg's correlation test were employed to assess publication bias, in conjunction with funnel plot. Besides, the non-parametric trim-and-fill analysis, sensitivity analysis, subgroup analysis and meta-regression were also performed.ResultsA total of 13 original studies with 24,386 participants were considered in this systematic review. The pooled prevalence of PPROM was 6.58% (95% CI: 5.36, 7.79). Urinary tract infection (OR: 3.44; 95% CI: 1.81, 6.53), abnormal vaginal discharge (OR: 4.78; 95% CI: 2.85, 8.01), vaginal bleeding (OR: 2.04; 95% CI: 1.03, 4.06), history of PROM (OR: 4.64; 95% CI: 2.71, 7.95), history of abortion (OR: 3.06; 95% CI: 1.71, 5.46), malnutrition (OR: 5.24; 95% CI: 2.63, 10.44), anemia (OR: 3.97; 95% CI: 2.01, 7.85) and gestational diabetes (OR: 5.08; 95% CI: 1.93, 13.36) were significantly associated with PPROM.ConclusionThis meta-analysis found a high prevalence of PPROM in Ethiopia. Urinary tract infection, abnormal vaginal discharge, vaginal bleeding, history of PROM, history of abortion, malnutrition, anemia and gestational diabetes were risk factors for PPROM. Prevention and control of antenatal infections and malnutrition are highly recommended to reduce the magnitude of PPROM in Ethiopia. Additionally, healthcare providers should emphasize the identified risk factors.Protocol registration numberCRD42024536647.

IntroductionBreast cancer continues to be the most common malignancy and the leading cause of cancer-related deaths in Ethiopia. The poor prognosis and high mortality rate of breast cancer patients in the country are largely caused by late-stage diagnosis. Hence, understanding the epidemiology of late-stage diagnosis is essential to address this important problem. However, previous reports in Ethiopia indicated inconsistent findings. Therefore, this literature review was conducted to generate dependable evidence by summarizing the prevalence and determinants of late-stage diagnosis among breast cancer patients in Ethiopia.MethodsPertinent articles were retrieved by systematically searching on major electronic databases and gray literature. Data were extracted into an Excel spreadsheet and analyzed using the STATA 17 statistical software. The pooled estimates were summarized using the random effect meta-analysis model. Heterogeneity and small study effect were evaluated using the I2 statistics and Egger's regression test in conjunction with the funnel plot, respectively. Meta-regression, sub-group analysis, and sensitivity analysis were also employed. Protocol registration number: CRD42024496237.ResultsThe pooled prevalence of late-stage diagnosis after combining reports of 24 studies with 8,677 participants was 65.85 (95% CI: 58.38, 73.32). Residence (adjusted OR: 1.92; 95% CI: 1.45, 2.53), patient delay at their first presentation (adjusted OR: 2.65; 95% CI: 1.56, 4.49), traditional medicine use (adjusted OR: 2.54; 95% CI: 1.89, 3.41), and breast self-examination practice (adjusted OR: 0.28; 95% CI: 0.09, 0.88) were significant determinants of late-stage diagnosis.ConclusionTwo-thirds of breast cancer patients in Ethiopia were diagnosed at an advanced stage. Residence, delay in the first presentation, traditional medicine use, and breast self-examination practice were significantly associated with late-stage diagnosis. Public education about breast cancer and its early detection techniques is crucial to reduce mortality and improve the survival of patients. Besides, improving access to cancer screening services is useful to tackle the disease at its curable stages.

Abstract Background The goal of this work is to assess progression of diabetic macular edema (DME) following intravitreal ranibizumab injection compared to subtenon triamcinolone acetonide injection at cataract operation. Methods Retrospective analysis of 73 eyes of 65 participant with DME, with central macular thickness (CMT) ≥ 300 μm. The included eyes were separated into three groups; phacoemulsification with intravitreal Ranibizumab injection group, phacoemulsification with subtenon Triamcinolone acetonide injection group and phacoemulsification only group. Main measures involved best corrected visual acuity (BCVA) one week, one month and three months post-operative. The CMT was compared preoperative and postoperative (one and three months). Results After 1 month of operation, there was a statistical substantial distinction in the median of CMT between ranibizumab & control group (p

