27 results on '"Mohammad Vahidi"'
Search Results
2. The Effectiveness of Emotion Regulation Training on Metacognitive Beliefs and Pain Perception in Patients with Functional Indigestion
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Leila Ahmadkhani, Mohammad Vahidi, Maral Khosravi, Samira Dehghan-Khalili, and Zohreh Zadhasan
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Medicine (General) ,R5-920 - Abstract
Background: The most common gastrointestinal disorders are functional gastrointestinal disorders (FGID) of which functional indigestion is one of the most common types and causes the deterioration of health and reduction of quality of life (QOL). This study was conducted with the aim to determine the effectiveness of emotion regulation training on metacognitive beliefs and pain perception in patients with functional indigestion. Methods: The present study was a quasi-experimental research with pretest-posttest design and a control group. The statistical population consisted of all patients with functional indigestion in Tehran, Iran, in 2020. The sample consisted of 30 patients who were selected through the convenience sampling method and randomly assigned to an experimental group (emotion regulation training) and a control group (each consisting of 15 people). The research tools included the Metacognitions Questionnaire (Wells & Cartwright-Hatton, 2004) and McGill Pain Questionnaire (Melzack, 1975). Data analysis was performed using analysis of variance in SPSS software. Results: The findings showed that emotion regulation training was effective on metacognitive beliefs (P < 0.001) and pain perception (P < 0.001) in patients with functional indigestion. Conclusion: It can be concluded that emotion regulation training was effective on metacognitive beliefs and pain perception in patients with functional indigestion.
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- 2021
3. Macrosomia is a risk factor for incident maternal chronic kidney disease
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Mohammad Vahidi, Samaneh Asgari, Maryam Tohidi, Fereidoun Azizi, and Farzad Hadaegh
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Chronic kidney disease ,Gestational diabetes mellitus ,Macrosomia ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Gestational diabetes mellitus (GDM) and macrosomia are associated with several adverse outcomes including diabetes mellitus and cardiovascular diseases, however, the relationship between GDM/macrosomia with incident chronic kidney disease (CKD) is a matter of debate. The purpose of this study was to examine the association between the history of macrosomia with or without GDM and incident maternal CKD. Methods The study population includes 2669 women aged 18–50 years without known diabetes mellitus and CKD from participants of the Tehran Lipid and Glucose Study. The study population was categorized into 3 groups; group 1: GDM/macrosomia and without diabetes mellitus (n = 204), group 2: newly diagnosed incident diabetes mellitus (NDM) in the presence or abcence of GDM/Macrosomia (n = 113), and, group 3: the reference group including women without prior history of GDM/macrosomia and free of NDM (n = 2352). CKD was defined as an estimated glomerular filtration rate (eGFR)
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- 2021
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4. COVID-19 and ICU admission associated predictive factors in Iranian patients
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Amir Sadeghi, Pegah Eslami, Arash Dooghaie moghadam, Ali Pirsalehi, Sajad Shojaee, Mohammad Vahidi, Amirali Soheili, Faezeh Ghanimat, Yasaman Keshmiri, Saeed Abdi, and Mohammad Reza Zali
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icu admission ,covid-19 ,prognostic factors. ,Internal medicine ,RC31-1245 - Abstract
Background: The pandemic situation created an overwhelmed needs for ICU facilities, according to this problem, the need of accurate the management of facilities represents bold. In this study, prognostic risk factors for ICU admission among COVID-19 hospitalized patients were evaluated. Methods: From 22 February to April 20, 2020. Totally,214 COVID-19 patients participated in this study. The included patients were between 18- 80 years old, and the patients who previously admitted for COVID-19 were excluded. The comorbid medical conditions, admission laboratory, demographic data, and first manifestations were analyzed between two groups, including ICU and non-ICU admitted patients. The statistical analysis, univariate and multivariate analysis were afforded. The value of the predictors in risk assessment of ICU admission were estimated. Results: 55 patients (25.7%) were admitted in ICU. The ICU admitted patient’s mortality rate was about 68%. The age was significantly higher among ICU admission group (P=0.03). Admission O2 saturation was significantly lower among ICU admitted patients (P=0.00). The kidney disease and malignancy history were more frequent in ICU-admitted patients (P=0.04, P=0.00). Myalgia was the clinical manifestation that significantly presented more frequent in ICU-admitted patients. INR, CRP, ESR, HB, and Lymphocyte were significantly different between two groups. After multivariable analysis, admission O2 saturation, hematocrit, CRP and myalgia could significantly predict the risk of ICU admission. Furthermore, the value of predictors was estimated in our study. Conclusion: Based on our results, the admission O2 saturation, HCT, CRP levels at first admission and myalgia presentation could be considered as the valuable predictors of ICU admission.
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- 2020
5. Identify the Attitudes and Mentality Existing in the Field of Jihadi Management (Case Study: Imam Khomeini Relief Committee Managers)
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Mohammad Vahidi, Abbasali Rastgar, and seyed abbas Ebrahimi
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attitudes ,mentality ,jihadist management ,q method ,relief foundation directors ,Islam ,BP1-253 ,Management. Industrial management ,HD28-70 - Abstract
Jihadist management is a new model of management ideas developed after the Iran’s Islamic Revolution. Management, which has been able to open up new windows into the country's management system through the use of the art and management science and applying Islamic concepts. The purpose of this research is to investigate the challenges of jihad management. In this research, the Q method has been used. The participants of this research were 10 members of the Imam Khomeini Relief Foundation directors who had direct relevance to the research. discourse space of the present study was gathered from a variety of sources. After evaluating and summarizing the discourse space, out of 197 Quo's terms, at last, 70 sentences were as the sample of (Q's category), followed by a survey of experts. Data gathering from Q sorting, this information was analyzed by Q Factor Analysis Method. The distribution analysis showed that four distinct mental patterns could be identified among the participants in the research on the factors influencing the identification of the challenges of jihad management. Finally, 74.91% of the total variance was explained. These four subjective patterns were named according to the names of Necessary requirements: behavioral requirements, approach requirements, basic requirements.
