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Iran hosts more than 350 Precambrian to Cenozoic sediment-hosted Zn-Pb±Ba and barite-sulfide deposits, including shale-hosted massive sulfide (SHMS, also called SEDEX) and Irish-type and Mississippi Valley-type (MVT) mineralization, and barite is a common mineral in these deposits. In the SHMS deposits, barite is typically found as fine-grained disseminations in thin laminae. In these deposits, the sulfide laminae often occur as diagenetic replacements and as bands containing authigenic and diagenetic barite and pyrite framboids. In the Irish-type Zn-Pb-Ba and stratabound barite-sulfide deposits, barite exhibits various textures, including fine-grained disseminated barite, banded zebra textures, veins, and massive barite lenses. In some of the giant Irish-type deposits, as well as in the stratabound barite-sulfide mineralization, the main stratabound sulfide ore is developed within a barite envelope and is characterized by the replacement of barite and pyrite by chalcopyrite, galena, and sphalerite. In the MVT deposits, the formation of barite is often related to dolomitization, and sulfide mineralization involves the replacement of the dolomitized carbonate rocks, as well as associated barite. Fluid inclusion studies on the Irish-type deposits indicate that the temperatures and salinities of the sulfide-forming fluids are higher compared to those of the barite-forming fluids. Fluid inclusion analyses of coarse-grained barites from Irish and MVT deposits reveal their hydrothermal origin. The δ3⁴S values of sulfide minerals (pyrite, sphalerite, and galena) in Irish-type deposits exhibit a broad range of low values (mostly −28 to +5‰), primarily revealing a process of bacterial sulfate reduction (BSR). However, the textures (replacement, colloform, and banded) and more positive sulfur isotope values (+1 to +36‰) in the SHMS Zn-Pb deposits suggest that bacterial sulfate reduction (BSR) plays a less significant role. We suggest that thermochemical sulfate reduction (TSR) connected to the direct replacement of barite plays a more relevant role in providing sulfur for the sulfide mineralization in the SHMS, barite-sulfide, and MVT deposits. Based on the textual evidence, sulfur isotopic data, and fluid inclusion studies, barite has been identified as a key controller for the subsequent Zn-Pb mineralization by providing a suitable host and significant sulfur contribution in the sediment-hosted Zn-Pb and stratabound barite-sulfide deposits. This implies that diagenetic barite might be a precursor to all types of sediment-hosted Zn-Pb mineralization. [ABSTRACT FROM AUTHOR]

Objective: In late 2019, with the outbreak of Covid 19, China began the first level of public health and emergency response. "Internet plus nursing services" is registered for the use of nurses in medical centers based on information technology "online program, offline services", which refers to the provision of nursing services for home patients or patients after discharge. The purpose of this article is to classify and identify information technology that facilitates nursing processes. Methods: This research is an applied study that was conducted in 1399 by systematic review method. Using the keywords of information technology, nurses, nursing process, corona virus and COVID-19were performed in various databases such as PubMed, ScienceDirect and Google scholar in the last two years from early 2019 to the end of 2020 (2020-2019). Results: In this study, 211 English articles were found which were included in the study after reviewing 9 articles. The most satisfactory platform from the users' point of view (91%) The IT platform for "Internet plus nursing services" is a Wechat mini program that was developed and used in early 2019. Conclusion: Prior to the COVID-19 epidemic, "Internet plus nursing services" was performed using online appointments and offline home visits to provide nursing services to patients. [ABSTRACT FROM AUTHOR]

The flavonoid quercetin has recently been reported to have neuroprotective effects, and the role of the gamma-aminobutyric acid A alpha 5 subunit (GABA.sub.A [alpha]5) receptor has been determined in some nervous system disorders. The aim of this study was to identify the molecular mechanism of the effect of quercetin administered at anticonvulsive doses on the expression of the GABA.sub.A [alpha]5 receptor gene in kainic acid (KA)-induced seizures in mice. The experimental animals were divided into four groups: control, KA, and KA + quercetin at 50 or 100 mg/kg, respectively. The results showed a dose-dependent reduction in the behavioral seizure score with quercetin pre-treatment in the KA mouse model. Two hours after the end of the 7-day treatment regimen, expression of the GABA.sub.A [alpha]5 receptor gene in the hippocampus was found to be increased in the KA group, but this increase was reduced in the KA + quercetin 50 or 100 mg/kg treatment groups. These results suggest that expression of the GABA.sub.A [alpha]5 receptor could be a mechanism for reducing seizure severity or may be a marker of seizure severity. Further studies are necessary to clarify quercetin's mechanism of action and the relation of GABA.sub.A [alpha]5 receptor gene expression to seizure severity. Keywords: Quercetin, Seizure, GABA.sub.A [alpha]5 subunit, Gene expression, Author(s): Sahar Moghbelinejad[sup.1], Safar Alizadeh[sup.1], Ghazaleh Mohammadi[sup.2], Fatemeh Khodabandehloo[sup.2], Zahra Rashvand[sup.1], Reza Najafipour[sup.1] and Marjan Nassiri-Asl[sup.1,3] Introduction Epilepsy is one of the most common neurological disorders and affects approximately 1 [...]

Objective: The role of gut microbiota in the pathogenesis of several neurodegenerative disorders, including Alzheimer's disease (AD), via the gut-brain axis has recently been demonstrated; hence, modification of the intestinal microbiota composition by probiotic biotherapy could be a therapeutic target for these conditions. The aim of this study was to assess the effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) on inflammatory and memory processes in lipopolysaccharide (LPS)-induced rats, one of the animal models used in peripherally induced neuroinflammation and neurodegeneration.Methods: Rats were randomly divided into four groups (Control, LPS, Probiotic + LPS, and Probiotic). All experimental groups were orally administrated maltodextrin (placebo) or probiotic (109 CFU/ml/rat) for 14 consecutive days and then were injected with saline or LPS (1 mg/kg, intraperitoneally [i.p.], single dose) 20 hours later. Memory retention ability and systemic and neuroinflammatory markers were assessed 4 hours after the injections.Results: Systemic exposure to LPS resulted in significant elevation of both the circulating and hippocampal levels of proinflammatory cytokines, which decreased remarkably following probiotic pretreatment. Oral bacteriotherapy with a combination of L. helveticus R0052 and B. longum R0175 also attenuated the decremental effect of LPS on memory through brain-derived neurotrophic factor (BDNF) expression at the molecular level; however, this effect was not significant in the passive avoidance test at the behavioral level.Conclusions: These results suggest that the management of gut microbiota with this probiotic formulation could be a promising intervention to improve neuroinflammation-associated disorders such as AD. [ABSTRACT FROM AUTHOR]

An abstract of the study "The Effects of Wet Cupping on Serum High-Sensitivity C- Reactive Protein and Heat Shock Protein 27 Antibody Titers in Patients With Metabolic Syndrome" by Alexandra Dimitrova, Jau-Shin Lou, Sarah Andrea, Yunpeng Luo, Charles Murchison and Barry Oken is presented.