Abstract Background Cervical cancer is the second leading cause of cancer-related death and one of the top 20 causes of death among women in Ethiopia. Cervical cancer screening service has a vital value to reduce morbidity and mortality. Even though cervical cancer screening service utilization in Ethiopia is unacceptably low, its determinant factors were not well studied in the study area. Hence, this study was aimed at filling this information gap. This study aimed to identify determinants of cervical cancer screening service utilization among women attending healthcare services in Amhara region referral hospitals, Ethiopia. Methods Hospital-based case–control study was conducted among 441 women (147 cases and 294 controls) from May to July 2021. Cases were included consecutively and controls were selected using a systematic random sampling technique from the randomly selected hospitals. A pretested interviewer-administered questionnaire was used to collect the data from respondents. The data were entered into Epi data version 4.6 and exported to SPSS version 25 for analysis. Bivariable and multivariable logistic regression analysis was employed. Adjusted odds ratio with its 95% confidence interval and p value

Abstract Background Hepatitis C virus (HCV) is a global public health problem, with ~ 11 million people in Africa infected. There is incomplete information on HCV in Sudan, particularly in haemodialysis patients, who have a higher prevalence compared to the general population. Thus, our objectives were to genotype and molecularly characterize HCV isolated from end-stage renal disease haemodialysis patients. Methods A total of 541 patients were recruited from eight haemodialysis centres in Khartoum and screened for anti-HCV. Viral loads were determined using in-house real-time PCR in seropositive patients. HCV was genotyped and subtyped using sequencing of amplicons of 5′ untranslated (UTR) and non-structural protein 5B (NS5B) regions, followed by phylogenetic analysis of corresponding sequences. Results The HCV seroprevalence in the study was 17% (93/541), with HCV RNA-positive viremic rate of 7% (40/541). A low HCV load, with a mean of 2.85 × 104 IU/ml and a range of 2.95 × 103 to 4.78 × 106 IU/ml, was detected. Phylogenetic analyses showed the presence of genotypes 1, 3, 4, and 5 with subtypes 1a, 1b, 1 g, 3a, 4a, 4 l, 4 m, 4 s, and 4t. Sequences of HCV from the same haemodialysis units, clustered in similar genotypes and subtypes intimating nosocomial infection. Conclusion HCV infection is highly prevalent in haemodialysis patients from Sudan, with phylogenetic analysis intimating nosocomial infection. HCV genotyping is useful to locate potential transmission chains and to enable individualized treatment using highly effective direct-acting antivirals (DAAs).

The aim of the present study was to investigate various biological activities (antimicrobial, anti-Giardial, antimalarial, antitumor, and antioxidant) as well as the phytochemistry of the root, stem, leaves, flowers and fruit of Ludwigia erecta L. The extracts of different plant parts showed variable activity against the tested microorganisms, with the highest activity (p 100 µg/mL), whereas the flower extract showed a cytotoxic effect against the MDA-MB231 cell lines, with an IC50 value of 30.5 ± 2.9 µg/mL. Furthermore, the highest antioxidant activity (p

This study aims to investigate the impact of family business governance (FBG) on organizational innovation (OIN) in family firms operating in Yemen. The study collected data from 219 family firms, and employed PLS-SEM to test the hypotheses and validate the study model. The results provide evidence of the influence of FBG on OIN in family firms, and that the application of FBG practices promotes better results at the organizational level seen as product innovation and process innovation. The results show that there are significant differences in organizational innovation that can be attributed to the size of the firm, while no differences are found to be attributed to the generation in charge. These findings provide a better understanding of the innovativeness in family firms with respect to the different roles of formal and informal governance structures, and may help business families to develop more effective governance structures out of which more active stewards with more innovative ideas can help trigger better organizational innovation. This paper attempts to update the current knowledge concerning inconsistency of findings in prior studies, and so contributes in updating research opportunities with respect to heterogeneity in family firms.

Introduction Epidemiologic research on the types and the distribution of refractive errors (REs) enable efficient planning to improve access to care. Aim The aim was to fill the informational gap concerning the prevalence of REs in different age groups in the Delta region of Egypt and to introduce recommendations and key points for researchers. Patients and methods This is a cross-sectional descriptive study for the prevalence of REs in the Delta region of Egypt among different age groups. The population-based study included 800 eyes of 400 patients from different age groups, 400 eyes in the child age group and 400 eyes in adult age group. Results and discussion The prevalence of myopia was higher than the prevalence of hyperopia. The prevalence of astigmatism was higher than myopia, but also higher than other studies. The prevalence of myopia was higher in the adult age group than in the child age group, which was consistent with that of other East Asian countries. The prevalence of hyperopia was higher in the child age group than in the adult age group. The prevalence of astigmatism was very high and slightly similar in both groups. Conclusion Correcting REs can reduce ophthalmic problems. Improving family awareness and promoting screening programs can be effective in identifying these errors and preventing visual impairment.