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- 2020
6. The Effectiveness of Mindfulness-Based Cognitive Therapy on Life Expectancy and Depression in Patients with Multiple Sclerosis
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Shirin Haji-Adineh, Atieh Farzanfar, Shahnaz Salehi-Morekani, Mohammad Vahidi, and Maryam Kalhornia-Golkar
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mindfulness-based cognitive therapy ,life expectancy ,depression ,multiple sclerosis ,Medicine (General) ,R5-920 - Abstract
Background: Multiple sclerosis (MS) is one of the most common diseases of the central nervous system (CNS) that can affect life expectancy and depression in patients suffering from this disease. The aim of this study was to determine the effectiveness of mindfulness-based cognitive therapy (MBCT) on life expectancy and depression in patients with MS.Methods: The study adopted a pretest-posttest research design with a control group. The statistical population included all patients with MS enrolled in the MS Society of Tehran, Iran, from 2009 to 2016. Using simple random sampling, 30 subjects were assigned to two experimental and control groups. The research tools included the Life Expectancy Questionnaire (LEQ) and Beck Depression Inventory (BDI). Data were analyzed using univariate analysis of covariance in SPSS software.Results: MBCT training led to significantly higher life expectancy in the experimental group with a greater mean life expectancy in the experimental group than the control group (P < 0.01; F = 42.22). Moreover, MBCT training reduced depression in the experimental group with a higher mean depression score than that of the control group (P < 0.0001; F = 22.53).Conclusion: It can be concluded that MBCT training increased life expectancy and decreased depression in the experimental group.
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- 2019
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7. Neurological Manifestations and their Correlated Factors in COVID-19 Patients; a Cross-Sectional Study
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Farzad Ashrafi, Davood Ommi, Alireza Zali, Sina Khani, Amirali Soheili, Mehran Arab-Ahmadi, Behdad Behnam, Shabnam Nohesara, Farbod Semnani, Alireza Fatemi, Mehri Salari, Reza Jalili khoshnood, Mohammad Vahidi, Niloofar Ayoobi-Yazdi, Saeed Hosseini Toudeshki, and Elham Sobhrakhshankhah
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COVID-19 ,Neurologic Manifestations ,Blood cell count ,Risk Factors ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Introduction: COVID-19 might present with other seemingly unrelated manifestations; for instance, neurological symptoms. This study aimed to evaluate the neurologic manifestations and their correlated factors in COVID-19 patients. Methods: This retrospective observational study was conducted from March 17, 2020 to June 20, 2020 in a tertiary hospital in Iran. The study population consisted of adult patients with a positive result for COVID-19 real-time reverse transcriptase polymerase chain reaction (RT-PCR) using nasopharyngeal swabs. Both written and electronic data regarding baseline characteristic, laboratory findings, and neurological manifestations were evaluated and reported. Results: 727 COVID-19 patients with the mean age of 49.94 ± 17.49 years were studied (56.9% male). At least one neurological symptom was observed in 403 (55.4%) cases. Headache (29.0%), and smell (22.3%) and taste (22.0%) impairment were the most prevalent neurological symptoms, while seizure (1.1%) and stroke (2.3%) were the least common ones. Patients with neurological manifestations were significantly older (p = 0.04), had greater body mass index (BMI) (p = 0.02), longer first symptom to admission duration (p < 0.001) and were more frequently opium users (p = 0.03) compared to COVID-19 patients without neurological symptoms. O2 saturation was significantly lower in patients with neurological manifestations (p = 0.04). In addition, medians of neutrophil count (p = 0.006), neutrophil-lymphocyte ratio (NLR) (p = 0.02) and c-reactive protein (CRP) (p = 0.001) were significantly higher and the median of lymphocyte count (p = 0.03) was significantly lower in patients with neurological manifestations. Conclusion: The prevalence of neurological manifestations in the studied cases was high (55.4%). This prevalence was significantly higher in older age, grated BMI, longer lasting disease, and opium usage.
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- 2021
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8. Neutrophil-to-lymphocyte ratio (NLR) greater than 6.5 may reflect the progression of COVID-19 towards an unfavorable clinical outcome
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Ali Pirsalehi, Sina Salari, Ahmadreza Baghestani, Mohammad Vahidi, Laya Jalilian Khave, Mohammad Esmaeil Akbari, and Davood Bashash
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COVID-19 ,SARS-CoV-2 ,Prognosis ,Neutrophil-to-lymphocyte ratio ,Hematological parameters ,Microbiology ,QR1-502 - Abstract
Background and Objectives: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was first described during a pneumonia outbreak in Wuhan, has attracted tremendous attention in a short period of time as the death toll and the number of confirmed cases is growing unceasingly. Although molecular testing is the gold standard method of SARS-CoV-2 detection, the existence of the false-negative results presents a major limitation to this method. Materials and Methods: This retrospective Double-Centre study was conducted on 1320 COVID-19 patients recruited at Taleghani and Shohadae Tajrish Hospitals in Tehran, Iran. We analyzed the leukocyte, lymphocyte and neutrophil counts of hospitalized cases both on admission and at discharge. We also evaluated the alteration of these parameters within a seven-day follow-up. Results: Of the whole, 1077 (81.6%) neither were admitted to intensive care unit (ICU) nor experienced death, and were defined as the mild-moderate group. Of 243 severe cases, while 59 (24.3%) were admitted to ICU and cured with the intensive care services, 184 (75.7%) patients died of the disease, either with or without ICU admission. Calculation of neutrophil-to-lymphocyte ratio (NLR) revealed that the mild-moderate cases had a lower ratio at discharge. On the other hand, the ratio was significantly higher in the death group as compared to the ICU group; highlighting the fact that patients with a higher degree of neutrophilia and a greater level of lymphopenia have a poor prognosis. Conclusion: We suggest that NLR greater than 6.5 may reflect the progression of the disease towards an unfavorable clinical outcome, with this notion that the ratios higher than 9 may strongly result in death.
