1. The beneficial effects of crocin supplementation on metabolic and genetic parameters in type 2 diabetic patients under metformin treatment: A randomized double-blind controlled clinical trial
- Author
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Alireza Mafi, Bijan Iraj, and Mohammad Hossein Aarabi
- Subjects
Crocin ,Supplementation ,Type-2 Diabetes Mellitus ,Metformin ,Antioxidant ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Background and objective: Since it has been demonstrated that inflammation and oxidative stress (OS) are important in the etiology and complexity of type 2 diabetes mellitus (T2DM), antioxidant treatment is recognized as an effective approach for managing the progression of the disease. The current study was conducted to assess the effects of crocin administration on metabolic and genetic indices in T2DM patients who were receiving metformin. Materials and methods: Sixty T2DM patients, receiving metformin, were included in our randomized double-blind placebo-controlled clinical trial. Patients were divided into two groups (n = 30) and received either 15 mg/day crocin supplementation or a placebo twice a day for 12 weeks. Fasting blood was obtained at the beginning and end of the intervention to assess glycemic index, lipid content, indicators of inflammation, and OS. Patients’ peripheral blood mononuclear cells (PBMC) were analyzed for gene expression associated with OS and inflammation using real-time polymerase chain reaction (real-time PCR). Results: Crocin intake significantly decreased fasting plasma glucose (P < 0.001), HbA1c (P = 0.002), serum insulin levels (P = 0.03), and insulin resistance (P < 0.001), while significantly enhanced insulin sensitivity (P
- Published
- 2024
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