The present study was aimed at determining total phenolic and flavonoid contents and studying the antioxidant activity of ginger (Zingiber officinale Rosc.) rhizome and callus, 6-gingerol and 6-shogaol and callus treated with elicitors. Petroleum ether (PE) and chloroform: methanol (1:1, v/v) (CM) extracts were prepared by maceration. Highest total phenolic content was obtained from the CM extract (60.34 ± 0.43 mg gallic acid/g) of rhizome while callus showed lower content detected in the CM extract (33.6 ± 0.07 mg gallic acid/g). Flavonoids were only detected in rhizome (CM extract 40.25 ± 0.21 mg quercetin/g). Both rhizome extracts exhibited good antioxidant activity with higher activity recorded in PE extract (IC50 value 8.29 ± 1.73 μg/mL). Callus extracts revealed lower antioxidant activity (IC50 value 1265.49 ± 59.9 μg/mL obtained from CM extract). 6-gingerol and 6-shogaol displayed high antioxidant activity in both assays with IC50 4.85 + 0.58DPPH and 5.35 ± 0.33ABTS μg/mL for the former and IC50 7.61 ± 0.81DPPH and IC50 7.05 ± 0.23ABTS μg/mL for the latter. Treatment of callus with elicitors showed significant (p

The aim of the current study was to synthesize polyvinyl alcohol Cuprous Oxide composite films (PVA/Cu2O) for radiation detection depending on optical changes. The method adapted from solving of 5% PVA in hot (80 °C) stirred water and after cooling to ambient temperature a 0.5 g of Cu2O dissolved and stirred for 2 h. The films were made by casting in petri dishes contained 20 ml/each. The pealed films were enveloped after drying and receiving radiation doses of 1, 2, 4, 6 … 12 Gy. The analysis revealed a gradient change in color of films from light pink to dark brown with absorption peaks at 215 and 415 nm through entire doses which were increase as dose increment. The optical density of films increases linearly and significantly (R2 = 0.9) as the dose increases from 0.06 (arb. unit) at 1 Gy to 0.4 (a u) at 12 Gy with sensitivity at 0.06 mGy. The energy band gap of the film decreased as the radiation dose increases from 3 × 10−12 to 2 × 10−12 eV. Conclusively; the feasibility of utilizing PVA/Cu2O composite films as radiation detector and personal dosimeter would be applicable in rural sectors and low economic countries. Keywords: PVA, Films, Dosimeters, Cuprous, Radiation, Optical

To report the causes of childhood-onset uveitis in a tertiary pediatric ophthalmology hospital in Egypt. Retrospective study of the medical records of all uveitis patients following up at a tertiary pediatric ophthalmology hospital in Egypt from January 2017 to December 2020. The present study included 388 patients. The most common anatomical category was intermediate uveitis (30.4%), and around half of these children had pars planitis. This was followed by panuveitis (25.5%), posterior uveitis (23.5%), and anterior uveitis (20.6%), in decreasing frequency. Juvenile idiopathic arthritis, toxoplasmosis, and Vogt–Koyanagi–Harada syndrome were the most common causes of anterior uveitis, posterior uveitis, and panuveitis respectively. Cataract (40.5%), glaucoma (33.8%), and cystoid macular edema (31.6%) were the most frequent ocular complications. The present report provides the relative prevalence of the different anatomical types of uveitis, as well as their main causes in a cohort of Egyptian patients with childhood-onset uveitis. [ABSTRACT FROM AUTHOR]

In this paper, we describe an approach to analyze 2D truss/Frame/Beam structures under Flash-based environment. Stiffness Matrix Method (SMM) module was developed as part of ongoing projects on a broad topic "Students' Learning Improvements in Science, Technology, Engineering and Mathematics (STEM) Related Areas" at Old Dominion University (ODU), and funded by National Science Foundation (NSF). In this internet web based simulation, 2D Civil Engineering models for Truss, Frame and Beam structures can be created and analyzed with appropriately specified material properties, boundary conditions, and loads. The entire process for creating and analyzing structural models can be done online with user friendly web based tools. The module can be viewed at http://www.lions.odu.edu/~amoha006. Tutorials and demonstrated movies of the actual implementation of the models should make learners/users more comfortable. Theoretical description provides detail explanation of the theories behind the developed module. After the analysis is completed, the deflected shape of the structure and its' member stress intensities are also plotted. A self-assessment test module was developed which automatically grades the student's answers by comparing them with the computer generated solutions. The student's graded test score and the corresponding correct answers were automatically sent back to both the instructor and student through their email addresses. A survey was conducted between two classes in Spring '07 (without students being exposed to the developed SMM module) and Spring '08 (with SMM module) in Structural Analysis-I course at ODU. Preliminary results from the surveys have indicated that significant improvements in students' performance have been realized through the developed on-line SMM module. (Contains 2 tables and 9 figures.)