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- 2020
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9. Student-Led Initiatives’ Potential in the COVID-19 Response in Iran
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Mohammad Vahidi, Laya Jalilian Khave, Ghazal Sanadgol, Dorsa Shirini, and Mohammad Karamouzian
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covid-19 ,pandemic ,medical students ,non-governmental organization (ngo) ,iran ,Public aspects of medicine ,RA1-1270 - Published
- 2020
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10. Science in Society; from Monologue to Dialogue
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Mohammad Vahidi
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dialogue ,participation ,public engagement in science and technology ,public understanding of science and technology ,science communication ,scientific literacy ,Social sciences (General) ,H1-99 - Abstract
The goal of this paper is to show that, as in other fields of humanities and social studies, there has been a shift from monologue to dialogue in the course of the history of “science, technology, and society” studies. The paper discusses the topic by reconsideration of key paradigms of science and society studies, such as scientific literacy, public understanding of science and technology etc. During this paradigm evolution, it has been gradually accepted that up-down models of Science Communication, which assume public as suffering from knowledge deficit, do not work even to improve the public support of science. The outcome of related debates in the recent half-century, according to the paper, was that science and society should participate in a proper, immediate, and equivalent dialogue. The paper supports this conclusion by review of studies that documented and analyzed the history of studies and initiatives of “science, technology, and society”
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- 2009
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11. Experimental and numerical investigation of debonding in the composite sandwich structures with a foam-composite core under TPSB test
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Mohammad Vahidi Bidhendi, Gholam Hosein Rahimi, Mohammad Sajjad Gazor, and Amir Reza Zangoei
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Mechanical Engineering ,Applied Mathematics ,Automotive Engineering ,General Engineering ,Aerospace Engineering ,Industrial and Manufacturing Engineering - Published
- 2022
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12. Prognostic Factors Associated with Survival in Patients Infected with COVID-19: A Retrospective Study on 214 Patients from Iran
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Mohammad Vahidi, Pegah Eslami, Fateme Feizollahi, Amir Sadeghi, Arash Dooghaie Moghadam, Saba Ilkhani, Bobak Moazzami, Sepideh Banar, Maryam Nasserinejad, Saeed Abdi, Ali Pirsalehi, Mohammad Reza Zali, and Hamid Asadzadeh Aghdaei
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Adult ,Male ,medicine.medical_specialty ,Clinical Decision-Making ,Population ,Context (language use) ,Iran ,law.invention ,Risk Factors ,law ,Internal medicine ,Epidemiology ,Humans ,Medicine ,Hospital Mortality ,education ,Aged ,Proportional Hazards Models ,Retrospective Studies ,education.field_of_study ,business.industry ,Proportional hazards model ,Mortality rate ,Age Factors ,COVID-19 ,Retrospective cohort study ,General Medicine ,Middle Aged ,Prognosis ,Intensive care unit ,Hospitalization ,Survival Rate ,Population study ,Female ,business - Abstract
BACKGROUND: Decision-making on allocating scarce medical resources is crucial in the context of a strong health system reaction to the coronavirus disease 2019 (COVID-19) pandemic. Therefore, understanding the risk factors related to a high mortality rate can enable the physicians for a better decision-making process. METHODS: Information was collected regarding clinical, demographic, and epidemiological features of the definite COVID-19 cases. Through Cox regression and statistical analysis, the risk factors related to mortality were determined. The Kaplan-Meier curve was used to estimate survival function and measure the mean length of living time in the patients. RESULTS: Among about 3000 patients admitted in the Taleghani hospital as outpatients with suspicious signs and symptoms of COVID-19 in 2 months, 214 people were confirmed positive for this virus using the polymerase chain reaction (PCR) technique. Median time to death was 30 days. In this population, 24.29% of the patients died and 24.76% of them were admitted to the ICU (intensive care unit) during hospitalization. The results of Multivariate Cox regression Analysis showed that factors including age (HR, 1.031; 95% CI, 1.001-1.062; P value=0.04), and C-reactive protein (CRP) (HR, 1.007; 95% CI, 1.000-1.015; P value=0.04) could independently predict mortality. Furthermore, the results showed that age above 59 years directly increased mortality rate and decreased survival among our study population. CONCLUSION: Predictor factors play an important role in decisions on public health policy-making. Our findings suggested that advanced age and CRP were independent mortality rate predictors in the admitted patients.
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- 2021
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13. Macrosomia is a risk factor for incident maternal chronic kidney disease
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Maryam Tohidi, Mohammad Vahidi, Farzad Hadaegh, Fereidoun Azizi, and Samaneh Asgari
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Adult ,Gestational hypertension ,medicine.medical_specialty ,endocrine system diseases ,Pregnancy, High-Risk ,030209 endocrinology & metabolism ,Iran ,Macrosomia ,Kidney Function Tests ,Risk Assessment ,Gestational diabetes mellitus ,lcsh:Gynecology and obstetrics ,Body Mass Index ,Fetal Macrosomia ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Risk Factors ,Diabetes mellitus ,Chronic kidney disease ,medicine ,Humans ,030212 general & internal medicine ,Renal Insufficiency, Chronic ,Family history ,Risk factor ,lcsh:RG1-991 ,Obstetrics ,business.industry ,Incidence ,Smoking ,Hazard ratio ,Obstetrics and Gynecology ,nutritional and metabolic diseases ,Prenatal Care ,Hypertension, Pregnancy-Induced ,medicine.disease ,female genital diseases and pregnancy complications ,Gestational diabetes ,Diabetes, Gestational ,Female ,business ,Body mass index ,Maternal Age ,Research Article ,Kidney disease - Abstract
Background Gestational diabetes mellitus (GDM) and macrosomia are associated with several adverse outcomes including diabetes mellitus and cardiovascular diseases, however, the relationship between GDM/macrosomia with incident chronic kidney disease (CKD) is a matter of debate. The purpose of this study was to examine the association between the history of macrosomia with or without GDM and incident maternal CKD. Methods The study population includes 2669 women aged 18–50 years without known diabetes mellitus and CKD from participants of the Tehran Lipid and Glucose Study. The study population was categorized into 3 groups; group 1: GDM/macrosomia and without diabetes mellitus (n = 204), group 2: newly diagnosed incident diabetes mellitus (NDM) in the presence or abcence of GDM/Macrosomia (n = 113), and, group 3: the reference group including women without prior history of GDM/macrosomia and free of NDM (n = 2352). CKD was defined as an estimated glomerular filtration rate (eGFR) 2. Multivariable Cox proportional hazard regression adjusted for baseline values of age, body mass index, waist circumference, parity numbers, smoking, educational level, gestational hypertension, eGFR, systolic and diastolic blood pressures (SBP and DBP, respectively), anti-hypertensive medication, and family history of diabetes mellitus was applied for data analyses. Results During a median follow-up of 11.9 years, 613 incident CKD cases were identified. The multivariable hazard ratio (HR) and 95% confidence interval (CI) on GDM/macrosomia group was [1.32 (1.02–1.72)]; the risk was more prominent among non-hypertensive women [1.41 (1.07–1.85); P for interaction: 0.046]. Moreover, the history of macrosomia alone also showed a significant risk [1.36 (1.04–1.78)]; however, history of GDM alone did not have a significant risk [0.92 (0.34–2.46)]. Age, current smoking, eGFR, and SBP remained as independent risk factors for incident CKD. Conclusions A history of GDM/macrosomia or macrosomia alone, independent of subsequent diabetes mellitus was associated with significant risk for incident maternal CKD. Pregnancy may provide a unique situation to identify high-risk women at risk for CKD that could benefit from regular monitoring of kidney function and providing risk modifying strategies.
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- 2021
14. COVID-19-related strokes in adults below 55 years of age: a case series
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Alireza Zali, Mohammad Vahidi, Arash Azhideh, Soroor Advani, Mehran Arab-Ahmadi, Reza Jalili Khoshnood, Behdad Behnam, Mehri Salari, Alireza Fatemi, Davood Ommi, Farzad Ashrafi, and Maryam Yousefi-Asl
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Adult ,Male ,myalgia ,medicine.medical_specialty ,Neurology ,Pneumonia, Viral ,Clinical Neurology ,Dermatology ,Disease ,Neurological manifestation ,Betacoronavirus ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Pandemics ,Stroke ,Neuroradiology ,SARS-CoV-2 ,business.industry ,Respiratory disease ,COVID-19 ,General Medicine ,Middle Aged ,medicine.disease ,Coronavirus ,Psychiatry and Mental health ,Etiology ,Female ,Neurology (clinical) ,Neurosurgery ,medicine.symptom ,Coronavirus Infections ,business ,030217 neurology & neurosurgery - Abstract
Background Coronavirus infection is a novel respiratory disease affecting people across the world. Although the majority of patients present with fever, dyspnea, cough, or myalgia, various signs and symptoms have been reported for this disease. Recently, neurological symptoms have been noticed in patients with COVID-19 with unknown etiology. However, the occurrence of strokes in young and middle aged patients with COVID-19 is not fully explained. Methods In this series, six patients younger than 55 years of age with diagnosis of stroke and a confirmed diagnosis of COVID-19 were evaluated for symptoms, lab data, imaging findings, and outcomes from March 2020 to the end of April 2020 from all stroke cases in a tertiary academic hospital. Patients older than 55 and all others who had evidence of cardiac abnormalities (arrhythmia/valvular) were excluded. Results Fever, myalgia, cough, and dyspnea were the most common clinical symptoms noted in 66.66% (4/6), 66.66% (4/6), 50% (3/6), and 50% (3/6) of the patients, respectively. The mean ± standard deviation (SD) of National Institutes of Health Stroke Scale (NIHSS) for the patient was 10.16 ± 7.13 (ranged 5–24). The most involved area was middle cerebral artery (MCA) (five in MCA versus one in basal ganglia) and the majority of our patients had a low lung involvement score (mean ± SD: 13.16 ± 6.49 out of 24). Finally, one patient was deceased and rest discharged. Conclusion Stroke may be unrelated to age and the extent of lung involvement. However, different factors may play roles in co-occurrence of stroke and COVID-19 and its outcome. Future studies with long-term follow-up and more cases are needed to assess prognostic factors.
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- 2020
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15. The Role of Inflammatory Factors in the Covid-19 Disease
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Eslami, Fesharaki Mj, Mohammad Vahidi, Sandgol G, B. Rezaei, Dorsa Shirini, Gharaei B, Saeed Abdi, and Ali Pirsalehi
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Coronavirus disease 2019 (COVID-19) ,business.industry ,Immunology ,Medicine ,Inflammatory factors ,Disease ,business - Abstract
Late in 2019 a new pandemic was caused by a novel coronavirus which was later named as Covid-19 by WHO. Regarding the unknown behavior of the disease finding some predicting factors was important so it could be possible to curb the mortality and morbidity risk of the disease. Later studies showed the important role of inflammatory factors in the process of the disease. In this retrospective, multicenter study, 1199 adult patients were randomly selected. Patients were divided to three main groups: Severe/Moderate, ICU add/Non- ICU add and Expired/Alive. The clinical data (including heart rate, respiratory rate, systolic blood pressure and diastolic blood pressure) and the laboratory findings (including NLR, PLR, D-dimer, Troponin, and CRP) of their first date of admission were studied from their documents. The mean of each factor was compared within each group and the binary logistic regression was done for each factor. ROC curves were drawn separately based on the results of the binary logistic regression analysis (P-value
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- 2021
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16. Clinical and Epidemiological Characteristics of Postdischarge Patients With COVID-19 in Tehran, Iran: Protocol for a Prospective Cohort Study (Tele-COVID-19 Study)
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Laya Jalilian Khave, Minoosh Shabani Barzegar, Reza Jalili Khoshnood, Davood Ommi, Alireza Fatemi, Ehsan Masarat, Dorsa Shirini, Mostafa Shokoohi, Alireza Zali, Mohammad Karamouzian, Ali Pirsalehi, Saeed Abdi, Taha Hassanzadeh, Farzad Ashrafi, Behandokht Rezaei, Ghazal Sanadgol, Shabnam Nohesara, Mohammad Vahidi, and Mehran Arab-Ahmadi
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health care delivery ,medicine.medical_specialty ,Telemedicine ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Iran ,01 natural sciences ,03 medical and health sciences ,0302 clinical medicine ,cohort studies ,Medical advice ,Epidemiology ,medicine ,Protocol ,030212 general & internal medicine ,0101 mathematics ,Prospective cohort study ,Response rate (survey) ,business.industry ,010102 general mathematics ,COVID-19 ,General Medicine ,Cohort ,Emergency medicine ,Medicine ,telemedicine ,business ,medical education ,Patient education ,Cohort study - Abstract
Background COVID-19 was declared a pandemic on March 11, 2020. Given that the severe shortage of hospital beds has led to early discharge and insufficient patient education on home care routines and isolation protocols, the close follow-up of patients and their immediate relatives is an integral part of transitioning from hospital care to home care for patients with COVID-19. Objective We designed the Tele-COVID-19 prospective cohort to follow-up with COVID-19 patients in Tehran, Iran, and improve health care delivery and the recording of postdischarge patients’ clinical profiles. Methods All adult patients who were admitted to the COVID-19 wards of teaching hospitals in Tehran, Iran were eligible to participate in this cohort study. At baseline, patients were recruited from 4 major hospitals from March 9, 2020 to May 20, 2020. Telephone follow-ups, which were led by volunteer medical students, were conducted on postdischarge days 1-3, 5, 7, 10, and 14. We collected data on a range of sociodemographic, epidemiological, and clinical characteristics by using a standard questionnaire. Results Of the 950 patients with confirmed COVID-19 who were approached, 823 (response rate: 86.6%) consented and were enrolled into the cohort. Of the 823 participants, 449 (54.5%) were male. The mean age of participants was 50.1 years (SD 12.6 years). During the initial data collection phase, more than 5000 phone calls were made and over 577 reports of critical patients who were in need of urgent medical attention were recorded. Conclusions The Tele-COVID-19 cohort will provide patients with sufficient education on home care and isolation, and medical advice on care and the proper use of drugs. In addition, by preventing unnecessary hospital returns and providing information on household SARS-CoV-2 transmission as early as possible, this cohort will help with effective disease management in resource-limited settings. International Registered Report Identifier (IRRID) DERR1-10.2196/23316
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- 2021
17. COVID-19 Among Patients With Hepatitis B or Hepatitis C: A Systematic Review
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Heidar Sharafi, Hossein Mirzaie, Mostafa Shokoohi, Mohammad Karamouzian, Hamid Sharifi, Maryam Darvishian, and Mohammad Vahidi
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Hepatitis B virus ,medicine.medical_specialty ,Hepatology ,business.industry ,Hepatitis C virus ,virus diseases ,Type 2 Diabetes Mellitus ,Context (language use) ,Hepatitis C ,Hepatitis B ,medicine.disease_cause ,medicine.disease ,Comorbidity ,digestive system diseases ,03 medical and health sciences ,Critical appraisal ,0302 clinical medicine ,Infectious Diseases ,Internal medicine ,medicine ,030211 gastroenterology & hepatology ,030212 general & internal medicine ,business - Abstract
Context: Hepatic manifestations of Coronavirus Disease 2019 (COVID-19) are common among people living with Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV). Objectives: This systematic review aimed to summarize the evidence on COVID-19 patients living with HBV or HCV co-infections. Data Sources: We searched multiple electronic databases and preprint servers from December 1, 2019, to August 9, 2020. Study Selection: Studies were included if they reported quantitative empirical data on COVID-19 patients living with HBV or HCV co-infections. Data Extraction: Descriptive analyses were reported, and data were synthesized narratively. The quality assessment was completed using the Joanna Briggs Institute critical appraisal tools. Results: Out of the 941 uniquely identified records, 27 studies were included. Of the eligible studies, 232 COVID-19 patients were living with HBV and 22 were living with HCV. Most patients were male, and the mean age was 49.8 and 62.8 years in patients living with HBV and HCV, respectively. Among the reported cases of SARS-CoV-2-HBV co-infection, the proportions of death were 4.7% and 15% in cross-sectional and case series/report studies, respectively. The death proportion was 8.3% among the reported cases of SARS-CoV-2-HCV co-infection. Among COVID-19 patients, 34.1% and 76.2% reported at least one comorbidity besides HBV and HCV infections, mainly hypertension and type 2 diabetes mellitus. The most common COVID-19-related symptoms in both HBV and HCV groups were fever, cough, dyspnea, fatigue, and gastrointestinal symptoms. Conclusions: While understanding the pathogenesis of SARS-CoV-2 requires further investigations, the careful assessment of hepatic manifestations and chronic infections, such as HBV and HCV upon the admission of COVID-19 patients could help reduce multimorbidity among HBV or HCV patients and lead to more favorable health outcomes among them.
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- 2021
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18. COVID-19 among patients with hepatitis B or hepatitis C: A systematic review
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Mostafa Shokoohi, Mohammad Karamouzian, Mohammad Vahidi, Hossein Mirzaie, Heidar Sharafi, Maryam Darvishian, and Hamid Sharifi
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Hepatitis B virus ,medicine.medical_specialty ,business.industry ,Hepatitis C virus ,virus diseases ,Hepatitis C ,Hepatitis B ,medicine.disease_cause ,medicine.disease ,Comorbidity ,digestive system diseases ,Critical appraisal ,Diabetes mellitus ,Internal medicine ,Risk of mortality ,Medicine ,business - Abstract
Background & aimsHepatic manifestations of coronavirus disease 2019 (COVID-19) are common among people infected with hepatitis B virus (HBV) and hepatitis C virus (HCV). This systematic review aimed to summarize the evidence on COVID-19 patients with HBV or HCV co-infections.MethodsWe searched multiple electronic databases and preprint servers from December 1, 2019 to August 9, 2020. Studies were included if they reported quantitative empirical data on COVID-19 patients with HBV or HCV co-infections. Descriptive analyses were reported and data were narratively synthesized. Quality assessments was completed using the Joanna Briggs Institute critical appraisal tools.ResultsOut of the 941 identified records, 28 studies were included. Of the eligible studies, 235 patients with COVID-19 were infected with HBV and 22 patients with HCV. Most patients were male and mean age was 49.8 and 62.8 in patients with HBV and HCV, respectively. Death proportion was 6% among COVID-19-HBV and 13% among COVID-19-HCV co-infected patients. Among COVID-19 patients, 34.1% and 76.2% reported at least one comorbidity besides HBV and HCV infections, mainly hypertension and diabetes mellites type 2. The most common COVID-19-related symptoms in both HBV and HCV groups were fever, cough and dyspnea. ICU admission was reported in 14.1% and 21.4% of individuals with HBV and HCV, respectively.ConclusionsOur findings suggest a considerable risk of morbidity and mortality among COVID-19 patients with HBV and HCV. Careful assessment of hepatic manifestations upon admission of patients could help improve health outcomes among COVID-19 patients with HBV or HCV co-infections.Key PointsHepatic manifestations of COVID-19 are common among people infected with HBV and HCV.Among COVID-19 patients, 34.1% and 76.2% reported at least one comorbidity besides HBV and HCV infections.The most common COVID-19-related symptoms in both HBV and HCV groups were fever, cough and dyspnea.There is a considerable risk of mortality among COVID-19 patients with HBV and HCV.
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- 2020
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19. Clinical and Epidemiological Characteristics of Postdischarge Patients With COVID-19 in Tehran, Iran: Protocol for a Prospective Cohort Study (Tele-COVID-19 Study) (Preprint)
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Laya Jalilian Khave, Mohammad Vahidi, Dorsa Shirini, Ghazal Sanadgol, Farzad Ashrafi, Mehran Arab-Ahmadi, Alireza Fatemi, Minoosh Shabani Barzegar, Taha Hassanzadeh, Behandokht Rezaei, Alireza Zali, Davood Ommi, Shabnam Nohesara, Reza Jalili Khoshnood, Saeed Abdi, Ali Pirsalehi, Ehsan Masarat, Mostafa Shokoohi, and Mohammad Karamouzian
- Abstract
BACKGROUND COVID-19 was declared a pandemic on March 11, 2020. Given that the severe shortage of hospital beds has led to early discharge and insufficient patient education on home care routines and isolation protocols, the close follow-up of patients and their immediate relatives is an integral part of transitioning from hospital care to home care for patients with COVID-19. OBJECTIVE We designed the Tele-COVID-19 prospective cohort to follow-up with COVID-19 patients in Tehran, Iran, and improve health care delivery and the recording of postdischarge patients’ clinical profiles. METHODS All adult patients who were admitted to the COVID-19 wards of teaching hospitals in Tehran, Iran were eligible to participate in this cohort study. At baseline, patients were recruited from 4 major hospitals from March 9, 2020 to May 20, 2020. Telephone follow-ups, which were led by volunteer medical students, were conducted on postdischarge days 1-3, 5, 7, 10, and 14. We collected data on a range of sociodemographic, epidemiological, and clinical characteristics by using a standard questionnaire. RESULTS Of the 950 patients with confirmed COVID-19 who were approached, 823 (response rate: 86.6%) consented and were enrolled into the cohort. Of the 823 participants, 449 (54.5%) were male. The mean age of participants was 50.1 years (SD 12.6 years). During the initial data collection phase, more than 5000 phone calls were made and over 577 reports of critical patients who were in need of urgent medical attention were recorded. CONCLUSIONS The Tele-COVID-19 cohort will provide patients with sufficient education on home care and isolation, and medical advice on care and the proper use of drugs. In addition, by preventing unnecessary hospital returns and providing information on household SARS-CoV-2 transmission as early as possible, this cohort will help with effective disease management in resource-limited settings. INTERNATIONAL REGISTERED REPORT DERR1-10.2196/23316
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- 2020
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20. A Student-Led Medical Education Initiative in Iran: Responding to COVID-19 in a Resource-Limited Setting
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Mohammad Vahidi, Mohammad Karamouzian, Taha Hasanzadeh, Laya Jalilian Khave, and Mehran Arab-Ahmadi
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2019-20 coronavirus outbreak ,Students, Medical ,Education, Medical ,Coronavirus disease 2019 (COVID-19) ,SARS-CoV-2 ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,MEDLINE ,COVID-19 ,General Medicine ,Iran ,medicine.disease ,Education ,Pandemic ,medicine ,Educational Status ,Humans ,Medical emergency ,business ,Pandemics ,Limited resources - Published
- 2020
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21. Exploring dynamic operation of a solar dish-stirling engine: Validation and implementation of a novel TRNSYS type
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Yasser Abbassi and Mohammad Vahidi Bidhendi
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geography ,Stirling engine ,geography.geographical_feature_category ,Renewable Energy, Sustainability and the Environment ,020209 energy ,Electric potential energy ,Energy Engineering and Power Technology ,Flux ,02 engineering and technology ,TRNSYS ,Automotive engineering ,Sink (geography) ,law.invention ,Power (physics) ,Fossil fuel consumption ,Electricity generation ,020401 chemical engineering ,law ,0202 electrical engineering, electronic engineering, information engineering ,Environmental science ,0204 chemical engineering - Abstract
The combination of solar dishes and Stirling engines is a promising and reliable technology to convert solar radiation into power which can minimize fossil fuel consumption for electricity generation. The current research intends to explore solar dish/Stirling engine system functionality under different operating conditions and climates. A numerical routine has been developed and adopted to TRNSYS© to estimate the impact of dynamic parameters, including irradiation flux and ambient temperature on the daily, monthly, or seasonal performance and efficiency of the solar dish-Stirling engine system. The routine is based on Schmidt’s theory in association with a heat transfer model for the receiver of the dish. First, the routine has been validated against experimental measurements with an error below 15%. Then, the effect of the dish’s angle and cold sink temperature on system efficiency have been investigated. It is found that an approximately 5% increase in power will be realistic if the cold sink temperature fell by 30 degrees. Eventually, the annual performance of the system in different climates has been examined. It can be concluded that the best output of the system will occur in desert climates with over 20 GJ of electrical energy per year (24% efficiency). In contrast, in a continental humid climate, the rate of power generation is 50% lower (15% efficiency).
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- 2020
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22. Additional file 6: of Recessive mutations in ATP8A2 cause severe hypotonia, cognitive impairment, hyperkinetic movement disorders and progressive optic atrophy
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McMillan, Hugh, Telegrafi, Aida, Singleton, Amanda, Cho, Megan, Lelli, Daniel, Lynn, Francis, Griffin, Julie, Asamoah, Alexander, Rinne, Tuula, Erasmus, Corrie, Koolen, David, Haaxma, Charlotte, Keren, Boris, Doummar, Diane, Mignot, Cyril, Islay Thompson, Velsher, Lea, Mohammadreza Dehghani, Mehrjardi, Mohammad Vahidi, Maroofian, Reza, Tchan, Michel, Simons, Cas, Christodoulou, John, MartĂN-HernĂĄndez, Elena, Sacoto, Maria Guillen, Henderson, Lindsay, McLaughlin, Heather, Molday, Laurie, Molday, Robert, and Yoon, Grace
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embryonic structures - Abstract
Supplementary Data - additional clinical histories. Figure S1. Expression of FOXA2 and SOX17 in differentiated cells from Patient 1 compared to control cells. (PDF 28 kb)
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- 2018
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23. Methamphetamine-Associated Psychosis and Treatment With Haloperidol and Risperidone: A Pilot Study
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Mercede Samiei, Reza Daneshmand, Azadeh Yaraghchi, Mohammad Vahidi, and Omid Rezaee
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medicine.medical_specialty ,Psychosis ,law.invention ,Methamphetamine ,03 medical and health sciences ,Behavioral Neuroscience ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Haloperidol ,Psychiatric hospital ,030212 general & internal medicine ,Psychiatry ,Biological Psychiatry ,Risperidone ,business.industry ,medicine.disease ,030227 psychiatry ,Treatment ,Psychiatry and Mental health ,Antipsychotic Medications ,Original Article ,business ,After treatment ,medicine.drug - Abstract
Background: Different studies have suggested that antipsychotic medications of the first generation have better effectiveness for the treatment of psychotic symptoms compared with antipsychotic medications of the second generation. Objectives: The current study was the first pilot study in Iran that compared Haloperidol with Risperidone in the treatment of positive symptoms of psychosis among a group of methamphetamine-dependent patients. Materials and Methods: This randomized clinical trial was designed and conducted in 2012. Overall, 44 patients who met the diagnostic and statistical manual of mental disorders, fourth edition-text revised (DSM.IV-TR) criteria for methamphetamine-associated psychosis (MAP) and were hospitalized at Razi psychiatric hospital in Tehran were selected. Patients (1: 1) were randomly divided to two groups. Overall, 22 subjects received Haloperidol (5 - 20 mg) and 22 subjects received Risperidone (2 - 8 mg). All subjects were assessed at baseline, during three consecutive weeks of treatment and one week after treatment (i.e., follow-up). Scale of assessment of positive symptoms (SAPS) was completed for each subject. Results: The study findings indicated that both Haloperidol (< 0.05) and Risperidone (< 0.05) were similarly applicable in the treatment of MAP but no differential effectiveness was found between the two medications. The treatment effects of both medications increased in the first two weeks of treatment and remained stable in the second two weeks. Conclusions: Risperidone and Haloperidol are two effective antipsychotic medications for the treatment of positive symptoms of MAP but other aspects of these two neuroleptic medications such as the long-term treatment effects should be studied. Further studies with more samples and longer follow-ups are suggested.
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- 2016
24. Study of main planktonic foraminifera(Turonian-Santonian) in Kopeh-Dagh sedimentary environment, NE Iran
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Meysam Shafiee Ardestani and Mohammad Vahidinia
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abderaz formation ,biostratigraphy ,biozone ,planktonic foraminifera ,sub hersinian orogeny ,Environmental sciences ,GE1-350 - Abstract
In order to study the fossil contents of the Abderaz Formation for biostratigraphical purposes the 500 meters thick section was sampled at type section. The sequence is mainly made up of grey shales and marls with two units of chalky limestone in upper part. The lower contact of the formation with Aitamir Formation is disconform while the upper contact with Abtalkh is continuous. Fifty six species belonging to 16 genera were identified and four biozones were differentiated. These are: Helvetoglobotruncana helvetica (Sigal)total range Zone, 2-Marginotruncana sigali - Dicarinella primitiva (Premoli Silva and Sliter)Partial range Zone, 3- Dicarinella concavata (Sigal)interval Zone and4-Dicarinella asymetrica (Postuma)total range Zone. Based on, these an age of Turonian-Late Santonian is quoted to the formation. Also it was shown that Helvetoglobotruncana helvetica, the index species for middle Turonian exists at the base of the formation while, in the samples immediately below this belonging to Aitamir Formation Rotalipora appenninica, the index for middel cenomanian was recorded. Therefore, lack of index species for late Cenomanian- early Turonian shows a gap spanning this period between the Aitamir and Abderaz formations. This could be a result of sub Hersinian orogeny.
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- 2021
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25. Biostratigraphy of the Pabdeh Formation in the Parsi Oil Field (Dezful Embayment, South-West Iran)
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Masume Sabokro, Mohammad Vahidinia, Mohammed Hussain Adabi, and Nasrin Hadavandkhani
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pabdeh formation ,paleocene ,oligocene ,dezful embayment ,parsi oil field ,Stratigraphy ,QE640-699 - Abstract
AbstractIn order to study biostratigraphy and the determination of biozonation in the Pabdeh Formation based on the new planktonic foraminifera biozonation in the Tethys region, one subsurface section in well 1 of the Parsi Oil Field was selected in the southern Dezful Embayment. Based on this study, a biostratigraphic study of 320 thin sections from well 1 of Parsi Oil Field has been carried out. The Pabdeh Formation with a thickness of 404 m consists mainly of shales, marls, argillaceous limestones, and cherty limestone. The lower boundary of the Pabdeh Formation with the Gurpi Formation is unconformable and the upper boundary with the Asmari Formation is conformable. Biostratigraphic studies led to the recognition of 25 genera and 75 species of planktonic foraminifera and then 19 biozones equivalent to the new biozone of Wade et al. (2011) in the Tethys region. These identified biozones include three biozones in the Paleocene, 11 biozones in the Eocene and five biozones in the Oligocene in the studied section in well 1 of Parsi Oil Field and are well correlated with some biozones in the Tethys region. Based on the identified biozones and fossil contents, the age of the Pabdeh Formation is Middle Paleocene (Selandian)–Late Oligocene (Chattian). Keywords: Pabdeh Formation; Paleocene; Oligocene; Dezful Embayment; Parsi Oil Field IntroductionThe Pabdeh Formation as a hydrocarbon source rock is widespread in the Zagros Basin. The type section of the Pabdeh Formation is located in Tange Pabdeh (North of Lali Oil Field) with a thickness of about 800 meters of shales and purple marls, grey shales, layers of argillaceous limestone and sometimes cherty limestones. It contains well-preserved foraminifera that gradually reaches the limestone of the Asmari Formation and spreads in the southwest of Lorestan, Khuzestan, and Fars provinces (Motiei 1995).Most of the biostratigraphic studies of the Pabdeh Formation in the Dezful Embayment are based on biozones (James and Wynd 1965) which are local and have not the capability to correlate with the global biozones. The purpose of this paper is to study the biostratigraphy of the Pabdeh Formation based on foraminifera and biozones based on standard biozones in the Tethys region (Wade et al. 2011) in the Parsi Oil Field (well No. 1). Material & MethodsIn order to identify the biozones of the Pabdeh Formation based on planktonic foraminifera and the new biozonation in the Tethys region, 320 thin sections microscopy of the subsurface section in well No. 1 of the Parsi Oil Field has been studied. Identification of genus and species, the age range of planktonic foraminifera and biozone of the Pabdeh Formation has been studied based on the following literatures (Postuma 1971; Olsson et al. 1999; Premoli Silva et al. 2003; Iaccarino et al. 2005; Berggren and Pearson 2005; Berggren and Pearson 2006; Pearson et al. 2006; Wade et al. 2011; 2018; BouDagher 2015; Berggren et al. 2018). Discussion of Results & ConclusionsPlanktonic foraminifera is widely utilized for the biostratigraphy of Cretaceous and Cenozoic marine sediments and is a fundamental component of Cenozoic chronostratigraphic biozonation (Wade et al. 2011). In this study, biostratigraphy of the Pabdeh Formation in the studied section led to the recognition of 75 species belonging to 25 genus of planktonic foraminifera and 19 biozones based and/or equivalent new biozonation (Wade et al. 2011) were identified and determined. These identified biozones, (P4) belonging to Paleocene and (E2-E5-E7-E8-E9-E10-E11) to Eocene in the studied section, are well correlated with biozones of Tethys region and other identified biozones:The equivalent of Zone P3. Globanomalina pseudomenardii Lowest-occurrence Zone Zone P4. Globanomalina pseudomenardii Taxon- range ZoneEquivalent of Zones (P5&E1). Globanomalina pseudomenardii/Pseudohastigerina wilcoxensis Interval ZoneZone E2. Pseudohastigerina wilcoxensis/Morozovella velascoensis Concurrent-range ZoneEquivalent of Zones (E3 & E4). Acarinina pseudotopilensis Partial-range ZoneZone E5. Morozovella aragonensis/Morozovella subbotinae Concurrent- range ZoneThe equivalent of Zone E6. Morozovella subbotinae /Acarinina cuneicamerata Interval ZoneZone E7. Acarinina cuneicamerata Lowest- occurrence ZoneZone E8. Guembelitrioides nuttalli Lowest-occurrence ZoneZone E9. Globigerinatheka kugleri/ Morozovella aragonensis Concurrent- range ZoneZone E10. Acarinina topilensis Partial-range ZoneZone E11. Morozovelloides lehneri Partial-range ZoneThe equivalent of Zones (E12 & E13). Orbulinoides beckmanni /Morozovelloides crassatus Interval ZoneThe equivalent of Zones (E14 - E15- E16). Hantkenina Highest-occurrence ZoneThe equivalent of Zone O1. Pseudohastigerina Highest-occurrence Zone The equivalent of Zone O2. Turborotalia ampliapertura Highest-occurrence ZoneThe equivalent of Zone O3. Turborotalia ampliapertura /Ciperoella angulisuturalis Interval ZoneThe equivalent of Zone O4. Ciperoella angulisuturalis /Chiloguembelina Interval ZoneThe equivalent of Zones (O5-O6-O7). Trilobatus primordius / Pragloborotalia / Ciperoella assemblage ZoneBased on this study, the lower boundary of the Pabdeh Formation with the Gurpi Formation is unconformable. Studies by Jalali (1971) indicated that there was no sedimentation at the base of the Paleocene and at the end of the Cretaceous. A lack of stratigraphy is evident during the Late Maastrichtian, Early Paleocene (Danin), and earlyMiddle Paleocene. Defined biozones are compared with the other sections presented in the Izeh Zone (Tange Hatti, north flank of Tange Pabdeh and Chahardeh) in the Zagros Basin (SW Iran).Based on biostratigraphic studies of the Pabdeh Formation by Hadavandkhani (2015), in Tange Hatti, north flank of Tange Pabdeh and Chahardeh in the Izeh Zone and studies on Parsi Oil Field (well No. 1) in the Dezful Embayment show that standard biozonation of Tethys region, specially biozonation (Wade et al. 2011) can be considered as a model zonation in the Zagros Basin for the Pabdeh Formation
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- 2021
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26. Microfacies analysis of Eocene Ziarat Formation (eastern Alborz zone, NE Iran) and paleoenvironmental implications
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Mehdi Hadi, Suman Sarkar, Mohammad Vahidinia, and Aram Bayet-Goll
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paleoenvironment ,eocene ,larger benthic foraminifera ,microfacies ,ziarat formation ,Geology ,QE1-996.5 ,Physical geography ,GB3-5030 - Abstract
Despite belonging to an important time slice in the geological history, the Eocene shallow-marine beds of the Alborz region in Iran have received little attention from researchers. We selected two stratigraphic sections (Mojen and Kalateh) ascribed to the Ziarat Formation as suitable representatives for the current analysis, emphasising on their constituent microfacies and paleoenvironmental implications. The biotic communities are characterised by larger benthic foraminifera (LBF), coralline algae, corals, and bivalves as the major carbonate facies components. The microfacies gradients and paleoenvironmental analysis suggest deposition in a shallow-marine oligotrophic ramp environment within two platform stages. Both these stages indicate an increase in water depth from the inner to the middle ramp settings with spatial distribution of the LBF and other benthic components. Our data support the previous view that the early Eocene witnessed an increase in LBF taxa with near obliteration of the coral reefs in the sedimentary platforms across the Tethys. The corals reinitiated building reefal structures in the Middle Eocene, marking an important phase in the Tethyan paleoenvironmental evolution.
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- 2021
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27. Neutrophil-to-lymphocyte ratio (NLR) greater than 6.5 May reflect the progression of COVID-19 towards an unfavorable clinical outcome
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Mohammad Esmaeil Akbari, Ali Pirsalehi, Davood Bashash, Mohammad Vahidi, Sina Salari, Laya Jalilian Khave, and Ahmad Reza Baghestani
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Microbiology (medical) ,medicine.medical_specialty ,SARS-CoV-2 ,lcsh:QR1-502 ,Disease ,01 natural sciences ,Microbiology ,lcsh:Microbiology ,law.invention ,law ,Internal medicine ,Intensive care ,0502 economics and business ,medicine ,Hematological parameters ,0101 mathematics ,Neutrophil to lymphocyte ratio ,Neutrophil-to-lymphocyte ratio ,business.industry ,010102 general mathematics ,05 social sciences ,Outbreak ,COVID-19 ,Retrospective cohort study ,medicine.disease ,Prognosis ,Intensive care unit ,Neutrophilia ,Pneumonia ,Original Article ,medicine.symptom ,business ,050203 business & management - Abstract
Background and Objectives: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was first described during a pneumonia outbreak in Wuhan, has attracted tremendous attention in a short period of time as the death toll and the number of confirmed cases is growing unceasingly. Although molecular testing is the gold standard method of SARS-CoV-2 detection, the existence of the false-negative results presents a major limitation to this method. Materials and Methods: This retrospective Double-Centre study was conducted on 1320 COVID-19 patients recruited at Taleghani and Shohadae Tajrish Hospitals in Tehran, Iran. We analyzed the leukocyte, lymphocyte and neutrophil counts of hospitalized cases both on admission and at discharge. We also evaluated the alteration of these parameters within a seven-day follow-up. Results: Of the whole, 1077 (81.6%) neither were admitted to intensive care unit (ICU) nor experienced death, and were defined as the mild-moderate group. Of 243 severe cases, while 59 (24.3%) were admitted to ICU and cured with the intensive care services, 184 (75.7%) patients died of the disease, either with or without ICU admission. Calculation of neutrophil-to-lymphocyte ratio (NLR) revealed that the mild-moderate cases had a lower ratio at discharge. On the other hand, the ratio was significantly higher in the death group as compared to the ICU group; highlighting the fact that patients with a higher degree of neutrophilia and a greater level of lymphopenia have a poor prognosis. Conclusion: We suggest that NLR greater than 6.5 may reflect the progression of the disease towards an unfavorable clinical outcome, with this notion that the ratios higher than 9 may strongly result in death.
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